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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:RRP15-HYOU1 (FusionGDB2 ID:78349)

Fusion Gene Summary for RRP15-HYOU1

check button Fusion gene summary
Fusion gene informationFusion gene name: RRP15-HYOU1
Fusion gene ID: 78349
HgeneTgene
Gene symbol

RRP15

HYOU1

Gene ID

51018

10525

Gene nameribosomal RNA processing 15 homologhypoxia up-regulated 1
SynonymsCGI-115|KIAA0507GRP-170|Grp170|HSP12A|IMD59|ORP-150|ORP150
Cytomap

1q41

11q23.3

Type of geneprotein-codingprotein-coding
DescriptionRRP15-like proteinribosomal RNA-processing protein 15hypoxia up-regulated protein 1150 kDa oxygen-regulated protein170 kDa glucose-regulated proteinepididymis secretory sperm binding proteinoxygen regulated protein (150kD)
Modification date2020031320200313
UniProtAcc.

Q9Y4L1

Ensembl transtripts involved in fusion geneENST00000491428, ENST00000366932, 
ENST00000404233, ENST00000525859, 
ENST00000529972, ENST00000543287, 
Fusion gene scores* DoF score3 X 2 X 2=128 X 12 X 3=288
# samples 311
** MAII scorelog2(3/12*10)=1.32192809488736
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(11/288*10)=-1.38856528791765
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: RRP15 [Title/Abstract] AND HYOU1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointRRP15(218475901)-HYOU1(118923144), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneHYOU1

GO:0006888

ER to Golgi vesicle-mediated transport

10837345

TgeneHYOU1

GO:0071456

cellular response to hypoxia

10837345

TgeneHYOU1

GO:1903298

negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway

10037731


check buttonFusion gene breakpoints across RRP15 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across HYOU1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/ABP245517RRP15chr1

218475901

+HYOU1chr11

118923144

-


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Fusion Gene ORF analysis for RRP15-HYOU1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000491428ENST00000404233RRP15chr1

218475901

+HYOU1chr11

118923144

-
3UTR-3CDSENST00000491428ENST00000525859RRP15chr1

218475901

+HYOU1chr11

118923144

-
3UTR-3CDSENST00000491428ENST00000529972RRP15chr1

218475901

+HYOU1chr11

118923144

-
3UTR-3CDSENST00000491428ENST00000543287RRP15chr1

218475901

+HYOU1chr11

118923144

-
In-frameENST00000366932ENST00000404233RRP15chr1

218475901

+HYOU1chr11

118923144

-
In-frameENST00000366932ENST00000525859RRP15chr1

218475901

+HYOU1chr11

118923144

-
In-frameENST00000366932ENST00000529972RRP15chr1

218475901

+HYOU1chr11

118923144

-
In-frameENST00000366932ENST00000543287RRP15chr1

218475901

+HYOU1chr11

118923144

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000366932RRP15chr1218475901+ENST00000404233HYOU1chr11118923144-3853435302447805
ENST00000366932RRP15chr1218475901+ENST00000529972HYOU1chr11118923144-3664435302261743
ENST00000366932RRP15chr1218475901+ENST00000525859HYOU1chr11118923144-2544435302261743
ENST00000366932RRP15chr1218475901+ENST00000543287HYOU1chr11118923144-1879435301388452

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000366932ENST00000404233RRP15chr1218475901+HYOU1chr11118923144-0.001975930.9980241
ENST00000366932ENST00000529972RRP15chr1218475901+HYOU1chr11118923144-0.00218840.9978116
ENST00000366932ENST00000525859RRP15chr1218475901+HYOU1chr11118923144-0.002852320.99714774
ENST00000366932ENST00000543287RRP15chr1218475901+HYOU1chr11118923144-0.0017758960.9982241

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Fusion Genomic Features for RRP15-HYOU1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for RRP15-HYOU1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:218475901/chr11:118923144)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.HYOU1

Q9Y4L1

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Has a pivotal role in cytoprotective cellular mechanisms triggered by oxygen deprivation. May play a role as a molecular chaperone and participate in protein folding. {ECO:0000269|PubMed:10037731}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneHYOU1chr1:218475901chr11:118923144ENST00000404233826603_6063291000.0Compositional biasNote=Poly-Glu
TgeneHYOU1chr1:218475901chr11:118923144ENST00000404233826636_6413291000.0Compositional biasNote=Poly-Pro
TgeneHYOU1chr1:218475901chr11:118923144ENST00000404233826996_9993291000.0MotifPrevents secretion from ER

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneRRP15chr1:218475901chr11:118923144ENST00000366932+25108_144135283.0Coiled coilOntology_term=ECO:0000255


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Fusion Gene Sequence for RRP15-HYOU1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>78349_78349_1_RRP15-HYOU1_RRP15_chr1_218475901_ENST00000366932_HYOU1_chr11_118923144_ENST00000404233_length(transcript)=3853nt_BP=435nt
ACTGTCAGGTGACGCTTCCGGCGCAGAAAAATGGCAGCCGCCGCTCCGGACTCACGTGTGAGTGAGGAAGAAAACCTGAAAAAGACCCCA
AAGAAGAAGATGAAAATGGTAACTGGAGCCGTAGCGTCGGTGCTGGAAGACGAGGCCACAGACACTTCTGATAGTGAAGGAAGCTGTGGA
TCGGAAAAGGACCACTTTTATTCTGATGATGACGCAATAGAAGCTGACAGTGAGGGTGATGCTGAGCCCTGTGACAAAGAAAATGAAAAT
GATGGAGAATCAAGTGTTGGGACTAATATGGGCTGGGCAGATGCTATGGCTAAAGTCCTCAACAAGAAAACTCCTGAAAGTAAACCTACT
ATTCTGGTCAAAAATAAGAAGCTGGAAAAGGAAAAAGAAAAGTTAAAGCAAGAAAGACTAGAGAAAATAAAACAGATTGAAGGCCTGATG
GATGATGTGGACTTCAAGGCAAAAGTGACTCGTGTGGAATTTGAGGAGTTGTGTGCAGACTTGTTTGAGCGGGTGCCTGGGCCTGTACAG
CAGGCCCTCCAGAGTGCCGAAATGAGTCTGGATGAGATTGAGCAGGTGATCCTGGTGGGTGGGGCCACTCGGGTCCCCAGAGTTCAGGAG
GTGCTGCTGAAGGCCGTGGGCAAGGAGGAGCTGGGGAAGAACATCAATGCAGATGAAGCAGCCGCCATGGGGGCAGTGTACCAGGCAGCT
GCGCTCAGCAAAGCCTTTAAAGTGAAGCCATTTGTCGTCCGAGATGCAGTGGTCTACCCCATCCTGGTGGAGTTCACGAGGGAGGTGGAG
GAGGAGCCTGGGATTCACAGCCTGAAGCACAATAAACGGGTACTCTTCTCTCGGATGGGGCCCTACCCTCAACGCAAAGTCATCACCTTT
AACCGCTACAGCCATGATTTCAACTTCCACATCAACTACGGCGACCTGGGCTTCCTGGGGCCTGAAGATCTTCGGGTATTTGGCTCCCAG
AATCTGACCACAGTGAAGCTAAAAGGGGTGGGTGACAGCTTCAAGAAGTATCCTGACTACGAGTCCAAGGGCATCAAGGCTCACTTCAAC
CTGGATGAGAGTGGCGTGCTCAGTCTAGACAGGGTGGAGTCTGTATTTGAGACACTGGTAGAGGACAGCGCAGAAGAGGAATCTACTCTC
ACCAAACTTGGCAACACCATTTCCAGCCTGTTTGGAGGCGGTACCACACCAGATGCCAAGGAGAATGGTACTGATACTGTCCAGGAGGAA
GAGGAGAGCCCTGCAGAGGGGAGCAAGGACGAGCCTGGGGAGCAGGTGGAGCTCAAGGAGGAAGCTGAGGCCCCAGTGGAGGATGGCTCT
CAGCCCCCACCCCCTGAACCTAAGGGAGATGCAACCCCTGAGGGAGAAAAGGCCACAGAAAAAGAAAATGGGGACAAGTCTGAGGCCCAG
AAACCAAGTGAGAAGGCAGAGGCAGGGCCTGAGGGCGTCGCTCCAGCCCCAGAGGGAGAGAAGAAGCAGAAGCCCGCCAGGAAGCGGCGA
ATGGTAGAGGAGATCGGGGTGGAGCTGGTTGTTCTGGACCTGCCTGACTTGCCAGAGGATAAGCTGGCTCAGTCGGTGCAGAAACTTCAG
GACTTGACACTCCGAGACCTGGAGAAGCAGGAACGGGAAAAAGCTGCCAACAGCTTGGAAGCATTCATATTTGAGACCCAGGACAAGCTG
TACCAGCCCGAGTACCAGGAAGTGTCCACAGAGGAGCAGCGTGAGGAGATCTCTGGGAAGCTCAGCGCCGCATCCACCTGGCTGGAGGAT
GAGGGTGTTGGAGCCACCACAGTGATGTTGAAGGAGAAGCTGGCTGAGCTGAGGAAGCTGTGCCAAGGGCTGTTTTTTCGGGTAGAGGAG
CGCAAGAAGTGGCCCGAACGGCTGTCTGCCCTCGATAATCTCCTCAACCATTCCAGCATGTTCCTCAAGGGGGCCCGGCTCATCCCAGAG
ATGGACCAGATCTTCACTGAGGTGGAGATGACAACGTTAGAGAAAGTCATCAATGAGACCTGGGCCTGGAAGAATGCAACTCTGGCCGAG
CAGGCTAAGCTGCCCGCCACAGAGAAGCCTGTGTTGCTCTCAAAAGACATTGAAGCTAAGATGATGGCCCTGGACCGAGAGGTGCAGTAT
CTGCTCAATAAGGCCAAGTTTACCAAGCCCCGGCCCCGGCCTAAGGACAAGAATGGGACCCGGGCAGAGCCACCCCTCAATGCCAGTGCC
AGTGACCAGGGGGAGAAGGTCATCCCTCCAGCAGGCCAGACTGAAGATGCAGAGCCCATTTCAGAACCTGAGAAAGTAGAGACTGGATCC
GAGCCAGGAGACACTGAGCCTTTGGAGTTAGGAGGTCCTGGAGCAGAACCTGAACAGAAAGAACAATCGACAGGACAGAAGCGGCCTTTG
AAGAACGACGAACTATAACCCCCACCTCTGTTTTCCCCATTCATCTCCACCCCCTTCCCCCACCACTTCTATTTATTTAACATCGAGGGT
TGGGGGAGGGGTTGGTCCTGCCCTCGGCTGGAGTTCCTTTCTCACCCCTGTGATTTGGAGGTGTGGAGAAGGGGAAGGGAGGGACAGCTC
ACTGGTTCCTTCTGCAGTACCTCTGTGGTTAAAAATGGAAACTGTTCTCCTCCCCAGCCCCACTCCCTGTTCCCTACCCATATAGGCCCT
AAATTTGGGAAAAATCACTATTAATTTCTGAATCCTTTGCCTGTGGGTAGGAAGAGAATGGCTGCCAGTGGCTGATGGGTCCCGGTGATG
GGAAGGGTATCAGGTTGCTGGGGAGTTTCCACTCTTCTCTGGTGATTGTTCCTTCCCTCCCTTCCTCTCCCACCATGCGATGAGCATCCT
TTCAGGCCAGTGTCTGCAGAGCCTCAGTTACCAGGTTTGGTTTCTGAGTGCCTATCTGTGCTCTTTCCTCCCTCTGCGGGCTTCTCTTGC
TCTGAGCCTCCCTTCCCCATTCCCCATCCAGCTCCTTTCCCCCTGGGTTTCCTTGGCTTCCTGCAGCAAATTGGGCAGTTCTCTGCCCCT
TGCCTAAAAGCCTGTACCTCTGGATTGGCGGAAGTAAATCTGGAAGGATTCTCACTCGTATTTCCCACCCCTAGTGGCCAGAGGAGGGAG
GGGCACAGTGAAGAAGGGAGCCCACCACCTCTCCGAAGAGGAAAGCCACGTAGAGTGGTTGGCATGGGGTGCCAGCATCGTGCAAGCTCT
GTCATAATCTGCATCTTCCCAGCAGCCTGGTACCCCAGGTTCCTGTAACTCCCTGCCTCCTCCTCTCTTCTGCTGTTCTGCTCCTCCCAG
ACAGAGCCTTTCCCTCACCCCCTGACCCCCTGGGCTGACCAAAATGTGCTTTCTACTGTGAGTCCCTATCCCAAGATCCTGGGGAAAGGA
GAGACCATGGTGTGAATGTAGAGATGCCACCTCCCTCTCTCTGAGGCAGGCCTGTGGATGAAGGAGGAGGGTCAGGGCTGGCCTTCCTCT
GTGCATCACTCTGCTAGGTTGGGGGCCCCCGACCCACCATACCTACGCCTAGGGAGCCCGTCCTCCAGTATTCCGTCTGTAGCAGGAGCT
AGGGCTGCTGCCTCAGCTCCAAGACAAGAATGAACCTGGCTGTGTCAGTCATTTTGTCTTTTCCTTTTTTTTTTTTTTTTGCCACATTGG
CAGAGATGGGACCTAAGGGTCCCACCCCTCACCCCACCCCCACCTCTTCTGTATGTTTGAATTCTTTCAGTAGCTGTTGATGCTGGTTGG

>78349_78349_1_RRP15-HYOU1_RRP15_chr1_218475901_ENST00000366932_HYOU1_chr11_118923144_ENST00000404233_length(amino acids)=805AA_BP=134
MAAAAPDSRVSEEENLKKTPKKKMKMVTGAVASVLEDEATDTSDSEGSCGSEKDHFYSDDDAIEADSEGDAEPCDKENENDGESSVGTNM
GWADAMAKVLNKKTPESKPTILVKNKKLEKEKEKLKQERLEKIKQIEGLMDDVDFKAKVTRVEFEELCADLFERVPGPVQQALQSAEMSL
DEIEQVILVGGATRVPRVQEVLLKAVGKEELGKNINADEAAAMGAVYQAAALSKAFKVKPFVVRDAVVYPILVEFTREVEEEPGIHSLKH
NKRVLFSRMGPYPQRKVITFNRYSHDFNFHINYGDLGFLGPEDLRVFGSQNLTTVKLKGVGDSFKKYPDYESKGIKAHFNLDESGVLSLD
RVESVFETLVEDSAEEESTLTKLGNTISSLFGGGTTPDAKENGTDTVQEEEESPAEGSKDEPGEQVELKEEAEAPVEDGSQPPPPEPKGD
ATPEGEKATEKENGDKSEAQKPSEKAEAGPEGVAPAPEGEKKQKPARKRRMVEEIGVELVVLDLPDLPEDKLAQSVQKLQDLTLRDLEKQ
EREKAANSLEAFIFETQDKLYQPEYQEVSTEEQREEISGKLSAASTWLEDEGVGATTVMLKEKLAELRKLCQGLFFRVEERKKWPERLSA
LDNLLNHSSMFLKGARLIPEMDQIFTEVEMTTLEKVINETWAWKNATLAEQAKLPATEKPVLLSKDIEAKMMALDREVQYLLNKAKFTKP

--------------------------------------------------------------
>78349_78349_2_RRP15-HYOU1_RRP15_chr1_218475901_ENST00000366932_HYOU1_chr11_118923144_ENST00000525859_length(transcript)=2544nt_BP=435nt
ACTGTCAGGTGACGCTTCCGGCGCAGAAAAATGGCAGCCGCCGCTCCGGACTCACGTGTGAGTGAGGAAGAAAACCTGAAAAAGACCCCA
AAGAAGAAGATGAAAATGGTAACTGGAGCCGTAGCGTCGGTGCTGGAAGACGAGGCCACAGACACTTCTGATAGTGAAGGAAGCTGTGGA
TCGGAAAAGGACCACTTTTATTCTGATGATGACGCAATAGAAGCTGACAGTGAGGGTGATGCTGAGCCCTGTGACAAAGAAAATGAAAAT
GATGGAGAATCAAGTGTTGGGACTAATATGGGCTGGGCAGATGCTATGGCTAAAGTCCTCAACAAGAAAACTCCTGAAAGTAAACCTACT
ATTCTGGTCAAAAATAAGAAGCTGGAAAAGGAAAAAGAAAAGTTAAAGCAAGAAAGACTAGAGAAAATAAAACAGATTGAAGGCCTGATG
GATGATGTGGACTTCAAGGCAAAAGTGACTCGTGTGGAATTTGAGGAGTTGTGTGCAGACTTGTTTGAGCGGGTGCCTGGGCCTGTACAG
CAGGCCCTCCAGAGTGCCGAAATGAGTCTGGATGAGATTGAGCAGGTGATCCTGGTGGGTGGGGCCACTCGGGTCCCCAGAGTTCAGGAG
GTGCTGCTGAAGGCCGTGGGCAAGGAGGAGCTGGGGAAGAACATCAATGCAGATGAAGCAGCCGCCATGGGGGCAGTGTACCAGGCAGCT
GCGCTCAGCAAAGCCTTTAAAGTGAAGCCATTTGTCGTCCGAGATGCAGTGGTCTACCCCATCCTGGTGGAGTTCACGAGGGAGGTGGAG
GAGGAGCCTGGGATTCACAGCCTGAAGCACAATAAACGGGTACTCTTCTCTCGGATGGGGCCCTACCCTCAACGCAAAGTCATCACCTTT
AACCGCTACAGCCATGATTTCAACTTCCACATCAACTACGGCGACCTGGGCTTCCTGGGGCCTGAAGATCTTCGGGTATTTGGCTCCCAG
AATCTGACCACAGTGAAGCTAAAAGGGGTGGGTGACAGCTTCAAGAAGTATCCTGACTACGAGTCCAAGGGCATCAAGGCTCACTTCAAC
CTGGATGAGAGTGGCGTGCTCAGTCTAGACAGGGTGGAGTCTGTATTTGAGACACTGGTAGAGGACAGCGCAGAAGAGGAATCTACTCTC
ACCAAACTTGGCAACACCATTTCCAGCCTGTTTGGAGGCGGTACCACACCAGATGCCAAGGAGAATGGTACTGATACTGTCCAGAAACCA
AGTGAGAAGGCAGAGGCAGGGCCTGAGGGCGTCGCTCCAGCCCCAGAGGGAGAGAAGAAGCAGAAGCCCGCCAGGAAGCGGCGAATGGTA
GAGGAGATCGGGGTGGAGCTGGTTGTTCTGGACCTGCCTGACTTGCCAGAGGATAAGCTGGCTCAGTCGGTGCAGAAACTTCAGGACTTG
ACACTCCGAGACCTGGAGAAGCAGGAACGGGAAAAAGCTGCCAACAGCTTGGAAGCATTCATATTTGAGACCCAGGACAAGCTGTACCAG
CCCGAGTACCAGGAAGTGTCCACAGAGGAGCAGCGTGAGGAGATCTCTGGGAAGCTCAGCGCCGCATCCACCTGGCTGGAGGATGAGGGT
GTTGGAGCCACCACAGTGATGTTGAAGGAGAAGCTGGCTGAGCTGAGGAAGCTGTGCCAAGGGCTGTTTTTTCGGGTAGAGGAGCGCAAG
AAGTGGCCCGAACGGCTGTCTGCCCTCGATAATCTCCTCAACCATTCCAGCATGTTCCTCAAGGGGGCCCGGCTCATCCCAGAGATGGAC
CAGATCTTCACTGAGGTGGAGATGACAACGTTAGAGAAAGTCATCAATGAGACCTGGGCCTGGAAGAATGCAACTCTGGCCGAGCAGGCT
AAGCTGCCCGCCACAGAGAAGCCTGTGTTGCTCTCAAAAGACATTGAAGCTAAGATGATGGCCCTGGACCGAGAGGTGCAGTATCTGCTC
AATAAGGCCAAGTTTACCAAGCCCCGGCCCCGGCCTAAGGACAAGAATGGGACCCGGGCAGAGCCACCCCTCAATGCCAGTGCCAGTGAC
CAGGGGGAGAAGGTCATCCCTCCAGCAGGCCAGACTGAAGATGCAGAGCCCATTTCAGAACCTGAGAAAGTAGAGACTGGATCCGAGCCA
GGAGACACTGAGCCTTTGGAGTTAGGAGGTCCTGGAGCAGAACCTGAACAGAAAGAACAATCGACAGGACAGAAGCGGCCTTTGAAGAAC
GACGAACTATAACCCCCACCTCTGTTTTCCCCATTCATCTCCACCCCCTTCCCCCACCACTTCTATTTATTTAACATCGAGGGTTGGGGG
AGGGGTTGGTCCTGCCCTCGGCTGGAGTTCCTTTCTCACCCCTGTGATTTGGAGGTGTGGAGAAGGGGAAGGGAGGGACAGCTCACTGGT
TCCTTCTGCAGTACCTCTGTGGTTAAAAATGGAAACTGTTCTCCTCCCCAGCCCCACTCCCTGTTCCCTACCCATATAGGCCCTAAATTT

>78349_78349_2_RRP15-HYOU1_RRP15_chr1_218475901_ENST00000366932_HYOU1_chr11_118923144_ENST00000525859_length(amino acids)=743AA_BP=134
MAAAAPDSRVSEEENLKKTPKKKMKMVTGAVASVLEDEATDTSDSEGSCGSEKDHFYSDDDAIEADSEGDAEPCDKENENDGESSVGTNM
GWADAMAKVLNKKTPESKPTILVKNKKLEKEKEKLKQERLEKIKQIEGLMDDVDFKAKVTRVEFEELCADLFERVPGPVQQALQSAEMSL
DEIEQVILVGGATRVPRVQEVLLKAVGKEELGKNINADEAAAMGAVYQAAALSKAFKVKPFVVRDAVVYPILVEFTREVEEEPGIHSLKH
NKRVLFSRMGPYPQRKVITFNRYSHDFNFHINYGDLGFLGPEDLRVFGSQNLTTVKLKGVGDSFKKYPDYESKGIKAHFNLDESGVLSLD
RVESVFETLVEDSAEEESTLTKLGNTISSLFGGGTTPDAKENGTDTVQKPSEKAEAGPEGVAPAPEGEKKQKPARKRRMVEEIGVELVVL
DLPDLPEDKLAQSVQKLQDLTLRDLEKQEREKAANSLEAFIFETQDKLYQPEYQEVSTEEQREEISGKLSAASTWLEDEGVGATTVMLKE
KLAELRKLCQGLFFRVEERKKWPERLSALDNLLNHSSMFLKGARLIPEMDQIFTEVEMTTLEKVINETWAWKNATLAEQAKLPATEKPVL
LSKDIEAKMMALDREVQYLLNKAKFTKPRPRPKDKNGTRAEPPLNASASDQGEKVIPPAGQTEDAEPISEPEKVETGSEPGDTEPLELGG

--------------------------------------------------------------
>78349_78349_3_RRP15-HYOU1_RRP15_chr1_218475901_ENST00000366932_HYOU1_chr11_118923144_ENST00000529972_length(transcript)=3664nt_BP=435nt
ACTGTCAGGTGACGCTTCCGGCGCAGAAAAATGGCAGCCGCCGCTCCGGACTCACGTGTGAGTGAGGAAGAAAACCTGAAAAAGACCCCA
AAGAAGAAGATGAAAATGGTAACTGGAGCCGTAGCGTCGGTGCTGGAAGACGAGGCCACAGACACTTCTGATAGTGAAGGAAGCTGTGGA
TCGGAAAAGGACCACTTTTATTCTGATGATGACGCAATAGAAGCTGACAGTGAGGGTGATGCTGAGCCCTGTGACAAAGAAAATGAAAAT
GATGGAGAATCAAGTGTTGGGACTAATATGGGCTGGGCAGATGCTATGGCTAAAGTCCTCAACAAGAAAACTCCTGAAAGTAAACCTACT
ATTCTGGTCAAAAATAAGAAGCTGGAAAAGGAAAAAGAAAAGTTAAAGCAAGAAAGACTAGAGAAAATAAAACAGATTGAAGGCCTGATG
GATGATGTGGACTTCAAGGCAAAAGTGACTCGTGTGGAATTTGAGGAGTTGTGTGCAGACTTGTTTGAGCGGGTGCCTGGGCCTGTACAG
CAGGCCCTCCAGAGTGCCGAAATGAGTCTGGATGAGATTGAGCAGGTGATCCTGGTGGGTGGGGCCACTCGGGTCCCCAGAGTTCAGGAG
GTGCTGCTGAAGGCCGTGGGCAAGGAGGAGCTGGGGAAGAACATCAATGCAGATGAAGCAGCCGCCATGGGGGCAGTGTACCAGGCAGCT
GCGCTCAGCAAAGCCTTTAAAGTGAAGCCATTTGTCGTCCGAGATGCAGTGGTCTACCCCATCCTGGTGGAGTTCACGAGGGAGGTGGAG
GAGGAGCCTGGGATTCACAGCCTGAAGCACAATAAACGGGTACTCTTCTCTCGGATGGGGCCCTACCCTCAACGCAAAGTCATCACCTTT
AACCGCTACAGCCATGATTTCAACTTCCACATCAACTACGGCGACCTGGGCTTCCTGGGGCCTGAAGATCTTCGGGTATTTGGCTCCCAG
AATCTGACCACAGTGAAGCTAAAAGGGGTGGGTGACAGCTTCAAGAAGTATCCTGACTACGAGTCCAAGGGCATCAAGGCTCACTTCAAC
CTGGATGAGAGTGGCGTGCTCAGTCTAGACAGGGTGGAGTCTGTATTTGAGACACTGGTAGAGGACAGCGCAGAAGAGGAATCTACTCTC
ACCAAACTTGGCAACACCATTTCCAGCCTGTTTGGAGGCGGTACCACACCAGATGCCAAGGAGAATGGTACTGATACTGTCCAGAAACCA
AGTGAGAAGGCAGAGGCAGGGCCTGAGGGCGTCGCTCCAGCCCCAGAGGGAGAGAAGAAGCAGAAGCCCGCCAGGAAGCGGCGAATGGTA
GAGGAGATCGGGGTGGAGCTGGTTGTTCTGGACCTGCCTGACTTGCCAGAGGATAAGCTGGCTCAGTCGGTGCAGAAACTTCAGGACTTG
ACACTCCGAGACCTGGAGAAGCAGGAACGGGAAAAAGCTGCCAACAGCTTGGAAGCATTCATATTTGAGACCCAGGACAAGCTGTACCAG
CCCGAGTACCAGGAAGTGTCCACAGAGGAGCAGCGTGAGGAGATCTCTGGGAAGCTCAGCGCCGCATCCACCTGGCTGGAGGATGAGGGT
GTTGGAGCCACCACAGTGATGTTGAAGGAGAAGCTGGCTGAGCTGAGGAAGCTGTGCCAAGGGCTGTTTTTTCGGGTAGAGGAGCGCAAG
AAGTGGCCCGAACGGCTGTCTGCCCTCGATAATCTCCTCAACCATTCCAGCATGTTCCTCAAGGGGGCCCGGCTCATCCCAGAGATGGAC
CAGATCTTCACTGAGGTGGAGATGACAACGTTAGAGAAAGTCATCAATGAGACCTGGGCCTGGAAGAATGCAACTCTGGCCGAGCAGGCT
AAGCTGCCCGCCACAGAGAAGCCTGTGTTGCTCTCAAAAGACATTGAAGCTAAGATGATGGCCCTGGACCGAGAGGTGCAGTATCTGCTC
AATAAGGCCAAGTTTACCAAGCCCCGGCCCCGGCCTAAGGACAAGAATGGGACCCGGGCAGAGCCACCCCTCAATGCCAGTGCCAGTGAC
CAGGGGGAGAAGGTCATCCCTCCAGCAGGCCAGACTGAAGATGCAGAGCCCATTTCAGAACCTGAGAAAGTAGAGACTGGATCCGAGCCA
GGAGACACTGAGCCTTTGGAGTTAGGAGGTCCTGGAGCAGAACCTGAACAGAAAGAACAATCGACAGGACAGAAGCGGCCTTTGAAGAAC
GACGAACTATAACCCCCACCTCTGTTTTCCCCATTCATCTCCACCCCCTTCCCCCACCACTTCTATTTATTTAACATCGAGGGTTGGGGG
AGGGGTTGGTCCTGCCCTCGGCTGGAGTTCCTTTCTCACCCCTGTGATTTGGAGGTGTGGAGAAGGGGAAGGGAGGGACAGCTCACTGGT
TCCTTCTGCAGTACCTCTGTGGTTAAAAATGGAAACTGTTCTCCTCCCCAGCCCCACTCCCTGTTCCCTACCCATATAGGCCCTAAATTT
GGGAAAAATCACTATTAATTTCTGAATCCTTTGCCTGTGGGTAGGAAGAGAATGGCTGCCAGTGGCTGATGGGTCCCGGTGATGGGAAGG
GTATCAGGTTGCTGGGGAGTTTCCACTCTTCTCTGGTGATTGTTCCTTCCCTCCCTTCCTCTCCCACCATGCGATGAGCATCCTTTCAGG
CCAGTGTCTGCAGAGCCTCAGTTACCAGGTTTGGTTTCTGAGTGCCTATCTGTGCTCTTTCCTCCCTCTGCGGGCTTCTCTTGCTCTGAG
CCTCCCTTCCCCATTCCCCATCCAGCTCCTTTCCCCCTGGGTTTCCTTGGCTTCCTGCAGCAAATTGGGCAGTTCTCTGCCCCTTGCCTA
AAAGCCTGTACCTCTGGATTGGCGGAAGTAAATCTGGAAGGATTCTCACTCGTATTTCCCACCCCTAGTGGCCAGAGGAGGGAGGGGCAC
AGTGAAGAAGGGAGCCCACCACCTCTCCGAAGAGGAAAGCCACGTAGAGTGGTTGGCATGGGGTGCCAGCATCGTGCAAGCTCTGTCATA
ATCTGCATCTTCCCAGCAGCCTGGTACCCCAGGTTCCTGTAACTCCCTGCCTCCTCCTCTCTTCTGCTGTTCTGCTCCTCCCAGACAGAG
CCTTTCCCTCACCCCCTGACCCCCTGGGCTGACCAAAATGTGCTTTCTACTGTGAGTCCCTATCCCAAGATCCTGGGGAAAGGAGAGACC
ATGGTGTGAATGTAGAGATGCCACCTCCCTCTCTCTGAGGCAGGCCTGTGGATGAAGGAGGAGGGTCAGGGCTGGCCTTCCTCTGTGCAT
CACTCTGCTAGGTTGGGGGCCCCCGACCCACCATACCTACGCCTAGGGAGCCCGTCCTCCAGTATTCCGTCTGTAGCAGGAGCTAGGGCT
GCTGCCTCAGCTCCAAGACAAGAATGAACCTGGCTGTGTCAGTCATTTTGTCTTTTCCTTTTTTTTTTTTTTTTGCCACATTGGCAGAGA
TGGGACCTAAGGGTCCCACCCCTCACCCCACCCCCACCTCTTCTGTATGTTTGAATTCTTTCAGTAGCTGTTGATGCTGGTTGGACAGGT

>78349_78349_3_RRP15-HYOU1_RRP15_chr1_218475901_ENST00000366932_HYOU1_chr11_118923144_ENST00000529972_length(amino acids)=743AA_BP=134
MAAAAPDSRVSEEENLKKTPKKKMKMVTGAVASVLEDEATDTSDSEGSCGSEKDHFYSDDDAIEADSEGDAEPCDKENENDGESSVGTNM
GWADAMAKVLNKKTPESKPTILVKNKKLEKEKEKLKQERLEKIKQIEGLMDDVDFKAKVTRVEFEELCADLFERVPGPVQQALQSAEMSL
DEIEQVILVGGATRVPRVQEVLLKAVGKEELGKNINADEAAAMGAVYQAAALSKAFKVKPFVVRDAVVYPILVEFTREVEEEPGIHSLKH
NKRVLFSRMGPYPQRKVITFNRYSHDFNFHINYGDLGFLGPEDLRVFGSQNLTTVKLKGVGDSFKKYPDYESKGIKAHFNLDESGVLSLD
RVESVFETLVEDSAEEESTLTKLGNTISSLFGGGTTPDAKENGTDTVQKPSEKAEAGPEGVAPAPEGEKKQKPARKRRMVEEIGVELVVL
DLPDLPEDKLAQSVQKLQDLTLRDLEKQEREKAANSLEAFIFETQDKLYQPEYQEVSTEEQREEISGKLSAASTWLEDEGVGATTVMLKE
KLAELRKLCQGLFFRVEERKKWPERLSALDNLLNHSSMFLKGARLIPEMDQIFTEVEMTTLEKVINETWAWKNATLAEQAKLPATEKPVL
LSKDIEAKMMALDREVQYLLNKAKFTKPRPRPKDKNGTRAEPPLNASASDQGEKVIPPAGQTEDAEPISEPEKVETGSEPGDTEPLELGG

--------------------------------------------------------------
>78349_78349_4_RRP15-HYOU1_RRP15_chr1_218475901_ENST00000366932_HYOU1_chr11_118923144_ENST00000543287_length(transcript)=1879nt_BP=435nt
ACTGTCAGGTGACGCTTCCGGCGCAGAAAAATGGCAGCCGCCGCTCCGGACTCACGTGTGAGTGAGGAAGAAAACCTGAAAAAGACCCCA
AAGAAGAAGATGAAAATGGTAACTGGAGCCGTAGCGTCGGTGCTGGAAGACGAGGCCACAGACACTTCTGATAGTGAAGGAAGCTGTGGA
TCGGAAAAGGACCACTTTTATTCTGATGATGACGCAATAGAAGCTGACAGTGAGGGTGATGCTGAGCCCTGTGACAAAGAAAATGAAAAT
GATGGAGAATCAAGTGTTGGGACTAATATGGGCTGGGCAGATGCTATGGCTAAAGTCCTCAACAAGAAAACTCCTGAAAGTAAACCTACT
ATTCTGGTCAAAAATAAGAAGCTGGAAAAGGAAAAAGAAAAGTTAAAGCAAGAAAGACTAGAGAAAATAAAACAGATTGAAGGCCTGATG
GATGATGTGGACTTCAAGGCAAAAGTGACTCGTGTGGAATTTGAGGAGTTGTGTGCAGACTTGTTTGAGCGGGTGCCTGGGCCTGTACAG
CAGGCCCTCCAGAGTGCCGAAATGAGTCTGGATGAGATTGAGCAGGTGATCCTGGTGGGTGGGGCCACTCGGGTCCCCAGAGTTCAGGAG
GTGCTGCTGAAGGCCGTGGGCAAGGAGGAGCTGGGGAAGAACATCAATGCAGATGAAGCAGCCGCCATGGGGGCAGTGTACCAGGCAGCT
GCGCTCAGCAAAGCCTTTAAAGTGAAGCCATTTGTCGTCCGAGATGCAGTGGTCTACCCCATCCTGGTGGAGTTCACGAGGGAGGTGGAG
GAGGAGCCTGGGATTCACAGCCTGAAGCACAATAAACGGGTACTCTTCTCTCGGATGGGGCCCTACCCTCAACGCAAAGTCATCACCTTT
AACCGCTACAGCCATGATTTCAACTTCCACATCAACTACGGCGACCTGGGCTTCCTGGGGCCTGAAGATCTTCGGGTATTTGGCTCCCAG
AATCTGACCACAGTGAAGCTAAAAGGGGTGGGTGACAGCTTCAAGAAGTATCCTGACTACGAGTCCAAGGGCATCAAGGCTCACTTCAAC
CTGGATGAGAGTGGCGTGCTCAGTCTAGACAGGGTGGAGTCTGTATTTGAGACACTGGTAGAGGACAGCGCAGAAGAGGAATCTACTCTC
ACCAAACTTGGCAACACCATTTCCAGCCTGTTTGGAGGCGGTACCACACCAGATGCCAAGGAGAATGGTACTGATACTGTCCAGATGCTC
TTCCTTTGTCCAGCTAGATTGCCACAGTCCAAGCAGGCCATTGACCGTTTCCATACAGCAGTCACCTGTATGGAACCCCCATGGGGTCGG
CGGTGCCGAGCCAGGCCTGCCTGGAGGCTCTGCTCCTGATCGTTCCCTGGGGCGCCTGTGGTGTTTCCCAGGAGGAAGAGGAGAGCCCTG
CAGAGGGGAGCAAGGACGAGCCTGGGGAGCAGGTGGAGCTCAAGGAGGAAGCTGAGGCCCCAGTGGAGGATGGCTCTCAGCCCCCACCCC
CTGAACCTAAGGGAGATGCAACCCCTGAGGGAGAAAAGGCCACAGAAAAAGAAAATGGGGACAAGTCTGAGGCCCAGAAACCAAGTGAGA
AGGCAGAGGCAGGGCCTGAGGGCGTCGCTCCAGCCCCAGAGGGAGAGAAGAAGCAGAAGCCCGCCAGGAAGCGGCGAATGGTAGAGGAGA
TCGGGGTGGAGCTGGTTGTTCTGGACCTGCCTGACTTGCCAGAGGATAAGCTGGCTCAGTCGGTGCAGAAACTTCAGGACTTGACACTCC

>78349_78349_4_RRP15-HYOU1_RRP15_chr1_218475901_ENST00000366932_HYOU1_chr11_118923144_ENST00000543287_length(amino acids)=452AA_BP=134
MAAAAPDSRVSEEENLKKTPKKKMKMVTGAVASVLEDEATDTSDSEGSCGSEKDHFYSDDDAIEADSEGDAEPCDKENENDGESSVGTNM
GWADAMAKVLNKKTPESKPTILVKNKKLEKEKEKLKQERLEKIKQIEGLMDDVDFKAKVTRVEFEELCADLFERVPGPVQQALQSAEMSL
DEIEQVILVGGATRVPRVQEVLLKAVGKEELGKNINADEAAAMGAVYQAAALSKAFKVKPFVVRDAVVYPILVEFTREVEEEPGIHSLKH
NKRVLFSRMGPYPQRKVITFNRYSHDFNFHINYGDLGFLGPEDLRVFGSQNLTTVKLKGVGDSFKKYPDYESKGIKAHFNLDESGVLSLD
RVESVFETLVEDSAEEESTLTKLGNTISSLFGGGTTPDAKENGTDTVQMLFLCPARLPQSKQAIDRFHTAVTCMEPPWGRRCRARPAWRL

--------------------------------------------------------------

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Fusion Gene PPI Analysis for RRP15-HYOU1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for RRP15-HYOU1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for RRP15-HYOU1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource