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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:RTFDC1-PCNT (FusionGDB2 ID:78529)

Fusion Gene Summary for RTFDC1-PCNT

check button Fusion gene summary
Fusion gene informationFusion gene name: RTFDC1-PCNT
Fusion gene ID: 78529
HgeneTgene
Gene symbol

RTFDC1

PCNT

Gene ID

51507

5116

Gene namereplication termination factor 2pericentrin
SynonymsC20orf43|CDAO5|HSPC164|RTFDC1|SHUJUN-3KEN|MOPD2|PCN|PCNT2|PCNTB|PCTN2|SCKL4
Cytomap

20q13.31

21q22.3

Type of geneprotein-codingprotein-coding
Descriptionreplication termination factor 2UPF0549 protein C20orf43protein RTF2 homologreplication termination factor 2 domain containing 1replication termination factor 2 domain-containing protein 1pericentrinkendrinpericentrin-2pericentrin-380pericentrin-B
Modification date2020031320200320
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000023939, ENST00000357348, 
ENST00000395881, ENST00000435342, 
ENST00000484084, 		ENST00000480896, 
ENST00000359568, 
Fusion gene scores* DoF score6 X 5 X 4=12011 X 12 X 5=660
# samples 611
** MAII scorelog2(6/120*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(11/660*10)=-2.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: RTFDC1 [Title/Abstract] AND PCNT [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointRTFDC1(55049827)-PCNT(47817928), # samples:2
Anticipated loss of major functional domain due to fusion event.RTFDC1-PCNT seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
RTFDC1-PCNT seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgenePCNT

GO:0060271

cilium assembly

15337773


check buttonFusion gene breakpoints across RTFDC1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across PCNT (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-AR-A252-01ARTFDC1chr20

55049827

+PCNTchr21

47817179

+
ChimerDB4BRCATCGA-AR-A252-01ARTFDC1chr20

55049827

+PCNTchr21

47817928

+


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Fusion Gene ORF analysis for RTFDC1-PCNT

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000023939ENST00000480896RTFDC1chr20

55049827

+PCNTchr21

47817179

+
5CDS-3UTRENST00000023939ENST00000480896RTFDC1chr20

55049827

+PCNTchr21

47817928

+
5CDS-3UTRENST00000357348ENST00000480896RTFDC1chr20

55049827

+PCNTchr21

47817179

+
5CDS-3UTRENST00000357348ENST00000480896RTFDC1chr20

55049827

+PCNTchr21

47817928

+
5CDS-3UTRENST00000395881ENST00000480896RTFDC1chr20

55049827

+PCNTchr21

47817179

+
5CDS-3UTRENST00000395881ENST00000480896RTFDC1chr20

55049827

+PCNTchr21

47817928

+
Frame-shiftENST00000023939ENST00000359568RTFDC1chr20

55049827

+PCNTchr21

47817179

+
Frame-shiftENST00000357348ENST00000359568RTFDC1chr20

55049827

+PCNTchr21

47817179

+
Frame-shiftENST00000395881ENST00000359568RTFDC1chr20

55049827

+PCNTchr21

47817179

+
In-frameENST00000023939ENST00000359568RTFDC1chr20

55049827

+PCNTchr21

47817928

+
In-frameENST00000357348ENST00000359568RTFDC1chr20

55049827

+PCNTchr21

47817928

+
In-frameENST00000395881ENST00000359568RTFDC1chr20

55049827

+PCNTchr21

47817928

+
intron-3CDSENST00000435342ENST00000359568RTFDC1chr20

55049827

+PCNTchr21

47817179

+
intron-3CDSENST00000435342ENST00000359568RTFDC1chr20

55049827

+PCNTchr21

47817928

+
intron-3CDSENST00000484084ENST00000359568RTFDC1chr20

55049827

+PCNTchr21

47817179

+
intron-3CDSENST00000484084ENST00000359568RTFDC1chr20

55049827

+PCNTchr21

47817928

+
intron-3UTRENST00000435342ENST00000480896RTFDC1chr20

55049827

+PCNTchr21

47817179

+
intron-3UTRENST00000435342ENST00000480896RTFDC1chr20

55049827

+PCNTchr21

47817928

+
intron-3UTRENST00000484084ENST00000480896RTFDC1chr20

55049827

+PCNTchr21

47817179

+
intron-3UTRENST00000484084ENST00000480896RTFDC1chr20

55049827

+PCNTchr21

47817928

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000023939RTFDC1chr2055049827+ENST00000359568PCNTchr2147817928+637236510759291940
ENST00000395881RTFDC1chr2055049827+ENST00000359568PCNTchr2147817928+63493428459061940
ENST00000357348RTFDC1chr2055049827+ENST00000359568PCNTchr2147817928+64114045659681970

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000023939ENST00000359568RTFDC1chr2055049827+PCNTchr2147817928+0.0092505330.9907494
ENST00000395881ENST00000359568RTFDC1chr2055049827+PCNTchr2147817928+0.0092355210.9907645
ENST00000357348ENST00000359568RTFDC1chr2055049827+PCNTchr2147817928+0.0086485350.9913515

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Fusion Genomic Features for RTFDC1-PCNT


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
RTFDC1chr2055049827+PCNTchr2147817927+6.84E-070.9999993
RTFDC1chr2055049827+PCNTchr2147817178+6.17E-070.9999994
RTFDC1chr2055049827+PCNTchr2147817927+6.84E-070.9999993
RTFDC1chr2055049827+PCNTchr2147817178+6.17E-070.9999994

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for RTFDC1-PCNT


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr20:55049827/chr21:47817928)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgenePCNTchr20:55049827chr21:47817928ENST0000035956821472064_208214823337.0Coiled coilOntology_term=ECO:0000255
TgenePCNTchr20:55049827chr21:47817928ENST0000035956821472536_308614823337.0Coiled coilOntology_term=ECO:0000255
TgenePCNTchr20:55049827chr21:47817928ENST0000035956821473195_320814823337.0RegionNote=Calmodulin-binding

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgenePCNTchr20:55049827chr21:47817928ENST0000035956821471010_114614823337.0Coiled coilOntology_term=ECO:0000255
TgenePCNTchr20:55049827chr21:47817928ENST0000035956821471299_194914823337.0Coiled coilOntology_term=ECO:0000255
TgenePCNTchr20:55049827chr21:47817928ENST000003595682147258_55314823337.0Coiled coilOntology_term=ECO:0000255
TgenePCNTchr20:55049827chr21:47817928ENST000003595682147675_83514823337.0Coiled coilOntology_term=ECO:0000255
TgenePCNTchr20:55049827chr21:47817928ENST000003595682147214_79514823337.0Compositional biasNote=Glu-rich


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Fusion Gene Sequence for RTFDC1-PCNT


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>78529_78529_1_RTFDC1-PCNT_RTFDC1_chr20_55049827_ENST00000023939_PCNT_chr21_47817928_ENST00000359568_length(transcript)=6372nt_BP=365nt
AGCGTGCTGCGTCACGGCGGTGCGCCGGAAGTGGCTGCGGATTTCGCCGGAAATCCCGGAAGTGACAGCTTTGGGGGTTTGCTGCTGGCT
CTGACTCCCGTCCTGCGATGGGTTGCGACGGGGGAACAATCCCCAAGAGGCATGAACTGGTGAAGGGGCCGAAGAAGGTTGAGAAGGTCG
ACAAAGATGCTGAATTAGTGGCCCAATGGAACTATTGTACTCTAAGTCAGGAAATATTAAGACGACCAATAGTTGCCTGTGAACTTGGCA
GACTTTATAACAAAGATGCCGTCATTGAATTTCTCTTGGACAAATCTGCAGAAAAGGCTCTTGGGAAGGCAGCATCTCACATTAAAAGCA
TTAAGGAGCAGGCAGCCGAGCGGGAGCACGAGCGCGAGGAGTTCCAGCAGGAGATTCAGAGGCTGGAGGGGCAGCTCCGCCAGGCGGCCA
AGCCGCAGCCCTGGGGCCCTCGCGACAGCCAGCAGGCGCCGCTGGATGGAGAGGTTGAGTTGTTACAACAAAAGTTGAGAGAAAAGTTGG
ATGAATTTAATGAATTGGCTATACAGAAAGAGTCGGCAGATAGACAAGTGTTAATGCAGGAAGAAGAAATTAAACGTCTGGAGGAGATGA
ACATCAACATCAGGAAAAAAGTGGCCCAGCTCCAGGAAGAAGTGGAAAAACAGAAAAACATCGTGAAAGGGCTGGAACAGGATAAAGAGG
TGTTAAAGAAACAGCAGATGAGTAGCTTGCTTCTGGCGTCCACGTTGCAGTCTACACTAGATGCAGGCAGATGTCCCGAGCCTCCTTCGG
GCAGCCCTCCTGAGGGTCCAGAAATACAGTTAGAGGTGACACAGAGAGCACTCCTGCGGCGCGAGAGCGAGGTTTTGGACTTAAAAGAAC
AGCTAGAAAAGATGAAAGGTGACTTAGAAAGTAAAAATGAAGAAATACTACATCTGAACTTAAAATTGGACATGCAGAACAGCCAGACTG
CTGTCAGCCTCAGAGAACTTGAGGAAGAGAACACGAGCTTGAAGGTCATATATACCAGAAGTTCTGAGATTGAAGAGCTGAAAGCCACTA
TTGAAAATCTGCAAGAGAATCAGAAACGATTACAAAAGGAGAAAGCAGAGGAAATTGAACAACTCCATGAAGTCATTGAGAAGCTGCAGC
ACGAGCTGTCCCTCATGGGGCCTGTGGTGCACGAAGTCAGCGACAGTCAGGCTGGCAGTCTGCAGAGCGAGCTGCTCTGCTCCCAGGCCG
GGGGCCCTCGTGGGCAGGCCCTACAGGGCGAGCTCGAGGCTGCGCTGGAAGCCAAGGAGGCCCTGAGCCGGCTGCTGGCTGACCAGGAGC
GCAGGCACAGCCAGGCCCTGGAGGCCCTGCAGCAGCGCCTCCAGGGCGCAGAGGAGGCTGCGGAGCTACAGCTGGCTGAGCTGGAGCGCA
ATGTAGCCCTCAGGGAGGCTGAGGTCGAAGACATGGCCTCCCGGATCCAGGAGTTCGAAGCGGCCCTGAAAGCAAAGGAAGCGACGATTG
CCGAGAGAAATTTAGAAATCGACGCTCTGAACCAGCGGAAGGCGGCCCACTCTGCCGAGCTGGAGGCCGTCCTGTTGGCCTTGGCCCGCA
TCCGCCGCGCCCTGGAGCAGCAGCCCCTGGCAGCCGGGGCGGCGCCTCCCGAGCTGCAGTGGCTCCGAGCGCAGTGTGCCCGCCTCAGCC
GCCAGCTGCAGGTGCTGCACCAGCGGTTCCTGAGGTGCCAGGTGGAGCTGGACAGGCGGCAGGCCCGCAGAGCCACAGCTCACACACGGG
TGCCCGGGGCCCACCCACAGCCTCGCATGGATGGTGGCGCCAAGGCCCAGGTCACCGGCGACGTGGAGGCCTCCCATGATGCTGCTTTGG
AGCCGGTTGTCCCTGACCCACAGGGTGATCTGCAGCCTGTCCTGGTGACGTTGAAGGATGCACCTCTCTGCAAGCAAGAAGGCGTGATGT
CAGTGCTCACCGTCTGCCAGAGGCAGCTGCAGTCGGAGCTGCTCTTGGTGAAAAATGAAATGCGCCTGAGTCTGGAGGACGGCGGCAAGG
GTAAAGAAAAAGTACTGGAAGATTGTCAGCTGCCGAAGGTCGATCTCGTAGCTCAGGTGAAACAGCTTCAGGAAAAACTGAACCGTTTGC
TGTATTCCATGACCTTCCAGAATGTGGATGCTGCCGACACCAAATCTCTGTGGCCCATGGCCTCAGCACACCTGTTGGAGAGCAGCTGGA
GTGATGATTCCTGTGACGGAGAAGAGCCTGACATATCACCCCACATAGACACATGTGATGCCAATACAGCCACGGGGGGTGTAACTGATG
TTATCAAAAATCAGGCCATAGACGCGTGTGATGCCAATACAACCCCAGGGGGTGTAACTGATGTTATCAAAAATTGGGATTCCTTGATAC
CAGATGAAATGCCAGATTCTCCCATTCAAGAAAAATCAGAATGTCAGGACATGTCTCTTTCTTCACCGACCAGCGTACTTGGTGGCTCCC
GCCACCAGAGCCACACTGCAGAGGCTGGGCCCCGGAAGAGCCCGGTCGGGATGCTGGACCTGTCTTCCTGGAGCTCCCCTGAGGTCCTCA
GGAAGGACTGGACCCTGGAGCCCTGGCCCAGCCTCCCCGTGACACCCCACTCAGGAGCCCTGAGCCTGTGCAGTGCCGACACATCCCTGG
GGGACAGGGCGGACACCTCGCTGCCACAGACCCAGGGGCCGGGGCTGCTTTGTTCCCCAGGCGTGTCTGCAGCAGCGCTGGCACTGCAGT
GGGCCGAGTCTCCGCCGGCTGACGACCACCATGTGCAGAGGACGGCTGTGGAGAAAGATGTCGAAGATTTTATCACAACATCCTTTGATT
CTCAAGAAACATTAAGTTCACCTCCTCCTGGATTAGAAGGAAAAGCTGATAGAAGTGAGAAAAGTGACGGCTCGGGTTTTGGAGCAAGAC
TGAGCCCGGGGTCAGGAGGCCCTGAGGCTCAAACTGCTGGTCCTGTGACCCCTGCTTCCATCTCTGGAAGGTTTCAGCCGCTGCCGGAAG
CCATGAAGGAGAAGGAAGTGCGTCCGAAGCACGTGAAGGCTTTACTGCAGATGGTGCGTGACGAGAGCCACCAGATCCTGGCGCTGTCAG
AAGGCCTTGCACCCCCAAGCGGCGAGCCACACCCACCCCGGAAGGAAGACGAGATACAGGACATCTCGCTCCATGGGGGAAAGACGCAGG
AAGTGCCCACCGCGTGCCCCGATTGGAGAGGGGACCTTCTGCAGGTTGTGCAAGAGGCCTTTGAAAAAGAGCAGGAGATGCAGGGGGTTG
AGCTGCAGCCCCGACTCAGTGGCTCAGATCTGGGGGGTCACAGCTCCCTGCTCGAAAGGCTGGAGAAGATCATCCGTGAGCAGGGAGACC
TGCAGGAAAAGTCCCTGGAGCATCTTCGCTTGCCGGACCGGAGCAGCCTGCTGTCCGAGATCCAGGCGCTGCGTGCCCAGCTGCGCATGA
CGCACCTGCAGAACCAGGAGAAGCTGCAGCACTTGCGCACGGCGCTGACAAGCGCAGAGGCGCGCGGGAGCCAGCAGGAGCACCAGCTGC
GCAGGCAGGTTGAACTGCTGGCTTATAAAGTAGAGCAGGAGAAGTGCATTGCTGGTGACTTGCAGAAGACGCTGAGTGAAGAGCAAGAGA
AGGCAAACAGCGTGCAGAAGCTCCTGGCGGCGGAGCAGACTGTAGTGCGAGATTTGAAGTCCGACCTCTGTGAGAGCAGGCAGAAGAGCG
AACAGCTGTCCCGGTCCCTCTGCGAGGTGCAGCAGGAGGTCCTCCAGCTGAGATCCATGCTGAGCAGTAAGGAGAACGAGCTGAAGGCCG
CGCTTCAGGAGCTGGAGAGTGAGCAGGGGAAGGGGCGTGCCCTGCAGAGCCAGCTGGAGGAGGAGCAGCTGCGGCACCTGCAGAGGGAGA
GCCAGAGTGCCAAGGCCCTGGAGGAGCTGCGGGCGTCTTTGGAGACACAGCGTGCTCAGAGCAGTCGACTCTGCGTGGCACTGAAACACG
AGCAGACGGCCAAGGACAACCTGCAGAAGGAGCTGCGTATCGAGCACTCACGCTGCGAGGCCTTGCTGGCTCAGGAGCGGAGCCAGCTCT
CTGAGCTCCAGAAGGACCTTGCGGCTGAGAAGAGCCGCACCCTGGAGCTGTCAGAGGCCTTGCGGCACGAGCGGCTCCTGACCGAGCAGC
TGAGCCAGAGGACACAGGAGGCTTGCGTGCACCAGGACACACAGGCCCATCACGCTCTGCTGCAGAAGCTGAAGGAGGAGAAGTCCCGGG
TGGTGGACTTGCAAGCGATGCTTGAAAAGGTGCAGCAGCAAGCCCTGCATTCTCAGCAGCAGCTTGAGGCTGAGGCTCAGAAGCACTGTG
AGGCGCTCAGGAGAGAGAAGGAGGTAAGTGCCACACTGAAGTCGACGGTGGAAGCCCTGCACACCCAAAAACGAGAGCTGAGATGCTCTC
TGGAGAGAGAGAGGGAGAAACCAGCGTGGTTGCAGGCAGAATTAGAGCAGTCACACCCACGGTTGAAAGAGCAAGAAGGACGCAAGGCTG
CGAGGAGGAGCGCGGAGGCCAGGCAGAGCCCAGCGGCTGCGGAGCAGTGGAGGAAGTGGCAGAGAGACAAGGAGAAGCTGCGAGAATTAG
AACTGCAGCGTCAGCGTGACTTGCATAAGATCAAGCAGCTTCAGCAGACAGTGAGAGACCTGGAGTCGAAGGACGAGGTGCCTGGCAGCC
GCCTCCACCTAGGTTCTGCCCGCAGGGCTGCCGGCTCGGATGCGGACCACCTCCGGGAACAGCAGCGAGAGCTGGAGGCGATGAGGCAGC
GGCTGCTCTCTGCCGCCCGGCTTCTCACCAGCTTCACCAGCCAGGCCGTGGACAGGACAGTTAATGATTGGACGTCATCCAATGAGAAAG
CAGTGATGTCTTTACTGCACACGTTGGAGGAGCTGAAGTCTGACTTGAGCAGGCCCACCTCCTCCCAGAAAAAAATGGCAGCAGAGCTGC
AGTTCCAGTTTGTGGACGTCCTGCTGAAAGACAATGTTTCCCTCACAAAAGCGCTCAGCACGGTGACCCAGGAGAAGCTGGAGCTGAGCA
GAGCCGTGTCTAAGCTTGAGAAGTTGCTGAAGCACCATCTGCAGAAGGGCTGCAGCCCAAGCAGGTCGGAAAGGTCTGCTTGGAAGCCAG
ACGAAACGGCTCCACAGAGTTCCCTGAGGCGCCCAGACCCCGGCCGGCTTCCACCAGCTGCCAGCGAGGAAGCACACACCAGCAATGTCA
AGATGGAAAAATTGTACCTGCATTACTTGAGAGCAGAGAGCTTTAGAAAAGCTCTGATTTATCAAAAGAAGTATCTTTTGCTGTTGATTG
GTGGATTCCAGGATTCTGAACAAGAAACACTCTCCATGATTGCCCATTTGGGGGTATTTCCTTCCAAAGCAGAACGGAAAATCACATCTC
GTCCTTTCACCAGGTTCCGCACGGCCGTCAGGGTGGTCATTGCAATATTAAGATTACGTTTTTTGGTTAAGAAATGGCAAGAAGTAGATC
GGAAAGGAGCTCTGGCACAAGGCAAAGCCCCTCGCCCAGGGCCCCGAGCACGACAGCCGCAGTCTCCACCCAGAACCAGAGAGTCCCCCC
CAACCCGGGATGTACCCTCTGGCCACACCAGGGACCCTGCCAGAGGCCGCAGACTGGCAGCAGCAGCCTCCCCACACAGTGGGGGAAGAG
CCACTCCATCCCCAAATTCAAGATTAGAAAGATCCCTGACTGCTTCTCAAGATCCAGAACATTCCTTGACAGAGTATATTCACCATTTAG
AAGTGATCCAGCAAAGATTGGGAGGGGTACTACCAGATTCTACTTCAAAGAAATCCTGCCACCCGATGATTAAACAGTGAATAAAATGTC
ATGGCTCTTTCCTGCGACAATTCTATTTGAGGAAAAGATTTGTTTTTCCCTTTTCCCAAGGAAGCTCGTGGGACAGCATGGGCACTACTC
TTCATGTGCGGTGACACCAGCCCCCAGATGCCTTGAATTAAGTGTCCTCACCTTTATGCATGACTGCAAAGCCAGCTGGAGCATTTTCTA
TGGAGCCTCCGTATGTTTTAGGCCCATGACCTTCGTGAGGTGACGGGCACTCACTCCCATGAGCCCTGGCTGTGTGCTGTTGTGTGCCTA
TCGGCAGATCCATCCTTCCTGCCTCCAAGGAGGATACACAGAGAATGGCTTCCTGTTGTTTTGTTTATTTTCTTAACGTGTACAGATGGA

>78529_78529_1_RTFDC1-PCNT_RTFDC1_chr20_55049827_ENST00000023939_PCNT_chr21_47817928_ENST00000359568_length(amino acids)=1940AA_BP=86
MGCDGGTIPKRHELVKGPKKVEKVDKDAELVAQWNYCTLSQEILRRPIVACELGRLYNKDAVIEFLLDKSAEKALGKAASHIKSIKEQAA
EREHEREEFQQEIQRLEGQLRQAAKPQPWGPRDSQQAPLDGEVELLQQKLREKLDEFNELAIQKESADRQVLMQEEEIKRLEEMNINIRK
KVAQLQEEVEKQKNIVKGLEQDKEVLKKQQMSSLLLASTLQSTLDAGRCPEPPSGSPPEGPEIQLEVTQRALLRRESEVLDLKEQLEKMK
GDLESKNEEILHLNLKLDMQNSQTAVSLRELEEENTSLKVIYTRSSEIEELKATIENLQENQKRLQKEKAEEIEQLHEVIEKLQHELSLM
GPVVHEVSDSQAGSLQSELLCSQAGGPRGQALQGELEAALEAKEALSRLLADQERRHSQALEALQQRLQGAEEAAELQLAELERNVALRE
AEVEDMASRIQEFEAALKAKEATIAERNLEIDALNQRKAAHSAELEAVLLALARIRRALEQQPLAAGAAPPELQWLRAQCARLSRQLQVL
HQRFLRCQVELDRRQARRATAHTRVPGAHPQPRMDGGAKAQVTGDVEASHDAALEPVVPDPQGDLQPVLVTLKDAPLCKQEGVMSVLTVC
QRQLQSELLLVKNEMRLSLEDGGKGKEKVLEDCQLPKVDLVAQVKQLQEKLNRLLYSMTFQNVDAADTKSLWPMASAHLLESSWSDDSCD
GEEPDISPHIDTCDANTATGGVTDVIKNQAIDACDANTTPGGVTDVIKNWDSLIPDEMPDSPIQEKSECQDMSLSSPTSVLGGSRHQSHT
AEAGPRKSPVGMLDLSSWSSPEVLRKDWTLEPWPSLPVTPHSGALSLCSADTSLGDRADTSLPQTQGPGLLCSPGVSAAALALQWAESPP
ADDHHVQRTAVEKDVEDFITTSFDSQETLSSPPPGLEGKADRSEKSDGSGFGARLSPGSGGPEAQTAGPVTPASISGRFQPLPEAMKEKE
VRPKHVKALLQMVRDESHQILALSEGLAPPSGEPHPPRKEDEIQDISLHGGKTQEVPTACPDWRGDLLQVVQEAFEKEQEMQGVELQPRL
SGSDLGGHSSLLERLEKIIREQGDLQEKSLEHLRLPDRSSLLSEIQALRAQLRMTHLQNQEKLQHLRTALTSAEARGSQQEHQLRRQVEL
LAYKVEQEKCIAGDLQKTLSEEQEKANSVQKLLAAEQTVVRDLKSDLCESRQKSEQLSRSLCEVQQEVLQLRSMLSSKENELKAALQELE
SEQGKGRALQSQLEEEQLRHLQRESQSAKALEELRASLETQRAQSSRLCVALKHEQTAKDNLQKELRIEHSRCEALLAQERSQLSELQKD
LAAEKSRTLELSEALRHERLLTEQLSQRTQEACVHQDTQAHHALLQKLKEEKSRVVDLQAMLEKVQQQALHSQQQLEAEAQKHCEALRRE
KEVSATLKSTVEALHTQKRELRCSLEREREKPAWLQAELEQSHPRLKEQEGRKAARRSAEARQSPAAAEQWRKWQRDKEKLRELELQRQR
DLHKIKQLQQTVRDLESKDEVPGSRLHLGSARRAAGSDADHLREQQRELEAMRQRLLSAARLLTSFTSQAVDRTVNDWTSSNEKAVMSLL
HTLEELKSDLSRPTSSQKKMAAELQFQFVDVLLKDNVSLTKALSTVTQEKLELSRAVSKLEKLLKHHLQKGCSPSRSERSAWKPDETAPQ
SSLRRPDPGRLPPAASEEAHTSNVKMEKLYLHYLRAESFRKALIYQKKYLLLLIGGFQDSEQETLSMIAHLGVFPSKAERKITSRPFTRF
RTAVRVVIAILRLRFLVKKWQEVDRKGALAQGKAPRPGPRARQPQSPPRTRESPPTRDVPSGHTRDPARGRRLAAAASPHSGGRATPSPN

--------------------------------------------------------------
>78529_78529_2_RTFDC1-PCNT_RTFDC1_chr20_55049827_ENST00000357348_PCNT_chr21_47817928_ENST00000359568_length(transcript)=6411nt_BP=404nt
AATCCCGGAAGTGACAGCTTTGGGGGTTTGCTGCTGGCTCTGACTCCCGTCCTGCGATGGGTTGCGACGGGGGAACAATCCCCAAGAGGC
ATGAACTGGTGAAGGGGCCGAAGAAGGTTGAGAAGATTTGGCATTTGAAGAATGGGAAAGAGTGGTGCAGTCTACACAGTGAAGGAAAAA
ACAAGAACGGGAAGGAGTGGGACATGGAATATGATGTCGACAAAGATGCTGAATTAGTGGCCCAATGGAACTATTGTACTCTAAGTCAGG
AAATATTAAGACGACCAATAGTTGCCTGTGAACTTGGCAGACTTTATAACAAAGATGCCGTCATTGAATTTCTCTTGGACAAATCTGCAG
AAAAGGCTCTTGGGAAGGCAGCATCTCACATTAAAAGCATTAAGGAGCAGGCAGCCGAGCGGGAGCACGAGCGCGAGGAGTTCCAGCAGG
AGATTCAGAGGCTGGAGGGGCAGCTCCGCCAGGCGGCCAAGCCGCAGCCCTGGGGCCCTCGCGACAGCCAGCAGGCGCCGCTGGATGGAG
AGGTTGAGTTGTTACAACAAAAGTTGAGAGAAAAGTTGGATGAATTTAATGAATTGGCTATACAGAAAGAGTCGGCAGATAGACAAGTGT
TAATGCAGGAAGAAGAAATTAAACGTCTGGAGGAGATGAACATCAACATCAGGAAAAAAGTGGCCCAGCTCCAGGAAGAAGTGGAAAAAC
AGAAAAACATCGTGAAAGGGCTGGAACAGGATAAAGAGGTGTTAAAGAAACAGCAGATGAGTAGCTTGCTTCTGGCGTCCACGTTGCAGT
CTACACTAGATGCAGGCAGATGTCCCGAGCCTCCTTCGGGCAGCCCTCCTGAGGGTCCAGAAATACAGTTAGAGGTGACACAGAGAGCAC
TCCTGCGGCGCGAGAGCGAGGTTTTGGACTTAAAAGAACAGCTAGAAAAGATGAAAGGTGACTTAGAAAGTAAAAATGAAGAAATACTAC
ATCTGAACTTAAAATTGGACATGCAGAACAGCCAGACTGCTGTCAGCCTCAGAGAACTTGAGGAAGAGAACACGAGCTTGAAGGTCATAT
ATACCAGAAGTTCTGAGATTGAAGAGCTGAAAGCCACTATTGAAAATCTGCAAGAGAATCAGAAACGATTACAAAAGGAGAAAGCAGAGG
AAATTGAACAACTCCATGAAGTCATTGAGAAGCTGCAGCACGAGCTGTCCCTCATGGGGCCTGTGGTGCACGAAGTCAGCGACAGTCAGG
CTGGCAGTCTGCAGAGCGAGCTGCTCTGCTCCCAGGCCGGGGGCCCTCGTGGGCAGGCCCTACAGGGCGAGCTCGAGGCTGCGCTGGAAG
CCAAGGAGGCCCTGAGCCGGCTGCTGGCTGACCAGGAGCGCAGGCACAGCCAGGCCCTGGAGGCCCTGCAGCAGCGCCTCCAGGGCGCAG
AGGAGGCTGCGGAGCTACAGCTGGCTGAGCTGGAGCGCAATGTAGCCCTCAGGGAGGCTGAGGTCGAAGACATGGCCTCCCGGATCCAGG
AGTTCGAAGCGGCCCTGAAAGCAAAGGAAGCGACGATTGCCGAGAGAAATTTAGAAATCGACGCTCTGAACCAGCGGAAGGCGGCCCACT
CTGCCGAGCTGGAGGCCGTCCTGTTGGCCTTGGCCCGCATCCGCCGCGCCCTGGAGCAGCAGCCCCTGGCAGCCGGGGCGGCGCCTCCCG
AGCTGCAGTGGCTCCGAGCGCAGTGTGCCCGCCTCAGCCGCCAGCTGCAGGTGCTGCACCAGCGGTTCCTGAGGTGCCAGGTGGAGCTGG
ACAGGCGGCAGGCCCGCAGAGCCACAGCTCACACACGGGTGCCCGGGGCCCACCCACAGCCTCGCATGGATGGTGGCGCCAAGGCCCAGG
TCACCGGCGACGTGGAGGCCTCCCATGATGCTGCTTTGGAGCCGGTTGTCCCTGACCCACAGGGTGATCTGCAGCCTGTCCTGGTGACGT
TGAAGGATGCACCTCTCTGCAAGCAAGAAGGCGTGATGTCAGTGCTCACCGTCTGCCAGAGGCAGCTGCAGTCGGAGCTGCTCTTGGTGA
AAAATGAAATGCGCCTGAGTCTGGAGGACGGCGGCAAGGGTAAAGAAAAAGTACTGGAAGATTGTCAGCTGCCGAAGGTCGATCTCGTAG
CTCAGGTGAAACAGCTTCAGGAAAAACTGAACCGTTTGCTGTATTCCATGACCTTCCAGAATGTGGATGCTGCCGACACCAAATCTCTGT
GGCCCATGGCCTCAGCACACCTGTTGGAGAGCAGCTGGAGTGATGATTCCTGTGACGGAGAAGAGCCTGACATATCACCCCACATAGACA
CATGTGATGCCAATACAGCCACGGGGGGTGTAACTGATGTTATCAAAAATCAGGCCATAGACGCGTGTGATGCCAATACAACCCCAGGGG
GTGTAACTGATGTTATCAAAAATTGGGATTCCTTGATACCAGATGAAATGCCAGATTCTCCCATTCAAGAAAAATCAGAATGTCAGGACA
TGTCTCTTTCTTCACCGACCAGCGTACTTGGTGGCTCCCGCCACCAGAGCCACACTGCAGAGGCTGGGCCCCGGAAGAGCCCGGTCGGGA
TGCTGGACCTGTCTTCCTGGAGCTCCCCTGAGGTCCTCAGGAAGGACTGGACCCTGGAGCCCTGGCCCAGCCTCCCCGTGACACCCCACT
CAGGAGCCCTGAGCCTGTGCAGTGCCGACACATCCCTGGGGGACAGGGCGGACACCTCGCTGCCACAGACCCAGGGGCCGGGGCTGCTTT
GTTCCCCAGGCGTGTCTGCAGCAGCGCTGGCACTGCAGTGGGCCGAGTCTCCGCCGGCTGACGACCACCATGTGCAGAGGACGGCTGTGG
AGAAAGATGTCGAAGATTTTATCACAACATCCTTTGATTCTCAAGAAACATTAAGTTCACCTCCTCCTGGATTAGAAGGAAAAGCTGATA
GAAGTGAGAAAAGTGACGGCTCGGGTTTTGGAGCAAGACTGAGCCCGGGGTCAGGAGGCCCTGAGGCTCAAACTGCTGGTCCTGTGACCC
CTGCTTCCATCTCTGGAAGGTTTCAGCCGCTGCCGGAAGCCATGAAGGAGAAGGAAGTGCGTCCGAAGCACGTGAAGGCTTTACTGCAGA
TGGTGCGTGACGAGAGCCACCAGATCCTGGCGCTGTCAGAAGGCCTTGCACCCCCAAGCGGCGAGCCACACCCACCCCGGAAGGAAGACG
AGATACAGGACATCTCGCTCCATGGGGGAAAGACGCAGGAAGTGCCCACCGCGTGCCCCGATTGGAGAGGGGACCTTCTGCAGGTTGTGC
AAGAGGCCTTTGAAAAAGAGCAGGAGATGCAGGGGGTTGAGCTGCAGCCCCGACTCAGTGGCTCAGATCTGGGGGGTCACAGCTCCCTGC
TCGAAAGGCTGGAGAAGATCATCCGTGAGCAGGGAGACCTGCAGGAAAAGTCCCTGGAGCATCTTCGCTTGCCGGACCGGAGCAGCCTGC
TGTCCGAGATCCAGGCGCTGCGTGCCCAGCTGCGCATGACGCACCTGCAGAACCAGGAGAAGCTGCAGCACTTGCGCACGGCGCTGACAA
GCGCAGAGGCGCGCGGGAGCCAGCAGGAGCACCAGCTGCGCAGGCAGGTTGAACTGCTGGCTTATAAAGTAGAGCAGGAGAAGTGCATTG
CTGGTGACTTGCAGAAGACGCTGAGTGAAGAGCAAGAGAAGGCAAACAGCGTGCAGAAGCTCCTGGCGGCGGAGCAGACTGTAGTGCGAG
ATTTGAAGTCCGACCTCTGTGAGAGCAGGCAGAAGAGCGAACAGCTGTCCCGGTCCCTCTGCGAGGTGCAGCAGGAGGTCCTCCAGCTGA
GATCCATGCTGAGCAGTAAGGAGAACGAGCTGAAGGCCGCGCTTCAGGAGCTGGAGAGTGAGCAGGGGAAGGGGCGTGCCCTGCAGAGCC
AGCTGGAGGAGGAGCAGCTGCGGCACCTGCAGAGGGAGAGCCAGAGTGCCAAGGCCCTGGAGGAGCTGCGGGCGTCTTTGGAGACACAGC
GTGCTCAGAGCAGTCGACTCTGCGTGGCACTGAAACACGAGCAGACGGCCAAGGACAACCTGCAGAAGGAGCTGCGTATCGAGCACTCAC
GCTGCGAGGCCTTGCTGGCTCAGGAGCGGAGCCAGCTCTCTGAGCTCCAGAAGGACCTTGCGGCTGAGAAGAGCCGCACCCTGGAGCTGT
CAGAGGCCTTGCGGCACGAGCGGCTCCTGACCGAGCAGCTGAGCCAGAGGACACAGGAGGCTTGCGTGCACCAGGACACACAGGCCCATC
ACGCTCTGCTGCAGAAGCTGAAGGAGGAGAAGTCCCGGGTGGTGGACTTGCAAGCGATGCTTGAAAAGGTGCAGCAGCAAGCCCTGCATT
CTCAGCAGCAGCTTGAGGCTGAGGCTCAGAAGCACTGTGAGGCGCTCAGGAGAGAGAAGGAGGTAAGTGCCACACTGAAGTCGACGGTGG
AAGCCCTGCACACCCAAAAACGAGAGCTGAGATGCTCTCTGGAGAGAGAGAGGGAGAAACCAGCGTGGTTGCAGGCAGAATTAGAGCAGT
CACACCCACGGTTGAAAGAGCAAGAAGGACGCAAGGCTGCGAGGAGGAGCGCGGAGGCCAGGCAGAGCCCAGCGGCTGCGGAGCAGTGGA
GGAAGTGGCAGAGAGACAAGGAGAAGCTGCGAGAATTAGAACTGCAGCGTCAGCGTGACTTGCATAAGATCAAGCAGCTTCAGCAGACAG
TGAGAGACCTGGAGTCGAAGGACGAGGTGCCTGGCAGCCGCCTCCACCTAGGTTCTGCCCGCAGGGCTGCCGGCTCGGATGCGGACCACC
TCCGGGAACAGCAGCGAGAGCTGGAGGCGATGAGGCAGCGGCTGCTCTCTGCCGCCCGGCTTCTCACCAGCTTCACCAGCCAGGCCGTGG
ACAGGACAGTTAATGATTGGACGTCATCCAATGAGAAAGCAGTGATGTCTTTACTGCACACGTTGGAGGAGCTGAAGTCTGACTTGAGCA
GGCCCACCTCCTCCCAGAAAAAAATGGCAGCAGAGCTGCAGTTCCAGTTTGTGGACGTCCTGCTGAAAGACAATGTTTCCCTCACAAAAG
CGCTCAGCACGGTGACCCAGGAGAAGCTGGAGCTGAGCAGAGCCGTGTCTAAGCTTGAGAAGTTGCTGAAGCACCATCTGCAGAAGGGCT
GCAGCCCAAGCAGGTCGGAAAGGTCTGCTTGGAAGCCAGACGAAACGGCTCCACAGAGTTCCCTGAGGCGCCCAGACCCCGGCCGGCTTC
CACCAGCTGCCAGCGAGGAAGCACACACCAGCAATGTCAAGATGGAAAAATTGTACCTGCATTACTTGAGAGCAGAGAGCTTTAGAAAAG
CTCTGATTTATCAAAAGAAGTATCTTTTGCTGTTGATTGGTGGATTCCAGGATTCTGAACAAGAAACACTCTCCATGATTGCCCATTTGG
GGGTATTTCCTTCCAAAGCAGAACGGAAAATCACATCTCGTCCTTTCACCAGGTTCCGCACGGCCGTCAGGGTGGTCATTGCAATATTAA
GATTACGTTTTTTGGTTAAGAAATGGCAAGAAGTAGATCGGAAAGGAGCTCTGGCACAAGGCAAAGCCCCTCGCCCAGGGCCCCGAGCAC
GACAGCCGCAGTCTCCACCCAGAACCAGAGAGTCCCCCCCAACCCGGGATGTACCCTCTGGCCACACCAGGGACCCTGCCAGAGGCCGCA
GACTGGCAGCAGCAGCCTCCCCACACAGTGGGGGAAGAGCCACTCCATCCCCAAATTCAAGATTAGAAAGATCCCTGACTGCTTCTCAAG
ATCCAGAACATTCCTTGACAGAGTATATTCACCATTTAGAAGTGATCCAGCAAAGATTGGGAGGGGTACTACCAGATTCTACTTCAAAGA
AATCCTGCCACCCGATGATTAAACAGTGAATAAAATGTCATGGCTCTTTCCTGCGACAATTCTATTTGAGGAAAAGATTTGTTTTTCCCT
TTTCCCAAGGAAGCTCGTGGGACAGCATGGGCACTACTCTTCATGTGCGGTGACACCAGCCCCCAGATGCCTTGAATTAAGTGTCCTCAC
CTTTATGCATGACTGCAAAGCCAGCTGGAGCATTTTCTATGGAGCCTCCGTATGTTTTAGGCCCATGACCTTCGTGAGGTGACGGGCACT
CACTCCCATGAGCCCTGGCTGTGTGCTGTTGTGTGCCTATCGGCAGATCCATCCTTCCTGCCTCCAAGGAGGATACACAGAGAATGGCTT
CCTGTTGTTTTGTTTATTTTCTTAACGTGTACAGATGGAAACTTCATTTAAAAATAAAAACAAAACAACTCAAAAAGGAATAAAATTTAA

>78529_78529_2_RTFDC1-PCNT_RTFDC1_chr20_55049827_ENST00000357348_PCNT_chr21_47817928_ENST00000359568_length(amino acids)=1970AA_BP=116
MGCDGGTIPKRHELVKGPKKVEKIWHLKNGKEWCSLHSEGKNKNGKEWDMEYDVDKDAELVAQWNYCTLSQEILRRPIVACELGRLYNKD
AVIEFLLDKSAEKALGKAASHIKSIKEQAAEREHEREEFQQEIQRLEGQLRQAAKPQPWGPRDSQQAPLDGEVELLQQKLREKLDEFNEL
AIQKESADRQVLMQEEEIKRLEEMNINIRKKVAQLQEEVEKQKNIVKGLEQDKEVLKKQQMSSLLLASTLQSTLDAGRCPEPPSGSPPEG
PEIQLEVTQRALLRRESEVLDLKEQLEKMKGDLESKNEEILHLNLKLDMQNSQTAVSLRELEEENTSLKVIYTRSSEIEELKATIENLQE
NQKRLQKEKAEEIEQLHEVIEKLQHELSLMGPVVHEVSDSQAGSLQSELLCSQAGGPRGQALQGELEAALEAKEALSRLLADQERRHSQA
LEALQQRLQGAEEAAELQLAELERNVALREAEVEDMASRIQEFEAALKAKEATIAERNLEIDALNQRKAAHSAELEAVLLALARIRRALE
QQPLAAGAAPPELQWLRAQCARLSRQLQVLHQRFLRCQVELDRRQARRATAHTRVPGAHPQPRMDGGAKAQVTGDVEASHDAALEPVVPD
PQGDLQPVLVTLKDAPLCKQEGVMSVLTVCQRQLQSELLLVKNEMRLSLEDGGKGKEKVLEDCQLPKVDLVAQVKQLQEKLNRLLYSMTF
QNVDAADTKSLWPMASAHLLESSWSDDSCDGEEPDISPHIDTCDANTATGGVTDVIKNQAIDACDANTTPGGVTDVIKNWDSLIPDEMPD
SPIQEKSECQDMSLSSPTSVLGGSRHQSHTAEAGPRKSPVGMLDLSSWSSPEVLRKDWTLEPWPSLPVTPHSGALSLCSADTSLGDRADT
SLPQTQGPGLLCSPGVSAAALALQWAESPPADDHHVQRTAVEKDVEDFITTSFDSQETLSSPPPGLEGKADRSEKSDGSGFGARLSPGSG
GPEAQTAGPVTPASISGRFQPLPEAMKEKEVRPKHVKALLQMVRDESHQILALSEGLAPPSGEPHPPRKEDEIQDISLHGGKTQEVPTAC
PDWRGDLLQVVQEAFEKEQEMQGVELQPRLSGSDLGGHSSLLERLEKIIREQGDLQEKSLEHLRLPDRSSLLSEIQALRAQLRMTHLQNQ
EKLQHLRTALTSAEARGSQQEHQLRRQVELLAYKVEQEKCIAGDLQKTLSEEQEKANSVQKLLAAEQTVVRDLKSDLCESRQKSEQLSRS
LCEVQQEVLQLRSMLSSKENELKAALQELESEQGKGRALQSQLEEEQLRHLQRESQSAKALEELRASLETQRAQSSRLCVALKHEQTAKD
NLQKELRIEHSRCEALLAQERSQLSELQKDLAAEKSRTLELSEALRHERLLTEQLSQRTQEACVHQDTQAHHALLQKLKEEKSRVVDLQA
MLEKVQQQALHSQQQLEAEAQKHCEALRREKEVSATLKSTVEALHTQKRELRCSLEREREKPAWLQAELEQSHPRLKEQEGRKAARRSAE
ARQSPAAAEQWRKWQRDKEKLRELELQRQRDLHKIKQLQQTVRDLESKDEVPGSRLHLGSARRAAGSDADHLREQQRELEAMRQRLLSAA
RLLTSFTSQAVDRTVNDWTSSNEKAVMSLLHTLEELKSDLSRPTSSQKKMAAELQFQFVDVLLKDNVSLTKALSTVTQEKLELSRAVSKL
EKLLKHHLQKGCSPSRSERSAWKPDETAPQSSLRRPDPGRLPPAASEEAHTSNVKMEKLYLHYLRAESFRKALIYQKKYLLLLIGGFQDS
EQETLSMIAHLGVFPSKAERKITSRPFTRFRTAVRVVIAILRLRFLVKKWQEVDRKGALAQGKAPRPGPRARQPQSPPRTRESPPTRDVP

--------------------------------------------------------------
>78529_78529_3_RTFDC1-PCNT_RTFDC1_chr20_55049827_ENST00000395881_PCNT_chr21_47817928_ENST00000359568_length(transcript)=6349nt_BP=342nt
GCCGGAAGTGGCTGCGGATTTCGCCGGAAATCCCGGAAGTGACAGCTTTGGGGGTTTGCTGCTGGCTCTGACTCCCGTCCTGCGATGGGT
TGCGACGGGGGAACAATCCCCAAGAGGCATGAACTGGTGAAGGGGCCGAAGAAGGTTGAGAAGGTCGACAAAGATGCTGAATTAGTGGCC
CAATGGAACTATTGTACTCTAAGTCAGGAAATATTAAGACGACCAATAGTTGCCTGTGAACTTGGCAGACTTTATAACAAAGATGCCGTC
ATTGAATTTCTCTTGGACAAATCTGCAGAAAAGGCTCTTGGGAAGGCAGCATCTCACATTAAAAGCATTAAGGAGCAGGCAGCCGAGCGG
GAGCACGAGCGCGAGGAGTTCCAGCAGGAGATTCAGAGGCTGGAGGGGCAGCTCCGCCAGGCGGCCAAGCCGCAGCCCTGGGGCCCTCGC
GACAGCCAGCAGGCGCCGCTGGATGGAGAGGTTGAGTTGTTACAACAAAAGTTGAGAGAAAAGTTGGATGAATTTAATGAATTGGCTATA
CAGAAAGAGTCGGCAGATAGACAAGTGTTAATGCAGGAAGAAGAAATTAAACGTCTGGAGGAGATGAACATCAACATCAGGAAAAAAGTG
GCCCAGCTCCAGGAAGAAGTGGAAAAACAGAAAAACATCGTGAAAGGGCTGGAACAGGATAAAGAGGTGTTAAAGAAACAGCAGATGAGT
AGCTTGCTTCTGGCGTCCACGTTGCAGTCTACACTAGATGCAGGCAGATGTCCCGAGCCTCCTTCGGGCAGCCCTCCTGAGGGTCCAGAA
ATACAGTTAGAGGTGACACAGAGAGCACTCCTGCGGCGCGAGAGCGAGGTTTTGGACTTAAAAGAACAGCTAGAAAAGATGAAAGGTGAC
TTAGAAAGTAAAAATGAAGAAATACTACATCTGAACTTAAAATTGGACATGCAGAACAGCCAGACTGCTGTCAGCCTCAGAGAACTTGAG
GAAGAGAACACGAGCTTGAAGGTCATATATACCAGAAGTTCTGAGATTGAAGAGCTGAAAGCCACTATTGAAAATCTGCAAGAGAATCAG
AAACGATTACAAAAGGAGAAAGCAGAGGAAATTGAACAACTCCATGAAGTCATTGAGAAGCTGCAGCACGAGCTGTCCCTCATGGGGCCT
GTGGTGCACGAAGTCAGCGACAGTCAGGCTGGCAGTCTGCAGAGCGAGCTGCTCTGCTCCCAGGCCGGGGGCCCTCGTGGGCAGGCCCTA
CAGGGCGAGCTCGAGGCTGCGCTGGAAGCCAAGGAGGCCCTGAGCCGGCTGCTGGCTGACCAGGAGCGCAGGCACAGCCAGGCCCTGGAG
GCCCTGCAGCAGCGCCTCCAGGGCGCAGAGGAGGCTGCGGAGCTACAGCTGGCTGAGCTGGAGCGCAATGTAGCCCTCAGGGAGGCTGAG
GTCGAAGACATGGCCTCCCGGATCCAGGAGTTCGAAGCGGCCCTGAAAGCAAAGGAAGCGACGATTGCCGAGAGAAATTTAGAAATCGAC
GCTCTGAACCAGCGGAAGGCGGCCCACTCTGCCGAGCTGGAGGCCGTCCTGTTGGCCTTGGCCCGCATCCGCCGCGCCCTGGAGCAGCAG
CCCCTGGCAGCCGGGGCGGCGCCTCCCGAGCTGCAGTGGCTCCGAGCGCAGTGTGCCCGCCTCAGCCGCCAGCTGCAGGTGCTGCACCAG
CGGTTCCTGAGGTGCCAGGTGGAGCTGGACAGGCGGCAGGCCCGCAGAGCCACAGCTCACACACGGGTGCCCGGGGCCCACCCACAGCCT
CGCATGGATGGTGGCGCCAAGGCCCAGGTCACCGGCGACGTGGAGGCCTCCCATGATGCTGCTTTGGAGCCGGTTGTCCCTGACCCACAG
GGTGATCTGCAGCCTGTCCTGGTGACGTTGAAGGATGCACCTCTCTGCAAGCAAGAAGGCGTGATGTCAGTGCTCACCGTCTGCCAGAGG
CAGCTGCAGTCGGAGCTGCTCTTGGTGAAAAATGAAATGCGCCTGAGTCTGGAGGACGGCGGCAAGGGTAAAGAAAAAGTACTGGAAGAT
TGTCAGCTGCCGAAGGTCGATCTCGTAGCTCAGGTGAAACAGCTTCAGGAAAAACTGAACCGTTTGCTGTATTCCATGACCTTCCAGAAT
GTGGATGCTGCCGACACCAAATCTCTGTGGCCCATGGCCTCAGCACACCTGTTGGAGAGCAGCTGGAGTGATGATTCCTGTGACGGAGAA
GAGCCTGACATATCACCCCACATAGACACATGTGATGCCAATACAGCCACGGGGGGTGTAACTGATGTTATCAAAAATCAGGCCATAGAC
GCGTGTGATGCCAATACAACCCCAGGGGGTGTAACTGATGTTATCAAAAATTGGGATTCCTTGATACCAGATGAAATGCCAGATTCTCCC
ATTCAAGAAAAATCAGAATGTCAGGACATGTCTCTTTCTTCACCGACCAGCGTACTTGGTGGCTCCCGCCACCAGAGCCACACTGCAGAG
GCTGGGCCCCGGAAGAGCCCGGTCGGGATGCTGGACCTGTCTTCCTGGAGCTCCCCTGAGGTCCTCAGGAAGGACTGGACCCTGGAGCCC
TGGCCCAGCCTCCCCGTGACACCCCACTCAGGAGCCCTGAGCCTGTGCAGTGCCGACACATCCCTGGGGGACAGGGCGGACACCTCGCTG
CCACAGACCCAGGGGCCGGGGCTGCTTTGTTCCCCAGGCGTGTCTGCAGCAGCGCTGGCACTGCAGTGGGCCGAGTCTCCGCCGGCTGAC
GACCACCATGTGCAGAGGACGGCTGTGGAGAAAGATGTCGAAGATTTTATCACAACATCCTTTGATTCTCAAGAAACATTAAGTTCACCT
CCTCCTGGATTAGAAGGAAAAGCTGATAGAAGTGAGAAAAGTGACGGCTCGGGTTTTGGAGCAAGACTGAGCCCGGGGTCAGGAGGCCCT
GAGGCTCAAACTGCTGGTCCTGTGACCCCTGCTTCCATCTCTGGAAGGTTTCAGCCGCTGCCGGAAGCCATGAAGGAGAAGGAAGTGCGT
CCGAAGCACGTGAAGGCTTTACTGCAGATGGTGCGTGACGAGAGCCACCAGATCCTGGCGCTGTCAGAAGGCCTTGCACCCCCAAGCGGC
GAGCCACACCCACCCCGGAAGGAAGACGAGATACAGGACATCTCGCTCCATGGGGGAAAGACGCAGGAAGTGCCCACCGCGTGCCCCGAT
TGGAGAGGGGACCTTCTGCAGGTTGTGCAAGAGGCCTTTGAAAAAGAGCAGGAGATGCAGGGGGTTGAGCTGCAGCCCCGACTCAGTGGC
TCAGATCTGGGGGGTCACAGCTCCCTGCTCGAAAGGCTGGAGAAGATCATCCGTGAGCAGGGAGACCTGCAGGAAAAGTCCCTGGAGCAT
CTTCGCTTGCCGGACCGGAGCAGCCTGCTGTCCGAGATCCAGGCGCTGCGTGCCCAGCTGCGCATGACGCACCTGCAGAACCAGGAGAAG
CTGCAGCACTTGCGCACGGCGCTGACAAGCGCAGAGGCGCGCGGGAGCCAGCAGGAGCACCAGCTGCGCAGGCAGGTTGAACTGCTGGCT
TATAAAGTAGAGCAGGAGAAGTGCATTGCTGGTGACTTGCAGAAGACGCTGAGTGAAGAGCAAGAGAAGGCAAACAGCGTGCAGAAGCTC
CTGGCGGCGGAGCAGACTGTAGTGCGAGATTTGAAGTCCGACCTCTGTGAGAGCAGGCAGAAGAGCGAACAGCTGTCCCGGTCCCTCTGC
GAGGTGCAGCAGGAGGTCCTCCAGCTGAGATCCATGCTGAGCAGTAAGGAGAACGAGCTGAAGGCCGCGCTTCAGGAGCTGGAGAGTGAG
CAGGGGAAGGGGCGTGCCCTGCAGAGCCAGCTGGAGGAGGAGCAGCTGCGGCACCTGCAGAGGGAGAGCCAGAGTGCCAAGGCCCTGGAG
GAGCTGCGGGCGTCTTTGGAGACACAGCGTGCTCAGAGCAGTCGACTCTGCGTGGCACTGAAACACGAGCAGACGGCCAAGGACAACCTG
CAGAAGGAGCTGCGTATCGAGCACTCACGCTGCGAGGCCTTGCTGGCTCAGGAGCGGAGCCAGCTCTCTGAGCTCCAGAAGGACCTTGCG
GCTGAGAAGAGCCGCACCCTGGAGCTGTCAGAGGCCTTGCGGCACGAGCGGCTCCTGACCGAGCAGCTGAGCCAGAGGACACAGGAGGCT
TGCGTGCACCAGGACACACAGGCCCATCACGCTCTGCTGCAGAAGCTGAAGGAGGAGAAGTCCCGGGTGGTGGACTTGCAAGCGATGCTT
GAAAAGGTGCAGCAGCAAGCCCTGCATTCTCAGCAGCAGCTTGAGGCTGAGGCTCAGAAGCACTGTGAGGCGCTCAGGAGAGAGAAGGAG
GTAAGTGCCACACTGAAGTCGACGGTGGAAGCCCTGCACACCCAAAAACGAGAGCTGAGATGCTCTCTGGAGAGAGAGAGGGAGAAACCA
GCGTGGTTGCAGGCAGAATTAGAGCAGTCACACCCACGGTTGAAAGAGCAAGAAGGACGCAAGGCTGCGAGGAGGAGCGCGGAGGCCAGG
CAGAGCCCAGCGGCTGCGGAGCAGTGGAGGAAGTGGCAGAGAGACAAGGAGAAGCTGCGAGAATTAGAACTGCAGCGTCAGCGTGACTTG
CATAAGATCAAGCAGCTTCAGCAGACAGTGAGAGACCTGGAGTCGAAGGACGAGGTGCCTGGCAGCCGCCTCCACCTAGGTTCTGCCCGC
AGGGCTGCCGGCTCGGATGCGGACCACCTCCGGGAACAGCAGCGAGAGCTGGAGGCGATGAGGCAGCGGCTGCTCTCTGCCGCCCGGCTT
CTCACCAGCTTCACCAGCCAGGCCGTGGACAGGACAGTTAATGATTGGACGTCATCCAATGAGAAAGCAGTGATGTCTTTACTGCACACG
TTGGAGGAGCTGAAGTCTGACTTGAGCAGGCCCACCTCCTCCCAGAAAAAAATGGCAGCAGAGCTGCAGTTCCAGTTTGTGGACGTCCTG
CTGAAAGACAATGTTTCCCTCACAAAAGCGCTCAGCACGGTGACCCAGGAGAAGCTGGAGCTGAGCAGAGCCGTGTCTAAGCTTGAGAAG
TTGCTGAAGCACCATCTGCAGAAGGGCTGCAGCCCAAGCAGGTCGGAAAGGTCTGCTTGGAAGCCAGACGAAACGGCTCCACAGAGTTCC
CTGAGGCGCCCAGACCCCGGCCGGCTTCCACCAGCTGCCAGCGAGGAAGCACACACCAGCAATGTCAAGATGGAAAAATTGTACCTGCAT
TACTTGAGAGCAGAGAGCTTTAGAAAAGCTCTGATTTATCAAAAGAAGTATCTTTTGCTGTTGATTGGTGGATTCCAGGATTCTGAACAA
GAAACACTCTCCATGATTGCCCATTTGGGGGTATTTCCTTCCAAAGCAGAACGGAAAATCACATCTCGTCCTTTCACCAGGTTCCGCACG
GCCGTCAGGGTGGTCATTGCAATATTAAGATTACGTTTTTTGGTTAAGAAATGGCAAGAAGTAGATCGGAAAGGAGCTCTGGCACAAGGC
AAAGCCCCTCGCCCAGGGCCCCGAGCACGACAGCCGCAGTCTCCACCCAGAACCAGAGAGTCCCCCCCAACCCGGGATGTACCCTCTGGC
CACACCAGGGACCCTGCCAGAGGCCGCAGACTGGCAGCAGCAGCCTCCCCACACAGTGGGGGAAGAGCCACTCCATCCCCAAATTCAAGA
TTAGAAAGATCCCTGACTGCTTCTCAAGATCCAGAACATTCCTTGACAGAGTATATTCACCATTTAGAAGTGATCCAGCAAAGATTGGGA
GGGGTACTACCAGATTCTACTTCAAAGAAATCCTGCCACCCGATGATTAAACAGTGAATAAAATGTCATGGCTCTTTCCTGCGACAATTC
TATTTGAGGAAAAGATTTGTTTTTCCCTTTTCCCAAGGAAGCTCGTGGGACAGCATGGGCACTACTCTTCATGTGCGGTGACACCAGCCC
CCAGATGCCTTGAATTAAGTGTCCTCACCTTTATGCATGACTGCAAAGCCAGCTGGAGCATTTTCTATGGAGCCTCCGTATGTTTTAGGC
CCATGACCTTCGTGAGGTGACGGGCACTCACTCCCATGAGCCCTGGCTGTGTGCTGTTGTGTGCCTATCGGCAGATCCATCCTTCCTGCC
TCCAAGGAGGATACACAGAGAATGGCTTCCTGTTGTTTTGTTTATTTTCTTAACGTGTACAGATGGAAACTTCATTTAAAAATAAAAACA

>78529_78529_3_RTFDC1-PCNT_RTFDC1_chr20_55049827_ENST00000395881_PCNT_chr21_47817928_ENST00000359568_length(amino acids)=1940AA_BP=86
MGCDGGTIPKRHELVKGPKKVEKVDKDAELVAQWNYCTLSQEILRRPIVACELGRLYNKDAVIEFLLDKSAEKALGKAASHIKSIKEQAA
EREHEREEFQQEIQRLEGQLRQAAKPQPWGPRDSQQAPLDGEVELLQQKLREKLDEFNELAIQKESADRQVLMQEEEIKRLEEMNINIRK
KVAQLQEEVEKQKNIVKGLEQDKEVLKKQQMSSLLLASTLQSTLDAGRCPEPPSGSPPEGPEIQLEVTQRALLRRESEVLDLKEQLEKMK
GDLESKNEEILHLNLKLDMQNSQTAVSLRELEEENTSLKVIYTRSSEIEELKATIENLQENQKRLQKEKAEEIEQLHEVIEKLQHELSLM
GPVVHEVSDSQAGSLQSELLCSQAGGPRGQALQGELEAALEAKEALSRLLADQERRHSQALEALQQRLQGAEEAAELQLAELERNVALRE
AEVEDMASRIQEFEAALKAKEATIAERNLEIDALNQRKAAHSAELEAVLLALARIRRALEQQPLAAGAAPPELQWLRAQCARLSRQLQVL
HQRFLRCQVELDRRQARRATAHTRVPGAHPQPRMDGGAKAQVTGDVEASHDAALEPVVPDPQGDLQPVLVTLKDAPLCKQEGVMSVLTVC
QRQLQSELLLVKNEMRLSLEDGGKGKEKVLEDCQLPKVDLVAQVKQLQEKLNRLLYSMTFQNVDAADTKSLWPMASAHLLESSWSDDSCD
GEEPDISPHIDTCDANTATGGVTDVIKNQAIDACDANTTPGGVTDVIKNWDSLIPDEMPDSPIQEKSECQDMSLSSPTSVLGGSRHQSHT
AEAGPRKSPVGMLDLSSWSSPEVLRKDWTLEPWPSLPVTPHSGALSLCSADTSLGDRADTSLPQTQGPGLLCSPGVSAAALALQWAESPP
ADDHHVQRTAVEKDVEDFITTSFDSQETLSSPPPGLEGKADRSEKSDGSGFGARLSPGSGGPEAQTAGPVTPASISGRFQPLPEAMKEKE
VRPKHVKALLQMVRDESHQILALSEGLAPPSGEPHPPRKEDEIQDISLHGGKTQEVPTACPDWRGDLLQVVQEAFEKEQEMQGVELQPRL
SGSDLGGHSSLLERLEKIIREQGDLQEKSLEHLRLPDRSSLLSEIQALRAQLRMTHLQNQEKLQHLRTALTSAEARGSQQEHQLRRQVEL
LAYKVEQEKCIAGDLQKTLSEEQEKANSVQKLLAAEQTVVRDLKSDLCESRQKSEQLSRSLCEVQQEVLQLRSMLSSKENELKAALQELE
SEQGKGRALQSQLEEEQLRHLQRESQSAKALEELRASLETQRAQSSRLCVALKHEQTAKDNLQKELRIEHSRCEALLAQERSQLSELQKD
LAAEKSRTLELSEALRHERLLTEQLSQRTQEACVHQDTQAHHALLQKLKEEKSRVVDLQAMLEKVQQQALHSQQQLEAEAQKHCEALRRE
KEVSATLKSTVEALHTQKRELRCSLEREREKPAWLQAELEQSHPRLKEQEGRKAARRSAEARQSPAAAEQWRKWQRDKEKLRELELQRQR
DLHKIKQLQQTVRDLESKDEVPGSRLHLGSARRAAGSDADHLREQQRELEAMRQRLLSAARLLTSFTSQAVDRTVNDWTSSNEKAVMSLL
HTLEELKSDLSRPTSSQKKMAAELQFQFVDVLLKDNVSLTKALSTVTQEKLELSRAVSKLEKLLKHHLQKGCSPSRSERSAWKPDETAPQ
SSLRRPDPGRLPPAASEEAHTSNVKMEKLYLHYLRAESFRKALIYQKKYLLLLIGGFQDSEQETLSMIAHLGVFPSKAERKITSRPFTRF
RTAVRVVIAILRLRFLVKKWQEVDRKGALAQGKAPRPGPRARQPQSPPRTRESPPTRDVPSGHTRDPARGRRLAAAASPHSGGRATPSPN

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Fusion Gene PPI Analysis for RTFDC1-PCNT


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
TgenePCNTchr20:55049827chr21:47817928ENST0000035956821472983_32461482.03337.0NEK2


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for RTFDC1-PCNT


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for RTFDC1-PCNT


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource