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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:RTN4-TMEM66 (FusionGDB2 ID:78595)

Fusion Gene Summary for RTN4-TMEM66

check button Fusion gene summary
Fusion gene informationFusion gene name: RTN4-TMEM66
Fusion gene ID: 78595
HgeneTgene
Gene symbol

RTN4

TMEM66

Gene ID

57142

51669

Gene namereticulon 4store-operated calcium entry associated regulatory factor
SynonymsASY|NI220/250|NOGO|NSP|NSP-CL|Nbla00271|Nbla10545|RTN-X|RTN4-A|RTN4-B1|RTN4-B2|RTN4-CFOAP-7|HSPC035|TMEM66|XTP3
Cytomap

2p16.1

8p12

Type of geneprotein-codingprotein-coding
Descriptionreticulon-4Human NogoAMy043 proteinfoocenneurite growth inhibitor 220neurite outgrowth inhibitorneuroendocrine-specific protein C homologreticulon 5store-operated calcium entry-associated regulatory factorHBV X-transactivated gene 3 proteinHBV XAg-transactivated protein 3SARAF long isoformSARAF short isoformSOCE-associated regulatory factortesticular secretory protein Li 59transmembrane protei
Modification date2020032720200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000317610, ENST00000337526, 
ENST00000354474, ENST00000357376, 
ENST00000357732, ENST00000394609, 
ENST00000394611, ENST00000402434, 
ENST00000404909, ENST00000405240, 
ENST00000486085, 
ENST00000536273, 
ENST00000545648, ENST00000521083, 
ENST00000256255, 
Fusion gene scores* DoF score18 X 22 X 7=27725 X 3 X 3=45
# samples 275
** MAII scorelog2(27/2772*10)=-3.35989594508638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(5/45*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: RTN4 [Title/Abstract] AND TMEM66 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointRTN4(55209650)-TMEM66(29927575), # samples:1
Anticipated loss of major functional domain due to fusion event.RTN4-TMEM66 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
RTN4-TMEM66 seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneRTN4

GO:0030517

negative regulation of axon extension

10667797

HgeneRTN4

GO:0071787

endoplasmic reticulum tubular network formation

24262037|25612671

HgeneRTN4

GO:1905552

positive regulation of protein localization to endoplasmic reticulum

27353365

TgeneTMEM66

GO:2001256

regulation of store-operated calcium entry

22464749


check buttonFusion gene breakpoints across RTN4 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across TMEM66 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4Non-CancerTCGA-BC-A10Z-11ARTN4chr2

55209650

-TMEM66chr8

29927575

-


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Fusion Gene ORF analysis for RTN4-TMEM66

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000317610ENST00000536273RTN4chr2

55209650

-TMEM66chr8

29927575

-
5CDS-5UTRENST00000317610ENST00000545648RTN4chr2

55209650

-TMEM66chr8

29927575

-
5CDS-5UTRENST00000337526ENST00000536273RTN4chr2

55209650

-TMEM66chr8

29927575

-
5CDS-5UTRENST00000337526ENST00000545648RTN4chr2

55209650

-TMEM66chr8

29927575

-
5CDS-5UTRENST00000354474ENST00000536273RTN4chr2

55209650

-TMEM66chr8

29927575

-
5CDS-5UTRENST00000354474ENST00000545648RTN4chr2

55209650

-TMEM66chr8

29927575

-
5CDS-5UTRENST00000357376ENST00000536273RTN4chr2

55209650

-TMEM66chr8

29927575

-
5CDS-5UTRENST00000357376ENST00000545648RTN4chr2

55209650

-TMEM66chr8

29927575

-
5CDS-5UTRENST00000357732ENST00000536273RTN4chr2

55209650

-TMEM66chr8

29927575

-
5CDS-5UTRENST00000357732ENST00000545648RTN4chr2

55209650

-TMEM66chr8

29927575

-
5CDS-5UTRENST00000394609ENST00000536273RTN4chr2

55209650

-TMEM66chr8

29927575

-
5CDS-5UTRENST00000394609ENST00000545648RTN4chr2

55209650

-TMEM66chr8

29927575

-
5CDS-5UTRENST00000394611ENST00000536273RTN4chr2

55209650

-TMEM66chr8

29927575

-
5CDS-5UTRENST00000394611ENST00000545648RTN4chr2

55209650

-TMEM66chr8

29927575

-
5CDS-5UTRENST00000402434ENST00000536273RTN4chr2

55209650

-TMEM66chr8

29927575

-
5CDS-5UTRENST00000402434ENST00000545648RTN4chr2

55209650

-TMEM66chr8

29927575

-
5CDS-5UTRENST00000404909ENST00000536273RTN4chr2

55209650

-TMEM66chr8

29927575

-
5CDS-5UTRENST00000404909ENST00000545648RTN4chr2

55209650

-TMEM66chr8

29927575

-
5CDS-5UTRENST00000405240ENST00000536273RTN4chr2

55209650

-TMEM66chr8

29927575

-
5CDS-5UTRENST00000405240ENST00000545648RTN4chr2

55209650

-TMEM66chr8

29927575

-
5CDS-intronENST00000317610ENST00000521083RTN4chr2

55209650

-TMEM66chr8

29927575

-
5CDS-intronENST00000337526ENST00000521083RTN4chr2

55209650

-TMEM66chr8

29927575

-
5CDS-intronENST00000354474ENST00000521083RTN4chr2

55209650

-TMEM66chr8

29927575

-
5CDS-intronENST00000357376ENST00000521083RTN4chr2

55209650

-TMEM66chr8

29927575

-
5CDS-intronENST00000357732ENST00000521083RTN4chr2

55209650

-TMEM66chr8

29927575

-
5CDS-intronENST00000394609ENST00000521083RTN4chr2

55209650

-TMEM66chr8

29927575

-
5CDS-intronENST00000394611ENST00000521083RTN4chr2

55209650

-TMEM66chr8

29927575

-
5CDS-intronENST00000402434ENST00000521083RTN4chr2

55209650

-TMEM66chr8

29927575

-
5CDS-intronENST00000404909ENST00000521083RTN4chr2

55209650

-TMEM66chr8

29927575

-
5CDS-intronENST00000405240ENST00000521083RTN4chr2

55209650

-TMEM66chr8

29927575

-
5UTR-3CDSENST00000486085ENST00000256255RTN4chr2

55209650

-TMEM66chr8

29927575

-
5UTR-5UTRENST00000486085ENST00000536273RTN4chr2

55209650

-TMEM66chr8

29927575

-
5UTR-5UTRENST00000486085ENST00000545648RTN4chr2

55209650

-TMEM66chr8

29927575

-
5UTR-intronENST00000486085ENST00000521083RTN4chr2

55209650

-TMEM66chr8

29927575

-
Frame-shiftENST00000357376ENST00000256255RTN4chr2

55209650

-TMEM66chr8

29927575

-
Frame-shiftENST00000394611ENST00000256255RTN4chr2

55209650

-TMEM66chr8

29927575

-
Frame-shiftENST00000404909ENST00000256255RTN4chr2

55209650

-TMEM66chr8

29927575

-
Frame-shiftENST00000405240ENST00000256255RTN4chr2

55209650

-TMEM66chr8

29927575

-
In-frameENST00000317610ENST00000256255RTN4chr2

55209650

-TMEM66chr8

29927575

-
In-frameENST00000337526ENST00000256255RTN4chr2

55209650

-TMEM66chr8

29927575

-
In-frameENST00000354474ENST00000256255RTN4chr2

55209650

-TMEM66chr8

29927575

-
In-frameENST00000357732ENST00000256255RTN4chr2

55209650

-TMEM66chr8

29927575

-
In-frameENST00000394609ENST00000256255RTN4chr2

55209650

-TMEM66chr8

29927575

-
In-frameENST00000402434ENST00000256255RTN4chr2

55209650

-TMEM66chr8

29927575

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000394609RTN4chr255209650-ENST00000256255TMEM66chr829927575-23247103291447372
ENST00000317610RTN4chr255209650-ENST00000256255TMEM66chr829927575-276111472171884555
ENST00000357732RTN4chr255209650-ENST00000256255TMEM66chr829927575-281812042171941574
ENST00000337526RTN4chr255209650-ENST00000256255TMEM66chr829927575-5218360421743411374
ENST00000354474RTN4chr255209650-ENST00000256255TMEM66chr829927575-42782664034011133
ENST00000402434RTN4chr255209650-ENST00000256255TMEM66chr829927575-2509895491632527

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000394609ENST00000256255RTN4chr255209650-TMEM66chr829927575-0.0003908560.9996092
ENST00000317610ENST00000256255RTN4chr255209650-TMEM66chr829927575-0.0006286670.99937135
ENST00000357732ENST00000256255RTN4chr255209650-TMEM66chr829927575-0.0007072180.99929273
ENST00000337526ENST00000256255RTN4chr255209650-TMEM66chr829927575-0.0004681390.99953187
ENST00000354474ENST00000256255RTN4chr255209650-TMEM66chr829927575-0.0002842090.99971575
ENST00000402434ENST00000256255RTN4chr255209650-TMEM66chr829927575-0.0010710660.99892896

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Fusion Genomic Features for RTN4-TMEM66


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for RTN4-TMEM66


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:55209650/chr8:29927575)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneRTN4chr2:55209650chr8:29927575ENST00000317610-37143_148301374.0Compositional biasNote=Poly-Pro
HgeneRTN4chr2:55209650chr8:29927575ENST00000317610-3730_47301374.0Compositional biasNote=Poly-Glu
HgeneRTN4chr2:55209650chr8:29927575ENST00000337526-59143_14811201193.0Compositional biasNote=Poly-Pro
HgeneRTN4chr2:55209650chr8:29927575ENST00000337526-5930_4711201193.0Compositional biasNote=Poly-Glu
HgeneRTN4chr2:55209650chr8:29927575ENST00000357376-59143_148914987.0Compositional biasNote=Poly-Pro
HgeneRTN4chr2:55209650chr8:29927575ENST00000357376-5930_47914987.0Compositional biasNote=Poly-Glu
HgeneRTN4chr2:55209650chr8:29927575ENST00000357732-48143_148320393.0Compositional biasNote=Poly-Pro
HgeneRTN4chr2:55209650chr8:29927575ENST00000357732-4830_47320393.0Compositional biasNote=Poly-Glu
HgeneRTN4chr2:55209650chr8:29927575ENST00000394609-3730_47127200.0Compositional biasNote=Poly-Glu
HgeneRTN4chr2:55209650chr8:29927575ENST00000394611-59143_148914987.0Compositional biasNote=Poly-Pro
HgeneRTN4chr2:55209650chr8:29927575ENST00000394611-5930_47914987.0Compositional biasNote=Poly-Glu
HgeneRTN4chr2:55209650chr8:29927575ENST00000404909-59143_148914987.0Compositional biasNote=Poly-Pro
HgeneRTN4chr2:55209650chr8:29927575ENST00000404909-5930_47914987.0Compositional biasNote=Poly-Glu
HgeneRTN4chr2:55209650chr8:29927575ENST00000405240-59143_148914987.0Compositional biasNote=Poly-Pro
HgeneRTN4chr2:55209650chr8:29927575ENST00000405240-5930_47914987.0Compositional biasNote=Poly-Glu
HgeneRTN4chr2:55209650chr8:29927575ENST00000337526-591_101811201193.0Topological domainCytoplasmic
HgeneRTN4chr2:55209650chr8:29927575ENST00000337526-591019_103911201193.0TransmembraneHelical
TgeneTMEM66chr2:55209650chr8:29927575ENST0000025625516195_33994340.0Topological domainCytoplasmic
TgeneTMEM66chr2:55209650chr8:29927575ENST0000053627305195_3390168.0Topological domainCytoplasmic
TgeneTMEM66chr2:55209650chr8:29927575ENST000005362730531_1730168.0Topological domainLumenal
TgeneTMEM66chr2:55209650chr8:29927575ENST0000054564827195_3390168.0Topological domainCytoplasmic
TgeneTMEM66chr2:55209650chr8:29927575ENST000005456482731_1730168.0Topological domainLumenal
TgeneTMEM66chr2:55209650chr8:29927575ENST0000025625516174_19494340.0TransmembraneHelical
TgeneTMEM66chr2:55209650chr8:29927575ENST0000053627305174_1940168.0TransmembraneHelical
TgeneTMEM66chr2:55209650chr8:29927575ENST0000054564827174_1940168.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneRTN4chr2:55209650chr8:29927575ENST00000394609-37143_148127200.0Compositional biasNote=Poly-Pro
HgeneRTN4chr2:55209650chr8:29927575ENST00000317610-371005_1192301374.0DomainReticulon
HgeneRTN4chr2:55209650chr8:29927575ENST00000337526-591005_119211201193.0DomainReticulon
HgeneRTN4chr2:55209650chr8:29927575ENST00000357376-591005_1192914987.0DomainReticulon
HgeneRTN4chr2:55209650chr8:29927575ENST00000357732-481005_1192320393.0DomainReticulon
HgeneRTN4chr2:55209650chr8:29927575ENST00000394609-371005_1192127200.0DomainReticulon
HgeneRTN4chr2:55209650chr8:29927575ENST00000394611-591005_1192914987.0DomainReticulon
HgeneRTN4chr2:55209650chr8:29927575ENST00000404909-591005_1192914987.0DomainReticulon
HgeneRTN4chr2:55209650chr8:29927575ENST00000405240-591005_1192914987.0DomainReticulon
HgeneRTN4chr2:55209650chr8:29927575ENST00000317610-371040_1133301374.0Topological domainLumenal
HgeneRTN4chr2:55209650chr8:29927575ENST00000317610-371155_1192301374.0Topological domainCytoplasmic
HgeneRTN4chr2:55209650chr8:29927575ENST00000317610-371_1018301374.0Topological domainCytoplasmic
HgeneRTN4chr2:55209650chr8:29927575ENST00000337526-591040_113311201193.0Topological domainLumenal
HgeneRTN4chr2:55209650chr8:29927575ENST00000337526-591155_119211201193.0Topological domainCytoplasmic
HgeneRTN4chr2:55209650chr8:29927575ENST00000357376-591040_1133914987.0Topological domainLumenal
HgeneRTN4chr2:55209650chr8:29927575ENST00000357376-591155_1192914987.0Topological domainCytoplasmic
HgeneRTN4chr2:55209650chr8:29927575ENST00000357376-591_1018914987.0Topological domainCytoplasmic
HgeneRTN4chr2:55209650chr8:29927575ENST00000357732-481040_1133320393.0Topological domainLumenal
HgeneRTN4chr2:55209650chr8:29927575ENST00000357732-481155_1192320393.0Topological domainCytoplasmic
HgeneRTN4chr2:55209650chr8:29927575ENST00000357732-481_1018320393.0Topological domainCytoplasmic
HgeneRTN4chr2:55209650chr8:29927575ENST00000394609-371040_1133127200.0Topological domainLumenal
HgeneRTN4chr2:55209650chr8:29927575ENST00000394609-371155_1192127200.0Topological domainCytoplasmic
HgeneRTN4chr2:55209650chr8:29927575ENST00000394609-371_1018127200.0Topological domainCytoplasmic
HgeneRTN4chr2:55209650chr8:29927575ENST00000394611-591040_1133914987.0Topological domainLumenal
HgeneRTN4chr2:55209650chr8:29927575ENST00000394611-591155_1192914987.0Topological domainCytoplasmic
HgeneRTN4chr2:55209650chr8:29927575ENST00000394611-591_1018914987.0Topological domainCytoplasmic
HgeneRTN4chr2:55209650chr8:29927575ENST00000404909-591040_1133914987.0Topological domainLumenal
HgeneRTN4chr2:55209650chr8:29927575ENST00000404909-591155_1192914987.0Topological domainCytoplasmic
HgeneRTN4chr2:55209650chr8:29927575ENST00000404909-591_1018914987.0Topological domainCytoplasmic
HgeneRTN4chr2:55209650chr8:29927575ENST00000405240-591040_1133914987.0Topological domainLumenal
HgeneRTN4chr2:55209650chr8:29927575ENST00000405240-591155_1192914987.0Topological domainCytoplasmic
HgeneRTN4chr2:55209650chr8:29927575ENST00000405240-591_1018914987.0Topological domainCytoplasmic
HgeneRTN4chr2:55209650chr8:29927575ENST00000317610-371019_1039301374.0TransmembraneHelical
HgeneRTN4chr2:55209650chr8:29927575ENST00000317610-371134_1154301374.0TransmembraneHelical
HgeneRTN4chr2:55209650chr8:29927575ENST00000337526-591134_115411201193.0TransmembraneHelical
HgeneRTN4chr2:55209650chr8:29927575ENST00000357376-591019_1039914987.0TransmembraneHelical
HgeneRTN4chr2:55209650chr8:29927575ENST00000357376-591134_1154914987.0TransmembraneHelical
HgeneRTN4chr2:55209650chr8:29927575ENST00000357732-481019_1039320393.0TransmembraneHelical
HgeneRTN4chr2:55209650chr8:29927575ENST00000357732-481134_1154320393.0TransmembraneHelical
HgeneRTN4chr2:55209650chr8:29927575ENST00000394609-371019_1039127200.0TransmembraneHelical
HgeneRTN4chr2:55209650chr8:29927575ENST00000394609-371134_1154127200.0TransmembraneHelical
HgeneRTN4chr2:55209650chr8:29927575ENST00000394611-591019_1039914987.0TransmembraneHelical
HgeneRTN4chr2:55209650chr8:29927575ENST00000394611-591134_1154914987.0TransmembraneHelical
HgeneRTN4chr2:55209650chr8:29927575ENST00000404909-591019_1039914987.0TransmembraneHelical
HgeneRTN4chr2:55209650chr8:29927575ENST00000404909-591134_1154914987.0TransmembraneHelical
HgeneRTN4chr2:55209650chr8:29927575ENST00000405240-591019_1039914987.0TransmembraneHelical
HgeneRTN4chr2:55209650chr8:29927575ENST00000405240-591134_1154914987.0TransmembraneHelical
TgeneTMEM66chr2:55209650chr8:29927575ENST000002562551631_17394340.0Topological domainLumenal


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Fusion Gene Sequence for RTN4-TMEM66


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>78595_78595_1_RTN4-TMEM66_RTN4_chr2_55209650_ENST00000317610_TMEM66_chr8_29927575_ENST00000256255_length(transcript)=2761nt_BP=1147nt
GCTGGCCTCACTCCTAGCTCATCTGGGCGGCGGCGGCAAGTGGGGACAGGGCGGGTGGCGCATCACCGGCGCGGAGGCAGGAGGAGCAGT
CTCATTGTTCCGGGAGCCGTCACCACAGTAGGTCCCTCGGCTCAGTCGGCCCAGCCCCTCTCAGTCCTCCCCAACCCCCACAACCGCCCG
CGGCTCTGAGACGCGGCCCCGGCGGCGGCGGCAGCAGCTGCAGCATCATCTCCACCCTCCAGCCATGGAAGACCTGGACCAGTCTCCTCT
GGTCTCGTCCTCGGACAGCCCACCCCGGCCGCAGCCCGCGTTCAAGTACCAGTTCGTGAGGGAGCCCGAGGACGAGGAGGAAGAAGAGGA
GGAGGAAGAGGAGGACGAGGACGAAGACCTGGAGGAGCTGGAGGTGCTGGAGAGGAAGCCCGCCGCCGGGCTGTCCGCGGCCCCAGTGCC
CACCGCCCCTGCCGCCGGCGCGCCCCTGATGGACTTCGGAAATGACTTCGTGCCGCCGGCGCCCCGGGGACCCCTGCCGGCCGCTCCCCC
CGTCGCCCCGGAGCGGCAGCCGTCTTGGGACCCGAGCCCGGTGTCGTCGACCGTGCCCGCGCCATCCCCGCTGTCTGCTGCCGCAGTCTC
GCCCTCCAAGCTCCCTGAGGACGACGAGCCTCCGGCCCGGCCTCCCCCTCCTCCCCCGGCCAGCGTGAGCCCCCAGGCAGAGCCCGTGTG
GACCCCGCCAGCCCCGGCTCCCGCCGCGCCCCCCTCCACCCCGGCCGCGCCCAAGCGCAGGGGCTCCTCGGGCTCAGTGGTTGTTGACCT
CCTGTACTGGAGAGACATTAAGAAGACTGGAGTGGTGTTTGGTGCCAGCCTATTCCTGCTGCTTTCATTGACAGTATTCAGCATTGTGAG
CGTAACAGCCTACATTGCCTTGGCCCTGCTCTCTGTGACCATCAGCTTTAGGATATACAAGGGTGTGATCCAAGCTATCCAGAAATCAGA
TGAAGGCCACCCATTCAGGGCATATCTGGAATCTGAAGTTGCTATATCTGAGGAGTTGGTTCAGAAGTACAGTAATTCTGCTCTTGGTCA
TGTGAACTGCACGATAAAGGAACTCAGGCGCCTCTTCTTAGTTGATGATTTAGTTGATTCTCTGAAGTGGGAATGTAAGACGGACTTAGA
TATTGCATACAAATTTGGAAAAACTGTGGTGAGCTGTGAAGGCTATGAGTCCTCTGAAGACCAGTATGTACTAAGAGGTTCTTGTGGCTT
GGAGTATAATTTAGATTATACAGAACTTGGCCTGCAGAAACTGAAGGAGTCTGGAAAGCAGCACGGCTTTGCCTCTTTCTCTGATTATTA
TTATAAGTGGTCCTCGGCGGATTCCTGTAACATGAGTGGATTGATTACCATTGTGGTACTCCTTGGGATCGCGTTTGTAGTCTATAAGCT
GTTCCTGAGTGACGGGCAGTATTCTCCTCCACCGTACTCTGAGTATCCTCCATTTTCCCACCGTTACCAGAGATTCACCAACTCAGCAGG
ACCTCCTCCCCCAGGCTTTAAGTCTGAGTTCACAGGACCACAGAATACTGGCCATGGTGCAACTTCTGGTTTTGGCAGTGCTTTTACAGG
ACAACAAGGATATGAAAATTCAGGACCAGGGTTCTGGACAGGCTTGGGAACTGGTGGAATACTAGGATATTTGTTTGGCAGCAATAGAGC
GGCAACACCCTTCTCAGACTCGTGGTACTACCCGTCCTATCCTCCCTCCTACCCTGGCACGTGGAATAGGGCTTACTCACCCCTTCATGG
AGGCTCGGGCAGCTATTCGGTATGTTCAAACTCAGACACGAAAACCAGAACTGCATCAGGATATGGTGGTACCAGGAGACGATAAAGTAG
AAAGTTGGAGTCAAACACTGGATGCAGAAATTTTGGATTTTTCATCACTTTCTCTTTAGAAAAAAAGTACTACCTGTTAACAATTGGGAA
AAGGGGATATTCAAAAGTTCTGTGGTGTTATGTCCAGTGTAGCTTTTTGTATTCTATTATTTGAGGCTAAAAGTTGATGTGTGACAAAAT
ACTTATGTGTTGTATGTCAGTGTAACATGCAGATGTATATTGCAGTTTTTGAAAGTGATCATTACTGTGGAATGCTAAAAATACATTAAT
TTCTAAAACCTGTGATGCCCTAAGAAGCATTAAGAATGAAGGTGTTGTACTAATAGAAACTAAGTACAGAAAATTTCAGTTTTAGGTGGT
TGTAGCTGATGAGTTATTACCTCATAGAGACTATAATATTCTATTTGGTATTATATTATTTGATGTTTGCTGTTCTTCAAACATTTAAAT
CAAGCTTTGGACTAATTATGCTAATTTGTGAGTTCTGATCACTTTTGAGCTCTGAAGCTTTGAATCATTCAGTGGTGGAGATGGCCTTCT
GGTAACTGAATATTACCTTCTGTAGGAAAAGGTAGAAAATAAGCATCTAGAAGGTTGTTGTGAATGACTCTGTGCTGGCAAAAATGCTTG
AAACCTCTATATTTCTTTCGTTCATAAGAGGTAAAGGTCAAATTTTTCAACAAAAGTCTTTTAATAACAAAAGCATGCAGTTCTCTGTGA
AATCTCAAATATTGTTGTAATAGTCTGTTTCAATCTTAAAAAGAATCAATAAAAACAAACAAGGGGTTTAGTCTCATTCTTTCTATTAGC

>78595_78595_1_RTN4-TMEM66_RTN4_chr2_55209650_ENST00000317610_TMEM66_chr8_29927575_ENST00000256255_length(amino acids)=555AA_BP=310
MQHHLHPPAMEDLDQSPLVSSSDSPPRPQPAFKYQFVREPEDEEEEEEEEEEDEDEDLEELEVLERKPAAGLSAAPVPTAPAAGAPLMDF
GNDFVPPAPRGPLPAAPPVAPERQPSWDPSPVSSTVPAPSPLSAAAVSPSKLPEDDEPPARPPPPPPASVSPQAEPVWTPPAPAPAAPPS
TPAAPKRRGSSGSVVVDLLYWRDIKKTGVVFGASLFLLLSLTVFSIVSVTAYIALALLSVTISFRIYKGVIQAIQKSDEGHPFRAYLESE
VAISEELVQKYSNSALGHVNCTIKELRRLFLVDDLVDSLKWECKTDLDIAYKFGKTVVSCEGYESSEDQYVLRGSCGLEYNLDYTELGLQ
KLKESGKQHGFASFSDYYYKWSSADSCNMSGLITIVVLLGIAFVVYKLFLSDGQYSPPPYSEYPPFSHRYQRFTNSAGPPPPGFKSEFTG
PQNTGHGATSGFGSAFTGQQGYENSGPGFWTGLGTGGILGYLFGSNRAATPFSDSWYYPSYPPSYPGTWNRAYSPLHGGSGSYSVCSNSD

--------------------------------------------------------------
>78595_78595_2_RTN4-TMEM66_RTN4_chr2_55209650_ENST00000337526_TMEM66_chr8_29927575_ENST00000256255_length(transcript)=5218nt_BP=3604nt
GCTGGCCTCACTCCTAGCTCATCTGGGCGGCGGCGGCAAGTGGGGACAGGGCGGGTGGCGCATCACCGGCGCGGAGGCAGGAGGAGCAGT
CTCATTGTTCCGGGAGCCGTCACCACAGTAGGTCCCTCGGCTCAGTCGGCCCAGCCCCTCTCAGTCCTCCCCAACCCCCACAACCGCCCG
CGGCTCTGAGACGCGGCCCCGGCGGCGGCGGCAGCAGCTGCAGCATCATCTCCACCCTCCAGCCATGGAAGACCTGGACCAGTCTCCTCT
GGTCTCGTCCTCGGACAGCCCACCCCGGCCGCAGCCCGCGTTCAAGTACCAGTTCGTGAGGGAGCCCGAGGACGAGGAGGAAGAAGAGGA
GGAGGAAGAGGAGGACGAGGACGAAGACCTGGAGGAGCTGGAGGTGCTGGAGAGGAAGCCCGCCGCCGGGCTGTCCGCGGCCCCAGTGCC
CACCGCCCCTGCCGCCGGCGCGCCCCTGATGGACTTCGGAAATGACTTCGTGCCGCCGGCGCCCCGGGGACCCCTGCCGGCCGCTCCCCC
CGTCGCCCCGGAGCGGCAGCCGTCTTGGGACCCGAGCCCGGTGTCGTCGACCGTGCCCGCGCCATCCCCGCTGTCTGCTGCCGCAGTCTC
GCCCTCCAAGCTCCCTGAGGACGACGAGCCTCCGGCCCGGCCTCCCCCTCCTCCCCCGGCCAGCGTGAGCCCCCAGGCAGAGCCCGTGTG
GACCCCGCCAGCCCCGGCTCCCGCCGCGCCCCCCTCCACCCCGGCCGCGCCCAAGCGCAGGGGCTCCTCGGGCTCAGTGGATGAGACCCT
TTTTGCTCTTCCTGCTGCATCTGAGCCTGTGATACGCTCCTCTGCAGAAAATATGGACTTGAAGGAGCAGCCAGGTAACACTATTTCGGC
TGGTCAAGAGGATTTCCCATCTGTCCTGCTTGAAACTGCTGCTTCTCTTCCTTCTCTGTCTCCTCTCTCAGCCGCTTCTTTCAAAGAACA
TGAATACCTTGGTAATTTGTCAACAGTATTACCCACTGAAGGAACACTTCAAGAAAATGTCAGTGAAGCTTCTAAAGAGGTCTCAGAGAA
GGCAAAAACTCTACTCATAGATAGAGATTTAACAGAGTTTTCAGAATTAGAATACTCAGAAATGGGATCATCGTTCAGTGTCTCTCCAAA
AGCAGAATCTGCCGTAATAGTAGCAAATCCTAGGGAAGAAATAATCGTGAAAAATAAAGATGAAGAAGAGAAGTTAGTTAGTAATAACAT
CCTTCATAATCAACAAGAGTTACCTACAGCTCTTACTAAATTGGTTAAAGAGGATGAAGTTGTGTCTTCAGAAAAAGCAAAAGACAGTTT
TAATGAAAAGAGAGTTGCAGTGGAAGCTCCTATGAGGGAGGAATATGCAGACTTCAAACCATTTGAGCGAGTATGGGAAGTGAAAGATAG
TAAGGAAGATAGTGATATGTTGGCTGCTGGAGGTAAAATCGAGAGCAACTTGGAAAGTAAAGTGGATAAAAAATGTTTTGCAGATAGCCT
TGAGCAAACTAATCACGAAAAAGATAGTGAGAGTAGTAATGATGATACTTCTTTCCCCAGTACGCCAGAAGGTATAAAGGATCGTTCAGG
AGCATATATCACATGTGCTCCCTTTAACCCAGCAGCAACTGAGAGCATTGCAACAAACATTTTTCCTTTGTTAGGAGATCCTACTTCAGA
AAATAAGACCGATGAAAAAAAAATAGAAGAAAAGAAGGCCCAAATAGTAACAGAGAAGAATACTAGCACCAAAACATCAAACCCTTTTCT
TGTAGCAGCACAGGATTCTGAGACAGATTATGTCACAACAGATAATTTAACAAAGGTGACTGAGGAAGTCGTGGCAAACATGCCTGAAGG
CCTGACTCCAGATTTAGTACAGGAAGCATGTGAAAGTGAATTGAATGAAGTTACTGGTACAAAGATTGCTTATGAAACAAAAATGGACTT
GGTTCAAACATCAGAAGTTATGCAAGAGTCACTCTATCCTGCAGCACAGCTTTGCCCATCATTTGAAGAGTCAGAAGCTACTCCTTCACC
AGTTTTGCCTGACATTGTTATGGAAGCACCATTGAATTCTGCAGTTCCTAGTGCTGGTGCTTCCGTGATACAGCCCAGCTCATCACCATT
AGAAGCTTCTTCAGTTAATTATGAAAGCATAAAACATGAGCCTGAAAACCCCCCACCATATGAAGAGGCCATGAGTGTATCACTAAAAAA
AGTATCAGGAATAAAGGAAGAAATTAAAGAGCCTGAAAATATTAATGCAGCTCTTCAAGAAACAGAAGCTCCTTATATATCTATTGCATG
TGATTTAATTAAAGAAACAAAGCTTTCTGCTGAACCAGCTCCGGATTTCTCTGATTATTCAGAAATGGCAAAAGTTGAACAGCCAGTGCC
TGATCATTCTGAGCTAGTTGAAGATTCCTCACCTGATTCTGAACCAGTTGACTTATTTAGTGATGATTCAATACCTGACGTTCCACAAAA
ACAAGATGAAACTGTGATGCTTGTGAAAGAAAGTCTCACTGAGACTTCATTTGAGTCAATGATAGAATATGAAAATAAGGAAAAACTCAG
TGCTTTGCCACCTGAGGGAGGAAAGCCATATTTGGAATCTTTTAAGCTCAGTTTAGATAACACAAAAGATACCCTGTTACCTGATGAAGT
TTCAACATTGAGCAAAAAGGAGAAAATTCCTTTGCAGATGGAGGAGCTCAGTACTGCAGTTTATTCAAATGATGACTTATTTATTTCTAA
GGAAGCACAGATAAGAGAAACTGAAACGTTTTCAGATTCATCTCCAATTGAAATTATAGATGAGTTCCCTACATTGATCAGTTCTAAAAC
TGATTCATTTTCTAAATTAGCCAGGGAATATACTGACCTAGAAGTATCCCACAAAAGTGAAATTGCTAATGCCCCGGATGGAGCTGGGTC
ATTGCCTTGCACAGAATTGCCCCATGACCTTTCTTTGAAGAACATACAACCCAAAGTTGAAGAGAAAATCAGTTTCTCAGATGACTTTTC
TAAAAATGGGTCTGCTACATCAAAGGTGCTCTTATTGCCTCCAGATGTTTCTGCTTTGGCCACTCAAGCAGAGATAGAGAGCATAGTTAA
ACCCAAAGTTCTTGTGAAAGAAGCTGAGAAAAAACTTCCTTCCGATACAGAAAAAGAGGACAGATCACCATCTGCTATATTTTCAGCAGA
GCTGAGTAAAACTTCAGTTGTTGACCTCCTGTACTGGAGAGACATTAAGAAGACTGGAGTGGTGTTTGGTGCCAGCCTATTCCTGCTGCT
TTCATTGACAGTATTCAGCATTGTGAGCGTAACAGCCTACATTGCCTTGGCCCTGCTCTCTGTGACCATCAGCTTTAGGATATACAAGGG
TGTGATCCAAGCTATCCAGAAATCAGATGAAGGCCACCCATTCAGGGCATATCTGGAATCTGAAGTTGCTATATCTGAGGAGTTGGTTCA
GAAGTACAGTAATTCTGCTCTTGGTCATGTGAACTGCACGATAAAGGAACTCAGGCGCCTCTTCTTAGTTGATGATTTAGTTGATTCTCT
GAAGTGGGAATGTAAGACGGACTTAGATATTGCATACAAATTTGGAAAAACTGTGGTGAGCTGTGAAGGCTATGAGTCCTCTGAAGACCA
GTATGTACTAAGAGGTTCTTGTGGCTTGGAGTATAATTTAGATTATACAGAACTTGGCCTGCAGAAACTGAAGGAGTCTGGAAAGCAGCA
CGGCTTTGCCTCTTTCTCTGATTATTATTATAAGTGGTCCTCGGCGGATTCCTGTAACATGAGTGGATTGATTACCATTGTGGTACTCCT
TGGGATCGCGTTTGTAGTCTATAAGCTGTTCCTGAGTGACGGGCAGTATTCTCCTCCACCGTACTCTGAGTATCCTCCATTTTCCCACCG
TTACCAGAGATTCACCAACTCAGCAGGACCTCCTCCCCCAGGCTTTAAGTCTGAGTTCACAGGACCACAGAATACTGGCCATGGTGCAAC
TTCTGGTTTTGGCAGTGCTTTTACAGGACAACAAGGATATGAAAATTCAGGACCAGGGTTCTGGACAGGCTTGGGAACTGGTGGAATACT
AGGATATTTGTTTGGCAGCAATAGAGCGGCAACACCCTTCTCAGACTCGTGGTACTACCCGTCCTATCCTCCCTCCTACCCTGGCACGTG
GAATAGGGCTTACTCACCCCTTCATGGAGGCTCGGGCAGCTATTCGGTATGTTCAAACTCAGACACGAAAACCAGAACTGCATCAGGATA
TGGTGGTACCAGGAGACGATAAAGTAGAAAGTTGGAGTCAAACACTGGATGCAGAAATTTTGGATTTTTCATCACTTTCTCTTTAGAAAA
AAAGTACTACCTGTTAACAATTGGGAAAAGGGGATATTCAAAAGTTCTGTGGTGTTATGTCCAGTGTAGCTTTTTGTATTCTATTATTTG
AGGCTAAAAGTTGATGTGTGACAAAATACTTATGTGTTGTATGTCAGTGTAACATGCAGATGTATATTGCAGTTTTTGAAAGTGATCATT
ACTGTGGAATGCTAAAAATACATTAATTTCTAAAACCTGTGATGCCCTAAGAAGCATTAAGAATGAAGGTGTTGTACTAATAGAAACTAA
GTACAGAAAATTTCAGTTTTAGGTGGTTGTAGCTGATGAGTTATTACCTCATAGAGACTATAATATTCTATTTGGTATTATATTATTTGA
TGTTTGCTGTTCTTCAAACATTTAAATCAAGCTTTGGACTAATTATGCTAATTTGTGAGTTCTGATCACTTTTGAGCTCTGAAGCTTTGA
ATCATTCAGTGGTGGAGATGGCCTTCTGGTAACTGAATATTACCTTCTGTAGGAAAAGGTAGAAAATAAGCATCTAGAAGGTTGTTGTGA
ATGACTCTGTGCTGGCAAAAATGCTTGAAACCTCTATATTTCTTTCGTTCATAAGAGGTAAAGGTCAAATTTTTCAACAAAAGTCTTTTA
ATAACAAAAGCATGCAGTTCTCTGTGAAATCTCAAATATTGTTGTAATAGTCTGTTTCAATCTTAAAAAGAATCAATAAAAACAAACAAG

>78595_78595_2_RTN4-TMEM66_RTN4_chr2_55209650_ENST00000337526_TMEM66_chr8_29927575_ENST00000256255_length(amino acids)=1374AA_BP=1129
MQHHLHPPAMEDLDQSPLVSSSDSPPRPQPAFKYQFVREPEDEEEEEEEEEEDEDEDLEELEVLERKPAAGLSAAPVPTAPAAGAPLMDF
GNDFVPPAPRGPLPAAPPVAPERQPSWDPSPVSSTVPAPSPLSAAAVSPSKLPEDDEPPARPPPPPPASVSPQAEPVWTPPAPAPAAPPS
TPAAPKRRGSSGSVDETLFALPAASEPVIRSSAENMDLKEQPGNTISAGQEDFPSVLLETAASLPSLSPLSAASFKEHEYLGNLSTVLPT
EGTLQENVSEASKEVSEKAKTLLIDRDLTEFSELEYSEMGSSFSVSPKAESAVIVANPREEIIVKNKDEEEKLVSNNILHNQQELPTALT
KLVKEDEVVSSEKAKDSFNEKRVAVEAPMREEYADFKPFERVWEVKDSKEDSDMLAAGGKIESNLESKVDKKCFADSLEQTNHEKDSESS
NDDTSFPSTPEGIKDRSGAYITCAPFNPAATESIATNIFPLLGDPTSENKTDEKKIEEKKAQIVTEKNTSTKTSNPFLVAAQDSETDYVT
TDNLTKVTEEVVANMPEGLTPDLVQEACESELNEVTGTKIAYETKMDLVQTSEVMQESLYPAAQLCPSFEESEATPSPVLPDIVMEAPLN
SAVPSAGASVIQPSSSPLEASSVNYESIKHEPENPPPYEEAMSVSLKKVSGIKEEIKEPENINAALQETEAPYISIACDLIKETKLSAEP
APDFSDYSEMAKVEQPVPDHSELVEDSSPDSEPVDLFSDDSIPDVPQKQDETVMLVKESLTETSFESMIEYENKEKLSALPPEGGKPYLE
SFKLSLDNTKDTLLPDEVSTLSKKEKIPLQMEELSTAVYSNDDLFISKEAQIRETETFSDSSPIEIIDEFPTLISSKTDSFSKLAREYTD
LEVSHKSEIANAPDGAGSLPCTELPHDLSLKNIQPKVEEKISFSDDFSKNGSATSKVLLLPPDVSALATQAEIESIVKPKVLVKEAEKKL
PSDTEKEDRSPSAIFSAELSKTSVVDLLYWRDIKKTGVVFGASLFLLLSLTVFSIVSVTAYIALALLSVTISFRIYKGVIQAIQKSDEGH
PFRAYLESEVAISEELVQKYSNSALGHVNCTIKELRRLFLVDDLVDSLKWECKTDLDIAYKFGKTVVSCEGYESSEDQYVLRGSCGLEYN
LDYTELGLQKLKESGKQHGFASFSDYYYKWSSADSCNMSGLITIVVLLGIAFVVYKLFLSDGQYSPPPYSEYPPFSHRYQRFTNSAGPPP
PGFKSEFTGPQNTGHGATSGFGSAFTGQQGYENSGPGFWTGLGTGGILGYLFGSNRAATPFSDSWYYPSYPPSYPGTWNRAYSPLHGGSG

--------------------------------------------------------------
>78595_78595_3_RTN4-TMEM66_RTN4_chr2_55209650_ENST00000354474_TMEM66_chr8_29927575_ENST00000256255_length(transcript)=4278nt_BP=2664nt
ATGGAAGACCTGGACCAGTCTCCTCTGGTCTCGTCCTCGGACAGCCCACCCCGGCCGCAGCCCGCGTTCAAGTACCAGTTCGTGAGGGAG
CCCGAGGACGAGGAGGAAGAAGAGGAGGAGGAAGAGGAGGACGAGGACGAAGACCTGGAGGAGCTGGAGGTGCTGGAGAGGAAGCAGTTT
TCAGAATTAGAATACTCAGAAATGGGATCATCGTTCAGTGTCTCTCCAAAAGCAGAATCTGCCGTAATAGTAGCAAATCCTAGGGAAGAA
ATAATCGTGAAAAATAAAGATGAAGAAGAGAAGTTAGTTAGTAATAACATCCTTCATAATCAACAAGAGTTACCTACAGCTCTTACTAAA
TTGGTTAAAGAGGATGAAGTTGTGTCTTCAGAAAAAGCAAAAGACAGTTTTAATGAAAAGAGAGTTGCAGTGGAAGCTCCTATGAGGGAG
GAATATGCAGACTTCAAACCATTTGAGCGAGTATGGGAAGTGAAAGATAGTAAGGAAGATAGTGATATGTTGGCTGCTGGAGGTAAAATC
GAGAGCAACTTGGAAAGTAAAGTGGATAAAAAATGTTTTGCAGATAGCCTTGAGCAAACTAATCACGAAAAAGATAGTGAGAGTAGTAAT
GATGATACTTCTTTCCCCAGTACGCCAGAAGGTATAAAGGATCGTTCAGGAGCATATATCACATGTGCTCCCTTTAACCCAGCAGCAACT
GAGAGCATTGCAACAAACATTTTTCCTTTGTTAGGAGATCCTACTTCAGAAAATAAGACCGATGAAAAAAAAATAGAAGAAAAGAAGGCC
CAAATAGTAACAGAGAAGAATACTAGCACCAAAACATCAAACCCTTTTCTTGTAGCAGCACAGGATTCTGAGACAGATTATGTCACAACA
GATAATTTAACAAAGGTGACTGAGGAAGTCGTGGCAAACATGCCTGAAGGCCTGACTCCAGATTTAGTACAGGAAGCATGTGAAAGTGAA
TTGAATGAAGTTACTGGTACAAAGATTGCTTATGAAACAAAAATGGACTTGGTTCAAACATCAGAAGTTATGCAAGAGTCACTCTATCCT
GCAGCACAGCTTTGCCCATCATTTGAAGAGTCAGAAGCTACTCCTTCACCAGTTTTGCCTGACATTGTTATGGAAGCACCATTGAATTCT
GCAGTTCCTAGTGCTGGTGCTTCCGTGATACAGCCCAGCTCATCACCATTAGAAGCTTCTTCAGTTAATTATGAAAGCATAAAACATGAG
CCTGAAAACCCCCCACCATATGAAGAGGCCATGAGTGTATCACTAAAAAAAGTATCAGGAATAAAGGAAGAAATTAAAGAGCCTGAAAAT
ATTAATGCAGCTCTTCAAGAAACAGAAGCTCCTTATATATCTATTGCATGTGATTTAATTAAAGAAACAAAGCTTTCTGCTGAACCAGCT
CCGGATTTCTCTGATTATTCAGAAATGGCAAAAGTTGAACAGCCAGTGCCTGATCATTCTGAGCTAGTTGAAGATTCCTCACCTGATTCT
GAACCAGTTGACTTATTTAGTGATGATTCAATACCTGACGTTCCACAAAAACAAGATGAAACTGTGATGCTTGTGAAAGAAAGTCTCACT
GAGACTTCATTTGAGTCAATGATAGAATATGAAAATAAGGAAAAACTCAGTGCTTTGCCACCTGAGGGAGGAAAGCCATATTTGGAATCT
TTTAAGCTCAGTTTAGATAACACAAAAGATACCCTGTTACCTGATGAAGTTTCAACATTGAGCAAAAAGGAGAAAATTCCTTTGCAGATG
GAGGAGCTCAGTACTGCAGTTTATTCAAATGATGACTTATTTATTTCTAAGGAAGCACAGATAAGAGAAACTGAAACGTTTTCAGATTCA
TCTCCAATTGAAATTATAGATGAGTTCCCTACATTGATCAGTTCTAAAACTGATTCATTTTCTAAATTAGCCAGGGAATATACTGACCTA
GAAGTATCCCACAAAAGTGAAATTGCTAATGCCCCGGATGGAGCTGGGTCATTGCCTTGCACAGAATTGCCCCATGACCTTTCTTTGAAG
AACATACAACCCAAAGTTGAAGAGAAAATCAGTTTCTCAGATGACTTTTCTAAAAATGGGTCTGCTACATCAAAGGTGCTCTTATTGCCT
CCAGATGTTTCTGCTTTGGCCACTCAAGCAGAGATAGAGAGCATAGTTAAACCCAAAGTTCTTGTGAAAGAAGCTGAGAAAAAACTTCCT
TCCGATACAGAAAAAGAGGACAGATCACCATCTGCTATATTTTCAGCAGAGCTGAGTAAAACTTCAGTTGTTGACCTCCTGTACTGGAGA
GACATTAAGAAGACTGGAGTGGTGTTTGGTGCCAGCCTATTCCTGCTGCTTTCATTGACAGTATTCAGCATTGTGAGCGTAACAGCCTAC
ATTGCCTTGGCCCTGCTCTCTGTGACCATCAGCTTTAGGATATACAAGGGTGTGATCCAAGCTATCCAGAAATCAGATGAAGGCCACCCA
TTCAGGGCATATCTGGAATCTGAAGTTGCTATATCTGAGGAGTTGGTTCAGAAGTACAGTAATTCTGCTCTTGGTCATGTGAACTGCACG
ATAAAGGAACTCAGGCGCCTCTTCTTAGTTGATGATTTAGTTGATTCTCTGAAGTGGGAATGTAAGACGGACTTAGATATTGCATACAAA
TTTGGAAAAACTGTGGTGAGCTGTGAAGGCTATGAGTCCTCTGAAGACCAGTATGTACTAAGAGGTTCTTGTGGCTTGGAGTATAATTTA
GATTATACAGAACTTGGCCTGCAGAAACTGAAGGAGTCTGGAAAGCAGCACGGCTTTGCCTCTTTCTCTGATTATTATTATAAGTGGTCC
TCGGCGGATTCCTGTAACATGAGTGGATTGATTACCATTGTGGTACTCCTTGGGATCGCGTTTGTAGTCTATAAGCTGTTCCTGAGTGAC
GGGCAGTATTCTCCTCCACCGTACTCTGAGTATCCTCCATTTTCCCACCGTTACCAGAGATTCACCAACTCAGCAGGACCTCCTCCCCCA
GGCTTTAAGTCTGAGTTCACAGGACCACAGAATACTGGCCATGGTGCAACTTCTGGTTTTGGCAGTGCTTTTACAGGACAACAAGGATAT
GAAAATTCAGGACCAGGGTTCTGGACAGGCTTGGGAACTGGTGGAATACTAGGATATTTGTTTGGCAGCAATAGAGCGGCAACACCCTTC
TCAGACTCGTGGTACTACCCGTCCTATCCTCCCTCCTACCCTGGCACGTGGAATAGGGCTTACTCACCCCTTCATGGAGGCTCGGGCAGC
TATTCGGTATGTTCAAACTCAGACACGAAAACCAGAACTGCATCAGGATATGGTGGTACCAGGAGACGATAAAGTAGAAAGTTGGAGTCA
AACACTGGATGCAGAAATTTTGGATTTTTCATCACTTTCTCTTTAGAAAAAAAGTACTACCTGTTAACAATTGGGAAAAGGGGATATTCA
AAAGTTCTGTGGTGTTATGTCCAGTGTAGCTTTTTGTATTCTATTATTTGAGGCTAAAAGTTGATGTGTGACAAAATACTTATGTGTTGT
ATGTCAGTGTAACATGCAGATGTATATTGCAGTTTTTGAAAGTGATCATTACTGTGGAATGCTAAAAATACATTAATTTCTAAAACCTGT
GATGCCCTAAGAAGCATTAAGAATGAAGGTGTTGTACTAATAGAAACTAAGTACAGAAAATTTCAGTTTTAGGTGGTTGTAGCTGATGAG
TTATTACCTCATAGAGACTATAATATTCTATTTGGTATTATATTATTTGATGTTTGCTGTTCTTCAAACATTTAAATCAAGCTTTGGACT
AATTATGCTAATTTGTGAGTTCTGATCACTTTTGAGCTCTGAAGCTTTGAATCATTCAGTGGTGGAGATGGCCTTCTGGTAACTGAATAT
TACCTTCTGTAGGAAAAGGTAGAAAATAAGCATCTAGAAGGTTGTTGTGAATGACTCTGTGCTGGCAAAAATGCTTGAAACCTCTATATT
TCTTTCGTTCATAAGAGGTAAAGGTCAAATTTTTCAACAAAAGTCTTTTAATAACAAAAGCATGCAGTTCTCTGTGAAATCTCAAATATT
GTTGTAATAGTCTGTTTCAATCTTAAAAAGAATCAATAAAAACAAACAAGGGGTTTAGTCTCATTCTTTCTATTAGCCTAGGCGCAAATA

>78595_78595_3_RTN4-TMEM66_RTN4_chr2_55209650_ENST00000354474_TMEM66_chr8_29927575_ENST00000256255_length(amino acids)=1133AA_BP=888
MEDLDQSPLVSSSDSPPRPQPAFKYQFVREPEDEEEEEEEEEEDEDEDLEELEVLERKQFSELEYSEMGSSFSVSPKAESAVIVANPREE
IIVKNKDEEEKLVSNNILHNQQELPTALTKLVKEDEVVSSEKAKDSFNEKRVAVEAPMREEYADFKPFERVWEVKDSKEDSDMLAAGGKI
ESNLESKVDKKCFADSLEQTNHEKDSESSNDDTSFPSTPEGIKDRSGAYITCAPFNPAATESIATNIFPLLGDPTSENKTDEKKIEEKKA
QIVTEKNTSTKTSNPFLVAAQDSETDYVTTDNLTKVTEEVVANMPEGLTPDLVQEACESELNEVTGTKIAYETKMDLVQTSEVMQESLYP
AAQLCPSFEESEATPSPVLPDIVMEAPLNSAVPSAGASVIQPSSSPLEASSVNYESIKHEPENPPPYEEAMSVSLKKVSGIKEEIKEPEN
INAALQETEAPYISIACDLIKETKLSAEPAPDFSDYSEMAKVEQPVPDHSELVEDSSPDSEPVDLFSDDSIPDVPQKQDETVMLVKESLT
ETSFESMIEYENKEKLSALPPEGGKPYLESFKLSLDNTKDTLLPDEVSTLSKKEKIPLQMEELSTAVYSNDDLFISKEAQIRETETFSDS
SPIEIIDEFPTLISSKTDSFSKLAREYTDLEVSHKSEIANAPDGAGSLPCTELPHDLSLKNIQPKVEEKISFSDDFSKNGSATSKVLLLP
PDVSALATQAEIESIVKPKVLVKEAEKKLPSDTEKEDRSPSAIFSAELSKTSVVDLLYWRDIKKTGVVFGASLFLLLSLTVFSIVSVTAY
IALALLSVTISFRIYKGVIQAIQKSDEGHPFRAYLESEVAISEELVQKYSNSALGHVNCTIKELRRLFLVDDLVDSLKWECKTDLDIAYK
FGKTVVSCEGYESSEDQYVLRGSCGLEYNLDYTELGLQKLKESGKQHGFASFSDYYYKWSSADSCNMSGLITIVVLLGIAFVVYKLFLSD
GQYSPPPYSEYPPFSHRYQRFTNSAGPPPPGFKSEFTGPQNTGHGATSGFGSAFTGQQGYENSGPGFWTGLGTGGILGYLFGSNRAATPF

--------------------------------------------------------------
>78595_78595_4_RTN4-TMEM66_RTN4_chr2_55209650_ENST00000357732_TMEM66_chr8_29927575_ENST00000256255_length(transcript)=2818nt_BP=1204nt
GCTGGCCTCACTCCTAGCTCATCTGGGCGGCGGCGGCAAGTGGGGACAGGGCGGGTGGCGCATCACCGGCGCGGAGGCAGGAGGAGCAGT
CTCATTGTTCCGGGAGCCGTCACCACAGTAGGTCCCTCGGCTCAGTCGGCCCAGCCCCTCTCAGTCCTCCCCAACCCCCACAACCGCCCG
CGGCTCTGAGACGCGGCCCCGGCGGCGGCGGCAGCAGCTGCAGCATCATCTCCACCCTCCAGCCATGGAAGACCTGGACCAGTCTCCTCT
GGTCTCGTCCTCGGACAGCCCACCCCGGCCGCAGCCCGCGTTCAAGTACCAGTTCGTGAGGGAGCCCGAGGACGAGGAGGAAGAAGAGGA
GGAGGAAGAGGAGGACGAGGACGAAGACCTGGAGGAGCTGGAGGTGCTGGAGAGGAAGCCCGCCGCCGGGCTGTCCGCGGCCCCAGTGCC
CACCGCCCCTGCCGCCGGCGCGCCCCTGATGGACTTCGGAAATGACTTCGTGCCGCCGGCGCCCCGGGGACCCCTGCCGGCCGCTCCCCC
CGTCGCCCCGGAGCGGCAGCCGTCTTGGGACCCGAGCCCGGTGTCGTCGACCGTGCCCGCGCCATCCCCGCTGTCTGCTGCCGCAGTCTC
GCCCTCCAAGCTCCCTGAGGACGACGAGCCTCCGGCCCGGCCTCCCCCTCCTCCCCCGGCCAGCGTGAGCCCCCAGGCAGAGCCCGTGTG
GACCCCGCCAGCCCCGGCTCCCGCCGCGCCCCCCTCCACCCCGGCCGCGCCCAAGCGCAGGGGCTCCTCGGGCTCAGTGGATGAGACCCT
TTTTGCTCTTCCTGCTGCATCTGAGCCTGTGATACGCTCCTCTGCAGTTGTTGACCTCCTGTACTGGAGAGACATTAAGAAGACTGGAGT
GGTGTTTGGTGCCAGCCTATTCCTGCTGCTTTCATTGACAGTATTCAGCATTGTGAGCGTAACAGCCTACATTGCCTTGGCCCTGCTCTC
TGTGACCATCAGCTTTAGGATATACAAGGGTGTGATCCAAGCTATCCAGAAATCAGATGAAGGCCACCCATTCAGGGCATATCTGGAATC
TGAAGTTGCTATATCTGAGGAGTTGGTTCAGAAGTACAGTAATTCTGCTCTTGGTCATGTGAACTGCACGATAAAGGAACTCAGGCGCCT
CTTCTTAGTTGATGATTTAGTTGATTCTCTGAAGTGGGAATGTAAGACGGACTTAGATATTGCATACAAATTTGGAAAAACTGTGGTGAG
CTGTGAAGGCTATGAGTCCTCTGAAGACCAGTATGTACTAAGAGGTTCTTGTGGCTTGGAGTATAATTTAGATTATACAGAACTTGGCCT
GCAGAAACTGAAGGAGTCTGGAAAGCAGCACGGCTTTGCCTCTTTCTCTGATTATTATTATAAGTGGTCCTCGGCGGATTCCTGTAACAT
GAGTGGATTGATTACCATTGTGGTACTCCTTGGGATCGCGTTTGTAGTCTATAAGCTGTTCCTGAGTGACGGGCAGTATTCTCCTCCACC
GTACTCTGAGTATCCTCCATTTTCCCACCGTTACCAGAGATTCACCAACTCAGCAGGACCTCCTCCCCCAGGCTTTAAGTCTGAGTTCAC
AGGACCACAGAATACTGGCCATGGTGCAACTTCTGGTTTTGGCAGTGCTTTTACAGGACAACAAGGATATGAAAATTCAGGACCAGGGTT
CTGGACAGGCTTGGGAACTGGTGGAATACTAGGATATTTGTTTGGCAGCAATAGAGCGGCAACACCCTTCTCAGACTCGTGGTACTACCC
GTCCTATCCTCCCTCCTACCCTGGCACGTGGAATAGGGCTTACTCACCCCTTCATGGAGGCTCGGGCAGCTATTCGGTATGTTCAAACTC
AGACACGAAAACCAGAACTGCATCAGGATATGGTGGTACCAGGAGACGATAAAGTAGAAAGTTGGAGTCAAACACTGGATGCAGAAATTT
TGGATTTTTCATCACTTTCTCTTTAGAAAAAAAGTACTACCTGTTAACAATTGGGAAAAGGGGATATTCAAAAGTTCTGTGGTGTTATGT
CCAGTGTAGCTTTTTGTATTCTATTATTTGAGGCTAAAAGTTGATGTGTGACAAAATACTTATGTGTTGTATGTCAGTGTAACATGCAGA
TGTATATTGCAGTTTTTGAAAGTGATCATTACTGTGGAATGCTAAAAATACATTAATTTCTAAAACCTGTGATGCCCTAAGAAGCATTAA
GAATGAAGGTGTTGTACTAATAGAAACTAAGTACAGAAAATTTCAGTTTTAGGTGGTTGTAGCTGATGAGTTATTACCTCATAGAGACTA
TAATATTCTATTTGGTATTATATTATTTGATGTTTGCTGTTCTTCAAACATTTAAATCAAGCTTTGGACTAATTATGCTAATTTGTGAGT
TCTGATCACTTTTGAGCTCTGAAGCTTTGAATCATTCAGTGGTGGAGATGGCCTTCTGGTAACTGAATATTACCTTCTGTAGGAAAAGGT
AGAAAATAAGCATCTAGAAGGTTGTTGTGAATGACTCTGTGCTGGCAAAAATGCTTGAAACCTCTATATTTCTTTCGTTCATAAGAGGTA
AAGGTCAAATTTTTCAACAAAAGTCTTTTAATAACAAAAGCATGCAGTTCTCTGTGAAATCTCAAATATTGTTGTAATAGTCTGTTTCAA
TCTTAAAAAGAATCAATAAAAACAAACAAGGGGTTTAGTCTCATTCTTTCTATTAGCCTAGGCGCAAATAAATGTTACTTTTTGTTTTTT

>78595_78595_4_RTN4-TMEM66_RTN4_chr2_55209650_ENST00000357732_TMEM66_chr8_29927575_ENST00000256255_length(amino acids)=574AA_BP=329
MQHHLHPPAMEDLDQSPLVSSSDSPPRPQPAFKYQFVREPEDEEEEEEEEEEDEDEDLEELEVLERKPAAGLSAAPVPTAPAAGAPLMDF
GNDFVPPAPRGPLPAAPPVAPERQPSWDPSPVSSTVPAPSPLSAAAVSPSKLPEDDEPPARPPPPPPASVSPQAEPVWTPPAPAPAAPPS
TPAAPKRRGSSGSVDETLFALPAASEPVIRSSAVVDLLYWRDIKKTGVVFGASLFLLLSLTVFSIVSVTAYIALALLSVTISFRIYKGVI
QAIQKSDEGHPFRAYLESEVAISEELVQKYSNSALGHVNCTIKELRRLFLVDDLVDSLKWECKTDLDIAYKFGKTVVSCEGYESSEDQYV
LRGSCGLEYNLDYTELGLQKLKESGKQHGFASFSDYYYKWSSADSCNMSGLITIVVLLGIAFVVYKLFLSDGQYSPPPYSEYPPFSHRYQ
RFTNSAGPPPPGFKSEFTGPQNTGHGATSGFGSAFTGQQGYENSGPGFWTGLGTGGILGYLFGSNRAATPFSDSWYYPSYPPSYPGTWNR

--------------------------------------------------------------
>78595_78595_5_RTN4-TMEM66_RTN4_chr2_55209650_ENST00000394609_TMEM66_chr8_29927575_ENST00000256255_length(transcript)=2324nt_BP=710nt
TCTTTTGGTAGCCTGCCCTCTCCCTGCAAATGCAGCTCCATTTGGTATGAGCAACAAGGCAAATGCCTAAAACAATCAACAGATAGAAGG
AAAGCATTAATGCTGGAGTATTAGTAGCCTAGTTACAGATTGCACTGCGTCAGACTGTTCCACACCCAGAAGACGTCAGGTGACTTCAGT
CCTGCTGCAGTTGTGCAGCAGAGGAGACTGCAGACTTCGGTTGAGGAAACGGGTATTTCATGTCTCAGGGAGTAGGTTTGTGCAGTTACA
GCTTTTCTGTTGGTATGCATAATTAATAATTGGAGCTGCAAAGCAGATCGTGACAAGAGATGGACGGTCAGAAGAAAAATTGGAAGGACA
AGGTTGTTGACCTCCTGTACTGGAGAGACATTAAGAAGACTGGAGTGGTGTTTGGTGCCAGCCTATTCCTGCTGCTTTCATTGACAGTAT
TCAGCATTGTGAGCGTAACAGCCTACATTGCCTTGGCCCTGCTCTCTGTGACCATCAGCTTTAGGATATACAAGGGTGTGATCCAAGCTA
TCCAGAAATCAGATGAAGGCCACCCATTCAGGGCATATCTGGAATCTGAAGTTGCTATATCTGAGGAGTTGGTTCAGAAGTACAGTAATT
CTGCTCTTGGTCATGTGAACTGCACGATAAAGGAACTCAGGCGCCTCTTCTTAGTTGATGATTTAGTTGATTCTCTGAAGTGGGAATGTA
AGACGGACTTAGATATTGCATACAAATTTGGAAAAACTGTGGTGAGCTGTGAAGGCTATGAGTCCTCTGAAGACCAGTATGTACTAAGAG
GTTCTTGTGGCTTGGAGTATAATTTAGATTATACAGAACTTGGCCTGCAGAAACTGAAGGAGTCTGGAAAGCAGCACGGCTTTGCCTCTT
TCTCTGATTATTATTATAAGTGGTCCTCGGCGGATTCCTGTAACATGAGTGGATTGATTACCATTGTGGTACTCCTTGGGATCGCGTTTG
TAGTCTATAAGCTGTTCCTGAGTGACGGGCAGTATTCTCCTCCACCGTACTCTGAGTATCCTCCATTTTCCCACCGTTACCAGAGATTCA
CCAACTCAGCAGGACCTCCTCCCCCAGGCTTTAAGTCTGAGTTCACAGGACCACAGAATACTGGCCATGGTGCAACTTCTGGTTTTGGCA
GTGCTTTTACAGGACAACAAGGATATGAAAATTCAGGACCAGGGTTCTGGACAGGCTTGGGAACTGGTGGAATACTAGGATATTTGTTTG
GCAGCAATAGAGCGGCAACACCCTTCTCAGACTCGTGGTACTACCCGTCCTATCCTCCCTCCTACCCTGGCACGTGGAATAGGGCTTACT
CACCCCTTCATGGAGGCTCGGGCAGCTATTCGGTATGTTCAAACTCAGACACGAAAACCAGAACTGCATCAGGATATGGTGGTACCAGGA
GACGATAAAGTAGAAAGTTGGAGTCAAACACTGGATGCAGAAATTTTGGATTTTTCATCACTTTCTCTTTAGAAAAAAAGTACTACCTGT
TAACAATTGGGAAAAGGGGATATTCAAAAGTTCTGTGGTGTTATGTCCAGTGTAGCTTTTTGTATTCTATTATTTGAGGCTAAAAGTTGA
TGTGTGACAAAATACTTATGTGTTGTATGTCAGTGTAACATGCAGATGTATATTGCAGTTTTTGAAAGTGATCATTACTGTGGAATGCTA
AAAATACATTAATTTCTAAAACCTGTGATGCCCTAAGAAGCATTAAGAATGAAGGTGTTGTACTAATAGAAACTAAGTACAGAAAATTTC
AGTTTTAGGTGGTTGTAGCTGATGAGTTATTACCTCATAGAGACTATAATATTCTATTTGGTATTATATTATTTGATGTTTGCTGTTCTT
CAAACATTTAAATCAAGCTTTGGACTAATTATGCTAATTTGTGAGTTCTGATCACTTTTGAGCTCTGAAGCTTTGAATCATTCAGTGGTG
GAGATGGCCTTCTGGTAACTGAATATTACCTTCTGTAGGAAAAGGTAGAAAATAAGCATCTAGAAGGTTGTTGTGAATGACTCTGTGCTG
GCAAAAATGCTTGAAACCTCTATATTTCTTTCGTTCATAAGAGGTAAAGGTCAAATTTTTCAACAAAAGTCTTTTAATAACAAAAGCATG
CAGTTCTCTGTGAAATCTCAAATATTGTTGTAATAGTCTGTTTCAATCTTAAAAAGAATCAATAAAAACAAACAAGGGGTTTAGTCTCAT

>78595_78595_5_RTN4-TMEM66_RTN4_chr2_55209650_ENST00000394609_TMEM66_chr8_29927575_ENST00000256255_length(amino acids)=372AA_BP=127
MDGQKKNWKDKVVDLLYWRDIKKTGVVFGASLFLLLSLTVFSIVSVTAYIALALLSVTISFRIYKGVIQAIQKSDEGHPFRAYLESEVAI
SEELVQKYSNSALGHVNCTIKELRRLFLVDDLVDSLKWECKTDLDIAYKFGKTVVSCEGYESSEDQYVLRGSCGLEYNLDYTELGLQKLK
ESGKQHGFASFSDYYYKWSSADSCNMSGLITIVVLLGIAFVVYKLFLSDGQYSPPPYSEYPPFSHRYQRFTNSAGPPPPGFKSEFTGPQN
TGHGATSGFGSAFTGQQGYENSGPGFWTGLGTGGILGYLFGSNRAATPFSDSWYYPSYPPSYPGTWNRAYSPLHGGSGSYSVCSNSDTKT

--------------------------------------------------------------
>78595_78595_6_RTN4-TMEM66_RTN4_chr2_55209650_ENST00000402434_TMEM66_chr8_29927575_ENST00000256255_length(transcript)=2509nt_BP=895nt
CACAACCGCCCGCGGCTCTGAGACGCGGCCCCGGCGGCGGCGGCAGCAGCTGCAGCATCATCTCCACCCTCCAGCCATGGAGCCCGAGGA
CGAGGAGGAAGAAGAGGAGGAGGAAGAGGAGGACGAGGACGAAGACCTGGAGGAGCTGGAGGTGCTGGAGAGGAAGCCCGCCGCCGGGCT
GTCCGCGGCCCCAGTGCCCACCGCCCCTGCCGCCGGCGCGCCCCTGATGGACTTCGGAAATGACTTCGTGCCGCCGGCGCCCCGGGGACC
CCTGCCGGCCGCTCCCCCCGTCGCCCCGGAGCGGCAGCCGTCTTGGGACCCGAGCCCGGTGTCGTCGACCGTGCCCGCGCCATCCCCGCT
GTCTGCTGCCGCAGTCTCGCCCTCCAAGCTCCCTGAGGACGACGAGCCTCCGGCCCGGCCTCCCCCTCCTCCCCCGGCCAGCGTGAGCCC
CCAGGCAGAGCCCGTGTGGACCCCGCCAGCCCCGGCTCCCGCCGCGCCCCCCTCCACCCCGGCCGCGCCCAAGCGCAGGGGCTCCTCGGG
CTCAGTGGTTGTTGACCTCCTGTACTGGAGAGACATTAAGAAGACTGGAGTGGTGTTTGGTGCCAGCCTATTCCTGCTGCTTTCATTGAC
AGTATTCAGCATTGTGAGCGTAACAGCCTACATTGCCTTGGCCCTGCTCTCTGTGACCATCAGCTTTAGGATATACAAGGGTGTGATCCA
AGCTATCCAGAAATCAGATGAAGGCCACCCATTCAGGGCATATCTGGAATCTGAAGTTGCTATATCTGAGGAGTTGGTTCAGAAGTACAG
TAATTCTGCTCTTGGTCATGTGAACTGCACGATAAAGGAACTCAGGCGCCTCTTCTTAGTTGATGATTTAGTTGATTCTCTGAAGTGGGA
ATGTAAGACGGACTTAGATATTGCATACAAATTTGGAAAAACTGTGGTGAGCTGTGAAGGCTATGAGTCCTCTGAAGACCAGTATGTACT
AAGAGGTTCTTGTGGCTTGGAGTATAATTTAGATTATACAGAACTTGGCCTGCAGAAACTGAAGGAGTCTGGAAAGCAGCACGGCTTTGC
CTCTTTCTCTGATTATTATTATAAGTGGTCCTCGGCGGATTCCTGTAACATGAGTGGATTGATTACCATTGTGGTACTCCTTGGGATCGC
GTTTGTAGTCTATAAGCTGTTCCTGAGTGACGGGCAGTATTCTCCTCCACCGTACTCTGAGTATCCTCCATTTTCCCACCGTTACCAGAG
ATTCACCAACTCAGCAGGACCTCCTCCCCCAGGCTTTAAGTCTGAGTTCACAGGACCACAGAATACTGGCCATGGTGCAACTTCTGGTTT
TGGCAGTGCTTTTACAGGACAACAAGGATATGAAAATTCAGGACCAGGGTTCTGGACAGGCTTGGGAACTGGTGGAATACTAGGATATTT
GTTTGGCAGCAATAGAGCGGCAACACCCTTCTCAGACTCGTGGTACTACCCGTCCTATCCTCCCTCCTACCCTGGCACGTGGAATAGGGC
TTACTCACCCCTTCATGGAGGCTCGGGCAGCTATTCGGTATGTTCAAACTCAGACACGAAAACCAGAACTGCATCAGGATATGGTGGTAC
CAGGAGACGATAAAGTAGAAAGTTGGAGTCAAACACTGGATGCAGAAATTTTGGATTTTTCATCACTTTCTCTTTAGAAAAAAAGTACTA
CCTGTTAACAATTGGGAAAAGGGGATATTCAAAAGTTCTGTGGTGTTATGTCCAGTGTAGCTTTTTGTATTCTATTATTTGAGGCTAAAA
GTTGATGTGTGACAAAATACTTATGTGTTGTATGTCAGTGTAACATGCAGATGTATATTGCAGTTTTTGAAAGTGATCATTACTGTGGAA
TGCTAAAAATACATTAATTTCTAAAACCTGTGATGCCCTAAGAAGCATTAAGAATGAAGGTGTTGTACTAATAGAAACTAAGTACAGAAA
ATTTCAGTTTTAGGTGGTTGTAGCTGATGAGTTATTACCTCATAGAGACTATAATATTCTATTTGGTATTATATTATTTGATGTTTGCTG
TTCTTCAAACATTTAAATCAAGCTTTGGACTAATTATGCTAATTTGTGAGTTCTGATCACTTTTGAGCTCTGAAGCTTTGAATCATTCAG
TGGTGGAGATGGCCTTCTGGTAACTGAATATTACCTTCTGTAGGAAAAGGTAGAAAATAAGCATCTAGAAGGTTGTTGTGAATGACTCTG
TGCTGGCAAAAATGCTTGAAACCTCTATATTTCTTTCGTTCATAAGAGGTAAAGGTCAAATTTTTCAACAAAAGTCTTTTAATAACAAAA
GCATGCAGTTCTCTGTGAAATCTCAAATATTGTTGTAATAGTCTGTTTCAATCTTAAAAAGAATCAATAAAAACAAACAAGGGGTTTAGT

>78595_78595_6_RTN4-TMEM66_RTN4_chr2_55209650_ENST00000402434_TMEM66_chr8_29927575_ENST00000256255_length(amino acids)=527AA_BP=282
MQHHLHPPAMEPEDEEEEEEEEEEDEDEDLEELEVLERKPAAGLSAAPVPTAPAAGAPLMDFGNDFVPPAPRGPLPAAPPVAPERQPSWD
PSPVSSTVPAPSPLSAAAVSPSKLPEDDEPPARPPPPPPASVSPQAEPVWTPPAPAPAAPPSTPAAPKRRGSSGSVVVDLLYWRDIKKTG
VVFGASLFLLLSLTVFSIVSVTAYIALALLSVTISFRIYKGVIQAIQKSDEGHPFRAYLESEVAISEELVQKYSNSALGHVNCTIKELRR
LFLVDDLVDSLKWECKTDLDIAYKFGKTVVSCEGYESSEDQYVLRGSCGLEYNLDYTELGLQKLKESGKQHGFASFSDYYYKWSSADSCN
MSGLITIVVLLGIAFVVYKLFLSDGQYSPPPYSEYPPFSHRYQRFTNSAGPPPPGFKSEFTGPQNTGHGATSGFGSAFTGQQGYENSGPG

--------------------------------------------------------------

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Fusion Gene PPI Analysis for RTN4-TMEM66


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for RTN4-TMEM66


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for RTN4-TMEM66


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource