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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ATP2B1-EXOC4 (FusionGDB2 ID:7851)

Fusion Gene Summary for ATP2B1-EXOC4

check button Fusion gene summary
Fusion gene informationFusion gene name: ATP2B1-EXOC4
Fusion gene ID: 7851
HgeneTgene
Gene symbol

ATP2B1

EXOC4

Gene ID

490

60412

Gene nameATPase plasma membrane Ca2+ transporting 1exocyst complex component 4
SynonymsPMCA1|PMCA1kbSEC8|SEC8L1|Sec8p
Cytomap

12q21.33

7q33

Type of geneprotein-codingprotein-coding
Descriptionplasma membrane calcium-transporting ATPase 1ATPase, Ca++ transporting, plasma membrane 1plasma membrane calcium pumpexocyst complex component 4SEC8-like 1exocyst complex component Sec8
Modification date2020032220200320
UniProtAcc

P20020

Q96A65

Ensembl transtripts involved in fusion geneENST00000261173, ENST00000348959, 
ENST00000359142, ENST00000428670, 
ENST00000393164, 		ENST00000393161, 
ENST00000460346, ENST00000541309, 
ENST00000545148, ENST00000253861, 
ENST00000539845, 
Fusion gene scores* DoF score15 X 12 X 6=108035 X 25 X 10=8750
# samples 1339
** MAII scorelog2(13/1080*10)=-3.05444778402238
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(39/8750*10)=-4.48773698785744
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ATP2B1 [Title/Abstract] AND EXOC4 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointATP2B1(90049456)-EXOC4(133749044), # samples:2
Anticipated loss of major functional domain due to fusion event.ATP2B1-EXOC4 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneATP2B1

GO:0051480

regulation of cytosolic calcium ion concentration

18029012

HgeneATP2B1

GO:1990034

calcium ion export across plasma membrane

18029012


check buttonFusion gene breakpoints across ATP2B1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across EXOC4 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SARCTCGA-DX-A3LS-01AATP2B1chr12

90049456

-EXOC4chr7

133749044

+


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Fusion Gene ORF analysis for ATP2B1-EXOC4

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000261173ENST00000393161ATP2B1chr12

90049456

-EXOC4chr7

133749044

+
5CDS-intronENST00000261173ENST00000460346ATP2B1chr12

90049456

-EXOC4chr7

133749044

+
5CDS-intronENST00000261173ENST00000541309ATP2B1chr12

90049456

-EXOC4chr7

133749044

+
5CDS-intronENST00000261173ENST00000545148ATP2B1chr12

90049456

-EXOC4chr7

133749044

+
5CDS-intronENST00000348959ENST00000393161ATP2B1chr12

90049456

-EXOC4chr7

133749044

+
5CDS-intronENST00000348959ENST00000460346ATP2B1chr12

90049456

-EXOC4chr7

133749044

+
5CDS-intronENST00000348959ENST00000541309ATP2B1chr12

90049456

-EXOC4chr7

133749044

+
5CDS-intronENST00000348959ENST00000545148ATP2B1chr12

90049456

-EXOC4chr7

133749044

+
5CDS-intronENST00000359142ENST00000393161ATP2B1chr12

90049456

-EXOC4chr7

133749044

+
5CDS-intronENST00000359142ENST00000460346ATP2B1chr12

90049456

-EXOC4chr7

133749044

+
5CDS-intronENST00000359142ENST00000541309ATP2B1chr12

90049456

-EXOC4chr7

133749044

+
5CDS-intronENST00000359142ENST00000545148ATP2B1chr12

90049456

-EXOC4chr7

133749044

+
5CDS-intronENST00000428670ENST00000393161ATP2B1chr12

90049456

-EXOC4chr7

133749044

+
5CDS-intronENST00000428670ENST00000460346ATP2B1chr12

90049456

-EXOC4chr7

133749044

+
5CDS-intronENST00000428670ENST00000541309ATP2B1chr12

90049456

-EXOC4chr7

133749044

+
5CDS-intronENST00000428670ENST00000545148ATP2B1chr12

90049456

-EXOC4chr7

133749044

+
Frame-shiftENST00000261173ENST00000253861ATP2B1chr12

90049456

-EXOC4chr7

133749044

+
Frame-shiftENST00000261173ENST00000539845ATP2B1chr12

90049456

-EXOC4chr7

133749044

+
Frame-shiftENST00000348959ENST00000253861ATP2B1chr12

90049456

-EXOC4chr7

133749044

+
Frame-shiftENST00000348959ENST00000539845ATP2B1chr12

90049456

-EXOC4chr7

133749044

+
Frame-shiftENST00000359142ENST00000253861ATP2B1chr12

90049456

-EXOC4chr7

133749044

+
Frame-shiftENST00000359142ENST00000539845ATP2B1chr12

90049456

-EXOC4chr7

133749044

+
Frame-shiftENST00000428670ENST00000253861ATP2B1chr12

90049456

-EXOC4chr7

133749044

+
In-frameENST00000428670ENST00000539845ATP2B1chr12

90049456

-EXOC4chr7

133749044

+
intron-3CDSENST00000393164ENST00000253861ATP2B1chr12

90049456

-EXOC4chr7

133749044

+
intron-3CDSENST00000393164ENST00000539845ATP2B1chr12

90049456

-EXOC4chr7

133749044

+
intron-intronENST00000393164ENST00000393161ATP2B1chr12

90049456

-EXOC4chr7

133749044

+
intron-intronENST00000393164ENST00000460346ATP2B1chr12

90049456

-EXOC4chr7

133749044

+
intron-intronENST00000393164ENST00000541309ATP2B1chr12

90049456

-EXOC4chr7

133749044

+
intron-intronENST00000393164ENST00000545148ATP2B1chr12

90049456

-EXOC4chr7

133749044

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000428670ATP2B1chr1290049456-ENST00000539845EXOC4chr7133749044+96266590562493

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000428670ENST00000539845ATP2B1chr1290049456-EXOC4chr7133749044+0.102259310.8977407

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Fusion Genomic Features for ATP2B1-EXOC4


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
ATP2B1chr1290049455-EXOC4chr7133749043+2.59E-070.99999976
ATP2B1chr1290049455-EXOC4chr7133749043+2.59E-070.99999976

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for ATP2B1-EXOC4


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:90049456/chr7:133749044)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ATP2B1

P20020

EXOC4

Q96A65

FUNCTION: Catalyzes the hydrolysis of ATP coupled with the transport of calcium from the cytoplasm to the extracellular space thereby maintaining intracellular calcium homeostasis. Plays a role in blood pressure regulation through regulation of intracellular calcium concentration and nitric oxide production leading to regulation of vascular smooth muscle cells vasoconstriction. Positively regulates bone mineralization through absorption of calcium from the intestine. Plays dual roles in osteoclast differentiation and survival by regulating RANKL-induced calcium oscillations in preosteoclasts and mediating calcium extrusion in mature osteoclasts (By similarity). Regulates insulin sensitivity through calcium/calmodulin signaling pathway by regulating AKT1 activation and NOS3 activation in endothelial cells (PubMed:29104511). {ECO:0000250|UniProtKB:G5E829, ECO:0000269|PubMed:29104511}.FUNCTION: Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneEXOC4chr12:90049456chr7:133749044ENST0000039316101032_1140474.0Coiled coilOntology_term=ECO:0000255

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneATP2B1chr12:90049456chr7:133749044ENST00000261173-120296_299691221.0Compositional biasNote=Poly-Glu
HgeneATP2B1chr12:90049456chr7:133749044ENST00000348959-119296_299691185.0Compositional biasNote=Poly-Glu
HgeneATP2B1chr12:90049456chr7:133749044ENST00000359142-121296_299691177.0Compositional biasNote=Poly-Glu
HgeneATP2B1chr12:90049456chr7:133749044ENST00000428670-221296_299691221.0Compositional biasNote=Poly-Glu
HgeneATP2B1chr12:90049456chr7:133749044ENST00000261173-1201100_1117691221.0RegionCalmodulin-binding subdomain A
HgeneATP2B1chr12:90049456chr7:133749044ENST00000261173-1201118_1220691221.0RegionRequired for basolateral membrane targeting
HgeneATP2B1chr12:90049456chr7:133749044ENST00000348959-1191100_1117691185.0RegionCalmodulin-binding subdomain A
HgeneATP2B1chr12:90049456chr7:133749044ENST00000348959-1191118_1220691185.0RegionRequired for basolateral membrane targeting
HgeneATP2B1chr12:90049456chr7:133749044ENST00000359142-1211100_1117691177.0RegionCalmodulin-binding subdomain A
HgeneATP2B1chr12:90049456chr7:133749044ENST00000359142-1211118_1220691177.0RegionRequired for basolateral membrane targeting
HgeneATP2B1chr12:90049456chr7:133749044ENST00000428670-2211100_1117691221.0RegionCalmodulin-binding subdomain A
HgeneATP2B1chr12:90049456chr7:133749044ENST00000428670-2211118_1220691221.0RegionRequired for basolateral membrane targeting
HgeneATP2B1chr12:90049456chr7:133749044ENST00000261173-1201028_1039691221.0Topological domainExtracellular
HgeneATP2B1chr12:90049456chr7:133749044ENST00000261173-1201061_1220691221.0Topological domainCytoplasmic
HgeneATP2B1chr12:90049456chr7:133749044ENST00000261173-120127_154691221.0Topological domainExtracellular
HgeneATP2B1chr12:90049456chr7:133749044ENST00000261173-120176_366691221.0Topological domainCytoplasmic
HgeneATP2B1chr12:90049456chr7:133749044ENST00000261173-1202_105691221.0Topological domainCytoplasmic
HgeneATP2B1chr12:90049456chr7:133749044ENST00000261173-120387_418691221.0Topological domainExtracellular
HgeneATP2B1chr12:90049456chr7:133749044ENST00000261173-120440_855691221.0Topological domainCytoplasmic
HgeneATP2B1chr12:90049456chr7:133749044ENST00000261173-120877_882691221.0Topological domainExtracellular
HgeneATP2B1chr12:90049456chr7:133749044ENST00000261173-120904_927691221.0Topological domainCytoplasmic
HgeneATP2B1chr12:90049456chr7:133749044ENST00000261173-120949_971691221.0Topological domainExtracellular
HgeneATP2B1chr12:90049456chr7:133749044ENST00000261173-120992_1005691221.0Topological domainCytoplasmic
HgeneATP2B1chr12:90049456chr7:133749044ENST00000348959-1191028_1039691185.0Topological domainExtracellular
HgeneATP2B1chr12:90049456chr7:133749044ENST00000348959-1191061_1220691185.0Topological domainCytoplasmic
HgeneATP2B1chr12:90049456chr7:133749044ENST00000348959-119127_154691185.0Topological domainExtracellular
HgeneATP2B1chr12:90049456chr7:133749044ENST00000348959-119176_366691185.0Topological domainCytoplasmic
HgeneATP2B1chr12:90049456chr7:133749044ENST00000348959-1192_105691185.0Topological domainCytoplasmic
HgeneATP2B1chr12:90049456chr7:133749044ENST00000348959-119387_418691185.0Topological domainExtracellular
HgeneATP2B1chr12:90049456chr7:133749044ENST00000348959-119440_855691185.0Topological domainCytoplasmic
HgeneATP2B1chr12:90049456chr7:133749044ENST00000348959-119877_882691185.0Topological domainExtracellular
HgeneATP2B1chr12:90049456chr7:133749044ENST00000348959-119904_927691185.0Topological domainCytoplasmic
HgeneATP2B1chr12:90049456chr7:133749044ENST00000348959-119949_971691185.0Topological domainExtracellular
HgeneATP2B1chr12:90049456chr7:133749044ENST00000348959-119992_1005691185.0Topological domainCytoplasmic
HgeneATP2B1chr12:90049456chr7:133749044ENST00000359142-1211028_1039691177.0Topological domainExtracellular
HgeneATP2B1chr12:90049456chr7:133749044ENST00000359142-1211061_1220691177.0Topological domainCytoplasmic
HgeneATP2B1chr12:90049456chr7:133749044ENST00000359142-121127_154691177.0Topological domainExtracellular
HgeneATP2B1chr12:90049456chr7:133749044ENST00000359142-121176_366691177.0Topological domainCytoplasmic
HgeneATP2B1chr12:90049456chr7:133749044ENST00000359142-1212_105691177.0Topological domainCytoplasmic
HgeneATP2B1chr12:90049456chr7:133749044ENST00000359142-121387_418691177.0Topological domainExtracellular
HgeneATP2B1chr12:90049456chr7:133749044ENST00000359142-121440_855691177.0Topological domainCytoplasmic
HgeneATP2B1chr12:90049456chr7:133749044ENST00000359142-121877_882691177.0Topological domainExtracellular
HgeneATP2B1chr12:90049456chr7:133749044ENST00000359142-121904_927691177.0Topological domainCytoplasmic
HgeneATP2B1chr12:90049456chr7:133749044ENST00000359142-121949_971691177.0Topological domainExtracellular
HgeneATP2B1chr12:90049456chr7:133749044ENST00000359142-121992_1005691177.0Topological domainCytoplasmic
HgeneATP2B1chr12:90049456chr7:133749044ENST00000428670-2211028_1039691221.0Topological domainExtracellular
HgeneATP2B1chr12:90049456chr7:133749044ENST00000428670-2211061_1220691221.0Topological domainCytoplasmic
HgeneATP2B1chr12:90049456chr7:133749044ENST00000428670-221127_154691221.0Topological domainExtracellular
HgeneATP2B1chr12:90049456chr7:133749044ENST00000428670-221176_366691221.0Topological domainCytoplasmic
HgeneATP2B1chr12:90049456chr7:133749044ENST00000428670-2212_105691221.0Topological domainCytoplasmic
HgeneATP2B1chr12:90049456chr7:133749044ENST00000428670-221387_418691221.0Topological domainExtracellular
HgeneATP2B1chr12:90049456chr7:133749044ENST00000428670-221440_855691221.0Topological domainCytoplasmic
HgeneATP2B1chr12:90049456chr7:133749044ENST00000428670-221877_882691221.0Topological domainExtracellular
HgeneATP2B1chr12:90049456chr7:133749044ENST00000428670-221904_927691221.0Topological domainCytoplasmic
HgeneATP2B1chr12:90049456chr7:133749044ENST00000428670-221949_971691221.0Topological domainExtracellular
HgeneATP2B1chr12:90049456chr7:133749044ENST00000428670-221992_1005691221.0Topological domainCytoplasmic
HgeneATP2B1chr12:90049456chr7:133749044ENST00000261173-1201006_1027691221.0TransmembraneHelical
HgeneATP2B1chr12:90049456chr7:133749044ENST00000261173-1201040_1060691221.0TransmembraneHelical
HgeneATP2B1chr12:90049456chr7:133749044ENST00000261173-120106_126691221.0TransmembraneHelical
HgeneATP2B1chr12:90049456chr7:133749044ENST00000261173-120155_175691221.0TransmembraneHelical
HgeneATP2B1chr12:90049456chr7:133749044ENST00000261173-120367_386691221.0TransmembraneHelical
HgeneATP2B1chr12:90049456chr7:133749044ENST00000261173-120419_439691221.0TransmembraneHelical
HgeneATP2B1chr12:90049456chr7:133749044ENST00000261173-120856_876691221.0TransmembraneHelical
HgeneATP2B1chr12:90049456chr7:133749044ENST00000261173-120883_903691221.0TransmembraneHelical
HgeneATP2B1chr12:90049456chr7:133749044ENST00000261173-120928_948691221.0TransmembraneHelical
HgeneATP2B1chr12:90049456chr7:133749044ENST00000261173-120972_991691221.0TransmembraneHelical
HgeneATP2B1chr12:90049456chr7:133749044ENST00000348959-1191006_1027691185.0TransmembraneHelical
HgeneATP2B1chr12:90049456chr7:133749044ENST00000348959-1191040_1060691185.0TransmembraneHelical
HgeneATP2B1chr12:90049456chr7:133749044ENST00000348959-119106_126691185.0TransmembraneHelical
HgeneATP2B1chr12:90049456chr7:133749044ENST00000348959-119155_175691185.0TransmembraneHelical
HgeneATP2B1chr12:90049456chr7:133749044ENST00000348959-119367_386691185.0TransmembraneHelical
HgeneATP2B1chr12:90049456chr7:133749044ENST00000348959-119419_439691185.0TransmembraneHelical
HgeneATP2B1chr12:90049456chr7:133749044ENST00000348959-119856_876691185.0TransmembraneHelical
HgeneATP2B1chr12:90049456chr7:133749044ENST00000348959-119883_903691185.0TransmembraneHelical
HgeneATP2B1chr12:90049456chr7:133749044ENST00000348959-119928_948691185.0TransmembraneHelical
HgeneATP2B1chr12:90049456chr7:133749044ENST00000348959-119972_991691185.0TransmembraneHelical
HgeneATP2B1chr12:90049456chr7:133749044ENST00000359142-1211006_1027691177.0TransmembraneHelical
HgeneATP2B1chr12:90049456chr7:133749044ENST00000359142-1211040_1060691177.0TransmembraneHelical
HgeneATP2B1chr12:90049456chr7:133749044ENST00000359142-121106_126691177.0TransmembraneHelical
HgeneATP2B1chr12:90049456chr7:133749044ENST00000359142-121155_175691177.0TransmembraneHelical
HgeneATP2B1chr12:90049456chr7:133749044ENST00000359142-121367_386691177.0TransmembraneHelical
HgeneATP2B1chr12:90049456chr7:133749044ENST00000359142-121419_439691177.0TransmembraneHelical
HgeneATP2B1chr12:90049456chr7:133749044ENST00000359142-121856_876691177.0TransmembraneHelical
HgeneATP2B1chr12:90049456chr7:133749044ENST00000359142-121883_903691177.0TransmembraneHelical
HgeneATP2B1chr12:90049456chr7:133749044ENST00000359142-121928_948691177.0TransmembraneHelical
HgeneATP2B1chr12:90049456chr7:133749044ENST00000359142-121972_991691177.0TransmembraneHelical
HgeneATP2B1chr12:90049456chr7:133749044ENST00000428670-2211006_1027691221.0TransmembraneHelical
HgeneATP2B1chr12:90049456chr7:133749044ENST00000428670-2211040_1060691221.0TransmembraneHelical
HgeneATP2B1chr12:90049456chr7:133749044ENST00000428670-221106_126691221.0TransmembraneHelical
HgeneATP2B1chr12:90049456chr7:133749044ENST00000428670-221155_175691221.0TransmembraneHelical
HgeneATP2B1chr12:90049456chr7:133749044ENST00000428670-221367_386691221.0TransmembraneHelical
HgeneATP2B1chr12:90049456chr7:133749044ENST00000428670-221419_439691221.0TransmembraneHelical
HgeneATP2B1chr12:90049456chr7:133749044ENST00000428670-221856_876691221.0TransmembraneHelical
HgeneATP2B1chr12:90049456chr7:133749044ENST00000428670-221883_903691221.0TransmembraneHelical
HgeneATP2B1chr12:90049456chr7:133749044ENST00000428670-221928_948691221.0TransmembraneHelical
HgeneATP2B1chr12:90049456chr7:133749044ENST00000428670-221972_991691221.0TransmembraneHelical
TgeneEXOC4chr12:90049456chr7:133749044ENST00000253861161832_114895975.0Coiled coilOntology_term=ECO:0000255


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Fusion Gene Sequence for ATP2B1-EXOC4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>7851_7851_1_ATP2B1-EXOC4_ATP2B1_chr12_90049456_ENST00000428670_EXOC4_chr7_133749044_ENST00000539845_length(transcript)=962nt_BP=665nt
AGCGTGAGTAGGGAGCCCCGGCTGGTGGACGCCGAGCCTCTCGGCTCCTTGGCCGCCCCATCCCCGAGGTGCAGCTGCACCTCCGCGTGG
CGCCCCGAGCCCTGCGAGCCGGCTGCGGACGCGCTGAGGACGGAGCCCCCATCCTCTGCGTTTCCCGCTGCCCCTTAACGCCCCGCGACC
CTCCCGCAGCCTGCCTTTCCTTCCCCCTCGGAAAATGGTTCCCACTGCCGGGCGAGATGTGTATATCTCATGATTGATATGGAGAAACTA
GTCATGGGCCAAAGGTCAAGATACTTCTCTGGGAAATGTTGCTGCTGATGCTGCTTTACAAAGTCATACAATGAGTGTTTGGTTTAAGAA
AGATTTTCATACTTAAAAGATTTTCATCTTGGAAATACATCAAGTGAAAATTAAATTCTTTTGGGAAACATTTTCCTTCTGATATATTAT
ACTTGTAATGGGCGACATGGCAAACAACTCAGTTGCTTACAGTGGTGTGAAAAACTCTTTGAAGGAAGCTAATCATGATGGAGACTTTGG
AATTACGCTCGCAGAGCTGCGGGCTCTCATGGAGCTCAGGTCCACAGATGCATTACGAAAAATACAGGAAAGCTATGGAGATGTCTATGG
AATTTGCACCAAATTGAAAACATCTCCCAATGAAGGCAGTACTACGAGATGCTTTACAACACAGCTGACGAGCTCCTGAACCTGGTGGTG
GACCAGGGTGTGAAGTACACGGAGCTGGAGTACATCCACGCTCTGACCCTGCTGCACCGCAGCCAGACTGGGGTGGGGGAACTGACCACC
CAGAACACGAGGCTGCAGAGGCTCAAAGAGATCATCTGCGAGCAGGCTGCCATCAAGCAAGCCACCAAGGACAAGAAGATAACTACCGTT

>7851_7851_1_ATP2B1-EXOC4_ATP2B1_chr12_90049456_ENST00000428670_EXOC4_chr7_133749044_ENST00000539845_length(amino acids)=93AA_BP=1
MLNGSYLLVLGGLLDGSLLADDLFEPLQPRVLGGQFPHPSLAAVQQGQSVDVLQLRVLHTLVHHQVQELVSCVVKHLVVLPSLGDVFNLV

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Fusion Gene PPI Analysis for ATP2B1-EXOC4


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ATP2B1-EXOC4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ATP2B1-EXOC4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource