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 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:RPTOR-IQCH (FusionGDB2 ID:78229) |
Fusion Gene Summary for RPTOR-IQCH |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: RPTOR-IQCH | Fusion gene ID: 78229 | Hgene | Tgene | Gene symbol | RPTOR | IQCH | Gene ID | 57521 | 128153 |
| Gene name | regulatory associated protein of MTOR complex 1 | spermatogenesis associated 17 | |
| Synonyms | KOG1|Mip1 | CFAP305|FAP305|IQCH|MOT17|MSRG-11|MSRG11 | |
| Cytomap | 17q25.3 | 1q41 | |
| Type of gene | protein-coding | protein-coding | |
| Description | regulatory-associated protein of mTORp150 target of rapamycin (TOR)-scaffold protein containing WD-repeatsraptor | spermatogenesis-associated protein 17IQ motif containing Hspermatogenesis-related protein 11 | |
| Modification date | 20200313 | 20200313 | |
| UniProtAcc | . | Q86VS3 | |
| Ensembl transtripts involved in fusion gene | ENST00000575542, ENST00000306801, ENST00000537330, ENST00000544334, ENST00000570891, | ENST00000335894, ENST00000358767, ENST00000360277, ENST00000546225, ENST00000512104, ENST00000560790, | |
| Fusion gene scores | * DoF score | 26 X 20 X 11=5720 | 8 X 11 X 6=528 |
| # samples | 27 | 12 | |
| ** MAII score | log2(27/5720*10)=-4.40498383461492 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(12/528*10)=-2.13750352374993 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: RPTOR [Title/Abstract] AND IQCH [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | RPTOR(78829347)-IQCH(67692452), # samples:3 | ||
| Anticipated loss of major functional domain due to fusion event. | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | RPTOR | GO:0031929 | TOR signaling | 20381137 |
| Hgene | RPTOR | GO:0032008 | positive regulation of TOR signaling | 12150926|18439900 |
| Hgene | RPTOR | GO:0071233 | cellular response to leucine | 22424946 |
| Hgene | RPTOR | GO:0071902 | positive regulation of protein serine/threonine kinase activity | 12150926 |
| Fusion gene breakpoints across RPTOR (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene breakpoints across IQCH (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | PRAD | TCGA-KK-A8ID-01A | RPTOR | chr17 | 78829347 | - | IQCH | chr15 | 67692452 | + |
| ChimerDB4 | PRAD | TCGA-KK-A8ID-01A | RPTOR | chr17 | 78829347 | + | IQCH | chr15 | 67692452 | + |
| ChimerDB4 | PRAD | TCGA-KK-A8ID | RPTOR | chr17 | 78829347 | + | IQCH | chr15 | 67692452 | + |
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Fusion Gene ORF analysis for RPTOR-IQCH |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 3UTR-3CDS | ENST00000575542 | ENST00000335894 | RPTOR | chr17 | 78829347 | + | IQCH | chr15 | 67692452 | + |
| 3UTR-3CDS | ENST00000575542 | ENST00000358767 | RPTOR | chr17 | 78829347 | + | IQCH | chr15 | 67692452 | + |
| 3UTR-3CDS | ENST00000575542 | ENST00000360277 | RPTOR | chr17 | 78829347 | + | IQCH | chr15 | 67692452 | + |
| 3UTR-3CDS | ENST00000575542 | ENST00000546225 | RPTOR | chr17 | 78829347 | + | IQCH | chr15 | 67692452 | + |
| 3UTR-intron | ENST00000575542 | ENST00000512104 | RPTOR | chr17 | 78829347 | + | IQCH | chr15 | 67692452 | + |
| 3UTR-intron | ENST00000575542 | ENST00000560790 | RPTOR | chr17 | 78829347 | + | IQCH | chr15 | 67692452 | + |
| 5CDS-intron | ENST00000306801 | ENST00000512104 | RPTOR | chr17 | 78829347 | + | IQCH | chr15 | 67692452 | + |
| 5CDS-intron | ENST00000306801 | ENST00000560790 | RPTOR | chr17 | 78829347 | + | IQCH | chr15 | 67692452 | + |
| 5CDS-intron | ENST00000537330 | ENST00000512104 | RPTOR | chr17 | 78829347 | + | IQCH | chr15 | 67692452 | + |
| 5CDS-intron | ENST00000537330 | ENST00000560790 | RPTOR | chr17 | 78829347 | + | IQCH | chr15 | 67692452 | + |
| 5CDS-intron | ENST00000544334 | ENST00000512104 | RPTOR | chr17 | 78829347 | + | IQCH | chr15 | 67692452 | + |
| 5CDS-intron | ENST00000544334 | ENST00000560790 | RPTOR | chr17 | 78829347 | + | IQCH | chr15 | 67692452 | + |
| In-frame | ENST00000306801 | ENST00000335894 | RPTOR | chr17 | 78829347 | + | IQCH | chr15 | 67692452 | + |
| In-frame | ENST00000306801 | ENST00000358767 | RPTOR | chr17 | 78829347 | + | IQCH | chr15 | 67692452 | + |
| In-frame | ENST00000306801 | ENST00000360277 | RPTOR | chr17 | 78829347 | + | IQCH | chr15 | 67692452 | + |
| In-frame | ENST00000306801 | ENST00000546225 | RPTOR | chr17 | 78829347 | + | IQCH | chr15 | 67692452 | + |
| In-frame | ENST00000537330 | ENST00000335894 | RPTOR | chr17 | 78829347 | + | IQCH | chr15 | 67692452 | + |
| In-frame | ENST00000537330 | ENST00000358767 | RPTOR | chr17 | 78829347 | + | IQCH | chr15 | 67692452 | + |
| In-frame | ENST00000537330 | ENST00000360277 | RPTOR | chr17 | 78829347 | + | IQCH | chr15 | 67692452 | + |
| In-frame | ENST00000537330 | ENST00000546225 | RPTOR | chr17 | 78829347 | + | IQCH | chr15 | 67692452 | + |
| In-frame | ENST00000544334 | ENST00000335894 | RPTOR | chr17 | 78829347 | + | IQCH | chr15 | 67692452 | + |
| In-frame | ENST00000544334 | ENST00000358767 | RPTOR | chr17 | 78829347 | + | IQCH | chr15 | 67692452 | + |
| In-frame | ENST00000544334 | ENST00000360277 | RPTOR | chr17 | 78829347 | + | IQCH | chr15 | 67692452 | + |
| In-frame | ENST00000544334 | ENST00000546225 | RPTOR | chr17 | 78829347 | + | IQCH | chr15 | 67692452 | + |
| intron-3CDS | ENST00000570891 | ENST00000335894 | RPTOR | chr17 | 78829347 | + | IQCH | chr15 | 67692452 | + |
| intron-3CDS | ENST00000570891 | ENST00000358767 | RPTOR | chr17 | 78829347 | + | IQCH | chr15 | 67692452 | + |
| intron-3CDS | ENST00000570891 | ENST00000360277 | RPTOR | chr17 | 78829347 | + | IQCH | chr15 | 67692452 | + |
| intron-3CDS | ENST00000570891 | ENST00000546225 | RPTOR | chr17 | 78829347 | + | IQCH | chr15 | 67692452 | + |
| intron-intron | ENST00000570891 | ENST00000512104 | RPTOR | chr17 | 78829347 | + | IQCH | chr15 | 67692452 | + |
| intron-intron | ENST00000570891 | ENST00000560790 | RPTOR | chr17 | 78829347 | + | IQCH | chr15 | 67692452 | + |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000537330 | RPTOR | chr17 | 78829347 | + | ENST00000358767 | IQCH | chr15 | 67692452 | + | 4300 | 2126 | 1256 | 3103 | 615 |
| ENST00000537330 | RPTOR | chr17 | 78829347 | + | ENST00000546225 | IQCH | chr15 | 67692452 | + | 4362 | 2126 | 1256 | 3304 | 682 |
| ENST00000537330 | RPTOR | chr17 | 78829347 | + | ENST00000335894 | IQCH | chr15 | 67692452 | + | 4363 | 2126 | 1256 | 3304 | 682 |
| ENST00000537330 | RPTOR | chr17 | 78829347 | + | ENST00000360277 | IQCH | chr15 | 67692452 | + | 4300 | 2126 | 1256 | 3103 | 615 |
| ENST00000306801 | RPTOR | chr17 | 78829347 | + | ENST00000358767 | IQCH | chr15 | 67692452 | + | 3934 | 1760 | 308 | 2737 | 809 |
| ENST00000306801 | RPTOR | chr17 | 78829347 | + | ENST00000546225 | IQCH | chr15 | 67692452 | + | 3996 | 1760 | 308 | 2938 | 876 |
| ENST00000306801 | RPTOR | chr17 | 78829347 | + | ENST00000335894 | IQCH | chr15 | 67692452 | + | 3997 | 1760 | 308 | 2938 | 876 |
| ENST00000306801 | RPTOR | chr17 | 78829347 | + | ENST00000360277 | IQCH | chr15 | 67692452 | + | 3934 | 1760 | 308 | 2737 | 809 |
| ENST00000544334 | RPTOR | chr17 | 78829347 | + | ENST00000358767 | IQCH | chr15 | 67692452 | + | 3734 | 1560 | 108 | 2537 | 809 |
| ENST00000544334 | RPTOR | chr17 | 78829347 | + | ENST00000546225 | IQCH | chr15 | 67692452 | + | 3796 | 1560 | 108 | 2738 | 876 |
| ENST00000544334 | RPTOR | chr17 | 78829347 | + | ENST00000335894 | IQCH | chr15 | 67692452 | + | 3797 | 1560 | 108 | 2738 | 876 |
| ENST00000544334 | RPTOR | chr17 | 78829347 | + | ENST00000360277 | IQCH | chr15 | 67692452 | + | 3734 | 1560 | 108 | 2537 | 809 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000537330 | ENST00000358767 | RPTOR | chr17 | 78829347 | + | IQCH | chr15 | 67692452 | + | 0.008390731 | 0.9916093 |
| ENST00000537330 | ENST00000546225 | RPTOR | chr17 | 78829347 | + | IQCH | chr15 | 67692452 | + | 0.005240748 | 0.99475926 |
| ENST00000537330 | ENST00000335894 | RPTOR | chr17 | 78829347 | + | IQCH | chr15 | 67692452 | + | 0.005242394 | 0.99475765 |
| ENST00000537330 | ENST00000360277 | RPTOR | chr17 | 78829347 | + | IQCH | chr15 | 67692452 | + | 0.008390731 | 0.9916093 |
| ENST00000306801 | ENST00000358767 | RPTOR | chr17 | 78829347 | + | IQCH | chr15 | 67692452 | + | 0.00207625 | 0.99792373 |
| ENST00000306801 | ENST00000546225 | RPTOR | chr17 | 78829347 | + | IQCH | chr15 | 67692452 | + | 0.001280699 | 0.99871933 |
| ENST00000306801 | ENST00000335894 | RPTOR | chr17 | 78829347 | + | IQCH | chr15 | 67692452 | + | 0.00128085 | 0.9987192 |
| ENST00000306801 | ENST00000360277 | RPTOR | chr17 | 78829347 | + | IQCH | chr15 | 67692452 | + | 0.00207625 | 0.99792373 |
| ENST00000544334 | ENST00000358767 | RPTOR | chr17 | 78829347 | + | IQCH | chr15 | 67692452 | + | 0.002073121 | 0.99792683 |
| ENST00000544334 | ENST00000546225 | RPTOR | chr17 | 78829347 | + | IQCH | chr15 | 67692452 | + | 0.001254756 | 0.9987452 |
| ENST00000544334 | ENST00000335894 | RPTOR | chr17 | 78829347 | + | IQCH | chr15 | 67692452 | + | 0.001255313 | 0.9987446 |
| ENST00000544334 | ENST00000360277 | RPTOR | chr17 | 78829347 | + | IQCH | chr15 | 67692452 | + | 0.002073121 | 0.99792683 |
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Fusion Genomic Features for RPTOR-IQCH |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| RPTOR | chr17 | 78829347 | + | IQCH | chr15 | 67692451 | + | 0.003710507 | 0.9962895 |
| RPTOR | chr17 | 78829347 | + | IQCH | chr15 | 67692451 | + | 0.003710507 | 0.9962895 |
| RPTOR | chr17 | 78829347 | + | IQCH | chr15 | 67692451 | + | 0.003710507 | 0.9962895 |
| RPTOR | chr17 | 78829347 | + | IQCH | chr15 | 67692451 | + | 0.003710507 | 0.9962895 |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
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| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for RPTOR-IQCH |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:78829347/chr15:67692452) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| . | IQCH |
| FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. | FUNCTION: May play a regulatory role in spermatogenesis. {ECO:0000269|PubMed:15897968}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | IQCH | chr17:78829347 | chr15:67692452 | ENST00000360277 | 4 | 12 | 369_398 | 296 | 1009.3333333333334 | Domain | IQ | |
| Tgene | IQCH | chr17:78829347 | chr15:67692452 | ENST00000512104 | 0 | 6 | 369_398 | 0 | 169.0 | Domain | IQ | |
| Tgene | IQCH | chr17:78829347 | chr15:67692452 | ENST00000546225 | 11 | 20 | 369_398 | 292 | 685.0 | Domain | IQ |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | RPTOR | chr17:78829347 | chr15:67692452 | ENST00000306801 | + | 12 | 34 | 881_887 | 466 | 1336.0 | Compositional bias | Note=Poly-Ser |
| Hgene | RPTOR | chr17:78829347 | chr15:67692452 | ENST00000570891 | + | 1 | 9 | 881_887 | 0 | 380.0 | Compositional bias | Note=Poly-Ser |
| Hgene | RPTOR | chr17:78829347 | chr15:67692452 | ENST00000306801 | + | 12 | 34 | 1020_1061 | 466 | 1336.0 | Repeat | Note=WD 1 |
| Hgene | RPTOR | chr17:78829347 | chr15:67692452 | ENST00000306801 | + | 12 | 34 | 1065_1106 | 466 | 1336.0 | Repeat | Note=WD 2 |
| Hgene | RPTOR | chr17:78829347 | chr15:67692452 | ENST00000306801 | + | 12 | 34 | 1121_1160 | 466 | 1336.0 | Repeat | Note=WD 3 |
| Hgene | RPTOR | chr17:78829347 | chr15:67692452 | ENST00000306801 | + | 12 | 34 | 1164_1203 | 466 | 1336.0 | Repeat | Note=WD 4 |
| Hgene | RPTOR | chr17:78829347 | chr15:67692452 | ENST00000306801 | + | 12 | 34 | 1209_1249 | 466 | 1336.0 | Repeat | Note=WD 5 |
| Hgene | RPTOR | chr17:78829347 | chr15:67692452 | ENST00000306801 | + | 12 | 34 | 1251_1291 | 466 | 1336.0 | Repeat | Note=WD 6 |
| Hgene | RPTOR | chr17:78829347 | chr15:67692452 | ENST00000306801 | + | 12 | 34 | 1299_1335 | 466 | 1336.0 | Repeat | Note=WD 7 |
| Hgene | RPTOR | chr17:78829347 | chr15:67692452 | ENST00000570891 | + | 1 | 9 | 1020_1061 | 0 | 380.0 | Repeat | Note=WD 1 |
| Hgene | RPTOR | chr17:78829347 | chr15:67692452 | ENST00000570891 | + | 1 | 9 | 1065_1106 | 0 | 380.0 | Repeat | Note=WD 2 |
| Hgene | RPTOR | chr17:78829347 | chr15:67692452 | ENST00000570891 | + | 1 | 9 | 1121_1160 | 0 | 380.0 | Repeat | Note=WD 3 |
| Hgene | RPTOR | chr17:78829347 | chr15:67692452 | ENST00000570891 | + | 1 | 9 | 1164_1203 | 0 | 380.0 | Repeat | Note=WD 4 |
| Hgene | RPTOR | chr17:78829347 | chr15:67692452 | ENST00000570891 | + | 1 | 9 | 1209_1249 | 0 | 380.0 | Repeat | Note=WD 5 |
| Hgene | RPTOR | chr17:78829347 | chr15:67692452 | ENST00000570891 | + | 1 | 9 | 1251_1291 | 0 | 380.0 | Repeat | Note=WD 6 |
| Hgene | RPTOR | chr17:78829347 | chr15:67692452 | ENST00000570891 | + | 1 | 9 | 1299_1335 | 0 | 380.0 | Repeat | Note=WD 7 |
| Tgene | IQCH | chr17:78829347 | chr15:67692452 | ENST00000335894 | 12 | 21 | 369_398 | 635 | 1028.0 | Domain | IQ |
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Fusion Gene Sequence for RPTOR-IQCH |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >78229_78229_1_RPTOR-IQCH_RPTOR_chr17_78829347_ENST00000306801_IQCH_chr15_67692452_ENST00000335894_length(transcript)=3997nt_BP=1760nt GAGAGCAGGGTCATCGTGAGGCCTGAAGTCTCTTACGCTTTTGGCAGCTCCCCTCGCAGCCCCTCTGGAAACGTACAGCCTCAGGAGCAG CCAGTGGCTTGGGACCTGGGGTGGTGTGTGTCTGCGGAGCTTCTTGGGCTGCCCCATTTCCTAGCGGCCCCCACCTCCCCACTTCCCGCT CAGAGTTAGAGATAAGGATCTCAGACTTTTGCCTGAGTAAGGGTCTCCGCACTCTTTATCCATTTGGTTTTCGATTTCCCGTTTTTGTTT CTTATTTCACCAATTCTGGTACACGCTAGTTTTTAAGGCTGGAGGTTCTCGAGCGCTTGCTGCCAAGGACTCCCCCACCCCCTCCCCCAC TGATGGAGTCCGAAATGCTGCAATCGCCTCTTCTGGGCCTGGGGGAGGAAGATGAGGCTGATCTTACAGACTGGAACCTACCTTTGGCTT TTATGAAAAAGAGGCACTGTGAGAAAATTGAAGGCTCCAAATCCTTAGCTCAGAGCTGGAGGATGAAGGATCGGATGAAGACAGTCAGTG TTGCCTTAGTTTTGTGCCTGAATGTTGGTGTGGACCCTCCCGATGTGGTGAAGACCACGCCCTGTGCACGCTTGGAATGCTGGATCGATC CTCTGTCGATGGGTCCTCAGAAAGCTCTGGAAACCATCGGTGCAAATTTACAGAAGCAGTACGAGAACTGGCAGCCAAGGGCCCGGTACA AGCAGAGCCTTGACCCAACTGTGGATGAAGTCAAGAAGCTCTGCACGTCCTTACGTCGCAACGCCAAGGAGGAGCGAGTCCTCTTTCACT ACAATGGCCACGGGGTGCCCCGGCCCACAGTCAACGGGGAGGTCTGGGTCTTCAACAAGAACTACACGCAGTACATCCCTCTGTCCATAT ATGACCTGCAGACGTGGATGGGCAGCCCGTCGATCTTCGTCTACGACTGCTCCAATGCTGGCTTGATCGTCAAGTCCTTCAAGCAGTTCG CACTACAGCGGGAGCAGGAGCTGGAGGTAGCTGCAATCAACCCAAATCACCCTCTTGCTCAGATGCCTTTGCCTCCGTCGATGAAAAACT GCATCCAGCTGGCAGCCTGCGAGGCCACCGAGCTGCTGCCCATGATCCCCGACCTCCCGGCTGACCTATTCACCTCCTGCCTCACCACCC CCATCAAGATCGCCCTGCGCTGGTTTTGCATGCAGAAATGTGTCAGTCTGGTGCCTGGCGTCACACTGGATTTGATAGAAAAGATCCCTG GCCGCCTGAACGACAGGAGGACGCCCCTGGGTGAACTGAACTGGATCTTCACAGCCATCACAGACACCATCGCGTGGAACGTGCTCCCCC GGGATCTCTTCCAAAAGCTCTTCAGACAGGACTTGCTGGTGGCTAGTCTGTTTCGAAATTTTTTATTGGCGGAAAGGATTATGAGGTCGT ATAACTGCACTCCCGTCAGCAGCCCGCGTCTGCCGCCCACGTACATGCACGCCATGTGGCAAGCCTGGGACCTGGCTGTTGACATCTGTC TGTCTCAGCTGCCGACGATCATCGAGGAAGGCACTGCGTTTCGGCACAGCCCGTTCTTCGCCGAGCAGCTGACCGCATTCCAGGTGTGGC TCACCATGGGCGTGGAGAACCGAAACCCACCCGAACAGCTGCCCATCGTCCTGCAGGTGCTGTTAAGCCAAGTGCACCGGCTGAGAGCAT TGGACTTGCTTGGAAGATTTTTGGACCTGGGTCCCTGGGCAGTGAGCCTGATGATAGAGCAGCTGAGTCAGCTGATAACTGATCACCTGC AAATACAGCGTTGGCTCTTTAAAATGGACTCTGAGTTCCGAGGAAATGGGACTGCATTTTGTGATATTCCTTCCTACCTAAAGTGCTACA AATGGGTGCTAAAGGAGAGTAGCAGATATGGCCTTGAAGACTGGAGAAAGAAATGGGCACAAGAGCCAGCTTTGGTGAAGATCTCTGAGG AGCTGGCGGGCATTTTAGCACAGCACGCACAGCCAGTCAATGAGAAACGGTTCCCGACGTGGAGGAAATTCCTCCAAACATTTCTCAGTC AAGGGGGTGTGATCGAAGCATTCCCACCTGCAGACAATGTCACCAACCTCACAGTGGACATGCTGATAGAGCCCAACGGGAAAATCAGCG TGCTGTCGACAGGGGACCAGCTTCATGCTGAAAGCCCCTTCATCTCCTCTGGTACCACCGTGCCTCAGACCTCAGTGGATCCCCAAGTTC TCACTTATTTGTGCCTCCAAATTGGAAAAGCCTGCAGAATGAGAGATGTGGTTGGTTACTTTTCGATAGATCTGGTGACTTTTATAGATC CAAGCACCTTGGAACAACAGGTGTGGGCAACCGGCCTTAACCTCGCATATAGTGACCAGCTGGCCCTGACTCAACTCACCTTATACCTGA CAAACGGCCATCTGGATTGCAGTTTGAGCACCCTGGAAGTGCCCCGCTTTGTTCCAAAGGAAAGGAAGAAAACCAAATGCATGAGTGCGC TGTCAATGCCGATGCTGGCAACCAGTCGCTATGCAGTGATGACCACCCAGCTAAGACACAGCAATCTCTCACTGGTTTTCCACTATGTTT TTCTCCAGATCTGTAGGGCCCATGGCATTGGCTATGATGTTGAGGAAAGGCAAGGAACTGTTTTTATATTATATGAGCACCTGAAGAGAC ACAAGTTGGGAATGTTAACAATCGGCGAGGATCTCCAGGGGGTCCTCATGACCTTTGCTCGCCATCTCTTCATCATCCATCAAGAAATAT CAGCACCTAATATGCAAGGCGAGACCAATTTTAAGACCACCATTGCTGATATTGAAACTATTCTAAGAGTAACAAAGGAAAACAAAATGA GATTTGAAGAGGAGCAACAGTCCAAAGATGATAAAAACCTCTCTAAACCCAAGAAATGATCCTGGAATACAGTACATAACAATTTGGATC CCAGTCTGGAATAAAAAGGGCAATTTTTTTTTCTGTTAGAAATAAAAGCCAGGGGAAATTGGTTTGCTTTGTGTGCTAGGAGGTGAATCA GAACAGATTATAATGAAATGCTCTTTTTAAAACATTGTTTATTAAGTGATCTTATTTTATTTATTAAACCAAAACTTATTTGTGTTTTCA TTTGAGAGTGTTGAACAATCCCTTCTTCTTCTCAAACTCAGAAAAAAGTAATCTGATAAAAGAAGAAAGTTAAAAGTCTTACTGATATCA CCTCCGCATTTACTTCCTCATAGGCCTCAGGATTATGTAGCTTTTATTTTTTATGTTTTATAAAGTTTTCTCCTATTTCTAATAGTCCAT CGATCTTCTGCATTTATAGGTTTGAATAAAGGCTTAAGAATTGCTATTTGTCAAAACACAAATGCCTTTTTTTCAAAGCTTCAAATTATA TTGAAATTATATTTATATGAATTTTTAAGTGACTATCATTCATCGTGTTTTTGTTATACCAAGCCACTATTGTCTGCTATTGTTGCCATT TTTCAAAAAGTAGGATAAGCCAGCATCTAGTTAACCAAAGCATCAGAATGTATCTAGGTGGCAGTATCTGCTCTTAGTTTAAGATGGAGT GTAGCTCGAGCTCTGTAGCTTGAATAAACATTTGTATTCTCTAGTTCTCCATTTAATACAGCAGTAGGATTTTTTCAAGTTTAGTTCAAC ATTATACTACCTTTAAAAAGGCAGACTGTTAAGATTGTAGTAGTGCTGACTCTAACTTTCAGCATTCACTTCATAATTGTCCAAAAATAT TTCCACATCAGTGAGCTTTACTGAAGGGTGAAATAAAAGCAAATTACAACACCAAAACCATTATTGTTTTAAAGAATGACCTTTATGTCT ATAAAAATATTTTAGTGTATTGGGGAAAGGAATAGGATTTTTACCTGTGGAATTTCAATAATTTGTTAACTGTGATTCAGCCACAGGCTA >78229_78229_1_RPTOR-IQCH_RPTOR_chr17_78829347_ENST00000306801_IQCH_chr15_67692452_ENST00000335894_length(amino acids)=876AA_BP=482 MEVLERLLPRTPPPPPPLMESEMLQSPLLGLGEEDEADLTDWNLPLAFMKKRHCEKIEGSKSLAQSWRMKDRMKTVSVALVLCLNVGVDP PDVVKTTPCARLECWIDPLSMGPQKALETIGANLQKQYENWQPRARYKQSLDPTVDEVKKLCTSLRRNAKEERVLFHYNGHGVPRPTVNG EVWVFNKNYTQYIPLSIYDLQTWMGSPSIFVYDCSNAGLIVKSFKQFALQREQELEVAAINPNHPLAQMPLPPSMKNCIQLAACEATELL PMIPDLPADLFTSCLTTPIKIALRWFCMQKCVSLVPGVTLDLIEKIPGRLNDRRTPLGELNWIFTAITDTIAWNVLPRDLFQKLFRQDLL VASLFRNFLLAERIMRSYNCTPVSSPRLPPTYMHAMWQAWDLAVDICLSQLPTIIEEGTAFRHSPFFAEQLTAFQVWLTMGVENRNPPEQ LPIVLQVLLSQVHRLRALDLLGRFLDLGPWAVSLMIEQLSQLITDHLQIQRWLFKMDSEFRGNGTAFCDIPSYLKCYKWVLKESSRYGLE DWRKKWAQEPALVKISEELAGILAQHAQPVNEKRFPTWRKFLQTFLSQGGVIEAFPPADNVTNLTVDMLIEPNGKISVLSTGDQLHAESP FISSGTTVPQTSVDPQVLTYLCLQIGKACRMRDVVGYFSIDLVTFIDPSTLEQQVWATGLNLAYSDQLALTQLTLYLTNGHLDCSLSTLE VPRFVPKERKKTKCMSALSMPMLATSRYAVMTTQLRHSNLSLVFHYVFLQICRAHGIGYDVEERQGTVFILYEHLKRHKLGMLTIGEDLQ -------------------------------------------------------------- >78229_78229_2_RPTOR-IQCH_RPTOR_chr17_78829347_ENST00000306801_IQCH_chr15_67692452_ENST00000358767_length(transcript)=3934nt_BP=1760nt GAGAGCAGGGTCATCGTGAGGCCTGAAGTCTCTTACGCTTTTGGCAGCTCCCCTCGCAGCCCCTCTGGAAACGTACAGCCTCAGGAGCAG CCAGTGGCTTGGGACCTGGGGTGGTGTGTGTCTGCGGAGCTTCTTGGGCTGCCCCATTTCCTAGCGGCCCCCACCTCCCCACTTCCCGCT CAGAGTTAGAGATAAGGATCTCAGACTTTTGCCTGAGTAAGGGTCTCCGCACTCTTTATCCATTTGGTTTTCGATTTCCCGTTTTTGTTT CTTATTTCACCAATTCTGGTACACGCTAGTTTTTAAGGCTGGAGGTTCTCGAGCGCTTGCTGCCAAGGACTCCCCCACCCCCTCCCCCAC TGATGGAGTCCGAAATGCTGCAATCGCCTCTTCTGGGCCTGGGGGAGGAAGATGAGGCTGATCTTACAGACTGGAACCTACCTTTGGCTT TTATGAAAAAGAGGCACTGTGAGAAAATTGAAGGCTCCAAATCCTTAGCTCAGAGCTGGAGGATGAAGGATCGGATGAAGACAGTCAGTG TTGCCTTAGTTTTGTGCCTGAATGTTGGTGTGGACCCTCCCGATGTGGTGAAGACCACGCCCTGTGCACGCTTGGAATGCTGGATCGATC CTCTGTCGATGGGTCCTCAGAAAGCTCTGGAAACCATCGGTGCAAATTTACAGAAGCAGTACGAGAACTGGCAGCCAAGGGCCCGGTACA AGCAGAGCCTTGACCCAACTGTGGATGAAGTCAAGAAGCTCTGCACGTCCTTACGTCGCAACGCCAAGGAGGAGCGAGTCCTCTTTCACT ACAATGGCCACGGGGTGCCCCGGCCCACAGTCAACGGGGAGGTCTGGGTCTTCAACAAGAACTACACGCAGTACATCCCTCTGTCCATAT ATGACCTGCAGACGTGGATGGGCAGCCCGTCGATCTTCGTCTACGACTGCTCCAATGCTGGCTTGATCGTCAAGTCCTTCAAGCAGTTCG CACTACAGCGGGAGCAGGAGCTGGAGGTAGCTGCAATCAACCCAAATCACCCTCTTGCTCAGATGCCTTTGCCTCCGTCGATGAAAAACT GCATCCAGCTGGCAGCCTGCGAGGCCACCGAGCTGCTGCCCATGATCCCCGACCTCCCGGCTGACCTATTCACCTCCTGCCTCACCACCC CCATCAAGATCGCCCTGCGCTGGTTTTGCATGCAGAAATGTGTCAGTCTGGTGCCTGGCGTCACACTGGATTTGATAGAAAAGATCCCTG GCCGCCTGAACGACAGGAGGACGCCCCTGGGTGAACTGAACTGGATCTTCACAGCCATCACAGACACCATCGCGTGGAACGTGCTCCCCC GGGATCTCTTCCAAAAGCTCTTCAGACAGGACTTGCTGGTGGCTAGTCTGTTTCGAAATTTTTTATTGGCGGAAAGGATTATGAGGTCGT ATAACTGCACTCCCGTCAGCAGCCCGCGTCTGCCGCCCACGTACATGCACGCCATGTGGCAAGCCTGGGACCTGGCTGTTGACATCTGTC TGTCTCAGCTGCCGACGATCATCGAGGAAGGCACTGCGTTTCGGCACAGCCCGTTCTTCGCCGAGCAGCTGACCGCATTCCAGGTGTGGC TCACCATGGGCGTGGAGAACCGAAACCCACCCGAACAGCTGCCCATCGTCCTGCAGGTGCTGTTAAGCCAAGTGCACCGGCTGAGAGCAT TGGACTTGCTTGGAAGATTTTTGGACCTGGGTCCCTGGGCAGTGAGCCTGATGATAGAGCAGCTGAGTCAGCTGATAACTGATCACCTGC AAATACAGCGTTGGCTCTTTAAAATGGACTCTGAGTTCCGAGGAAATGGGACTGCATTTTGTGATATTCCTTCCTACCTAAAGTGCTACA AATGGGTGCTAAAGGAGAGTAGCAGATATGGCCTTGAAGACTGGAGAAAGAAATGGGCACAAGAGCCAGCTTTGGTGAAGATCTCTGAGG AGCTGGCGGGCATTTTAGCACAGCACGCACAGCCAGTCAATGAGAAACGGTTCCCGACGTGGAGGAAATTCCTCCAAACATTTCTCAGTC AAGGGGGTGTGATCGAAGCATTCCCACCTGCAGACAATGTCACCAACCTCACAGTGGACATGCTGATAGAGCCCAACGGGAAAATCAGCG TGCTGTCGACAGGGGACCAGCTTCATGCTGAAAGCCCCTTCATCTCCTCTGGTACCACCGTGCCTCAGACCTCAGTGGATCCCCAAGTTC TCACTTATTTGTGCCTCCAAATTGGAAAAGCCTGCAGAATGAGAGATGTGGTTGGTTACTTTTCGATAGATCTGGTGACTTTTATAGATC CAAGCACCTTGGAACAACAGGTGTGGGCAACCGGCCTTAACCTCGCATATAGTGACCAGCTGGCCCTGACTCAACTCACCTTATACCTGA CAAACGGCCATCTGGATTGCAGTTTGAGCACCCTGGAAGTGCCCCGCTTTGTTCCAAAGGAAAGGAAGAAAACCAAATGCATGAGTGCGC TGTCAATGCCGATGCTGGCAACCAGTCGCTATGCAGTGATGACCACCCAGCTAAGACACAGCAATCTCTCACTGGTTTTCCACTATGTTT TTCTCCAGATCTGTAGGGCCCATGGCATTGGCTATGATGTTGAGAACAATCGGCGAGGATCTCCAGGGGGTCCTCATGACCTTTGCTCGC CATCTCTTCATCATCCATCAAGAAATATCAGCACCTAATATGCAAGGCGAGACCAATTTTAAGACCACCATTGCTGATATTGAAACTATT CTAAGAGTAACAAAGGAAAACAAAATGAGATTTGAAGAGGAGCAACAGTCCAAAGATGATAAAAACCTCTCTAAACCCAAGAAATGATCC TGGAATACAGTACATAACAATTTGGATCCCAGTCTGGAATAAAAAGGGCAATTTTTTTTTCTGTTAGAAATAAAAGCCAGGGGAAATTGG TTTGCTTTGTGTGCTAGGAGGTGAATCAGAACAGATTATAATGAAATGCTCTTTTTAAAACATTGTTTATTAAGTGATCTTATTTTATTT ATTAAACCAAAACTTATTTGTGTTTTCATTTGAGAGTGTTGAACAATCCCTTCTTCTTCTCAAACTCAGAAAAAAGTAATCTGATAAAAG AAGAAAGTTAAAAGTCTTACTGATATCACCTCCGCATTTACTTCCTCATAGGCCTCAGGATTATGTAGCTTTTATTTTTTATGTTTTATA AAGTTTTCTCCTATTTCTAATAGTCCATCGATCTTCTGCATTTATAGGTTTGAATAAAGGCTTAAGAATTGCTATTTGTCAAAACACAAA TGCCTTTTTTTCAAAGCTTCAAATTATATTGAAATTATATTTATATGAATTTTTAAGTGACTATCATTCATCGTGTTTTTGTTATACCAA GCCACTATTGTCTGCTATTGTTGCCATTTTTCAAAAAGTAGGATAAGCCAGCATCTAGTTAACCAAAGCATCAGAATGTATCTAGGTGGC AGTATCTGCTCTTAGTTTAAGATGGAGTGTAGCTCGAGCTCTGTAGCTTGAATAAACATTTGTATTCTCTAGTTCTCCATTTAATACAGC AGTAGGATTTTTTCAAGTTTAGTTCAACATTATACTACCTTTAAAAAGGCAGACTGTTAAGATTGTAGTAGTGCTGACTCTAACTTTCAG CATTCACTTCATAATTGTCCAAAAATATTTCCACATCAGTGAGCTTTACTGAAGGGTGAAATAAAAGCAAATTACAACACCAAAACCATT ATTGTTTTAAAGAATGACCTTTATGTCTATAAAAATATTTTAGTGTATTGGGGAAAGGAATAGGATTTTTACCTGTGGAATTTCAATAAT >78229_78229_2_RPTOR-IQCH_RPTOR_chr17_78829347_ENST00000306801_IQCH_chr15_67692452_ENST00000358767_length(amino acids)=809AA_BP=482 MEVLERLLPRTPPPPPPLMESEMLQSPLLGLGEEDEADLTDWNLPLAFMKKRHCEKIEGSKSLAQSWRMKDRMKTVSVALVLCLNVGVDP PDVVKTTPCARLECWIDPLSMGPQKALETIGANLQKQYENWQPRARYKQSLDPTVDEVKKLCTSLRRNAKEERVLFHYNGHGVPRPTVNG EVWVFNKNYTQYIPLSIYDLQTWMGSPSIFVYDCSNAGLIVKSFKQFALQREQELEVAAINPNHPLAQMPLPPSMKNCIQLAACEATELL PMIPDLPADLFTSCLTTPIKIALRWFCMQKCVSLVPGVTLDLIEKIPGRLNDRRTPLGELNWIFTAITDTIAWNVLPRDLFQKLFRQDLL VASLFRNFLLAERIMRSYNCTPVSSPRLPPTYMHAMWQAWDLAVDICLSQLPTIIEEGTAFRHSPFFAEQLTAFQVWLTMGVENRNPPEQ LPIVLQVLLSQVHRLRALDLLGRFLDLGPWAVSLMIEQLSQLITDHLQIQRWLFKMDSEFRGNGTAFCDIPSYLKCYKWVLKESSRYGLE DWRKKWAQEPALVKISEELAGILAQHAQPVNEKRFPTWRKFLQTFLSQGGVIEAFPPADNVTNLTVDMLIEPNGKISVLSTGDQLHAESP FISSGTTVPQTSVDPQVLTYLCLQIGKACRMRDVVGYFSIDLVTFIDPSTLEQQVWATGLNLAYSDQLALTQLTLYLTNGHLDCSLSTLE -------------------------------------------------------------- >78229_78229_3_RPTOR-IQCH_RPTOR_chr17_78829347_ENST00000306801_IQCH_chr15_67692452_ENST00000360277_length(transcript)=3934nt_BP=1760nt GAGAGCAGGGTCATCGTGAGGCCTGAAGTCTCTTACGCTTTTGGCAGCTCCCCTCGCAGCCCCTCTGGAAACGTACAGCCTCAGGAGCAG CCAGTGGCTTGGGACCTGGGGTGGTGTGTGTCTGCGGAGCTTCTTGGGCTGCCCCATTTCCTAGCGGCCCCCACCTCCCCACTTCCCGCT CAGAGTTAGAGATAAGGATCTCAGACTTTTGCCTGAGTAAGGGTCTCCGCACTCTTTATCCATTTGGTTTTCGATTTCCCGTTTTTGTTT CTTATTTCACCAATTCTGGTACACGCTAGTTTTTAAGGCTGGAGGTTCTCGAGCGCTTGCTGCCAAGGACTCCCCCACCCCCTCCCCCAC TGATGGAGTCCGAAATGCTGCAATCGCCTCTTCTGGGCCTGGGGGAGGAAGATGAGGCTGATCTTACAGACTGGAACCTACCTTTGGCTT TTATGAAAAAGAGGCACTGTGAGAAAATTGAAGGCTCCAAATCCTTAGCTCAGAGCTGGAGGATGAAGGATCGGATGAAGACAGTCAGTG TTGCCTTAGTTTTGTGCCTGAATGTTGGTGTGGACCCTCCCGATGTGGTGAAGACCACGCCCTGTGCACGCTTGGAATGCTGGATCGATC CTCTGTCGATGGGTCCTCAGAAAGCTCTGGAAACCATCGGTGCAAATTTACAGAAGCAGTACGAGAACTGGCAGCCAAGGGCCCGGTACA AGCAGAGCCTTGACCCAACTGTGGATGAAGTCAAGAAGCTCTGCACGTCCTTACGTCGCAACGCCAAGGAGGAGCGAGTCCTCTTTCACT ACAATGGCCACGGGGTGCCCCGGCCCACAGTCAACGGGGAGGTCTGGGTCTTCAACAAGAACTACACGCAGTACATCCCTCTGTCCATAT ATGACCTGCAGACGTGGATGGGCAGCCCGTCGATCTTCGTCTACGACTGCTCCAATGCTGGCTTGATCGTCAAGTCCTTCAAGCAGTTCG CACTACAGCGGGAGCAGGAGCTGGAGGTAGCTGCAATCAACCCAAATCACCCTCTTGCTCAGATGCCTTTGCCTCCGTCGATGAAAAACT GCATCCAGCTGGCAGCCTGCGAGGCCACCGAGCTGCTGCCCATGATCCCCGACCTCCCGGCTGACCTATTCACCTCCTGCCTCACCACCC CCATCAAGATCGCCCTGCGCTGGTTTTGCATGCAGAAATGTGTCAGTCTGGTGCCTGGCGTCACACTGGATTTGATAGAAAAGATCCCTG GCCGCCTGAACGACAGGAGGACGCCCCTGGGTGAACTGAACTGGATCTTCACAGCCATCACAGACACCATCGCGTGGAACGTGCTCCCCC GGGATCTCTTCCAAAAGCTCTTCAGACAGGACTTGCTGGTGGCTAGTCTGTTTCGAAATTTTTTATTGGCGGAAAGGATTATGAGGTCGT ATAACTGCACTCCCGTCAGCAGCCCGCGTCTGCCGCCCACGTACATGCACGCCATGTGGCAAGCCTGGGACCTGGCTGTTGACATCTGTC TGTCTCAGCTGCCGACGATCATCGAGGAAGGCACTGCGTTTCGGCACAGCCCGTTCTTCGCCGAGCAGCTGACCGCATTCCAGGTGTGGC TCACCATGGGCGTGGAGAACCGAAACCCACCCGAACAGCTGCCCATCGTCCTGCAGGTGCTGTTAAGCCAAGTGCACCGGCTGAGAGCAT TGGACTTGCTTGGAAGATTTTTGGACCTGGGTCCCTGGGCAGTGAGCCTGATGATAGAGCAGCTGAGTCAGCTGATAACTGATCACCTGC AAATACAGCGTTGGCTCTTTAAAATGGACTCTGAGTTCCGAGGAAATGGGACTGCATTTTGTGATATTCCTTCCTACCTAAAGTGCTACA AATGGGTGCTAAAGGAGAGTAGCAGATATGGCCTTGAAGACTGGAGAAAGAAATGGGCACAAGAGCCAGCTTTGGTGAAGATCTCTGAGG AGCTGGCGGGCATTTTAGCACAGCACGCACAGCCAGTCAATGAGAAACGGTTCCCGACGTGGAGGAAATTCCTCCAAACATTTCTCAGTC AAGGGGGTGTGATCGAAGCATTCCCACCTGCAGACAATGTCACCAACCTCACAGTGGACATGCTGATAGAGCCCAACGGGAAAATCAGCG TGCTGTCGACAGGGGACCAGCTTCATGCTGAAAGCCCCTTCATCTCCTCTGGTACCACCGTGCCTCAGACCTCAGTGGATCCCCAAGTTC TCACTTATTTGTGCCTCCAAATTGGAAAAGCCTGCAGAATGAGAGATGTGGTTGGTTACTTTTCGATAGATCTGGTGACTTTTATAGATC CAAGCACCTTGGAACAACAGGTGTGGGCAACCGGCCTTAACCTCGCATATAGTGACCAGCTGGCCCTGACTCAACTCACCTTATACCTGA CAAACGGCCATCTGGATTGCAGTTTGAGCACCCTGGAAGTGCCCCGCTTTGTTCCAAAGGAAAGGAAGAAAACCAAATGCATGAGTGCGC TGTCAATGCCGATGCTGGCAACCAGTCGCTATGCAGTGATGACCACCCAGCTAAGACACAGCAATCTCTCACTGGTTTTCCACTATGTTT TTCTCCAGATCTGTAGGGCCCATGGCATTGGCTATGATGTTGAGAACAATCGGCGAGGATCTCCAGGGGGTCCTCATGACCTTTGCTCGC CATCTCTTCATCATCCATCAAGAAATATCAGCACCTAATATGCAAGGCGAGACCAATTTTAAGACCACCATTGCTGATATTGAAACTATT CTAAGAGTAACAAAGGAAAACAAAATGAGATTTGAAGAGGAGCAACAGTCCAAAGATGATAAAAACCTCTCTAAACCCAAGAAATGATCC TGGAATACAGTACATAACAATTTGGATCCCAGTCTGGAATAAAAAGGGCAATTTTTTTTTCTGTTAGAAATAAAAGCCAGGGGAAATTGG TTTGCTTTGTGTGCTAGGAGGTGAATCAGAACAGATTATAATGAAATGCTCTTTTTAAAACATTGTTTATTAAGTGATCTTATTTTATTT ATTAAACCAAAACTTATTTGTGTTTTCATTTGAGAGTGTTGAACAATCCCTTCTTCTTCTCAAACTCAGAAAAAAGTAATCTGATAAAAG AAGAAAGTTAAAAGTCTTACTGATATCACCTCCGCATTTACTTCCTCATAGGCCTCAGGATTATGTAGCTTTTATTTTTTATGTTTTATA AAGTTTTCTCCTATTTCTAATAGTCCATCGATCTTCTGCATTTATAGGTTTGAATAAAGGCTTAAGAATTGCTATTTGTCAAAACACAAA TGCCTTTTTTTCAAAGCTTCAAATTATATTGAAATTATATTTATATGAATTTTTAAGTGACTATCATTCATCGTGTTTTTGTTATACCAA GCCACTATTGTCTGCTATTGTTGCCATTTTTCAAAAAGTAGGATAAGCCAGCATCTAGTTAACCAAAGCATCAGAATGTATCTAGGTGGC AGTATCTGCTCTTAGTTTAAGATGGAGTGTAGCTCGAGCTCTGTAGCTTGAATAAACATTTGTATTCTCTAGTTCTCCATTTAATACAGC AGTAGGATTTTTTCAAGTTTAGTTCAACATTATACTACCTTTAAAAAGGCAGACTGTTAAGATTGTAGTAGTGCTGACTCTAACTTTCAG CATTCACTTCATAATTGTCCAAAAATATTTCCACATCAGTGAGCTTTACTGAAGGGTGAAATAAAAGCAAATTACAACACCAAAACCATT ATTGTTTTAAAGAATGACCTTTATGTCTATAAAAATATTTTAGTGTATTGGGGAAAGGAATAGGATTTTTACCTGTGGAATTTCAATAAT >78229_78229_3_RPTOR-IQCH_RPTOR_chr17_78829347_ENST00000306801_IQCH_chr15_67692452_ENST00000360277_length(amino acids)=809AA_BP=482 MEVLERLLPRTPPPPPPLMESEMLQSPLLGLGEEDEADLTDWNLPLAFMKKRHCEKIEGSKSLAQSWRMKDRMKTVSVALVLCLNVGVDP PDVVKTTPCARLECWIDPLSMGPQKALETIGANLQKQYENWQPRARYKQSLDPTVDEVKKLCTSLRRNAKEERVLFHYNGHGVPRPTVNG EVWVFNKNYTQYIPLSIYDLQTWMGSPSIFVYDCSNAGLIVKSFKQFALQREQELEVAAINPNHPLAQMPLPPSMKNCIQLAACEATELL PMIPDLPADLFTSCLTTPIKIALRWFCMQKCVSLVPGVTLDLIEKIPGRLNDRRTPLGELNWIFTAITDTIAWNVLPRDLFQKLFRQDLL VASLFRNFLLAERIMRSYNCTPVSSPRLPPTYMHAMWQAWDLAVDICLSQLPTIIEEGTAFRHSPFFAEQLTAFQVWLTMGVENRNPPEQ LPIVLQVLLSQVHRLRALDLLGRFLDLGPWAVSLMIEQLSQLITDHLQIQRWLFKMDSEFRGNGTAFCDIPSYLKCYKWVLKESSRYGLE DWRKKWAQEPALVKISEELAGILAQHAQPVNEKRFPTWRKFLQTFLSQGGVIEAFPPADNVTNLTVDMLIEPNGKISVLSTGDQLHAESP FISSGTTVPQTSVDPQVLTYLCLQIGKACRMRDVVGYFSIDLVTFIDPSTLEQQVWATGLNLAYSDQLALTQLTLYLTNGHLDCSLSTLE -------------------------------------------------------------- >78229_78229_4_RPTOR-IQCH_RPTOR_chr17_78829347_ENST00000306801_IQCH_chr15_67692452_ENST00000546225_length(transcript)=3996nt_BP=1760nt GAGAGCAGGGTCATCGTGAGGCCTGAAGTCTCTTACGCTTTTGGCAGCTCCCCTCGCAGCCCCTCTGGAAACGTACAGCCTCAGGAGCAG CCAGTGGCTTGGGACCTGGGGTGGTGTGTGTCTGCGGAGCTTCTTGGGCTGCCCCATTTCCTAGCGGCCCCCACCTCCCCACTTCCCGCT CAGAGTTAGAGATAAGGATCTCAGACTTTTGCCTGAGTAAGGGTCTCCGCACTCTTTATCCATTTGGTTTTCGATTTCCCGTTTTTGTTT CTTATTTCACCAATTCTGGTACACGCTAGTTTTTAAGGCTGGAGGTTCTCGAGCGCTTGCTGCCAAGGACTCCCCCACCCCCTCCCCCAC TGATGGAGTCCGAAATGCTGCAATCGCCTCTTCTGGGCCTGGGGGAGGAAGATGAGGCTGATCTTACAGACTGGAACCTACCTTTGGCTT TTATGAAAAAGAGGCACTGTGAGAAAATTGAAGGCTCCAAATCCTTAGCTCAGAGCTGGAGGATGAAGGATCGGATGAAGACAGTCAGTG TTGCCTTAGTTTTGTGCCTGAATGTTGGTGTGGACCCTCCCGATGTGGTGAAGACCACGCCCTGTGCACGCTTGGAATGCTGGATCGATC CTCTGTCGATGGGTCCTCAGAAAGCTCTGGAAACCATCGGTGCAAATTTACAGAAGCAGTACGAGAACTGGCAGCCAAGGGCCCGGTACA AGCAGAGCCTTGACCCAACTGTGGATGAAGTCAAGAAGCTCTGCACGTCCTTACGTCGCAACGCCAAGGAGGAGCGAGTCCTCTTTCACT ACAATGGCCACGGGGTGCCCCGGCCCACAGTCAACGGGGAGGTCTGGGTCTTCAACAAGAACTACACGCAGTACATCCCTCTGTCCATAT ATGACCTGCAGACGTGGATGGGCAGCCCGTCGATCTTCGTCTACGACTGCTCCAATGCTGGCTTGATCGTCAAGTCCTTCAAGCAGTTCG CACTACAGCGGGAGCAGGAGCTGGAGGTAGCTGCAATCAACCCAAATCACCCTCTTGCTCAGATGCCTTTGCCTCCGTCGATGAAAAACT GCATCCAGCTGGCAGCCTGCGAGGCCACCGAGCTGCTGCCCATGATCCCCGACCTCCCGGCTGACCTATTCACCTCCTGCCTCACCACCC CCATCAAGATCGCCCTGCGCTGGTTTTGCATGCAGAAATGTGTCAGTCTGGTGCCTGGCGTCACACTGGATTTGATAGAAAAGATCCCTG GCCGCCTGAACGACAGGAGGACGCCCCTGGGTGAACTGAACTGGATCTTCACAGCCATCACAGACACCATCGCGTGGAACGTGCTCCCCC GGGATCTCTTCCAAAAGCTCTTCAGACAGGACTTGCTGGTGGCTAGTCTGTTTCGAAATTTTTTATTGGCGGAAAGGATTATGAGGTCGT ATAACTGCACTCCCGTCAGCAGCCCGCGTCTGCCGCCCACGTACATGCACGCCATGTGGCAAGCCTGGGACCTGGCTGTTGACATCTGTC TGTCTCAGCTGCCGACGATCATCGAGGAAGGCACTGCGTTTCGGCACAGCCCGTTCTTCGCCGAGCAGCTGACCGCATTCCAGGTGTGGC TCACCATGGGCGTGGAGAACCGAAACCCACCCGAACAGCTGCCCATCGTCCTGCAGGTGCTGTTAAGCCAAGTGCACCGGCTGAGAGCAT TGGACTTGCTTGGAAGATTTTTGGACCTGGGTCCCTGGGCAGTGAGCCTGATGATAGAGCAGCTGAGTCAGCTGATAACTGATCACCTGC AAATACAGCGTTGGCTCTTTAAAATGGACTCTGAGTTCCGAGGAAATGGGACTGCATTTTGTGATATTCCTTCCTACCTAAAGTGCTACA AATGGGTGCTAAAGGAGAGTAGCAGATATGGCCTTGAAGACTGGAGAAAGAAATGGGCACAAGAGCCAGCTTTGGTGAAGATCTCTGAGG AGCTGGCGGGCATTTTAGCACAGCACGCACAGCCAGTCAATGAGAAACGGTTCCCGACGTGGAGGAAATTCCTCCAAACATTTCTCAGTC AAGGGGGTGTGATCGAAGCATTCCCACCTGCAGACAATGTCACCAACCTCACAGTGGACATGCTGATAGAGCCCAACGGGAAAATCAGCG TGCTGTCGACAGGGGACCAGCTTCATGCTGAAAGCCCCTTCATCTCCTCTGGTACCACCGTGCCTCAGACCTCAGTGGATCCCCAAGTTC TCACTTATTTGTGCCTCCAAATTGGAAAAGCCTGCAGAATGAGAGATGTGGTTGGTTACTTTTCGATAGATCTGGTGACTTTTATAGATC CAAGCACCTTGGAACAACAGGTGTGGGCAACCGGCCTTAACCTCGCATATAGTGACCAGCTGGCCCTGACTCAACTCACCTTATACCTGA CAAACGGCCATCTGGATTGCAGTTTGAGCACCCTGGAAGTGCCCCGCTTTGTTCCAAAGGAAAGGAAGAAAACCAAATGCATGAGTGCGC TGTCAATGCCGATGCTGGCAACCAGTCGCTATGCAGTGATGACCACCCAGCTAAGACACAGCAATCTCTCACTGGTTTTCCACTATGTTT TTCTCCAGATCTGTAGGGCCCATGGCATTGGCTATGATGTTGAGGAAAGGCAAGGAACTGTTTTTATATTATATGAGCACCTGAAGAGAC ACAAGTTGGGAATGTTAACAATCGGCGAGGATCTCCAGGGGGTCCTCATGACCTTTGCTCGCCATCTCTTCATCATCCATCAAGAAATAT CAGCACCTAATATGCAAGGCGAGACCAATTTTAAGACCACCATTGCTGATATTGAAACTATTCTAAGAGTAACAAAGGAAAACAAAATGA GATTTGAAGAGGAGCAACAGTCCAAAGATGATAAAAACCTCTCTAAACCCAAGAAATGATCCTGGAATACAGTACATAACAATTTGGATC CCAGTCTGGAATAAAAAGGGCAATTTTTTTTTCTGTTAGAAATAAAAGCCAGGGGAAATTGGTTTGCTTTGTGTGCTAGGAGGTGAATCA GAACAGATTATAATGAAATGCTCTTTTTAAAACATTGTTTATTAAGTGATCTTATTTTATTTATTAAACCAAAACTTATTTGTGTTTTCA TTTGAGAGTGTTGAACAATCCCTTCTTCTTCTCAAACTCAGAAAAAAGTAATCTGATAAAAGAAGAAAGTTAAAAGTCTTACTGATATCA CCTCCGCATTTACTTCCTCATAGGCCTCAGGATTATGTAGCTTTTATTTTTTATGTTTTATAAAGTTTTCTCCTATTTCTAATAGTCCAT CGATCTTCTGCATTTATAGGTTTGAATAAAGGCTTAAGAATTGCTATTTGTCAAAACACAAATGCCTTTTTTTCAAAGCTTCAAATTATA TTGAAATTATATTTATATGAATTTTTAAGTGACTATCATTCATCGTGTTTTTGTTATACCAAGCCACTATTGTCTGCTATTGTTGCCATT TTTCAAAAAGTAGGATAAGCCAGCATCTAGTTAACCAAAGCATCAGAATGTATCTAGGTGGCAGTATCTGCTCTTAGTTTAAGATGGAGT GTAGCTCGAGCTCTGTAGCTTGAATAAACATTTGTATTCTCTAGTTCTCCATTTAATACAGCAGTAGGATTTTTTCAAGTTTAGTTCAAC ATTATACTACCTTTAAAAAGGCAGACTGTTAAGATTGTAGTAGTGCTGACTCTAACTTTCAGCATTCACTTCATAATTGTCCAAAAATAT TTCCACATCAGTGAGCTTTACTGAAGGGTGAAATAAAAGCAAATTACAACACCAAAACCATTATTGTTTTAAAGAATGACCTTTATGTCT ATAAAAATATTTTAGTGTATTGGGGAAAGGAATAGGATTTTTACCTGTGGAATTTCAATAATTTGTTAACTGTGATTCAGCCACAGGCTA >78229_78229_4_RPTOR-IQCH_RPTOR_chr17_78829347_ENST00000306801_IQCH_chr15_67692452_ENST00000546225_length(amino acids)=876AA_BP=482 MEVLERLLPRTPPPPPPLMESEMLQSPLLGLGEEDEADLTDWNLPLAFMKKRHCEKIEGSKSLAQSWRMKDRMKTVSVALVLCLNVGVDP PDVVKTTPCARLECWIDPLSMGPQKALETIGANLQKQYENWQPRARYKQSLDPTVDEVKKLCTSLRRNAKEERVLFHYNGHGVPRPTVNG EVWVFNKNYTQYIPLSIYDLQTWMGSPSIFVYDCSNAGLIVKSFKQFALQREQELEVAAINPNHPLAQMPLPPSMKNCIQLAACEATELL PMIPDLPADLFTSCLTTPIKIALRWFCMQKCVSLVPGVTLDLIEKIPGRLNDRRTPLGELNWIFTAITDTIAWNVLPRDLFQKLFRQDLL VASLFRNFLLAERIMRSYNCTPVSSPRLPPTYMHAMWQAWDLAVDICLSQLPTIIEEGTAFRHSPFFAEQLTAFQVWLTMGVENRNPPEQ LPIVLQVLLSQVHRLRALDLLGRFLDLGPWAVSLMIEQLSQLITDHLQIQRWLFKMDSEFRGNGTAFCDIPSYLKCYKWVLKESSRYGLE DWRKKWAQEPALVKISEELAGILAQHAQPVNEKRFPTWRKFLQTFLSQGGVIEAFPPADNVTNLTVDMLIEPNGKISVLSTGDQLHAESP FISSGTTVPQTSVDPQVLTYLCLQIGKACRMRDVVGYFSIDLVTFIDPSTLEQQVWATGLNLAYSDQLALTQLTLYLTNGHLDCSLSTLE VPRFVPKERKKTKCMSALSMPMLATSRYAVMTTQLRHSNLSLVFHYVFLQICRAHGIGYDVEERQGTVFILYEHLKRHKLGMLTIGEDLQ -------------------------------------------------------------- >78229_78229_5_RPTOR-IQCH_RPTOR_chr17_78829347_ENST00000537330_IQCH_chr15_67692452_ENST00000335894_length(transcript)=4363nt_BP=2126nt AGGCCGCGGTGCATTCTGGGTCCTGGCAATATGGCGTCCTCCTTGATGGGCTGATGAGATGAGTTTCACTGTAGCTCCAAACCAGAGGGC AAAGCTCCCATGACCCAATAAGCCCACATTGTCCCTTTCCTCCGTGGTTCCGTGTCGCCCGTTTCTCAGGACTCGTTCTCAGGCAGGAGA GAGCCTCGGGGCTGAAGGCCAGGACCAGCCAGGCCGCGCGGACCTGAGGTTGAGGAACCGGGTGCAGGCGAGCACGATGGGCCGGTCGTG GCTCTGGTTGCAGCAGCTCAGACGAGTGCGGGACCCGCAGGGCTGAGAGTGGCTGGAGGAGACCCAGGGCCCTTTGAACCCGATCCCTTG GCCGGAGACCTCAGCCCAGTCGGCCCAGTGGGCGAACCGGCACCAAGAGCGGCCTGCCTGTCTTCGGAACTGCTGAGGCGGTGGAGGCCG AGAGCAGGGTCATCGTGAGGCCTGAAGTCTCTTACGCTTTTGGCAGCTCCCCTCGCAGCCCCTCTGGAAACGTACAGCCTCAGGAGCAGC CAGTGGCTTGGGACCTGGGGTGGTGTGTGTCTGCGGAGCTTCTTGGGCTGCCCCATTTCCTAGCGGCCCCCACCTCCCCACTTCCCGCTC AGAGTTAGAGATAAGGATCTCAGACTTTTGCCTGAGTAAGGGTCTCCGCACTCTTTATCCATTTGGTTTTCGATTTCCCGTTTTTGTTTC TTATTTCACCAATTCTGGTACACGCTAGTTTTTAAGGCTGGAGGTTCTCGAGCGCTTGCTGCCAAGGACTCCCCCACCCCCTCCCCCACT GATGGAGTCCGAAATGCTGCAATCGCCTCTTCTGGGCCTGGGGGAGGAAGATGAGGCTGATCTTACAGACTGGAACCTACCTTTGGCTTT TATGAAAAAGAGGCACTGTGAGAAAATTGAAGGCTCCAAATCCTTAGCTCAGAGCTGGAGGATGAAGGATCGGATGAAGACAGTCAGTGT TGCCTTAGTTTTGTGCCTGAATGTTGGTGTGGACCCTCCCGATGTGGTGAAGACCACGCCCTGTGCACGCTTGGAATGCTGGATCGGCCC GGTACAAGCAGAGCCTTGACCCAACTGTGGATGAAGTCAAGAAGCTCTGCACGTCCTTACGTCGCAACGCCAAGGAGGAGCGAGTCCTCT TTCACTACAATGGCCACGGGGTGCCCCGGCCCACAGTCAACGGGGAGGTCTGGGTCTTCAACAAGAACTACACGCAGTACATCCCTCTGT CCATATATGACCTGCAGACGTGGATGGGCAGCCCGTCGATCTTCGTCTACGACTGCTCCAATGCTGGCTTGATCGTCAAGTCCTTCAAGC AGTTCGCACTACAGCGGGAGCAGGAGCTGGAGGTAGCTGCAATCAACCCAAATCACCCTCTTGCTCAGATGCCTTTGCCTCCGTCGATGA AAAACTGCATCCAGCTGGCAGCCTGCGAGGCCACCGAGCTGCTGCCCATGATCCCCGACCTCCCGGCTGACCTATTCACCTCCTGCCTCA CCACCCCCATCAAGATCGCCCTGCGCTGGTTTTGCATGCAGAAATGTGTCAGTCTGGTGCCTGGCGTCACACTGGATTTGATAGAAAAGA TCCCTGGCCGCCTGAACGACAGGAGGACGCCCCTGGGTGAACTGAACTGGATCTTCACAGCCATCACAGACACCATCGCGTGGAACGTGC TCCCCCGGGATCTCTTCCAAAAGCTCTTCAGACAGGACTTGCTGGTGGCTAGTCTGTTTCGAAATTTTTTATTGGCGGAAAGGATTATGA GGTCGTATAACTGCACTCCCGTCAGCAGCCCGCGTCTGCCGCCCACGTACATGCACGCCATGTGGCAAGCCTGGGACCTGGCTGTTGACA TCTGTCTGTCTCAGCTGCCGACGATCATCGAGGAAGGCACTGCGTTTCGGCACAGCCCGTTCTTCGCCGAGCAGCTGACCGCATTCCAGG TGTGGCTCACCATGGGCGTGGAGAACCGAAACCCACCCGAACAGCTGCCCATCGTCCTGCAGGTGCTGTTAAGCCAAGTGCACCGGCTGA GAGCATTGGACTTGCTTGGAAGATTTTTGGACCTGGGTCCCTGGGCAGTGAGCCTGATGATAGAGCAGCTGAGTCAGCTGATAACTGATC ACCTGCAAATACAGCGTTGGCTCTTTAAAATGGACTCTGAGTTCCGAGGAAATGGGACTGCATTTTGTGATATTCCTTCCTACCTAAAGT GCTACAAATGGGTGCTAAAGGAGAGTAGCAGATATGGCCTTGAAGACTGGAGAAAGAAATGGGCACAAGAGCCAGCTTTGGTGAAGATCT CTGAGGAGCTGGCGGGCATTTTAGCACAGCACGCACAGCCAGTCAATGAGAAACGGTTCCCGACGTGGAGGAAATTCCTCCAAACATTTC TCAGTCAAGGGGGTGTGATCGAAGCATTCCCACCTGCAGACAATGTCACCAACCTCACAGTGGACATGCTGATAGAGCCCAACGGGAAAA TCAGCGTGCTGTCGACAGGGGACCAGCTTCATGCTGAAAGCCCCTTCATCTCCTCTGGTACCACCGTGCCTCAGACCTCAGTGGATCCCC AAGTTCTCACTTATTTGTGCCTCCAAATTGGAAAAGCCTGCAGAATGAGAGATGTGGTTGGTTACTTTTCGATAGATCTGGTGACTTTTA TAGATCCAAGCACCTTGGAACAACAGGTGTGGGCAACCGGCCTTAACCTCGCATATAGTGACCAGCTGGCCCTGACTCAACTCACCTTAT ACCTGACAAACGGCCATCTGGATTGCAGTTTGAGCACCCTGGAAGTGCCCCGCTTTGTTCCAAAGGAAAGGAAGAAAACCAAATGCATGA GTGCGCTGTCAATGCCGATGCTGGCAACCAGTCGCTATGCAGTGATGACCACCCAGCTAAGACACAGCAATCTCTCACTGGTTTTCCACT ATGTTTTTCTCCAGATCTGTAGGGCCCATGGCATTGGCTATGATGTTGAGGAAAGGCAAGGAACTGTTTTTATATTATATGAGCACCTGA AGAGACACAAGTTGGGAATGTTAACAATCGGCGAGGATCTCCAGGGGGTCCTCATGACCTTTGCTCGCCATCTCTTCATCATCCATCAAG AAATATCAGCACCTAATATGCAAGGCGAGACCAATTTTAAGACCACCATTGCTGATATTGAAACTATTCTAAGAGTAACAAAGGAAAACA AAATGAGATTTGAAGAGGAGCAACAGTCCAAAGATGATAAAAACCTCTCTAAACCCAAGAAATGATCCTGGAATACAGTACATAACAATT TGGATCCCAGTCTGGAATAAAAAGGGCAATTTTTTTTTCTGTTAGAAATAAAAGCCAGGGGAAATTGGTTTGCTTTGTGTGCTAGGAGGT GAATCAGAACAGATTATAATGAAATGCTCTTTTTAAAACATTGTTTATTAAGTGATCTTATTTTATTTATTAAACCAAAACTTATTTGTG TTTTCATTTGAGAGTGTTGAACAATCCCTTCTTCTTCTCAAACTCAGAAAAAAGTAATCTGATAAAAGAAGAAAGTTAAAAGTCTTACTG ATATCACCTCCGCATTTACTTCCTCATAGGCCTCAGGATTATGTAGCTTTTATTTTTTATGTTTTATAAAGTTTTCTCCTATTTCTAATA GTCCATCGATCTTCTGCATTTATAGGTTTGAATAAAGGCTTAAGAATTGCTATTTGTCAAAACACAAATGCCTTTTTTTCAAAGCTTCAA ATTATATTGAAATTATATTTATATGAATTTTTAAGTGACTATCATTCATCGTGTTTTTGTTATACCAAGCCACTATTGTCTGCTATTGTT GCCATTTTTCAAAAAGTAGGATAAGCCAGCATCTAGTTAACCAAAGCATCAGAATGTATCTAGGTGGCAGTATCTGCTCTTAGTTTAAGA TGGAGTGTAGCTCGAGCTCTGTAGCTTGAATAAACATTTGTATTCTCTAGTTCTCCATTTAATACAGCAGTAGGATTTTTTCAAGTTTAG TTCAACATTATACTACCTTTAAAAAGGCAGACTGTTAAGATTGTAGTAGTGCTGACTCTAACTTTCAGCATTCACTTCATAATTGTCCAA AAATATTTCCACATCAGTGAGCTTTACTGAAGGGTGAAATAAAAGCAAATTACAACACCAAAACCATTATTGTTTTAAAGAATGACCTTT ATGTCTATAAAAATATTTTAGTGTATTGGGGAAAGGAATAGGATTTTTACCTGTGGAATTTCAATAATTTGTTAACTGTGATTCAGCCAC >78229_78229_5_RPTOR-IQCH_RPTOR_chr17_78829347_ENST00000537330_IQCH_chr15_67692452_ENST00000335894_length(amino acids)=682AA_BP=288 MSIYDLQTWMGSPSIFVYDCSNAGLIVKSFKQFALQREQELEVAAINPNHPLAQMPLPPSMKNCIQLAACEATELLPMIPDLPADLFTSC LTTPIKIALRWFCMQKCVSLVPGVTLDLIEKIPGRLNDRRTPLGELNWIFTAITDTIAWNVLPRDLFQKLFRQDLLVASLFRNFLLAERI MRSYNCTPVSSPRLPPTYMHAMWQAWDLAVDICLSQLPTIIEEGTAFRHSPFFAEQLTAFQVWLTMGVENRNPPEQLPIVLQVLLSQVHR LRALDLLGRFLDLGPWAVSLMIEQLSQLITDHLQIQRWLFKMDSEFRGNGTAFCDIPSYLKCYKWVLKESSRYGLEDWRKKWAQEPALVK ISEELAGILAQHAQPVNEKRFPTWRKFLQTFLSQGGVIEAFPPADNVTNLTVDMLIEPNGKISVLSTGDQLHAESPFISSGTTVPQTSVD PQVLTYLCLQIGKACRMRDVVGYFSIDLVTFIDPSTLEQQVWATGLNLAYSDQLALTQLTLYLTNGHLDCSLSTLEVPRFVPKERKKTKC MSALSMPMLATSRYAVMTTQLRHSNLSLVFHYVFLQICRAHGIGYDVEERQGTVFILYEHLKRHKLGMLTIGEDLQGVLMTFARHLFIIH -------------------------------------------------------------- >78229_78229_6_RPTOR-IQCH_RPTOR_chr17_78829347_ENST00000537330_IQCH_chr15_67692452_ENST00000358767_length(transcript)=4300nt_BP=2126nt AGGCCGCGGTGCATTCTGGGTCCTGGCAATATGGCGTCCTCCTTGATGGGCTGATGAGATGAGTTTCACTGTAGCTCCAAACCAGAGGGC AAAGCTCCCATGACCCAATAAGCCCACATTGTCCCTTTCCTCCGTGGTTCCGTGTCGCCCGTTTCTCAGGACTCGTTCTCAGGCAGGAGA GAGCCTCGGGGCTGAAGGCCAGGACCAGCCAGGCCGCGCGGACCTGAGGTTGAGGAACCGGGTGCAGGCGAGCACGATGGGCCGGTCGTG GCTCTGGTTGCAGCAGCTCAGACGAGTGCGGGACCCGCAGGGCTGAGAGTGGCTGGAGGAGACCCAGGGCCCTTTGAACCCGATCCCTTG GCCGGAGACCTCAGCCCAGTCGGCCCAGTGGGCGAACCGGCACCAAGAGCGGCCTGCCTGTCTTCGGAACTGCTGAGGCGGTGGAGGCCG AGAGCAGGGTCATCGTGAGGCCTGAAGTCTCTTACGCTTTTGGCAGCTCCCCTCGCAGCCCCTCTGGAAACGTACAGCCTCAGGAGCAGC CAGTGGCTTGGGACCTGGGGTGGTGTGTGTCTGCGGAGCTTCTTGGGCTGCCCCATTTCCTAGCGGCCCCCACCTCCCCACTTCCCGCTC AGAGTTAGAGATAAGGATCTCAGACTTTTGCCTGAGTAAGGGTCTCCGCACTCTTTATCCATTTGGTTTTCGATTTCCCGTTTTTGTTTC TTATTTCACCAATTCTGGTACACGCTAGTTTTTAAGGCTGGAGGTTCTCGAGCGCTTGCTGCCAAGGACTCCCCCACCCCCTCCCCCACT GATGGAGTCCGAAATGCTGCAATCGCCTCTTCTGGGCCTGGGGGAGGAAGATGAGGCTGATCTTACAGACTGGAACCTACCTTTGGCTTT TATGAAAAAGAGGCACTGTGAGAAAATTGAAGGCTCCAAATCCTTAGCTCAGAGCTGGAGGATGAAGGATCGGATGAAGACAGTCAGTGT TGCCTTAGTTTTGTGCCTGAATGTTGGTGTGGACCCTCCCGATGTGGTGAAGACCACGCCCTGTGCACGCTTGGAATGCTGGATCGGCCC GGTACAAGCAGAGCCTTGACCCAACTGTGGATGAAGTCAAGAAGCTCTGCACGTCCTTACGTCGCAACGCCAAGGAGGAGCGAGTCCTCT TTCACTACAATGGCCACGGGGTGCCCCGGCCCACAGTCAACGGGGAGGTCTGGGTCTTCAACAAGAACTACACGCAGTACATCCCTCTGT CCATATATGACCTGCAGACGTGGATGGGCAGCCCGTCGATCTTCGTCTACGACTGCTCCAATGCTGGCTTGATCGTCAAGTCCTTCAAGC AGTTCGCACTACAGCGGGAGCAGGAGCTGGAGGTAGCTGCAATCAACCCAAATCACCCTCTTGCTCAGATGCCTTTGCCTCCGTCGATGA AAAACTGCATCCAGCTGGCAGCCTGCGAGGCCACCGAGCTGCTGCCCATGATCCCCGACCTCCCGGCTGACCTATTCACCTCCTGCCTCA CCACCCCCATCAAGATCGCCCTGCGCTGGTTTTGCATGCAGAAATGTGTCAGTCTGGTGCCTGGCGTCACACTGGATTTGATAGAAAAGA TCCCTGGCCGCCTGAACGACAGGAGGACGCCCCTGGGTGAACTGAACTGGATCTTCACAGCCATCACAGACACCATCGCGTGGAACGTGC TCCCCCGGGATCTCTTCCAAAAGCTCTTCAGACAGGACTTGCTGGTGGCTAGTCTGTTTCGAAATTTTTTATTGGCGGAAAGGATTATGA GGTCGTATAACTGCACTCCCGTCAGCAGCCCGCGTCTGCCGCCCACGTACATGCACGCCATGTGGCAAGCCTGGGACCTGGCTGTTGACA TCTGTCTGTCTCAGCTGCCGACGATCATCGAGGAAGGCACTGCGTTTCGGCACAGCCCGTTCTTCGCCGAGCAGCTGACCGCATTCCAGG TGTGGCTCACCATGGGCGTGGAGAACCGAAACCCACCCGAACAGCTGCCCATCGTCCTGCAGGTGCTGTTAAGCCAAGTGCACCGGCTGA GAGCATTGGACTTGCTTGGAAGATTTTTGGACCTGGGTCCCTGGGCAGTGAGCCTGATGATAGAGCAGCTGAGTCAGCTGATAACTGATC ACCTGCAAATACAGCGTTGGCTCTTTAAAATGGACTCTGAGTTCCGAGGAAATGGGACTGCATTTTGTGATATTCCTTCCTACCTAAAGT GCTACAAATGGGTGCTAAAGGAGAGTAGCAGATATGGCCTTGAAGACTGGAGAAAGAAATGGGCACAAGAGCCAGCTTTGGTGAAGATCT CTGAGGAGCTGGCGGGCATTTTAGCACAGCACGCACAGCCAGTCAATGAGAAACGGTTCCCGACGTGGAGGAAATTCCTCCAAACATTTC TCAGTCAAGGGGGTGTGATCGAAGCATTCCCACCTGCAGACAATGTCACCAACCTCACAGTGGACATGCTGATAGAGCCCAACGGGAAAA TCAGCGTGCTGTCGACAGGGGACCAGCTTCATGCTGAAAGCCCCTTCATCTCCTCTGGTACCACCGTGCCTCAGACCTCAGTGGATCCCC AAGTTCTCACTTATTTGTGCCTCCAAATTGGAAAAGCCTGCAGAATGAGAGATGTGGTTGGTTACTTTTCGATAGATCTGGTGACTTTTA TAGATCCAAGCACCTTGGAACAACAGGTGTGGGCAACCGGCCTTAACCTCGCATATAGTGACCAGCTGGCCCTGACTCAACTCACCTTAT ACCTGACAAACGGCCATCTGGATTGCAGTTTGAGCACCCTGGAAGTGCCCCGCTTTGTTCCAAAGGAAAGGAAGAAAACCAAATGCATGA GTGCGCTGTCAATGCCGATGCTGGCAACCAGTCGCTATGCAGTGATGACCACCCAGCTAAGACACAGCAATCTCTCACTGGTTTTCCACT ATGTTTTTCTCCAGATCTGTAGGGCCCATGGCATTGGCTATGATGTTGAGAACAATCGGCGAGGATCTCCAGGGGGTCCTCATGACCTTT GCTCGCCATCTCTTCATCATCCATCAAGAAATATCAGCACCTAATATGCAAGGCGAGACCAATTTTAAGACCACCATTGCTGATATTGAA ACTATTCTAAGAGTAACAAAGGAAAACAAAATGAGATTTGAAGAGGAGCAACAGTCCAAAGATGATAAAAACCTCTCTAAACCCAAGAAA TGATCCTGGAATACAGTACATAACAATTTGGATCCCAGTCTGGAATAAAAAGGGCAATTTTTTTTTCTGTTAGAAATAAAAGCCAGGGGA AATTGGTTTGCTTTGTGTGCTAGGAGGTGAATCAGAACAGATTATAATGAAATGCTCTTTTTAAAACATTGTTTATTAAGTGATCTTATT TTATTTATTAAACCAAAACTTATTTGTGTTTTCATTTGAGAGTGTTGAACAATCCCTTCTTCTTCTCAAACTCAGAAAAAAGTAATCTGA TAAAAGAAGAAAGTTAAAAGTCTTACTGATATCACCTCCGCATTTACTTCCTCATAGGCCTCAGGATTATGTAGCTTTTATTTTTTATGT TTTATAAAGTTTTCTCCTATTTCTAATAGTCCATCGATCTTCTGCATTTATAGGTTTGAATAAAGGCTTAAGAATTGCTATTTGTCAAAA CACAAATGCCTTTTTTTCAAAGCTTCAAATTATATTGAAATTATATTTATATGAATTTTTAAGTGACTATCATTCATCGTGTTTTTGTTA TACCAAGCCACTATTGTCTGCTATTGTTGCCATTTTTCAAAAAGTAGGATAAGCCAGCATCTAGTTAACCAAAGCATCAGAATGTATCTA GGTGGCAGTATCTGCTCTTAGTTTAAGATGGAGTGTAGCTCGAGCTCTGTAGCTTGAATAAACATTTGTATTCTCTAGTTCTCCATTTAA TACAGCAGTAGGATTTTTTCAAGTTTAGTTCAACATTATACTACCTTTAAAAAGGCAGACTGTTAAGATTGTAGTAGTGCTGACTCTAAC TTTCAGCATTCACTTCATAATTGTCCAAAAATATTTCCACATCAGTGAGCTTTACTGAAGGGTGAAATAAAAGCAAATTACAACACCAAA ACCATTATTGTTTTAAAGAATGACCTTTATGTCTATAAAAATATTTTAGTGTATTGGGGAAAGGAATAGGATTTTTACCTGTGGAATTTC >78229_78229_6_RPTOR-IQCH_RPTOR_chr17_78829347_ENST00000537330_IQCH_chr15_67692452_ENST00000358767_length(amino acids)=615AA_BP=288 MSIYDLQTWMGSPSIFVYDCSNAGLIVKSFKQFALQREQELEVAAINPNHPLAQMPLPPSMKNCIQLAACEATELLPMIPDLPADLFTSC LTTPIKIALRWFCMQKCVSLVPGVTLDLIEKIPGRLNDRRTPLGELNWIFTAITDTIAWNVLPRDLFQKLFRQDLLVASLFRNFLLAERI MRSYNCTPVSSPRLPPTYMHAMWQAWDLAVDICLSQLPTIIEEGTAFRHSPFFAEQLTAFQVWLTMGVENRNPPEQLPIVLQVLLSQVHR LRALDLLGRFLDLGPWAVSLMIEQLSQLITDHLQIQRWLFKMDSEFRGNGTAFCDIPSYLKCYKWVLKESSRYGLEDWRKKWAQEPALVK ISEELAGILAQHAQPVNEKRFPTWRKFLQTFLSQGGVIEAFPPADNVTNLTVDMLIEPNGKISVLSTGDQLHAESPFISSGTTVPQTSVD PQVLTYLCLQIGKACRMRDVVGYFSIDLVTFIDPSTLEQQVWATGLNLAYSDQLALTQLTLYLTNGHLDCSLSTLEVPRFVPKERKKTKC -------------------------------------------------------------- >78229_78229_7_RPTOR-IQCH_RPTOR_chr17_78829347_ENST00000537330_IQCH_chr15_67692452_ENST00000360277_length(transcript)=4300nt_BP=2126nt AGGCCGCGGTGCATTCTGGGTCCTGGCAATATGGCGTCCTCCTTGATGGGCTGATGAGATGAGTTTCACTGTAGCTCCAAACCAGAGGGC AAAGCTCCCATGACCCAATAAGCCCACATTGTCCCTTTCCTCCGTGGTTCCGTGTCGCCCGTTTCTCAGGACTCGTTCTCAGGCAGGAGA GAGCCTCGGGGCTGAAGGCCAGGACCAGCCAGGCCGCGCGGACCTGAGGTTGAGGAACCGGGTGCAGGCGAGCACGATGGGCCGGTCGTG GCTCTGGTTGCAGCAGCTCAGACGAGTGCGGGACCCGCAGGGCTGAGAGTGGCTGGAGGAGACCCAGGGCCCTTTGAACCCGATCCCTTG GCCGGAGACCTCAGCCCAGTCGGCCCAGTGGGCGAACCGGCACCAAGAGCGGCCTGCCTGTCTTCGGAACTGCTGAGGCGGTGGAGGCCG AGAGCAGGGTCATCGTGAGGCCTGAAGTCTCTTACGCTTTTGGCAGCTCCCCTCGCAGCCCCTCTGGAAACGTACAGCCTCAGGAGCAGC CAGTGGCTTGGGACCTGGGGTGGTGTGTGTCTGCGGAGCTTCTTGGGCTGCCCCATTTCCTAGCGGCCCCCACCTCCCCACTTCCCGCTC AGAGTTAGAGATAAGGATCTCAGACTTTTGCCTGAGTAAGGGTCTCCGCACTCTTTATCCATTTGGTTTTCGATTTCCCGTTTTTGTTTC TTATTTCACCAATTCTGGTACACGCTAGTTTTTAAGGCTGGAGGTTCTCGAGCGCTTGCTGCCAAGGACTCCCCCACCCCCTCCCCCACT GATGGAGTCCGAAATGCTGCAATCGCCTCTTCTGGGCCTGGGGGAGGAAGATGAGGCTGATCTTACAGACTGGAACCTACCTTTGGCTTT TATGAAAAAGAGGCACTGTGAGAAAATTGAAGGCTCCAAATCCTTAGCTCAGAGCTGGAGGATGAAGGATCGGATGAAGACAGTCAGTGT TGCCTTAGTTTTGTGCCTGAATGTTGGTGTGGACCCTCCCGATGTGGTGAAGACCACGCCCTGTGCACGCTTGGAATGCTGGATCGGCCC GGTACAAGCAGAGCCTTGACCCAACTGTGGATGAAGTCAAGAAGCTCTGCACGTCCTTACGTCGCAACGCCAAGGAGGAGCGAGTCCTCT TTCACTACAATGGCCACGGGGTGCCCCGGCCCACAGTCAACGGGGAGGTCTGGGTCTTCAACAAGAACTACACGCAGTACATCCCTCTGT CCATATATGACCTGCAGACGTGGATGGGCAGCCCGTCGATCTTCGTCTACGACTGCTCCAATGCTGGCTTGATCGTCAAGTCCTTCAAGC AGTTCGCACTACAGCGGGAGCAGGAGCTGGAGGTAGCTGCAATCAACCCAAATCACCCTCTTGCTCAGATGCCTTTGCCTCCGTCGATGA AAAACTGCATCCAGCTGGCAGCCTGCGAGGCCACCGAGCTGCTGCCCATGATCCCCGACCTCCCGGCTGACCTATTCACCTCCTGCCTCA CCACCCCCATCAAGATCGCCCTGCGCTGGTTTTGCATGCAGAAATGTGTCAGTCTGGTGCCTGGCGTCACACTGGATTTGATAGAAAAGA TCCCTGGCCGCCTGAACGACAGGAGGACGCCCCTGGGTGAACTGAACTGGATCTTCACAGCCATCACAGACACCATCGCGTGGAACGTGC TCCCCCGGGATCTCTTCCAAAAGCTCTTCAGACAGGACTTGCTGGTGGCTAGTCTGTTTCGAAATTTTTTATTGGCGGAAAGGATTATGA GGTCGTATAACTGCACTCCCGTCAGCAGCCCGCGTCTGCCGCCCACGTACATGCACGCCATGTGGCAAGCCTGGGACCTGGCTGTTGACA TCTGTCTGTCTCAGCTGCCGACGATCATCGAGGAAGGCACTGCGTTTCGGCACAGCCCGTTCTTCGCCGAGCAGCTGACCGCATTCCAGG TGTGGCTCACCATGGGCGTGGAGAACCGAAACCCACCCGAACAGCTGCCCATCGTCCTGCAGGTGCTGTTAAGCCAAGTGCACCGGCTGA GAGCATTGGACTTGCTTGGAAGATTTTTGGACCTGGGTCCCTGGGCAGTGAGCCTGATGATAGAGCAGCTGAGTCAGCTGATAACTGATC ACCTGCAAATACAGCGTTGGCTCTTTAAAATGGACTCTGAGTTCCGAGGAAATGGGACTGCATTTTGTGATATTCCTTCCTACCTAAAGT GCTACAAATGGGTGCTAAAGGAGAGTAGCAGATATGGCCTTGAAGACTGGAGAAAGAAATGGGCACAAGAGCCAGCTTTGGTGAAGATCT CTGAGGAGCTGGCGGGCATTTTAGCACAGCACGCACAGCCAGTCAATGAGAAACGGTTCCCGACGTGGAGGAAATTCCTCCAAACATTTC TCAGTCAAGGGGGTGTGATCGAAGCATTCCCACCTGCAGACAATGTCACCAACCTCACAGTGGACATGCTGATAGAGCCCAACGGGAAAA TCAGCGTGCTGTCGACAGGGGACCAGCTTCATGCTGAAAGCCCCTTCATCTCCTCTGGTACCACCGTGCCTCAGACCTCAGTGGATCCCC AAGTTCTCACTTATTTGTGCCTCCAAATTGGAAAAGCCTGCAGAATGAGAGATGTGGTTGGTTACTTTTCGATAGATCTGGTGACTTTTA TAGATCCAAGCACCTTGGAACAACAGGTGTGGGCAACCGGCCTTAACCTCGCATATAGTGACCAGCTGGCCCTGACTCAACTCACCTTAT ACCTGACAAACGGCCATCTGGATTGCAGTTTGAGCACCCTGGAAGTGCCCCGCTTTGTTCCAAAGGAAAGGAAGAAAACCAAATGCATGA GTGCGCTGTCAATGCCGATGCTGGCAACCAGTCGCTATGCAGTGATGACCACCCAGCTAAGACACAGCAATCTCTCACTGGTTTTCCACT ATGTTTTTCTCCAGATCTGTAGGGCCCATGGCATTGGCTATGATGTTGAGAACAATCGGCGAGGATCTCCAGGGGGTCCTCATGACCTTT GCTCGCCATCTCTTCATCATCCATCAAGAAATATCAGCACCTAATATGCAAGGCGAGACCAATTTTAAGACCACCATTGCTGATATTGAA ACTATTCTAAGAGTAACAAAGGAAAACAAAATGAGATTTGAAGAGGAGCAACAGTCCAAAGATGATAAAAACCTCTCTAAACCCAAGAAA TGATCCTGGAATACAGTACATAACAATTTGGATCCCAGTCTGGAATAAAAAGGGCAATTTTTTTTTCTGTTAGAAATAAAAGCCAGGGGA AATTGGTTTGCTTTGTGTGCTAGGAGGTGAATCAGAACAGATTATAATGAAATGCTCTTTTTAAAACATTGTTTATTAAGTGATCTTATT TTATTTATTAAACCAAAACTTATTTGTGTTTTCATTTGAGAGTGTTGAACAATCCCTTCTTCTTCTCAAACTCAGAAAAAAGTAATCTGA TAAAAGAAGAAAGTTAAAAGTCTTACTGATATCACCTCCGCATTTACTTCCTCATAGGCCTCAGGATTATGTAGCTTTTATTTTTTATGT TTTATAAAGTTTTCTCCTATTTCTAATAGTCCATCGATCTTCTGCATTTATAGGTTTGAATAAAGGCTTAAGAATTGCTATTTGTCAAAA CACAAATGCCTTTTTTTCAAAGCTTCAAATTATATTGAAATTATATTTATATGAATTTTTAAGTGACTATCATTCATCGTGTTTTTGTTA TACCAAGCCACTATTGTCTGCTATTGTTGCCATTTTTCAAAAAGTAGGATAAGCCAGCATCTAGTTAACCAAAGCATCAGAATGTATCTA GGTGGCAGTATCTGCTCTTAGTTTAAGATGGAGTGTAGCTCGAGCTCTGTAGCTTGAATAAACATTTGTATTCTCTAGTTCTCCATTTAA TACAGCAGTAGGATTTTTTCAAGTTTAGTTCAACATTATACTACCTTTAAAAAGGCAGACTGTTAAGATTGTAGTAGTGCTGACTCTAAC TTTCAGCATTCACTTCATAATTGTCCAAAAATATTTCCACATCAGTGAGCTTTACTGAAGGGTGAAATAAAAGCAAATTACAACACCAAA ACCATTATTGTTTTAAAGAATGACCTTTATGTCTATAAAAATATTTTAGTGTATTGGGGAAAGGAATAGGATTTTTACCTGTGGAATTTC >78229_78229_7_RPTOR-IQCH_RPTOR_chr17_78829347_ENST00000537330_IQCH_chr15_67692452_ENST00000360277_length(amino acids)=615AA_BP=288 MSIYDLQTWMGSPSIFVYDCSNAGLIVKSFKQFALQREQELEVAAINPNHPLAQMPLPPSMKNCIQLAACEATELLPMIPDLPADLFTSC LTTPIKIALRWFCMQKCVSLVPGVTLDLIEKIPGRLNDRRTPLGELNWIFTAITDTIAWNVLPRDLFQKLFRQDLLVASLFRNFLLAERI MRSYNCTPVSSPRLPPTYMHAMWQAWDLAVDICLSQLPTIIEEGTAFRHSPFFAEQLTAFQVWLTMGVENRNPPEQLPIVLQVLLSQVHR LRALDLLGRFLDLGPWAVSLMIEQLSQLITDHLQIQRWLFKMDSEFRGNGTAFCDIPSYLKCYKWVLKESSRYGLEDWRKKWAQEPALVK ISEELAGILAQHAQPVNEKRFPTWRKFLQTFLSQGGVIEAFPPADNVTNLTVDMLIEPNGKISVLSTGDQLHAESPFISSGTTVPQTSVD PQVLTYLCLQIGKACRMRDVVGYFSIDLVTFIDPSTLEQQVWATGLNLAYSDQLALTQLTLYLTNGHLDCSLSTLEVPRFVPKERKKTKC -------------------------------------------------------------- >78229_78229_8_RPTOR-IQCH_RPTOR_chr17_78829347_ENST00000537330_IQCH_chr15_67692452_ENST00000546225_length(transcript)=4362nt_BP=2126nt AGGCCGCGGTGCATTCTGGGTCCTGGCAATATGGCGTCCTCCTTGATGGGCTGATGAGATGAGTTTCACTGTAGCTCCAAACCAGAGGGC AAAGCTCCCATGACCCAATAAGCCCACATTGTCCCTTTCCTCCGTGGTTCCGTGTCGCCCGTTTCTCAGGACTCGTTCTCAGGCAGGAGA GAGCCTCGGGGCTGAAGGCCAGGACCAGCCAGGCCGCGCGGACCTGAGGTTGAGGAACCGGGTGCAGGCGAGCACGATGGGCCGGTCGTG GCTCTGGTTGCAGCAGCTCAGACGAGTGCGGGACCCGCAGGGCTGAGAGTGGCTGGAGGAGACCCAGGGCCCTTTGAACCCGATCCCTTG GCCGGAGACCTCAGCCCAGTCGGCCCAGTGGGCGAACCGGCACCAAGAGCGGCCTGCCTGTCTTCGGAACTGCTGAGGCGGTGGAGGCCG AGAGCAGGGTCATCGTGAGGCCTGAAGTCTCTTACGCTTTTGGCAGCTCCCCTCGCAGCCCCTCTGGAAACGTACAGCCTCAGGAGCAGC CAGTGGCTTGGGACCTGGGGTGGTGTGTGTCTGCGGAGCTTCTTGGGCTGCCCCATTTCCTAGCGGCCCCCACCTCCCCACTTCCCGCTC AGAGTTAGAGATAAGGATCTCAGACTTTTGCCTGAGTAAGGGTCTCCGCACTCTTTATCCATTTGGTTTTCGATTTCCCGTTTTTGTTTC TTATTTCACCAATTCTGGTACACGCTAGTTTTTAAGGCTGGAGGTTCTCGAGCGCTTGCTGCCAAGGACTCCCCCACCCCCTCCCCCACT GATGGAGTCCGAAATGCTGCAATCGCCTCTTCTGGGCCTGGGGGAGGAAGATGAGGCTGATCTTACAGACTGGAACCTACCTTTGGCTTT TATGAAAAAGAGGCACTGTGAGAAAATTGAAGGCTCCAAATCCTTAGCTCAGAGCTGGAGGATGAAGGATCGGATGAAGACAGTCAGTGT TGCCTTAGTTTTGTGCCTGAATGTTGGTGTGGACCCTCCCGATGTGGTGAAGACCACGCCCTGTGCACGCTTGGAATGCTGGATCGGCCC GGTACAAGCAGAGCCTTGACCCAACTGTGGATGAAGTCAAGAAGCTCTGCACGTCCTTACGTCGCAACGCCAAGGAGGAGCGAGTCCTCT TTCACTACAATGGCCACGGGGTGCCCCGGCCCACAGTCAACGGGGAGGTCTGGGTCTTCAACAAGAACTACACGCAGTACATCCCTCTGT CCATATATGACCTGCAGACGTGGATGGGCAGCCCGTCGATCTTCGTCTACGACTGCTCCAATGCTGGCTTGATCGTCAAGTCCTTCAAGC AGTTCGCACTACAGCGGGAGCAGGAGCTGGAGGTAGCTGCAATCAACCCAAATCACCCTCTTGCTCAGATGCCTTTGCCTCCGTCGATGA AAAACTGCATCCAGCTGGCAGCCTGCGAGGCCACCGAGCTGCTGCCCATGATCCCCGACCTCCCGGCTGACCTATTCACCTCCTGCCTCA CCACCCCCATCAAGATCGCCCTGCGCTGGTTTTGCATGCAGAAATGTGTCAGTCTGGTGCCTGGCGTCACACTGGATTTGATAGAAAAGA TCCCTGGCCGCCTGAACGACAGGAGGACGCCCCTGGGTGAACTGAACTGGATCTTCACAGCCATCACAGACACCATCGCGTGGAACGTGC TCCCCCGGGATCTCTTCCAAAAGCTCTTCAGACAGGACTTGCTGGTGGCTAGTCTGTTTCGAAATTTTTTATTGGCGGAAAGGATTATGA GGTCGTATAACTGCACTCCCGTCAGCAGCCCGCGTCTGCCGCCCACGTACATGCACGCCATGTGGCAAGCCTGGGACCTGGCTGTTGACA TCTGTCTGTCTCAGCTGCCGACGATCATCGAGGAAGGCACTGCGTTTCGGCACAGCCCGTTCTTCGCCGAGCAGCTGACCGCATTCCAGG TGTGGCTCACCATGGGCGTGGAGAACCGAAACCCACCCGAACAGCTGCCCATCGTCCTGCAGGTGCTGTTAAGCCAAGTGCACCGGCTGA GAGCATTGGACTTGCTTGGAAGATTTTTGGACCTGGGTCCCTGGGCAGTGAGCCTGATGATAGAGCAGCTGAGTCAGCTGATAACTGATC ACCTGCAAATACAGCGTTGGCTCTTTAAAATGGACTCTGAGTTCCGAGGAAATGGGACTGCATTTTGTGATATTCCTTCCTACCTAAAGT GCTACAAATGGGTGCTAAAGGAGAGTAGCAGATATGGCCTTGAAGACTGGAGAAAGAAATGGGCACAAGAGCCAGCTTTGGTGAAGATCT CTGAGGAGCTGGCGGGCATTTTAGCACAGCACGCACAGCCAGTCAATGAGAAACGGTTCCCGACGTGGAGGAAATTCCTCCAAACATTTC TCAGTCAAGGGGGTGTGATCGAAGCATTCCCACCTGCAGACAATGTCACCAACCTCACAGTGGACATGCTGATAGAGCCCAACGGGAAAA TCAGCGTGCTGTCGACAGGGGACCAGCTTCATGCTGAAAGCCCCTTCATCTCCTCTGGTACCACCGTGCCTCAGACCTCAGTGGATCCCC AAGTTCTCACTTATTTGTGCCTCCAAATTGGAAAAGCCTGCAGAATGAGAGATGTGGTTGGTTACTTTTCGATAGATCTGGTGACTTTTA TAGATCCAAGCACCTTGGAACAACAGGTGTGGGCAACCGGCCTTAACCTCGCATATAGTGACCAGCTGGCCCTGACTCAACTCACCTTAT ACCTGACAAACGGCCATCTGGATTGCAGTTTGAGCACCCTGGAAGTGCCCCGCTTTGTTCCAAAGGAAAGGAAGAAAACCAAATGCATGA GTGCGCTGTCAATGCCGATGCTGGCAACCAGTCGCTATGCAGTGATGACCACCCAGCTAAGACACAGCAATCTCTCACTGGTTTTCCACT ATGTTTTTCTCCAGATCTGTAGGGCCCATGGCATTGGCTATGATGTTGAGGAAAGGCAAGGAACTGTTTTTATATTATATGAGCACCTGA AGAGACACAAGTTGGGAATGTTAACAATCGGCGAGGATCTCCAGGGGGTCCTCATGACCTTTGCTCGCCATCTCTTCATCATCCATCAAG AAATATCAGCACCTAATATGCAAGGCGAGACCAATTTTAAGACCACCATTGCTGATATTGAAACTATTCTAAGAGTAACAAAGGAAAACA AAATGAGATTTGAAGAGGAGCAACAGTCCAAAGATGATAAAAACCTCTCTAAACCCAAGAAATGATCCTGGAATACAGTACATAACAATT TGGATCCCAGTCTGGAATAAAAAGGGCAATTTTTTTTTCTGTTAGAAATAAAAGCCAGGGGAAATTGGTTTGCTTTGTGTGCTAGGAGGT GAATCAGAACAGATTATAATGAAATGCTCTTTTTAAAACATTGTTTATTAAGTGATCTTATTTTATTTATTAAACCAAAACTTATTTGTG TTTTCATTTGAGAGTGTTGAACAATCCCTTCTTCTTCTCAAACTCAGAAAAAAGTAATCTGATAAAAGAAGAAAGTTAAAAGTCTTACTG ATATCACCTCCGCATTTACTTCCTCATAGGCCTCAGGATTATGTAGCTTTTATTTTTTATGTTTTATAAAGTTTTCTCCTATTTCTAATA GTCCATCGATCTTCTGCATTTATAGGTTTGAATAAAGGCTTAAGAATTGCTATTTGTCAAAACACAAATGCCTTTTTTTCAAAGCTTCAA ATTATATTGAAATTATATTTATATGAATTTTTAAGTGACTATCATTCATCGTGTTTTTGTTATACCAAGCCACTATTGTCTGCTATTGTT GCCATTTTTCAAAAAGTAGGATAAGCCAGCATCTAGTTAACCAAAGCATCAGAATGTATCTAGGTGGCAGTATCTGCTCTTAGTTTAAGA TGGAGTGTAGCTCGAGCTCTGTAGCTTGAATAAACATTTGTATTCTCTAGTTCTCCATTTAATACAGCAGTAGGATTTTTTCAAGTTTAG TTCAACATTATACTACCTTTAAAAAGGCAGACTGTTAAGATTGTAGTAGTGCTGACTCTAACTTTCAGCATTCACTTCATAATTGTCCAA AAATATTTCCACATCAGTGAGCTTTACTGAAGGGTGAAATAAAAGCAAATTACAACACCAAAACCATTATTGTTTTAAAGAATGACCTTT ATGTCTATAAAAATATTTTAGTGTATTGGGGAAAGGAATAGGATTTTTACCTGTGGAATTTCAATAATTTGTTAACTGTGATTCAGCCAC >78229_78229_8_RPTOR-IQCH_RPTOR_chr17_78829347_ENST00000537330_IQCH_chr15_67692452_ENST00000546225_length(amino acids)=682AA_BP=288 MSIYDLQTWMGSPSIFVYDCSNAGLIVKSFKQFALQREQELEVAAINPNHPLAQMPLPPSMKNCIQLAACEATELLPMIPDLPADLFTSC LTTPIKIALRWFCMQKCVSLVPGVTLDLIEKIPGRLNDRRTPLGELNWIFTAITDTIAWNVLPRDLFQKLFRQDLLVASLFRNFLLAERI MRSYNCTPVSSPRLPPTYMHAMWQAWDLAVDICLSQLPTIIEEGTAFRHSPFFAEQLTAFQVWLTMGVENRNPPEQLPIVLQVLLSQVHR LRALDLLGRFLDLGPWAVSLMIEQLSQLITDHLQIQRWLFKMDSEFRGNGTAFCDIPSYLKCYKWVLKESSRYGLEDWRKKWAQEPALVK ISEELAGILAQHAQPVNEKRFPTWRKFLQTFLSQGGVIEAFPPADNVTNLTVDMLIEPNGKISVLSTGDQLHAESPFISSGTTVPQTSVD PQVLTYLCLQIGKACRMRDVVGYFSIDLVTFIDPSTLEQQVWATGLNLAYSDQLALTQLTLYLTNGHLDCSLSTLEVPRFVPKERKKTKC MSALSMPMLATSRYAVMTTQLRHSNLSLVFHYVFLQICRAHGIGYDVEERQGTVFILYEHLKRHKLGMLTIGEDLQGVLMTFARHLFIIH -------------------------------------------------------------- >78229_78229_9_RPTOR-IQCH_RPTOR_chr17_78829347_ENST00000544334_IQCH_chr15_67692452_ENST00000335894_length(transcript)=3797nt_BP=1560nt TCAGACTTTTGCCTGAGTAAGGGTCTCCGCACTCTTTATCCATTTGGTTTTCGATTTCCCGTTTTTGTTTCTTATTTCACCAATTCTGGT ACACGCTAGTTTTTAAGGCTGGAGGTTCTCGAGCGCTTGCTGCCAAGGACTCCCCCACCCCCTCCCCCACTGATGGAGTCCGAAATGCTG CAATCGCCTCTTCTGGGCCTGGGGGAGGAAGATGAGGCTGATCTTACAGACTGGAACCTACCTTTGGCTTTTATGAAAAAGAGGCACTGT GAGAAAATTGAAGGCTCCAAATCCTTAGCTCAGAGCTGGAGGATGAAGGATCGGATGAAGACAGTCAGTGTTGCCTTAGTTTTGTGCCTG AATGTTGGTGTGGACCCTCCCGATGTGGTGAAGACCACGCCCTGTGCACGCTTGGAATGCTGGATCGATCCTCTGTCGATGGGTCCTCAG AAAGCTCTGGAAACCATCGGTGCAAATTTACAGAAGCAGTACGAGAACTGGCAGCCAAGGGCCCGGTACAAGCAGAGCCTTGACCCAACT GTGGATGAAGTCAAGAAGCTCTGCACGTCCTTACGTCGCAACGCCAAGGAGGAGCGAGTCCTCTTTCACTACAATGGCCACGGGGTGCCC CGGCCCACAGTCAACGGGGAGGTCTGGGTCTTCAACAAGAACTACACGCAGTACATCCCTCTGTCCATATATGACCTGCAGACGTGGATG GGCAGCCCGTCGATCTTCGTCTACGACTGCTCCAATGCTGGCTTGATCGTCAAGTCCTTCAAGCAGTTCGCACTACAGCGGGAGCAGGAG CTGGAGGTAGCTGCAATCAACCCAAATCACCCTCTTGCTCAGATGCCTTTGCCTCCGTCGATGAAAAACTGCATCCAGCTGGCAGCCTGC GAGGCCACCGAGCTGCTGCCCATGATCCCCGACCTCCCGGCTGACCTATTCACCTCCTGCCTCACCACCCCCATCAAGATCGCCCTGCGC TGGTTTTGCATGCAGAAATGTGTCAGTCTGGTGCCTGGCGTCACACTGGATTTGATAGAAAAGATCCCTGGCCGCCTGAACGACAGGAGG ACGCCCCTGGGTGAACTGAACTGGATCTTCACAGCCATCACAGACACCATCGCGTGGAACGTGCTCCCCCGGGATCTCTTCCAAAAGCTC TTCAGACAGGACTTGCTGGTGGCTAGTCTGTTTCGAAATTTTTTATTGGCGGAAAGGATTATGAGGTCGTATAACTGCACTCCCGTCAGC AGCCCGCGTCTGCCGCCCACGTACATGCACGCCATGTGGCAAGCCTGGGACCTGGCTGTTGACATCTGTCTGTCTCAGCTGCCGACGATC ATCGAGGAAGGCACTGCGTTTCGGCACAGCCCGTTCTTCGCCGAGCAGCTGACCGCATTCCAGGTGTGGCTCACCATGGGCGTGGAGAAC CGAAACCCACCCGAACAGCTGCCCATCGTCCTGCAGGTGCTGTTAAGCCAAGTGCACCGGCTGAGAGCATTGGACTTGCTTGGAAGATTT TTGGACCTGGGTCCCTGGGCAGTGAGCCTGATGATAGAGCAGCTGAGTCAGCTGATAACTGATCACCTGCAAATACAGCGTTGGCTCTTT AAAATGGACTCTGAGTTCCGAGGAAATGGGACTGCATTTTGTGATATTCCTTCCTACCTAAAGTGCTACAAATGGGTGCTAAAGGAGAGT AGCAGATATGGCCTTGAAGACTGGAGAAAGAAATGGGCACAAGAGCCAGCTTTGGTGAAGATCTCTGAGGAGCTGGCGGGCATTTTAGCA CAGCACGCACAGCCAGTCAATGAGAAACGGTTCCCGACGTGGAGGAAATTCCTCCAAACATTTCTCAGTCAAGGGGGTGTGATCGAAGCA TTCCCACCTGCAGACAATGTCACCAACCTCACAGTGGACATGCTGATAGAGCCCAACGGGAAAATCAGCGTGCTGTCGACAGGGGACCAG CTTCATGCTGAAAGCCCCTTCATCTCCTCTGGTACCACCGTGCCTCAGACCTCAGTGGATCCCCAAGTTCTCACTTATTTGTGCCTCCAA ATTGGAAAAGCCTGCAGAATGAGAGATGTGGTTGGTTACTTTTCGATAGATCTGGTGACTTTTATAGATCCAAGCACCTTGGAACAACAG GTGTGGGCAACCGGCCTTAACCTCGCATATAGTGACCAGCTGGCCCTGACTCAACTCACCTTATACCTGACAAACGGCCATCTGGATTGC AGTTTGAGCACCCTGGAAGTGCCCCGCTTTGTTCCAAAGGAAAGGAAGAAAACCAAATGCATGAGTGCGCTGTCAATGCCGATGCTGGCA ACCAGTCGCTATGCAGTGATGACCACCCAGCTAAGACACAGCAATCTCTCACTGGTTTTCCACTATGTTTTTCTCCAGATCTGTAGGGCC CATGGCATTGGCTATGATGTTGAGGAAAGGCAAGGAACTGTTTTTATATTATATGAGCACCTGAAGAGACACAAGTTGGGAATGTTAACA ATCGGCGAGGATCTCCAGGGGGTCCTCATGACCTTTGCTCGCCATCTCTTCATCATCCATCAAGAAATATCAGCACCTAATATGCAAGGC GAGACCAATTTTAAGACCACCATTGCTGATATTGAAACTATTCTAAGAGTAACAAAGGAAAACAAAATGAGATTTGAAGAGGAGCAACAG TCCAAAGATGATAAAAACCTCTCTAAACCCAAGAAATGATCCTGGAATACAGTACATAACAATTTGGATCCCAGTCTGGAATAAAAAGGG CAATTTTTTTTTCTGTTAGAAATAAAAGCCAGGGGAAATTGGTTTGCTTTGTGTGCTAGGAGGTGAATCAGAACAGATTATAATGAAATG CTCTTTTTAAAACATTGTTTATTAAGTGATCTTATTTTATTTATTAAACCAAAACTTATTTGTGTTTTCATTTGAGAGTGTTGAACAATC CCTTCTTCTTCTCAAACTCAGAAAAAAGTAATCTGATAAAAGAAGAAAGTTAAAAGTCTTACTGATATCACCTCCGCATTTACTTCCTCA TAGGCCTCAGGATTATGTAGCTTTTATTTTTTATGTTTTATAAAGTTTTCTCCTATTTCTAATAGTCCATCGATCTTCTGCATTTATAGG TTTGAATAAAGGCTTAAGAATTGCTATTTGTCAAAACACAAATGCCTTTTTTTCAAAGCTTCAAATTATATTGAAATTATATTTATATGA ATTTTTAAGTGACTATCATTCATCGTGTTTTTGTTATACCAAGCCACTATTGTCTGCTATTGTTGCCATTTTTCAAAAAGTAGGATAAGC CAGCATCTAGTTAACCAAAGCATCAGAATGTATCTAGGTGGCAGTATCTGCTCTTAGTTTAAGATGGAGTGTAGCTCGAGCTCTGTAGCT TGAATAAACATTTGTATTCTCTAGTTCTCCATTTAATACAGCAGTAGGATTTTTTCAAGTTTAGTTCAACATTATACTACCTTTAAAAAG GCAGACTGTTAAGATTGTAGTAGTGCTGACTCTAACTTTCAGCATTCACTTCATAATTGTCCAAAAATATTTCCACATCAGTGAGCTTTA CTGAAGGGTGAAATAAAAGCAAATTACAACACCAAAACCATTATTGTTTTAAAGAATGACCTTTATGTCTATAAAAATATTTTAGTGTAT TGGGGAAAGGAATAGGATTTTTACCTGTGGAATTTCAATAATTTGTTAACTGTGATTCAGCCACAGGCTAAGAGTTTCTGTAATAAAATT >78229_78229_9_RPTOR-IQCH_RPTOR_chr17_78829347_ENST00000544334_IQCH_chr15_67692452_ENST00000335894_length(amino acids)=876AA_BP=482 MEVLERLLPRTPPPPPPLMESEMLQSPLLGLGEEDEADLTDWNLPLAFMKKRHCEKIEGSKSLAQSWRMKDRMKTVSVALVLCLNVGVDP PDVVKTTPCARLECWIDPLSMGPQKALETIGANLQKQYENWQPRARYKQSLDPTVDEVKKLCTSLRRNAKEERVLFHYNGHGVPRPTVNG EVWVFNKNYTQYIPLSIYDLQTWMGSPSIFVYDCSNAGLIVKSFKQFALQREQELEVAAINPNHPLAQMPLPPSMKNCIQLAACEATELL PMIPDLPADLFTSCLTTPIKIALRWFCMQKCVSLVPGVTLDLIEKIPGRLNDRRTPLGELNWIFTAITDTIAWNVLPRDLFQKLFRQDLL VASLFRNFLLAERIMRSYNCTPVSSPRLPPTYMHAMWQAWDLAVDICLSQLPTIIEEGTAFRHSPFFAEQLTAFQVWLTMGVENRNPPEQ LPIVLQVLLSQVHRLRALDLLGRFLDLGPWAVSLMIEQLSQLITDHLQIQRWLFKMDSEFRGNGTAFCDIPSYLKCYKWVLKESSRYGLE DWRKKWAQEPALVKISEELAGILAQHAQPVNEKRFPTWRKFLQTFLSQGGVIEAFPPADNVTNLTVDMLIEPNGKISVLSTGDQLHAESP FISSGTTVPQTSVDPQVLTYLCLQIGKACRMRDVVGYFSIDLVTFIDPSTLEQQVWATGLNLAYSDQLALTQLTLYLTNGHLDCSLSTLE VPRFVPKERKKTKCMSALSMPMLATSRYAVMTTQLRHSNLSLVFHYVFLQICRAHGIGYDVEERQGTVFILYEHLKRHKLGMLTIGEDLQ -------------------------------------------------------------- >78229_78229_10_RPTOR-IQCH_RPTOR_chr17_78829347_ENST00000544334_IQCH_chr15_67692452_ENST00000358767_length(transcript)=3734nt_BP=1560nt TCAGACTTTTGCCTGAGTAAGGGTCTCCGCACTCTTTATCCATTTGGTTTTCGATTTCCCGTTTTTGTTTCTTATTTCACCAATTCTGGT ACACGCTAGTTTTTAAGGCTGGAGGTTCTCGAGCGCTTGCTGCCAAGGACTCCCCCACCCCCTCCCCCACTGATGGAGTCCGAAATGCTG CAATCGCCTCTTCTGGGCCTGGGGGAGGAAGATGAGGCTGATCTTACAGACTGGAACCTACCTTTGGCTTTTATGAAAAAGAGGCACTGT GAGAAAATTGAAGGCTCCAAATCCTTAGCTCAGAGCTGGAGGATGAAGGATCGGATGAAGACAGTCAGTGTTGCCTTAGTTTTGTGCCTG AATGTTGGTGTGGACCCTCCCGATGTGGTGAAGACCACGCCCTGTGCACGCTTGGAATGCTGGATCGATCCTCTGTCGATGGGTCCTCAG AAAGCTCTGGAAACCATCGGTGCAAATTTACAGAAGCAGTACGAGAACTGGCAGCCAAGGGCCCGGTACAAGCAGAGCCTTGACCCAACT GTGGATGAAGTCAAGAAGCTCTGCACGTCCTTACGTCGCAACGCCAAGGAGGAGCGAGTCCTCTTTCACTACAATGGCCACGGGGTGCCC CGGCCCACAGTCAACGGGGAGGTCTGGGTCTTCAACAAGAACTACACGCAGTACATCCCTCTGTCCATATATGACCTGCAGACGTGGATG GGCAGCCCGTCGATCTTCGTCTACGACTGCTCCAATGCTGGCTTGATCGTCAAGTCCTTCAAGCAGTTCGCACTACAGCGGGAGCAGGAG CTGGAGGTAGCTGCAATCAACCCAAATCACCCTCTTGCTCAGATGCCTTTGCCTCCGTCGATGAAAAACTGCATCCAGCTGGCAGCCTGC GAGGCCACCGAGCTGCTGCCCATGATCCCCGACCTCCCGGCTGACCTATTCACCTCCTGCCTCACCACCCCCATCAAGATCGCCCTGCGC TGGTTTTGCATGCAGAAATGTGTCAGTCTGGTGCCTGGCGTCACACTGGATTTGATAGAAAAGATCCCTGGCCGCCTGAACGACAGGAGG ACGCCCCTGGGTGAACTGAACTGGATCTTCACAGCCATCACAGACACCATCGCGTGGAACGTGCTCCCCCGGGATCTCTTCCAAAAGCTC TTCAGACAGGACTTGCTGGTGGCTAGTCTGTTTCGAAATTTTTTATTGGCGGAAAGGATTATGAGGTCGTATAACTGCACTCCCGTCAGC AGCCCGCGTCTGCCGCCCACGTACATGCACGCCATGTGGCAAGCCTGGGACCTGGCTGTTGACATCTGTCTGTCTCAGCTGCCGACGATC ATCGAGGAAGGCACTGCGTTTCGGCACAGCCCGTTCTTCGCCGAGCAGCTGACCGCATTCCAGGTGTGGCTCACCATGGGCGTGGAGAAC CGAAACCCACCCGAACAGCTGCCCATCGTCCTGCAGGTGCTGTTAAGCCAAGTGCACCGGCTGAGAGCATTGGACTTGCTTGGAAGATTT TTGGACCTGGGTCCCTGGGCAGTGAGCCTGATGATAGAGCAGCTGAGTCAGCTGATAACTGATCACCTGCAAATACAGCGTTGGCTCTTT AAAATGGACTCTGAGTTCCGAGGAAATGGGACTGCATTTTGTGATATTCCTTCCTACCTAAAGTGCTACAAATGGGTGCTAAAGGAGAGT AGCAGATATGGCCTTGAAGACTGGAGAAAGAAATGGGCACAAGAGCCAGCTTTGGTGAAGATCTCTGAGGAGCTGGCGGGCATTTTAGCA CAGCACGCACAGCCAGTCAATGAGAAACGGTTCCCGACGTGGAGGAAATTCCTCCAAACATTTCTCAGTCAAGGGGGTGTGATCGAAGCA TTCCCACCTGCAGACAATGTCACCAACCTCACAGTGGACATGCTGATAGAGCCCAACGGGAAAATCAGCGTGCTGTCGACAGGGGACCAG CTTCATGCTGAAAGCCCCTTCATCTCCTCTGGTACCACCGTGCCTCAGACCTCAGTGGATCCCCAAGTTCTCACTTATTTGTGCCTCCAA ATTGGAAAAGCCTGCAGAATGAGAGATGTGGTTGGTTACTTTTCGATAGATCTGGTGACTTTTATAGATCCAAGCACCTTGGAACAACAG GTGTGGGCAACCGGCCTTAACCTCGCATATAGTGACCAGCTGGCCCTGACTCAACTCACCTTATACCTGACAAACGGCCATCTGGATTGC AGTTTGAGCACCCTGGAAGTGCCCCGCTTTGTTCCAAAGGAAAGGAAGAAAACCAAATGCATGAGTGCGCTGTCAATGCCGATGCTGGCA ACCAGTCGCTATGCAGTGATGACCACCCAGCTAAGACACAGCAATCTCTCACTGGTTTTCCACTATGTTTTTCTCCAGATCTGTAGGGCC CATGGCATTGGCTATGATGTTGAGAACAATCGGCGAGGATCTCCAGGGGGTCCTCATGACCTTTGCTCGCCATCTCTTCATCATCCATCA AGAAATATCAGCACCTAATATGCAAGGCGAGACCAATTTTAAGACCACCATTGCTGATATTGAAACTATTCTAAGAGTAACAAAGGAAAA CAAAATGAGATTTGAAGAGGAGCAACAGTCCAAAGATGATAAAAACCTCTCTAAACCCAAGAAATGATCCTGGAATACAGTACATAACAA TTTGGATCCCAGTCTGGAATAAAAAGGGCAATTTTTTTTTCTGTTAGAAATAAAAGCCAGGGGAAATTGGTTTGCTTTGTGTGCTAGGAG GTGAATCAGAACAGATTATAATGAAATGCTCTTTTTAAAACATTGTTTATTAAGTGATCTTATTTTATTTATTAAACCAAAACTTATTTG TGTTTTCATTTGAGAGTGTTGAACAATCCCTTCTTCTTCTCAAACTCAGAAAAAAGTAATCTGATAAAAGAAGAAAGTTAAAAGTCTTAC TGATATCACCTCCGCATTTACTTCCTCATAGGCCTCAGGATTATGTAGCTTTTATTTTTTATGTTTTATAAAGTTTTCTCCTATTTCTAA TAGTCCATCGATCTTCTGCATTTATAGGTTTGAATAAAGGCTTAAGAATTGCTATTTGTCAAAACACAAATGCCTTTTTTTCAAAGCTTC AAATTATATTGAAATTATATTTATATGAATTTTTAAGTGACTATCATTCATCGTGTTTTTGTTATACCAAGCCACTATTGTCTGCTATTG TTGCCATTTTTCAAAAAGTAGGATAAGCCAGCATCTAGTTAACCAAAGCATCAGAATGTATCTAGGTGGCAGTATCTGCTCTTAGTTTAA GATGGAGTGTAGCTCGAGCTCTGTAGCTTGAATAAACATTTGTATTCTCTAGTTCTCCATTTAATACAGCAGTAGGATTTTTTCAAGTTT AGTTCAACATTATACTACCTTTAAAAAGGCAGACTGTTAAGATTGTAGTAGTGCTGACTCTAACTTTCAGCATTCACTTCATAATTGTCC AAAAATATTTCCACATCAGTGAGCTTTACTGAAGGGTGAAATAAAAGCAAATTACAACACCAAAACCATTATTGTTTTAAAGAATGACCT TTATGTCTATAAAAATATTTTAGTGTATTGGGGAAAGGAATAGGATTTTTACCTGTGGAATTTCAATAATTTGTTAACTGTGATTCAGCC >78229_78229_10_RPTOR-IQCH_RPTOR_chr17_78829347_ENST00000544334_IQCH_chr15_67692452_ENST00000358767_length(amino acids)=809AA_BP=482 MEVLERLLPRTPPPPPPLMESEMLQSPLLGLGEEDEADLTDWNLPLAFMKKRHCEKIEGSKSLAQSWRMKDRMKTVSVALVLCLNVGVDP PDVVKTTPCARLECWIDPLSMGPQKALETIGANLQKQYENWQPRARYKQSLDPTVDEVKKLCTSLRRNAKEERVLFHYNGHGVPRPTVNG EVWVFNKNYTQYIPLSIYDLQTWMGSPSIFVYDCSNAGLIVKSFKQFALQREQELEVAAINPNHPLAQMPLPPSMKNCIQLAACEATELL PMIPDLPADLFTSCLTTPIKIALRWFCMQKCVSLVPGVTLDLIEKIPGRLNDRRTPLGELNWIFTAITDTIAWNVLPRDLFQKLFRQDLL VASLFRNFLLAERIMRSYNCTPVSSPRLPPTYMHAMWQAWDLAVDICLSQLPTIIEEGTAFRHSPFFAEQLTAFQVWLTMGVENRNPPEQ LPIVLQVLLSQVHRLRALDLLGRFLDLGPWAVSLMIEQLSQLITDHLQIQRWLFKMDSEFRGNGTAFCDIPSYLKCYKWVLKESSRYGLE DWRKKWAQEPALVKISEELAGILAQHAQPVNEKRFPTWRKFLQTFLSQGGVIEAFPPADNVTNLTVDMLIEPNGKISVLSTGDQLHAESP FISSGTTVPQTSVDPQVLTYLCLQIGKACRMRDVVGYFSIDLVTFIDPSTLEQQVWATGLNLAYSDQLALTQLTLYLTNGHLDCSLSTLE -------------------------------------------------------------- >78229_78229_11_RPTOR-IQCH_RPTOR_chr17_78829347_ENST00000544334_IQCH_chr15_67692452_ENST00000360277_length(transcript)=3734nt_BP=1560nt TCAGACTTTTGCCTGAGTAAGGGTCTCCGCACTCTTTATCCATTTGGTTTTCGATTTCCCGTTTTTGTTTCTTATTTCACCAATTCTGGT ACACGCTAGTTTTTAAGGCTGGAGGTTCTCGAGCGCTTGCTGCCAAGGACTCCCCCACCCCCTCCCCCACTGATGGAGTCCGAAATGCTG CAATCGCCTCTTCTGGGCCTGGGGGAGGAAGATGAGGCTGATCTTACAGACTGGAACCTACCTTTGGCTTTTATGAAAAAGAGGCACTGT GAGAAAATTGAAGGCTCCAAATCCTTAGCTCAGAGCTGGAGGATGAAGGATCGGATGAAGACAGTCAGTGTTGCCTTAGTTTTGTGCCTG AATGTTGGTGTGGACCCTCCCGATGTGGTGAAGACCACGCCCTGTGCACGCTTGGAATGCTGGATCGATCCTCTGTCGATGGGTCCTCAG AAAGCTCTGGAAACCATCGGTGCAAATTTACAGAAGCAGTACGAGAACTGGCAGCCAAGGGCCCGGTACAAGCAGAGCCTTGACCCAACT GTGGATGAAGTCAAGAAGCTCTGCACGTCCTTACGTCGCAACGCCAAGGAGGAGCGAGTCCTCTTTCACTACAATGGCCACGGGGTGCCC CGGCCCACAGTCAACGGGGAGGTCTGGGTCTTCAACAAGAACTACACGCAGTACATCCCTCTGTCCATATATGACCTGCAGACGTGGATG GGCAGCCCGTCGATCTTCGTCTACGACTGCTCCAATGCTGGCTTGATCGTCAAGTCCTTCAAGCAGTTCGCACTACAGCGGGAGCAGGAG CTGGAGGTAGCTGCAATCAACCCAAATCACCCTCTTGCTCAGATGCCTTTGCCTCCGTCGATGAAAAACTGCATCCAGCTGGCAGCCTGC GAGGCCACCGAGCTGCTGCCCATGATCCCCGACCTCCCGGCTGACCTATTCACCTCCTGCCTCACCACCCCCATCAAGATCGCCCTGCGC TGGTTTTGCATGCAGAAATGTGTCAGTCTGGTGCCTGGCGTCACACTGGATTTGATAGAAAAGATCCCTGGCCGCCTGAACGACAGGAGG ACGCCCCTGGGTGAACTGAACTGGATCTTCACAGCCATCACAGACACCATCGCGTGGAACGTGCTCCCCCGGGATCTCTTCCAAAAGCTC TTCAGACAGGACTTGCTGGTGGCTAGTCTGTTTCGAAATTTTTTATTGGCGGAAAGGATTATGAGGTCGTATAACTGCACTCCCGTCAGC AGCCCGCGTCTGCCGCCCACGTACATGCACGCCATGTGGCAAGCCTGGGACCTGGCTGTTGACATCTGTCTGTCTCAGCTGCCGACGATC ATCGAGGAAGGCACTGCGTTTCGGCACAGCCCGTTCTTCGCCGAGCAGCTGACCGCATTCCAGGTGTGGCTCACCATGGGCGTGGAGAAC CGAAACCCACCCGAACAGCTGCCCATCGTCCTGCAGGTGCTGTTAAGCCAAGTGCACCGGCTGAGAGCATTGGACTTGCTTGGAAGATTT TTGGACCTGGGTCCCTGGGCAGTGAGCCTGATGATAGAGCAGCTGAGTCAGCTGATAACTGATCACCTGCAAATACAGCGTTGGCTCTTT AAAATGGACTCTGAGTTCCGAGGAAATGGGACTGCATTTTGTGATATTCCTTCCTACCTAAAGTGCTACAAATGGGTGCTAAAGGAGAGT AGCAGATATGGCCTTGAAGACTGGAGAAAGAAATGGGCACAAGAGCCAGCTTTGGTGAAGATCTCTGAGGAGCTGGCGGGCATTTTAGCA CAGCACGCACAGCCAGTCAATGAGAAACGGTTCCCGACGTGGAGGAAATTCCTCCAAACATTTCTCAGTCAAGGGGGTGTGATCGAAGCA TTCCCACCTGCAGACAATGTCACCAACCTCACAGTGGACATGCTGATAGAGCCCAACGGGAAAATCAGCGTGCTGTCGACAGGGGACCAG CTTCATGCTGAAAGCCCCTTCATCTCCTCTGGTACCACCGTGCCTCAGACCTCAGTGGATCCCCAAGTTCTCACTTATTTGTGCCTCCAA ATTGGAAAAGCCTGCAGAATGAGAGATGTGGTTGGTTACTTTTCGATAGATCTGGTGACTTTTATAGATCCAAGCACCTTGGAACAACAG GTGTGGGCAACCGGCCTTAACCTCGCATATAGTGACCAGCTGGCCCTGACTCAACTCACCTTATACCTGACAAACGGCCATCTGGATTGC AGTTTGAGCACCCTGGAAGTGCCCCGCTTTGTTCCAAAGGAAAGGAAGAAAACCAAATGCATGAGTGCGCTGTCAATGCCGATGCTGGCA ACCAGTCGCTATGCAGTGATGACCACCCAGCTAAGACACAGCAATCTCTCACTGGTTTTCCACTATGTTTTTCTCCAGATCTGTAGGGCC CATGGCATTGGCTATGATGTTGAGAACAATCGGCGAGGATCTCCAGGGGGTCCTCATGACCTTTGCTCGCCATCTCTTCATCATCCATCA AGAAATATCAGCACCTAATATGCAAGGCGAGACCAATTTTAAGACCACCATTGCTGATATTGAAACTATTCTAAGAGTAACAAAGGAAAA CAAAATGAGATTTGAAGAGGAGCAACAGTCCAAAGATGATAAAAACCTCTCTAAACCCAAGAAATGATCCTGGAATACAGTACATAACAA TTTGGATCCCAGTCTGGAATAAAAAGGGCAATTTTTTTTTCTGTTAGAAATAAAAGCCAGGGGAAATTGGTTTGCTTTGTGTGCTAGGAG GTGAATCAGAACAGATTATAATGAAATGCTCTTTTTAAAACATTGTTTATTAAGTGATCTTATTTTATTTATTAAACCAAAACTTATTTG TGTTTTCATTTGAGAGTGTTGAACAATCCCTTCTTCTTCTCAAACTCAGAAAAAAGTAATCTGATAAAAGAAGAAAGTTAAAAGTCTTAC TGATATCACCTCCGCATTTACTTCCTCATAGGCCTCAGGATTATGTAGCTTTTATTTTTTATGTTTTATAAAGTTTTCTCCTATTTCTAA TAGTCCATCGATCTTCTGCATTTATAGGTTTGAATAAAGGCTTAAGAATTGCTATTTGTCAAAACACAAATGCCTTTTTTTCAAAGCTTC AAATTATATTGAAATTATATTTATATGAATTTTTAAGTGACTATCATTCATCGTGTTTTTGTTATACCAAGCCACTATTGTCTGCTATTG TTGCCATTTTTCAAAAAGTAGGATAAGCCAGCATCTAGTTAACCAAAGCATCAGAATGTATCTAGGTGGCAGTATCTGCTCTTAGTTTAA GATGGAGTGTAGCTCGAGCTCTGTAGCTTGAATAAACATTTGTATTCTCTAGTTCTCCATTTAATACAGCAGTAGGATTTTTTCAAGTTT AGTTCAACATTATACTACCTTTAAAAAGGCAGACTGTTAAGATTGTAGTAGTGCTGACTCTAACTTTCAGCATTCACTTCATAATTGTCC AAAAATATTTCCACATCAGTGAGCTTTACTGAAGGGTGAAATAAAAGCAAATTACAACACCAAAACCATTATTGTTTTAAAGAATGACCT TTATGTCTATAAAAATATTTTAGTGTATTGGGGAAAGGAATAGGATTTTTACCTGTGGAATTTCAATAATTTGTTAACTGTGATTCAGCC >78229_78229_11_RPTOR-IQCH_RPTOR_chr17_78829347_ENST00000544334_IQCH_chr15_67692452_ENST00000360277_length(amino acids)=809AA_BP=482 MEVLERLLPRTPPPPPPLMESEMLQSPLLGLGEEDEADLTDWNLPLAFMKKRHCEKIEGSKSLAQSWRMKDRMKTVSVALVLCLNVGVDP PDVVKTTPCARLECWIDPLSMGPQKALETIGANLQKQYENWQPRARYKQSLDPTVDEVKKLCTSLRRNAKEERVLFHYNGHGVPRPTVNG EVWVFNKNYTQYIPLSIYDLQTWMGSPSIFVYDCSNAGLIVKSFKQFALQREQELEVAAINPNHPLAQMPLPPSMKNCIQLAACEATELL PMIPDLPADLFTSCLTTPIKIALRWFCMQKCVSLVPGVTLDLIEKIPGRLNDRRTPLGELNWIFTAITDTIAWNVLPRDLFQKLFRQDLL VASLFRNFLLAERIMRSYNCTPVSSPRLPPTYMHAMWQAWDLAVDICLSQLPTIIEEGTAFRHSPFFAEQLTAFQVWLTMGVENRNPPEQ LPIVLQVLLSQVHRLRALDLLGRFLDLGPWAVSLMIEQLSQLITDHLQIQRWLFKMDSEFRGNGTAFCDIPSYLKCYKWVLKESSRYGLE DWRKKWAQEPALVKISEELAGILAQHAQPVNEKRFPTWRKFLQTFLSQGGVIEAFPPADNVTNLTVDMLIEPNGKISVLSTGDQLHAESP FISSGTTVPQTSVDPQVLTYLCLQIGKACRMRDVVGYFSIDLVTFIDPSTLEQQVWATGLNLAYSDQLALTQLTLYLTNGHLDCSLSTLE -------------------------------------------------------------- >78229_78229_12_RPTOR-IQCH_RPTOR_chr17_78829347_ENST00000544334_IQCH_chr15_67692452_ENST00000546225_length(transcript)=3796nt_BP=1560nt TCAGACTTTTGCCTGAGTAAGGGTCTCCGCACTCTTTATCCATTTGGTTTTCGATTTCCCGTTTTTGTTTCTTATTTCACCAATTCTGGT ACACGCTAGTTTTTAAGGCTGGAGGTTCTCGAGCGCTTGCTGCCAAGGACTCCCCCACCCCCTCCCCCACTGATGGAGTCCGAAATGCTG CAATCGCCTCTTCTGGGCCTGGGGGAGGAAGATGAGGCTGATCTTACAGACTGGAACCTACCTTTGGCTTTTATGAAAAAGAGGCACTGT GAGAAAATTGAAGGCTCCAAATCCTTAGCTCAGAGCTGGAGGATGAAGGATCGGATGAAGACAGTCAGTGTTGCCTTAGTTTTGTGCCTG AATGTTGGTGTGGACCCTCCCGATGTGGTGAAGACCACGCCCTGTGCACGCTTGGAATGCTGGATCGATCCTCTGTCGATGGGTCCTCAG AAAGCTCTGGAAACCATCGGTGCAAATTTACAGAAGCAGTACGAGAACTGGCAGCCAAGGGCCCGGTACAAGCAGAGCCTTGACCCAACT GTGGATGAAGTCAAGAAGCTCTGCACGTCCTTACGTCGCAACGCCAAGGAGGAGCGAGTCCTCTTTCACTACAATGGCCACGGGGTGCCC CGGCCCACAGTCAACGGGGAGGTCTGGGTCTTCAACAAGAACTACACGCAGTACATCCCTCTGTCCATATATGACCTGCAGACGTGGATG GGCAGCCCGTCGATCTTCGTCTACGACTGCTCCAATGCTGGCTTGATCGTCAAGTCCTTCAAGCAGTTCGCACTACAGCGGGAGCAGGAG CTGGAGGTAGCTGCAATCAACCCAAATCACCCTCTTGCTCAGATGCCTTTGCCTCCGTCGATGAAAAACTGCATCCAGCTGGCAGCCTGC GAGGCCACCGAGCTGCTGCCCATGATCCCCGACCTCCCGGCTGACCTATTCACCTCCTGCCTCACCACCCCCATCAAGATCGCCCTGCGC TGGTTTTGCATGCAGAAATGTGTCAGTCTGGTGCCTGGCGTCACACTGGATTTGATAGAAAAGATCCCTGGCCGCCTGAACGACAGGAGG ACGCCCCTGGGTGAACTGAACTGGATCTTCACAGCCATCACAGACACCATCGCGTGGAACGTGCTCCCCCGGGATCTCTTCCAAAAGCTC TTCAGACAGGACTTGCTGGTGGCTAGTCTGTTTCGAAATTTTTTATTGGCGGAAAGGATTATGAGGTCGTATAACTGCACTCCCGTCAGC AGCCCGCGTCTGCCGCCCACGTACATGCACGCCATGTGGCAAGCCTGGGACCTGGCTGTTGACATCTGTCTGTCTCAGCTGCCGACGATC ATCGAGGAAGGCACTGCGTTTCGGCACAGCCCGTTCTTCGCCGAGCAGCTGACCGCATTCCAGGTGTGGCTCACCATGGGCGTGGAGAAC CGAAACCCACCCGAACAGCTGCCCATCGTCCTGCAGGTGCTGTTAAGCCAAGTGCACCGGCTGAGAGCATTGGACTTGCTTGGAAGATTT TTGGACCTGGGTCCCTGGGCAGTGAGCCTGATGATAGAGCAGCTGAGTCAGCTGATAACTGATCACCTGCAAATACAGCGTTGGCTCTTT AAAATGGACTCTGAGTTCCGAGGAAATGGGACTGCATTTTGTGATATTCCTTCCTACCTAAAGTGCTACAAATGGGTGCTAAAGGAGAGT AGCAGATATGGCCTTGAAGACTGGAGAAAGAAATGGGCACAAGAGCCAGCTTTGGTGAAGATCTCTGAGGAGCTGGCGGGCATTTTAGCA CAGCACGCACAGCCAGTCAATGAGAAACGGTTCCCGACGTGGAGGAAATTCCTCCAAACATTTCTCAGTCAAGGGGGTGTGATCGAAGCA TTCCCACCTGCAGACAATGTCACCAACCTCACAGTGGACATGCTGATAGAGCCCAACGGGAAAATCAGCGTGCTGTCGACAGGGGACCAG CTTCATGCTGAAAGCCCCTTCATCTCCTCTGGTACCACCGTGCCTCAGACCTCAGTGGATCCCCAAGTTCTCACTTATTTGTGCCTCCAA ATTGGAAAAGCCTGCAGAATGAGAGATGTGGTTGGTTACTTTTCGATAGATCTGGTGACTTTTATAGATCCAAGCACCTTGGAACAACAG GTGTGGGCAACCGGCCTTAACCTCGCATATAGTGACCAGCTGGCCCTGACTCAACTCACCTTATACCTGACAAACGGCCATCTGGATTGC AGTTTGAGCACCCTGGAAGTGCCCCGCTTTGTTCCAAAGGAAAGGAAGAAAACCAAATGCATGAGTGCGCTGTCAATGCCGATGCTGGCA ACCAGTCGCTATGCAGTGATGACCACCCAGCTAAGACACAGCAATCTCTCACTGGTTTTCCACTATGTTTTTCTCCAGATCTGTAGGGCC CATGGCATTGGCTATGATGTTGAGGAAAGGCAAGGAACTGTTTTTATATTATATGAGCACCTGAAGAGACACAAGTTGGGAATGTTAACA ATCGGCGAGGATCTCCAGGGGGTCCTCATGACCTTTGCTCGCCATCTCTTCATCATCCATCAAGAAATATCAGCACCTAATATGCAAGGC GAGACCAATTTTAAGACCACCATTGCTGATATTGAAACTATTCTAAGAGTAACAAAGGAAAACAAAATGAGATTTGAAGAGGAGCAACAG TCCAAAGATGATAAAAACCTCTCTAAACCCAAGAAATGATCCTGGAATACAGTACATAACAATTTGGATCCCAGTCTGGAATAAAAAGGG CAATTTTTTTTTCTGTTAGAAATAAAAGCCAGGGGAAATTGGTTTGCTTTGTGTGCTAGGAGGTGAATCAGAACAGATTATAATGAAATG CTCTTTTTAAAACATTGTTTATTAAGTGATCTTATTTTATTTATTAAACCAAAACTTATTTGTGTTTTCATTTGAGAGTGTTGAACAATC CCTTCTTCTTCTCAAACTCAGAAAAAAGTAATCTGATAAAAGAAGAAAGTTAAAAGTCTTACTGATATCACCTCCGCATTTACTTCCTCA TAGGCCTCAGGATTATGTAGCTTTTATTTTTTATGTTTTATAAAGTTTTCTCCTATTTCTAATAGTCCATCGATCTTCTGCATTTATAGG TTTGAATAAAGGCTTAAGAATTGCTATTTGTCAAAACACAAATGCCTTTTTTTCAAAGCTTCAAATTATATTGAAATTATATTTATATGA ATTTTTAAGTGACTATCATTCATCGTGTTTTTGTTATACCAAGCCACTATTGTCTGCTATTGTTGCCATTTTTCAAAAAGTAGGATAAGC CAGCATCTAGTTAACCAAAGCATCAGAATGTATCTAGGTGGCAGTATCTGCTCTTAGTTTAAGATGGAGTGTAGCTCGAGCTCTGTAGCT TGAATAAACATTTGTATTCTCTAGTTCTCCATTTAATACAGCAGTAGGATTTTTTCAAGTTTAGTTCAACATTATACTACCTTTAAAAAG GCAGACTGTTAAGATTGTAGTAGTGCTGACTCTAACTTTCAGCATTCACTTCATAATTGTCCAAAAATATTTCCACATCAGTGAGCTTTA CTGAAGGGTGAAATAAAAGCAAATTACAACACCAAAACCATTATTGTTTTAAAGAATGACCTTTATGTCTATAAAAATATTTTAGTGTAT TGGGGAAAGGAATAGGATTTTTACCTGTGGAATTTCAATAATTTGTTAACTGTGATTCAGCCACAGGCTAAGAGTTTCTGTAATAAAATT >78229_78229_12_RPTOR-IQCH_RPTOR_chr17_78829347_ENST00000544334_IQCH_chr15_67692452_ENST00000546225_length(amino acids)=876AA_BP=482 MEVLERLLPRTPPPPPPLMESEMLQSPLLGLGEEDEADLTDWNLPLAFMKKRHCEKIEGSKSLAQSWRMKDRMKTVSVALVLCLNVGVDP PDVVKTTPCARLECWIDPLSMGPQKALETIGANLQKQYENWQPRARYKQSLDPTVDEVKKLCTSLRRNAKEERVLFHYNGHGVPRPTVNG EVWVFNKNYTQYIPLSIYDLQTWMGSPSIFVYDCSNAGLIVKSFKQFALQREQELEVAAINPNHPLAQMPLPPSMKNCIQLAACEATELL PMIPDLPADLFTSCLTTPIKIALRWFCMQKCVSLVPGVTLDLIEKIPGRLNDRRTPLGELNWIFTAITDTIAWNVLPRDLFQKLFRQDLL VASLFRNFLLAERIMRSYNCTPVSSPRLPPTYMHAMWQAWDLAVDICLSQLPTIIEEGTAFRHSPFFAEQLTAFQVWLTMGVENRNPPEQ LPIVLQVLLSQVHRLRALDLLGRFLDLGPWAVSLMIEQLSQLITDHLQIQRWLFKMDSEFRGNGTAFCDIPSYLKCYKWVLKESSRYGLE DWRKKWAQEPALVKISEELAGILAQHAQPVNEKRFPTWRKFLQTFLSQGGVIEAFPPADNVTNLTVDMLIEPNGKISVLSTGDQLHAESP FISSGTTVPQTSVDPQVLTYLCLQIGKACRMRDVVGYFSIDLVTFIDPSTLEQQVWATGLNLAYSDQLALTQLTLYLTNGHLDCSLSTLE VPRFVPKERKKTKCMSALSMPMLATSRYAVMTTQLRHSNLSLVFHYVFLQICRAHGIGYDVEERQGTVFILYEHLKRHKLGMLTIGEDLQ -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for RPTOR-IQCH |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for RPTOR-IQCH |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for RPTOR-IQCH |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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