FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:RRM2B-ZNF704 (FusionGDB2 ID:78323)

Fusion Gene Summary for RRM2B-ZNF704

check button Fusion gene summary
Fusion gene informationFusion gene name: RRM2B-ZNF704
Fusion gene ID: 78323
HgeneTgene
Gene symbol

RRM2B

ZNF704

Gene ID

50484

619279

Gene nameribonucleotide reductase regulatory TP53 inducible subunit M2Bzinc finger protein 704
SynonymsMTDPS8A|MTDPS8B|P53R2Gig1
Cytomap

8q22.3

8q21.13

Type of geneprotein-codingprotein-coding
Descriptionribonucleoside-diphosphate reductase subunit M2 BTP53-inducible ribonucleotide reductase M2 Bp53-inducible ribonucleotide reductase small subunit 2 homologp53-inducible ribonucleotide reductase small subunit 2 short form betap53-inducible ribonucleotizinc finger protein 704
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000251810, ENST00000395912, 
ENST00000519317, ENST00000519962, 
ENST00000520336, ENST00000327835, 
Fusion gene scores* DoF score4 X 3 X 4=485 X 5 X 4=100
# samples 46
** MAII scorelog2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(6/100*10)=-0.736965594166206
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: RRM2B [Title/Abstract] AND ZNF704 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointRRM2B(103231042)-ZNF704(81555364), # samples:3
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across RRM2B (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across ZNF704 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUSCTCGA-77-8009-01ARRM2Bchr8

103231042

-ZNF704chr8

81555364

-
ChimerDB4LUSCTCGA-77-8009RRM2Bchr8

103231042

-ZNF704chr8

81555364

-


Top

Fusion Gene ORF analysis for RRM2B-ZNF704

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000251810ENST00000520336RRM2Bchr8

103231042

-ZNF704chr8

81555364

-
5CDS-intronENST00000395912ENST00000520336RRM2Bchr8

103231042

-ZNF704chr8

81555364

-
In-frameENST00000251810ENST00000327835RRM2Bchr8

103231042

-ZNF704chr8

81555364

-
In-frameENST00000395912ENST00000327835RRM2Bchr8

103231042

-ZNF704chr8

81555364

-
intron-3CDSENST00000519317ENST00000327835RRM2Bchr8

103231042

-ZNF704chr8

81555364

-
intron-3CDSENST00000519962ENST00000327835RRM2Bchr8

103231042

-ZNF704chr8

81555364

-
intron-intronENST00000519317ENST00000520336RRM2Bchr8

103231042

-ZNF704chr8

81555364

-
intron-intronENST00000519962ENST00000520336RRM2Bchr8

103231042

-ZNF704chr8

81555364

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000251810RRM2Bchr8103231042-ENST00000327835ZNF704chr881555364-140509281301134334
ENST00000395912RRM2Bchr8103231042-ENST00000327835ZNF704chr881555364-136505280734244

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000251810ENST00000327835RRM2Bchr8103231042-ZNF704chr881555364-0.0009679240.99903214
ENST00000395912ENST00000327835RRM2Bchr8103231042-ZNF704chr881555364-0.0006935450.99930644

Top

Fusion Genomic Features for RRM2B-ZNF704


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for RRM2B-ZNF704


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr8:103231042/chr8:81555364)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneZNF704chr8:103231042chr8:81555364ENST0000032783569383_387344413.0MotifCR1
TgeneZNF704chr8:103231042chr8:81555364ENST0000032783569401_405344413.0MotifCR2

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneZNF704chr8:103231042chr8:81555364ENST0000032783569318_412344413.0RegionSufficient for binding to RE2 sequence motifs
TgeneZNF704chr8:103231042chr8:81555364ENST0000032783569193_218344413.0Zinc fingerC2H2-type


Top

Fusion Gene Sequence for RRM2B-ZNF704


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>78323_78323_1_RRM2B-ZNF704_RRM2B_chr8_103231042_ENST00000251810_ZNF704_chr8_81555364_ENST00000327835_length(transcript)=14050nt_BP=928nt
GGCTGGCCGAAGTTAGGCGGAGCCCCGAGGCGGGGGAGGCGGGGCCGGGCCGGCGCAGGGAGAGTCACTCAATGGACAGGCGAGAAAGCA
GGACCGGCGCGGCGGGGCGGGGCCGGCCGAGTCCCTAGAGCTGGGGGCGGGGCGGACCCAGCGGACCAGCGGACCACCTGGGTGCTGTCG
TAGTTGGAGGTGGCCTGAGGAGCTCAGTTCCCTCAGCGCCCGTAGCTTCGGCGGAGTCTGCGCGATGGGCGACCCGGAAAGGCCGGAAGC
GGCCGGGCTGGATCAGGATGAGAGATCATCTTCAGACACCAACGAAAGTGAAATAAAGTCAAATGAAGAGCCACTCCTAAGAAAGAGTTC
TCGCCGGTTTGTCATCTTTCCAATCCAGTACCCTGATATTTGGAAAATGTATAAACAGGCACAGGCTTCCTTCTGGACAGCAGAAGAGGT
CGACTTATCAAAGGATCTCCCTCACTGGAACAAGCTTAAAGCAGATGAGAAGTACTTCATCTCTCACATCTTAGCCTTTTTTGCAGCCAG
TGATGGAATTGTAAATGAAAATTTGGTGGAGCGCTTTAGTCAGGAGGTGCAGGTTCCAGAGGCTCGCTGTTTCTATGGCTTTCAAATTCT
CATCGAGAATGTTCACTCAGAGATGTACAGTTTGCTGATAGACACTTACATCAGAGATCCCAAGAAAAGGGAATTTTTATTTAATGCAAT
TGAAACCATGCCCTATGTTAAGAAAAAAGCAGATTGGGCCTTGCGATGGATAGCAGATAGAAAATCTACTTTTGGGGAAAGAGTGGTGGC
CTTTGCTGCTGTAGAAGGAGTTTTCTTCTCAGGATCTTTTGCTGCTATATTCTGGCTAAAGAAGAGAGGTCTTATGCCAGGACTCACTTT
TTCCAATGAACTCATCAGCAGAGATGAAGTGTCACCCACACATCATCCGGTGGGCACAGGAGAGCAGAGACAGCATGCGCACACGGTCCT
GTCCTCCCCACCCAGAGGCACAGTCAGCTTAAGGAAGCCCAGGGGAGAGGGCAAAAAGTGTCGGAAGGTGTACGGGATGGAGAACCGAGA
CATGTGGTGTACCGCCTGCCGCTGGAAGAAGGCCTGCCAGAGGTTCCTCGACTGAGAGACCCCCAGGCAGAGGGGCTCAGGGCCCTGAGC
CGCTCCTGCCCTGGCCTGCCACTGCAGGTGTTGGAAAGAGCTTTTCCTACTGAATAAAACACAGTTGAAGCCAGGAAAAGCCCTTTCAGG
AACCTTGGAGGAATAACAGCAAAAACACAGAAAAATTGTTTAAGTCACCACCTATGACAAAAGAAAGTTGCTCTTACTGAGAACCCAGCT
TGGAGCAGCTATAACTAGTTTTTTTTCCTTCAAAAGAAAAGTCAACTTTTTTTGCTGTATGTCTAGACTTAAAACTGTGGACTTCTGTAG
CAATTGAACCAACAAAGCCCATTTTACCTAGAAAGGAGGCATATTTTGATAAGCTTTCTGAATTATGCCATTTTCAAGATTTTTTTGACA
CTTAAAAAACAAGCTACAGGTTATTCAGTAGCATTTGTACAAAGATCAATACTTACTTTTGTTGTGAATAATCTTTTCCGTATCTTCCAT
TTGACTTCTTGGAGCAGTATATGTCAGGATGTGTTGCAAGACAGCGCAGCACTCTGGGCATCTTTTCTATGGCTTTTTGTTTGTTTTTCT
TTTAAGAATGGCCCCACACTGAACCATGGTAGAGCTATTAGTTTGTAGGGCCCCAGATGGCATAAACTCGAGAAGGGATTGTCCACGGAA
ATCACCAGCAGACTTCAGCCCGAAGCTGAGTTCAGGAAGTCCAGCTGTCACTGTTGGGAAACATCTAGGAGTCTTCCTTGGATCCATAAG
AAGCTCTTCCCCTAAAGGCAGCACAGCTAACTCTACTCTCTACCTGCCACAACTCAGTCAAGAATTGGCACCTGTAGCCATCTGGGTAAG
CCTCGATGCTTCTTTCAGGGATGTGACACAAATGGCAACTCGGAGCTATTTGTTACTGCTTGTCTGTCAAGATTGTAGCCAGGTTAATGG
GTCATTTTCCTTCTCTCCAGACTCCACCACTGACTGATTTCAGAAGAGGTAGAGAACTCCAAACTGTCCCAGCAGGTTTGCTTTAGACAA
CAGAGCACAGCCCACATGGCCCTACCTGTTCAGAAAGTCATGTTAGATCAACAAACCACTTCCATTCTGAGTGCACTTTTATAGGTTTTA
TGCTTTAGCATGTCCGGGAGATGAGTTAATTAACAATATAAACATTATGTGAGTAAATGGAAGGTCCAAACTTTAAGTTTTTCTTATAAA
AATATTGGAGCTATTCATTTAAGAATTTGCTCAAAAGGGAACATAACGCCAAAAGGAAAATGCATGTAGGTATAGGAATTTCTCAGTTTA
GTAGGGCCAGGGCTTGCACTATGTTCCATTTATTGGGCTTCGTAACTTACTTGCTTGTTTGTTTGGGGGATAGTGGTGTGGGGAGAGGGG
AGTCGTCAAGCCCTATAAATAAGCTCATTCTCTATCTACCCGACTCTCAATTGCCCTGCTAAAGAGTTATTTCTCCTATACCTATGCAAA
GTAGGAAGAGCACCTTATAGGAGGCACTGTATAGGGACAGGGGACATGGGATCAGCCATAGGAATGTTAAATGAAATTGCACAGAGGAAA
GTTTAATATATGTCTAGAGATTATACATACACTTTTTTAAGCGTAAAAAGAAGACATCTAGTAATGACAGATATTCTTTTTATATACAAG
CAAAAGAAAGTATAAGGAGGTTCTACAGTGCAACATCCACAATCTGTGCATTCACATATTATGGGACTTTTATTTTTTAAACTCTCATAT
AAATTTTTTAAAATTACTCCTTGGAAGAGATCCTGGTTTTTTTCTTCATTTATTTTTTTCTTTAAAAACATTTATTTTAAGAGAAGAGAA
AAAGAGCTTCATCTAATTTTGCATCTTGATTACCAATCAGTACTAGTCACAGCACCAGCAATACTGTATGTTTTAGACTGACAAGGTCAG
CCAGGAAATGGCATTTTTTTAAACGCAGAAATGTGTTTGTTTCCTCTACTCTAACACGTCCTTTCTCCTCCTGGTGTCCTGTCACCCCCC
ATGCAGCACCACTGATGCGAGATGATGCTCTGGCCTGGTCCAGGAAGCCCTGAGCCATGGGCAGATTGCCCAGTGGCCTTGGGCGGCCAG
AGCTTGTCACCTGTTTAAACAAGTTCACCATGTGTTTAAATGACAGGGTACAGTCCTGGACCAGAGGTTTTTCTCTTCAGCAAAGCTCCC
TGGCCCTTGATCGTTGGACTGTTACTAATAGAAAAAGATTCAAGTCATGAAGTATAAAATCCATCCCCCATCCCAGAACTTTGAAACACA
AGGAGGGAGAGATCTTTGCTATGGAGCAGTCCTGGAGCAAAGCCCCGTGGCTTCCACCCCCAGATATATACCCCATAAGTAGTGCTGAGC
TCCAGCTTAGCTGAGCCAAGCTCAGTCCTTATCTGGTGTTCAGCCAGTGCACAGGTATAAGCAGAACTACAGAGCTGAATGTAGCTTCCC
TGGGATCTCTTCTCCTTTCTAAAGCATTTTTCACACAGTTCTGTACCTCCTACCCAAGTTGGGGCTGCTTTCTGCCTGCTAGCCCACGGC
TCTGTGTACTTTCTTTTCTGGCTTCAGGTGCAGACAGACCCTCAGTACCTTCCTGGACACAGACACATATTCCCTGGACCAAGGCGTGGA
ATAACTAGTAGACCACCAAGCCACAGGTGGCTGGTCTTGAAGAAAAGGGATTATACTCCTTACAGGCCACCCAGAAAGCTATGAATTCCA
ATATACACCACTGATCGTGCAAGTTAGGGTTTTTTTTTTTTAAACGTAGCATTATTTTGTTATATTTTGGAACTAAATGAAGTGCCAAAT
TAACCAGACATTCGTTTGATGCCATCTCTGTGGAACCAAGTTCTCTGTGTGTGTTCGTTTGGCTGGGAGGAGGGGGAGGACTGGGCAGAC
TGCTCCCACAGCAGGCTGGCAGTGGAACTGGAGCCCTGGCCACCGCAGGGAGCTCAGAGGCCAATCTACGCAAAAGGCATGCAAAACAAT
GGATTCTGGTCCCAAAATATTTCTAAGTAAGGCATGATGTAGCCTTTTGATTTTTTTTTTATCCTTTGACACCCCAGCCTTCAGAAAAGG
TTTTTCATCTCTCTCCAAAGAAGTCATTTCATAGTGACTGACAGGACATTCTCCAGAGAGCGACAAAGCAGAGTGGCCAGCAGGCAGTGG
TGTTAAGCCTTGGGCCTTCCCAGCAGATGTGTGCTGCATTGGTGGGTGGGAGGCAGTGTGACAGCCTGGAGAAAACACACAGGTAGCAAG
GGAGTCAGGGGGGAGGTACAAGAGGGCTGTGGACACCTGGCTCTTGCTCATCTTCTTGGTGCTGATCAGCTGGTGGTCACCATCCCTAAG
TACCTCCCAGGGAGCTGCCATTTTCTCCTCTGGGAGCAGCTGCCTGAAGCAAGGAGAGAATGACCTGAAGGGAAGTACCTCCGGCCAAGA
GTGCAGGGCTGCTGTGCCTAGCCTGAGCGGGCCATCTCTAGCAGATATGGACTTCTCTCCACCACACTAGCTGAAAAGTTTTCTCCCTTG
GTTGGCAAAAGCCAGTGTCAGGAAAAAAGCTGTGGGTTTCTGACCAAGAATGTGTGCGCTTAGCTGCAAAGTGCCTGTCAGCAGCTCCAG
GCACCAACAAGGTGCCCTTTTATTAGACAATTCCTGCCCGAACATAACCATATTGCAGATGAAAATTTTCAATAGAGAATGACACAATTC
TTGACCTTTCTAAAAACTTTTCAAAGAGATAGTCACATGTGTATATGTTGCAAAAGATTTTTGAAACTGAAATGTCCTCCATTAAATCTC
AAGAGCACTCGAGTTTTAAGTCTGCTGTTTCTGGTGTCACACTAAGACACACTTTTGAAAGCAGCCCTGGGTTCTGAATTAGTTGGCACT
GCTGAATCCATGTTCCCCCTTCATCAGACTCCAAAGTGCAGCATTCACTTGCAAAGGTTGAGAGAAAAGTGGCCAGAATTGTACATATAA
CAGAGAATACCTTGAGAATAGTAGCAAAATACTGTAAATAATATTCATTTCCTCAGGGAAAAATAAAGGGCATGCAAAAATAGGTCTGGA
GACTCCTGAAACTAGGAAGAATTTTGTTATCACTAAAGTCTTTTATAGTCAGAACAATTTTTTTTTCAAATGAACATGGTATCATTTCAA
GACAAATTTATGTGAACTGGGCAGTACTGACATTTGTGAGGCATAGGGGAGTGCCCTGGGAAAACGGTTTGGAGCTGACCTGTAGCCTAA
GGCTAACATTTGAACCACAGGTGCAATGCCTGGGGGTGGGGGAGGGGGACGGGGTGGGGGTGGTATTCCTAGACTCACGTAAGGCTTTTT
CTGAATGTAATTGTGAATACAAAGCCTTGCTGGTCCTTTTTATCATTACCCAATGGATGACTGTTTATTAGCTATCAGCAGAATTCCGTA
GGCGAAAGCAAGCCGTGAACGATGTACATTTTGCTTTAATAGCATGTTAGCGAACAAACTTCCATGGACTTTTGTGGACAAGGTGCTGCT
TTTTCTCATGACCCTGTAGAATTGCTATCGACCACATCTTCTGTAGCACTGACCTGTGTGAACTCAGGGAAGAATTTGTGCATACAAATG
AGTGGAAACAGAGCAGGATTCATGAATATGAATGAGAATGTGAATCATTTTGGAGAATGCCCTGGGCACACGGGTCAACTGGAAATTTCA
TTTCTCTAAGAAAGTAGCCCTACCAGCGGCACGGACTGTTCCTGTTCCTCATACCTGTGGGGATTCCTCCATATTGGAACTGTTTCATGT
ATCTTTTTTGCATTGTAACTAGCCAAACCTGAAGTCAGTAAATAAAATGAGATTAGCACTTTTTTTAGGTACCAGTTGTATCACTGAGTA
ATGCACACCAATAGAGCAAGAAAGTATAAAATGTATTTAAGACCAACTGGTTTGCTTATTATGACTGACTTTGAAAAAGCCCATATCCAA
TGATATACATGCTTTAAAAGGTATATCTATCGTAGGACCAGGAACCAAAATGGGAATTTTACTTCTGGTCCTGTTTTGTAAATAGTTCCT
TTTTTTGAAGACAATCTCATGTTTTATAACTTTTGTTGTGGGTCTGAGAATCACAATGGTAATATGTCTTGGCAAAACATAACCTTTAAA
TACAAAAACAATTATAACTTAATTTTCCAAATAAAACAAGAAATACACTGATTAGGCTTCTACAGTTCTAAGAGACATGACACTTTGGTA
ATAAGCGTCAGTACTCTACTTCTCAAGTTAACTGGAAATATTTTACAAGATGCAGTGTTTTGTAATCACAAAGAACGCAGACATTTTGTG
AGAAATGACCTTGGTTTTATACATTGTAGCTTATTTTTTAAAATATAGTATTTTACCAGGCAGGAAGTATTAATATTATAAGTAATTCTT
GCTCACCAAACAAAGGGCTATGTCTCTTTTAAGCAAATGTTTTGATGCATATCTTTTTAATTAACCCTCTGCAGCAAGGGTAGAAATACA
GATCAGATGGAATGGGTATTATAGGAGAATCAAGATAGCAACAGCTACTCCTTTTACCATTACTAGTGTGTTTTCAAAGTATGGAAAAAG
ATGCCTGAAGAGTCATTTTATATATTTTAAATCTAAAAAGTGTTAACAGGTATGCTTATAGGCCATGGGAGAAATATTCTTATAAATTTT
TTAGTGTAAAATGATAAATTCTGTGTCACAAAGACAAGTTTACCACTTGACCTACCAGAATCACAGATACTTGCATTTAACTAGCAAGTA
TCATTTGGTGGAAATTTCTAAAATCATAGTAGACAGGCCCAAAGATAGAATTCTTAGGTGATCAGTAGTGTTTAAAATAATTTTGTCCTC
AGCACTAACTATATAACTGTAATTTCTACATAAGAACAAGTGCTTCCAAAATATAGTGGAGGGAAAAAATAAAAAAGGAAAATAAAAAAA
CAAAACAAAAAGAACAAGTGCTTGATTTTTCACTGTGAAGAACTAGCAGGCACATGAGGTTGTGATCAGAAAGTGACTGAGTTCCCAAGA
ACCAGGAAACAGAGGGGAGTTGTGAAGAGTTTATTAAAACTGTACAAATAATTCAGAGCTTTGCCAAAACCATTTCATAATGCTGTACAG
TTTTTTCAAGCCCACTCACTGTTAAAACAAGAAAGCACCTTTTCTTTCTAAGATTTTAGTAATCCAAAAGCTAGCCTAATTAGCCAAGTA
TGCAGATAACATCAAAAGCAAAGCTGAGATAGAACAGCCATACACCCGTTGGGCAGCTCTTATGAGGTGGTCAGAAGGTCACTCAGACCT
TGGTTTCAAATAGGCTTTAGAATCTGCACACTTGAGGACTAGAAATGCACAGAGTTAGGGAAAGCCATGTACAGGCTTGGCTCCTAGTCT
TTGAGATGAGGCGTCTTGCAAATCTCTGTTTTCACTCCTTGGAATGTCTCCATTGTTAGCATTAAAGTCCCCAAGAAGTTTTTATTGCTG
TACGGTTTTGAACCCAATGAGTCTCATTTCCAAAAGATTCCTAATTCTATATAGGAGAGGTTGCAAATGTCAGTGCCTCAGAAGGACCAG
GCAAGTTCTGTAAATGATTGATGTGGATAAGGCAAAGAGGAACACAAGAATGGTGGAGACCAGGTTGAACTGCAGAACACATGCCCTCTT
TGAAGGGGTGCCCACACTCAGCTCTAGACAATCAGAACCATGCAGAAATCAGGCCCAGGGCTGCTAGATCTTCTGACGTGGAAGTATGAT
ATTACCTGACACGTAAGTGTTGACAACTAACTCAAACTCTTGGCCAACACTGTGCAGACCAAAGAGAAGCTGTACACAGACAGGTGCAGC
CTGCAGCCCCCAGTTTCAACTATTGGGAAAAGTGGATTTCACATTCCACAGTTGTCAGGTCAGGTTCATCCATCAGCCCCACAAACTCAC
ATGTCGGCACTATCTGGGCAACTAAAATAAAAGAGGGGAAAGAGATCATTTCTCCCCAGATATCATTCTCATGGCAGACTTGAATATAGA
TACGCTGAGTTATCCAGCTCTCTCACTCTGCCTCCTTTTGGCATGCCCAGGCTGTGCCCCGTAAAGTGTTGAATCACTGTTATCCTAATT
TTCTTAGTGTTTTCTACCGTGGCCACTGTGATGAGGGGCTGGCAAAGAGCAGCCTCGTGCCTTCCGAGAAGGCTGCCAGGAGCCTCTGAA
GCTTGAAGCGAGCACACATTGCCTCCTTGTGCCAAAGCCCTTGGCCAGCCTCCCCACACTCCTTCCCTCTCCATCCGGCCTCATGAGTCT
TCGTTACCAAGTAAAATTACCACTGCTTCACCTCTGATACAGCAGAAGCCTTGCTTCAGAACTGGTAGGCATTTAGGCTATTTCAGAGTG
TCCACTAACCTCAAAAGGAGGTTTTTCCACATACAAAACCCTAGCATCTTTGAGGGGAAAGCAAAATGAGAATAAATTATGTCATGAAAA
AAATTAGAAGTTGCTTCCTTCATTTAGATGGACTAAGTTATTTTAAACTCTATCTTACATCAGAGTCCTGATGGTGTTGGGATAGTCACT
GACCCTTTCACGTATGTAATAAGATACGTCTCGTTCACACACTATTTCATTTGATCTTTGTAAGAACCCAGTGTAGAATAGGAATATTTA
AAATCAACATTACCCACCTCCAAGGCCAACCCAGAGTAGTCTTGAACCTGAGTCAGCCTCAGTATTGCTTGCAAGGAAGAGGGAAGGGGC
TCATTAAAGGCCTGGCTCAAACCTTAGTCTTCCAGACTGACTAGGGACGTAAGAAGACCCAGGGACCCACCATGTTCTCAAACCATCTAT
TCAGTCCAGGCCTTTCAGCATAGACATAAAGAGCCCACCCGTTACTCAGTCATGTTGCCAAGTGCAAACTGATTTATCCCCAGATGAATC
CCTTTACTGTAGCAGATCCCTAATCCCTAAATTTCAGCCAATTTGGTAGTTAATTATAGGAGTTTATTAGCTAAATGTATGTTCTGAGTA
AAAGTTTTGACTCTTTGGGGAAAATTTATTTTGCTGCTAGCATACAACATTTGCTATGTATATAAACTTAAGTCAATGCCAGAAATTTTA
AAACCAGCTCAAATTTATAATCTGTAATGATCAAATCAAAACATACTGTAAACTCAGAGTTGGAAACGCCTGGTAATATGGTTAAGTCAT
GTTTAAATATGAATGCAATTTAAATGACATTGGCAATGCCTGAGATTTCTTTCATTGTGAATGATTAAAAGGCAGTCCAATATATGAATG
GATTTCATCTTACCTTTCTCCCGTTAATTTACTAGGTGTAACATCTTGAGTGTAAAGTCATTCACAGGCAGTTGGGTTGTGGAGCTAGAA
GGAGCCTCAAAAAAAAACTTTTTGGCCAGACTCCTACATCATGAACAGGGTTTTTGATGAATAATATTTATTATTATGTTTCTAAAGTAA
TACAGTGTTGGAGAATGAAACAGTTTAGTCCTTTCCTCTTCTGATGGAAAAGAATCATAGCGCCGTTGCCATGACAATAACAGGATGTAG
AAAGACCCATGAAGAAAGAAAGAAGAAAGCTATGGTTCCGAAAGCAGGTAACCACAGATTTTGAAAGGAGGCAGAGATGGTGATTAAACT
GTAGTCCTTGTTTTTTAAAATGTTCTTTCATGTTAGGCACCACCACATAGTTAATAACTACCAACTTCTAAAGAGAAGATCCCCTTGATT
TATTTATATCATGAAAATACTAAAAATCAATTCTCAAGTCTAATTAACTATTACATTATCTTGCTAGGTCCTTTTCCCTAAATTTTTAAT
TCAGAAAATTAACCAGAATTGGCCAGATGCAGTGGTTCACGCCTATAATCCCAGCACTTTGGGAGTCCAAGGCAGATGGATCACTTGAGG
TCAGTAGTTCAAGACCAGCCTGGCCAACAGAGGAAGAAAGAGTGAAAACAAAAGAAGAAAGAGGGAAACCCTGTCTTTACTAAAAATACA
AAAATTAGTCGGGCGTGGTGGCGCACACCTGTAATTCCAGCTACTTGAGAGGCTGAGGCAGGAGAATCCCTTGAAACTGCAGGCAGAGGT
TGCAGTGAGCCAAGATTTCACTGCTGCACCTGGGGTGAGACTACCATTAAGGAAGGAAATTTCCTTTAAACAGAAAAAAACAAAGGTGCT
CATCTATTTCTTCTGAATTCTCTCTACATCCTTGACTTAAGAGGAAAACCAGCACTCAAGAAACAGCTTTAAAAGAGAACAGTCCCCATT
CTAGCTACCAGTCTTGCTTTCCCCCATCTTGGCAAGCCCCAGTGAATTTGCCATTGAAAGATTACCCTCCCCTTTGCCCTCATCTGCCTG
AGCTAGAGGCCAGGCTGTTGTTAATGTTTTTTCAGTTCCAAAGCCCCTGATGGGACATTCTTGTTTCTGTGCTACTGCTTTCTCTCTCTT
AAATTAAGGTGCAAGGGGATAAATATTACTATAACTGGGATGTAAGGCTCAGTCAGTGTGGCTATTCCCTCCCTTCGGGGGAAATATTCC
ATCTGTCTGAACGGTTTTAGGTGATCATGAGGAGAGCGGCTTAGTCACACAGCCAGCCACGCTCATCACAAAAGATTTGTTCAGACTCAC
TGTAAAGAATGACAAGGCAGATAGCTAATCCTTTCACTGTGCCTCAAAGCCCGCCGTGCAAGTCACCAACCCTACCGGTCCTCTCCACGT
GCGAGGCTAATAGAGTGATCAGAACCAGGAATGTGAGCTGGGTTCCACCTTAGGAGGGGACAATGAGGACAGAGCAAGAGGGCTCCATGT
TTAATTACTCCAGGCTCTGACTTCTGCCCACAATTACAGAGCATGAAAGCAGAATTGGCCTTTAGTAAGTGAAAAGGAAGTGGCTCCTGC
AGCATATAATTGTTATAATTTCGTATTTATGGAAAGAGAAAAGGACTTCAGTCCACTCATGTTGTTAAGCACTTGTCCCTCACTCCACTG
GAGCCCCCTTCCTATGTTTTGGGCACAGATGGCTGGGACCGAGAGGAAAGAGGAAGAGCGGCTGCCAGAGTGTGAATATACCCCTCAGGG
ATATACAGCGGAGTTTCATGATAAACTACCCATACTTTCCCAAAAAAGGTTGAGGAGCAATACATAACTTTGCAGATTACAAACCCTTGT
TTTACTTTTTAAACCTTTTTTCCATACTCTGCTTATTGGAAATCGATGGCTGTGATGTGACCAACACCTGTGATGATAGCAAAGCCCCTC
CTTTCACAGTCTCCTGACTGTTCGGGGAACCTCCTTGGTCATTGGTAGAAAGCTTTAGAAAAGACTTAGCTTTTTAGGGAAGAACTAAAA
AATCTCCAAAACATACTAGTCCCATGACTTCGATAACTGAAAATGTCCTGGGTGTAAACTAACCCAGGAATGTGGATCATACATGTTTTT
TTTAAAAAAAATCCCTGAATCAATATTTTCCTACAACACACCCTAAAATTCCTATTTTTGTAATTAATGGTTGGACAGTGATCAGCCATT
TAAACATAGGCTTTCTGGAATAACCAGACACTAGAATAGTTTCCAAAGTGTTTTGCGTATCAAAATCCTATATACTTAGAAGAAGAACTC
AGGATAAGAAAAAATCGCTAGGTCCCAAAGGGTTCATGACTATCATCAGATGCAACTGCGAGTGGCCTACGGTCATTTTTTCAAATGAGA
AGACTGGAGAGAGAGAACAACAGTAATCACAAAACCTCTGTTGCCCTTAGTCCATGACAATGTTTAAGGAAACTTTAAAAAATTAAGCCA
TCTTCTGAATTGTTTTCTACACCAAATCTAAAATATTAAAATGAAATTATTAAATATTTAAAATGGGGTATTTAGTGGAAATGCAATCAG
TAGAAAACATTGCTTTTTAGTGCCTGCTAAACAAGTAAAGGAGAAAGAATGAAGAGAAAACAGCAGTCCTTCCTGTGTGACACTCGTGTG
GAAATGACAGGCATTCACATGTCATTGAGTGCTAACTCAAAAGCTAGGTGGCAATGCTGTCCAATGTTTAGAGATCTTTTGAAATATAAT
TTTACCACCATTCAGAGGTAAGTACTTGCTTAACAGAAGTCTTTAATGTTAGTGAATGAATGTATAAAATTATAAACTATGCATTTTCAA
AGAGTAGCATGTATTTTGTATCGAATCCAAGTAAATTTTTTTCATAGCTACCTACCACAACTGCAAATTATTCAAAATAAACTTGGATAC
ATATCCTTATGGGGATATGGGAAGCCCATCTATATTCTCCTACTTGATGTTTTTAAAGATTGAAACTTTATTCTGAAACATCAGGCTCTA
AAAAATTCCATCATTAAGATGAATAAATGGGAAATGGTTTATTTGTTACTTCGTAAGCATAAATGGGAAATGTTGGCTGTTAGAAAATGT
GCCCAGTTCTTTAAAGGTGGATGTTCTAGTAACACTGGATTAACAAGCAAACAAAACTGCATGAAGTGAACGAATATTTCATTGGATAAA
GTTAGCATAGGTTTTATCTGCTGGGTTTAATTCTCAATCCCAGAAAAAAATATTCTTCAAGGGGTATCAGTTATAGTTTCAAAGAACAAA
ATATGAAAATATTGTCCAGCAAAGCAAATCATTGATCTTTTTTCAAAATTACTTATATTTTGGAAAGTCTATATAGAATATCCACAAATT
TCTTCAGCCCTCTTGTTGATTTCATATTTTCATGAAACTTTTTCCCCTAATAATTTGTCTTCGCTCTTTAATCAGTGCTTTACTACATTA
CTCAGCCTGAAAAAATATCTTTTCCTTCATCTGACAATGTGGAAATAAAGAACTCCATTTCTGTCATTCTGGTTCTCTTCAGTGTCCATT
GAGAAAGTTTCTCAACTGTTTGTAAAATACGGGGGGAAAAAAACACGCATTTCTAAACCTGGTACTTAAGGTTATACTGGATTGTTTGCT
ACCTAATTAGAAGTTATTGGGGAAGGGGCATTGTGTCTTTTTATATGATTTTTAGCCAAATCCAGATGTTCTGATACACATTTCTGAATA
CCTGTCTGACTGTAAATACAGCCTGTGGAGGTTCAGGTTGATAAACCTTTCACCTGACTGCTCCACAGCCATGCTCCTTGCCAGCTTCTG
GCACATTGTACATAGATTTGTTGAATGTTTAAATGATGTTGTTTTTCTAAATGCTGTTCTCTAAAACAATTTTTTGAATTTCTTTTGCTT
TCCATTGTTTTGGACTTTGTGTGTTCGTTTTTTAAAAAAAAAAATGTTTCCTAAATATTTAACACCAGGAAAAATATTTTTAAATACACT
GGTGCTAATTGAAACAGAAGGAAATTTTCAGATCGAAGATGTACAATGTTAAATGTTCATACCAGTTAAACTGCACTTTCCCAAGGGGAC
AGCTGGCATCTACTTGAAATGGGCATCAAGAGACCACCAAATGTTTACAGTTTCTGTGGCCCGTTTAAGTGTAAAATGCAGAAGTGGCTC
TGTCCCCCCAGAGTTAAGGATTTGCTACACTGGTCCTCTGGAAGCATTTAAGTAGAAGAAAAGGCTTATAGTCAGAATCACTTTAGTAAT
CGTCTTCTGGTCCTTGGACTTTTCTGTTCTGTAATGCTTGTAACAATGAATATGGTGTTGCCAATCTAGTCTGATATCATTGTTGACCTG
TACTTACTTTGTGGATGGTTCTACCTGGGGTTGCACTGGCACAAACAGAGCCAGAACACTGGACTTTCAAAAGACCATTTTGACTTCTAC
AGTGTCCACACACATGAATTTAAATGCACTTGTAACTGGTTAATTACCATGAAGTAAGTCTAACTTCCACTTAATAAAAGTTTTTGTGTA

>78323_78323_1_RRM2B-ZNF704_RRM2B_chr8_103231042_ENST00000251810_ZNF704_chr8_81555364_ENST00000327835_length(amino acids)=334AA_BP=266
MGAGRTQRTSGPPGCCRSWRWPEELSSLSARSFGGVCAMGDPERPEAAGLDQDERSSSDTNESEIKSNEEPLLRKSSRRFVIFPIQYPDI
WKMYKQAQASFWTAEEVDLSKDLPHWNKLKADEKYFISHILAFFAASDGIVNENLVERFSQEVQVPEARCFYGFQILIENVHSEMYSLLI
DTYIRDPKKREFLFNAIETMPYVKKKADWALRWIADRKSTFGERVVAFAAVEGVFFSGSFAAIFWLKKRGLMPGLTFSNELISRDEVSPT

--------------------------------------------------------------
>78323_78323_2_RRM2B-ZNF704_RRM2B_chr8_103231042_ENST00000395912_ZNF704_chr8_81555364_ENST00000327835_length(transcript)=13650nt_BP=528nt
ATGGGCGACCCGGAAAGGCCGGAAGCGGCCGGGCTGGATCAGGATGAGGTCGACTTATCAAAGGATCTCCCTCACTGGAACAAGCTTAAA
GCAGATGAGAAGTACTTCATCTCTCACATCTTAGCCTTTTTTGCAGCCAGTGATGGAATTGTAAATGAAAATTTGGTGGAGCGCTTTAGT
CAGGAGGTGCAGGTTCCAGAGGCTCGCTGTTTCTATGGCTTTCAAATTCTCATCGAGAATGTTCACTCAGAGATGTACAGTTTGCTGATA
GACACTTACATCAGAGATCCCAAGAAAAGGGAATTTTTATTTAATGCAATTGAAACCATGCCCTATGTTAAGAAAAAAGCAGATTGGGCC
TTGCGATGGATAGCAGATAGAAAATCTACTTTTGGGGAAAGAGTGGTGGCCTTTGCTGCTGTAGAAGGAGTTTTCTTCTCAGGATCTTTT
GCTGCTATATTCTGGCTAAAGAAGAGAGGTCTTATGCCAGGACTCACTTTTTCCAATGAACTCATCAGCAGAGATGAAGTGTCACCCACA
CATCATCCGGTGGGCACAGGAGAGCAGAGACAGCATGCGCACACGGTCCTGTCCTCCCCACCCAGAGGCACAGTCAGCTTAAGGAAGCCC
AGGGGAGAGGGCAAAAAGTGTCGGAAGGTGTACGGGATGGAGAACCGAGACATGTGGTGTACCGCCTGCCGCTGGAAGAAGGCCTGCCAG
AGGTTCCTCGACTGAGAGACCCCCAGGCAGAGGGGCTCAGGGCCCTGAGCCGCTCCTGCCCTGGCCTGCCACTGCAGGTGTTGGAAAGAG
CTTTTCCTACTGAATAAAACACAGTTGAAGCCAGGAAAAGCCCTTTCAGGAACCTTGGAGGAATAACAGCAAAAACACAGAAAAATTGTT
TAAGTCACCACCTATGACAAAAGAAAGTTGCTCTTACTGAGAACCCAGCTTGGAGCAGCTATAACTAGTTTTTTTTCCTTCAAAAGAAAA
GTCAACTTTTTTTGCTGTATGTCTAGACTTAAAACTGTGGACTTCTGTAGCAATTGAACCAACAAAGCCCATTTTACCTAGAAAGGAGGC
ATATTTTGATAAGCTTTCTGAATTATGCCATTTTCAAGATTTTTTTGACACTTAAAAAACAAGCTACAGGTTATTCAGTAGCATTTGTAC
AAAGATCAATACTTACTTTTGTTGTGAATAATCTTTTCCGTATCTTCCATTTGACTTCTTGGAGCAGTATATGTCAGGATGTGTTGCAAG
ACAGCGCAGCACTCTGGGCATCTTTTCTATGGCTTTTTGTTTGTTTTTCTTTTAAGAATGGCCCCACACTGAACCATGGTAGAGCTATTA
GTTTGTAGGGCCCCAGATGGCATAAACTCGAGAAGGGATTGTCCACGGAAATCACCAGCAGACTTCAGCCCGAAGCTGAGTTCAGGAAGT
CCAGCTGTCACTGTTGGGAAACATCTAGGAGTCTTCCTTGGATCCATAAGAAGCTCTTCCCCTAAAGGCAGCACAGCTAACTCTACTCTC
TACCTGCCACAACTCAGTCAAGAATTGGCACCTGTAGCCATCTGGGTAAGCCTCGATGCTTCTTTCAGGGATGTGACACAAATGGCAACT
CGGAGCTATTTGTTACTGCTTGTCTGTCAAGATTGTAGCCAGGTTAATGGGTCATTTTCCTTCTCTCCAGACTCCACCACTGACTGATTT
CAGAAGAGGTAGAGAACTCCAAACTGTCCCAGCAGGTTTGCTTTAGACAACAGAGCACAGCCCACATGGCCCTACCTGTTCAGAAAGTCA
TGTTAGATCAACAAACCACTTCCATTCTGAGTGCACTTTTATAGGTTTTATGCTTTAGCATGTCCGGGAGATGAGTTAATTAACAATATA
AACATTATGTGAGTAAATGGAAGGTCCAAACTTTAAGTTTTTCTTATAAAAATATTGGAGCTATTCATTTAAGAATTTGCTCAAAAGGGA
ACATAACGCCAAAAGGAAAATGCATGTAGGTATAGGAATTTCTCAGTTTAGTAGGGCCAGGGCTTGCACTATGTTCCATTTATTGGGCTT
CGTAACTTACTTGCTTGTTTGTTTGGGGGATAGTGGTGTGGGGAGAGGGGAGTCGTCAAGCCCTATAAATAAGCTCATTCTCTATCTACC
CGACTCTCAATTGCCCTGCTAAAGAGTTATTTCTCCTATACCTATGCAAAGTAGGAAGAGCACCTTATAGGAGGCACTGTATAGGGACAG
GGGACATGGGATCAGCCATAGGAATGTTAAATGAAATTGCACAGAGGAAAGTTTAATATATGTCTAGAGATTATACATACACTTTTTTAA
GCGTAAAAAGAAGACATCTAGTAATGACAGATATTCTTTTTATATACAAGCAAAAGAAAGTATAAGGAGGTTCTACAGTGCAACATCCAC
AATCTGTGCATTCACATATTATGGGACTTTTATTTTTTAAACTCTCATATAAATTTTTTAAAATTACTCCTTGGAAGAGATCCTGGTTTT
TTTCTTCATTTATTTTTTTCTTTAAAAACATTTATTTTAAGAGAAGAGAAAAAGAGCTTCATCTAATTTTGCATCTTGATTACCAATCAG
TACTAGTCACAGCACCAGCAATACTGTATGTTTTAGACTGACAAGGTCAGCCAGGAAATGGCATTTTTTTAAACGCAGAAATGTGTTTGT
TTCCTCTACTCTAACACGTCCTTTCTCCTCCTGGTGTCCTGTCACCCCCCATGCAGCACCACTGATGCGAGATGATGCTCTGGCCTGGTC
CAGGAAGCCCTGAGCCATGGGCAGATTGCCCAGTGGCCTTGGGCGGCCAGAGCTTGTCACCTGTTTAAACAAGTTCACCATGTGTTTAAA
TGACAGGGTACAGTCCTGGACCAGAGGTTTTTCTCTTCAGCAAAGCTCCCTGGCCCTTGATCGTTGGACTGTTACTAATAGAAAAAGATT
CAAGTCATGAAGTATAAAATCCATCCCCCATCCCAGAACTTTGAAACACAAGGAGGGAGAGATCTTTGCTATGGAGCAGTCCTGGAGCAA
AGCCCCGTGGCTTCCACCCCCAGATATATACCCCATAAGTAGTGCTGAGCTCCAGCTTAGCTGAGCCAAGCTCAGTCCTTATCTGGTGTT
CAGCCAGTGCACAGGTATAAGCAGAACTACAGAGCTGAATGTAGCTTCCCTGGGATCTCTTCTCCTTTCTAAAGCATTTTTCACACAGTT
CTGTACCTCCTACCCAAGTTGGGGCTGCTTTCTGCCTGCTAGCCCACGGCTCTGTGTACTTTCTTTTCTGGCTTCAGGTGCAGACAGACC
CTCAGTACCTTCCTGGACACAGACACATATTCCCTGGACCAAGGCGTGGAATAACTAGTAGACCACCAAGCCACAGGTGGCTGGTCTTGA
AGAAAAGGGATTATACTCCTTACAGGCCACCCAGAAAGCTATGAATTCCAATATACACCACTGATCGTGCAAGTTAGGGTTTTTTTTTTT
TAAACGTAGCATTATTTTGTTATATTTTGGAACTAAATGAAGTGCCAAATTAACCAGACATTCGTTTGATGCCATCTCTGTGGAACCAAG
TTCTCTGTGTGTGTTCGTTTGGCTGGGAGGAGGGGGAGGACTGGGCAGACTGCTCCCACAGCAGGCTGGCAGTGGAACTGGAGCCCTGGC
CACCGCAGGGAGCTCAGAGGCCAATCTACGCAAAAGGCATGCAAAACAATGGATTCTGGTCCCAAAATATTTCTAAGTAAGGCATGATGT
AGCCTTTTGATTTTTTTTTTATCCTTTGACACCCCAGCCTTCAGAAAAGGTTTTTCATCTCTCTCCAAAGAAGTCATTTCATAGTGACTG
ACAGGACATTCTCCAGAGAGCGACAAAGCAGAGTGGCCAGCAGGCAGTGGTGTTAAGCCTTGGGCCTTCCCAGCAGATGTGTGCTGCATT
GGTGGGTGGGAGGCAGTGTGACAGCCTGGAGAAAACACACAGGTAGCAAGGGAGTCAGGGGGGAGGTACAAGAGGGCTGTGGACACCTGG
CTCTTGCTCATCTTCTTGGTGCTGATCAGCTGGTGGTCACCATCCCTAAGTACCTCCCAGGGAGCTGCCATTTTCTCCTCTGGGAGCAGC
TGCCTGAAGCAAGGAGAGAATGACCTGAAGGGAAGTACCTCCGGCCAAGAGTGCAGGGCTGCTGTGCCTAGCCTGAGCGGGCCATCTCTA
GCAGATATGGACTTCTCTCCACCACACTAGCTGAAAAGTTTTCTCCCTTGGTTGGCAAAAGCCAGTGTCAGGAAAAAAGCTGTGGGTTTC
TGACCAAGAATGTGTGCGCTTAGCTGCAAAGTGCCTGTCAGCAGCTCCAGGCACCAACAAGGTGCCCTTTTATTAGACAATTCCTGCCCG
AACATAACCATATTGCAGATGAAAATTTTCAATAGAGAATGACACAATTCTTGACCTTTCTAAAAACTTTTCAAAGAGATAGTCACATGT
GTATATGTTGCAAAAGATTTTTGAAACTGAAATGTCCTCCATTAAATCTCAAGAGCACTCGAGTTTTAAGTCTGCTGTTTCTGGTGTCAC
ACTAAGACACACTTTTGAAAGCAGCCCTGGGTTCTGAATTAGTTGGCACTGCTGAATCCATGTTCCCCCTTCATCAGACTCCAAAGTGCA
GCATTCACTTGCAAAGGTTGAGAGAAAAGTGGCCAGAATTGTACATATAACAGAGAATACCTTGAGAATAGTAGCAAAATACTGTAAATA
ATATTCATTTCCTCAGGGAAAAATAAAGGGCATGCAAAAATAGGTCTGGAGACTCCTGAAACTAGGAAGAATTTTGTTATCACTAAAGTC
TTTTATAGTCAGAACAATTTTTTTTTCAAATGAACATGGTATCATTTCAAGACAAATTTATGTGAACTGGGCAGTACTGACATTTGTGAG
GCATAGGGGAGTGCCCTGGGAAAACGGTTTGGAGCTGACCTGTAGCCTAAGGCTAACATTTGAACCACAGGTGCAATGCCTGGGGGTGGG
GGAGGGGGACGGGGTGGGGGTGGTATTCCTAGACTCACGTAAGGCTTTTTCTGAATGTAATTGTGAATACAAAGCCTTGCTGGTCCTTTT
TATCATTACCCAATGGATGACTGTTTATTAGCTATCAGCAGAATTCCGTAGGCGAAAGCAAGCCGTGAACGATGTACATTTTGCTTTAAT
AGCATGTTAGCGAACAAACTTCCATGGACTTTTGTGGACAAGGTGCTGCTTTTTCTCATGACCCTGTAGAATTGCTATCGACCACATCTT
CTGTAGCACTGACCTGTGTGAACTCAGGGAAGAATTTGTGCATACAAATGAGTGGAAACAGAGCAGGATTCATGAATATGAATGAGAATG
TGAATCATTTTGGAGAATGCCCTGGGCACACGGGTCAACTGGAAATTTCATTTCTCTAAGAAAGTAGCCCTACCAGCGGCACGGACTGTT
CCTGTTCCTCATACCTGTGGGGATTCCTCCATATTGGAACTGTTTCATGTATCTTTTTTGCATTGTAACTAGCCAAACCTGAAGTCAGTA
AATAAAATGAGATTAGCACTTTTTTTAGGTACCAGTTGTATCACTGAGTAATGCACACCAATAGAGCAAGAAAGTATAAAATGTATTTAA
GACCAACTGGTTTGCTTATTATGACTGACTTTGAAAAAGCCCATATCCAATGATATACATGCTTTAAAAGGTATATCTATCGTAGGACCA
GGAACCAAAATGGGAATTTTACTTCTGGTCCTGTTTTGTAAATAGTTCCTTTTTTTGAAGACAATCTCATGTTTTATAACTTTTGTTGTG
GGTCTGAGAATCACAATGGTAATATGTCTTGGCAAAACATAACCTTTAAATACAAAAACAATTATAACTTAATTTTCCAAATAAAACAAG
AAATACACTGATTAGGCTTCTACAGTTCTAAGAGACATGACACTTTGGTAATAAGCGTCAGTACTCTACTTCTCAAGTTAACTGGAAATA
TTTTACAAGATGCAGTGTTTTGTAATCACAAAGAACGCAGACATTTTGTGAGAAATGACCTTGGTTTTATACATTGTAGCTTATTTTTTA
AAATATAGTATTTTACCAGGCAGGAAGTATTAATATTATAAGTAATTCTTGCTCACCAAACAAAGGGCTATGTCTCTTTTAAGCAAATGT
TTTGATGCATATCTTTTTAATTAACCCTCTGCAGCAAGGGTAGAAATACAGATCAGATGGAATGGGTATTATAGGAGAATCAAGATAGCA
ACAGCTACTCCTTTTACCATTACTAGTGTGTTTTCAAAGTATGGAAAAAGATGCCTGAAGAGTCATTTTATATATTTTAAATCTAAAAAG
TGTTAACAGGTATGCTTATAGGCCATGGGAGAAATATTCTTATAAATTTTTTAGTGTAAAATGATAAATTCTGTGTCACAAAGACAAGTT
TACCACTTGACCTACCAGAATCACAGATACTTGCATTTAACTAGCAAGTATCATTTGGTGGAAATTTCTAAAATCATAGTAGACAGGCCC
AAAGATAGAATTCTTAGGTGATCAGTAGTGTTTAAAATAATTTTGTCCTCAGCACTAACTATATAACTGTAATTTCTACATAAGAACAAG
TGCTTCCAAAATATAGTGGAGGGAAAAAATAAAAAAGGAAAATAAAAAAACAAAACAAAAAGAACAAGTGCTTGATTTTTCACTGTGAAG
AACTAGCAGGCACATGAGGTTGTGATCAGAAAGTGACTGAGTTCCCAAGAACCAGGAAACAGAGGGGAGTTGTGAAGAGTTTATTAAAAC
TGTACAAATAATTCAGAGCTTTGCCAAAACCATTTCATAATGCTGTACAGTTTTTTCAAGCCCACTCACTGTTAAAACAAGAAAGCACCT
TTTCTTTCTAAGATTTTAGTAATCCAAAAGCTAGCCTAATTAGCCAAGTATGCAGATAACATCAAAAGCAAAGCTGAGATAGAACAGCCA
TACACCCGTTGGGCAGCTCTTATGAGGTGGTCAGAAGGTCACTCAGACCTTGGTTTCAAATAGGCTTTAGAATCTGCACACTTGAGGACT
AGAAATGCACAGAGTTAGGGAAAGCCATGTACAGGCTTGGCTCCTAGTCTTTGAGATGAGGCGTCTTGCAAATCTCTGTTTTCACTCCTT
GGAATGTCTCCATTGTTAGCATTAAAGTCCCCAAGAAGTTTTTATTGCTGTACGGTTTTGAACCCAATGAGTCTCATTTCCAAAAGATTC
CTAATTCTATATAGGAGAGGTTGCAAATGTCAGTGCCTCAGAAGGACCAGGCAAGTTCTGTAAATGATTGATGTGGATAAGGCAAAGAGG
AACACAAGAATGGTGGAGACCAGGTTGAACTGCAGAACACATGCCCTCTTTGAAGGGGTGCCCACACTCAGCTCTAGACAATCAGAACCA
TGCAGAAATCAGGCCCAGGGCTGCTAGATCTTCTGACGTGGAAGTATGATATTACCTGACACGTAAGTGTTGACAACTAACTCAAACTCT
TGGCCAACACTGTGCAGACCAAAGAGAAGCTGTACACAGACAGGTGCAGCCTGCAGCCCCCAGTTTCAACTATTGGGAAAAGTGGATTTC
ACATTCCACAGTTGTCAGGTCAGGTTCATCCATCAGCCCCACAAACTCACATGTCGGCACTATCTGGGCAACTAAAATAAAAGAGGGGAA
AGAGATCATTTCTCCCCAGATATCATTCTCATGGCAGACTTGAATATAGATACGCTGAGTTATCCAGCTCTCTCACTCTGCCTCCTTTTG
GCATGCCCAGGCTGTGCCCCGTAAAGTGTTGAATCACTGTTATCCTAATTTTCTTAGTGTTTTCTACCGTGGCCACTGTGATGAGGGGCT
GGCAAAGAGCAGCCTCGTGCCTTCCGAGAAGGCTGCCAGGAGCCTCTGAAGCTTGAAGCGAGCACACATTGCCTCCTTGTGCCAAAGCCC
TTGGCCAGCCTCCCCACACTCCTTCCCTCTCCATCCGGCCTCATGAGTCTTCGTTACCAAGTAAAATTACCACTGCTTCACCTCTGATAC
AGCAGAAGCCTTGCTTCAGAACTGGTAGGCATTTAGGCTATTTCAGAGTGTCCACTAACCTCAAAAGGAGGTTTTTCCACATACAAAACC
CTAGCATCTTTGAGGGGAAAGCAAAATGAGAATAAATTATGTCATGAAAAAAATTAGAAGTTGCTTCCTTCATTTAGATGGACTAAGTTA
TTTTAAACTCTATCTTACATCAGAGTCCTGATGGTGTTGGGATAGTCACTGACCCTTTCACGTATGTAATAAGATACGTCTCGTTCACAC
ACTATTTCATTTGATCTTTGTAAGAACCCAGTGTAGAATAGGAATATTTAAAATCAACATTACCCACCTCCAAGGCCAACCCAGAGTAGT
CTTGAACCTGAGTCAGCCTCAGTATTGCTTGCAAGGAAGAGGGAAGGGGCTCATTAAAGGCCTGGCTCAAACCTTAGTCTTCCAGACTGA
CTAGGGACGTAAGAAGACCCAGGGACCCACCATGTTCTCAAACCATCTATTCAGTCCAGGCCTTTCAGCATAGACATAAAGAGCCCACCC
GTTACTCAGTCATGTTGCCAAGTGCAAACTGATTTATCCCCAGATGAATCCCTTTACTGTAGCAGATCCCTAATCCCTAAATTTCAGCCA
ATTTGGTAGTTAATTATAGGAGTTTATTAGCTAAATGTATGTTCTGAGTAAAAGTTTTGACTCTTTGGGGAAAATTTATTTTGCTGCTAG
CATACAACATTTGCTATGTATATAAACTTAAGTCAATGCCAGAAATTTTAAAACCAGCTCAAATTTATAATCTGTAATGATCAAATCAAA
ACATACTGTAAACTCAGAGTTGGAAACGCCTGGTAATATGGTTAAGTCATGTTTAAATATGAATGCAATTTAAATGACATTGGCAATGCC
TGAGATTTCTTTCATTGTGAATGATTAAAAGGCAGTCCAATATATGAATGGATTTCATCTTACCTTTCTCCCGTTAATTTACTAGGTGTA
ACATCTTGAGTGTAAAGTCATTCACAGGCAGTTGGGTTGTGGAGCTAGAAGGAGCCTCAAAAAAAAACTTTTTGGCCAGACTCCTACATC
ATGAACAGGGTTTTTGATGAATAATATTTATTATTATGTTTCTAAAGTAATACAGTGTTGGAGAATGAAACAGTTTAGTCCTTTCCTCTT
CTGATGGAAAAGAATCATAGCGCCGTTGCCATGACAATAACAGGATGTAGAAAGACCCATGAAGAAAGAAAGAAGAAAGCTATGGTTCCG
AAAGCAGGTAACCACAGATTTTGAAAGGAGGCAGAGATGGTGATTAAACTGTAGTCCTTGTTTTTTAAAATGTTCTTTCATGTTAGGCAC
CACCACATAGTTAATAACTACCAACTTCTAAAGAGAAGATCCCCTTGATTTATTTATATCATGAAAATACTAAAAATCAATTCTCAAGTC
TAATTAACTATTACATTATCTTGCTAGGTCCTTTTCCCTAAATTTTTAATTCAGAAAATTAACCAGAATTGGCCAGATGCAGTGGTTCAC
GCCTATAATCCCAGCACTTTGGGAGTCCAAGGCAGATGGATCACTTGAGGTCAGTAGTTCAAGACCAGCCTGGCCAACAGAGGAAGAAAG
AGTGAAAACAAAAGAAGAAAGAGGGAAACCCTGTCTTTACTAAAAATACAAAAATTAGTCGGGCGTGGTGGCGCACACCTGTAATTCCAG
CTACTTGAGAGGCTGAGGCAGGAGAATCCCTTGAAACTGCAGGCAGAGGTTGCAGTGAGCCAAGATTTCACTGCTGCACCTGGGGTGAGA
CTACCATTAAGGAAGGAAATTTCCTTTAAACAGAAAAAAACAAAGGTGCTCATCTATTTCTTCTGAATTCTCTCTACATCCTTGACTTAA
GAGGAAAACCAGCACTCAAGAAACAGCTTTAAAAGAGAACAGTCCCCATTCTAGCTACCAGTCTTGCTTTCCCCCATCTTGGCAAGCCCC
AGTGAATTTGCCATTGAAAGATTACCCTCCCCTTTGCCCTCATCTGCCTGAGCTAGAGGCCAGGCTGTTGTTAATGTTTTTTCAGTTCCA
AAGCCCCTGATGGGACATTCTTGTTTCTGTGCTACTGCTTTCTCTCTCTTAAATTAAGGTGCAAGGGGATAAATATTACTATAACTGGGA
TGTAAGGCTCAGTCAGTGTGGCTATTCCCTCCCTTCGGGGGAAATATTCCATCTGTCTGAACGGTTTTAGGTGATCATGAGGAGAGCGGC
TTAGTCACACAGCCAGCCACGCTCATCACAAAAGATTTGTTCAGACTCACTGTAAAGAATGACAAGGCAGATAGCTAATCCTTTCACTGT
GCCTCAAAGCCCGCCGTGCAAGTCACCAACCCTACCGGTCCTCTCCACGTGCGAGGCTAATAGAGTGATCAGAACCAGGAATGTGAGCTG
GGTTCCACCTTAGGAGGGGACAATGAGGACAGAGCAAGAGGGCTCCATGTTTAATTACTCCAGGCTCTGACTTCTGCCCACAATTACAGA
GCATGAAAGCAGAATTGGCCTTTAGTAAGTGAAAAGGAAGTGGCTCCTGCAGCATATAATTGTTATAATTTCGTATTTATGGAAAGAGAA
AAGGACTTCAGTCCACTCATGTTGTTAAGCACTTGTCCCTCACTCCACTGGAGCCCCCTTCCTATGTTTTGGGCACAGATGGCTGGGACC
GAGAGGAAAGAGGAAGAGCGGCTGCCAGAGTGTGAATATACCCCTCAGGGATATACAGCGGAGTTTCATGATAAACTACCCATACTTTCC
CAAAAAAGGTTGAGGAGCAATACATAACTTTGCAGATTACAAACCCTTGTTTTACTTTTTAAACCTTTTTTCCATACTCTGCTTATTGGA
AATCGATGGCTGTGATGTGACCAACACCTGTGATGATAGCAAAGCCCCTCCTTTCACAGTCTCCTGACTGTTCGGGGAACCTCCTTGGTC
ATTGGTAGAAAGCTTTAGAAAAGACTTAGCTTTTTAGGGAAGAACTAAAAAATCTCCAAAACATACTAGTCCCATGACTTCGATAACTGA
AAATGTCCTGGGTGTAAACTAACCCAGGAATGTGGATCATACATGTTTTTTTTAAAAAAAATCCCTGAATCAATATTTTCCTACAACACA
CCCTAAAATTCCTATTTTTGTAATTAATGGTTGGACAGTGATCAGCCATTTAAACATAGGCTTTCTGGAATAACCAGACACTAGAATAGT
TTCCAAAGTGTTTTGCGTATCAAAATCCTATATACTTAGAAGAAGAACTCAGGATAAGAAAAAATCGCTAGGTCCCAAAGGGTTCATGAC
TATCATCAGATGCAACTGCGAGTGGCCTACGGTCATTTTTTCAAATGAGAAGACTGGAGAGAGAGAACAACAGTAATCACAAAACCTCTG
TTGCCCTTAGTCCATGACAATGTTTAAGGAAACTTTAAAAAATTAAGCCATCTTCTGAATTGTTTTCTACACCAAATCTAAAATATTAAA
ATGAAATTATTAAATATTTAAAATGGGGTATTTAGTGGAAATGCAATCAGTAGAAAACATTGCTTTTTAGTGCCTGCTAAACAAGTAAAG
GAGAAAGAATGAAGAGAAAACAGCAGTCCTTCCTGTGTGACACTCGTGTGGAAATGACAGGCATTCACATGTCATTGAGTGCTAACTCAA
AAGCTAGGTGGCAATGCTGTCCAATGTTTAGAGATCTTTTGAAATATAATTTTACCACCATTCAGAGGTAAGTACTTGCTTAACAGAAGT
CTTTAATGTTAGTGAATGAATGTATAAAATTATAAACTATGCATTTTCAAAGAGTAGCATGTATTTTGTATCGAATCCAAGTAAATTTTT
TTCATAGCTACCTACCACAACTGCAAATTATTCAAAATAAACTTGGATACATATCCTTATGGGGATATGGGAAGCCCATCTATATTCTCC
TACTTGATGTTTTTAAAGATTGAAACTTTATTCTGAAACATCAGGCTCTAAAAAATTCCATCATTAAGATGAATAAATGGGAAATGGTTT
ATTTGTTACTTCGTAAGCATAAATGGGAAATGTTGGCTGTTAGAAAATGTGCCCAGTTCTTTAAAGGTGGATGTTCTAGTAACACTGGAT
TAACAAGCAAACAAAACTGCATGAAGTGAACGAATATTTCATTGGATAAAGTTAGCATAGGTTTTATCTGCTGGGTTTAATTCTCAATCC
CAGAAAAAAATATTCTTCAAGGGGTATCAGTTATAGTTTCAAAGAACAAAATATGAAAATATTGTCCAGCAAAGCAAATCATTGATCTTT
TTTCAAAATTACTTATATTTTGGAAAGTCTATATAGAATATCCACAAATTTCTTCAGCCCTCTTGTTGATTTCATATTTTCATGAAACTT
TTTCCCCTAATAATTTGTCTTCGCTCTTTAATCAGTGCTTTACTACATTACTCAGCCTGAAAAAATATCTTTTCCTTCATCTGACAATGT
GGAAATAAAGAACTCCATTTCTGTCATTCTGGTTCTCTTCAGTGTCCATTGAGAAAGTTTCTCAACTGTTTGTAAAATACGGGGGGAAAA
AAACACGCATTTCTAAACCTGGTACTTAAGGTTATACTGGATTGTTTGCTACCTAATTAGAAGTTATTGGGGAAGGGGCATTGTGTCTTT
TTATATGATTTTTAGCCAAATCCAGATGTTCTGATACACATTTCTGAATACCTGTCTGACTGTAAATACAGCCTGTGGAGGTTCAGGTTG
ATAAACCTTTCACCTGACTGCTCCACAGCCATGCTCCTTGCCAGCTTCTGGCACATTGTACATAGATTTGTTGAATGTTTAAATGATGTT
GTTTTTCTAAATGCTGTTCTCTAAAACAATTTTTTGAATTTCTTTTGCTTTCCATTGTTTTGGACTTTGTGTGTTCGTTTTTTAAAAAAA
AAAATGTTTCCTAAATATTTAACACCAGGAAAAATATTTTTAAATACACTGGTGCTAATTGAAACAGAAGGAAATTTTCAGATCGAAGAT
GTACAATGTTAAATGTTCATACCAGTTAAACTGCACTTTCCCAAGGGGACAGCTGGCATCTACTTGAAATGGGCATCAAGAGACCACCAA
ATGTTTACAGTTTCTGTGGCCCGTTTAAGTGTAAAATGCAGAAGTGGCTCTGTCCCCCCAGAGTTAAGGATTTGCTACACTGGTCCTCTG
GAAGCATTTAAGTAGAAGAAAAGGCTTATAGTCAGAATCACTTTAGTAATCGTCTTCTGGTCCTTGGACTTTTCTGTTCTGTAATGCTTG
TAACAATGAATATGGTGTTGCCAATCTAGTCTGATATCATTGTTGACCTGTACTTACTTTGTGGATGGTTCTACCTGGGGTTGCACTGGC
ACAAACAGAGCCAGAACACTGGACTTTCAAAAGACCATTTTGACTTCTACAGTGTCCACACACATGAATTTAAATGCACTTGTAACTGGT

>78323_78323_2_RRM2B-ZNF704_RRM2B_chr8_103231042_ENST00000395912_ZNF704_chr8_81555364_ENST00000327835_length(amino acids)=244AA_BP=176
MGDPERPEAAGLDQDEVDLSKDLPHWNKLKADEKYFISHILAFFAASDGIVNENLVERFSQEVQVPEARCFYGFQILIENVHSEMYSLLI
DTYIRDPKKREFLFNAIETMPYVKKKADWALRWIADRKSTFGERVVAFAAVEGVFFSGSFAAIFWLKKRGLMPGLTFSNELISRDEVSPT

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for RRM2B-ZNF704


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for RRM2B-ZNF704


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for RRM2B-ZNF704


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource