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 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:RQCD1-CYP27A1 (FusionGDB2 ID:78254) |
Fusion Gene Summary for RQCD1-CYP27A1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: RQCD1-CYP27A1 | Fusion gene ID: 78254 | Hgene | Tgene | Gene symbol | RQCD1 | CYP27A1 | Gene ID | 9125 | 1593 |
| Gene name | CCR4-NOT transcription complex subunit 9 | cytochrome P450 family 27 subfamily A member 1 | |
| Synonyms | CAF40|CT129|RCD-1|RCD1|RQCD1 | CP27|CTX|CYP27 | |
| Cytomap | 2q35 | 2q35 | |
| Type of gene | protein-coding | protein-coding | |
| Description | CCR4-NOT transcription complex subunit 9RCD1 required for cell differentiation1 homologcancer/testis antigen 129cell differentiation protein RCD1 homologcell differentiation protein RQCD1 homologprotein involved in sexual development | sterol 26-hydroxylase, mitochondrial5-beta-cholestane-3-alpha, 7-alpha, 12-alpha-triol 26-hydroxylase5-beta-cholestane-3-alpha, 7-alpha, 12-alpha-triol 27-hydroxylasecholestanetriol 26-monooxygenasecytochrome P-450C27/25cytochrome P450 27cytochrome | |
| Modification date | 20200313 | 20200320 | |
| UniProtAcc | . | Q02318 | |
| Ensembl transtripts involved in fusion gene | ENST00000489687, ENST00000273064, ENST00000295701, ENST00000509807, ENST00000542068, | ENST00000258415, | |
| Fusion gene scores | * DoF score | 4 X 3 X 5=60 | 6 X 7 X 4=168 |
| # samples | 6 | 7 | |
| ** MAII score | log2(6/60*10)=0 | log2(7/168*10)=-1.26303440583379 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: RQCD1 [Title/Abstract] AND CYP27A1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | RQCD1(219433701)-CYP27A1(219674300), # samples:1 RQCD1(219433701)-CYP27A1(219676945), # samples:1 | ||
| Anticipated loss of major functional domain due to fusion event. | RQCD1-CYP27A1 seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF. RQCD1-CYP27A1 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF. RQCD1-CYP27A1 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | RQCD1 | GO:2000327 | positive regulation of nuclear receptor transcription coactivator activity | 18180299 |
| Tgene | CYP27A1 | GO:0006699 | bile acid biosynthetic process | 9660774|11412116 |
| Tgene | CYP27A1 | GO:0006707 | cholesterol catabolic process | 9660774 |
| Tgene | CYP27A1 | GO:0036378 | calcitriol biosynthetic process from calciol | 15465040 |
| Fusion gene breakpoints across RQCD1 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene breakpoints across CYP27A1 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | KIRC | TCGA-BP-4354-01A | RQCD1 | chr2 | 219433701 | + | CYP27A1 | chr2 | 219674300 | + |
| ChimerDB4 | KIRC | TCGA-BP-4354-01A | RQCD1 | chr2 | 219433701 | + | CYP27A1 | chr2 | 219676945 | + |
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Fusion Gene ORF analysis for RQCD1-CYP27A1 |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 3UTR-3CDS | ENST00000489687 | ENST00000258415 | RQCD1 | chr2 | 219433701 | + | CYP27A1 | chr2 | 219674300 | + |
| 3UTR-3CDS | ENST00000489687 | ENST00000258415 | RQCD1 | chr2 | 219433701 | + | CYP27A1 | chr2 | 219676945 | + |
| Frame-shift | ENST00000273064 | ENST00000258415 | RQCD1 | chr2 | 219433701 | + | CYP27A1 | chr2 | 219676945 | + |
| Frame-shift | ENST00000295701 | ENST00000258415 | RQCD1 | chr2 | 219433701 | + | CYP27A1 | chr2 | 219676945 | + |
| Frame-shift | ENST00000509807 | ENST00000258415 | RQCD1 | chr2 | 219433701 | + | CYP27A1 | chr2 | 219676945 | + |
| Frame-shift | ENST00000542068 | ENST00000258415 | RQCD1 | chr2 | 219433701 | + | CYP27A1 | chr2 | 219676945 | + |
| In-frame | ENST00000273064 | ENST00000258415 | RQCD1 | chr2 | 219433701 | + | CYP27A1 | chr2 | 219674300 | + |
| In-frame | ENST00000295701 | ENST00000258415 | RQCD1 | chr2 | 219433701 | + | CYP27A1 | chr2 | 219674300 | + |
| In-frame | ENST00000509807 | ENST00000258415 | RQCD1 | chr2 | 219433701 | + | CYP27A1 | chr2 | 219674300 | + |
| In-frame | ENST00000542068 | ENST00000258415 | RQCD1 | chr2 | 219433701 | + | CYP27A1 | chr2 | 219674300 | + |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000509807 | RQCD1 | chr2 | 219433701 | + | ENST00000258415 | CYP27A1 | chr2 | 219674300 | + | 2003 | 399 | 168 | 1739 | 523 |
| ENST00000273064 | RQCD1 | chr2 | 219433701 | + | ENST00000258415 | CYP27A1 | chr2 | 219674300 | + | 2003 | 399 | 168 | 1739 | 523 |
| ENST00000542068 | RQCD1 | chr2 | 219433701 | + | ENST00000258415 | CYP27A1 | chr2 | 219674300 | + | 1875 | 271 | 40 | 1611 | 523 |
| ENST00000295701 | RQCD1 | chr2 | 219433701 | + | ENST00000258415 | CYP27A1 | chr2 | 219674300 | + | 1708 | 104 | 50 | 1444 | 464 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000509807 | ENST00000258415 | RQCD1 | chr2 | 219433701 | + | CYP27A1 | chr2 | 219674300 | + | 0.007831016 | 0.99216896 |
| ENST00000273064 | ENST00000258415 | RQCD1 | chr2 | 219433701 | + | CYP27A1 | chr2 | 219674300 | + | 0.007831016 | 0.99216896 |
| ENST00000542068 | ENST00000258415 | RQCD1 | chr2 | 219433701 | + | CYP27A1 | chr2 | 219674300 | + | 0.00885094 | 0.99114907 |
| ENST00000295701 | ENST00000258415 | RQCD1 | chr2 | 219433701 | + | CYP27A1 | chr2 | 219674300 | + | 0.012106344 | 0.98789364 |
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Fusion Genomic Features for RQCD1-CYP27A1 |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| RQCD1 | chr2 | 219433701 | + | CYP27A1 | chr2 | 219674299 | + | 2.16E-07 | 0.99999976 |
| RQCD1 | chr2 | 219433701 | + | CYP27A1 | chr2 | 219676944 | + | 1.57E-09 | 1 |
| RQCD1 | chr2 | 219433701 | + | CYP27A1 | chr2 | 219674299 | + | 2.16E-07 | 0.99999976 |
| RQCD1 | chr2 | 219433701 | + | CYP27A1 | chr2 | 219676944 | + | 1.57E-09 | 1 |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
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| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for RQCD1-CYP27A1 |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:219433701/chr2:219674300) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| . | CYP27A1 |
| FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. | FUNCTION: Cytochrome P450 monooxygenase that catalyzes regio- and stereospecific hydroxylation of cholesterol and its derivatives. Hydroxylates (with R stereochemistry) the terminal methyl group of cholesterol side-chain in a three step reaction to yield at first a C26 alcohol, then a C26 aldehyde and finally a C26 acid (PubMed:9660774, PubMed:12077124, PubMed:21411718, PubMed:28190002). Regulates cholesterol homeostasis by catalyzing the conversion of excess cholesterol to bile acids via both the 'neutral' (classic) and the 'acid' (alternative) pathways (PubMed:9660774, PubMed:1708392, PubMed:11412116, PubMed:2019602, PubMed:7915755, PubMed:9186905, PubMed:9790667). May also regulate cholesterol homeostasis via generation of active oxysterols, which act as ligands for NR1H2 and NR1H3 nuclear receptors, modulating the transcription of genes involved in lipid metabolism (PubMed:9660774, PubMed:12077124). Plays a role in cholestanol metabolism in the cerebellum. Similarly to cholesterol, hydroxylates cholestanol and may facilitate sterol diffusion through the blood-brain barrier to the systemic circulation for further degradation (PubMed:28190002). Also hydroxylates retinal 7-ketocholesterol, a noxious oxysterol with pro-inflammatory and pro-apoptotic effects, and may play a role in its elimination from the retinal pigment epithelium (PubMed:21411718). May play a redundant role in vitamin D biosynthesis. Catalyzes 25-hydroxylation of vitamin D3 that is required for its conversion to a functionally active form (PubMed:15465040). {ECO:0000269|PubMed:11412116, ECO:0000269|PubMed:12077124, ECO:0000269|PubMed:15465040, ECO:0000269|PubMed:1708392, ECO:0000269|PubMed:2019602, ECO:0000269|PubMed:21411718, ECO:0000269|PubMed:28190002, ECO:0000269|PubMed:7915755, ECO:0000269|PubMed:9186905, ECO:0000269|PubMed:9660774, ECO:0000269|PubMed:9790667}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | CYP27A1 | chr2:219433701 | chr2:219674300 | ENST00000258415 | 0 | 9 | 384_398 | 85 | 532.0 | Region | Sterol-binding |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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Fusion Gene Sequence for RQCD1-CYP27A1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >78254_78254_1_RQCD1-CYP27A1_RQCD1_chr2_219433701_ENST00000273064_CYP27A1_chr2_219674300_ENST00000258415_length(transcript)=2003nt_BP=399nt AGTTGTCTTGCCGGGACTGTCCATCTTTTCCCGCCGTTCACTGGCTTTTGGAGGAGGGTCAGAGTTCACGCCGCTCTCTGGAAATAACTG CTCAAAGCCAGAAGTTGCGGGGACTAGTGGTCGCGGACGTCCTTCCGGTCCTAAATCTTAAGGGGCAAAGGACATACTCTGGGACTGTTA ACTAGGCCCTGGAGGCGGGAAGAGGATGTGTGGGTGGGGTCAGGGGTGAGAGGTCAGAGGGCCGCGAAGTGGGCGGAGCGAGCCGGAGTC GGATGGCGGCTACGGCGGCTCATTGTTTTCCGCTGCAGGGGTGCTGAAGGGGGGACGCGGGTCGGACGCGTCCGGCTGTGGAAGAGAGCG GCGGCCGCTCACAACATGCACAGCCTGGCGACGGCTGCGGTGCTTTACAAGGCCAAGTACGGTCCAATGTGGATGTCCTACTTAGGGCCT CAGATGCACGTGAACCTGGCCAGTGCCCCGCTCTTGGAGCAAGTGATGCGGCAAGAGGGCAAGTACCCAGTACGGAACGACATGGAGCTA TGGAAGGAGCACCGGGACCAGCACGACCTGACCTATGGGCCGTTCACCACGGAAGGACACCACTGGTACCAGCTGCGCCAGGCTCTGAAC CAGCGGTTGCTGAAGCCAGCGGAAGCAGCGCTCTATACGGATGCTTTCAATGAGGTGATTGATGACTTTATGACTCGACTGGACCAGCTG CGGGCAGAGAGTGCTTCGGGGAACCAGGTGTCGGACATGGCTCAACTCTTCTACTACTTTGCCTTGGAAGCTATTTGCTACATCCTGTTC GAGAAACGCATTGGCTGCCTGCAGCGATCCATCCCCGAGGACACCGTGACCTTCGTCAGATCCATCGGGTTAATGTTCCAGAACTCACTC TATGCCACCTTCCTCCCCAAGTGGACTCGCCCCGTGCTGCCTTTCTGGAAGCGATACCTGGATGGTTGGAATGCCATCTTTTCCTTTGGG AAGAAGCTGATTGATGAGAAGCTCGAAGATATGGAGGCCCAACTGCAGGCAGCAGGGCCAGATGGCATCCAGGTGTCTGGCTACCTGCAC TTCTTACTGGCCAGTGGACAGCTCAGTCCTCGGGAGGCCATGGGCAGCCTGCCTGAGCTGCTCATGGCTGGAGTGGACACGACATCCAAC ACGCTGACATGGGCCCTGTACCACCTCTCAAAGGACCCTGAGATCCAGGAGGCCTTGCACGAGGAAGTGGTGGGTGTGGTGCCAGCCGGG CAAGTGCCCCAGCACAAGGACTTTGCCCACATGCCGTTGCTCAAAGCTGTGCTTAAGGAGACTCTGCGTCTCTACCCTGTGGTCCCCACA AACTCCCGGATCATAGAAAAGGAAATTGAAGTTGATGGCTTCCTCTTCCCCAAGAACACCCAGTTTGTGTTCTGCCACTATGTGGTGTCC CGGGACCCCACTGCCTTCTCTGAGCCTGAAAGCTTCCAGCCCCACCGCTGGCTGAGAAACAGCCAGCCTGCTACCCCCAGGATCCAGCAC CCATTTGGCTCTGTGCCCTTTGGCTATGGGGTCCGGGCCTGCCTGGGCCGCAGGATTGCAGAGCTGGAGATGCAGCTACTCCTCGCAAGG CTGATCCAGAAGTACAAGGTGGTCCTGGCCCCGGAGACGGGGGAGTTGAAGAGTGTGGCCCGCATTGTCCTGGTTCCCAATAAGAAAGTG GGCCTGCAGTTCCTGCAGAGACAGTGCTGAGCTGAGTCTCCGCCTTGCTGGGGCTTGTCCTAGAGGCTCCAGCTCTGGCACAGTGGTTCC TGGCTGCTGCCATGTCTCAGATGAGGAGGGAGAGAAGGAGGCCGCCAGACTCGAGAGGTGGGAGGAACTCCTTGCACACACCCTGAGCTT TTGCCACTTCTATCATTTTTGAGCAACTCCCTCTCAGCTAAAAGGCCACCCCTTTATCGCATTGCTGTCCTTGGGTAGAATATAAAATAA >78254_78254_1_RQCD1-CYP27A1_RQCD1_chr2_219433701_ENST00000273064_CYP27A1_chr2_219674300_ENST00000258415_length(amino acids)=523AA_BP=1 MGLLTRPWRREEDVWVGSGVRGQRAAKWAERAGVGWRLRRLIVFRCRGAEGGTRVGRVRLWKRAAAAHNMHSLATAAVLYKAKYGPMWMS YLGPQMHVNLASAPLLEQVMRQEGKYPVRNDMELWKEHRDQHDLTYGPFTTEGHHWYQLRQALNQRLLKPAEAALYTDAFNEVIDDFMTR LDQLRAESASGNQVSDMAQLFYYFALEAICYILFEKRIGCLQRSIPEDTVTFVRSIGLMFQNSLYATFLPKWTRPVLPFWKRYLDGWNAI FSFGKKLIDEKLEDMEAQLQAAGPDGIQVSGYLHFLLASGQLSPREAMGSLPELLMAGVDTTSNTLTWALYHLSKDPEIQEALHEEVVGV VPAGQVPQHKDFAHMPLLKAVLKETLRLYPVVPTNSRIIEKEIEVDGFLFPKNTQFVFCHYVVSRDPTAFSEPESFQPHRWLRNSQPATP -------------------------------------------------------------- >78254_78254_2_RQCD1-CYP27A1_RQCD1_chr2_219433701_ENST00000295701_CYP27A1_chr2_219674300_ENST00000258415_length(transcript)=1708nt_BP=104nt TTTTCCGCTGCAGGGGTGCTGAAGGGGGGACGCGGGTCGGACGCGTCCGGCTGTGGAAGAGAGCGGCGGCCGCTCACAACATGCACAGCC TGGCGACGGCTGCGGTGCTTTACAAGGCCAAGTACGGTCCAATGTGGATGTCCTACTTAGGGCCTCAGATGCACGTGAACCTGGCCAGTG CCCCGCTCTTGGAGCAAGTGATGCGGCAAGAGGGCAAGTACCCAGTACGGAACGACATGGAGCTATGGAAGGAGCACCGGGACCAGCACG ACCTGACCTATGGGCCGTTCACCACGGAAGGACACCACTGGTACCAGCTGCGCCAGGCTCTGAACCAGCGGTTGCTGAAGCCAGCGGAAG CAGCGCTCTATACGGATGCTTTCAATGAGGTGATTGATGACTTTATGACTCGACTGGACCAGCTGCGGGCAGAGAGTGCTTCGGGGAACC AGGTGTCGGACATGGCTCAACTCTTCTACTACTTTGCCTTGGAAGCTATTTGCTACATCCTGTTCGAGAAACGCATTGGCTGCCTGCAGC GATCCATCCCCGAGGACACCGTGACCTTCGTCAGATCCATCGGGTTAATGTTCCAGAACTCACTCTATGCCACCTTCCTCCCCAAGTGGA CTCGCCCCGTGCTGCCTTTCTGGAAGCGATACCTGGATGGTTGGAATGCCATCTTTTCCTTTGGGAAGAAGCTGATTGATGAGAAGCTCG AAGATATGGAGGCCCAACTGCAGGCAGCAGGGCCAGATGGCATCCAGGTGTCTGGCTACCTGCACTTCTTACTGGCCAGTGGACAGCTCA GTCCTCGGGAGGCCATGGGCAGCCTGCCTGAGCTGCTCATGGCTGGAGTGGACACGACATCCAACACGCTGACATGGGCCCTGTACCACC TCTCAAAGGACCCTGAGATCCAGGAGGCCTTGCACGAGGAAGTGGTGGGTGTGGTGCCAGCCGGGCAAGTGCCCCAGCACAAGGACTTTG CCCACATGCCGTTGCTCAAAGCTGTGCTTAAGGAGACTCTGCGTCTCTACCCTGTGGTCCCCACAAACTCCCGGATCATAGAAAAGGAAA TTGAAGTTGATGGCTTCCTCTTCCCCAAGAACACCCAGTTTGTGTTCTGCCACTATGTGGTGTCCCGGGACCCCACTGCCTTCTCTGAGC CTGAAAGCTTCCAGCCCCACCGCTGGCTGAGAAACAGCCAGCCTGCTACCCCCAGGATCCAGCACCCATTTGGCTCTGTGCCCTTTGGCT ATGGGGTCCGGGCCTGCCTGGGCCGCAGGATTGCAGAGCTGGAGATGCAGCTACTCCTCGCAAGGCTGATCCAGAAGTACAAGGTGGTCC TGGCCCCGGAGACGGGGGAGTTGAAGAGTGTGGCCCGCATTGTCCTGGTTCCCAATAAGAAAGTGGGCCTGCAGTTCCTGCAGAGACAGT GCTGAGCTGAGTCTCCGCCTTGCTGGGGCTTGTCCTAGAGGCTCCAGCTCTGGCACAGTGGTTCCTGGCTGCTGCCATGTCTCAGATGAG GAGGGAGAGAAGGAGGCCGCCAGACTCGAGAGGTGGGAGGAACTCCTTGCACACACCCTGAGCTTTTGCCACTTCTATCATTTTTGAGCA >78254_78254_2_RQCD1-CYP27A1_RQCD1_chr2_219433701_ENST00000295701_CYP27A1_chr2_219674300_ENST00000258415_length(amino acids)=464AA_BP=1 MWKRAAAAHNMHSLATAAVLYKAKYGPMWMSYLGPQMHVNLASAPLLEQVMRQEGKYPVRNDMELWKEHRDQHDLTYGPFTTEGHHWYQL RQALNQRLLKPAEAALYTDAFNEVIDDFMTRLDQLRAESASGNQVSDMAQLFYYFALEAICYILFEKRIGCLQRSIPEDTVTFVRSIGLM FQNSLYATFLPKWTRPVLPFWKRYLDGWNAIFSFGKKLIDEKLEDMEAQLQAAGPDGIQVSGYLHFLLASGQLSPREAMGSLPELLMAGV DTTSNTLTWALYHLSKDPEIQEALHEEVVGVVPAGQVPQHKDFAHMPLLKAVLKETLRLYPVVPTNSRIIEKEIEVDGFLFPKNTQFVFC HYVVSRDPTAFSEPESFQPHRWLRNSQPATPRIQHPFGSVPFGYGVRACLGRRIAELEMQLLLARLIQKYKVVLAPETGELKSVARIVLV -------------------------------------------------------------- >78254_78254_3_RQCD1-CYP27A1_RQCD1_chr2_219433701_ENST00000509807_CYP27A1_chr2_219674300_ENST00000258415_length(transcript)=2003nt_BP=399nt AGTTGTCTTGCCGGGACTGTCCATCTTTTCCCGCCGTTCACTGGCTTTTGGAGGAGGGTCAGAGTTCACGCCGCTCTCTGGAAATAACTG CTCAAAGCCAGAAGTTGCGGGGACTAGTGGTCGCGGACGTCCTTCCGGTCCTAAATCTTAAGGGGCAAAGGACATACTCTGGGACTGTTA ACTAGGCCCTGGAGGCGGGAAGAGGATGTGTGGGTGGGGTCAGGGGTGAGAGGTCAGAGGGCCGCGAAGTGGGCGGAGCGAGCCGGAGTC GGATGGCGGCTACGGCGGCTCATTGTTTTCCGCTGCAGGGGTGCTGAAGGGGGGACGCGGGTCGGACGCGTCCGGCTGTGGAAGAGAGCG GCGGCCGCTCACAACATGCACAGCCTGGCGACGGCTGCGGTGCTTTACAAGGCCAAGTACGGTCCAATGTGGATGTCCTACTTAGGGCCT CAGATGCACGTGAACCTGGCCAGTGCCCCGCTCTTGGAGCAAGTGATGCGGCAAGAGGGCAAGTACCCAGTACGGAACGACATGGAGCTA TGGAAGGAGCACCGGGACCAGCACGACCTGACCTATGGGCCGTTCACCACGGAAGGACACCACTGGTACCAGCTGCGCCAGGCTCTGAAC CAGCGGTTGCTGAAGCCAGCGGAAGCAGCGCTCTATACGGATGCTTTCAATGAGGTGATTGATGACTTTATGACTCGACTGGACCAGCTG CGGGCAGAGAGTGCTTCGGGGAACCAGGTGTCGGACATGGCTCAACTCTTCTACTACTTTGCCTTGGAAGCTATTTGCTACATCCTGTTC GAGAAACGCATTGGCTGCCTGCAGCGATCCATCCCCGAGGACACCGTGACCTTCGTCAGATCCATCGGGTTAATGTTCCAGAACTCACTC TATGCCACCTTCCTCCCCAAGTGGACTCGCCCCGTGCTGCCTTTCTGGAAGCGATACCTGGATGGTTGGAATGCCATCTTTTCCTTTGGG AAGAAGCTGATTGATGAGAAGCTCGAAGATATGGAGGCCCAACTGCAGGCAGCAGGGCCAGATGGCATCCAGGTGTCTGGCTACCTGCAC TTCTTACTGGCCAGTGGACAGCTCAGTCCTCGGGAGGCCATGGGCAGCCTGCCTGAGCTGCTCATGGCTGGAGTGGACACGACATCCAAC ACGCTGACATGGGCCCTGTACCACCTCTCAAAGGACCCTGAGATCCAGGAGGCCTTGCACGAGGAAGTGGTGGGTGTGGTGCCAGCCGGG CAAGTGCCCCAGCACAAGGACTTTGCCCACATGCCGTTGCTCAAAGCTGTGCTTAAGGAGACTCTGCGTCTCTACCCTGTGGTCCCCACA AACTCCCGGATCATAGAAAAGGAAATTGAAGTTGATGGCTTCCTCTTCCCCAAGAACACCCAGTTTGTGTTCTGCCACTATGTGGTGTCC CGGGACCCCACTGCCTTCTCTGAGCCTGAAAGCTTCCAGCCCCACCGCTGGCTGAGAAACAGCCAGCCTGCTACCCCCAGGATCCAGCAC CCATTTGGCTCTGTGCCCTTTGGCTATGGGGTCCGGGCCTGCCTGGGCCGCAGGATTGCAGAGCTGGAGATGCAGCTACTCCTCGCAAGG CTGATCCAGAAGTACAAGGTGGTCCTGGCCCCGGAGACGGGGGAGTTGAAGAGTGTGGCCCGCATTGTCCTGGTTCCCAATAAGAAAGTG GGCCTGCAGTTCCTGCAGAGACAGTGCTGAGCTGAGTCTCCGCCTTGCTGGGGCTTGTCCTAGAGGCTCCAGCTCTGGCACAGTGGTTCC TGGCTGCTGCCATGTCTCAGATGAGGAGGGAGAGAAGGAGGCCGCCAGACTCGAGAGGTGGGAGGAACTCCTTGCACACACCCTGAGCTT TTGCCACTTCTATCATTTTTGAGCAACTCCCTCTCAGCTAAAAGGCCACCCCTTTATCGCATTGCTGTCCTTGGGTAGAATATAAAATAA >78254_78254_3_RQCD1-CYP27A1_RQCD1_chr2_219433701_ENST00000509807_CYP27A1_chr2_219674300_ENST00000258415_length(amino acids)=523AA_BP=1 MGLLTRPWRREEDVWVGSGVRGQRAAKWAERAGVGWRLRRLIVFRCRGAEGGTRVGRVRLWKRAAAAHNMHSLATAAVLYKAKYGPMWMS YLGPQMHVNLASAPLLEQVMRQEGKYPVRNDMELWKEHRDQHDLTYGPFTTEGHHWYQLRQALNQRLLKPAEAALYTDAFNEVIDDFMTR LDQLRAESASGNQVSDMAQLFYYFALEAICYILFEKRIGCLQRSIPEDTVTFVRSIGLMFQNSLYATFLPKWTRPVLPFWKRYLDGWNAI FSFGKKLIDEKLEDMEAQLQAAGPDGIQVSGYLHFLLASGQLSPREAMGSLPELLMAGVDTTSNTLTWALYHLSKDPEIQEALHEEVVGV VPAGQVPQHKDFAHMPLLKAVLKETLRLYPVVPTNSRIIEKEIEVDGFLFPKNTQFVFCHYVVSRDPTAFSEPESFQPHRWLRNSQPATP -------------------------------------------------------------- >78254_78254_4_RQCD1-CYP27A1_RQCD1_chr2_219433701_ENST00000542068_CYP27A1_chr2_219674300_ENST00000258415_length(transcript)=1875nt_BP=271nt GTCCTTCCGGTCCTAAATCTTAAGGGGCAAAGGACATACTCTGGGACTGTTAACTAGGCCCTGGAGGCGGGAAGAGGATGTGTGGGTGGG GTCAGGGGTGAGAGGTCAGAGGGCCGCGAAGTGGGCGGAGCGAGCCGGAGTCGGATGGCGGCTACGGCGGCTCATTGTTTTCCGCTGCAG GGGTGCTGAAGGGGGGACGCGGGTCGGACGCGTCCGGCTGTGGAAGAGAGCGGCGGCCGCTCACAACATGCACAGCCTGGCGACGGCTGC GGTGCTTTACAAGGCCAAGTACGGTCCAATGTGGATGTCCTACTTAGGGCCTCAGATGCACGTGAACCTGGCCAGTGCCCCGCTCTTGGA GCAAGTGATGCGGCAAGAGGGCAAGTACCCAGTACGGAACGACATGGAGCTATGGAAGGAGCACCGGGACCAGCACGACCTGACCTATGG GCCGTTCACCACGGAAGGACACCACTGGTACCAGCTGCGCCAGGCTCTGAACCAGCGGTTGCTGAAGCCAGCGGAAGCAGCGCTCTATAC GGATGCTTTCAATGAGGTGATTGATGACTTTATGACTCGACTGGACCAGCTGCGGGCAGAGAGTGCTTCGGGGAACCAGGTGTCGGACAT GGCTCAACTCTTCTACTACTTTGCCTTGGAAGCTATTTGCTACATCCTGTTCGAGAAACGCATTGGCTGCCTGCAGCGATCCATCCCCGA GGACACCGTGACCTTCGTCAGATCCATCGGGTTAATGTTCCAGAACTCACTCTATGCCACCTTCCTCCCCAAGTGGACTCGCCCCGTGCT GCCTTTCTGGAAGCGATACCTGGATGGTTGGAATGCCATCTTTTCCTTTGGGAAGAAGCTGATTGATGAGAAGCTCGAAGATATGGAGGC CCAACTGCAGGCAGCAGGGCCAGATGGCATCCAGGTGTCTGGCTACCTGCACTTCTTACTGGCCAGTGGACAGCTCAGTCCTCGGGAGGC CATGGGCAGCCTGCCTGAGCTGCTCATGGCTGGAGTGGACACGACATCCAACACGCTGACATGGGCCCTGTACCACCTCTCAAAGGACCC TGAGATCCAGGAGGCCTTGCACGAGGAAGTGGTGGGTGTGGTGCCAGCCGGGCAAGTGCCCCAGCACAAGGACTTTGCCCACATGCCGTT GCTCAAAGCTGTGCTTAAGGAGACTCTGCGTCTCTACCCTGTGGTCCCCACAAACTCCCGGATCATAGAAAAGGAAATTGAAGTTGATGG CTTCCTCTTCCCCAAGAACACCCAGTTTGTGTTCTGCCACTATGTGGTGTCCCGGGACCCCACTGCCTTCTCTGAGCCTGAAAGCTTCCA GCCCCACCGCTGGCTGAGAAACAGCCAGCCTGCTACCCCCAGGATCCAGCACCCATTTGGCTCTGTGCCCTTTGGCTATGGGGTCCGGGC CTGCCTGGGCCGCAGGATTGCAGAGCTGGAGATGCAGCTACTCCTCGCAAGGCTGATCCAGAAGTACAAGGTGGTCCTGGCCCCGGAGAC GGGGGAGTTGAAGAGTGTGGCCCGCATTGTCCTGGTTCCCAATAAGAAAGTGGGCCTGCAGTTCCTGCAGAGACAGTGCTGAGCTGAGTC TCCGCCTTGCTGGGGCTTGTCCTAGAGGCTCCAGCTCTGGCACAGTGGTTCCTGGCTGCTGCCATGTCTCAGATGAGGAGGGAGAGAAGG AGGCCGCCAGACTCGAGAGGTGGGAGGAACTCCTTGCACACACCCTGAGCTTTTGCCACTTCTATCATTTTTGAGCAACTCCCTCTCAGC >78254_78254_4_RQCD1-CYP27A1_RQCD1_chr2_219433701_ENST00000542068_CYP27A1_chr2_219674300_ENST00000258415_length(amino acids)=523AA_BP=1 MGLLTRPWRREEDVWVGSGVRGQRAAKWAERAGVGWRLRRLIVFRCRGAEGGTRVGRVRLWKRAAAAHNMHSLATAAVLYKAKYGPMWMS YLGPQMHVNLASAPLLEQVMRQEGKYPVRNDMELWKEHRDQHDLTYGPFTTEGHHWYQLRQALNQRLLKPAEAALYTDAFNEVIDDFMTR LDQLRAESASGNQVSDMAQLFYYFALEAICYILFEKRIGCLQRSIPEDTVTFVRSIGLMFQNSLYATFLPKWTRPVLPFWKRYLDGWNAI FSFGKKLIDEKLEDMEAQLQAAGPDGIQVSGYLHFLLASGQLSPREAMGSLPELLMAGVDTTSNTLTWALYHLSKDPEIQEALHEEVVGV VPAGQVPQHKDFAHMPLLKAVLKETLRLYPVVPTNSRIIEKEIEVDGFLFPKNTQFVFCHYVVSRDPTAFSEPESFQPHRWLRNSQPATP -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for RQCD1-CYP27A1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for RQCD1-CYP27A1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for RQCD1-CYP27A1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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