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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:RSF1-TENM4 (FusionGDB2 ID:78414)

Fusion Gene Summary for RSF1-TENM4

check button Fusion gene summary
Fusion gene informationFusion gene name: RSF1-TENM4
Fusion gene ID: 78414
HgeneTgene
Gene symbol

RSF1

TENM4

Gene ID

51773

26011

Gene nameremodeling and spacing factor 1teneurin transmembrane protein 4
SynonymsHBXAP|RSF-1|XAP8|p325Doc4|ETM5|ODZ4|TEN4|TNM4|Ten-M4|ten-4
Cytomap

11q14.1

11q14.1

Type of geneprotein-codingprotein-coding
Descriptionremodeling and spacing factor 1HBV pX-associated protein 8hepatitis B virus x-associated proteinp325 subunit of RSF chromatin-remodeling complexteneurin-4odz, odd Oz/ten-m homolog 4protein Odd Oz/ten-m homolog 4tenascin-M4
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000308488, ENST00000360355, 
ENST00000530604, ENST00000480887, 
ENST00000533038, ENST00000278550, 
Fusion gene scores* DoF score24 X 20 X 11=528017 X 17 X 9=2601
# samples 3218
** MAII scorelog2(32/5280*10)=-4.04439411935845
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(18/2601*10)=-3.85299758761332
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: RSF1 [Title/Abstract] AND TENM4 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointRSF1(77531574)-TENM4(78449615), # samples:2
Anticipated loss of major functional domain due to fusion event.RSF1-TENM4 seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor due to the frame-shifted ORF.
RSF1-TENM4 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
RSF1-TENM4 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneRSF1

GO:0006334

nucleosome assembly

12972596

HgeneRSF1

GO:0006338

chromatin remodeling

9836642

HgeneRSF1

GO:0006352

DNA-templated transcription, initiation

9836642

HgeneRSF1

GO:0016584

nucleosome positioning

9836642

HgeneRSF1

GO:0043392

negative regulation of DNA binding

12972596

HgeneRSF1

GO:0045892

negative regulation of transcription, DNA-templated

11944984

HgeneRSF1

GO:0045893

positive regulation of transcription, DNA-templated

11788598

HgeneRSF1

GO:0050434

positive regulation of viral transcription

11788598


check buttonFusion gene breakpoints across RSF1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across TENM4 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-BH-A0EB-01ARSF1chr11

77436590

-TENM4chr11

78567223

-
ChimerDB4HNSCTCGA-BA-A8YP-01ARSF1chr11

77531574

-TENM4chr11

78449615

-
ChimerDB4HNSCTCGA-BA-A8YPRSF1chr11

77531574

-TENM4chr11

78449615

-


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Fusion Gene ORF analysis for RSF1-TENM4

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000308488ENST00000533038RSF1chr11

77436590

-TENM4chr11

78567223

-
5CDS-intronENST00000308488ENST00000533038RSF1chr11

77531574

-TENM4chr11

78449615

-
5CDS-intronENST00000360355ENST00000533038RSF1chr11

77436590

-TENM4chr11

78567223

-
5CDS-intronENST00000360355ENST00000533038RSF1chr11

77531574

-TENM4chr11

78449615

-
5UTR-3CDSENST00000530604ENST00000278550RSF1chr11

77531574

-TENM4chr11

78449615

-
5UTR-intronENST00000530604ENST00000533038RSF1chr11

77531574

-TENM4chr11

78449615

-
Frame-shiftENST00000308488ENST00000278550RSF1chr11

77531574

-TENM4chr11

78449615

-
Frame-shiftENST00000360355ENST00000278550RSF1chr11

77531574

-TENM4chr11

78449615

-
In-frameENST00000308488ENST00000278550RSF1chr11

77436590

-TENM4chr11

78567223

-
In-frameENST00000360355ENST00000278550RSF1chr11

77436590

-TENM4chr11

78567223

-
intron-3CDSENST00000480887ENST00000278550RSF1chr11

77436590

-TENM4chr11

78567223

-
intron-3CDSENST00000480887ENST00000278550RSF1chr11

77531574

-TENM4chr11

78449615

-
intron-3CDSENST00000530604ENST00000278550RSF1chr11

77436590

-TENM4chr11

78567223

-
intron-intronENST00000480887ENST00000533038RSF1chr11

77436590

-TENM4chr11

78567223

-
intron-intronENST00000480887ENST00000533038RSF1chr11

77531574

-TENM4chr11

78449615

-
intron-intronENST00000530604ENST00000533038RSF1chr11

77436590

-TENM4chr11

78567223

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000308488RSF1chr1177436590-ENST00000278550TENM4chr1178567223-13318103630380902595
ENST00000360355RSF1chr1177436590-ENST00000278550TENM4chr1178567223-1304276012078142564

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000308488ENST00000278550RSF1chr1177436590-TENM4chr1178567223-0.0011885770.9988115
ENST00000360355ENST00000278550RSF1chr1177436590-TENM4chr1178567223-0.0009902990.9990097

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Fusion Genomic Features for RSF1-TENM4


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for RSF1-TENM4


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr11:77531574/chr11:78449615)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneRSF1chr11:77436590chr11:78567223ENST00000308488-51617_842441442.0DomainNote=DDT
HgeneRSF1chr11:77436590chr11:78567223ENST00000360355-41517_842131411.0DomainNote=DDT
TgeneTENM4chr11:77436590chr11:78567223ENST00000278550934562_5934182770.0DomainEGF-like 1
TgeneTENM4chr11:77436590chr11:78567223ENST00000278550934594_6244182770.0DomainEGF-like 2
TgeneTENM4chr11:77436590chr11:78567223ENST00000278550934626_6584182770.0DomainEGF-like 3
TgeneTENM4chr11:77436590chr11:78567223ENST00000278550934659_6904182770.0DomainEGF-like 4
TgeneTENM4chr11:77436590chr11:78567223ENST00000278550934692_7254182770.0DomainEGF-like 5
TgeneTENM4chr11:77436590chr11:78567223ENST00000278550934726_7574182770.0DomainEGF-like 6
TgeneTENM4chr11:77436590chr11:78567223ENST00000278550934758_7874182770.0DomainEGF-like 7
TgeneTENM4chr11:77436590chr11:78567223ENST00000278550934788_8314182770.0DomainEGF-like 8
TgeneTENM4chr11:77436590chr11:78567223ENST000002785509341216_12594182770.0RepeatNote=NHL 1
TgeneTENM4chr11:77436590chr11:78567223ENST000002785509341264_13084182770.0RepeatNote=NHL 2
TgeneTENM4chr11:77436590chr11:78567223ENST000002785509341334_13784182770.0RepeatNote=NHL 3
TgeneTENM4chr11:77436590chr11:78567223ENST000002785509341393_14444182770.0RepeatNote=NHL 4
TgeneTENM4chr11:77436590chr11:78567223ENST000002785509341523_15664182770.0RepeatNote=NHL 5
TgeneTENM4chr11:77436590chr11:78567223ENST000002785509341576_15954182770.0RepeatNote=YD 1
TgeneTENM4chr11:77436590chr11:78567223ENST000002785509341612_16324182770.0RepeatNote=YD 2
TgeneTENM4chr11:77436590chr11:78567223ENST000002785509341675_16944182770.0RepeatNote=YD 3
TgeneTENM4chr11:77436590chr11:78567223ENST000002785509341695_17174182770.0RepeatNote=YD 4
TgeneTENM4chr11:77436590chr11:78567223ENST000002785509341887_19064182770.0RepeatNote=YD 5
TgeneTENM4chr11:77436590chr11:78567223ENST000002785509341928_19464182770.0RepeatNote=YD 6
TgeneTENM4chr11:77436590chr11:78567223ENST000002785509341947_19674182770.0RepeatNote=YD 7
TgeneTENM4chr11:77436590chr11:78567223ENST000002785509341974_19914182770.0RepeatNote=YD 8
TgeneTENM4chr11:77436590chr11:78567223ENST000002785509341992_20134182770.0RepeatNote=YD 9
TgeneTENM4chr11:77436590chr11:78567223ENST000002785509342014_20314182770.0RepeatNote=YD 10
TgeneTENM4chr11:77436590chr11:78567223ENST000002785509342034_20544182770.0RepeatNote=YD 11
TgeneTENM4chr11:77436590chr11:78567223ENST000002785509342057_20774182770.0RepeatNote=YD 12
TgeneTENM4chr11:77436590chr11:78567223ENST000002785509342085_21044182770.0RepeatNote=YD 13
TgeneTENM4chr11:77436590chr11:78567223ENST000002785509342110_21274182770.0RepeatNote=YD 14
TgeneTENM4chr11:77436590chr11:78567223ENST000002785509342128_21544182770.0RepeatNote=YD 15
TgeneTENM4chr11:77436590chr11:78567223ENST000002785509342156_21694182770.0RepeatNote=YD 16
TgeneTENM4chr11:77436590chr11:78567223ENST000002785509342170_21934182770.0RepeatNote=YD 17
TgeneTENM4chr11:77436590chr11:78567223ENST000002785509342196_22164182770.0RepeatNote=YD 18
TgeneTENM4chr11:77436590chr11:78567223ENST000002785509342217_22374182770.0RepeatNote=YD 19
TgeneTENM4chr11:77436590chr11:78567223ENST000002785509342239_22594182770.0RepeatNote=YD 20
TgeneTENM4chr11:77436590chr11:78567223ENST000002785509342271_22914182770.0RepeatNote=YD 21
TgeneTENM4chr11:77436590chr11:78567223ENST000002785509342293_23134182770.0RepeatNote=YD 22
TgeneTENM4chr11:77436590chr11:78567223ENST000002785509342339_23804182770.0RepeatNote=YD 23

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneRSF1chr11:77436590chr11:78567223ENST00000308488-516942_10122441442.0Coiled coilOntology_term=ECO:0000255
HgeneRSF1chr11:77436590chr11:78567223ENST00000360355-415942_10122131411.0Coiled coilOntology_term=ECO:0000255
HgeneRSF1chr11:77436590chr11:78567223ENST00000480887-111942_101201190.0Coiled coilOntology_term=ECO:0000255
HgeneRSF1chr11:77436590chr11:78567223ENST00000308488-5161080_10832441442.0Compositional biasNote=Poly-Ala
HgeneRSF1chr11:77436590chr11:78567223ENST00000308488-5161146_12432441442.0Compositional biasNote=Arg-rich
HgeneRSF1chr11:77436590chr11:78567223ENST00000308488-5161286_12922441442.0Compositional biasNote=Poly-Glu
HgeneRSF1chr11:77436590chr11:78567223ENST00000308488-5161419_14242441442.0Compositional biasNote=Poly-Glu
HgeneRSF1chr11:77436590chr11:78567223ENST00000308488-516226_3722441442.0Compositional biasNote=Glu-rich
HgeneRSF1chr11:77436590chr11:78567223ENST00000308488-516875_8842441442.0Compositional biasNote=Poly-Glu
HgeneRSF1chr11:77436590chr11:78567223ENST00000360355-4151080_10832131411.0Compositional biasNote=Poly-Ala
HgeneRSF1chr11:77436590chr11:78567223ENST00000360355-4151146_12432131411.0Compositional biasNote=Arg-rich
HgeneRSF1chr11:77436590chr11:78567223ENST00000360355-4151286_12922131411.0Compositional biasNote=Poly-Glu
HgeneRSF1chr11:77436590chr11:78567223ENST00000360355-4151419_14242131411.0Compositional biasNote=Poly-Glu
HgeneRSF1chr11:77436590chr11:78567223ENST00000360355-415226_3722131411.0Compositional biasNote=Glu-rich
HgeneRSF1chr11:77436590chr11:78567223ENST00000360355-415875_8842131411.0Compositional biasNote=Poly-Glu
HgeneRSF1chr11:77436590chr11:78567223ENST00000480887-1111080_108301190.0Compositional biasNote=Poly-Ala
HgeneRSF1chr11:77436590chr11:78567223ENST00000480887-1111146_124301190.0Compositional biasNote=Arg-rich
HgeneRSF1chr11:77436590chr11:78567223ENST00000480887-1111286_129201190.0Compositional biasNote=Poly-Glu
HgeneRSF1chr11:77436590chr11:78567223ENST00000480887-1111419_142401190.0Compositional biasNote=Poly-Glu
HgeneRSF1chr11:77436590chr11:78567223ENST00000480887-111226_37201190.0Compositional biasNote=Glu-rich
HgeneRSF1chr11:77436590chr11:78567223ENST00000480887-111875_88401190.0Compositional biasNote=Poly-Glu
HgeneRSF1chr11:77436590chr11:78567223ENST00000480887-11117_8401190.0DomainNote=DDT
HgeneRSF1chr11:77436590chr11:78567223ENST00000308488-516891_9412441442.0Zinc fingerPHD-type
HgeneRSF1chr11:77436590chr11:78567223ENST00000360355-415891_9412131411.0Zinc fingerPHD-type
HgeneRSF1chr11:77436590chr11:78567223ENST00000480887-111891_94101190.0Zinc fingerPHD-type
TgeneTENM4chr11:77436590chr11:78567223ENST00000278550934179_1824182770.0Compositional biasNote=Poly-Pro
TgeneTENM4chr11:77436590chr11:78567223ENST000002785509341_3414182770.0DomainTeneurin N-terminal
TgeneTENM4chr11:77436590chr11:78567223ENST000002785509341_3454182770.0Topological domainCytoplasmic
TgeneTENM4chr11:77436590chr11:78567223ENST00000278550934367_27694182770.0Topological domainExtracellular
TgeneTENM4chr11:77436590chr11:78567223ENST00000278550934346_3664182770.0TransmembraneHelical


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Fusion Gene Sequence for RSF1-TENM4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>78414_78414_1_RSF1-TENM4_RSF1_chr11_77436590_ENST00000308488_TENM4_chr11_78567223_ENST00000278550_length(transcript)=13318nt_BP=1036nt
TTGTTTTCATTCCCCCTGTCACACGAGGCAGTGGCAAGCCCGAAGGGGAGGAGAGAAGGGGGCGGAAAGAGGGCGGAAAGTGAAAGGCGC
CGAGGGCCGCTCTGTCTCCCGTCTGACTCGGTTCTCGACTGCTCCGGGCCGCCGATGTATTGTGGGATCGCGGAGCCGTCCCTGAGACGC
TGGGATCCGCAGAGGAGCCCACTTGAGAGCGCCTCCTGTCGTCTGTAAGGTTGCCTTGCCATCCCTCGGCACCACAACTTCCCCCGCCCC
CCCATCGCCTCCTCCTCCATCCTCCAGTTCAAAATGGCGACGGCGGCGGCAGCGGCGGCGGTGATGGCTCCTCCGGGCTGCCCGGGTTCG
TGCCCCAACTTCGCCGTAGTCTGCTCCTTCTTGGAGCGCTACGGGCCGCTGCTAGACCTGCCTGAGTTGCCGTTCCCTGAGCTGGAGCGG
GTGCTGCAGGCGCCGCCGCCGGACGTCGGCAACGGAGAAGTACCAAAAGAATTGGTGGAGCTCCATTTGAAGCTGATGAGGAAAATTGGC
AAATCTGTTACTGCAGACAGATGGGAAAAATATTTGATCAAGATATGCCAAGAGTTTAACAGTACCTGGGCATGGGAGATGGAGAAGAAG
GGCTATCTTGAAATGAGTGTTGAATGCAAACTAGCACTCTTAAAGTACCTCTGTGAGTGTCAGTTTGATGACAATCTCAAATTCAAGAAT
ATTATTAATGAGGAGGATGCCGATACTATGCGTCTCCAGCCAATTGGTCGAGACAAAGATGGCCTCATGTACTGGTACCAATTGGATCAA
GATCACAATGTCAGAATGTACATAGAAGAACAAGATGATCAAGATGGCTCTTCATGGAAATGCATTGTCAGAAATCGAAACGAGTTGGCT
GAGACTCTTGCACTCCTGAAAGCACAAATTGATCCTGTACTATTGAAAAACTCTAGCCAACAAGACAACTCTTCTCGGGAAAGTCCCAGC
TTAGAGGATGAGGAGACTAAAAAAGAGGAAGAAACACCTAAACAAGGAAAGCCCAGTAGTTTCTTTCCAGAGGACAGTTTCATAGATTCT
GGAGAAATTGATGTGGGAAGGCGAGCTTCCCAGAAGATTCCTCCTGGCACTTTCTGGAGATCTCAAGTGTTCATAGACCATCCTGTGCAT
CTGAAATTCAATGTGTCTCTGGGAAAGGCAGCCCTGGTTGGCATTTATGGCAGAAAAGGCCTCCCTCCTTCACATACACAGTTTGACTTT
GTGGAGCTGCTGGATGGCAGGAGGCTCCTAACCCAGGAGGCGCGGAGCCTAGAGGGGACCCCGCGCCAGTCTCGGGGAACTGTGCCCCCC
TCCAGCCATGAGACAGGCTTCATCCAGTATTTGGATTCAGGAATCTGGCACTTGGCTTTTTACAATGACGGAAAGGAGTCAGAAGTGGTT
TCCTTTCTCACCACTGCCATTGAGTCGGTGGATAACTGCCCCAGCAACTGCTATGGCAATGGTGACTGCATCTCTGGGACCTGCCACTGC
TTCCTGGGTTTCCTGGGCCCCGACTGTGGCAGAGCCTCCTGCCCCGTGCTCTGTAGCGGAAATGGCCAATACATGAAAGGCAGATGCTTG
TGCCACAGTGGCTGGAAAGGCGCTGAGTGCGATGTGCCCACCAACCAGTGTATCGATGTGGCCTGCAGCAACCATGGCACCTGCATCACG
GGCACCTGCATCTGCAACCCTGGCTACAAGGGCGAGAGCTGTGAGGAAGTGGACTGCATGGACCCCACATGTTCAGGCCGGGGTGTCTGC
GTGAGAGGCGAATGCCACTGCTCTGTGGGATGGGGAGGCACCAACTGCGAGACCCCCAGGGCCACATGCTTAGACCAGTGTTCAGGCCAC
GGAACCTTCCTCCCGGACACCGGGCTTTGCAGCTGTGACCCAAGCTGGACTGGACACGACTGTTCTATCGAGATCTGTGCTGCCGACTGT
GGTGGCCATGGCGTGTGCGTAGGGGGCACCTGCCGCTGCGAGGATGGCTGGATGGGGGCAGCCTGCGACCAGCGGGCCTGCCACCCGCGC
TGTGCCGAGCATGGGACCTGCCGCGACGGCAAGTGCGAGTGCAGCCCTGGCTGGAATGGCGAACACTGCACCATCGCTCACTATCTGGAT
AGGGTAGTTAAAGAGGGTTGCCCTGGGTTGTGCAATGGCAACGGCAGATGTACCTTAGACCTGAATGGTTGGCACTGCGTCTGCCAGCTG
GGCTGGAGAGGAGCTGGCTGTGACACTTCCATGGAGACTGCCTGCGGTGACAGCAAAGACAATGATGGAGATGGCCTGGTGGACTGCATG
GACCCTGACTGCTGCCTCCAGCCCCTGTGCCATATCAACCCGCTGTGCCTTGGCTCCCCTAACCCTCTGGACATCATCCAGGAGACACAG
GTCCCTGTGTCACAGCAGAACCTACACTCCTTCTATGACCGCATCAAGTTCCTCGTGGGCAGGGACAGCACGCACATAATCCCCGGGGAG
AACCCCTTTGATGGAGGGCATGCTTGTGTTATTCGTGGCCAAGTGATGACATCAGATGGAACCCCCCTGGTTGGTGTGAACATCAGTTTT
GTCAATAACCCTCTCTTTGGATATACAATCAGCAGGCAAGATGGCAGCTTTGACTTGGTGACAAATGGCGGCATCTCCATCATCCTGCGG
TTCGAGCGGGCACCTTTCATCACACAGGAGCACACCCTGTGGCTGCCATGGGATCGCTTCTTTGTCATGGAAACCATCATCATGAGACAT
GAGGAGAATGAGATTCCCAGCTGTGACCTGAGCAATTTTGCCCGCCCCAACCCAGTCGTCTCTCCATCCCCACTGACGTCCTTCGCCAGC
TCCTGTGCAGAGAAAGGCCCCATTGTGCCGGAAATTCAGGCTTTGCAGGAGGAAATCTCTATCTCTGGCTGCAAGATGAGGCTGAGCTAC
CTGAGCAGCCGGACCCCTGGCTACAAATCTGTCCTGAGGATCAGCCTCACCCACCCGACCATCCCCTTCAACCTCATGAAGGTGCACCTC
ATGGTAGCGGTGGAGGGCCGCCTCTTCAGGAAGTGGTTCGCTGCAGCCCCAGACCTGTCCTATTATTTCATTTGGGACAAGACAGACGTC
TACAACCAGAAGGTGTTTGGGCTTTCAGAAGCCTTTGTTTCCGTGGGTTATGAATATGAATCCTGCCCAGATCTAATCCTGTGGGAAAAA
AGAACAACAGTGCTGCAGGGCTATGAAATTGACGCGTCCAAGCTTGGAGGATGGAGCCTAGACAAACATCATGCCCTCAACATTCAAAGT
GGCATCCTGCACAAAGGGAATGGGGAGAACCAGTTTGTGTCTCAGCAGCCTCCTGTCATTGGGAGCATCATGGGCAATGGGCGCCGGAGA
AGCATCTCCTGCCCCAGCTGCAACGGCCTTGCTGACGGCAACAAGCTCCTGGCCCCAGTGGCCCTCACCTGTGGCTCTGACGGGAGCCTC
TATGTGGGTGATTTCAACTACATTAGAAGGATCTTCCCCTCTGGAAATGTCACCAACATCCTAGAGCTGAGAAATAAAGATTTCAGACAT
AGTCACAGTCCAGCACACAAATACTACCTGGCCACAGACCCCATGAGTGGGGCCGTCTTCCTTTCTGACAGCAACAGCCGGCGGGTCTTT
AAAATCAAGTCCACTGTGGTGGTGAAGGACCTTGTCAAGAACTCTGAGGTGGTTGCGGGGACAGGTGACCAGTGCCTCCCCTTTGATGAC
ACTCGCTGCGGGGATGGTGGGAAGGCCACAGAAGCCACACTCACCAATCCCAGGGGCATTACAGTGGACAAGTTTGGGCTGATCTACTTC
GTGGATGGCACCATGATCAGACGCATCGATCAGAATGGGATCATCTCCACCCTGCTCGGCTCTAATGATCTCACATCAGCCCGGCCACTC
AGCTGTGATTCTGTCATGGATATTTCCCAGGTTCACCTGGAGTGGCCCACAGACTTAGCCATCAACCCAATGGACAACTCACTTTATGTC
CTCGACAACAATGTGGTCCTGCAAATCTCTGAAAACCACCAGGTGCGCATTGTCGCCGGGAGGCCCATGCACTGCCAGGTCCCTGGCATT
GACCACTTCCTGCTAAGCAAGGTGGCCATCCACGCAACCCTGGAGTCAGCCACCGCTTTGGCTGTTTCACACAATGGGGTCCTGTATATT
GCTGAGACTGATGAGAAAAAGATCAACCGCATCAGGCAGGTCACCACTAGTGGAGAGATCTCACTCGTTGCTGGGGCCCCCAGTGGCTGT
GACTGTAAAAATGATGCCAACTGTGATTGTTTTTCTGGAGACGATGGTTATGCCAAGGATGCAAAGTTAAATACCCCATCTTCCTTGGCT
GTGTGTGCTGATGGGGAGCTCTACGTGGCCGACCTTGGGAACATCCGAATTCGGTTTATCCGGAAGAACAAGCCTTTCCTCAACACCCAG
AACATGTATGAGCTGTCTTCACCAATTGACCAGGAGCTCTATCTGTTTGATACCACCGGCAAGCACCTGTACACCCAAAGCCTGCCCACA
GGAGACTACCTGTACAACTTCACCTACACTGGGGACGGCGACATCACACTCATCACAGACAACAATGGCAACATGGTAAATGTCCGCCGA
GACTCTACTGGGATGCCCCTCTGGCTGGTGGTCCCAGATGGCCAGGTGTACTGGGTGACCATGGGCACCAACAGTGCACTCAAGAGTGTG
ACCACACAAGGACACGAGTTGGCCATGATGACATACCATGGCAATTCCGGCCTTCTGGCAACCAAAAGCAATGAAAACGGATGGACAACA
TTTTATGAGTACGACAGCTTTGGCCGCCTGACAAATGTGACCTTCCCTACTGGCCAGGTGAGCAGTTTCCGAAGTGATACAGACAGTTCA
GTGCATGTCCAGGTAGAGACCTCCAGCAAGGATGATGTCACCATAACCACCAACCTGTCTGCCTCAGGCGCCTTCTACACACTGCTGCAA
GACCAAGTCCGGAACAGCTACTACATCGGGGCCGATGGCTCCTTGCGGCTGCTGCTGGCCAACGGCATGGAGGTGGCGCTGCAGACTGAG
CCCCACTTGCTGGCTGGCACCGTCAACCCCACCGTGGGCAAGAGGAATGTCACGCTGCCCATCGACAACGGCCTCAACCTGGTGGAGTGG
CGCCAGCGCAAAGAGCAGGCTCGGGGCCAGGTCACTGTCTTTGGGCGCCGGCTGCGGGTTCACAACCGAAATCTCCTATCTCTGGACTTT
GATCGCGTAACACGCACAGAGAAGATCTATGATGACCACCGCAAGTTCACCCTTCGGATTCTGTACGACCAGGCGGGGCGGCCCAGCCTC
TGGTCACCCAGCAGCAGGCTGAATGGTGTCAACGTGACATACTCCCCTGGGGGTTACATTGCTGGCATCCAGAGGGGCATCATGTCTGAA
AGAATGGAATACGACCAGGCGGGCCGCATCACATCCAGGATCTTCGCTGATGGGAAGACATGGAGCTACACATACTTAGAGAAGTCCATG
GTGCTGCTACTACACAGCCAGAGGCAGTATATCTTTGAGTTCGACAAGAATGACCGCCTCTCTTCTGTGACGATGCCCAACGTGGCGCGG
CAGACACTAGAGACCATCCGCTCAGTGGGCTACTACAGAAACATCTATCAGCCCCCTGAGGGCAATGCCTCAGTCATACAGGACTTCACT
GAGGATGGGCACCTCCTTCACACCTTCTACCTGGGCACTGGCCGCAGGGTGATATACAAGTATGGCAAACTGTCAAAGCTGGCAGAGACG
CTCTATGACACCACCAAGGTCAGTTTCACCTATGACGAGACGGCAGGCATGCTGAAGACCATCAACCTACAGAATGAGGGCTTCACCTGC
ACCATCCGCTACCGTCAGATTGGGCCCCTGATTGACCGACAGATCTTCCGCTTCACTGAGGAAGGCATGGTCAACGCCCGTTTTGACTAC
AACTATGACAACAGCTTCCGGGTGACCAGCATGCAGGCTGTGATCAACGAGACCCCACTGCCCATTGATCTCTATCGCTATGATGATGTG
TCAGGCAAGACAGAGCAGTTTGGGAAGTTTGGTGTCATTTACTATGACATTAACCAGATCATCACCACAGCTGTCATGACCCACACCAAG
CATTTTGATGCATATGGCAGGATGAAGGAAGTGCAGTATGAGATCTTCCGCTCGCTCATGTACTGGATGACCGTCCAGTATGATAACATG
GGGCGAGTAGTGAAGAAGGAGCTGAAGGTAGGACCCTACGCCAATACCACTCGCTACTCCTATGAGTATGATGCTGACGGCCAGCTGCAG
ACAGTCTCCATCAATGACAAGCCACTCTGGCGCTACAGCTACGACCTCAATGGGAACCTGCACTTACTGAGCCCTGGGAACAGTGCACGG
CTCACACCACTACGGTATGACATCCGCGACCGCATCACTCGGCTGGGTGACGTGCAATACAAGATGGATGAGGATGGCTTCCTGAGGCAG
CGGGGCGGTGATATCTTTGAGTACAACTCAGCTGGCCTGCTCATCAAGGCCTACAACCGGGCTGGCAGCTGGAGTGTCAGGTACCGCTAC
GATGGCCTGGGGCGGCGCGTGTCCAGCAAGAGCAGCCACAGCCACCACCTGCAGTTCTTCTATGCAGACCTGACCAACCCCACCAAGGTC
ACCCACCTGTACAACCACTCCAGCTCTGAGATCACCTCCCTCTACTACGACTTGCAAGGACACCTCTTTGCCATGGAGCTGAGCAGTGGT
GATGAGTTTTACATAGCTTGTGACAACATCGGGACCCCTCTTGCTGTCTTTAGTGGAACAGGTTTGATGATCAAGCAAATCCTGTACACA
GCCTATGGGGAGATCTACATGGATACCAACCCCAACTTTCAGATCATCATAGGCTACCATGGTGGCCTCTATGATCCACTCACCAAGCTT
GTCCACATGGGCCGGCGAGATTATGATGTGCTGGCCGGACGCTGGACTAGCCCAGACCACGAGCTGTGGAAGCACCTTAGTAGCAGCAAC
GTCATGCCTTTTAATCTCTATATGTTCAAAAACAACAACCCCATCAGCAACTCCCAGGACATCAAGTGCTTCATGACAGATGTTAACAGC
TGGCTGCTCACCTTTGGATTCCAGCTACACAACGTGATCCCTGGTTATCCCAAACCAGACATGGATGCCATGGAACCCTCCTACGAGCTC
ATCCACACACAGATGAAAACGCAGGAGTGGGACAACAGCAAGTCTATCCTCGGGGTACAGTGTGAAGTACAGAAGCAGCTCAAGGCCTTT
GTCACCTTAGAACGGTTTGACCAGCTCTATGGCTCCACAATCACCAGCTGCCAGCAGGCTCCAAAGACCAAGAAGTTTGCATCCAGCGGC
TCAGTCTTTGGCAAGGGGGTCAAGTTTGCCTTGAAGGATGGCCGAGTGACCACAGACATCATCAGTGTGGCCAATGAGGATGGGCGAAGG
GTTGCTGCCATCTTGAACCATGCCCACTACCTAGAGAACCTGCACTTCACCATTGATGGGGTGGATACCCATTACTTTGTGAAACCAGGA
CCTTCAGAAGGTGACCTGGCCATCCTGGGCCTCAGTGGGGGGCGGCGAACCCTGGAGAATGGGGTCAACGTCACTGTGTCCCAGATCAAC
ACAGTACTTAATGGCAGGACTAGACGCTACACAGACATCCAGCTCCAGTACGGGGCACTGTGCTTGAACACACGCTACGGGACAACGTTG
GATGAGGAGAAGGCACGGGTCCTGGAGCTGGCCCGGCAGAGAGCCGTGCGCCAAGCGTGGGCCCGCGAGCAGCAGAGACTGCGGGAAGGG
GAGGAAGGCCTGCGGGCCTGGACAGAGGGGGAGAAGCAGCAGGTGCTGAGCACAGGGCGGGTGCAAGGCTACGACGGCTTTTTCGTGATC
TCTGTCGAGCAGTACCCAGAACTGTCAGACAGCGCCAACAACATCCACTTCATGAGACAGAGCGAGATGGGCCGGAGGTGACAGAGAGGA
CCAAGGACTTCTTGCCAAAGACAGCTACTCTTTTGTGGCCGCATACCTGACTGTGTTGTACTTTTAAAAAAATGATTTTTTAACAAGTGC
AGAAACAAAAAGATACTGGTTGCATTGTAACTCATGCAACATCCTTTTTTTTAGAAAAGAAAAACACAGATTTGGCCTTCGCACATTTTT
TGCAAAGAACAGAAGGTATTTTTTTCTGTAGTGTGATCACAATGAAAACTTTATTGTCTTTTGTTCCCTTTTTCCTTGAGGATTTTTCCC
TTGTCGTTTGGGGTATGTATCTCCTCTCTGAGATGCATCTCCTGGGGTGTGTCCTCGTCTGTCCCTAGGTACCCAGTGTGATGTGGGACA
TGAATGTCTGTGCTAACTTGTCTCATGTGCAACCCTTTCTTCTTCGACTGGGGTCGGGCAGGAGTAAAGGGAGTGATGGGCCAGTACAAC
ACCCCTTCCAAGGGGGCCTGGGAGGAGGGTCTGTAGGACCTGAGGCTCCTTGGCAGGGCTCCTGCAGAAGAGTGGTGGATTTCTTCTCAC
CTTGTTCTCTGCCTCCAGAGGATCATAGATGGCTTCATCTTGCTCCAGGGAATTTCATGGTGTTGTTCAGCACCTTTTTTAAGCTGCCCC
AAACTCCTGTTCAAGCTTTCTATTTTGATGCTGAATGAAACCCCCTACCACTTTTGCAAATCCTGTGTAGTTGTCGGTGCCACCCCCATG
CTGGGATAGAGAAAGTGTCTCCCAGGTCCTTTCCCCCAGACCAGTGACATAACATCCTGGGCTCAGAGTCCCATCCTCCCGGGAGGGAAA
GCACCCAGGATGCCTGTGATTGGTTGGTCCTCCATGATGTTCCTGTTCATCTCCTCCTTTCTCCCAAAGCCAGATGTGAGAACGAGCACT
GCACAGCAAGCCTTCAATGTGGGCACCATGTCCACAGAACAGAAGGCCACCCATGGCAAAGGCATGGCAGTGGTGGCGAGGGCACCAGCC
TGCCTTCCGAGGCAAAGCCCTCTCTCTATGACTTTGAGTATCTTCCCTCCACCACTCAGCCGCCACCACTGAGACGTAGGAATGTGGAGG
GAGGTGCTTGGTGGCCTTTGATTCTGGAAAAATGCTTAACAAAAAAAGCCAGCCAAAGAGAGGAAGGCATAAGCTAAGCATCCTTCTAAC
CAGTTCCCAAAGTCCCATCTGCCTCCATGTACCAGCTGATCGCAGAGCTGGACTGGGGCAGGCTGGGCTTCCAGGAAATTCCTGAAGTTC
TGAAACAGCTTCCCCTCTAGAGAAGCCCACCCAATGTGTTTTTTAGTGACAGGAAGAAAGGAGGGAAGAGCTGATGTGGTGTGGCCTGCC
CATATCATACAACCCCACCAGGAGCAGGGCAGTTCCCAAGGTGGGTGCCCGTAGATCTGGGAGGCCAGGCTGGCATGATTCCTGTGAAGA
ACTGTGCCTGTGTCGTCAGGGAGAGGCCTGAGCCCTCTCAGAAGCAGGGACAGCCCACACCTGAAGAGCACGCCCAAGCTGAGGCAGCAG
CCAGCAGGCTGGGGGAGCAGTGAGGGCAGGGGGAGTCACAGCCAGAGCTGGGAGCCCCTTGTTCAAGGATTCCATTCCTGGTTCATCCGC
CTAATTACCATTGTCATTACCACTCACAGGAGGCTCTGGGAGATGGGAGGGGAAGCCAAATGCTTCCTTTTAAGCTGGGCTTCTTAGAAA
ATGGAACTTTTATGGGTTACATTTACATTAAGTGTGGAAAATGAATTCTGAGTCTGAGCTATTCCCCGTGGAAACCTTGTTGGACTGATA
AGCTCATGGCACCTCTATAGCCTTACTCACATAGTCTTCAGAATATTACACAAGTTAATGAAACTGAGAAGGTCTGACTGCATGAGGATC
GGAGCAGCATGTAGTCTGGGTTCTGCCTGGCAGAGGGAGGCAACCAAAACTTCTTGGGGAGAGGAGATTTCGCCTTAACGTCATCCCACT
GGGATTAGAGGATGTGTTTCGCTAAGTGCTCTTCCTGTTTCCAAAAAAAAAGCCACCCTGCTGCAGCAGTGCGCTTTGGCCTGCTTGTCC
ACTGGTTGCCCATTGCCCCTGGATCCAGAGCTCTACTGAGTCAGATACAGTGCTCTGCAGGCCTGCTGTGGGAGGCATGAGCTGGAGATG
GGGGCTCCCATCTGGCAGGATCATTCTTGGATGAGATGGAAAACAGTTTGGCCTGAAGAACACAAGTTTTGTCCTCCAGAAGGGACTTAC
GCCTCTCAAAATGTACTCTTCATACCAAGGGCCCTTGGGCAAAGTGCTCCTGCCCAGTTGATCAGTCCCATCCTGGCTGCCTGACATCAG
TGAAGACCTGCTGGGGATGTCTGCTCAGAGGTCAGGAACGGCATGCGGTCCACAGGAACCAGCTCCCTACGCTTCCCCCACGCCCTGTCC
CTCCTCCACAGCCCCCTCCCCAAAGGAATAGGGTGGACTTTTAGGGATCAAAAACAGAATTATTGGGTGTTTCATTTATTTTTTTCTTTC
TTTCTTTTTTTTTTCATAGAGATGGGGTCTCACTATGTTGCCCAGGCTGTTCTCAAACTCCTGGCCTCAGGCGATCCACCTTGGCCTCCT
GAAGTGCTGGGGTTACAGGTGTGAGCCACTGCGCCTGGACTGAGTGTTTGTTTCTTTAAAGGATCTTATATTTTTCCTGTGCTACATACC
ACCACAGCAGCCCAGCTTCTGTGGGGAGAGAAGTTGAAGGATCCCGAAGCTTTAGAAAAAGGATCTCAGCTGTGGCACAGGCAGTGTTAT
GCGCCTCACTGCCACATTGGTGCTGTTGTATTGAAGGTGGTGCTTCTGGCCTTGGCCCTTTTGAGTTGGTTTCCATTTGGGCTGCAGGTG
ACTCAGTGACTCCCTCCTCAAGCTGTCCTCCTGCTAAGACCAGCAGTCACAAACCCATGGCAAGGGTGAGTGTGAAGGCCTAACCCTGTG
CCTATGTAATAGGCTCCAAGCATCGACTCCCATCCTGAGAGGACCGGCCCTTTTGACACTCACCAACCAAATCTGTTCATTCGATAGAGT
GACCAGGCCTCCCTCACCTGCCCAGGTGTATGATCCTACAGTTCCTGCCTTCTCTCCTACCCCGCACAGCTGCCAACTGGTCCTACATCC
TCAGCCCCTCTGCCACCACCTTAAATAGGACTTTACTGATTCCCCAACTTTGTTTTTTTGTAGGATGAGATTTCCTTTTTATCCCACCCC
CCCACACCCCAAACAGACATTGCTGGAGGGCAGACTGGAGGAAGGGGAAGGCATGCAGGTAAATTACTGCCTTGTCAGCCTCTGACCCTC
ATCTCTCAGAATTGTTGGCTGAGAATTAACCCAAGGACCACACCAGTGCCTGATTTCTACTTAGGGAGAGAGGATTGGAAACGATCCCTA
AGAAACTGACTGAGGGTGAGAATGGCCAGGAGGTGTGTGTCCAAATAACCAGGAGGGGGCACAGAAGATGATGGCAAGGCAGACTGGGCA
GTGTTTTGTAGACACAGAACAAAGAATCAGAATTTGAAAAAAGAAGAAAAACAAATCTTCGCAGCTGCAACTTTAAAGTATCACCTTTAT
AGATGGCAGGGATTTCCATTATGCAAATGGAATCTAAGATTTCAATGTGAAATCTTAGAATGCAGTTTTACCACTTGCAGTCTTGTATTT
GTGGTGGCCATGTGGTGAGGGCGGTGATGCTGAGCTTTCTGCCCAGGAGGAATGAGCTTTCAAGCTCTCAGCAGGGTGTCAGGCTTGGGG
ATTTGAGCATCCACTGCTCAAAGTCCAGGCTATTCTCCAGTCCTCACGGCAGCCACTAAGCCCAGGAGCCAGACCTGGCCCGGGGACACA
TCTCCTGAGGGATCCCAGAAAGAACCCAGTCTTTCCTTTCCCTTGGGGTCCTTGTTAGAATGAAAACCTCTCTATTTAAGGCACATCATT
CCCAGCTAGGTTTATACACTTGTCTATATTTTACTGGAGGAAAGGGAATTAAAAAAGAACTCTGCAGTTCAAGGCCCTTTCATTTAACCT
TCCAAAAACAGCAAACTCATTTTAAAGACTCATTGCTGAGGTGATAGAGAGAAACCTTATCCTCTCCAACCTTCACATTCACAAAAACCA
TCCTTGTGTACTTGACTGCCCTAGACAGTGGTGACTCTTAGGTTTCATTACGAATGTGGAATATCAGAGTGTGGGAAGGCCCAGGCGAGG
GCCAATGTTGTGTTTCTTACCCCCTCTGGAATGCCAAAGGCAAGGTACTAGGTGACCTCCTGGTCCCCAAGAAAATGTGATTTATTCTGA
GGGCGAACAGCCAAGGGAGGACTAGTCTGGAGCACGCTCGGCCGTCCTGGCAGGAGCTGAGCCTCAGGTGTCTGGCGGTGCCCCAGCAGC
CCTGGATTCACCCAACACCAGAATCCCACTTTTCTAAATCCACCTGTTGTTCTGAGCACCTCTGAACCCGCAGCTTCGGCAAAAGGAGTC
TGTACCAAGCTGCTTCTGGATGACCAACACTGGAGACTCTGGCCTTACCATGTGGAAATCATTTTCCTGAAGTCTGGAACTAATTTTGAG
AAGTTTTTTTCTCAACACTTTTGTGTTTCTAACACTGTATCTTGACTGTGTAAATACCAACAAGGCTGTAAATAAATGCAGATGTAGATA
CCTTCTAGAAAAAAAAAAGCATAAAAACAAAACCAGAAGTGATCCCGTGTAGCCTTCGTTGACAAATAAAGACTATTTTGTGTTTACAGG
TGTCTGGTGGCCTTTGCTTGGAGATAAAGGCTTCCTCTTGCCTGTCCCAGCCCCCGAGCCATCCTGGGTTTGCACTTCCCTGCTGGCTGC
TATCAGGATGACCTGGGAGAGGACTCAGTCCTAGGCCCCAGGGTCCCTCTAAATCCCTCCAGGCTGCAGCTCTGTCAAGAGGGATGTCCA
GAGGGTCTCTAAGACCCTGAAGCTTGACTTTGCAATTGCATGACAGGAATAAATATCACAGCTCCTCTGACATCACTAGTGCAGCGTGGC
TCCCCATCCCACTGCTGCCCTCGTTCAGGGACAGGCTGAAGGGGCCAACGAACCCAACCCTCCCAGAGGAGGGAGCCTTGCTCCACCACT

>78414_78414_1_RSF1-TENM4_RSF1_chr11_77436590_ENST00000308488_TENM4_chr11_78567223_ENST00000278550_length(amino acids)=2595AA_BP=236
MATAAAAAAVMAPPGCPGSCPNFAVVCSFLERYGPLLDLPELPFPELERVLQAPPPDVGNGEVPKELVELHLKLMRKIGKSVTADRWEKY
LIKICQEFNSTWAWEMEKKGYLEMSVECKLALLKYLCECQFDDNLKFKNIINEEDADTMRLQPIGRDKDGLMYWYQLDQDHNVRMYIEEQ
DDQDGSSWKCIVRNRNELAETLALLKAQIDPVLLKNSSQQDNSSRESPSLEDEETKKEEETPKQGKPSSFFPEDSFIDSGEIDVGRRASQ
KIPPGTFWRSQVFIDHPVHLKFNVSLGKAALVGIYGRKGLPPSHTQFDFVELLDGRRLLTQEARSLEGTPRQSRGTVPPSSHETGFIQYL
DSGIWHLAFYNDGKESEVVSFLTTAIESVDNCPSNCYGNGDCISGTCHCFLGFLGPDCGRASCPVLCSGNGQYMKGRCLCHSGWKGAECD
VPTNQCIDVACSNHGTCITGTCICNPGYKGESCEEVDCMDPTCSGRGVCVRGECHCSVGWGGTNCETPRATCLDQCSGHGTFLPDTGLCS
CDPSWTGHDCSIEICAADCGGHGVCVGGTCRCEDGWMGAACDQRACHPRCAEHGTCRDGKCECSPGWNGEHCTIAHYLDRVVKEGCPGLC
NGNGRCTLDLNGWHCVCQLGWRGAGCDTSMETACGDSKDNDGDGLVDCMDPDCCLQPLCHINPLCLGSPNPLDIIQETQVPVSQQNLHSF
YDRIKFLVGRDSTHIIPGENPFDGGHACVIRGQVMTSDGTPLVGVNISFVNNPLFGYTISRQDGSFDLVTNGGISIILRFERAPFITQEH
TLWLPWDRFFVMETIIMRHEENEIPSCDLSNFARPNPVVSPSPLTSFASSCAEKGPIVPEIQALQEEISISGCKMRLSYLSSRTPGYKSV
LRISLTHPTIPFNLMKVHLMVAVEGRLFRKWFAAAPDLSYYFIWDKTDVYNQKVFGLSEAFVSVGYEYESCPDLILWEKRTTVLQGYEID
ASKLGGWSLDKHHALNIQSGILHKGNGENQFVSQQPPVIGSIMGNGRRRSISCPSCNGLADGNKLLAPVALTCGSDGSLYVGDFNYIRRI
FPSGNVTNILELRNKDFRHSHSPAHKYYLATDPMSGAVFLSDSNSRRVFKIKSTVVVKDLVKNSEVVAGTGDQCLPFDDTRCGDGGKATE
ATLTNPRGITVDKFGLIYFVDGTMIRRIDQNGIISTLLGSNDLTSARPLSCDSVMDISQVHLEWPTDLAINPMDNSLYVLDNNVVLQISE
NHQVRIVAGRPMHCQVPGIDHFLLSKVAIHATLESATALAVSHNGVLYIAETDEKKINRIRQVTTSGEISLVAGAPSGCDCKNDANCDCF
SGDDGYAKDAKLNTPSSLAVCADGELYVADLGNIRIRFIRKNKPFLNTQNMYELSSPIDQELYLFDTTGKHLYTQSLPTGDYLYNFTYTG
DGDITLITDNNGNMVNVRRDSTGMPLWLVVPDGQVYWVTMGTNSALKSVTTQGHELAMMTYHGNSGLLATKSNENGWTTFYEYDSFGRLT
NVTFPTGQVSSFRSDTDSSVHVQVETSSKDDVTITTNLSASGAFYTLLQDQVRNSYYIGADGSLRLLLANGMEVALQTEPHLLAGTVNPT
VGKRNVTLPIDNGLNLVEWRQRKEQARGQVTVFGRRLRVHNRNLLSLDFDRVTRTEKIYDDHRKFTLRILYDQAGRPSLWSPSSRLNGVN
VTYSPGGYIAGIQRGIMSERMEYDQAGRITSRIFADGKTWSYTYLEKSMVLLLHSQRQYIFEFDKNDRLSSVTMPNVARQTLETIRSVGY
YRNIYQPPEGNASVIQDFTEDGHLLHTFYLGTGRRVIYKYGKLSKLAETLYDTTKVSFTYDETAGMLKTINLQNEGFTCTIRYRQIGPLI
DRQIFRFTEEGMVNARFDYNYDNSFRVTSMQAVINETPLPIDLYRYDDVSGKTEQFGKFGVIYYDINQIITTAVMTHTKHFDAYGRMKEV
QYEIFRSLMYWMTVQYDNMGRVVKKELKVGPYANTTRYSYEYDADGQLQTVSINDKPLWRYSYDLNGNLHLLSPGNSARLTPLRYDIRDR
ITRLGDVQYKMDEDGFLRQRGGDIFEYNSAGLLIKAYNRAGSWSVRYRYDGLGRRVSSKSSHSHHLQFFYADLTNPTKVTHLYNHSSSEI
TSLYYDLQGHLFAMELSSGDEFYIACDNIGTPLAVFSGTGLMIKQILYTAYGEIYMDTNPNFQIIIGYHGGLYDPLTKLVHMGRRDYDVL
AGRWTSPDHELWKHLSSSNVMPFNLYMFKNNNPISNSQDIKCFMTDVNSWLLTFGFQLHNVIPGYPKPDMDAMEPSYELIHTQMKTQEWD
NSKSILGVQCEVQKQLKAFVTLERFDQLYGSTITSCQQAPKTKKFASSGSVFGKGVKFALKDGRVTTDIISVANEDGRRVAAILNHAHYL
ENLHFTIDGVDTHYFVKPGPSEGDLAILGLSGGRRTLENGVNVTVSQINTVLNGRTRRYTDIQLQYGALCLNTRYGTTLDEEKARVLELA

--------------------------------------------------------------
>78414_78414_2_RSF1-TENM4_RSF1_chr11_77436590_ENST00000360355_TENM4_chr11_78567223_ENST00000278550_length(transcript)=13042nt_BP=760nt
GATCCGCAGAGGAGCCCACTTGAGAGCGCCTCCTGTCGTCTGTAAGGTTGCCTTGCCATCCCTCGGCACCACAACTTCCCCCGCCCCCCC
ATCGCCTCCTCCTCCATCCTCCAGTTCAAAATGGCGACGGCGGCGGCAGCGGCGGCGGTGATGGCTCCTCCGGGCTGCCCGGGTTCGTGC
CCCAACTTCGCCGTAGTCTGCTCCTTCTTGGAGCGCTACGGGCCGCTGCTAGACCTGCCTGAGTTGCCGTTCCCTGAGCTGGAGCGGGTG
CTGCAGGCGCCGCCGCCGGACGTCGGCAACGGAGAAGTACCAAAAGAATTGGTGGAGCTCCATTTGAAGCTGATGAGGAAAATTGGCAAA
TCTGTTACTGCAGACAGATGGGAAAAATATTTGATCAAGTACCTCTGTGAGTGTCAGTTTGATGACAATCTCAAATTCAAGAATATTATT
AATGAGGAGGATGCCGATACTATGCGTCTCCAGCCAATTGGTCGAGACAAAGATGGCCTCATGTACTGGTACCAATTGGATCAAGATCAC
AATGTCAGAATGTACATAGAAGAACAAGATGATCAAGATGGCTCTTCATGGAAATGCATTGTCAGAAATCGAAACGAGTTGGCTGAGACT
CTTGCACTCCTGAAAGCACAAATTGATCCTGTACTATTGAAAAACTCTAGCCAACAAGACAACTCTTCTCGGGAAAGTCCCAGCTTAGAG
GATGAGGAGACTAAAAAAGAGGAAGAAACACCTAAACAAGGAAAGCCCAGTAGTTTCTTTCCAGAGGACAGTTTCATAGATTCTGGAGAA
ATTGATGTGGGAAGGCGAGCTTCCCAGAAGATTCCTCCTGGCACTTTCTGGAGATCTCAAGTGTTCATAGACCATCCTGTGCATCTGAAA
TTCAATGTGTCTCTGGGAAAGGCAGCCCTGGTTGGCATTTATGGCAGAAAAGGCCTCCCTCCTTCACATACACAGTTTGACTTTGTGGAG
CTGCTGGATGGCAGGAGGCTCCTAACCCAGGAGGCGCGGAGCCTAGAGGGGACCCCGCGCCAGTCTCGGGGAACTGTGCCCCCCTCCAGC
CATGAGACAGGCTTCATCCAGTATTTGGATTCAGGAATCTGGCACTTGGCTTTTTACAATGACGGAAAGGAGTCAGAAGTGGTTTCCTTT
CTCACCACTGCCATTGAGTCGGTGGATAACTGCCCCAGCAACTGCTATGGCAATGGTGACTGCATCTCTGGGACCTGCCACTGCTTCCTG
GGTTTCCTGGGCCCCGACTGTGGCAGAGCCTCCTGCCCCGTGCTCTGTAGCGGAAATGGCCAATACATGAAAGGCAGATGCTTGTGCCAC
AGTGGCTGGAAAGGCGCTGAGTGCGATGTGCCCACCAACCAGTGTATCGATGTGGCCTGCAGCAACCATGGCACCTGCATCACGGGCACC
TGCATCTGCAACCCTGGCTACAAGGGCGAGAGCTGTGAGGAAGTGGACTGCATGGACCCCACATGTTCAGGCCGGGGTGTCTGCGTGAGA
GGCGAATGCCACTGCTCTGTGGGATGGGGAGGCACCAACTGCGAGACCCCCAGGGCCACATGCTTAGACCAGTGTTCAGGCCACGGAACC
TTCCTCCCGGACACCGGGCTTTGCAGCTGTGACCCAAGCTGGACTGGACACGACTGTTCTATCGAGATCTGTGCTGCCGACTGTGGTGGC
CATGGCGTGTGCGTAGGGGGCACCTGCCGCTGCGAGGATGGCTGGATGGGGGCAGCCTGCGACCAGCGGGCCTGCCACCCGCGCTGTGCC
GAGCATGGGACCTGCCGCGACGGCAAGTGCGAGTGCAGCCCTGGCTGGAATGGCGAACACTGCACCATCGCTCACTATCTGGATAGGGTA
GTTAAAGAGGGTTGCCCTGGGTTGTGCAATGGCAACGGCAGATGTACCTTAGACCTGAATGGTTGGCACTGCGTCTGCCAGCTGGGCTGG
AGAGGAGCTGGCTGTGACACTTCCATGGAGACTGCCTGCGGTGACAGCAAAGACAATGATGGAGATGGCCTGGTGGACTGCATGGACCCT
GACTGCTGCCTCCAGCCCCTGTGCCATATCAACCCGCTGTGCCTTGGCTCCCCTAACCCTCTGGACATCATCCAGGAGACACAGGTCCCT
GTGTCACAGCAGAACCTACACTCCTTCTATGACCGCATCAAGTTCCTCGTGGGCAGGGACAGCACGCACATAATCCCCGGGGAGAACCCC
TTTGATGGAGGGCATGCTTGTGTTATTCGTGGCCAAGTGATGACATCAGATGGAACCCCCCTGGTTGGTGTGAACATCAGTTTTGTCAAT
AACCCTCTCTTTGGATATACAATCAGCAGGCAAGATGGCAGCTTTGACTTGGTGACAAATGGCGGCATCTCCATCATCCTGCGGTTCGAG
CGGGCACCTTTCATCACACAGGAGCACACCCTGTGGCTGCCATGGGATCGCTTCTTTGTCATGGAAACCATCATCATGAGACATGAGGAG
AATGAGATTCCCAGCTGTGACCTGAGCAATTTTGCCCGCCCCAACCCAGTCGTCTCTCCATCCCCACTGACGTCCTTCGCCAGCTCCTGT
GCAGAGAAAGGCCCCATTGTGCCGGAAATTCAGGCTTTGCAGGAGGAAATCTCTATCTCTGGCTGCAAGATGAGGCTGAGCTACCTGAGC
AGCCGGACCCCTGGCTACAAATCTGTCCTGAGGATCAGCCTCACCCACCCGACCATCCCCTTCAACCTCATGAAGGTGCACCTCATGGTA
GCGGTGGAGGGCCGCCTCTTCAGGAAGTGGTTCGCTGCAGCCCCAGACCTGTCCTATTATTTCATTTGGGACAAGACAGACGTCTACAAC
CAGAAGGTGTTTGGGCTTTCAGAAGCCTTTGTTTCCGTGGGTTATGAATATGAATCCTGCCCAGATCTAATCCTGTGGGAAAAAAGAACA
ACAGTGCTGCAGGGCTATGAAATTGACGCGTCCAAGCTTGGAGGATGGAGCCTAGACAAACATCATGCCCTCAACATTCAAAGTGGCATC
CTGCACAAAGGGAATGGGGAGAACCAGTTTGTGTCTCAGCAGCCTCCTGTCATTGGGAGCATCATGGGCAATGGGCGCCGGAGAAGCATC
TCCTGCCCCAGCTGCAACGGCCTTGCTGACGGCAACAAGCTCCTGGCCCCAGTGGCCCTCACCTGTGGCTCTGACGGGAGCCTCTATGTG
GGTGATTTCAACTACATTAGAAGGATCTTCCCCTCTGGAAATGTCACCAACATCCTAGAGCTGAGAAATAAAGATTTCAGACATAGTCAC
AGTCCAGCACACAAATACTACCTGGCCACAGACCCCATGAGTGGGGCCGTCTTCCTTTCTGACAGCAACAGCCGGCGGGTCTTTAAAATC
AAGTCCACTGTGGTGGTGAAGGACCTTGTCAAGAACTCTGAGGTGGTTGCGGGGACAGGTGACCAGTGCCTCCCCTTTGATGACACTCGC
TGCGGGGATGGTGGGAAGGCCACAGAAGCCACACTCACCAATCCCAGGGGCATTACAGTGGACAAGTTTGGGCTGATCTACTTCGTGGAT
GGCACCATGATCAGACGCATCGATCAGAATGGGATCATCTCCACCCTGCTCGGCTCTAATGATCTCACATCAGCCCGGCCACTCAGCTGT
GATTCTGTCATGGATATTTCCCAGGTTCACCTGGAGTGGCCCACAGACTTAGCCATCAACCCAATGGACAACTCACTTTATGTCCTCGAC
AACAATGTGGTCCTGCAAATCTCTGAAAACCACCAGGTGCGCATTGTCGCCGGGAGGCCCATGCACTGCCAGGTCCCTGGCATTGACCAC
TTCCTGCTAAGCAAGGTGGCCATCCACGCAACCCTGGAGTCAGCCACCGCTTTGGCTGTTTCACACAATGGGGTCCTGTATATTGCTGAG
ACTGATGAGAAAAAGATCAACCGCATCAGGCAGGTCACCACTAGTGGAGAGATCTCACTCGTTGCTGGGGCCCCCAGTGGCTGTGACTGT
AAAAATGATGCCAACTGTGATTGTTTTTCTGGAGACGATGGTTATGCCAAGGATGCAAAGTTAAATACCCCATCTTCCTTGGCTGTGTGT
GCTGATGGGGAGCTCTACGTGGCCGACCTTGGGAACATCCGAATTCGGTTTATCCGGAAGAACAAGCCTTTCCTCAACACCCAGAACATG
TATGAGCTGTCTTCACCAATTGACCAGGAGCTCTATCTGTTTGATACCACCGGCAAGCACCTGTACACCCAAAGCCTGCCCACAGGAGAC
TACCTGTACAACTTCACCTACACTGGGGACGGCGACATCACACTCATCACAGACAACAATGGCAACATGGTAAATGTCCGCCGAGACTCT
ACTGGGATGCCCCTCTGGCTGGTGGTCCCAGATGGCCAGGTGTACTGGGTGACCATGGGCACCAACAGTGCACTCAAGAGTGTGACCACA
CAAGGACACGAGTTGGCCATGATGACATACCATGGCAATTCCGGCCTTCTGGCAACCAAAAGCAATGAAAACGGATGGACAACATTTTAT
GAGTACGACAGCTTTGGCCGCCTGACAAATGTGACCTTCCCTACTGGCCAGGTGAGCAGTTTCCGAAGTGATACAGACAGTTCAGTGCAT
GTCCAGGTAGAGACCTCCAGCAAGGATGATGTCACCATAACCACCAACCTGTCTGCCTCAGGCGCCTTCTACACACTGCTGCAAGACCAA
GTCCGGAACAGCTACTACATCGGGGCCGATGGCTCCTTGCGGCTGCTGCTGGCCAACGGCATGGAGGTGGCGCTGCAGACTGAGCCCCAC
TTGCTGGCTGGCACCGTCAACCCCACCGTGGGCAAGAGGAATGTCACGCTGCCCATCGACAACGGCCTCAACCTGGTGGAGTGGCGCCAG
CGCAAAGAGCAGGCTCGGGGCCAGGTCACTGTCTTTGGGCGCCGGCTGCGGGTTCACAACCGAAATCTCCTATCTCTGGACTTTGATCGC
GTAACACGCACAGAGAAGATCTATGATGACCACCGCAAGTTCACCCTTCGGATTCTGTACGACCAGGCGGGGCGGCCCAGCCTCTGGTCA
CCCAGCAGCAGGCTGAATGGTGTCAACGTGACATACTCCCCTGGGGGTTACATTGCTGGCATCCAGAGGGGCATCATGTCTGAAAGAATG
GAATACGACCAGGCGGGCCGCATCACATCCAGGATCTTCGCTGATGGGAAGACATGGAGCTACACATACTTAGAGAAGTCCATGGTGCTG
CTACTACACAGCCAGAGGCAGTATATCTTTGAGTTCGACAAGAATGACCGCCTCTCTTCTGTGACGATGCCCAACGTGGCGCGGCAGACA
CTAGAGACCATCCGCTCAGTGGGCTACTACAGAAACATCTATCAGCCCCCTGAGGGCAATGCCTCAGTCATACAGGACTTCACTGAGGAT
GGGCACCTCCTTCACACCTTCTACCTGGGCACTGGCCGCAGGGTGATATACAAGTATGGCAAACTGTCAAAGCTGGCAGAGACGCTCTAT
GACACCACCAAGGTCAGTTTCACCTATGACGAGACGGCAGGCATGCTGAAGACCATCAACCTACAGAATGAGGGCTTCACCTGCACCATC
CGCTACCGTCAGATTGGGCCCCTGATTGACCGACAGATCTTCCGCTTCACTGAGGAAGGCATGGTCAACGCCCGTTTTGACTACAACTAT
GACAACAGCTTCCGGGTGACCAGCATGCAGGCTGTGATCAACGAGACCCCACTGCCCATTGATCTCTATCGCTATGATGATGTGTCAGGC
AAGACAGAGCAGTTTGGGAAGTTTGGTGTCATTTACTATGACATTAACCAGATCATCACCACAGCTGTCATGACCCACACCAAGCATTTT
GATGCATATGGCAGGATGAAGGAAGTGCAGTATGAGATCTTCCGCTCGCTCATGTACTGGATGACCGTCCAGTATGATAACATGGGGCGA
GTAGTGAAGAAGGAGCTGAAGGTAGGACCCTACGCCAATACCACTCGCTACTCCTATGAGTATGATGCTGACGGCCAGCTGCAGACAGTC
TCCATCAATGACAAGCCACTCTGGCGCTACAGCTACGACCTCAATGGGAACCTGCACTTACTGAGCCCTGGGAACAGTGCACGGCTCACA
CCACTACGGTATGACATCCGCGACCGCATCACTCGGCTGGGTGACGTGCAATACAAGATGGATGAGGATGGCTTCCTGAGGCAGCGGGGC
GGTGATATCTTTGAGTACAACTCAGCTGGCCTGCTCATCAAGGCCTACAACCGGGCTGGCAGCTGGAGTGTCAGGTACCGCTACGATGGC
CTGGGGCGGCGCGTGTCCAGCAAGAGCAGCCACAGCCACCACCTGCAGTTCTTCTATGCAGACCTGACCAACCCCACCAAGGTCACCCAC
CTGTACAACCACTCCAGCTCTGAGATCACCTCCCTCTACTACGACTTGCAAGGACACCTCTTTGCCATGGAGCTGAGCAGTGGTGATGAG
TTTTACATAGCTTGTGACAACATCGGGACCCCTCTTGCTGTCTTTAGTGGAACAGGTTTGATGATCAAGCAAATCCTGTACACAGCCTAT
GGGGAGATCTACATGGATACCAACCCCAACTTTCAGATCATCATAGGCTACCATGGTGGCCTCTATGATCCACTCACCAAGCTTGTCCAC
ATGGGCCGGCGAGATTATGATGTGCTGGCCGGACGCTGGACTAGCCCAGACCACGAGCTGTGGAAGCACCTTAGTAGCAGCAACGTCATG
CCTTTTAATCTCTATATGTTCAAAAACAACAACCCCATCAGCAACTCCCAGGACATCAAGTGCTTCATGACAGATGTTAACAGCTGGCTG
CTCACCTTTGGATTCCAGCTACACAACGTGATCCCTGGTTATCCCAAACCAGACATGGATGCCATGGAACCCTCCTACGAGCTCATCCAC
ACACAGATGAAAACGCAGGAGTGGGACAACAGCAAGTCTATCCTCGGGGTACAGTGTGAAGTACAGAAGCAGCTCAAGGCCTTTGTCACC
TTAGAACGGTTTGACCAGCTCTATGGCTCCACAATCACCAGCTGCCAGCAGGCTCCAAAGACCAAGAAGTTTGCATCCAGCGGCTCAGTC
TTTGGCAAGGGGGTCAAGTTTGCCTTGAAGGATGGCCGAGTGACCACAGACATCATCAGTGTGGCCAATGAGGATGGGCGAAGGGTTGCT
GCCATCTTGAACCATGCCCACTACCTAGAGAACCTGCACTTCACCATTGATGGGGTGGATACCCATTACTTTGTGAAACCAGGACCTTCA
GAAGGTGACCTGGCCATCCTGGGCCTCAGTGGGGGGCGGCGAACCCTGGAGAATGGGGTCAACGTCACTGTGTCCCAGATCAACACAGTA
CTTAATGGCAGGACTAGACGCTACACAGACATCCAGCTCCAGTACGGGGCACTGTGCTTGAACACACGCTACGGGACAACGTTGGATGAG
GAGAAGGCACGGGTCCTGGAGCTGGCCCGGCAGAGAGCCGTGCGCCAAGCGTGGGCCCGCGAGCAGCAGAGACTGCGGGAAGGGGAGGAA
GGCCTGCGGGCCTGGACAGAGGGGGAGAAGCAGCAGGTGCTGAGCACAGGGCGGGTGCAAGGCTACGACGGCTTTTTCGTGATCTCTGTC
GAGCAGTACCCAGAACTGTCAGACAGCGCCAACAACATCCACTTCATGAGACAGAGCGAGATGGGCCGGAGGTGACAGAGAGGACCAAGG
ACTTCTTGCCAAAGACAGCTACTCTTTTGTGGCCGCATACCTGACTGTGTTGTACTTTTAAAAAAATGATTTTTTAACAAGTGCAGAAAC
AAAAAGATACTGGTTGCATTGTAACTCATGCAACATCCTTTTTTTTAGAAAAGAAAAACACAGATTTGGCCTTCGCACATTTTTTGCAAA
GAACAGAAGGTATTTTTTTCTGTAGTGTGATCACAATGAAAACTTTATTGTCTTTTGTTCCCTTTTTCCTTGAGGATTTTTCCCTTGTCG
TTTGGGGTATGTATCTCCTCTCTGAGATGCATCTCCTGGGGTGTGTCCTCGTCTGTCCCTAGGTACCCAGTGTGATGTGGGACATGAATG
TCTGTGCTAACTTGTCTCATGTGCAACCCTTTCTTCTTCGACTGGGGTCGGGCAGGAGTAAAGGGAGTGATGGGCCAGTACAACACCCCT
TCCAAGGGGGCCTGGGAGGAGGGTCTGTAGGACCTGAGGCTCCTTGGCAGGGCTCCTGCAGAAGAGTGGTGGATTTCTTCTCACCTTGTT
CTCTGCCTCCAGAGGATCATAGATGGCTTCATCTTGCTCCAGGGAATTTCATGGTGTTGTTCAGCACCTTTTTTAAGCTGCCCCAAACTC
CTGTTCAAGCTTTCTATTTTGATGCTGAATGAAACCCCCTACCACTTTTGCAAATCCTGTGTAGTTGTCGGTGCCACCCCCATGCTGGGA
TAGAGAAAGTGTCTCCCAGGTCCTTTCCCCCAGACCAGTGACATAACATCCTGGGCTCAGAGTCCCATCCTCCCGGGAGGGAAAGCACCC
AGGATGCCTGTGATTGGTTGGTCCTCCATGATGTTCCTGTTCATCTCCTCCTTTCTCCCAAAGCCAGATGTGAGAACGAGCACTGCACAG
CAAGCCTTCAATGTGGGCACCATGTCCACAGAACAGAAGGCCACCCATGGCAAAGGCATGGCAGTGGTGGCGAGGGCACCAGCCTGCCTT
CCGAGGCAAAGCCCTCTCTCTATGACTTTGAGTATCTTCCCTCCACCACTCAGCCGCCACCACTGAGACGTAGGAATGTGGAGGGAGGTG
CTTGGTGGCCTTTGATTCTGGAAAAATGCTTAACAAAAAAAGCCAGCCAAAGAGAGGAAGGCATAAGCTAAGCATCCTTCTAACCAGTTC
CCAAAGTCCCATCTGCCTCCATGTACCAGCTGATCGCAGAGCTGGACTGGGGCAGGCTGGGCTTCCAGGAAATTCCTGAAGTTCTGAAAC
AGCTTCCCCTCTAGAGAAGCCCACCCAATGTGTTTTTTAGTGACAGGAAGAAAGGAGGGAAGAGCTGATGTGGTGTGGCCTGCCCATATC
ATACAACCCCACCAGGAGCAGGGCAGTTCCCAAGGTGGGTGCCCGTAGATCTGGGAGGCCAGGCTGGCATGATTCCTGTGAAGAACTGTG
CCTGTGTCGTCAGGGAGAGGCCTGAGCCCTCTCAGAAGCAGGGACAGCCCACACCTGAAGAGCACGCCCAAGCTGAGGCAGCAGCCAGCA
GGCTGGGGGAGCAGTGAGGGCAGGGGGAGTCACAGCCAGAGCTGGGAGCCCCTTGTTCAAGGATTCCATTCCTGGTTCATCCGCCTAATT
ACCATTGTCATTACCACTCACAGGAGGCTCTGGGAGATGGGAGGGGAAGCCAAATGCTTCCTTTTAAGCTGGGCTTCTTAGAAAATGGAA
CTTTTATGGGTTACATTTACATTAAGTGTGGAAAATGAATTCTGAGTCTGAGCTATTCCCCGTGGAAACCTTGTTGGACTGATAAGCTCA
TGGCACCTCTATAGCCTTACTCACATAGTCTTCAGAATATTACACAAGTTAATGAAACTGAGAAGGTCTGACTGCATGAGGATCGGAGCA
GCATGTAGTCTGGGTTCTGCCTGGCAGAGGGAGGCAACCAAAACTTCTTGGGGAGAGGAGATTTCGCCTTAACGTCATCCCACTGGGATT
AGAGGATGTGTTTCGCTAAGTGCTCTTCCTGTTTCCAAAAAAAAAGCCACCCTGCTGCAGCAGTGCGCTTTGGCCTGCTTGTCCACTGGT
TGCCCATTGCCCCTGGATCCAGAGCTCTACTGAGTCAGATACAGTGCTCTGCAGGCCTGCTGTGGGAGGCATGAGCTGGAGATGGGGGCT
CCCATCTGGCAGGATCATTCTTGGATGAGATGGAAAACAGTTTGGCCTGAAGAACACAAGTTTTGTCCTCCAGAAGGGACTTACGCCTCT
CAAAATGTACTCTTCATACCAAGGGCCCTTGGGCAAAGTGCTCCTGCCCAGTTGATCAGTCCCATCCTGGCTGCCTGACATCAGTGAAGA
CCTGCTGGGGATGTCTGCTCAGAGGTCAGGAACGGCATGCGGTCCACAGGAACCAGCTCCCTACGCTTCCCCCACGCCCTGTCCCTCCTC
CACAGCCCCCTCCCCAAAGGAATAGGGTGGACTTTTAGGGATCAAAAACAGAATTATTGGGTGTTTCATTTATTTTTTTCTTTCTTTCTT
TTTTTTTTCATAGAGATGGGGTCTCACTATGTTGCCCAGGCTGTTCTCAAACTCCTGGCCTCAGGCGATCCACCTTGGCCTCCTGAAGTG
CTGGGGTTACAGGTGTGAGCCACTGCGCCTGGACTGAGTGTTTGTTTCTTTAAAGGATCTTATATTTTTCCTGTGCTACATACCACCACA
GCAGCCCAGCTTCTGTGGGGAGAGAAGTTGAAGGATCCCGAAGCTTTAGAAAAAGGATCTCAGCTGTGGCACAGGCAGTGTTATGCGCCT
CACTGCCACATTGGTGCTGTTGTATTGAAGGTGGTGCTTCTGGCCTTGGCCCTTTTGAGTTGGTTTCCATTTGGGCTGCAGGTGACTCAG
TGACTCCCTCCTCAAGCTGTCCTCCTGCTAAGACCAGCAGTCACAAACCCATGGCAAGGGTGAGTGTGAAGGCCTAACCCTGTGCCTATG
TAATAGGCTCCAAGCATCGACTCCCATCCTGAGAGGACCGGCCCTTTTGACACTCACCAACCAAATCTGTTCATTCGATAGAGTGACCAG
GCCTCCCTCACCTGCCCAGGTGTATGATCCTACAGTTCCTGCCTTCTCTCCTACCCCGCACAGCTGCCAACTGGTCCTACATCCTCAGCC
CCTCTGCCACCACCTTAAATAGGACTTTACTGATTCCCCAACTTTGTTTTTTTGTAGGATGAGATTTCCTTTTTATCCCACCCCCCCACA
CCCCAAACAGACATTGCTGGAGGGCAGACTGGAGGAAGGGGAAGGCATGCAGGTAAATTACTGCCTTGTCAGCCTCTGACCCTCATCTCT
CAGAATTGTTGGCTGAGAATTAACCCAAGGACCACACCAGTGCCTGATTTCTACTTAGGGAGAGAGGATTGGAAACGATCCCTAAGAAAC
TGACTGAGGGTGAGAATGGCCAGGAGGTGTGTGTCCAAATAACCAGGAGGGGGCACAGAAGATGATGGCAAGGCAGACTGGGCAGTGTTT
TGTAGACACAGAACAAAGAATCAGAATTTGAAAAAAGAAGAAAAACAAATCTTCGCAGCTGCAACTTTAAAGTATCACCTTTATAGATGG
CAGGGATTTCCATTATGCAAATGGAATCTAAGATTTCAATGTGAAATCTTAGAATGCAGTTTTACCACTTGCAGTCTTGTATTTGTGGTG
GCCATGTGGTGAGGGCGGTGATGCTGAGCTTTCTGCCCAGGAGGAATGAGCTTTCAAGCTCTCAGCAGGGTGTCAGGCTTGGGGATTTGA
GCATCCACTGCTCAAAGTCCAGGCTATTCTCCAGTCCTCACGGCAGCCACTAAGCCCAGGAGCCAGACCTGGCCCGGGGACACATCTCCT
GAGGGATCCCAGAAAGAACCCAGTCTTTCCTTTCCCTTGGGGTCCTTGTTAGAATGAAAACCTCTCTATTTAAGGCACATCATTCCCAGC
TAGGTTTATACACTTGTCTATATTTTACTGGAGGAAAGGGAATTAAAAAAGAACTCTGCAGTTCAAGGCCCTTTCATTTAACCTTCCAAA
AACAGCAAACTCATTTTAAAGACTCATTGCTGAGGTGATAGAGAGAAACCTTATCCTCTCCAACCTTCACATTCACAAAAACCATCCTTG
TGTACTTGACTGCCCTAGACAGTGGTGACTCTTAGGTTTCATTACGAATGTGGAATATCAGAGTGTGGGAAGGCCCAGGCGAGGGCCAAT
GTTGTGTTTCTTACCCCCTCTGGAATGCCAAAGGCAAGGTACTAGGTGACCTCCTGGTCCCCAAGAAAATGTGATTTATTCTGAGGGCGA
ACAGCCAAGGGAGGACTAGTCTGGAGCACGCTCGGCCGTCCTGGCAGGAGCTGAGCCTCAGGTGTCTGGCGGTGCCCCAGCAGCCCTGGA
TTCACCCAACACCAGAATCCCACTTTTCTAAATCCACCTGTTGTTCTGAGCACCTCTGAACCCGCAGCTTCGGCAAAAGGAGTCTGTACC
AAGCTGCTTCTGGATGACCAACACTGGAGACTCTGGCCTTACCATGTGGAAATCATTTTCCTGAAGTCTGGAACTAATTTTGAGAAGTTT
TTTTCTCAACACTTTTGTGTTTCTAACACTGTATCTTGACTGTGTAAATACCAACAAGGCTGTAAATAAATGCAGATGTAGATACCTTCT
AGAAAAAAAAAAGCATAAAAACAAAACCAGAAGTGATCCCGTGTAGCCTTCGTTGACAAATAAAGACTATTTTGTGTTTACAGGTGTCTG
GTGGCCTTTGCTTGGAGATAAAGGCTTCCTCTTGCCTGTCCCAGCCCCCGAGCCATCCTGGGTTTGCACTTCCCTGCTGGCTGCTATCAG
GATGACCTGGGAGAGGACTCAGTCCTAGGCCCCAGGGTCCCTCTAAATCCCTCCAGGCTGCAGCTCTGTCAAGAGGGATGTCCAGAGGGT
CTCTAAGACCCTGAAGCTTGACTTTGCAATTGCATGACAGGAATAAATATCACAGCTCCTCTGACATCACTAGTGCAGCGTGGCTCCCCA
TCCCACTGCTGCCCTCGTTCAGGGACAGGCTGAAGGGGCCAACGAACCCAACCCTCCCAGAGGAGGGAGCCTTGCTCCACCACTGGGCAC

>78414_78414_2_RSF1-TENM4_RSF1_chr11_77436590_ENST00000360355_TENM4_chr11_78567223_ENST00000278550_length(amino acids)=2564AA_BP=205
MATAAAAAAVMAPPGCPGSCPNFAVVCSFLERYGPLLDLPELPFPELERVLQAPPPDVGNGEVPKELVELHLKLMRKIGKSVTADRWEKY
LIKYLCECQFDDNLKFKNIINEEDADTMRLQPIGRDKDGLMYWYQLDQDHNVRMYIEEQDDQDGSSWKCIVRNRNELAETLALLKAQIDP
VLLKNSSQQDNSSRESPSLEDEETKKEEETPKQGKPSSFFPEDSFIDSGEIDVGRRASQKIPPGTFWRSQVFIDHPVHLKFNVSLGKAAL
VGIYGRKGLPPSHTQFDFVELLDGRRLLTQEARSLEGTPRQSRGTVPPSSHETGFIQYLDSGIWHLAFYNDGKESEVVSFLTTAIESVDN
CPSNCYGNGDCISGTCHCFLGFLGPDCGRASCPVLCSGNGQYMKGRCLCHSGWKGAECDVPTNQCIDVACSNHGTCITGTCICNPGYKGE
SCEEVDCMDPTCSGRGVCVRGECHCSVGWGGTNCETPRATCLDQCSGHGTFLPDTGLCSCDPSWTGHDCSIEICAADCGGHGVCVGGTCR
CEDGWMGAACDQRACHPRCAEHGTCRDGKCECSPGWNGEHCTIAHYLDRVVKEGCPGLCNGNGRCTLDLNGWHCVCQLGWRGAGCDTSME
TACGDSKDNDGDGLVDCMDPDCCLQPLCHINPLCLGSPNPLDIIQETQVPVSQQNLHSFYDRIKFLVGRDSTHIIPGENPFDGGHACVIR
GQVMTSDGTPLVGVNISFVNNPLFGYTISRQDGSFDLVTNGGISIILRFERAPFITQEHTLWLPWDRFFVMETIIMRHEENEIPSCDLSN
FARPNPVVSPSPLTSFASSCAEKGPIVPEIQALQEEISISGCKMRLSYLSSRTPGYKSVLRISLTHPTIPFNLMKVHLMVAVEGRLFRKW
FAAAPDLSYYFIWDKTDVYNQKVFGLSEAFVSVGYEYESCPDLILWEKRTTVLQGYEIDASKLGGWSLDKHHALNIQSGILHKGNGENQF
VSQQPPVIGSIMGNGRRRSISCPSCNGLADGNKLLAPVALTCGSDGSLYVGDFNYIRRIFPSGNVTNILELRNKDFRHSHSPAHKYYLAT
DPMSGAVFLSDSNSRRVFKIKSTVVVKDLVKNSEVVAGTGDQCLPFDDTRCGDGGKATEATLTNPRGITVDKFGLIYFVDGTMIRRIDQN
GIISTLLGSNDLTSARPLSCDSVMDISQVHLEWPTDLAINPMDNSLYVLDNNVVLQISENHQVRIVAGRPMHCQVPGIDHFLLSKVAIHA
TLESATALAVSHNGVLYIAETDEKKINRIRQVTTSGEISLVAGAPSGCDCKNDANCDCFSGDDGYAKDAKLNTPSSLAVCADGELYVADL
GNIRIRFIRKNKPFLNTQNMYELSSPIDQELYLFDTTGKHLYTQSLPTGDYLYNFTYTGDGDITLITDNNGNMVNVRRDSTGMPLWLVVP
DGQVYWVTMGTNSALKSVTTQGHELAMMTYHGNSGLLATKSNENGWTTFYEYDSFGRLTNVTFPTGQVSSFRSDTDSSVHVQVETSSKDD
VTITTNLSASGAFYTLLQDQVRNSYYIGADGSLRLLLANGMEVALQTEPHLLAGTVNPTVGKRNVTLPIDNGLNLVEWRQRKEQARGQVT
VFGRRLRVHNRNLLSLDFDRVTRTEKIYDDHRKFTLRILYDQAGRPSLWSPSSRLNGVNVTYSPGGYIAGIQRGIMSERMEYDQAGRITS
RIFADGKTWSYTYLEKSMVLLLHSQRQYIFEFDKNDRLSSVTMPNVARQTLETIRSVGYYRNIYQPPEGNASVIQDFTEDGHLLHTFYLG
TGRRVIYKYGKLSKLAETLYDTTKVSFTYDETAGMLKTINLQNEGFTCTIRYRQIGPLIDRQIFRFTEEGMVNARFDYNYDNSFRVTSMQ
AVINETPLPIDLYRYDDVSGKTEQFGKFGVIYYDINQIITTAVMTHTKHFDAYGRMKEVQYEIFRSLMYWMTVQYDNMGRVVKKELKVGP
YANTTRYSYEYDADGQLQTVSINDKPLWRYSYDLNGNLHLLSPGNSARLTPLRYDIRDRITRLGDVQYKMDEDGFLRQRGGDIFEYNSAG
LLIKAYNRAGSWSVRYRYDGLGRRVSSKSSHSHHLQFFYADLTNPTKVTHLYNHSSSEITSLYYDLQGHLFAMELSSGDEFYIACDNIGT
PLAVFSGTGLMIKQILYTAYGEIYMDTNPNFQIIIGYHGGLYDPLTKLVHMGRRDYDVLAGRWTSPDHELWKHLSSSNVMPFNLYMFKNN
NPISNSQDIKCFMTDVNSWLLTFGFQLHNVIPGYPKPDMDAMEPSYELIHTQMKTQEWDNSKSILGVQCEVQKQLKAFVTLERFDQLYGS
TITSCQQAPKTKKFASSGSVFGKGVKFALKDGRVTTDIISVANEDGRRVAAILNHAHYLENLHFTIDGVDTHYFVKPGPSEGDLAILGLS
GGRRTLENGVNVTVSQINTVLNGRTRRYTDIQLQYGALCLNTRYGTTLDEEKARVLELARQRAVRQAWAREQQRLREGEEGLRAWTEGEK

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Fusion Gene PPI Analysis for RSF1-TENM4


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for RSF1-TENM4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for RSF1-TENM4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource