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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:RSBN1L-RHBDD2 (FusionGDB2 ID:78387)

Fusion Gene Summary for RSBN1L-RHBDD2

check button Fusion gene summary
Fusion gene informationFusion gene name: RSBN1L-RHBDD2
Fusion gene ID: 78387
HgeneTgene
Gene symbol

RSBN1L

RHBDD2

Gene ID

222194

57414

Gene nameround spermatid basic protein 1 likerhomboid domain containing 2
Synonyms-NPD007|RHBDL7
Cytomap

7q11.23

7q11.23

Type of geneprotein-codingprotein-coding
Descriptionlysine-specific demethylase RSBN1Lround spermatid basic protein 1-like proteinrhomboid domain-containing protein 2rhomboid, veinlet-like 7
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000334955, ENST00000445288, 
ENST00000468304, ENST00000318622, 
ENST00000006777, ENST00000428119, 
Fusion gene scores* DoF score8 X 5 X 6=2409 X 8 X 5=360
# samples 911
** MAII scorelog2(9/240*10)=-1.41503749927884
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(11/360*10)=-1.71049338280502
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: RSBN1L [Title/Abstract] AND RHBDD2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointRSBN1L(77326372)-RHBDD2(75511147), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across RSBN1L (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across RHBDD2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4OVTCGA-09-1673-01ARSBN1Lchr7

77326372

+RHBDD2chr7

75510683

+
ChimerDB4OVTCGA-09-1673-01ARSBN1Lchr7

77326372

+RHBDD2chr7

75511147

+
ChimerDB4OVTCGA-09-1673RSBN1Lchr7

77326372

+RHBDD2chr7

75511146

+


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Fusion Gene ORF analysis for RSBN1L-RHBDD2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000334955ENST00000468304RSBN1Lchr7

77326372

+RHBDD2chr7

75510683

+
5CDS-5UTRENST00000334955ENST00000318622RSBN1Lchr7

77326372

+RHBDD2chr7

75510683

+
5CDS-5UTRENST00000334955ENST00000318622RSBN1Lchr7

77326372

+RHBDD2chr7

75511147

+
5CDS-5UTRENST00000334955ENST00000318622RSBN1Lchr7

77326372

+RHBDD2chr7

75511146

+
5CDS-intronENST00000334955ENST00000006777RSBN1Lchr7

77326372

+RHBDD2chr7

75510683

+
5CDS-intronENST00000334955ENST00000428119RSBN1Lchr7

77326372

+RHBDD2chr7

75510683

+
5CDS-intronENST00000334955ENST00000428119RSBN1Lchr7

77326372

+RHBDD2chr7

75511147

+
5CDS-intronENST00000334955ENST00000428119RSBN1Lchr7

77326372

+RHBDD2chr7

75511146

+
5CDS-intronENST00000334955ENST00000468304RSBN1Lchr7

77326372

+RHBDD2chr7

75511147

+
5CDS-intronENST00000334955ENST00000468304RSBN1Lchr7

77326372

+RHBDD2chr7

75511146

+
In-frameENST00000334955ENST00000006777RSBN1Lchr7

77326372

+RHBDD2chr7

75511147

+
In-frameENST00000334955ENST00000006777RSBN1Lchr7

77326372

+RHBDD2chr7

75511146

+
intron-3CDSENST00000445288ENST00000006777RSBN1Lchr7

77326372

+RHBDD2chr7

75511147

+
intron-3CDSENST00000445288ENST00000006777RSBN1Lchr7

77326372

+RHBDD2chr7

75511146

+
intron-3UTRENST00000445288ENST00000468304RSBN1Lchr7

77326372

+RHBDD2chr7

75510683

+
intron-5UTRENST00000445288ENST00000318622RSBN1Lchr7

77326372

+RHBDD2chr7

75510683

+
intron-5UTRENST00000445288ENST00000318622RSBN1Lchr7

77326372

+RHBDD2chr7

75511147

+
intron-5UTRENST00000445288ENST00000318622RSBN1Lchr7

77326372

+RHBDD2chr7

75511146

+
intron-intronENST00000445288ENST00000006777RSBN1Lchr7

77326372

+RHBDD2chr7

75510683

+
intron-intronENST00000445288ENST00000428119RSBN1Lchr7

77326372

+RHBDD2chr7

75510683

+
intron-intronENST00000445288ENST00000428119RSBN1Lchr7

77326372

+RHBDD2chr7

75511147

+
intron-intronENST00000445288ENST00000428119RSBN1Lchr7

77326372

+RHBDD2chr7

75511146

+
intron-intronENST00000445288ENST00000468304RSBN1Lchr7

77326372

+RHBDD2chr7

75511147

+
intron-intronENST00000445288ENST00000468304RSBN1Lchr7

77326372

+RHBDD2chr7

75511146

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000334955RSBN1Lchr777326372+ENST00000006777RHBDD2chr775511147+2102613271529500
ENST00000334955RSBN1Lchr777326372+ENST00000006777RHBDD2chr775511146+2102613271529500

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000334955ENST00000006777RSBN1Lchr777326372+RHBDD2chr775511147+0.161805450.8381946
ENST00000334955ENST00000006777RSBN1Lchr777326372+RHBDD2chr775511146+0.161805450.8381946

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Fusion Genomic Features for RSBN1L-RHBDD2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
RSBN1Lchr777326372+RHBDD2chr775511146+5.72E-070.9999994
RSBN1Lchr777326372+RHBDD2chr775511146+5.72E-070.9999994
RSBN1Lchr777326372+RHBDD2chr775510682+2.53E-070.99999976
RSBN1Lchr777326372+RHBDD2chr775511146+5.72E-070.9999994
RSBN1Lchr777326372+RHBDD2chr775511146+5.72E-070.9999994
RSBN1Lchr777326372+RHBDD2chr775510682+2.53E-070.99999976

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for RSBN1L-RHBDD2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr7:77326372/chr7:75511147)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneRSBN1Lchr7:77326372chr7:75511146ENST00000334955+1812_15195847.0Compositional biasNote=Poly-Ala
HgeneRSBN1Lchr7:77326372chr7:75511146ENST00000334955+18146_155195847.0Compositional biasNote=Poly-Ala
HgeneRSBN1Lchr7:77326372chr7:75511146ENST00000334955+1876_121195847.0Compositional biasNote=Ser-rich
HgeneRSBN1Lchr7:77326372chr7:75511147ENST00000334955+1812_15195847.0Compositional biasNote=Poly-Ala
HgeneRSBN1Lchr7:77326372chr7:75511147ENST00000334955+18146_155195847.0Compositional biasNote=Poly-Ala
HgeneRSBN1Lchr7:77326372chr7:75511147ENST00000334955+1876_121195847.0Compositional biasNote=Ser-rich
TgeneRHBDD2chr7:77326372chr7:75511146ENST0000000677704100_12059365.0TransmembraneHelical
TgeneRHBDD2chr7:77326372chr7:75511146ENST0000000677704158_17859365.0TransmembraneHelical
TgeneRHBDD2chr7:77326372chr7:75511146ENST0000000677704184_20459365.0TransmembraneHelical
TgeneRHBDD2chr7:77326372chr7:75511146ENST000000067770463_8359365.0TransmembraneHelical
TgeneRHBDD2chr7:77326372chr7:75511146ENST0000031862215100_1200224.0TransmembraneHelical
TgeneRHBDD2chr7:77326372chr7:75511146ENST000003186221511_310224.0TransmembraneHelical
TgeneRHBDD2chr7:77326372chr7:75511146ENST0000031862215158_1780224.0TransmembraneHelical
TgeneRHBDD2chr7:77326372chr7:75511146ENST0000031862215184_2040224.0TransmembraneHelical
TgeneRHBDD2chr7:77326372chr7:75511146ENST000003186221563_830224.0TransmembraneHelical
TgeneRHBDD2chr7:77326372chr7:75511146ENST0000042811903100_1200224.0TransmembraneHelical
TgeneRHBDD2chr7:77326372chr7:75511146ENST000004281190311_310224.0TransmembraneHelical
TgeneRHBDD2chr7:77326372chr7:75511146ENST0000042811903158_1780224.0TransmembraneHelical
TgeneRHBDD2chr7:77326372chr7:75511146ENST0000042811903184_2040224.0TransmembraneHelical
TgeneRHBDD2chr7:77326372chr7:75511146ENST000004281190363_830224.0TransmembraneHelical
TgeneRHBDD2chr7:77326372chr7:75511147ENST0000000677704100_12059365.0TransmembraneHelical
TgeneRHBDD2chr7:77326372chr7:75511147ENST0000000677704158_17859365.0TransmembraneHelical
TgeneRHBDD2chr7:77326372chr7:75511147ENST0000000677704184_20459365.0TransmembraneHelical
TgeneRHBDD2chr7:77326372chr7:75511147ENST000000067770463_8359365.0TransmembraneHelical
TgeneRHBDD2chr7:77326372chr7:75511147ENST0000031862215100_1200224.0TransmembraneHelical
TgeneRHBDD2chr7:77326372chr7:75511147ENST000003186221511_310224.0TransmembraneHelical
TgeneRHBDD2chr7:77326372chr7:75511147ENST0000031862215158_1780224.0TransmembraneHelical
TgeneRHBDD2chr7:77326372chr7:75511147ENST0000031862215184_2040224.0TransmembraneHelical
TgeneRHBDD2chr7:77326372chr7:75511147ENST000003186221563_830224.0TransmembraneHelical
TgeneRHBDD2chr7:77326372chr7:75511147ENST0000042811903100_1200224.0TransmembraneHelical
TgeneRHBDD2chr7:77326372chr7:75511147ENST000004281190311_310224.0TransmembraneHelical
TgeneRHBDD2chr7:77326372chr7:75511147ENST0000042811903158_1780224.0TransmembraneHelical
TgeneRHBDD2chr7:77326372chr7:75511147ENST0000042811903184_2040224.0TransmembraneHelical
TgeneRHBDD2chr7:77326372chr7:75511147ENST000004281190363_830224.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneRSBN1Lchr7:77326372chr7:75511146ENST00000334955+18197_274195847.0Compositional biasNote=Lys-rich
HgeneRSBN1Lchr7:77326372chr7:75511146ENST00000445288+1812_150577.0Compositional biasNote=Poly-Ala
HgeneRSBN1Lchr7:77326372chr7:75511146ENST00000445288+18146_1550577.0Compositional biasNote=Poly-Ala
HgeneRSBN1Lchr7:77326372chr7:75511146ENST00000445288+18197_2740577.0Compositional biasNote=Lys-rich
HgeneRSBN1Lchr7:77326372chr7:75511146ENST00000445288+1876_1210577.0Compositional biasNote=Ser-rich
HgeneRSBN1Lchr7:77326372chr7:75511147ENST00000334955+18197_274195847.0Compositional biasNote=Lys-rich
HgeneRSBN1Lchr7:77326372chr7:75511147ENST00000445288+1812_150577.0Compositional biasNote=Poly-Ala
HgeneRSBN1Lchr7:77326372chr7:75511147ENST00000445288+18146_1550577.0Compositional biasNote=Poly-Ala
HgeneRSBN1Lchr7:77326372chr7:75511147ENST00000445288+18197_2740577.0Compositional biasNote=Lys-rich
HgeneRSBN1Lchr7:77326372chr7:75511147ENST00000445288+1876_1210577.0Compositional biasNote=Ser-rich
TgeneRHBDD2chr7:77326372chr7:75511146ENST000000067770411_3159365.0TransmembraneHelical
TgeneRHBDD2chr7:77326372chr7:75511147ENST000000067770411_3159365.0TransmembraneHelical


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Fusion Gene Sequence for RSBN1L-RHBDD2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>78387_78387_1_RSBN1L-RHBDD2_RSBN1L_chr7_77326372_ENST00000334955_RHBDD2_chr7_75511146_ENST00000006777_length(transcript)=2102nt_BP=613nt
GGAGAGTAAATACAACAGGAGCGCAAAATGGCGGAACCGCCGAGCCCCGTGCACTGTGTCGCTGCCGCGGCCCCCACCGCCACCGTCTCG
GAGAAAGAACCGTTTGGCAAGCTGCAACTCTCCTCCCGGGACCCTCCGGGTTCTCTGTCCGCCAAGAAGGTCCGGACTGAGGAGAAGAAG
GCACCGCGGAGAGTGAACGGAGAAGGGGGCAGCGGCGGGAACAGCAGGCAGCTGCAGCCGCCGGCAGCACCTTCGCCTCAGAGCTATGGC
AGCCCCGCGTCTTGGAGCTTTGCCCCTCTGTCTGCTGCTCCCTCCCCGTCCTCTTCTCGGAGCAGTTTCTCTTTCTCCGCTGGCACGGCC
GTTCCCTCCTCAGCCTCCGCTTCCTTGTCTCAGCCGGTGCCGCGCAAACTGCTGGTCCCTCCTACGCTGCTGCACGCTCAGCCTCACCAT
CTCCTCCTGCCCGCCGCCGCCGCCGCTGCCTCGGCTAACGCCAAGTCGCGCAGACCTAAGGAGAAGCGGGAGAAGGAGAGGAGGAGGCAC
GGTCTCGGTGGGGCCCGAGAGGCCGGCGGGGCCTCCCGGGAGGAGAACGGGGAGGTGAAGCCGCTGCCCCGAGTTTACAGGCTGGTAACC
TACATCTTTGTCTACGAGAATCCCATCTCCCTGCTCTGCGGCGCTATCATCATCTGGCGCTTTGCTGGCAATTTCGAGAGAACCGTGGGC
ACCGTCCGCCACTGCTTCTTCACCGTGATCTTCGCCATCTTCTCCGCTATCATCTTCCTGTCATTCGAGGCTGTGTCATCACTGTCAAAG
CTGGGGGAAGTGGAGGATGCCAGAGGTTTCACCCCAGTGGCCTTTGCCATGCTGGGAGTCACCACCGTCCGTTCTCGGATGAGGCGGGCC
CTGGTGTTTGGCATGGTTGTGCCCTCAGTCCTGGTTCCGTGGCTCCTGCTGGGTGCCTCGTGGCTCATTCCCCAGACCTCTTTCCTCAGT
AATGTCTGCGGGCTGTCCATCGGGCTGGCCTATGGCCTCACCTACTGCTATTCCATCGACCTCTCAGAGCGAGTGGCACTGAAGCTCGAT
CAGACCTTCCCCTTCAGCCTGATGAGGAGGATATCCGTGTTCAAGTACGTCTCAGGGTCTTCAGCCGAGAGGAGGGCAGCCCAGAGCCGG
AAACTGAACCCGGTGCCTGGCTCCTACCCCACACAGAGCTGCCACCCTCACCTGTCCCCAAGCCACCCTGTGTCCCAGACGCAGCACGCC
AGTGGTCAGAAGCTGGCCTCCTGGCCCTCCTGCACCCCCGGGCACATGCCCACCTTGCCTCCGTACCAGCCTGCCTCCGGCCTGTGCTAT
GTGCAGAACCACTTTGGTCCAAACCCCACCTCCTCCAGTGTCTACCCAGCTTCTGCGGGCACCTCCCTGGGCATCCAGCCCCCCACGCCT
GTGAACAGCCCTGGCACGGTGTATTCTGGGGCCTTGGGCACACCAGGGGCTGCAGGCTCCAAGGAGTCCTCCAGGGTCCCCATGCCCTGA
GAGAATTTCTAGGGAAGTCATCTCACTTGGCCTTCTGAAGGTCCTCCCTAAGAGTCTCCTGACAAAAGTTACTTATTGAACACCTCTATG
TGCCAGGCTCTGTGTTGGGTACTTTGATCAATGCCCCTGTTTCAGTCTCATCTGTACTCACGGCAGCCCTGTGGAGTACGGTGTACTGGC
CCAGCTTACAGATGCAGAAAGCGAGACGTTCTGCCATCAGATAAAGTCACGTGGCTCTTTAGTAACACGGACAAGGCTCCTCGCCAAGGA
ACTCGTGGCAGAAGAGGGCAGCAGTTGGCAGTAGCTGCCGATGTCTGTCCCCAGCTCCACCATTCCTCCCTGTGGCTGTGCCGTGCTCGT
GGTTTCAGTGTCCGTGTGTCCATGTGTCTGCCCTTCAGGAGCTCGCAGCTGGTGTGCTTGGCGGTCCCAGGCCTGTGTAGTGTCTCTCCC
CTGCTGCGGGCGCCCCCACCCCGATTCCTCTCCCCAGAAGCGGTGGGATGGGCCCCCATGAACTGCAGCAGCATGCTGAGGTGTCCATGT

>78387_78387_1_RSBN1L-RHBDD2_RSBN1L_chr7_77326372_ENST00000334955_RHBDD2_chr7_75511146_ENST00000006777_length(amino acids)=500AA_BP=195
MAEPPSPVHCVAAAAPTATVSEKEPFGKLQLSSRDPPGSLSAKKVRTEEKKAPRRVNGEGGSGGNSRQLQPPAAPSPQSYGSPASWSFAP
LSAAPSPSSSRSSFSFSAGTAVPSSASASLSQPVPRKLLVPPTLLHAQPHHLLLPAAAAAASANAKSRRPKEKREKERRRHGLGGAREAG
GASREENGEVKPLPRVYRLVTYIFVYENPISLLCGAIIIWRFAGNFERTVGTVRHCFFTVIFAIFSAIIFLSFEAVSSLSKLGEVEDARG
FTPVAFAMLGVTTVRSRMRRALVFGMVVPSVLVPWLLLGASWLIPQTSFLSNVCGLSIGLAYGLTYCYSIDLSERVALKLDQTFPFSLMR
RISVFKYVSGSSAERRAAQSRKLNPVPGSYPTQSCHPHLSPSHPVSQTQHASGQKLASWPSCTPGHMPTLPPYQPASGLCYVQNHFGPNP

--------------------------------------------------------------
>78387_78387_2_RSBN1L-RHBDD2_RSBN1L_chr7_77326372_ENST00000334955_RHBDD2_chr7_75511147_ENST00000006777_length(transcript)=2102nt_BP=613nt
GGAGAGTAAATACAACAGGAGCGCAAAATGGCGGAACCGCCGAGCCCCGTGCACTGTGTCGCTGCCGCGGCCCCCACCGCCACCGTCTCG
GAGAAAGAACCGTTTGGCAAGCTGCAACTCTCCTCCCGGGACCCTCCGGGTTCTCTGTCCGCCAAGAAGGTCCGGACTGAGGAGAAGAAG
GCACCGCGGAGAGTGAACGGAGAAGGGGGCAGCGGCGGGAACAGCAGGCAGCTGCAGCCGCCGGCAGCACCTTCGCCTCAGAGCTATGGC
AGCCCCGCGTCTTGGAGCTTTGCCCCTCTGTCTGCTGCTCCCTCCCCGTCCTCTTCTCGGAGCAGTTTCTCTTTCTCCGCTGGCACGGCC
GTTCCCTCCTCAGCCTCCGCTTCCTTGTCTCAGCCGGTGCCGCGCAAACTGCTGGTCCCTCCTACGCTGCTGCACGCTCAGCCTCACCAT
CTCCTCCTGCCCGCCGCCGCCGCCGCTGCCTCGGCTAACGCCAAGTCGCGCAGACCTAAGGAGAAGCGGGAGAAGGAGAGGAGGAGGCAC
GGTCTCGGTGGGGCCCGAGAGGCCGGCGGGGCCTCCCGGGAGGAGAACGGGGAGGTGAAGCCGCTGCCCCGAGTTTACAGGCTGGTAACC
TACATCTTTGTCTACGAGAATCCCATCTCCCTGCTCTGCGGCGCTATCATCATCTGGCGCTTTGCTGGCAATTTCGAGAGAACCGTGGGC
ACCGTCCGCCACTGCTTCTTCACCGTGATCTTCGCCATCTTCTCCGCTATCATCTTCCTGTCATTCGAGGCTGTGTCATCACTGTCAAAG
CTGGGGGAAGTGGAGGATGCCAGAGGTTTCACCCCAGTGGCCTTTGCCATGCTGGGAGTCACCACCGTCCGTTCTCGGATGAGGCGGGCC
CTGGTGTTTGGCATGGTTGTGCCCTCAGTCCTGGTTCCGTGGCTCCTGCTGGGTGCCTCGTGGCTCATTCCCCAGACCTCTTTCCTCAGT
AATGTCTGCGGGCTGTCCATCGGGCTGGCCTATGGCCTCACCTACTGCTATTCCATCGACCTCTCAGAGCGAGTGGCACTGAAGCTCGAT
CAGACCTTCCCCTTCAGCCTGATGAGGAGGATATCCGTGTTCAAGTACGTCTCAGGGTCTTCAGCCGAGAGGAGGGCAGCCCAGAGCCGG
AAACTGAACCCGGTGCCTGGCTCCTACCCCACACAGAGCTGCCACCCTCACCTGTCCCCAAGCCACCCTGTGTCCCAGACGCAGCACGCC
AGTGGTCAGAAGCTGGCCTCCTGGCCCTCCTGCACCCCCGGGCACATGCCCACCTTGCCTCCGTACCAGCCTGCCTCCGGCCTGTGCTAT
GTGCAGAACCACTTTGGTCCAAACCCCACCTCCTCCAGTGTCTACCCAGCTTCTGCGGGCACCTCCCTGGGCATCCAGCCCCCCACGCCT
GTGAACAGCCCTGGCACGGTGTATTCTGGGGCCTTGGGCACACCAGGGGCTGCAGGCTCCAAGGAGTCCTCCAGGGTCCCCATGCCCTGA
GAGAATTTCTAGGGAAGTCATCTCACTTGGCCTTCTGAAGGTCCTCCCTAAGAGTCTCCTGACAAAAGTTACTTATTGAACACCTCTATG
TGCCAGGCTCTGTGTTGGGTACTTTGATCAATGCCCCTGTTTCAGTCTCATCTGTACTCACGGCAGCCCTGTGGAGTACGGTGTACTGGC
CCAGCTTACAGATGCAGAAAGCGAGACGTTCTGCCATCAGATAAAGTCACGTGGCTCTTTAGTAACACGGACAAGGCTCCTCGCCAAGGA
ACTCGTGGCAGAAGAGGGCAGCAGTTGGCAGTAGCTGCCGATGTCTGTCCCCAGCTCCACCATTCCTCCCTGTGGCTGTGCCGTGCTCGT
GGTTTCAGTGTCCGTGTGTCCATGTGTCTGCCCTTCAGGAGCTCGCAGCTGGTGTGCTTGGCGGTCCCAGGCCTGTGTAGTGTCTCTCCC
CTGCTGCGGGCGCCCCCACCCCGATTCCTCTCCCCAGAAGCGGTGGGATGGGCCCCCATGAACTGCAGCAGCATGCTGAGGTGTCCATGT

>78387_78387_2_RSBN1L-RHBDD2_RSBN1L_chr7_77326372_ENST00000334955_RHBDD2_chr7_75511147_ENST00000006777_length(amino acids)=500AA_BP=195
MAEPPSPVHCVAAAAPTATVSEKEPFGKLQLSSRDPPGSLSAKKVRTEEKKAPRRVNGEGGSGGNSRQLQPPAAPSPQSYGSPASWSFAP
LSAAPSPSSSRSSFSFSAGTAVPSSASASLSQPVPRKLLVPPTLLHAQPHHLLLPAAAAAASANAKSRRPKEKREKERRRHGLGGAREAG
GASREENGEVKPLPRVYRLVTYIFVYENPISLLCGAIIIWRFAGNFERTVGTVRHCFFTVIFAIFSAIIFLSFEAVSSLSKLGEVEDARG
FTPVAFAMLGVTTVRSRMRRALVFGMVVPSVLVPWLLLGASWLIPQTSFLSNVCGLSIGLAYGLTYCYSIDLSERVALKLDQTFPFSLMR
RISVFKYVSGSSAERRAAQSRKLNPVPGSYPTQSCHPHLSPSHPVSQTQHASGQKLASWPSCTPGHMPTLPPYQPASGLCYVQNHFGPNP

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Fusion Gene PPI Analysis for RSBN1L-RHBDD2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for RSBN1L-RHBDD2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for RSBN1L-RHBDD2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource