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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ATP2A2-ARPC3 (FusionGDB2 ID:7825)

Fusion Gene Summary for ATP2A2-ARPC3

check button Fusion gene summary
Fusion gene informationFusion gene name: ATP2A2-ARPC3
Fusion gene ID: 7825
HgeneTgene
Gene symbol

ATP2A2

ARPC3

Gene ID

488

10094

Gene nameATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2actin related protein 2/3 complex subunit 3
SynonymsATP2B|DAR|DD|SERCA2ARC21|p21-Arc
Cytomap

12q24.11

12q24.11

Type of geneprotein-codingprotein-coding
Descriptionsarcoplasmic/endoplasmic reticulum calcium ATPase 2ATPase Ca++ transporting cardiac muscle slow twitch 2ATPase, Ca++ dependent, slow-twitch, cardiac muscle-2SR Ca(2+)-ATPase 2calcium pump 2calcium-transporting ATPase sarcoplasmic reticulum type, slowactin-related protein 2/3 complex subunit 3ARP2/3 protein complex subunit p21actin related protein 2/3 complex, subunit 3, 21kDaarp2/3 complex 21 kDa subunit
Modification date2020031320200313
UniProtAcc

P16615

O15145

Ensembl transtripts involved in fusion geneENST00000550248, ENST00000308664, 
ENST00000395494, ENST00000539276, 
ENST00000552636, 		ENST00000228825, 
ENST00000471641, 
Fusion gene scores* DoF score17 X 22 X 11=41146 X 4 X 4=96
# samples 277
** MAII scorelog2(27/4114*10)=-3.9295104814741
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(7/96*10)=-0.45567948377619
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ATP2A2 [Title/Abstract] AND ARPC3 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointATP2A2(110734542)-ARPC3(110878193), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneATP2A2

GO:0032469

endoplasmic reticulum calcium ion homeostasis

16402920

HgeneATP2A2

GO:0032470

positive regulation of endoplasmic reticulum calcium ion concentration

16402920

HgeneATP2A2

GO:0070588

calcium ion transmembrane transport

16402920

HgeneATP2A2

GO:1903515

calcium ion transport from cytosol to endoplasmic reticulum

16402920

TgeneARPC3

GO:0034314

Arp2/3 complex-mediated actin nucleation

11741539


check buttonFusion gene breakpoints across ATP2A2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across ARPC3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-BR-8366-01AATP2A2chr12

110734542

+ARPC3chr12

110878193

-


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Fusion Gene ORF analysis for ATP2A2-ARPC3

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000550248ENST00000228825ATP2A2chr12

110734542

+ARPC3chr12

110878193

-
3UTR-intronENST00000550248ENST00000471641ATP2A2chr12

110734542

+ARPC3chr12

110878193

-
5CDS-intronENST00000308664ENST00000471641ATP2A2chr12

110734542

+ARPC3chr12

110878193

-
5CDS-intronENST00000395494ENST00000471641ATP2A2chr12

110734542

+ARPC3chr12

110878193

-
5CDS-intronENST00000539276ENST00000471641ATP2A2chr12

110734542

+ARPC3chr12

110878193

-
In-frameENST00000308664ENST00000228825ATP2A2chr12

110734542

+ARPC3chr12

110878193

-
In-frameENST00000395494ENST00000228825ATP2A2chr12

110734542

+ARPC3chr12

110878193

-
In-frameENST00000539276ENST00000228825ATP2A2chr12

110734542

+ARPC3chr12

110878193

-
intron-3CDSENST00000552636ENST00000228825ATP2A2chr12

110734542

+ARPC3chr12

110878193

-
intron-intronENST00000552636ENST00000471641ATP2A2chr12

110734542

+ARPC3chr12

110878193

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000308664ATP2A2chr12110734542+ENST00000228825ARPC3chr12110878193-189811373291567412
ENST00000395494ATP2A2chr12110734542+ENST00000228825ARPC3chr12110878193-178710262181456412
ENST00000539276ATP2A2chr12110734542+ENST00000228825ARPC3chr12110878193-13335721091002297

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000308664ENST00000228825ATP2A2chr12110734542+ARPC3chr12110878193-0.0020407490.99795926
ENST00000395494ENST00000228825ATP2A2chr12110734542+ARPC3chr12110878193-0.0020385740.9979614
ENST00000539276ENST00000228825ATP2A2chr12110734542+ARPC3chr12110878193-0.0009895830.99901044

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Fusion Genomic Features for ATP2A2-ARPC3


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for ATP2A2-ARPC3


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:110734542/chr12:110878193)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ATP2A2

P16615

ARPC3

O15145

FUNCTION: This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen (PubMed:16402920). Involved in autophagy in response to starvation. Upon interaction with VMP1 and activation, controls ER-isolation membrane contacts for autophagosome formation (PubMed:28890335). Also modulates ER contacts with lipid droplets, mitochondria and endosomes (PubMed:28890335). {ECO:0000269|PubMed:16402920, ECO:0000269|PubMed:28890335}.; FUNCTION: [Isoform 2]: Involved in the regulation of the contraction/relaxation cycle. Acts as a regulator of TNFSF11-mediated Ca(2+) signaling pathways via its interaction with TMEM64 which is critical for the TNFSF11-induced CREB1 activation and mitochondrial ROS generation necessary for proper osteoclast generation. Association between TMEM64 and SERCA2 in the ER leads to cytosolic Ca(2+) spiking for activation of NFATC1 and production of mitochondrial ROS, thereby triggering Ca(2+) signaling cascades that promote osteoclast differentiation and activation. {ECO:0000250|UniProtKB:O55143}.FUNCTION: Component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF) (PubMed:9230079). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility (PubMed:9230079). In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA (PubMed:29925947). The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs) (PubMed:29925947). {ECO:0000269|PubMed:29925947, ECO:0000269|PubMed:9230079}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneATP2A2chr12:110734542chr12:110878193ENST00000308664+5211_48154998.0Topological domainCytoplasmic
HgeneATP2A2chr12:110734542chr12:110878193ENST00000308664+52170_89154998.0Topological domainLumenal
HgeneATP2A2chr12:110734542chr12:110878193ENST00000395494+5191_481541016.0Topological domainCytoplasmic
HgeneATP2A2chr12:110734542chr12:110878193ENST00000395494+51970_891541016.0Topological domainLumenal
HgeneATP2A2chr12:110734542chr12:110878193ENST00000539276+5201_481541043.0Topological domainCytoplasmic
HgeneATP2A2chr12:110734542chr12:110878193ENST00000539276+52070_891541043.0Topological domainLumenal
HgeneATP2A2chr12:110734542chr12:110878193ENST00000308664+52149_69154998.0TransmembraneHelical%3B Name%3D1
HgeneATP2A2chr12:110734542chr12:110878193ENST00000308664+52190_110154998.0TransmembraneHelical%3B Name%3D2
HgeneATP2A2chr12:110734542chr12:110878193ENST00000395494+51949_691541016.0TransmembraneHelical%3B Name%3D1
HgeneATP2A2chr12:110734542chr12:110878193ENST00000395494+51990_1101541016.0TransmembraneHelical%3B Name%3D2
HgeneATP2A2chr12:110734542chr12:110878193ENST00000539276+52049_691541043.0TransmembraneHelical%3B Name%3D1
HgeneATP2A2chr12:110734542chr12:110878193ENST00000539276+52090_1101541043.0TransmembraneHelical%3B Name%3D2

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneATP2A2chr12:110734542chr12:110878193ENST00000308664+521111_253154998.0Topological domainCytoplasmic
HgeneATP2A2chr12:110734542chr12:110878193ENST00000308664+521274_295154998.0Topological domainLumenal
HgeneATP2A2chr12:110734542chr12:110878193ENST00000308664+521314_756154998.0Topological domainCytoplasmic
HgeneATP2A2chr12:110734542chr12:110878193ENST00000308664+521777_786154998.0Topological domainLumenal
HgeneATP2A2chr12:110734542chr12:110878193ENST00000308664+521808_827154998.0Topological domainCytoplasmic
HgeneATP2A2chr12:110734542chr12:110878193ENST00000308664+521851_896154998.0Topological domainLumenal
HgeneATP2A2chr12:110734542chr12:110878193ENST00000308664+521917_929154998.0Topological domainCytoplasmic
HgeneATP2A2chr12:110734542chr12:110878193ENST00000308664+521949_963154998.0Topological domainLumenal
HgeneATP2A2chr12:110734542chr12:110878193ENST00000308664+521985_1042154998.0Topological domainCytoplasmic
HgeneATP2A2chr12:110734542chr12:110878193ENST00000395494+519111_2531541016.0Topological domainCytoplasmic
HgeneATP2A2chr12:110734542chr12:110878193ENST00000395494+519274_2951541016.0Topological domainLumenal
HgeneATP2A2chr12:110734542chr12:110878193ENST00000395494+519314_7561541016.0Topological domainCytoplasmic
HgeneATP2A2chr12:110734542chr12:110878193ENST00000395494+519777_7861541016.0Topological domainLumenal
HgeneATP2A2chr12:110734542chr12:110878193ENST00000395494+519808_8271541016.0Topological domainCytoplasmic
HgeneATP2A2chr12:110734542chr12:110878193ENST00000395494+519851_8961541016.0Topological domainLumenal
HgeneATP2A2chr12:110734542chr12:110878193ENST00000395494+519917_9291541016.0Topological domainCytoplasmic
HgeneATP2A2chr12:110734542chr12:110878193ENST00000395494+519949_9631541016.0Topological domainLumenal
HgeneATP2A2chr12:110734542chr12:110878193ENST00000395494+519985_10421541016.0Topological domainCytoplasmic
HgeneATP2A2chr12:110734542chr12:110878193ENST00000539276+520111_2531541043.0Topological domainCytoplasmic
HgeneATP2A2chr12:110734542chr12:110878193ENST00000539276+520274_2951541043.0Topological domainLumenal
HgeneATP2A2chr12:110734542chr12:110878193ENST00000539276+520314_7561541043.0Topological domainCytoplasmic
HgeneATP2A2chr12:110734542chr12:110878193ENST00000539276+520777_7861541043.0Topological domainLumenal
HgeneATP2A2chr12:110734542chr12:110878193ENST00000539276+520808_8271541043.0Topological domainCytoplasmic
HgeneATP2A2chr12:110734542chr12:110878193ENST00000539276+520851_8961541043.0Topological domainLumenal
HgeneATP2A2chr12:110734542chr12:110878193ENST00000539276+520917_9291541043.0Topological domainCytoplasmic
HgeneATP2A2chr12:110734542chr12:110878193ENST00000539276+520949_9631541043.0Topological domainLumenal
HgeneATP2A2chr12:110734542chr12:110878193ENST00000539276+520985_10421541043.0Topological domainCytoplasmic
HgeneATP2A2chr12:110734542chr12:110878193ENST00000308664+521254_273154998.0TransmembraneHelical%3B Name%3D3
HgeneATP2A2chr12:110734542chr12:110878193ENST00000308664+521296_313154998.0TransmembraneHelical%3B Name%3D4
HgeneATP2A2chr12:110734542chr12:110878193ENST00000308664+521757_776154998.0TransmembraneHelical%3B Name%3D5
HgeneATP2A2chr12:110734542chr12:110878193ENST00000308664+521828_850154998.0TransmembraneHelical%3B Name%3D7
HgeneATP2A2chr12:110734542chr12:110878193ENST00000308664+521897_916154998.0TransmembraneHelical%3B Name%3D8
HgeneATP2A2chr12:110734542chr12:110878193ENST00000308664+521930_948154998.0TransmembraneHelical%3B Name%3D9
HgeneATP2A2chr12:110734542chr12:110878193ENST00000308664+521964_984154998.0TransmembraneHelical%3B Name%3D10
HgeneATP2A2chr12:110734542chr12:110878193ENST00000395494+519254_2731541016.0TransmembraneHelical%3B Name%3D3
HgeneATP2A2chr12:110734542chr12:110878193ENST00000395494+519296_3131541016.0TransmembraneHelical%3B Name%3D4
HgeneATP2A2chr12:110734542chr12:110878193ENST00000395494+519757_7761541016.0TransmembraneHelical%3B Name%3D5
HgeneATP2A2chr12:110734542chr12:110878193ENST00000395494+519828_8501541016.0TransmembraneHelical%3B Name%3D7
HgeneATP2A2chr12:110734542chr12:110878193ENST00000395494+519897_9161541016.0TransmembraneHelical%3B Name%3D8
HgeneATP2A2chr12:110734542chr12:110878193ENST00000395494+519930_9481541016.0TransmembraneHelical%3B Name%3D9
HgeneATP2A2chr12:110734542chr12:110878193ENST00000395494+519964_9841541016.0TransmembraneHelical%3B Name%3D10
HgeneATP2A2chr12:110734542chr12:110878193ENST00000539276+520254_2731541043.0TransmembraneHelical%3B Name%3D3
HgeneATP2A2chr12:110734542chr12:110878193ENST00000539276+520296_3131541043.0TransmembraneHelical%3B Name%3D4
HgeneATP2A2chr12:110734542chr12:110878193ENST00000539276+520757_7761541043.0TransmembraneHelical%3B Name%3D5
HgeneATP2A2chr12:110734542chr12:110878193ENST00000539276+520828_8501541043.0TransmembraneHelical%3B Name%3D7
HgeneATP2A2chr12:110734542chr12:110878193ENST00000539276+520897_9161541043.0TransmembraneHelical%3B Name%3D8
HgeneATP2A2chr12:110734542chr12:110878193ENST00000539276+520930_9481541043.0TransmembraneHelical%3B Name%3D9
HgeneATP2A2chr12:110734542chr12:110878193ENST00000539276+520964_9841541043.0TransmembraneHelical%3B Name%3D10


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Fusion Gene Sequence for ATP2A2-ARPC3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>7825_7825_1_ATP2A2-ARPC3_ATP2A2_chr12_110734542_ENST00000308664_ARPC3_chr12_110878193_ENST00000228825_length(transcript)=1898nt_BP=1137nt
GCGCGGGAGGAGGGAGCCGGGAGGAGGGGGCGGGGCCGCGCCGCCCGCGCCGCGCTGGGCGCTCTCGGCCAATGAGCGGCGTCCACATGC
CGCGGCGGCGGCGAAAGGGGAGGCAGCGGCCGATAAATGCTATTAGAGCAGCCGCCGCGGAGCCGTCCCCGACGCCACCTCCTTTTCCTT
CGCCGCAGTTTCCTCCGCCGCTGTCGGGCGTGCGGCGCTGAGGGACCCGGGCGAGCGCGCCGCGCACCGCCCCGCCGGCTCGCCTCCCTC
GCCGCGTTCCGCCCTCAGTGGTCTGCCGGGCGCCCCCTCCTCCGGCCCGGGCGGGGCCTCTGATCGCCTCAAGAGAGCGGGGAGGGGGCT
CGGGGGCCGCGGCCTGCCCTCCCGGCGGGCGGCTGAGGGCGAGGGAGGCCCTCCCTTCTGGCGAGGGGAGGGAGGGTGGGTCAGGAGCCC
CCAACCCGCCCTGCGGAGCTCGGGGCCGCGCGAGGGGCGGTTGTCTGGGGGAGGGGGCGCGGGGTGATTCAGCGCCCGGCGAGGCGGAAG
CGGCCGCAAGAGGAGGAGGGGAGAGCCCGTCCGCGCCTGGGCTCCCGGGGTGGCACGAGCCCGCGGCCGGAGTGCGAGGCGGAGGCGAGG
AGGCCGCGGGGACGGGAGGCGAGGCCGGCCGGGCCCCCGAAGCCATGGAGAACGCGCACACCAAGACGGTGGAGGAGGTGCTGGGCCACT
TCGGCGTCAACGAGAGTACGGGGCTGAGCCTGGAACAGGTCAAGAAGCTTAAGGAGAGATGGGGCTCCAACGAGTTACCGGCTGAAGAAG
GAAAAACCTTGCTGGAACTTGTGATTGAGCAGTTTGAAGACTTGCTAGTTAGGATTTTATTACTGGCAGCATGTATATCTTTTGTTTTGG
CTTGGTTTGAAGAAGGTGAAGAAACAATTACAGCCTTTGTAGAACCTTTTGTAATTTTACTCATATTAGTAGCCAATGCAATTGTGGGTG
TATGGCAGGAAAGAAATGCTGAAAATGCCATCGAAGCCCTTAAGGAATATGAGCCTGAAATGGGCAAAGTGTATCGACAGGACAGAAAGA
GTGTGCAGCGGATTAAAGCTAAAGACATAGTTCCTGGTGATATTGTAGAAATTGCTGCAAAAGATACAGATATTGTGGATGAAGCCATCT
ATTACTTCAAGGCCAATGTCTTCTTCAAAAACTATGAAATTAAGAATGAAGCTGATAGGACCTTGATATATATAACTCTCTACATTTCTG
AATGTCTGAAGAAACTGCAAAAGTGCAATTCCAAAAGCCAAGGTGAGAAAGAAATGTATACGCTGGGAATCACTAATTTTCCCATTCCTG
GAGAGCCTGGTTTTCCACTTAACGCAATTTATGCCAAACCTGCAAACAAACAGGAAGATGAAGTGATGAGAGCCTATTTACAACAGCTAA
GGCAAGAGACTGGACTGAGACTTTGTGAGAAAGTTTTCGACCCTCAGAATGATAAACCCAGCAAGTGGTGGACTTGCTTTGTGAAGAGAC
AGTTCATGAACAAGAGTCTTTCAGGACCTGGACAGTGAAGGGAGCCCGGGCAGCCACCGTCTCCAGAGCCCTGGGCAGCATTTTCCAGCA
AGATGTACACAATCTTTTGCCTTTATTTCGTAAAGTTTTATACAGAAGAGAGAAGAGCATGTCTTTACTTGAAAAACTCTTGATCAAGAA
TTTGGGTGGGAGAAAAGAAAGTGGGTTATCAAGGGTGATTTGAAATTTTCTGCAGCATTAAAGCTGGCGCTTAATAAGAATAAGTAATAA
TAAAGAAATTTCTAACATTCCATGTCAGAAAAACTTTATTGCCAGTCTTTGACATTCACTTACAATTTGTTTTGAGATAAAATTCACATT

>7825_7825_1_ATP2A2-ARPC3_ATP2A2_chr12_110734542_ENST00000308664_ARPC3_chr12_110878193_ENST00000228825_length(amino acids)=412AA_BP=269
MIASRERGGGSGAAACPPGGRLRAREALPSGEGREGGSGAPNPPCGARGRARGGCLGEGARGDSAPGEAEAAARGGGESPSAPGLPGWHE
PAAGVRGGGEEAAGTGGEAGRAPEAMENAHTKTVEEVLGHFGVNESTGLSLEQVKKLKERWGSNELPAEEGKTLLELVIEQFEDLLVRIL
LLAACISFVLAWFEEGEETITAFVEPFVILLILVANAIVGVWQERNAENAIEALKEYEPEMGKVYRQDRKSVQRIKAKDIVPGDIVEIAA
KDTDIVDEAIYYFKANVFFKNYEIKNEADRTLIYITLYISECLKKLQKCNSKSQGEKEMYTLGITNFPIPGEPGFPLNAIYAKPANKQED

--------------------------------------------------------------
>7825_7825_2_ATP2A2-ARPC3_ATP2A2_chr12_110734542_ENST00000395494_ARPC3_chr12_110878193_ENST00000228825_length(transcript)=1787nt_BP=1026nt
GGCAGCGGCCGATAAATGCTATTAGAGCAGCCGCCGCGGAGCCGTCCCCGACGCCACCTCCTTTTCCTTCGCCGCAGTTTCCTCCGCCGC
TGTCGGGCGTGCGGCGCTGAGGGACCCGGGCGAGCGCGCCGCGCACCGCCCCGCCGGCTCGCCTCCCTCGCCGCGTTCCGCCCTCAGTGG
TCTGCCGGGCGCCCCCTCCTCCGGCCCGGGCGGGGCCTCTGATCGCCTCAAGAGAGCGGGGAGGGGGCTCGGGGGCCGCGGCCTGCCCTC
CCGGCGGGCGGCTGAGGGCGAGGGAGGCCCTCCCTTCTGGCGAGGGGAGGGAGGGTGGGTCAGGAGCCCCCAACCCGCCCTGCGGAGCTC
GGGGCCGCGCGAGGGGCGGTTGTCTGGGGGAGGGGGCGCGGGGTGATTCAGCGCCCGGCGAGGCGGAAGCGGCCGCAAGAGGAGGAGGGG
AGAGCCCGTCCGCGCCTGGGCTCCCGGGGTGGCACGAGCCCGCGGCCGGAGTGCGAGGCGGAGGCGAGGAGGCCGCGGGGACGGGAGGCG
AGGCCGGCCGGGCCCCCGAAGCCATGGAGAACGCGCACACCAAGACGGTGGAGGAGGTGCTGGGCCACTTCGGCGTCAACGAGAGTACGG
GGCTGAGCCTGGAACAGGTCAAGAAGCTTAAGGAGAGATGGGGCTCCAACGAGTTACCGGCTGAAGAAGGAAAAACCTTGCTGGAACTTG
TGATTGAGCAGTTTGAAGACTTGCTAGTTAGGATTTTATTACTGGCAGCATGTATATCTTTTGTTTTGGCTTGGTTTGAAGAAGGTGAAG
AAACAATTACAGCCTTTGTAGAACCTTTTGTAATTTTACTCATATTAGTAGCCAATGCAATTGTGGGTGTATGGCAGGAAAGAAATGCTG
AAAATGCCATCGAAGCCCTTAAGGAATATGAGCCTGAAATGGGCAAAGTGTATCGACAGGACAGAAAGAGTGTGCAGCGGATTAAAGCTA
AAGACATAGTTCCTGGTGATATTGTAGAAATTGCTGCAAAAGATACAGATATTGTGGATGAAGCCATCTATTACTTCAAGGCCAATGTCT
TCTTCAAAAACTATGAAATTAAGAATGAAGCTGATAGGACCTTGATATATATAACTCTCTACATTTCTGAATGTCTGAAGAAACTGCAAA
AGTGCAATTCCAAAAGCCAAGGTGAGAAAGAAATGTATACGCTGGGAATCACTAATTTTCCCATTCCTGGAGAGCCTGGTTTTCCACTTA
ACGCAATTTATGCCAAACCTGCAAACAAACAGGAAGATGAAGTGATGAGAGCCTATTTACAACAGCTAAGGCAAGAGACTGGACTGAGAC
TTTGTGAGAAAGTTTTCGACCCTCAGAATGATAAACCCAGCAAGTGGTGGACTTGCTTTGTGAAGAGACAGTTCATGAACAAGAGTCTTT
CAGGACCTGGACAGTGAAGGGAGCCCGGGCAGCCACCGTCTCCAGAGCCCTGGGCAGCATTTTCCAGCAAGATGTACACAATCTTTTGCC
TTTATTTCGTAAAGTTTTATACAGAAGAGAGAAGAGCATGTCTTTACTTGAAAAACTCTTGATCAAGAATTTGGGTGGGAGAAAAGAAAG
TGGGTTATCAAGGGTGATTTGAAATTTTCTGCAGCATTAAAGCTGGCGCTTAATAAGAATAAGTAATAATAAAGAAATTTCTAACATTCC

>7825_7825_2_ATP2A2-ARPC3_ATP2A2_chr12_110734542_ENST00000395494_ARPC3_chr12_110878193_ENST00000228825_length(amino acids)=412AA_BP=269
MIASRERGGGSGAAACPPGGRLRAREALPSGEGREGGSGAPNPPCGARGRARGGCLGEGARGDSAPGEAEAAARGGGESPSAPGLPGWHE
PAAGVRGGGEEAAGTGGEAGRAPEAMENAHTKTVEEVLGHFGVNESTGLSLEQVKKLKERWGSNELPAEEGKTLLELVIEQFEDLLVRIL
LLAACISFVLAWFEEGEETITAFVEPFVILLILVANAIVGVWQERNAENAIEALKEYEPEMGKVYRQDRKSVQRIKAKDIVPGDIVEIAA
KDTDIVDEAIYYFKANVFFKNYEIKNEADRTLIYITLYISECLKKLQKCNSKSQGEKEMYTLGITNFPIPGEPGFPLNAIYAKPANKQED

--------------------------------------------------------------
>7825_7825_3_ATP2A2-ARPC3_ATP2A2_chr12_110734542_ENST00000539276_ARPC3_chr12_110878193_ENST00000228825_length(transcript)=1333nt_BP=572nt
CCCGTCCGCGCCTGGGCTCCCGGGGTGGCACGAGCCCGCGGCCGGAGTGCGAGGCGGAGGCGAGGAGGCCGCGGGGACGGGAGGCGAGGC
CGGCCGGGCCCCCGAAGCCATGGAGAACGCGCACACCAAGACGGTGGAGGAGGTGCTGGGCCACTTCGGCGTCAACGAGAGTACGGGGCT
GAGCCTGGAACAGGTCAAGAAGCTTAAGGAGAGATGGGGCTCCAACGAGTTACCGGCTGAAGAAGGAAAAACCTTGCTGGAACTTGTGAT
TGAGCAGTTTGAAGACTTGCTAGTTAGGATTTTATTACTGGCAGCATGTATATCTTTTGTTTTGGCTTGGTTTGAAGAAGGTGAAGAAAC
AATTACAGCCTTTGTAGAACCTTTTGTAATTTTACTCATATTAGTAGCCAATGCAATTGTGGGTGTATGGCAGGAAAGAAATGCTGAAAA
TGCCATCGAAGCCCTTAAGGAATATGAGCCTGAAATGGGCAAAGTGTATCGACAGGACAGAAAGAGTGTGCAGCGGATTAAAGCTAAAGA
CATAGTTCCTGGTGATATTGTAGAAATTGCTGCAAAAGATACAGATATTGTGGATGAAGCCATCTATTACTTCAAGGCCAATGTCTTCTT
CAAAAACTATGAAATTAAGAATGAAGCTGATAGGACCTTGATATATATAACTCTCTACATTTCTGAATGTCTGAAGAAACTGCAAAAGTG
CAATTCCAAAAGCCAAGGTGAGAAAGAAATGTATACGCTGGGAATCACTAATTTTCCCATTCCTGGAGAGCCTGGTTTTCCACTTAACGC
AATTTATGCCAAACCTGCAAACAAACAGGAAGATGAAGTGATGAGAGCCTATTTACAACAGCTAAGGCAAGAGACTGGACTGAGACTTTG
TGAGAAAGTTTTCGACCCTCAGAATGATAAACCCAGCAAGTGGTGGACTTGCTTTGTGAAGAGACAGTTCATGAACAAGAGTCTTTCAGG
ACCTGGACAGTGAAGGGAGCCCGGGCAGCCACCGTCTCCAGAGCCCTGGGCAGCATTTTCCAGCAAGATGTACACAATCTTTTGCCTTTA
TTTCGTAAAGTTTTATACAGAAGAGAGAAGAGCATGTCTTTACTTGAAAAACTCTTGATCAAGAATTTGGGTGGGAGAAAAGAAAGTGGG
TTATCAAGGGTGATTTGAAATTTTCTGCAGCATTAAAGCTGGCGCTTAATAAGAATAAGTAATAATAAAGAAATTTCTAACATTCCATGT

>7825_7825_3_ATP2A2-ARPC3_ATP2A2_chr12_110734542_ENST00000539276_ARPC3_chr12_110878193_ENST00000228825_length(amino acids)=297AA_BP=154
MENAHTKTVEEVLGHFGVNESTGLSLEQVKKLKERWGSNELPAEEGKTLLELVIEQFEDLLVRILLLAACISFVLAWFEEGEETITAFVE
PFVILLILVANAIVGVWQERNAENAIEALKEYEPEMGKVYRQDRKSVQRIKAKDIVPGDIVEIAAKDTDIVDEAIYYFKANVFFKNYEIK
NEADRTLIYITLYISECLKKLQKCNSKSQGEKEMYTLGITNFPIPGEPGFPLNAIYAKPANKQEDEVMRAYLQQLRQETGLRLCEKVFDP

--------------------------------------------------------------

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Fusion Gene PPI Analysis for ATP2A2-ARPC3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneATP2A2chr12:110734542chr12:110878193ENST00000308664+521575_594154.33333333333334998.0HAX1
HgeneATP2A2chr12:110734542chr12:110878193ENST00000395494+519575_594154.333333333333341016.0HAX1
HgeneATP2A2chr12:110734542chr12:110878193ENST00000539276+520575_594154.333333333333341043.0HAX1
HgeneATP2A2chr12:110734542chr12:110878193ENST00000308664+521787_807154.33333333333334998.0PLN
HgeneATP2A2chr12:110734542chr12:110878193ENST00000308664+521931_942154.33333333333334998.0PLN
HgeneATP2A2chr12:110734542chr12:110878193ENST00000395494+519787_807154.333333333333341016.0PLN
HgeneATP2A2chr12:110734542chr12:110878193ENST00000395494+519931_942154.333333333333341016.0PLN
HgeneATP2A2chr12:110734542chr12:110878193ENST00000539276+520787_807154.333333333333341043.0PLN
HgeneATP2A2chr12:110734542chr12:110878193ENST00000539276+520931_942154.333333333333341043.0PLN
HgeneATP2A2chr12:110734542chr12:110878193ENST00000308664+521788_1042154.33333333333334998.0TMEM64 and PDIA3
HgeneATP2A2chr12:110734542chr12:110878193ENST00000395494+519788_1042154.333333333333341016.0TMEM64 and PDIA3
HgeneATP2A2chr12:110734542chr12:110878193ENST00000539276+520788_1042154.333333333333341043.0TMEM64 and PDIA3


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ATP2A2-ARPC3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ATP2A2-ARPC3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource