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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:RTCB-FAM83F (FusionGDB2 ID:78504)

Fusion Gene Summary for RTCB-FAM83F

Fusion gene summary

Fusion gene information	Fusion gene name: RTCB-FAM83F
	Fusion gene ID: 78504
		Hgene	Tgene
	Gene symbol	RTCB	FAM83F
	Gene ID	51493	113828
	Gene name	RNA 2',3'-cyclic phosphate and 5'-OH ligase	family with sequence similarity 83 member F
	Synonyms	C22orf28\|DJ149A16.6\|FAAP\|HSPC117	-
	Cytomap	22q12.3	22q13.1
	Type of gene	protein-coding	protein-coding
	Description	tRNA-splicing ligase RtcB homologankyrin repeat domain 54focal adhesion-associated protein	protein FAM83F
	Modification date	20200313	20200313
	UniProtAcc	Q9Y3I0	Q8NEG4
	Ensembl transtripts involved in fusion gene	ENST00000216038, ENST00000451746, ENST00000476619,	ENST00000473717, ENST00000488874, ENST00000333407,
Fusion gene scores	* DoF score	3 X 3 X 3=27	2 X 2 X 2=8
	# samples	4	2
	** MAII score	log2(4/27*10)=0.567040592723894 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0	log2(2/8*10)=1.32192809488736
Context	PubMed: RTCB [Title/Abstract] AND FAM83F [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	RTCB(32802649)-FAM83F(40425520), # samples:1
Anticipated loss of major functional domain due to fusion event.	RTCB-FAM83F seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	RTCB	GO:0006388	tRNA splicing, via endonucleolytic cleavage and ligation	21311021\|24870230

Fusion gene breakpoints across RTCB (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across FAM83F (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	SKCM	TCGA-EB-A3Y6-01A	RTCB	chr22	32802649	-	FAM83F	chr22	40425520	+

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Fusion Gene ORF analysis for RTCB-FAM83F

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000216038	ENST00000473717	RTCB	chr22	32802649	-	FAM83F	chr22	40425520	+
5CDS-intron	ENST00000216038	ENST00000488874	RTCB	chr22	32802649	-	FAM83F	chr22	40425520	+
5CDS-intron	ENST00000451746	ENST00000473717	RTCB	chr22	32802649	-	FAM83F	chr22	40425520	+
5CDS-intron	ENST00000451746	ENST00000488874	RTCB	chr22	32802649	-	FAM83F	chr22	40425520	+
5UTR-3CDS	ENST00000476619	ENST00000333407	RTCB	chr22	32802649	-	FAM83F	chr22	40425520	+
5UTR-intron	ENST00000476619	ENST00000473717	RTCB	chr22	32802649	-	FAM83F	chr22	40425520	+
5UTR-intron	ENST00000476619	ENST00000488874	RTCB	chr22	32802649	-	FAM83F	chr22	40425520	+
Frame-shift	ENST00000451746	ENST00000333407	RTCB	chr22	32802649	-	FAM83F	chr22	40425520	+
In-frame	ENST00000216038	ENST00000333407	RTCB	chr22	32802649	-	FAM83F	chr22	40425520	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000216038

RTCB

chr22

32802649

ENST00000333407

FAM83F

chr22

40425520

14453

439

7095

7733

212

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000216038	ENST00000333407	RTCB	chr22	32802649	-	FAM83F	chr22	40425520	+	0.3712507	0.62874925

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Fusion Genomic Features for RTCB-FAM83F

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
RTCB	chr22	32802648	-	FAM83F	chr22	40425519	+	0.9122896	0.08771036
RTCB	chr22	32802648	-	FAM83F	chr22	40425519	+	0.9122896	0.08771036

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for RTCB-FAM83F

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr22:32802649/chr22:40425520)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
RTCB Q9Y3I0	FAM83F Q8NEG4
FUNCTION: Catalytic subunit of the tRNA-splicing ligase complex that acts by directly joining spliced tRNA halves to mature-sized tRNAs by incorporating the precursor-derived splice junction phosphate into the mature tRNA as a canonical 3',5'-phosphodiester. May act as an RNA ligase with broad substrate specificity, and may function toward other RNAs. {ECO:0000255\|HAMAP-Rule:MF_03144, ECO:0000269\|PubMed:21311021, ECO:0000269\|PubMed:24870230}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

RTCB

chr22:32802649

chr22:40425520

ENST00000216038

226_230

113

506.0

Nucleotide binding

GMP

Hgene

RTCB

chr22:32802649

chr22:40425520

ENST00000216038

353_354

113

506.0

Nucleotide binding

GMP

Hgene

RTCB

chr22:32802649

chr22:40425520

ENST00000216038

402_405

113

506.0

Nucleotide binding

GMP

Hgene

RTCB

chr22:32802649

chr22:40425520

ENST00000216038

428_431

113

506.0

Nucleotide binding

GMP

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Fusion Gene Sequence for RTCB-FAM83F

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>78504_78504_1_RTCB-FAM83F_RTCB_chr22_32802649_ENST00000216038_FAM83F_chr22_40425520_ENST00000333407_length(transcript)=14453nt_BP=439nt
GCGCTTTGGTTCTTGGAAGGCGGTGCTCTGAGAAGCCGGACTACGCGGCAGCGGCTCTTCAAAGCGGAGCCGGGAGTTTTTGCTACAGTT
TTCGCCACCATGAGTCGCAGCTATAATGATGAGCTGCAGTTCTTGGAGAAGATCAATAAAAACTGCTGGAGGATCAAGAAGGGCTTCGTG
CCCAACATGCAGGTTGAAGGTGTTTTCTATGTGAATGATGCTCTGGAGAAATTGATGTTTGAGGAATTAAGGAATGCCTGTCGAGGTGGT
GGTGTTGGTGGCTTCCTGCCAGCCATGAAACAGATTGGCAATGTGGCAGCCCTGCCTGGAATTGTTCATCGATCTATTGGGCTTCCTGAT
GTCCATTCAGGATATGGGTTTGCTATTGGGAACATGGCAGCCTTTGATATGAATGACCCTGAAGCAGTAGTATCCCCAGGTAAAACAAGT
CCCAGTTCTGCCAAGCCTAGCAACTGTGTGATTTCCTGAGCTGCGGGATGGTGGTGGGCAGGACGTGTGGATGCCTGCCTGCCCTGCCCT
GTGCTGTGGAGAGCGCAGGTCGCACACTGCACCAGTTTGCACATCAGACGCCAACTGGCCTTCTGCCCTGCAGCCTCCGTCCTGGCCTCA
GGGACGCTGGATCCCAAATGAGAGGGTCCGAAGCATCTCAGTCACACGCCTCCACCGGACTGTCGGTGGCTGGGCAGGGGTCAGTGCCAC
GGCCTCCTTGTTTACATGAAGTGGAAGCTTGACCAGTGTCTGCTCGCCTTTGTGCCCCACCCCCTCCGCTGATTGCCAGATGGGGTGAGG
GCCCATTCTTTAAACCTTTATGGGGTGGGGTGTCTGGGGCAGCTGCAGTGGCTTCTCCTTTCCCAGGCTTCCTGGTGCTTCTGGTTCCCC
ACGCCACTCCCCACCCAAGAGATTGGTGGAATAAAAGGGAAGAGGGCAGGGCCCTGAGCCTGGGATCCCAAGTTCCAGTCTTTCTCTAGC
CTCTGAACTCCAGATGTAAGGTGCAGCTGGAACTGCAGGGGCACTGGCTGCAGTGGCCTTCCTGGCCCCATCCCTGCAGGCTCCTGAACT
AGACTTGAATGAGGGTAAGATCCTGCGGCCTCCCGCAGTGGGGGCAGAATTTGACACTGCTTTTCTGAGAGCGCTCGCACTGAGGTCTCT
TTTTCCCTGCCCAGTGCCGTCCTGGCAGTCTCGGCATGGGTGGTTGAGACCTCCTTGGCTGCTGCCTGCTGCGGGCCTATGTGGGGGTCC
TTACAGGGCCTTTACCTGGGACTGCTCCTTCCCTCAGTCAGTAAACTTTGGTTTACAGCCCAAGGCAGGGAGGGAGCTTGGCTGAGAGGG
GATTGGGGGTGTGGGAGGCTGGGCCCTGAGGACAGGAGCATTTGCCTTTTCTCCCTCAACTCTAACGGGGTCCTCGGACCCCTTCACCAA
CCAGGGCTTCCAGGTTACACTTTGGCCAGACTGGCCTTTGCCTCCTGCGAGAGTCAGGCCATTTTTAGGAGCCTGTGCCTCGCCAGAGCA
GGTCAGCCTAATGGCCATGAGGCTGAGCTGGGAGGCCCAGTAAGCAATTCCATTCTGCCTTCCCCACTTGGGTGACTGGAGAGGGCCGAG
GAGAGTTTGTGAATGGACCTGGGAGAAATTGCCAAACTGCAGACTCTGTGAGCCGGCCCTGCCGGCAGGGCGATGGGGGATCCAAGCCCT
GTGGAAGAGCCATGCAGCGGACTTTCTTGCCCTCTGACCTCTGAACCAAACTCTCATCCTCTTTCTTTCCTTCTAAAAAACCCTAGGACA
CTACCAGCACCTGGGGGAGGGGTACAGATGTCTGCAAGGCAGCTGATGTGAGAGCAAGAAAAGGGGCTGCTCTGGCTGGGCTGTGGGAGC
CAGGCATTGCTTCTGAGGAAGCAGGAAGTGGGGACCACATGTGGCGGCCATTGAGGAGATGCAATCTCTCTGGCAGTGGGGAGGGGAAGG
GAAAGGAAGGGTGAGCCTGTCCCCAGGGTCTTCTCTGTTAATCCCAAGGCTGGCTTCTAGGGCGTGTGGAGAAGGGACTCTGGCCCACCT
CCCTGAGCTTTTATGAAGGTGAAATGCTTCTGGGAAGTGTTTCCTTAGGCACCAAGACCAGGCAGTGTGGCATGAGCTCATTCTGGAGGG
GAGGGAAGGGAGAGAGGGGGGAGGTGGGATGTGGGGGTGTTACACCTCAGCTCGAGGCGGACACCTTGAAGGTATGGGACATGAAATGTG
TAAACTGCAACGCGGCAAAGAGATCACTCTCTGGTGTGGAGGGTGGGTGTCTCTGGGGATTAGGGAGGCAGCCTGGGGAAGGGACCGGCC
TCCAAGCAAGTCAGCCAAGGGCATCTGTGCCTCCCCTGCCAGAAGAGCAGGCCCTGCTTTGTCCCTTTACCTCCTCTAGGCCCAAAGCAC
ACCCAGGTCCCTCCCCTGCCCTGACATCTAATCTGGGAGGATCCCTGATTGGAATCTCCAAGTCACCACAGCCTTGAGCCAGGCCTTCCT
TTCTGCCTCAGTTTCTCCATGTGCCAAGATGGCGTTTTTCACACTTTCTTAGTAGAAATGATGGGGAGACCATATGTTAGGAAGCAAGTT
GGCATAGTGGGAAGAGGGCCAGCCACAAGGCAGGAGTGCCCAGGCAGGGTGCCTCTCCCTGCTGGCCTGTGTCCTCGTCCTTATAGCAGT
GTGGACAAGATGGTGTCGGCACCCCCCGCTCCAAAAGGCTTGAGACAGAAACTGTAGTCCGAGATGGCAAGGATTTTGAACTCACAAAAT
GCAGCTCTTCATGTTTGCCTGTCTGCCTAGGCACCGGCCCACTCTGTTCTGCCTCTTGGCTTCTCAGCTGTGAGTACGCCTGCCCTCTGT
TCCAGCACTTGCACATACTTTGTGAAGCAGTCTCTTACTCATCAAATCTCAAGGGTACATCTGGCCCTCCCAGTTGGATGGCAAGTTCAA
GGGTGGATCATGCCCTTGGTCCCTGCACAGCAGCTTCTGCAAGGCTGGTTACATTGGAAGGGCTCTAGGAGGAACAGGATAAGGCAGCAC
TCTCGGGGCTGGGGTCTGGCTTCACTGCACCCCCCTCCCACCCCACACCACCACCAAGCTGCTGTCTTTCTGAGTCAGCTTCTGTAGGGT
AAGTGTTCACAGCTGGTGCAGCTCTTTGGGAAACCTAACCTCCCAGTGAGCTGAGCCCCTGGTGCGGCCGCCACGCTTGCTTCTGCCCCA
CAAGGGCAGTAAGCACAGGACTTCTGGATGGATCTGGGAGCCTGCCCCTTGGGATTTGGCAAAACTTCCCATCTCCTTAGCTACCTGTCC
TTAATCTTATCCCTGACCCCTCGAGGGCTTTCAAGATAGCCTCTGTTAACATCACTACCCTCTGCCTGTGTAGAACTTTATAGAAAGGCT
AGGCAAAAAATGAGACCCAGAGATATGGAAGAAACTGGCCAAAGAGGGGAAAGTGGGCTATTTCTTTTTTTTTTTTCTTTTTTTTTTCTG
AGACAGAGTCTCACCCTGTTGCCCAGGCTGGAGTGCAGTGACAGCGATCTTGGCTCACTGCAAGCTCCGCCTCCCGGGTTCACGCCATTC
TTCTGCCTCAGCCTCCTGAGCAGCTATGACTACAGGTGCCCACCACCATGCCTGGCTAATTTTTTTATATTTTTATTAGAGACAGGGTTT
CACCATGTTAGCCAGGTTGGTCTTGATCTCCTGACCTTGTGATCCGCCCGCCTTGGCCTCCCAAAGTGCTGGGATTACAGGCCACCGTAC
CCGGCCAGGCTATTTTTTTGTTTTGTTTTTGTTTACTACTGTATTGCTTTTCTCTTTTTCATATTTATTGAGCACCTACTATATGCCAGT
CACCATGCTAGATGCTTTAGTAACATGAAGGTTTCAAACTAAGAAAAGCTCAACAAAGAGCCCTTTAGAAAGGTAACAGTTTTCCTGTGT
ATTGGGGGAGTGGGTCTCATAAGGTTGTATGATGAGAAGCGCAAGTAATTGTTTTGTTTTTTTTTTGAGACAATGTCTTGCTCTGTCGAT
CAGGCTGGAGTGCAGTGGCGTCATCTCAGCTCGCTACAACCTCCACCTCCTGGGTTTAAGTGATTCTCTGGCCTCAGCCTCCTGAGTAGC
TGAGATTACAGGCACGCGCCACCACGCCCGGCTAATTTTTGTATTTTTAGTAGAGACAGGGTTTCACTATGTTGGTCAGGCTGATCTTGA
ACTCCCGGCCTCAGGTGATCTGCCTGCCTTGGCCTCCCAAACTGCTGGGATTACAGGCATGAGCCACCACGCCCAGCCTGGCTAAGGTTC
ATTATCCCCATCTTTCAGATGAGGAGGCACACAACTCTCCCCAGATCCCACGTCACAGAGAATGCAGGTCTGAGTCTGTTCCTTGAGCTC
AGGGTCTTGGCAATGGTGATGCTTTGGAGCTGCAGAATCCTCTGTTGGGGATGGGGCTGCCCTGTGCATTATAGTACGTTTAGCAACATC
CCTAGCTTCCACCTACTAAATGCCACTAGCACTCCTTCAGATGAGACCACCAAAAATGTCTCCAGATGTTACCACATGTCCCCTGGGGGG
TAAAAGTGCCCCCGTTGAGAGCACTGGCTCTTTTCTTCACAGTCCTGACCTGGTGGCCTGCACAGGCCACTTCTCCGAAGTGTTTCAATG
CACTCTCTGCCCTGGGTACCTTGGACACAGCACCCTGGCCCAGAGAGGTTGGCTGACTTGCCTGAGACGCTGCTTCCTGGGAGACGCAGT
AGCATCTTTCCTTTCTGTTCTGGTTATCTTTCTTAGTTCTTTACCACCTTATATTCCCCATGACAGGTGTGTTTATGTACACACATCTGC
CTCACTCCACTCAGCTCCCTGTCAGGTTTCCTGCCAGTCTGTCCCTCTTCCTTCAGGCTCAGCTACGTCCTGCACAGACAGTACCACTGC
ACATACCTGTGTGTGCCCAGCGGTGGACCCACCTCCAAAAGCAGCCAGTGCTGACAGCAGAGAGCCTTCCACACTCAAGTCAGGCCAAGC
AGGAATCGCTACCTGCCTGTCATGACCACATTCTCAGTGAACATTGACAAAGCCCCCTTAGCAGCTAATTAGCCCTGCCGTGCGCTAGGG
ATGCAATTTCTCATCTGGCAGTGCGCCACACTCCTGCCTCCCTGCCCAAAGGACGTAGTGGCTGCTGCTGATCGTCTGCACTGCTGTTCC
AGGGGCAGGAGGTTTGCTGCAAATCAGGTACCCCCAGCTCAGTGAGCAGAACCAGTCCAAGGTTGAGTGAGGAGAAGGGCAAGAAGGGCA
GGCACAGCCGTGAGTATGTTCTGGGGCTAAGTAACCATGAGATCAGCCCAGAGACCTTGCACAGTTAGGCAGGCCTGGACTTCTCGCCCT
TCCCCTTGCAGCTTCTGCTCTCCCAGCTAGGGACTGAGGAAAGCCCTGCTTCTAGATGCCATGTGCTGCTGCCTGGCACGATAGGTACCC
ATCTGTCCTTGGGGTTCCTGAGCCTGGAGAGCGGGCTTTGTGAGCACTGGTGCCTCACCTGCCTGGCTCAGCTCTGCAGCCACAATATAT
GCTTAATACCTATTTGTTAAATGATTGAAGACTTGACTGCCATTCAGTACAGAGAATTAGCCAGGTGAATAAACAGGATGTGTCATAGAG
GTTCTAGAATTGATCATGACCCTTTCTGTCTCATTCCTGACTTCTAATACCGTATATGCCAAATGGGGTTCTGCTGTGATTTAATTTCTT
AAGGACTGGGTTTATCAAAAGTCCCTCCTGATCTAATCCTTTCCTCTAGGAAGGCTTCTCCTTTCTTCATCTGTCCTAAGTGCATGGTCT
TCATCTCCTGGGTGGTCCAGACTAGGTGGCACTGGGCCTGCAGGCCTCTAGCTGCTCAAGGATGGCCCTGTCTGCATGCTTCCTTTCAAA
AGCTAGCATAGAAAGGAGGGCCCAAGGTGAGGAAATTTGTCCAAAGTCACCCAATGAGTCGCAGGAAGGGCTAGAATCTGGTTATCTGGA
CCGTCCTAGAGCACTTTCACAGTGACAGCCGGCTGGAATCAAGTTTTCATTTAGAAAAATGGCTAGAAGTTAGGGCATTGCCTGCAGCCA
CTGAAAAGCAGCTTTAGGAGCAGATGTCCACGTAATAGAAGGAGATGGGCTAGGGCCTGCCACGGAAGCCAGCAAGCGCGTGGGAGCTGG
GGGAGGAAAGGAGCAAAAGGCAAGAACAGGCAGTATGTCCGCGGTGCCCACAGTGCTGTGGGTACAAGCAAGGGGAAAAGAGCCCATGGT
GTGCAGAAAACCATGCGTCATGATTCTTATTTCCTGCTCGCAGCTTTGACTCTCTGCCTCATCTCTTCCTGGAAGTGTCTTGGAAGTTAG
GCGACTGCACAGGGAAAGGTTCGCTGCAGTGCTTGCAGGCCTGCACCCATTTATTCATCCGGTGGATATTTGCTGGGTGCCCGGCCTGGG
GATCCATGGTGAGCGAGGAAGGCATGGTATTGAAGTGGTATGCCTGCATGACCTTGGCGGGGGCGCATGGCATAGAGAGGACAGGCTTCA
GAACAGGCAGGCAAGGGCTGAAATCCTATCTCTGCCACCGAACAGCTAATGACCCCAGCAAGCAATTTCACATCCCCGAACTTTCCTGTT
TCCTCATGTGTCAAATGGGGATGATCTCGAGACGACTCTCCAGAGTAACCACGTGAAGCACCTAGCACAGGGGCTGACGCAAACAGCTGG
GCATCGGAGGAGCCTCCAGGGTTGTGACCTCCAGTGGCTTATTTTCCTTTTGGGATCTTCTCTCCTAGATCCTCCCCTTTAATTCCCTGT
GAAATTTACCACTTTCATATTGAATCGTTGGCACACAGGGCTAACTGCTTGTTCACCTGAAGGAAGCTACAGAGTTCAGGTTTCTTTTTT
CTTTCTTTCTTTCTTTTTTGCTTTTTTAAGATGATCTTGCTCCGTCACCCAGGCTGGAGTGCAGTGGCGTAATCATGGCTTCCTGCAGCC
TCAAACTCCTGGGCTCAATGAGTTCCTTGAGATCTTCCATCCTCAGCTTCCCAAGTAGCTAGTAGTAGTAGTGGCTTGCACCAACGCTCC
TGCCCTAATTTTCAATATTTTTTTGTAGAGATAGGATCTCACTGTGTTACCCAAGCTAGACTTGAACTCCTGGCCTCAAGCGATCCTTCC
GCCTTGGCCTCCCAAAGTGTTGGGATTACAGGCATTAGCTACCACACCTGGCCAAGGCCCAGGTTTCGACAGAAAGGGAGAGAAAACCTG
CCAGAGATGCCATTTCGGAGCCACTCTGCTTGGCAGGGACCTGTGTTCCCCTCATGCAGGTTCATCCTTAGAGGGCTGCGGTCTTATCTG
GTTGTGCAAAAGTCCCACAACCTTTCTGGATTGATAGTTTGTGGTGAAATAAACAATTTTAGTTTGTTTGGAGAATCTTTTGTATACAAA
ATACAAATAAAACCTAAATCAAAGAAACAGAGCATGTCCGGAGAAGTCTGCCAACCCTTCTCCAGGCCATGGGGCTTCCCAAGCCAGGCC
TGTACTCCTCATGTAGATTCCACACCCCGCCTTGATGTCTTTGGCTTTCACACTAGTGACTATAGCCTGGTGGGACGGGGTCTAGGGGCC
ACAGTCCTGGTCCTGCGCAGGTGGCCCTGGAGAGAAGCCTTGGAGAACTTGGAGAAGCCCACGCGGCTGGCAGCATCATGGTGAGAGGCT
GACACCTTGTGGCTGGCTGGCAGCATACGTCCTTCCTCCCCTAGGTCAGCTAGACGGCCAAAGCAGGGATCTGCAAGCTCCTTCTGTGGC
GGGCCAAAAAGTGAACATTCAGTGTGTCTGTTGCAGCTACTGTCATAGCACTGAGGCACCCCTAGACAGTACAGAAACAAGCAGGTGTGG
CCATGTTCCAGTGAAACCTTATGAATACTGAAATCTGAATCCATAATTTTCATGTATCACAAAGTAGTAATATTCTTTTAATATGCAAAA
ACCGGCCAGGTGCGGTGGCTCATGCCTGTGACCTCAGCACTTTGGGAGGCCGAGGTGGGTGGATCACCTGAGGTCAGGAGTTCGAAACCA
GCCTGGCCAACGTGGTGAAACCCTGTCTCTATTAAAAATACAAAAATTAGCCTGGTGTGGTGGCACATGCCTGTAATCCCAGCTACTCGG
GAGGCTGAGGCGTAGGAATTGCTTAAACCTGGGAGGCGGAGGTTGCAGTGAGCTGAGATCATGCCACTGCACTTCAGCCTGGGCAACAGA
GCTAGACTCCATCTCAAAAACAAACAAACAAAAAAACAAAAGCAAAAACCAGTCTTAGCTCACAGGCTGTGCCAAAACAGGCAGTGGGCT
GGATTTGGTCCTCAAGCCTGGGCTTGCTGACCTCTGGCCTAGGACACCTCTCCTTTATGCCTCCGCTCCCAACACGGACTCTCAACTCTC
ATGTTTACCTTGTCATTGTTCTGTCAAGAGGAATTCACTAGTCTCACTCCTCCAACCAGACCGCTGCCACTAAGGCTTCTTCTGAACAGA
AATTCTGGATTTGTTCTCACCCATTTCATAAATGTACATAAGCACCCATCAGGTGCCAAGCCCTGTGCTGAGATGCCTGCAGAGCCCAGA
GTTTTCACCAACTTTTTTTTTAAGAGATGGGGGTCTCTGTTGCCAGGTTGGAGTGCAATGACATAATCATAACTCACCGCAACCTCAAAC
TCCTAGGTTCAGGTGATCCTCCCGCCTCAGCCTCCCAAGTAGCTGGGACTACAGGCATGCACCACCCTGCCCAGCTAATTAAAAAAAAAA
CTTTAGGGATGGGGTCTTGCTATGTTGTCTAGGCTGGTCTCTAACTCCTGGGCTCAAGTGATCCTCCCACCTCAGCCTCCCAAGTAGCTG
GGCTTACAGATGTGAGCCACTGCACCTGCTCAACATTTAATTTTTTCATTCATTCATTCGTTCATTCATTTGTTCAAACGAACTTATTGA
GAACTTACTGTGTTCCAGGCACTGTGATAAGATAGACCTGGCCTTTACCTTCAAATGTTCAGAACATGGTTAGGAAGATGGATACTGGGA
GGCAAGTGTTCTGATGGGAAAGCACAGCATGTAAAGAAGCCCAGAGGAGGCACTTAACCTGGGGGAGAAGAACAGGGTAGGCTTCCTGGA
GGAGGAGGTAATCTCTGAGCCGATACCTGAGGAGTGAATGGAGGAGGGGACAATGAGGCAAGGCATTCCAGGGAAAGGTCCAGAGCCTAG
ACAGAACTCTTTTAGGAGAATTATGAGAATCACAATTATCGAGGACACAGTGAAGACTCAGATAACTCAAATATAGGTTTTGCCCGCAAA
GCCTTCCTGTCTGGTGGGTGAGACAGTCTACAGCAAGCTGCTCCAAGGATATGGAGAAAAAAGTTTTTCCTCTGGCCTTGTAGGATTGGT
TATTACTGAGCCTGGAGTACGCAAAGGCCAGCGAGTGCTCCTAAGGCAGGGAGGGGGCTGCCTTCACTATGGGTGCTCAGGAAATCTGCC
AGGGGAAGGGAGATGTGGGCCTGCCTCGGCTGCAGAAACCCCTCAGAGGAGGAGGAGGGGCTTGAACTGAGCTTTGAAGAAAGTGTAGAC
TTGGGGACAGGCAGAGGAAGAGGGGGCATCATAGGCAGCAGAAACCACATGGACAAACTCTCTGCCGGAGAATGGGCATGGCCGGGCTGA
GGGGTCCCTGGACAGGAACCAGCCTTCCCTATGCACCTGCACCCGTGAGTCTCACAACAGCCCCAACAGGCAAGTGTTATTTTCCTCAAT
TCTACCAATTAAAAACTGACCTTGGGCAACTGCTTAACCTATCTCTGCCTTACTTTCTTCATCTGTATCTACCTCAGAAAGTTACTATGA
GGACTGAATAAGCTCATACATATACAATGCTTGGAGCAGAGGCTGGTACTAGAGCTGGCTTCATGGGCATGAAACCTGTGAACACAGAAC
CCCATGCTTTCATTTTCCACTTAGTCCTGCCTGGCATAGTATGCAGTTTTTTTAATTTGAGATGGAGTCTCCCTTTGTTGCCCAGGCTTG
AGTGCAGTGGCGCGATCTCAGCTCACTGCAACCTCCACCTCCCAGGTTGAAGCAGTTCTCCTGCCTCAGCCTCCTGAGTAGCTGGGATTA
CAGGTGCGCGCCACCATACCCAGCTAATTTTTGTATTTTTAGTAGAGATGAGGTTTTGCCATTTTGGCCAGCCTGGTCTTGAACCTCTGA
CTTCCATGATCCACCTGCCTCTGCCTCCCAAAGTGCTGGGAGGATTACAGGCATGAACCACTACGCCTGGCCTGGTATGTGGGTTAAAAT
GTTAGGTTTTATCATTATCTTAGGTGGAGAATAACAAATCCGATTCAATATATTCATTTTAGAAACGAGGAAACTGAAGCTTAGATAGTT
TGTGTGACTTGCAAAAAGTCACGCAGCAAACAAGCTGCAGAATGAAGGGTGGAGATGGAGAGATAGAATTCTCATCTTAGAGGTGAAAGT
AGGATAATGACCCAGCTGAGCTTGCTGAGTCCTGCGAGCGTCGCACGCCCCCAGAGACAACATAAGGAGAGAAGTGCAGACAGATTCCTT
TGAAGGAGCTTAGAGAAAGAGATGGTAGGGAAAAGAGCATGAACAGTTGTAGAGGTAGGAGGAAAGCTGGCTATTTGGGGAAGCAAAGAA
AAGATTCTCAGAGTAAAACGTATTGGTGAAGCCATGGAAACAAGGACTGAGAAAGTCTCTTGGATCTTGGCCACAAAAAGGTTATAGATG
AGCTTAGAGAAATGAATTTCAGTAGAGTTAGGGCTAGAAGCCAGGTTCAGAGAGAGAAAACGAGAGAGCATTCCTGGTGGTGGAGATGGC
CGCAGGCCATTATTTAAAAAGCTAGGATAAGAAAATAGAGAAGAAAGGGAAGGAAGCTATTTGAAGGGAGTGGGAGAAAAGCCAGATCTC
AGTTGGGACGTGGAGGAAGGACCACCAGAGGCAGTAATTTAGCCGGAAAGAGGTGTATTTCTTTCCTTGAGTTTATAGGGGGTAAAGAGG
ATGGGGCTGAGATACTAAAGACTACGAGGACAACTGTTCATTGAGGGCTGGTCATCTCCCCAGCTGCACTGTGGGGTTCCCAAGTCAGAC
ATCCCAGAGGCAATATAGCAGCGTGGACAAGAGCTTACTCGTTGGAGTCAGACCGCCTAGGTTCAACGATGGGTTAGTTAGCCCTTCAGT
GCCTCCATTTTCCTATCTAGAAAATGTGGATAACAATGGTTGTTGTGAAGATTAACAGCCATAATCCACGTAAAGCCCTCAGTACAGTGT
ATGACACACAGCAAGTGTCCACCAAAGGGTAGTTATTATTAACCATAATCCTGGTTCTCTTGTGAGCTGCCTCCTGTGTGTCTAGCATTG
GCCAGCACACATGAGGGGGTCCAGTGTTTGCTGCTTAACTAAGTAGCTTCTCAGGAAGTGTGGTCATAAAAAATGATAGGTGATTTAGAA
GGTGAGACAGACACAAGGGATGTGTTGCACAGTAAATGCTCCCAGACATGCAATAAATGCTTATAAGCATGCCCTCTGTAATCAGCCCTC
TTTAGAGAGTTTCCCTGCCTCATTGCTCTTGGTCTTTGGCAATGGCTACACCCACTGCCCAAGCAAGCAGTATCAGCTGTCAGCTGTCCC
CTTGTCTTTTGGATCAGATTCCTTTACAGGGATCTTCCCATTGTTATAAGCTTCAAGAATTGGAGAATGCTTAATGAACACTTCCAAATT
CTTCATAGCTATGAGGGGCCAGTGCAAAGGGCGGAAGGAGTTCTTCTGTGTCACAGAAATTAGAGCTGGAGCAGATCCAGCTTGCTATCC
CCCCTTCCCCCAGCTTGTGGGTTATTGCAGAATTGTTCACAAAAATTCCCATTGCCTTGGAATTTGTCCAAGCCGAGGGCAGGGATCACA
ACACAACCTCTCAAGGGAAAAAAGGAAGGCCTGTTGCTTGAGATGGCTCAGAGCACTTTTGGTAGCCAGCCAAGGCAGCTATCACTCATG
AAATCTGCCTTCCCCTCCAGCAAAAAGCCAACTGTATAGAACACCACATATAGAGCGCTAAGAATAGCACAGCGCTCCAAGAACATAGTG
CACTTGGCCTGCATACAAGTGTGCAGGGCTTAACGAGTCTTTTTACTCTGAAAGCTGGGTGGGTTGGAACAAACAAACAGAAAAATATTT
TCCCCAAGTAGCATGCAGAGAGGAAATGAGAGCAAGCACAAGAGAGCACCCTGGCATAGCATTCTCTGACCTGGGCTGCCTTTTCAGGGT
ATGAGTTGATTCCGCAGGCACCAAGGCATGCCTGTAAGCCCTACAGGGCAGACGCCCTCACCCCAATCATTGGCTTAACATTCACACCAG
GCTGAGTAAGCCCCAAAAGTCCTGCCATTGGCTCTGACAGGAATTGAAACCCATCTTCTCCACAATAAATATTTGATTGACAGATTGGCT
TCCTTCCTATAAGTATAGAAAGCGAGGGCAGGTTCCATCCAAAGCCGCAGTTCTGGGTGATGAGAGCTCTGAGAGCCCAGAAAAGACCCT
GAACCACATCCCACTGTTTGTTGGAAGAAGAAACTCATTTGTGGGTCTGTTCATAAAAGAGTCTGGGAAGATAGTCTCCTTAACAGTGTC
TGGATGTAACAGACTATGGGCGGCTTTTACTTTATAACTTTCTATATTGTCTGAAATACAGAATATTAAATATTGAGTTAATATTATATT
TACTCAATGTTACTTTTTTTTTTTTTGAGACAGGGTCTTGCTCTATTGCCCAGGCTGGAGTGCAGTGGTGTGGCTCACTGCAGCCTTGAA
CTCCCAGGCTCAAGCAATCCTCCCACCTCAGCATCCCAAGTAGCTGGGACTGTAGGCGCAGGCCACCATGCGCAACTATTTATTTTCTTT
CTTTTTGTAGAAATGGGCTCTGCCTGTGTTGCTCTAGCTAGTCTCAAGCTCCTGGCCTCAAGCAATCCTTCCGCCTTGGCCTCTCAAATT
GCTGGGATTACAAGCATAAGCCAATGTGCCTGGCCTCAATGTTACTTTTATGATCAGAAAAACGGCCATCTTATTTGGAAATTATTTTCC
TATTCTCAAGTGGGCAAATAGGAGAAGGTTTCAGGCATTTGTTTTGTCTCTGGGAGGGAAGGCACAATGAGGTGGAGTGGACAAATTGCT
GAGGCCTTTATGGACAAAGATTCTAAGAAGAACAGGCTTTGGCCATCTCTGGATATTCCCATTCTGCTCCCTGCCACCAGAGAGCAAATG
TCGTAGGTCACCACACATCACCAGTCTCTTGCCTAGCTAACCGTAACTCATTCTTTAGTTCTCCTTGAAGGTGTCACTTCTTCCAGGAAG
CCATTTCTGTCCCTCCCGAGATGGAGTCCCATGTCCCTACCATTTGCTTCCAGGGCACCTTCTCACAGCACTGCATCATGGTTATCTGCT
TATCTGCTGGACACCCCTACTCGACTGAGGTCCTTGAAGGAAGAGAGAGTGTATCACTCATCTGCATAGCCTTTGTAACTTAGTAAAAGT
GCCTGACATGCTCACTAAACATTTACTGAGTAATTATTTATTTGGGGGCCTTTTACGATCAGAACAATGTGAAGGACACAAAGATGAAAA
AGAAACCATCTGCTTCAAGGTACTTACAACTGAAATGTATCAAACAATTACCCAGAAAGTCAAGCACCAACTTAAGTGCTAAAATAGGGG
TCCAAGCAACCAACTTTGAAGATTAGGAAGGTTTTAGATTCTGAATGTTTCTCATTCATTGTGTTTTTGAGTTCAGAATCCCCATACTGG
AAGGCTAATATGGGGTATGTGCATACAATTTTAAGGACTCACGTTCTTACAACCTATATTAGAATTTGACGCACGATCTTTCTTCTGTCC
TTCTTGCAGTTGCCCTAGGAATACATGCCACTTACTCTTAATTGACGTTTATGAAATACCTTGGCTTCATTTGCTGAAAGGCTCTAAGTG
TTGAGCATTGTTACTATGTTACAATGGTTGTTTTATTATTAAAGCAGTGCCAAGGAGGTTACACAACAGCTTGGATCAGGAAGTGAAACA
AGGGCGGTGATCCCACTGAAGCTACAGGGGATGGGGATTTGGGACGGTAAAATGTTAATTACCCAAGATGGAATGTGGGCTAGAGTCCAG
CGTTGTGCTCCTGGAGATCATTTCGGTCGCAAAAGCTCACTGGCAATGGGTCCTAAGCGTCCTGCCCTCCTCTGGCTGAAATGTTGGATT
CACTTCGATGAATGCTGCTATAGGGAAAGAACCCAGTGGCCACCAGCCAGGAGCACACGTCTTGCTCAGCATCAACTATCCTGGAAGATT

>78504_78504_1_RTCB-FAM83F_RTCB_chr22_32802649_ENST00000216038_FAM83F_chr22_40425520_ENST00000333407_length(amino acids)=212AA_BP=
MHQRSCPNFQYFFVEIGSHCVTQARLELLASSDPSALASQSVGITGISYHTWPRPRFRQKGRENLPEMPFRSHSAWQGPVFPSCRFILRG
LRSYLVVQKSHNLSGLIVCGEINNFSLFGESFVYKIQIKPKSKKQSMSGEVCQPFSRPWGFPSQACTPHVDSTPRLDVFGFHTSDYSLVG

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Top

Fusion Gene PPI Analysis for RTCB-FAM83F

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for RTCB-FAM83F

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for RTCB-FAM83F

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source