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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:RTCB-DEPDC5 (FusionGDB2 ID:78503)

Fusion Gene Summary for RTCB-DEPDC5

check button Fusion gene summary
Fusion gene informationFusion gene name: RTCB-DEPDC5
Fusion gene ID: 78503
HgeneTgene
Gene symbol

RTCB

DEPDC5

Gene ID

51493

9681

Gene nameRNA 2',3'-cyclic phosphate and 5'-OH ligaseDEP domain containing 5, GATOR1 subcomplex subunit
SynonymsC22orf28|DJ149A16.6|FAAP|HSPC117DEP.5|FFEVF|FFEVF1
Cytomap

22q12.3

22q12.2-q12.3

Type of geneprotein-codingprotein-coding
DescriptiontRNA-splicing ligase RtcB homologankyrin repeat domain 54focal adhesion-associated proteinGATOR complex protein DEPDC5DEP domain containing 5DEP domain-containing protein 5
Modification date2020031320200315
UniProtAcc

Q9Y3I0

O75140

Ensembl transtripts involved in fusion geneENST00000216038, ENST00000451746, 
ENST00000476619, 		ENST00000400242, 
ENST00000494060, ENST00000536766, 
ENST00000539165, ENST00000266091, 
ENST00000382105, ENST00000382111, 
ENST00000382112, ENST00000400246, 
ENST00000400248, ENST00000400249, 
ENST00000535622, 
Fusion gene scores* DoF score3 X 3 X 3=2715 X 17 X 7=1785
# samples 417
** MAII scorelog2(4/27*10)=0.567040592723894
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(17/1785*10)=-3.39231742277876
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: RTCB [Title/Abstract] AND DEPDC5 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointRTCB(32802649)-DEPDC5(32275511), # samples:1
Anticipated loss of major functional domain due to fusion event.RTCB-DEPDC5 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
RTCB-DEPDC5 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneRTCB

GO:0006388

tRNA splicing, via endonucleolytic cleavage and ligation

21311021|24870230


check buttonFusion gene breakpoints across RTCB (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across DEPDC5 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-BR-8296-01ARTCBchr22

32802649

-DEPDC5chr22

32275511

+


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Fusion Gene ORF analysis for RTCB-DEPDC5

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000216038ENST00000400242RTCBchr22

32802649

-DEPDC5chr22

32275511

+
5CDS-intronENST00000216038ENST00000494060RTCBchr22

32802649

-DEPDC5chr22

32275511

+
5CDS-intronENST00000216038ENST00000536766RTCBchr22

32802649

-DEPDC5chr22

32275511

+
5CDS-intronENST00000216038ENST00000539165RTCBchr22

32802649

-DEPDC5chr22

32275511

+
5CDS-intronENST00000451746ENST00000400242RTCBchr22

32802649

-DEPDC5chr22

32275511

+
5CDS-intronENST00000451746ENST00000494060RTCBchr22

32802649

-DEPDC5chr22

32275511

+
5CDS-intronENST00000451746ENST00000536766RTCBchr22

32802649

-DEPDC5chr22

32275511

+
5CDS-intronENST00000451746ENST00000539165RTCBchr22

32802649

-DEPDC5chr22

32275511

+
5UTR-3CDSENST00000476619ENST00000266091RTCBchr22

32802649

-DEPDC5chr22

32275511

+
5UTR-3CDSENST00000476619ENST00000382105RTCBchr22

32802649

-DEPDC5chr22

32275511

+
5UTR-3CDSENST00000476619ENST00000382111RTCBchr22

32802649

-DEPDC5chr22

32275511

+
5UTR-3CDSENST00000476619ENST00000382112RTCBchr22

32802649

-DEPDC5chr22

32275511

+
5UTR-3CDSENST00000476619ENST00000400246RTCBchr22

32802649

-DEPDC5chr22

32275511

+
5UTR-3CDSENST00000476619ENST00000400248RTCBchr22

32802649

-DEPDC5chr22

32275511

+
5UTR-3CDSENST00000476619ENST00000400249RTCBchr22

32802649

-DEPDC5chr22

32275511

+
5UTR-3CDSENST00000476619ENST00000535622RTCBchr22

32802649

-DEPDC5chr22

32275511

+
5UTR-intronENST00000476619ENST00000400242RTCBchr22

32802649

-DEPDC5chr22

32275511

+
5UTR-intronENST00000476619ENST00000494060RTCBchr22

32802649

-DEPDC5chr22

32275511

+
5UTR-intronENST00000476619ENST00000536766RTCBchr22

32802649

-DEPDC5chr22

32275511

+
5UTR-intronENST00000476619ENST00000539165RTCBchr22

32802649

-DEPDC5chr22

32275511

+
Frame-shiftENST00000216038ENST00000382105RTCBchr22

32802649

-DEPDC5chr22

32275511

+
Frame-shiftENST00000451746ENST00000266091RTCBchr22

32802649

-DEPDC5chr22

32275511

+
Frame-shiftENST00000451746ENST00000382111RTCBchr22

32802649

-DEPDC5chr22

32275511

+
Frame-shiftENST00000451746ENST00000382112RTCBchr22

32802649

-DEPDC5chr22

32275511

+
Frame-shiftENST00000451746ENST00000400246RTCBchr22

32802649

-DEPDC5chr22

32275511

+
Frame-shiftENST00000451746ENST00000400248RTCBchr22

32802649

-DEPDC5chr22

32275511

+
Frame-shiftENST00000451746ENST00000400249RTCBchr22

32802649

-DEPDC5chr22

32275511

+
Frame-shiftENST00000451746ENST00000535622RTCBchr22

32802649

-DEPDC5chr22

32275511

+
In-frameENST00000216038ENST00000266091RTCBchr22

32802649

-DEPDC5chr22

32275511

+
In-frameENST00000216038ENST00000382111RTCBchr22

32802649

-DEPDC5chr22

32275511

+
In-frameENST00000216038ENST00000382112RTCBchr22

32802649

-DEPDC5chr22

32275511

+
In-frameENST00000216038ENST00000400246RTCBchr22

32802649

-DEPDC5chr22

32275511

+
In-frameENST00000216038ENST00000400248RTCBchr22

32802649

-DEPDC5chr22

32275511

+
In-frameENST00000216038ENST00000400249RTCBchr22

32802649

-DEPDC5chr22

32275511

+
In-frameENST00000216038ENST00000535622RTCBchr22

32802649

-DEPDC5chr22

32275511

+
In-frameENST00000451746ENST00000382105RTCBchr22

32802649

-DEPDC5chr22

32275511

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000216038RTCBchr2232802649-ENST00000535622DEPDC5chr2232275511+1699439121445477
ENST00000216038RTCBchr2232802649-ENST00000400246DEPDC5chr2232275511+1902439121292426
ENST00000216038RTCBchr2232802649-ENST00000266091DEPDC5chr2232275511+1963439121445477
ENST00000216038RTCBchr2232802649-ENST00000400249DEPDC5chr2232275511+1963439121445477
ENST00000216038RTCBchr2232802649-ENST00000382112DEPDC5chr2232275511+1954439121445477
ENST00000216038RTCBchr2232802649-ENST00000382111DEPDC5chr2232275511+1786439121292426
ENST00000216038RTCBchr2232802649-ENST00000400248DEPDC5chr2232275511+1975439121445477
ENST00000451746RTCBchr2232802649-ENST00000382105DEPDC5chr2232275511+194542191427472

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000216038ENST00000535622RTCBchr2232802649-DEPDC5chr2232275511+0.0095748440.99042517
ENST00000216038ENST00000400246RTCBchr2232802649-DEPDC5chr2232275511+0.054915830.9450842
ENST00000216038ENST00000266091RTCBchr2232802649-DEPDC5chr2232275511+0.0095182580.9904818
ENST00000216038ENST00000400249RTCBchr2232802649-DEPDC5chr2232275511+0.0095182580.9904818
ENST00000216038ENST00000382112RTCBchr2232802649-DEPDC5chr2232275511+0.0096309090.990369
ENST00000216038ENST00000382111RTCBchr2232802649-DEPDC5chr2232275511+0.044844350.9551557
ENST00000216038ENST00000400248RTCBchr2232802649-DEPDC5chr2232275511+0.0095280090.99047196
ENST00000451746ENST00000382105RTCBchr2232802649-DEPDC5chr2232275511+0.0092124640.99078757

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Fusion Genomic Features for RTCB-DEPDC5


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
RTCBchr2232802648-DEPDC5chr2232275510+3.30E-060.99999666
RTCBchr2232802648-DEPDC5chr2232275510+3.30E-060.99999666

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for RTCB-DEPDC5


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr22:32802649/chr22:32275511)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
RTCB

Q9Y3I0

DEPDC5

O75140

FUNCTION: Catalytic subunit of the tRNA-splicing ligase complex that acts by directly joining spliced tRNA halves to mature-sized tRNAs by incorporating the precursor-derived splice junction phosphate into the mature tRNA as a canonical 3',5'-phosphodiester. May act as an RNA ligase with broad substrate specificity, and may function toward other RNAs. {ECO:0000255|HAMAP-Rule:MF_03144, ECO:0000269|PubMed:21311021, ECO:0000269|PubMed:24870230}.FUNCTION: As a component of the GATOR1 complex functions as an inhibitor of the amino acid-sensing branch of the TORC1 pathway. The GATOR1 complex strongly increases GTP hydrolysis by RRAGA and RRAGB within RRAGC-containing heterodimers, thereby deactivating RRAGs, releasing mTORC1 from lysosomal surface and inhibiting mTORC1 signaling. The GATOR1 complex is negatively regulated by GATOR2 the other GATOR subcomplex in this amino acid-sensing branch of the TORC1 pathway. {ECO:0000269|PubMed:23723238, ECO:0000269|PubMed:25457612, ECO:0000269|PubMed:29769719}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneDEPDC5chr22:32802649chr22:32275511ENST000004002420221187_12620560.0DomainDEP
TgeneDEPDC5chr22:32802649chr22:32275511ENST0000053562233401187_126211681504.0DomainDEP

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneRTCBchr22:32802649chr22:32275511ENST00000216038-412226_230113506.0Nucleotide bindingGMP
HgeneRTCBchr22:32802649chr22:32275511ENST00000216038-412353_354113506.0Nucleotide bindingGMP
HgeneRTCBchr22:32802649chr22:32275511ENST00000216038-412402_405113506.0Nucleotide bindingGMP
HgeneRTCBchr22:32802649chr22:32275511ENST00000216038-412428_431113506.0Nucleotide bindingGMP
TgeneDEPDC5chr22:32802649chr22:32275511ENST0000026609135421187_126212461582.0DomainDEP
TgeneDEPDC5chr22:32802649chr22:32275511ENST0000038211135411187_126212681553.0DomainDEP
TgeneDEPDC5chr22:32802649chr22:32275511ENST0000038211235421187_126212591595.0DomainDEP
TgeneDEPDC5chr22:32802649chr22:32275511ENST0000040024636421187_126212681553.0DomainDEP
TgeneDEPDC5chr22:32802649chr22:32275511ENST0000040024834411187_126212371573.0DomainDEP
TgeneDEPDC5chr22:32802649chr22:32275511ENST0000040024935421187_126212371573.0DomainDEP


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Fusion Gene Sequence for RTCB-DEPDC5


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>78503_78503_1_RTCB-DEPDC5_RTCB_chr22_32802649_ENST00000216038_DEPDC5_chr22_32275511_ENST00000266091_length(transcript)=1963nt_BP=439nt
GCGCTTTGGTTCTTGGAAGGCGGTGCTCTGAGAAGCCGGACTACGCGGCAGCGGCTCTTCAAAGCGGAGCCGGGAGTTTTTGCTACAGTT
TTCGCCACCATGAGTCGCAGCTATAATGATGAGCTGCAGTTCTTGGAGAAGATCAATAAAAACTGCTGGAGGATCAAGAAGGGCTTCGTG
CCCAACATGCAGGTTGAAGGTGTTTTCTATGTGAATGATGCTCTGGAGAAATTGATGTTTGAGGAATTAAGGAATGCCTGTCGAGGTGGT
GGTGTTGGTGGCTTCCTGCCAGCCATGAAACAGATTGGCAATGTGGCAGCCCTGCCTGGAATTGTTCATCGATCTATTGGGCTTCCTGAT
GTCCATTCAGGATATGGGTTTGCTATTGGGAACATGGCAGCCTTTGATATGAATGACCCTGAAGCAGTAGTATCCCCAGTGGCCATGCAG
CAGCCCGCCACCACCTGGCACACAGCAGGAGTGGACGACTTCGCCAGCTTCCAGCGCAAGTGGTTTGAGGTGGCCTTTGTGGCAGAAGAG
CTCGTGCACTCTGAGATTCCTGCCTTTCTCCTGCCCTGGCTGCCTAGCCGGCCAGCCTCCTATGCAAGTAGGCACAGCTCCTTTAGCCGA
AGTTTTGGAGGACGGAGCCAGGCGGCAGCACTTTTAGCTGCCACTGTCCCAGAGCAGAGGACTGTGACCCTGGATGTTGACGTGAACAAC
CGCACAGACCGGCTGGAGTGGTGCAGCTGTTATTACCATGGCAACTTTTCTCTGAATGCAGCCTTTGAGATCAAGCTGCACTGGATGGCG
GTGACCGCAGCAGTACTCTTCGAGATGGTCCAAGGTTGGCATCGGAAAGCCACCTCCTGTGGCTTCTTGTTAGTCCCAGTTTTGGAGGGG
CCTTTTGCACTGCCCAGTTACCTGTATGGCGACCCCCTTCGTGCCCAGCTCTTCATCCCACTCAACATCAGCTGCTTGCTCAAGGAGGGC
AGCGAGCACCTGTTTGATAGCTTTGAACCCGAAACGTACTGGGATCGAATGCACCTCTTCCAGGAAGCCATTGCACACAGGTTTGGGTTT
GTACAAGATAAATATTCTGCCTCTGCTTTTAACTTCCCTGCTGAGAACAAGCCTCAGTATATCCACGTTACAGGAACAGTGTTTCTGCAG
CTGCCCTACTCCAAGCGCAAGTTCTCAGGGCAGCAGCGGCGGCGGCGGAACTCCACCAGCTCCACCAACCAGAACATGTTCTGCGAGGAG
CGGGTCGGCTACAACTGGGCCTACAACACCATGCTCACCAAAACATGGCGCTCCAGCGCCACAGGGGATGAAAAGTTTGCTGATCGGCTG
CTGAAGGACTTCACGGACTTCTGCATCAACCGTGACAACCGGCTGGTCACGTTCTGGACAAGTTGCCTGGAGAAGATGCATGCCAGTGCC
CCGTGAGGCCAGGCTGCACCTGTGCTGGGGGAAGGTGGGTGAGCCACTGCCCTCAAACCCGGGGCGGAGGATTCCAGGCAGGCTCTAGGA
GTCAGGTGTCCGTTTGCTGCTATCAGTGAGTGGGGGCCATTGTTTTTTGTTTGTTTGTTTGTTTGTTTGTTTGTTTTTGGCCCCCACGAC
AAGTCTTCTACTCTAGAAGAAAGACTTTGGAAGCAGCTGCTGCTGCTGCCACCACTCCTGTCAGCAAGTGCTCAGAGCAGGTGGGAGGCA
CAGATTGTCCGTGGGAGGGCTCCAGTGTCTGGGAAGAGGGCAGGCGGCCCCCATGAATGTCCTCGGAAGGGGGTGGCTCCTGGTAGCATC
CTTTTCCTTCACCATCTATGGGATATTAGGGGCAGAATCTGCCACTTCTTGCCCAGGAGTGTGCACAGATGTAAGATAATTTTGTGAAAT

>78503_78503_1_RTCB-DEPDC5_RTCB_chr22_32802649_ENST00000216038_DEPDC5_chr22_32275511_ENST00000266091_length(amino acids)=477AA_BP=141
MEGGALRSRTTRQRLFKAEPGVFATVFATMSRSYNDELQFLEKINKNCWRIKKGFVPNMQVEGVFYVNDALEKLMFEELRNACRGGGVGG
FLPAMKQIGNVAALPGIVHRSIGLPDVHSGYGFAIGNMAAFDMNDPEAVVSPVAMQQPATTWHTAGVDDFASFQRKWFEVAFVAEELVHS
EIPAFLLPWLPSRPASYASRHSSFSRSFGGRSQAAALLAATVPEQRTVTLDVDVNNRTDRLEWCSCYYHGNFSLNAAFEIKLHWMAVTAA
VLFEMVQGWHRKATSCGFLLVPVLEGPFALPSYLYGDPLRAQLFIPLNISCLLKEGSEHLFDSFEPETYWDRMHLFQEAIAHRFGFVQDK
YSASAFNFPAENKPQYIHVTGTVFLQLPYSKRKFSGQQRRRRNSTSSTNQNMFCEERVGYNWAYNTMLTKTWRSSATGDEKFADRLLKDF

--------------------------------------------------------------
>78503_78503_2_RTCB-DEPDC5_RTCB_chr22_32802649_ENST00000216038_DEPDC5_chr22_32275511_ENST00000382111_length(transcript)=1786nt_BP=439nt
GCGCTTTGGTTCTTGGAAGGCGGTGCTCTGAGAAGCCGGACTACGCGGCAGCGGCTCTTCAAAGCGGAGCCGGGAGTTTTTGCTACAGTT
TTCGCCACCATGAGTCGCAGCTATAATGATGAGCTGCAGTTCTTGGAGAAGATCAATAAAAACTGCTGGAGGATCAAGAAGGGCTTCGTG
CCCAACATGCAGGTTGAAGGTGTTTTCTATGTGAATGATGCTCTGGAGAAATTGATGTTTGAGGAATTAAGGAATGCCTGTCGAGGTGGT
GGTGTTGGTGGCTTCCTGCCAGCCATGAAACAGATTGGCAATGTGGCAGCCCTGCCTGGAATTGTTCATCGATCTATTGGGCTTCCTGAT
GTCCATTCAGGATATGGGTTTGCTATTGGGAACATGGCAGCCTTTGATATGAATGACCCTGAAGCAGTAGTATCCCCAGTGGCCATGCAG
CAGCCCGCCACCACCTGGCACACAGCAGGAGTGGACGACTTCGCCAGCTTCCAGCGCAAGTGGTTTGAGGTGGCCTTTGTGGCAGAAGAG
CTCGTGCACTCTGAGATTCCTGCCTTTCTCCTGCCCTGGCTGCCTAGCCGGCCAGCCTCCTATGCAAGTAGGCACAGCTCCTTTAGCCGA
AGTTTTGGAGGACGGAGCCAGGCGGCAGCACTTTTAGCTGCCACTGTCCCAGAGCAGAGGACTGTGACCCTGGATGTTGACGTGAACAAC
CGCACAGACCGGCTGGAGTGGTGCAGCTGTTATTACCATGGCAACTTTTCTCTGAATGCAGCCTTTGAGATCAAGCTGCACTGGATGGCG
GTGACCGCAGCAGTACTCTTCGAGATGGTCCAAGGTTGGCATCGGAAAGCCACCTCCTGTGGCTTCTTGTTAGTCCCAGTTTTGGAGGGG
CCTTTTGCACTGCCCAGTTACCTGTATGGCGACCCCCTTCGTGCCCAGCTCTTCATCCCACTCAACATCAGCTGCTTGCTCAAGGAGGGC
AGCGAGCACCTGTTTGATAGTTTGGGTTTGTACAAGATAAATATTCTGCCTCTGCTTTTAACTTCCCTGCTGAGAACAAGCCTCAGTATA
TCCACGTTACAGGAACAGTGTTTCTGCAGCTGCCCTACTCCAAGCGCAAGTTCTCAGGGCAGCAGCGGCGGCGGCGGAACTCCACCAGCT
CCACCAACCAGAACATGTTCTGCGAGGAGCGGGTCGGCTACAACTGGGCCTACAACACCATGCTCACCAAAACATGGCGCTCCAGCGCCA
CAGGGGATGAAAAGTTTGCTGATCGGCTGCTGAAGGACTTCACGGACTTCTGCATCAACCGTGACAACCGGCTGGTCACGTTCTGGACAA
GTTGCCTGGAGAAGATGCATGCCAGTGCCCCGTGAGGCCAGGCTGCACCTGTGCTGGGGGAAGGTGGGTGAGCCACTGCCCTCAAACCCG
GGGCGGAGGATTCCAGGCAGGCTCTAGGAGTCAGGTGTCCGTTTGCTGCTATCAGTGAGTGGGGGCCATTGTTTTTTGTTTGTTTGTTTG
TTTGTTTGTTTGTTTTTGGCCCCCACGACAAGTCTTCTACTCTAGAAGAAAGACTTTGGAAGCAGCTGCTGCTGCTGCCACCACTCCTGT
CAGCAAGTGCTCAGAGCAGGTGGGAGGCACAGATTGTCCGTGGGAGGGCTCCAGTGTCTGGGAAGAGGGCAGGCGGCCCCCATGAATGTC

>78503_78503_2_RTCB-DEPDC5_RTCB_chr22_32802649_ENST00000216038_DEPDC5_chr22_32275511_ENST00000382111_length(amino acids)=426AA_BP=141
MEGGALRSRTTRQRLFKAEPGVFATVFATMSRSYNDELQFLEKINKNCWRIKKGFVPNMQVEGVFYVNDALEKLMFEELRNACRGGGVGG
FLPAMKQIGNVAALPGIVHRSIGLPDVHSGYGFAIGNMAAFDMNDPEAVVSPVAMQQPATTWHTAGVDDFASFQRKWFEVAFVAEELVHS
EIPAFLLPWLPSRPASYASRHSSFSRSFGGRSQAAALLAATVPEQRTVTLDVDVNNRTDRLEWCSCYYHGNFSLNAAFEIKLHWMAVTAA
VLFEMVQGWHRKATSCGFLLVPVLEGPFALPSYLYGDPLRAQLFIPLNISCLLKEGSEHLFDSLGLYKINILPLLLTSLLRTSLSISTLQ

--------------------------------------------------------------
>78503_78503_3_RTCB-DEPDC5_RTCB_chr22_32802649_ENST00000216038_DEPDC5_chr22_32275511_ENST00000382112_length(transcript)=1954nt_BP=439nt
GCGCTTTGGTTCTTGGAAGGCGGTGCTCTGAGAAGCCGGACTACGCGGCAGCGGCTCTTCAAAGCGGAGCCGGGAGTTTTTGCTACAGTT
TTCGCCACCATGAGTCGCAGCTATAATGATGAGCTGCAGTTCTTGGAGAAGATCAATAAAAACTGCTGGAGGATCAAGAAGGGCTTCGTG
CCCAACATGCAGGTTGAAGGTGTTTTCTATGTGAATGATGCTCTGGAGAAATTGATGTTTGAGGAATTAAGGAATGCCTGTCGAGGTGGT
GGTGTTGGTGGCTTCCTGCCAGCCATGAAACAGATTGGCAATGTGGCAGCCCTGCCTGGAATTGTTCATCGATCTATTGGGCTTCCTGAT
GTCCATTCAGGATATGGGTTTGCTATTGGGAACATGGCAGCCTTTGATATGAATGACCCTGAAGCAGTAGTATCCCCAGTGGCCATGCAG
CAGCCCGCCACCACCTGGCACACAGCAGGAGTGGACGACTTCGCCAGCTTCCAGCGCAAGTGGTTTGAGGTGGCCTTTGTGGCAGAAGAG
CTCGTGCACTCTGAGATTCCTGCCTTTCTCCTGCCCTGGCTGCCTAGCCGGCCAGCCTCCTATGCAAGTAGGCACAGCTCCTTTAGCCGA
AGTTTTGGAGGACGGAGCCAGGCGGCAGCACTTTTAGCTGCCACTGTCCCAGAGCAGAGGACTGTGACCCTGGATGTTGACGTGAACAAC
CGCACAGACCGGCTGGAGTGGTGCAGCTGTTATTACCATGGCAACTTTTCTCTGAATGCAGCCTTTGAGATCAAGCTGCACTGGATGGCG
GTGACCGCAGCAGTACTCTTCGAGATGGTCCAAGGTTGGCATCGGAAAGCCACCTCCTGTGGCTTCTTGTTAGTCCCAGTTTTGGAGGGG
CCTTTTGCACTGCCCAGTTACCTGTATGGCGACCCCCTTCGTGCCCAGCTCTTCATCCCACTCAACATCAGCTGCTTGCTCAAGGAGGGC
AGCGAGCACCTGTTTGATAGCTTTGAACCCGAAACGTACTGGGATCGAATGCACCTCTTCCAGGAAGCCATTGCACACAGGTTTGGGTTT
GTACAAGATAAATATTCTGCCTCTGCTTTTAACTTCCCTGCTGAGAACAAGCCTCAGTATATCCACGTTACAGGAACAGTGTTTCTGCAG
CTGCCCTACTCCAAGCGCAAGTTCTCAGGGCAGCAGCGGCGGCGGCGGAACTCCACCAGCTCCACCAACCAGAACATGTTCTGCGAGGAG
CGGGTCGGCTACAACTGGGCCTACAACACCATGCTCACCAAAACATGGCGCTCCAGCGCCACAGGGGATGAAAAGTTTGCTGATCGGCTG
CTGAAGGACTTCACGGACTTCTGCATCAACCGTGACAACCGGCTGGTCACGTTCTGGACAAGTTGCCTGGAGAAGATGCATGCCAGTGCC
CCGTGAGGCCAGGCTGCACCTGTGCTGGGGGAAGGTGGGTGAGCCACTGCCCTCAAACCCGGGGCGGAGGATTCCAGGCAGGCTCTAGGA
GTCAGGTGTCCGTTTGCTGCTATCAGTGAGTGGGGGCCATTGTTTTTTGTTTGTTTGTTTGTTTGTTTGTTTGTTTTTGGCCCCCACGAC
AAGTCTTCTACTCTAGAAGAAAGACTTTGGAAGCAGCTGCTGCTGCTGCCACCACTCCTGTCAGCAAGTGCTCAGAGCAGGTGGGAGGCA
CAGATTGTCCGTGGGAGGGCTCCAGTGTCTGGGAAGAGGGCAGGCGGCCCCCATGAATGTCCTCGGAAGGGGGTGGCTCCTGGTAGCATC
CTTTTCCTTCACCATCTATGGGATATTAGGGGCAGAATCTGCCACTTCTTGCCCAGGAGTGTGCACAGATGTAAGATAATTTTGTGAAAT

>78503_78503_3_RTCB-DEPDC5_RTCB_chr22_32802649_ENST00000216038_DEPDC5_chr22_32275511_ENST00000382112_length(amino acids)=477AA_BP=141
MEGGALRSRTTRQRLFKAEPGVFATVFATMSRSYNDELQFLEKINKNCWRIKKGFVPNMQVEGVFYVNDALEKLMFEELRNACRGGGVGG
FLPAMKQIGNVAALPGIVHRSIGLPDVHSGYGFAIGNMAAFDMNDPEAVVSPVAMQQPATTWHTAGVDDFASFQRKWFEVAFVAEELVHS
EIPAFLLPWLPSRPASYASRHSSFSRSFGGRSQAAALLAATVPEQRTVTLDVDVNNRTDRLEWCSCYYHGNFSLNAAFEIKLHWMAVTAA
VLFEMVQGWHRKATSCGFLLVPVLEGPFALPSYLYGDPLRAQLFIPLNISCLLKEGSEHLFDSFEPETYWDRMHLFQEAIAHRFGFVQDK
YSASAFNFPAENKPQYIHVTGTVFLQLPYSKRKFSGQQRRRRNSTSSTNQNMFCEERVGYNWAYNTMLTKTWRSSATGDEKFADRLLKDF

--------------------------------------------------------------
>78503_78503_4_RTCB-DEPDC5_RTCB_chr22_32802649_ENST00000216038_DEPDC5_chr22_32275511_ENST00000400246_length(transcript)=1902nt_BP=439nt
GCGCTTTGGTTCTTGGAAGGCGGTGCTCTGAGAAGCCGGACTACGCGGCAGCGGCTCTTCAAAGCGGAGCCGGGAGTTTTTGCTACAGTT
TTCGCCACCATGAGTCGCAGCTATAATGATGAGCTGCAGTTCTTGGAGAAGATCAATAAAAACTGCTGGAGGATCAAGAAGGGCTTCGTG
CCCAACATGCAGGTTGAAGGTGTTTTCTATGTGAATGATGCTCTGGAGAAATTGATGTTTGAGGAATTAAGGAATGCCTGTCGAGGTGGT
GGTGTTGGTGGCTTCCTGCCAGCCATGAAACAGATTGGCAATGTGGCAGCCCTGCCTGGAATTGTTCATCGATCTATTGGGCTTCCTGAT
GTCCATTCAGGATATGGGTTTGCTATTGGGAACATGGCAGCCTTTGATATGAATGACCCTGAAGCAGTAGTATCCCCAGTGGCCATGCAG
CAGCCCGCCACCACCTGGCACACAGCAGGAGTGGACGACTTCGCCAGCTTCCAGCGCAAGTGGTTTGAGGTGGCCTTTGTGGCAGAAGAG
CTCGTGCACTCTGAGATTCCTGCCTTTCTCCTGCCCTGGCTGCCTAGCCGGCCAGCCTCCTATGCAAGTAGGCACAGCTCCTTTAGCCGA
AGTTTTGGAGGACGGAGCCAGGCGGCAGCACTTTTAGCTGCCACTGTCCCAGAGCAGAGGACTGTGACCCTGGATGTTGACGTGAACAAC
CGCACAGACCGGCTGGAGTGGTGCAGCTGTTATTACCATGGCAACTTTTCTCTGAATGCAGCCTTTGAGATCAAGCTGCACTGGATGGCG
GTGACCGCAGCAGTACTCTTCGAGATGGTCCAAGGTTGGCATCGGAAAGCCACCTCCTGTGGCTTCTTGTTAGTCCCAGTTTTGGAGGGG
CCTTTTGCACTGCCCAGTTACCTGTATGGCGACCCCCTTCGTGCCCAGCTCTTCATCCCACTCAACATCAGCTGCTTGCTCAAGGAGGGC
AGCGAGCACCTGTTTGATAGTTTGGGTTTGTACAAGATAAATATTCTGCCTCTGCTTTTAACTTCCCTGCTGAGAACAAGCCTCAGTATA
TCCACGTTACAGGAACAGTGTTTCTGCAGCTGCCCTACTCCAAGCGCAAGTTCTCAGGGCAGCAGCGGCGGCGGCGGAACTCCACCAGCT
CCACCAACCAGAACATGTTCTGCGAGGAGCGGGTCGGCTACAACTGGGCCTACAACACCATGCTCACCAAAACATGGCGCTCCAGCGCCA
CAGGGGATGAAAAGTTTGCTGATCGGCTGCTGAAGGACTTCACGGACTTCTGCATCAACCGTGACAACCGGCTGGTCACGTTCTGGACAA
GTTGCCTGGAGAAGATGCATGCCAGTGCCCCGTGAGGCCAGGCTGCACCTGTGCTGGGGGAAGGTGGGTGAGCCACTGCCCTCAAACCCG
GGGCGGAGGATTCCAGGCAGGCTCTAGGAGTCAGGTGTCCGTTTGCTGCTATCAGTGAGTGGGGGCCATTGTTTTTTGTTTGTTTGTTTG
TTTGTTTGTTTGTTTTTGGCCCCCACGACAAGTCTTCTACTCTAGAAGAAAGACTTTGGAAGCAGCTGCTGCTGCTGCCACCACTCCTGT
CAGCAAGTGCTCAGAGCAGGTGGGAGGCACAGATTGTCCGTGGGAGGGCTCCAGTGTCTGGGAAGAGGGCAGGCGGCCCCCATGAATGTC
CTCGGAAGGGGGTGGCTCCTGGTAGCATCCTTTTCCTTCACCATCTATGGGATATTAGGGGCAGAATCTGCCACTTCTTGCCCAGGAGTG
TGCACAGATGTAAGATAATTTTGTGAAATAATGTACCATAGACTCTCACCAACTGTATATACCTGTACATATCAGAAGCAAATAAAGAGC

>78503_78503_4_RTCB-DEPDC5_RTCB_chr22_32802649_ENST00000216038_DEPDC5_chr22_32275511_ENST00000400246_length(amino acids)=426AA_BP=141
MEGGALRSRTTRQRLFKAEPGVFATVFATMSRSYNDELQFLEKINKNCWRIKKGFVPNMQVEGVFYVNDALEKLMFEELRNACRGGGVGG
FLPAMKQIGNVAALPGIVHRSIGLPDVHSGYGFAIGNMAAFDMNDPEAVVSPVAMQQPATTWHTAGVDDFASFQRKWFEVAFVAEELVHS
EIPAFLLPWLPSRPASYASRHSSFSRSFGGRSQAAALLAATVPEQRTVTLDVDVNNRTDRLEWCSCYYHGNFSLNAAFEIKLHWMAVTAA
VLFEMVQGWHRKATSCGFLLVPVLEGPFALPSYLYGDPLRAQLFIPLNISCLLKEGSEHLFDSLGLYKINILPLLLTSLLRTSLSISTLQ

--------------------------------------------------------------
>78503_78503_5_RTCB-DEPDC5_RTCB_chr22_32802649_ENST00000216038_DEPDC5_chr22_32275511_ENST00000400248_length(transcript)=1975nt_BP=439nt
GCGCTTTGGTTCTTGGAAGGCGGTGCTCTGAGAAGCCGGACTACGCGGCAGCGGCTCTTCAAAGCGGAGCCGGGAGTTTTTGCTACAGTT
TTCGCCACCATGAGTCGCAGCTATAATGATGAGCTGCAGTTCTTGGAGAAGATCAATAAAAACTGCTGGAGGATCAAGAAGGGCTTCGTG
CCCAACATGCAGGTTGAAGGTGTTTTCTATGTGAATGATGCTCTGGAGAAATTGATGTTTGAGGAATTAAGGAATGCCTGTCGAGGTGGT
GGTGTTGGTGGCTTCCTGCCAGCCATGAAACAGATTGGCAATGTGGCAGCCCTGCCTGGAATTGTTCATCGATCTATTGGGCTTCCTGAT
GTCCATTCAGGATATGGGTTTGCTATTGGGAACATGGCAGCCTTTGATATGAATGACCCTGAAGCAGTAGTATCCCCAGTGGCCATGCAG
CAGCCCGCCACCACCTGGCACACAGCAGGAGTGGACGACTTCGCCAGCTTCCAGCGCAAGTGGTTTGAGGTGGCCTTTGTGGCAGAAGAG
CTCGTGCACTCTGAGATTCCTGCCTTTCTCCTGCCCTGGCTGCCTAGCCGGCCAGCCTCCTATGCAAGTAGGCACAGCTCCTTTAGCCGA
AGTTTTGGAGGACGGAGCCAGGCGGCAGCACTTTTAGCTGCCACTGTCCCAGAGCAGAGGACTGTGACCCTGGATGTTGACGTGAACAAC
CGCACAGACCGGCTGGAGTGGTGCAGCTGTTATTACCATGGCAACTTTTCTCTGAATGCAGCCTTTGAGATCAAGCTGCACTGGATGGCG
GTGACCGCAGCAGTACTCTTCGAGATGGTCCAAGGTTGGCATCGGAAAGCCACCTCCTGTGGCTTCTTGTTAGTCCCAGTTTTGGAGGGG
CCTTTTGCACTGCCCAGTTACCTGTATGGCGACCCCCTTCGTGCCCAGCTCTTCATCCCACTCAACATCAGCTGCTTGCTCAAGGAGGGC
AGCGAGCACCTGTTTGATAGCTTTGAACCCGAAACGTACTGGGATCGAATGCACCTCTTCCAGGAAGCCATTGCACACAGGTTTGGGTTT
GTACAAGATAAATATTCTGCCTCTGCTTTTAACTTCCCTGCTGAGAACAAGCCTCAGTATATCCACGTTACAGGAACAGTGTTTCTGCAG
CTGCCCTACTCCAAGCGCAAGTTCTCAGGGCAGCAGCGGCGGCGGCGGAACTCCACCAGCTCCACCAACCAGAACATGTTCTGCGAGGAG
CGGGTCGGCTACAACTGGGCCTACAACACCATGCTCACCAAAACATGGCGCTCCAGCGCCACAGGGGATGAAAAGTTTGCTGATCGGCTG
CTGAAGGACTTCACGGACTTCTGCATCAACCGTGACAACCGGCTGGTCACGTTCTGGACAAGTTGCCTGGAGAAGATGCATGCCAGTGCC
CCGTGAGGCCAGGCTGCACCTGTGCTGGGGGAAGGTGGGTGAGCCACTGCCCTCAAACCCGGGGCGGAGGATTCCAGGCAGGCTCTAGGA
GTCAGGTGTCCGTTTGCTGCTATCAGTGAGTGGGGGCCATTGTTTTTTGTTTGTTTGTTTGTTTGTTTGTTTGTTTTTGGCCCCCACGAC
AAGTCTTCTACTCTAGAAGAAAGACTTTGGAAGCAGCTGCTGCTGCTGCCACCACTCCTGTCAGCAAGTGCTCAGAGCAGGTGGGAGGCA
CAGATTGTCCGTGGGAGGGCTCCAGTGTCTGGGAAGAGGGCAGGCGGCCCCCATGAATGTCCTCGGAAGGGGGTGGCTCCTGGTAGCATC
CTTTTCCTTCACCATCTATGGGATATTAGGGGCAGAATCTGCCACTTCTTGCCCAGGAGTGTGCACAGATGTAAGATAATTTTGTGAAAT

>78503_78503_5_RTCB-DEPDC5_RTCB_chr22_32802649_ENST00000216038_DEPDC5_chr22_32275511_ENST00000400248_length(amino acids)=477AA_BP=141
MEGGALRSRTTRQRLFKAEPGVFATVFATMSRSYNDELQFLEKINKNCWRIKKGFVPNMQVEGVFYVNDALEKLMFEELRNACRGGGVGG
FLPAMKQIGNVAALPGIVHRSIGLPDVHSGYGFAIGNMAAFDMNDPEAVVSPVAMQQPATTWHTAGVDDFASFQRKWFEVAFVAEELVHS
EIPAFLLPWLPSRPASYASRHSSFSRSFGGRSQAAALLAATVPEQRTVTLDVDVNNRTDRLEWCSCYYHGNFSLNAAFEIKLHWMAVTAA
VLFEMVQGWHRKATSCGFLLVPVLEGPFALPSYLYGDPLRAQLFIPLNISCLLKEGSEHLFDSFEPETYWDRMHLFQEAIAHRFGFVQDK
YSASAFNFPAENKPQYIHVTGTVFLQLPYSKRKFSGQQRRRRNSTSSTNQNMFCEERVGYNWAYNTMLTKTWRSSATGDEKFADRLLKDF

--------------------------------------------------------------
>78503_78503_6_RTCB-DEPDC5_RTCB_chr22_32802649_ENST00000216038_DEPDC5_chr22_32275511_ENST00000400249_length(transcript)=1963nt_BP=439nt
GCGCTTTGGTTCTTGGAAGGCGGTGCTCTGAGAAGCCGGACTACGCGGCAGCGGCTCTTCAAAGCGGAGCCGGGAGTTTTTGCTACAGTT
TTCGCCACCATGAGTCGCAGCTATAATGATGAGCTGCAGTTCTTGGAGAAGATCAATAAAAACTGCTGGAGGATCAAGAAGGGCTTCGTG
CCCAACATGCAGGTTGAAGGTGTTTTCTATGTGAATGATGCTCTGGAGAAATTGATGTTTGAGGAATTAAGGAATGCCTGTCGAGGTGGT
GGTGTTGGTGGCTTCCTGCCAGCCATGAAACAGATTGGCAATGTGGCAGCCCTGCCTGGAATTGTTCATCGATCTATTGGGCTTCCTGAT
GTCCATTCAGGATATGGGTTTGCTATTGGGAACATGGCAGCCTTTGATATGAATGACCCTGAAGCAGTAGTATCCCCAGTGGCCATGCAG
CAGCCCGCCACCACCTGGCACACAGCAGGAGTGGACGACTTCGCCAGCTTCCAGCGCAAGTGGTTTGAGGTGGCCTTTGTGGCAGAAGAG
CTCGTGCACTCTGAGATTCCTGCCTTTCTCCTGCCCTGGCTGCCTAGCCGGCCAGCCTCCTATGCAAGTAGGCACAGCTCCTTTAGCCGA
AGTTTTGGAGGACGGAGCCAGGCGGCAGCACTTTTAGCTGCCACTGTCCCAGAGCAGAGGACTGTGACCCTGGATGTTGACGTGAACAAC
CGCACAGACCGGCTGGAGTGGTGCAGCTGTTATTACCATGGCAACTTTTCTCTGAATGCAGCCTTTGAGATCAAGCTGCACTGGATGGCG
GTGACCGCAGCAGTACTCTTCGAGATGGTCCAAGGTTGGCATCGGAAAGCCACCTCCTGTGGCTTCTTGTTAGTCCCAGTTTTGGAGGGG
CCTTTTGCACTGCCCAGTTACCTGTATGGCGACCCCCTTCGTGCCCAGCTCTTCATCCCACTCAACATCAGCTGCTTGCTCAAGGAGGGC
AGCGAGCACCTGTTTGATAGCTTTGAACCCGAAACGTACTGGGATCGAATGCACCTCTTCCAGGAAGCCATTGCACACAGGTTTGGGTTT
GTACAAGATAAATATTCTGCCTCTGCTTTTAACTTCCCTGCTGAGAACAAGCCTCAGTATATCCACGTTACAGGAACAGTGTTTCTGCAG
CTGCCCTACTCCAAGCGCAAGTTCTCAGGGCAGCAGCGGCGGCGGCGGAACTCCACCAGCTCCACCAACCAGAACATGTTCTGCGAGGAG
CGGGTCGGCTACAACTGGGCCTACAACACCATGCTCACCAAAACATGGCGCTCCAGCGCCACAGGGGATGAAAAGTTTGCTGATCGGCTG
CTGAAGGACTTCACGGACTTCTGCATCAACCGTGACAACCGGCTGGTCACGTTCTGGACAAGTTGCCTGGAGAAGATGCATGCCAGTGCC
CCGTGAGGCCAGGCTGCACCTGTGCTGGGGGAAGGTGGGTGAGCCACTGCCCTCAAACCCGGGGCGGAGGATTCCAGGCAGGCTCTAGGA
GTCAGGTGTCCGTTTGCTGCTATCAGTGAGTGGGGGCCATTGTTTTTTGTTTGTTTGTTTGTTTGTTTGTTTGTTTTTGGCCCCCACGAC
AAGTCTTCTACTCTAGAAGAAAGACTTTGGAAGCAGCTGCTGCTGCTGCCACCACTCCTGTCAGCAAGTGCTCAGAGCAGGTGGGAGGCA
CAGATTGTCCGTGGGAGGGCTCCAGTGTCTGGGAAGAGGGCAGGCGGCCCCCATGAATGTCCTCGGAAGGGGGTGGCTCCTGGTAGCATC
CTTTTCCTTCACCATCTATGGGATATTAGGGGCAGAATCTGCCACTTCTTGCCCAGGAGTGTGCACAGATGTAAGATAATTTTGTGAAAT

>78503_78503_6_RTCB-DEPDC5_RTCB_chr22_32802649_ENST00000216038_DEPDC5_chr22_32275511_ENST00000400249_length(amino acids)=477AA_BP=141
MEGGALRSRTTRQRLFKAEPGVFATVFATMSRSYNDELQFLEKINKNCWRIKKGFVPNMQVEGVFYVNDALEKLMFEELRNACRGGGVGG
FLPAMKQIGNVAALPGIVHRSIGLPDVHSGYGFAIGNMAAFDMNDPEAVVSPVAMQQPATTWHTAGVDDFASFQRKWFEVAFVAEELVHS
EIPAFLLPWLPSRPASYASRHSSFSRSFGGRSQAAALLAATVPEQRTVTLDVDVNNRTDRLEWCSCYYHGNFSLNAAFEIKLHWMAVTAA
VLFEMVQGWHRKATSCGFLLVPVLEGPFALPSYLYGDPLRAQLFIPLNISCLLKEGSEHLFDSFEPETYWDRMHLFQEAIAHRFGFVQDK
YSASAFNFPAENKPQYIHVTGTVFLQLPYSKRKFSGQQRRRRNSTSSTNQNMFCEERVGYNWAYNTMLTKTWRSSATGDEKFADRLLKDF

--------------------------------------------------------------
>78503_78503_7_RTCB-DEPDC5_RTCB_chr22_32802649_ENST00000216038_DEPDC5_chr22_32275511_ENST00000535622_length(transcript)=1699nt_BP=439nt
GCGCTTTGGTTCTTGGAAGGCGGTGCTCTGAGAAGCCGGACTACGCGGCAGCGGCTCTTCAAAGCGGAGCCGGGAGTTTTTGCTACAGTT
TTCGCCACCATGAGTCGCAGCTATAATGATGAGCTGCAGTTCTTGGAGAAGATCAATAAAAACTGCTGGAGGATCAAGAAGGGCTTCGTG
CCCAACATGCAGGTTGAAGGTGTTTTCTATGTGAATGATGCTCTGGAGAAATTGATGTTTGAGGAATTAAGGAATGCCTGTCGAGGTGGT
GGTGTTGGTGGCTTCCTGCCAGCCATGAAACAGATTGGCAATGTGGCAGCCCTGCCTGGAATTGTTCATCGATCTATTGGGCTTCCTGAT
GTCCATTCAGGATATGGGTTTGCTATTGGGAACATGGCAGCCTTTGATATGAATGACCCTGAAGCAGTAGTATCCCCAGTGGCCATGCAG
CAGCCCGCCACCACCTGGCACACAGCAGGAGTGGACGACTTCGCCAGCTTCCAGCGCAAGTGGTTTGAGGTGGCCTTTGTGGCAGAAGAG
CTCGTGCACTCTGAGATTCCTGCCTTTCTCCTGCCCTGGCTGCCTAGCCGGCCAGCCTCCTATGCAAGTAGGCACAGCTCCTTTAGCCGA
AGTTTTGGAGGACGGAGCCAGGCGGCAGCACTTTTAGCTGCCACTGTCCCAGAGCAGAGGACTGTGACCCTGGATGTTGACGTGAACAAC
CGCACAGACCGGCTGGAGTGGTGCAGCTGTTATTACCATGGCAACTTTTCTCTGAATGCAGCCTTTGAGATCAAGCTGCACTGGATGGCG
GTGACCGCAGCAGTACTCTTCGAGATGGTCCAAGGTTGGCATCGGAAAGCCACCTCCTGTGGCTTCTTGTTAGTCCCAGTTTTGGAGGGG
CCTTTTGCACTGCCCAGTTACCTGTATGGCGACCCCCTTCGTGCCCAGCTCTTCATCCCACTCAACATCAGCTGCTTGCTCAAGGAGGGC
AGCGAGCACCTGTTTGATAGCTTTGAACCCGAAACGTACTGGGATCGAATGCACCTCTTCCAGGAAGCCATTGCACACAGGTTTGGGTTT
GTACAAGATAAATATTCTGCCTCTGCTTTTAACTTCCCTGCTGAGAACAAGCCTCAGTATATCCACGTTACAGGAACAGTGTTTCTGCAG
CTGCCCTACTCCAAGCGCAAGTTCTCAGGGCAGCAGCGGCGGCGGCGGAACTCCACCAGCTCCACCAACCAGAACATGTTCTGCGAGGAG
CGGGTCGGCTACAACTGGGCCTACAACACCATGCTCACCAAAACATGGCGCTCCAGCGCCACAGGGGATGAAAAGTTTGCTGATCGGCTG
CTGAAGGACTTCACGGACTTCTGCATCAACCGTGACAACCGGCTGGTCACGTTCTGGACAAGTTGCCTGGAGAAGATGCATGCCAGTGCC
CCGTGAGGCCAGGCTGCACCTGTGCTGGGGGAAGGTGGGTGAGCCACTGCCCTCAAACCCGGGGCGGAGGATTCCAGGCAGGCTCTAGGA
GTCAGGTGTCCGTTTGCTGCTATCAGTGAGTGGGGGCCATTGTTTTTTGTTTGTTTGTTTGTTTGTTTGTTTGTTTTTGGCCCCCACGAC

>78503_78503_7_RTCB-DEPDC5_RTCB_chr22_32802649_ENST00000216038_DEPDC5_chr22_32275511_ENST00000535622_length(amino acids)=477AA_BP=141
MEGGALRSRTTRQRLFKAEPGVFATVFATMSRSYNDELQFLEKINKNCWRIKKGFVPNMQVEGVFYVNDALEKLMFEELRNACRGGGVGG
FLPAMKQIGNVAALPGIVHRSIGLPDVHSGYGFAIGNMAAFDMNDPEAVVSPVAMQQPATTWHTAGVDDFASFQRKWFEVAFVAEELVHS
EIPAFLLPWLPSRPASYASRHSSFSRSFGGRSQAAALLAATVPEQRTVTLDVDVNNRTDRLEWCSCYYHGNFSLNAAFEIKLHWMAVTAA
VLFEMVQGWHRKATSCGFLLVPVLEGPFALPSYLYGDPLRAQLFIPLNISCLLKEGSEHLFDSFEPETYWDRMHLFQEAIAHRFGFVQDK
YSASAFNFPAENKPQYIHVTGTVFLQLPYSKRKFSGQQRRRRNSTSSTNQNMFCEERVGYNWAYNTMLTKTWRSSATGDEKFADRLLKDF

--------------------------------------------------------------
>78503_78503_8_RTCB-DEPDC5_RTCB_chr22_32802649_ENST00000451746_DEPDC5_chr22_32275511_ENST00000382105_length(transcript)=1945nt_BP=421nt
GGCGGTGCTCTGAGAAGCCGGACTACGCGGCAGCGGCTCTTCAAAGCGGAGCCGGGAGTTTTTGCTACAGTTTTCGCCACCATGAGTCGC
AGCTATAATGATGAGCTGCAGTTCTTGGAGAAGATCAATAAAAACTGCTGGAGGATCAAGAAGGGCTTCGTGCCCAACATGCAGGTTGAA
GGTGTTTTCTATGTGAATGATGCTCTGGAGAAATTGATGTTTGAGGAATTAAGGAATGCCTGTCGAGGTGGTGGTGTTGGTGGCTTCCTG
CCAGCCATGAAACAGATTGGCAATGTGGCAGCCCTGCCTGGAATTGTTCATCGATCTATTGGGCTTCCTGATGTCCATTCAGGATATGGG
TTTGCTATTGGGAACATGGCAGCCTTTGATATGAATGACCCTGAAGCAGTAGTATCCCCAGTGGCCATGCAGCAGCCCGCCACCACCTGG
CACACAGCAGGAGTGGACGACTTCGCCAGCTTCCAGCGCAAGTGGTTTGAGGTGGCCTTTGTGGCAGAAGAGCTCGTGCACTCTGAGATT
CCTGCCTTTCTCCTGCCCTGGCTGCCTAGCCGGCCAGCCTCCTATGCAAGTAGGCACAGCTCCTTTAGCCGAAGTTTTGGAGGACGGAGC
CAGGCGGCAGCACTTTTAGCTGCCACTGTCCCAGAGCAGAGGACTGTGACCCTGGATGTTGACGTGAACAACCGCACAGACCGGCTGGAG
TGGTGCAGCTGTTATTACCATGGCAACTTTTCTCTGAATGCAGCCTTTGAGATCAAGCTGCACTGGATGGCGGTGACCGCAGCAGTACTC
TTCGAGATGGTCCAAGGTTGGCATCGGAAAGCCACCTCCTGTGGCTTCTTGTTAGTCCCAGTTTTGGAGGGGCCTTTTGCACTGCCCAGT
TACCTGTATGGCGACCCCCTTCGTGCCCAGCTCTTCATCCCACTCAACATCAGCTGCTTGCTCAAGGAGGGCAGCGAGCACCTGTTTGAT
AGCTTTGAACCCGAAACGTACTGGGATCGAATGCACCTCTTCCAGGAAGCCATTGCACACAGGTTTGGGTTTGTACAAGATAAATATTCT
GCCTCTGCTTTTAACTTCCCTGCTGAGAACAAGCCTCAGTATATCCACGTTACAGGAACAGTGTTTCTGCAGCTGCCCTACTCCAAGCGC
AAGTTCTCAGGGCAGCAGCGGCGGCGGCGGAACTCCACCAGCTCCACCAACCAGAACATGTTCTGCGAGGAGCGGGTCGGCTACAACTGG
GCCTACAACACCATGCTCACCAAAACATGGCGCTCCAGCGCCACAGGGGATGAAAAGTTTGCTGATCGGCTGCTGAAGGACTTCACGGAC
TTCTGCATCAACCGTGACAACCGGCTGGTCACGTTCTGGACAAGTTGCCTGGAGAAGATGCATGCCAGTGCCCCGTGAGGCCAGGCTGCA
CCTGTGCTGGGGGAAGGTGGGTGAGCCACTGCCCTCAAACCCGGGGCGGAGGATTCCAGGCAGGCTCTAGGAGTCAGGTGTCCGTTTGCT
GCTATCAGTGAGTGGGGGCCATTGTTTTTTGTTTGTTTGTTTGTTTGTTTGTTTGTTTTTGGCCCCCACGACAAGTCTTCTACTCTAGAA
GAAAGACTTTGGAAGCAGCTGCTGCTGCTGCCACCACTCCTGTCAGCAAGTGCTCAGAGCAGGTGGGAGGCACAGATTGTCCGTGGGAGG
GCTCCAGTGTCTGGGAAGAGGGCAGGCGGCCCCCATGAATGTCCTCGGAAGGGGGTGGCTCCTGGTAGCATCCTTTTCCTTCACCATCTA
TGGGATATTAGGGGCAGAATCTGCCACTTCTTGCCCAGGAGTGTGCACAGATGTAAGATAATTTTGTGAAATAATGTACCATAGACTCTC

>78503_78503_8_RTCB-DEPDC5_RTCB_chr22_32802649_ENST00000451746_DEPDC5_chr22_32275511_ENST00000382105_length(amino acids)=472AA_BP=136
MRSRTTRQRLFKAEPGVFATVFATMSRSYNDELQFLEKINKNCWRIKKGFVPNMQVEGVFYVNDALEKLMFEELRNACRGGGVGGFLPAM
KQIGNVAALPGIVHRSIGLPDVHSGYGFAIGNMAAFDMNDPEAVVSPVAMQQPATTWHTAGVDDFASFQRKWFEVAFVAEELVHSEIPAF
LLPWLPSRPASYASRHSSFSRSFGGRSQAAALLAATVPEQRTVTLDVDVNNRTDRLEWCSCYYHGNFSLNAAFEIKLHWMAVTAAVLFEM
VQGWHRKATSCGFLLVPVLEGPFALPSYLYGDPLRAQLFIPLNISCLLKEGSEHLFDSFEPETYWDRMHLFQEAIAHRFGFVQDKYSASA
FNFPAENKPQYIHVTGTVFLQLPYSKRKFSGQQRRRRNSTSSTNQNMFCEERVGYNWAYNTMLTKTWRSSATGDEKFADRLLKDFTDFCI

--------------------------------------------------------------

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Fusion Gene PPI Analysis for RTCB-DEPDC5


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for RTCB-DEPDC5


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for RTCB-DEPDC5


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource