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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ATP2B1-FYN (FusionGDB2 ID:7852)

Fusion Gene Summary for ATP2B1-FYN

check button Fusion gene summary
Fusion gene informationFusion gene name: ATP2B1-FYN
Fusion gene ID: 7852
HgeneTgene
Gene symbol

ATP2B1

FYN

Gene ID

490

2534

Gene nameATPase plasma membrane Ca2+ transporting 1FYN proto-oncogene, Src family tyrosine kinase
SynonymsPMCA1|PMCA1kbSLK|SYN|p59-FYN
Cytomap

12q21.33

6q21

Type of geneprotein-codingprotein-coding
Descriptionplasma membrane calcium-transporting ATPase 1ATPase, Ca++ transporting, plasma membrane 1plasma membrane calcium pumptyrosine-protein kinase FynFYN oncogene related to SRC, FGR, YESOKT3-induced calcium influx regulatorc-syn protooncogeneproto-oncogene Synproto-oncogene c-Fynsrc-like kinasesrc/yes-related noveltyrosine kinase p59fyn(T)
Modification date2020032220200327
UniProtAcc

P20020

C1orf168

Ensembl transtripts involved in fusion geneENST00000261173, ENST00000348959, 
ENST00000359142, ENST00000393164, 
ENST00000428670, 		ENST00000229470, 
ENST00000229471, ENST00000354650, 
ENST00000356013, ENST00000368667, 
ENST00000368678, ENST00000368682, 
ENST00000476769, ENST00000538466, 
Fusion gene scores* DoF score15 X 12 X 6=108019 X 14 X 12=3192
# samples 1327
** MAII scorelog2(13/1080*10)=-3.05444778402238
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(27/3192*10)=-3.56342933917152
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ATP2B1 [Title/Abstract] AND FYN [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointATP2B1(90065568)-FYN(111992100), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneATP2B1

GO:0051480

regulation of cytosolic calcium ion concentration

18029012

HgeneATP2B1

GO:1990034

calcium ion export across plasma membrane

18029012

TgeneFYN

GO:0050852

T cell receptor signaling pathway

7722293


check buttonFusion gene breakpoints across ATP2B1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across FYN (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/ABI494244ATP2B1chr12

90065568

+FYNchr6

111992100

+


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Fusion Gene ORF analysis for ATP2B1-FYN

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000261173ENST00000229470ATP2B1chr12

90065568

+FYNchr6

111992100

+
intron-intronENST00000261173ENST00000229471ATP2B1chr12

90065568

+FYNchr6

111992100

+
intron-intronENST00000261173ENST00000354650ATP2B1chr12

90065568

+FYNchr6

111992100

+
intron-intronENST00000261173ENST00000356013ATP2B1chr12

90065568

+FYNchr6

111992100

+
intron-intronENST00000261173ENST00000368667ATP2B1chr12

90065568

+FYNchr6

111992100

+
intron-intronENST00000261173ENST00000368678ATP2B1chr12

90065568

+FYNchr6

111992100

+
intron-intronENST00000261173ENST00000368682ATP2B1chr12

90065568

+FYNchr6

111992100

+
intron-intronENST00000261173ENST00000476769ATP2B1chr12

90065568

+FYNchr6

111992100

+
intron-intronENST00000261173ENST00000538466ATP2B1chr12

90065568

+FYNchr6

111992100

+
intron-intronENST00000348959ENST00000229470ATP2B1chr12

90065568

+FYNchr6

111992100

+
intron-intronENST00000348959ENST00000229471ATP2B1chr12

90065568

+FYNchr6

111992100

+
intron-intronENST00000348959ENST00000354650ATP2B1chr12

90065568

+FYNchr6

111992100

+
intron-intronENST00000348959ENST00000356013ATP2B1chr12

90065568

+FYNchr6

111992100

+
intron-intronENST00000348959ENST00000368667ATP2B1chr12

90065568

+FYNchr6

111992100

+
intron-intronENST00000348959ENST00000368678ATP2B1chr12

90065568

+FYNchr6

111992100

+
intron-intronENST00000348959ENST00000368682ATP2B1chr12

90065568

+FYNchr6

111992100

+
intron-intronENST00000348959ENST00000476769ATP2B1chr12

90065568

+FYNchr6

111992100

+
intron-intronENST00000348959ENST00000538466ATP2B1chr12

90065568

+FYNchr6

111992100

+
intron-intronENST00000359142ENST00000229470ATP2B1chr12

90065568

+FYNchr6

111992100

+
intron-intronENST00000359142ENST00000229471ATP2B1chr12

90065568

+FYNchr6

111992100

+
intron-intronENST00000359142ENST00000354650ATP2B1chr12

90065568

+FYNchr6

111992100

+
intron-intronENST00000359142ENST00000356013ATP2B1chr12

90065568

+FYNchr6

111992100

+
intron-intronENST00000359142ENST00000368667ATP2B1chr12

90065568

+FYNchr6

111992100

+
intron-intronENST00000359142ENST00000368678ATP2B1chr12

90065568

+FYNchr6

111992100

+
intron-intronENST00000359142ENST00000368682ATP2B1chr12

90065568

+FYNchr6

111992100

+
intron-intronENST00000359142ENST00000476769ATP2B1chr12

90065568

+FYNchr6

111992100

+
intron-intronENST00000359142ENST00000538466ATP2B1chr12

90065568

+FYNchr6

111992100

+
intron-intronENST00000393164ENST00000229470ATP2B1chr12

90065568

+FYNchr6

111992100

+
intron-intronENST00000393164ENST00000229471ATP2B1chr12

90065568

+FYNchr6

111992100

+
intron-intronENST00000393164ENST00000354650ATP2B1chr12

90065568

+FYNchr6

111992100

+
intron-intronENST00000393164ENST00000356013ATP2B1chr12

90065568

+FYNchr6

111992100

+
intron-intronENST00000393164ENST00000368667ATP2B1chr12

90065568

+FYNchr6

111992100

+
intron-intronENST00000393164ENST00000368678ATP2B1chr12

90065568

+FYNchr6

111992100

+
intron-intronENST00000393164ENST00000368682ATP2B1chr12

90065568

+FYNchr6

111992100

+
intron-intronENST00000393164ENST00000476769ATP2B1chr12

90065568

+FYNchr6

111992100

+
intron-intronENST00000393164ENST00000538466ATP2B1chr12

90065568

+FYNchr6

111992100

+
intron-intronENST00000428670ENST00000229470ATP2B1chr12

90065568

+FYNchr6

111992100

+
intron-intronENST00000428670ENST00000229471ATP2B1chr12

90065568

+FYNchr6

111992100

+
intron-intronENST00000428670ENST00000354650ATP2B1chr12

90065568

+FYNchr6

111992100

+
intron-intronENST00000428670ENST00000356013ATP2B1chr12

90065568

+FYNchr6

111992100

+
intron-intronENST00000428670ENST00000368667ATP2B1chr12

90065568

+FYNchr6

111992100

+
intron-intronENST00000428670ENST00000368678ATP2B1chr12

90065568

+FYNchr6

111992100

+
intron-intronENST00000428670ENST00000368682ATP2B1chr12

90065568

+FYNchr6

111992100

+
intron-intronENST00000428670ENST00000476769ATP2B1chr12

90065568

+FYNchr6

111992100

+
intron-intronENST00000428670ENST00000538466ATP2B1chr12

90065568

+FYNchr6

111992100

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for ATP2B1-FYN


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for ATP2B1-FYN


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:90065568/:111992100)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ATP2B1

P20020

FYN

C1orf168

FUNCTION: Catalyzes the hydrolysis of ATP coupled with the transport of calcium from the cytoplasm to the extracellular space thereby maintaining intracellular calcium homeostasis. Plays a role in blood pressure regulation through regulation of intracellular calcium concentration and nitric oxide production leading to regulation of vascular smooth muscle cells vasoconstriction. Positively regulates bone mineralization through absorption of calcium from the intestine. Plays dual roles in osteoclast differentiation and survival by regulating RANKL-induced calcium oscillations in preosteoclasts and mediating calcium extrusion in mature osteoclasts (By similarity). Regulates insulin sensitivity through calcium/calmodulin signaling pathway by regulating AKT1 activation and NOS3 activation in endothelial cells (PubMed:29104511). {ECO:0000250|UniProtKB:G5E829, ECO:0000269|PubMed:29104511}.728

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for ATP2B1-FYN


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for ATP2B1-FYN


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ATP2B1-FYN


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ATP2B1-FYN


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource