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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:RUFY3-PTK2 (FusionGDB2 ID:78627)

Fusion Gene Summary for RUFY3-PTK2

check button Fusion gene summary
Fusion gene informationFusion gene name: RUFY3-PTK2
Fusion gene ID: 78627
HgeneTgene
Gene symbol

RUFY3

PTK2

Gene ID

79443

5747

Gene nameFYVE and coiled-coil domain autophagy adaptor 1protein tyrosine kinase 2
SynonymsCATC2|CTRCT18|RUFY3|ZFYVE7FADK|FAK|FAK1|FRNK|PPP1R71|p125FAK|pp125FAK
Cytomap

3p21.31

8q24.3

Type of geneprotein-codingprotein-coding
DescriptionFYVE and coiled-coil domain-containing protein 1FYVE and coiled-coil domain containing 1RUN and FYVE domain containing 3zinc finger FYVE domain-containing protein 7focal adhesion kinase 1FADK 1FAK-related non-kinase polypeptidePTK2 protein tyrosine kinase 2focal adhesion kinase isoform FAK-Del33focal adhesion kinase-related nonkinaseprotein phosphatase 1 regulatory subunit 71
Modification date2020031320200327
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000381006, ENST00000502653, 
ENST00000226328, ENST00000417478, 
ENST00000512331, ENST00000536664, 
ENST00000340930, ENST00000395218, 
ENST00000430260, ENST00000517712, 
ENST00000517887, ENST00000519419, 
ENST00000519465, ENST00000519635, 
ENST00000519881, ENST00000520151, 
ENST00000520892, ENST00000521059, 
ENST00000522950, ENST00000538769, 
ENST00000522684, ENST00000535192, 
Fusion gene scores* DoF score7 X 6 X 4=16819 X 20 X 13=4940
# samples 729
** MAII scorelog2(7/168*10)=-1.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(29/4940*10)=-4.09038623645711
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: RUFY3 [Title/Abstract] AND PTK2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointRUFY3(71660611)-PTK2(141889736), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgenePTK2

GO:0007179

transforming growth factor beta receptor signaling pathway

24036928

TgenePTK2

GO:0007229

integrin-mediated signaling pathway

24036928

TgenePTK2

GO:0010763

positive regulation of fibroblast migration

26763945

TgenePTK2

GO:0018108

peptidyl-tyrosine phosphorylation

10655584|11331870

TgenePTK2

GO:0022408

negative regulation of cell-cell adhesion

21703394

TgenePTK2

GO:0030335

positive regulation of cell migration

11331870|21703394

TgenePTK2

GO:0033628

regulation of cell adhesion mediated by integrin

10655584

TgenePTK2

GO:0046777

protein autophosphorylation

10655584|11331870

TgenePTK2

GO:0048013

ephrin receptor signaling pathway

10655584

TgenePTK2

GO:0060396

growth hormone receptor signaling pathway

10925297

TgenePTK2

GO:0090303

positive regulation of wound healing

26763945


check buttonFusion gene breakpoints across RUFY3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across PTK2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4Non-Cancer135NRUFY3chr4

71660611

+PTK2chr8

141889736

-


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Fusion Gene ORF analysis for RUFY3-PTK2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000381006ENST00000340930RUFY3chr4

71660611

+PTK2chr8

141889736

-
5CDS-intronENST00000381006ENST00000395218RUFY3chr4

71660611

+PTK2chr8

141889736

-
5CDS-intronENST00000381006ENST00000430260RUFY3chr4

71660611

+PTK2chr8

141889736

-
5CDS-intronENST00000381006ENST00000517712RUFY3chr4

71660611

+PTK2chr8

141889736

-
5CDS-intronENST00000381006ENST00000517887RUFY3chr4

71660611

+PTK2chr8

141889736

-
5CDS-intronENST00000381006ENST00000519419RUFY3chr4

71660611

+PTK2chr8

141889736

-
5CDS-intronENST00000381006ENST00000519465RUFY3chr4

71660611

+PTK2chr8

141889736

-
5CDS-intronENST00000381006ENST00000519635RUFY3chr4

71660611

+PTK2chr8

141889736

-
5CDS-intronENST00000381006ENST00000519881RUFY3chr4

71660611

+PTK2chr8

141889736

-
5CDS-intronENST00000381006ENST00000520151RUFY3chr4

71660611

+PTK2chr8

141889736

-
5CDS-intronENST00000381006ENST00000520892RUFY3chr4

71660611

+PTK2chr8

141889736

-
5CDS-intronENST00000381006ENST00000521059RUFY3chr4

71660611

+PTK2chr8

141889736

-
5CDS-intronENST00000381006ENST00000522950RUFY3chr4

71660611

+PTK2chr8

141889736

-
5CDS-intronENST00000381006ENST00000538769RUFY3chr4

71660611

+PTK2chr8

141889736

-
5CDS-intronENST00000502653ENST00000340930RUFY3chr4

71660611

+PTK2chr8

141889736

-
5CDS-intronENST00000502653ENST00000395218RUFY3chr4

71660611

+PTK2chr8

141889736

-
5CDS-intronENST00000502653ENST00000430260RUFY3chr4

71660611

+PTK2chr8

141889736

-
5CDS-intronENST00000502653ENST00000517712RUFY3chr4

71660611

+PTK2chr8

141889736

-
5CDS-intronENST00000502653ENST00000517887RUFY3chr4

71660611

+PTK2chr8

141889736

-
5CDS-intronENST00000502653ENST00000519419RUFY3chr4

71660611

+PTK2chr8

141889736

-
5CDS-intronENST00000502653ENST00000519465RUFY3chr4

71660611

+PTK2chr8

141889736

-
5CDS-intronENST00000502653ENST00000519635RUFY3chr4

71660611

+PTK2chr8

141889736

-
5CDS-intronENST00000502653ENST00000519881RUFY3chr4

71660611

+PTK2chr8

141889736

-
5CDS-intronENST00000502653ENST00000520151RUFY3chr4

71660611

+PTK2chr8

141889736

-
5CDS-intronENST00000502653ENST00000520892RUFY3chr4

71660611

+PTK2chr8

141889736

-
5CDS-intronENST00000502653ENST00000521059RUFY3chr4

71660611

+PTK2chr8

141889736

-
5CDS-intronENST00000502653ENST00000522950RUFY3chr4

71660611

+PTK2chr8

141889736

-
5CDS-intronENST00000502653ENST00000538769RUFY3chr4

71660611

+PTK2chr8

141889736

-
In-frameENST00000381006ENST00000522684RUFY3chr4

71660611

+PTK2chr8

141889736

-
In-frameENST00000381006ENST00000535192RUFY3chr4

71660611

+PTK2chr8

141889736

-
In-frameENST00000502653ENST00000522684RUFY3chr4

71660611

+PTK2chr8

141889736

-
In-frameENST00000502653ENST00000535192RUFY3chr4

71660611

+PTK2chr8

141889736

-
intron-3CDSENST00000226328ENST00000522684RUFY3chr4

71660611

+PTK2chr8

141889736

-
intron-3CDSENST00000226328ENST00000535192RUFY3chr4

71660611

+PTK2chr8

141889736

-
intron-3CDSENST00000417478ENST00000522684RUFY3chr4

71660611

+PTK2chr8

141889736

-
intron-3CDSENST00000417478ENST00000535192RUFY3chr4

71660611

+PTK2chr8

141889736

-
intron-3CDSENST00000512331ENST00000522684RUFY3chr4

71660611

+PTK2chr8

141889736

-
intron-3CDSENST00000512331ENST00000535192RUFY3chr4

71660611

+PTK2chr8

141889736

-
intron-3CDSENST00000536664ENST00000522684RUFY3chr4

71660611

+PTK2chr8

141889736

-
intron-3CDSENST00000536664ENST00000535192RUFY3chr4

71660611

+PTK2chr8

141889736

-
intron-intronENST00000226328ENST00000340930RUFY3chr4

71660611

+PTK2chr8

141889736

-
intron-intronENST00000226328ENST00000395218RUFY3chr4

71660611

+PTK2chr8

141889736

-
intron-intronENST00000226328ENST00000430260RUFY3chr4

71660611

+PTK2chr8

141889736

-
intron-intronENST00000226328ENST00000517712RUFY3chr4

71660611

+PTK2chr8

141889736

-
intron-intronENST00000226328ENST00000517887RUFY3chr4

71660611

+PTK2chr8

141889736

-
intron-intronENST00000226328ENST00000519419RUFY3chr4

71660611

+PTK2chr8

141889736

-
intron-intronENST00000226328ENST00000519465RUFY3chr4

71660611

+PTK2chr8

141889736

-
intron-intronENST00000226328ENST00000519635RUFY3chr4

71660611

+PTK2chr8

141889736

-
intron-intronENST00000226328ENST00000519881RUFY3chr4

71660611

+PTK2chr8

141889736

-
intron-intronENST00000226328ENST00000520151RUFY3chr4

71660611

+PTK2chr8

141889736

-
intron-intronENST00000226328ENST00000520892RUFY3chr4

71660611

+PTK2chr8

141889736

-
intron-intronENST00000226328ENST00000521059RUFY3chr4

71660611

+PTK2chr8

141889736

-
intron-intronENST00000226328ENST00000522950RUFY3chr4

71660611

+PTK2chr8

141889736

-
intron-intronENST00000226328ENST00000538769RUFY3chr4

71660611

+PTK2chr8

141889736

-
intron-intronENST00000417478ENST00000340930RUFY3chr4

71660611

+PTK2chr8

141889736

-
intron-intronENST00000417478ENST00000395218RUFY3chr4

71660611

+PTK2chr8

141889736

-
intron-intronENST00000417478ENST00000430260RUFY3chr4

71660611

+PTK2chr8

141889736

-
intron-intronENST00000417478ENST00000517712RUFY3chr4

71660611

+PTK2chr8

141889736

-
intron-intronENST00000417478ENST00000517887RUFY3chr4

71660611

+PTK2chr8

141889736

-
intron-intronENST00000417478ENST00000519419RUFY3chr4

71660611

+PTK2chr8

141889736

-
intron-intronENST00000417478ENST00000519465RUFY3chr4

71660611

+PTK2chr8

141889736

-
intron-intronENST00000417478ENST00000519635RUFY3chr4

71660611

+PTK2chr8

141889736

-
intron-intronENST00000417478ENST00000519881RUFY3chr4

71660611

+PTK2chr8

141889736

-
intron-intronENST00000417478ENST00000520151RUFY3chr4

71660611

+PTK2chr8

141889736

-
intron-intronENST00000417478ENST00000520892RUFY3chr4

71660611

+PTK2chr8

141889736

-
intron-intronENST00000417478ENST00000521059RUFY3chr4

71660611

+PTK2chr8

141889736

-
intron-intronENST00000417478ENST00000522950RUFY3chr4

71660611

+PTK2chr8

141889736

-
intron-intronENST00000417478ENST00000538769RUFY3chr4

71660611

+PTK2chr8

141889736

-
intron-intronENST00000512331ENST00000340930RUFY3chr4

71660611

+PTK2chr8

141889736

-
intron-intronENST00000512331ENST00000395218RUFY3chr4

71660611

+PTK2chr8

141889736

-
intron-intronENST00000512331ENST00000430260RUFY3chr4

71660611

+PTK2chr8

141889736

-
intron-intronENST00000512331ENST00000517712RUFY3chr4

71660611

+PTK2chr8

141889736

-
intron-intronENST00000512331ENST00000517887RUFY3chr4

71660611

+PTK2chr8

141889736

-
intron-intronENST00000512331ENST00000519419RUFY3chr4

71660611

+PTK2chr8

141889736

-
intron-intronENST00000512331ENST00000519465RUFY3chr4

71660611

+PTK2chr8

141889736

-
intron-intronENST00000512331ENST00000519635RUFY3chr4

71660611

+PTK2chr8

141889736

-
intron-intronENST00000512331ENST00000519881RUFY3chr4

71660611

+PTK2chr8

141889736

-
intron-intronENST00000512331ENST00000520151RUFY3chr4

71660611

+PTK2chr8

141889736

-
intron-intronENST00000512331ENST00000520892RUFY3chr4

71660611

+PTK2chr8

141889736

-
intron-intronENST00000512331ENST00000521059RUFY3chr4

71660611

+PTK2chr8

141889736

-
intron-intronENST00000512331ENST00000522950RUFY3chr4

71660611

+PTK2chr8

141889736

-
intron-intronENST00000512331ENST00000538769RUFY3chr4

71660611

+PTK2chr8

141889736

-
intron-intronENST00000536664ENST00000340930RUFY3chr4

71660611

+PTK2chr8

141889736

-
intron-intronENST00000536664ENST00000395218RUFY3chr4

71660611

+PTK2chr8

141889736

-
intron-intronENST00000536664ENST00000430260RUFY3chr4

71660611

+PTK2chr8

141889736

-
intron-intronENST00000536664ENST00000517712RUFY3chr4

71660611

+PTK2chr8

141889736

-
intron-intronENST00000536664ENST00000517887RUFY3chr4

71660611

+PTK2chr8

141889736

-
intron-intronENST00000536664ENST00000519419RUFY3chr4

71660611

+PTK2chr8

141889736

-
intron-intronENST00000536664ENST00000519465RUFY3chr4

71660611

+PTK2chr8

141889736

-
intron-intronENST00000536664ENST00000519635RUFY3chr4

71660611

+PTK2chr8

141889736

-
intron-intronENST00000536664ENST00000519881RUFY3chr4

71660611

+PTK2chr8

141889736

-
intron-intronENST00000536664ENST00000520151RUFY3chr4

71660611

+PTK2chr8

141889736

-
intron-intronENST00000536664ENST00000520892RUFY3chr4

71660611

+PTK2chr8

141889736

-
intron-intronENST00000536664ENST00000521059RUFY3chr4

71660611

+PTK2chr8

141889736

-
intron-intronENST00000536664ENST00000522950RUFY3chr4

71660611

+PTK2chr8

141889736

-
intron-intronENST00000536664ENST00000538769RUFY3chr4

71660611

+PTK2chr8

141889736

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000381006RUFY3chr471660611+ENST00000522684PTK2chr8141889736-6666213657950991506
ENST00000381006RUFY3chr471660611+ENST00000535192PTK2chr8141889736-6037213657949611460
ENST00000502653RUFY3chr471660611+ENST00000522684PTK2chr8141889736-6123159317445561460
ENST00000502653RUFY3chr471660611+ENST00000535192PTK2chr8141889736-5494159317444181414

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000381006ENST00000522684RUFY3chr471660611+PTK2chr8141889736-0.0014529520.998547
ENST00000381006ENST00000535192RUFY3chr471660611+PTK2chr8141889736-0.0009202890.9990797
ENST00000502653ENST00000522684RUFY3chr471660611+PTK2chr8141889736-0.0011430690.9988569
ENST00000502653ENST00000535192RUFY3chr471660611+PTK2chr8141889736-0.0007593350.99924064

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Fusion Genomic Features for RUFY3-PTK2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for RUFY3-PTK2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr4:71660611/chr8:141889736)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneRUFY3chr4:71660611chr8:141889736ENST00000381006+1418267_464519621.0Coiled coilOntology_term=ECO:0000255
HgeneRUFY3chr4:71660611chr8:141889736ENST00000502653+1519267_464466568.0Coiled coilOntology_term=ECO:0000255
HgeneRUFY3chr4:71660611chr8:141889736ENST00000381006+141895_227519621.0DomainRUN
HgeneRUFY3chr4:71660611chr8:141889736ENST00000502653+151995_227466568.0DomainRUN
TgenePTK2chr4:71660611chr8:141889736ENST00000340930233712_733651066.0Compositional biasNote=Pro-rich
TgenePTK2chr4:71660611chr8:141889736ENST00000340930233863_913651066.0Compositional biasNote=Pro-rich
TgenePTK2chr4:71660611chr8:141889736ENST00000521059232712_733651053.0Compositional biasNote=Pro-rich
TgenePTK2chr4:71660611chr8:141889736ENST00000521059232863_913651053.0Compositional biasNote=Pro-rich
TgenePTK2chr4:71660611chr8:141889736ENST00000522684232712_733651053.0Compositional biasNote=Pro-rich
TgenePTK2chr4:71660611chr8:141889736ENST00000522684232863_913651053.0Compositional biasNote=Pro-rich
TgenePTK2chr4:71660611chr8:141889736ENST00000340930233422_680651066.0DomainProtein kinase
TgenePTK2chr4:71660611chr8:141889736ENST00000521059232422_680651053.0DomainProtein kinase
TgenePTK2chr4:71660611chr8:141889736ENST00000522684232422_680651053.0DomainProtein kinase
TgenePTK2chr4:71660611chr8:141889736ENST00000340930233428_434651066.0Nucleotide bindingATP
TgenePTK2chr4:71660611chr8:141889736ENST00000340930233500_502651066.0Nucleotide bindingATP
TgenePTK2chr4:71660611chr8:141889736ENST00000521059232428_434651053.0Nucleotide bindingATP
TgenePTK2chr4:71660611chr8:141889736ENST00000521059232500_502651053.0Nucleotide bindingATP
TgenePTK2chr4:71660611chr8:141889736ENST00000522684232428_434651053.0Nucleotide bindingATP
TgenePTK2chr4:71660611chr8:141889736ENST00000522684232500_502651053.0Nucleotide bindingATP

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneRUFY3chr4:71660611chr8:141889736ENST00000226328+113267_4640470.0Coiled coilOntology_term=ECO:0000255
HgeneRUFY3chr4:71660611chr8:141889736ENST00000417478+112267_4640507.0Coiled coilOntology_term=ECO:0000255
HgeneRUFY3chr4:71660611chr8:141889736ENST00000226328+11395_2270470.0DomainRUN
HgeneRUFY3chr4:71660611chr8:141889736ENST00000417478+11295_2270507.0DomainRUN
TgenePTK2chr4:71660611chr8:141889736ENST0000034093023335_355651066.0DomainFERM
TgenePTK2chr4:71660611chr8:141889736ENST0000052105923235_355651053.0DomainFERM
TgenePTK2chr4:71660611chr8:141889736ENST0000052268423235_355651053.0DomainFERM


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Fusion Gene Sequence for RUFY3-PTK2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>78627_78627_1_RUFY3-PTK2_RUFY3_chr4_71660611_ENST00000381006_PTK2_chr8_141889736_ENST00000522684_length(transcript)=6666nt_BP=2136nt
CTGCTTACTGCGCACGGCCAATCCTATGAGAACTCAGCATCCCAGCTCATCTGAGCAGATCCTGGAAGTGATTTCTGCAGCTCAGGATTT
TTTTTTTAAGCTACATTGAAAATATAGGTTTATTTTTTGTTCAGGTTTTTCTTTTATATTTTTTTTCTGCACAAAGGAGGAGGATTTTTC
ACTTACTCATATCGAGGCCAGATTTTTAAAGCCAGCTAAGGCAGCATCAGCTGTGCGGGATTTAAAGCCTATAGCTCAGCTGAAAAAAAA
GGTGGGGGGCAGGGAAGGGAAGATAAAAGGAGAGGAAGCTGGGAGAAGACAAGCATCATCTTATTTTGCTATGTGGTAGGAACTGTCTAT
AAGATAGTGTAGAATTGTTTATCTTGAGCAGTTTGTTCTTAACCTATAAGGTATTTTTCCTTTTTTTTTTTTTTAAACCTCCCCCACCCT
TTTCCTGAAAGCTTTGTTTCAGAGCTTTGTATTGGGTTTTTTTGGTGAGGAGGTTGTATTTATTTTTTTGGTGTGTGTGTGTGAGTGTGT
GTGTGTCTGTGTGTGTGTTGTGGTCCCAGCTGAGTCATCATGTCTGCTCTGACGCCTCCGACCGATATGCCAACCCCCACCACTGACAAG
ATCACACAGGCTGCCATGGAGACCATCTACCTTTGCAAATTCCGAGTGTCCATGGATGGAGAATGGCTCTGCCTGCGAGAGCTGGATGAC
ATCTCACTTACACCTGACCCAGAGCCTACCCATGAAGATCCTAATTATCTCATGGCTAATGAACGCATGAACCTCATGAACATGGCCAAG
CTGAGTATCAAGGGCTTGATTGAATCAGCTCTGAACCTGGGGAGGACTCTTGACTCTGACTATGCACCTCTCCAGCAATTCTTTGTGGTG
ATGGAGCACTGTCTGAAACATGGCTTGAAAGCTAAAAAAACTTTTCTCGGACAAAATAAATCCTTCTGGGGGCCTCTAGAACTGGTAGAA
AAGCTTGTTCCAGAAGCCGCAGAGATAACAGCAAGTGTTAAAGATCTTCCAGGACTTAAGACACCAGTAGGTAGAGGAAGAGCCTGGCTT
CGTTTGGCATTAATGCAAAAGAAACTTTCAGAATATATGAAAGCTTTGATCAATAAGAAAGAACTTCTCAGTGAATTCTACGAACCCAAT
GCCCTCATGATGGAAGAAGAAGGAGCCATAATTGCTGGTCTGTTGGTGGGTCTGAATGTCATTGATGCCAATTTCTGTATGAAAGGAGAA
GACTTGGACTCTCAGGTTGGAGTTATAGATTTTTCAATGTATCTCAAGGACGGGAACAGCAGTAAAGGTACTGAAGGAGACGGTCAGATT
ACTGCAATTCTGGACCAGAAGAACTATGTAGAAGAACTGAACAGACATTTGAATGCTACTGTAAACAACCTTCAGGCAAAAGTAGATGCA
TTAGAAAAATCCAACACTAAACTGACAGAGGAGCTTGCAGTTGCAAACAACAGGATCATTACCTTACAAGAAGAAATGGAACGAGTTAAA
GAGGAAAGTTCCTACATACTGGAATCCAATCGGAAGGGTCCCAAGCAAGACAGAACTGCAGAAGGGCAAGCACTAAGTGAAGCAAGAAAG
CATTTAAAAGAAGAGACACAATTACGATTGGATGTTGAGAAAGAACTGGAGATGCAGATCAGCATGAGGCAGGAGATGGAATTGGCTATG
AAGATGCTGGAGAAGGATGTCTGTGAGAAGCAGGATGCCCTGGTATCTCTTCGGCAGCAGCTGGATGACCTCAGAGCTCTCAAGCATGAA
CTTGCCTTTAAGCTGCAGAGTTCAGACTTAGGAGTAAAACAGAAAAGTGAACTAAACAGTCGCTTGGAAGAGAAGACTAATCAGATGGCT
GCTACCATTAAACAACTTGAACAAAGATTGCGCCAGGCTGAGCGAAGCCGCCAATCTGCTGAGTTGGACAACCGGCTCTTCAAACAGGAC
TTTGGAGACAAGATCAACAGTCTGCAGCTGGAAGTCGAGGAGCTCACCAGGCAGCGGAACCAGCTTGAGTTAGAACTAAAACAGGAAAAA
GAAAGAAGATTACAAAACGACAGGAGCATCCCAGGAAGGGGTTCCCAGAAGTCAGAATCCAAGATGGGCATCATTCAGAAGATAGTGGAC
AGTCACAAAGTAAAGCATGTGGCCTGCTATGGATTCCGCCTCAGTCACCTGCGGTCAGAGGAGGTTCACTGGCTTCACGTGGATATGGGC
GTCTCCAGTGTGAGGGAGAAGTATGAGCTTGCTCACCCACCAGAGGAGTGGAAATATGAATTGAGAATTCGTTATTTGCCAAAAGGATTT
CTAAACCAGTTTACTGAAGATAAGCCAACTTTGAATTTCTTCTATCAACAGGTGAAGAGCGATTATATGTTAGAGATAGCTGATCAAGTG
GACCAGGAAATTGCTTTGAAGTTGGGTTGTCTAGAAATACGGCGATCATACTGGGAGATGCGGGGCAATGCACTAGAAAAGAAGTCTAAC
TATGAAGTATTAGAAAAAGATGTTGGTTTAAAGCGATTTTTTCCTAAGAGTTTACTGGATTCTGTCAAGGCCAAAACACTAAGAAAACTG
ATCCAACAAACATTTAGACAATTTGCCAACCTTAATAGAGAAGAAAGTATTCTGAAATTCTTTGAGATCCTGTCTCCAGTCTACAGATTT
GATAAGGAATGCTTCAAGTGTGCTCTTGGTTCAAGCTGGATTATTTCAGTGGAACTGGCAATCGGCCCAGAAGAAGGAATCAGTTACCTA
ACGGACAAGGGCTGCAATCCCACACATCTTGCTGACTTCACTCAAGTGCAAACCATTCAGTATTCAAACAGTGAAGACAAGGACAGAAAA
GGAATGCTACAACTAAAAATAGCAGGTGCACCCGAGCCTCTGACAGTGACGGCACCATCCCTAACCATTGCGGAGAATATGGCTGACCTA
ATAGATGGGTACTGCCGGCTGGTGAATGGAACCTCGCAGTCATTTATCATCAGACCTCAGAAAGAAGGTGAACGGGCTTTGCCATCAATA
CCAAAGTTGGCCAACAGCGAAAAGCAAGGCATGCGGACACACGCCGTCTCTGTGTCAGAAACAGATGATTATGCTGAGATTATAGATGAA
GAAGATACTTACACCATGCCCTCAACCAGGGATTATGAGATTCAAAGAGAAAGAATAGAACTTGGACGATGTATTGGAGAAGGCCAATTT
GGAGATGTACATCAAGGCATTTATATGAGTCCAGAGAATCCAGCTTTGGCGGTTGCAATTAAAACATGTAAAAACTGTACTTCGGACAGC
GTGAGAGAGAAATTTCTTCAAGAAGCCTTAACAATGCGTCAGTTTGACCATCCTCATATTGTGAAGCTGATTGGAGTCATCACAGAGAAT
CCTGTCTGGATAATCATGGAGCTGTGCACACTTGGAGAGCTGAGGTCATTTTTGCAAGTAAGGAAATACAGTTTGGATCTAGCATCTTTG
ATCCTGTATGCCTATCAGCTTAGTACAGCTCTTGCATATCTAGAGAGCAAAAGATTTGTACACAGGGACATTGCTGCTCGGAATGTTCTG
GTGTCCTCAAATGATTGTGTAAAATTAGGAGACTTTGGATTATCCCGATATATGGAAGATAGTACTTACTACAAAGCTTCCAAAGGAAAA
TTGCCTATTAAATGGATGGCTCCAGAGTCAATCAATTTTCGACGTTTTACCTCAGCTAGTGACGTATGGATGTTTGGTGTGTGTATGTGG
GAGATACTGATGCATGGTGTGAAGCCTTTTCAAGGAGTGAAGAACAATGATGTAATCGGTCGAATTGAAAATGGGGAAAGATTACCAATG
CCTCCAAATTGTCCTCCTACCCTCTACAGCCTTATGACGAAATGCTGGGCCTATGACCCCAGCAGGCGGCCCAGGTTTACTGAACTTAAA
GCTCAGCTCAGCACAATCCTGGAGGAAGAGAAGGCTCAGCAAGAAGAGCGCATGAGGATGGAGTCCAGAAGACAGGCCACAGTGTCCTGG
GACTCCGGAGGGTCTGATGAAGCACCGCCCAAGCCCAGCAGACCGGGTTATCCCAGTCCGAGGTCCAGCGAAGGATTTTATCCCAGCCCA
CAGCACATGGTACAAACCAATCATTACCAGGTTTCTGGCTACCCTGGTTCACATGGAATCACAGCCATGGCTGGCAGCATCTATCCAGGT
CAGGCATCTCTTTTGGACCAAACAGATTCATGGAATCATAGACCTCAGGAGATAGCAATGTGGCAGCCCAATGTGGAGGACTCTACAGTA
TTGGACCTGCGAGGGATTGGGCAAGTGTTGCCAACCCATCTGATGGAAGAGCGTCTAATCCGACAGCAACAGGAAATGGAAGAAGATCAG
CGCTGGCTGGAAAAAGAGGAAAGATTTCTGAAACCTGATGTGAGACTCTCTCGAGGCAGTATTGACAGGGAGGATGGAAGTCTTCAGGGT
CCGATTGGAAACCAACATATATATCAGCCTGTGGGTAAACCAGATCCTGCAGCTCCACCAAAGAAACCGCCTCGCCCTGGAGCTCCCGGT
CATCTGGGAAGCCTTGCCAGCCTCAGCAGCCCTGCTGACAGCTACAACGAGGGTGTCAAGCTTCAGCCCCAGGAAATCAGCCCCCCTCCT
ACTGCCAACCTGGACCGGTCGAATGATAAGGTGTACGAGAATGTGACGGGCCTGGTGAAAGCTGTCATCGAGATGTCCAGTAAAATCCAG
CCAGCCCCACCAGAGGAGTATGTCCCTATGGTGAAGGAAGTCGGCTTGGCCCTGAGGACATTATTGGCCACTGTGGATGAGACCATTCCC
CTCCTACCAGCCAGCACCCACCGAGAGATTGAGATGGCACAGAAGCTATTGAACTCTGACCTGGGTGAGCTCATCAACAAGATGAAACTG
GCCCAGCAGTATGTCATGACCAGCCTCCAGCAAGAGTACAAAAAGCAAATGCTGACTGCTGCTCACGCCCTGGCTGTGGATGCCAAAAAC
TTACTCGATGTCATTGACCAAGCAAGACTGAAAATGCTTGGGCAGACGAGACCACACTGAGCCTCCCCTAGGAGCACGTCTTGCTACCCT
CTTTTGAAGATGTTCTCTAGCCTTCCACCAGCAGCGAGGAATTAACCCTGTGTCCTCAGTCGCCAGCACTTACAGCTCCAACTTTTTTGA
ATGACCATCTGGTTGAAAAATCTTTCTCATATAAGTTTAACCACACTTTGATTTGGGTTCATTTTTTGTTTTGTTTTTTTCAATCATGAT
ATTCAGAAAAATCCAGGATCCAAAATGTGGCGTTTTTCTAAGAATGAAAATTATATGTAAGCTTTTAAGCATCATGAAGAACAATTTATG
TTCACATTAAGATACGTTCTAAAGGGGGATGGCCAAGGGGTGACATCTTAATTCCTAAACTACCTTAGCTGCATAGTGGAAGAGGAGAGC
ATGAAGCAAAGAATTCCAGGAAACCCAAGAGGCTGAGAATTCTTTTGTCTACCATAGAATTATTATCCAGACTGGAATTTTTGTTTGTTA
GAACACCCTTCAGTTGCAATATGCTAATCCCACTTTACAAAGAATATAAAAGCTATATTTTGAAGACTTGAGTTATTTCAGAAAAAACTA
CAGCCCTTTTTGTCTTACCTGCCTTTTACTTTCGTGTGGATATGTGAAGCATTGGGTCGGGAACTAGCTGTAGAACACAACTAAAAACTC
ATGTCTTTTTTCACAGAATAATGTGCCAGTTTTTTGTAGCAATGTTATTTCTCTTGGAAGCAGAAATGCTTTGTACCAGAGCACCTCCAA
ACTGCATTGAGGAGAAGTTCCAGAACCATCCCCTTTTTCCATTTTTATATAATTTATAAAGAAAGATTAAAGCCATGTTGACTATTTTAC
AGCCACTGGAGTTAACTAACCCTTCCTTGTATCTGTCTTCCCAGGAGAGAATGAAGCAAAACAGGAATTTGGTTTTCTTTTGATGTCCAG
TTACACCATCCATTCTGTTAATTTTGAAAAAATATACCCTCCCTTTAGTTTGTTGGGGGATATAAATTATTCTCAGGAAGAATATAATGA
ACTGTACAGTTACTTTGACCTATTAAAAAGGTGTTACCAGTAAAGTTCTTGTTGTAATATCCTTTCTTTTGGTTCTGTTTCTTCAGATGG
CTTTTCAGGTGACTTGTCAGATAAGATAACATACAAGAGAGTTCCCAATAATTATCAGGAAGCCTCTCACTAATTAGTTTCTTTTTTTTT
ATTTAATCTTCTAAACAAGTCAAGGATGTTACCACAGAAGGGTAGCGTGGCGTAAGTTAACCTTTTCATTCCATCGTCACCTATTAAATG
CAGAGCTCAGGATGGAAGTAGCAATGGTCTTCAATGAAAGAACCTTCCCCTGCGCAGGGTCTCACTATTCCGCTAACTCGGACTCAAAGC
ATAATTCACTTGTCAAGGAAATTGTTAGCATTTCCCAGGCCCACCCTAGTCTTGCTAGAATCTCTGTGAGCCACAGAGCAGGGAGCAAAT
AGAACTGAGATCTCCAGCACTAGGGACTCAGACTCCAAAGGGAGGGATTTGAGTGAATTTTTTCCAGGTAAATACATGCTCTTATGTGCA

>78627_78627_1_RUFY3-PTK2_RUFY3_chr4_71660611_ENST00000381006_PTK2_chr8_141889736_ENST00000522684_length(amino acids)=1506AA_BP=519
MSALTPPTDMPTPTTDKITQAAMETIYLCKFRVSMDGEWLCLRELDDISLTPDPEPTHEDPNYLMANERMNLMNMAKLSIKGLIESALNL
GRTLDSDYAPLQQFFVVMEHCLKHGLKAKKTFLGQNKSFWGPLELVEKLVPEAAEITASVKDLPGLKTPVGRGRAWLRLALMQKKLSEYM
KALINKKELLSEFYEPNALMMEEEGAIIAGLLVGLNVIDANFCMKGEDLDSQVGVIDFSMYLKDGNSSKGTEGDGQITAILDQKNYVEEL
NRHLNATVNNLQAKVDALEKSNTKLTEELAVANNRIITLQEEMERVKEESSYILESNRKGPKQDRTAEGQALSEARKHLKEETQLRLDVE
KELEMQISMRQEMELAMKMLEKDVCEKQDALVSLRQQLDDLRALKHELAFKLQSSDLGVKQKSELNSRLEEKTNQMAATIKQLEQRLRQA
ERSRQSAELDNRLFKQDFGDKINSLQLEVEELTRQRNQLELELKQEKERRLQNDRSIPGRGSQKSESKMGIIQKIVDSHKVKHVACYGFR
LSHLRSEEVHWLHVDMGVSSVREKYELAHPPEEWKYELRIRYLPKGFLNQFTEDKPTLNFFYQQVKSDYMLEIADQVDQEIALKLGCLEI
RRSYWEMRGNALEKKSNYEVLEKDVGLKRFFPKSLLDSVKAKTLRKLIQQTFRQFANLNREESILKFFEILSPVYRFDKECFKCALGSSW
IISVELAIGPEEGISYLTDKGCNPTHLADFTQVQTIQYSNSEDKDRKGMLQLKIAGAPEPLTVTAPSLTIAENMADLIDGYCRLVNGTSQ
SFIIRPQKEGERALPSIPKLANSEKQGMRTHAVSVSETDDYAEIIDEEDTYTMPSTRDYEIQRERIELGRCIGEGQFGDVHQGIYMSPEN
PALAVAIKTCKNCTSDSVREKFLQEALTMRQFDHPHIVKLIGVITENPVWIIMELCTLGELRSFLQVRKYSLDLASLILYAYQLSTALAY
LESKRFVHRDIAARNVLVSSNDCVKLGDFGLSRYMEDSTYYKASKGKLPIKWMAPESINFRRFTSASDVWMFGVCMWEILMHGVKPFQGV
KNNDVIGRIENGERLPMPPNCPPTLYSLMTKCWAYDPSRRPRFTELKAQLSTILEEEKAQQEERMRMESRRQATVSWDSGGSDEAPPKPS
RPGYPSPRSSEGFYPSPQHMVQTNHYQVSGYPGSHGITAMAGSIYPGQASLLDQTDSWNHRPQEIAMWQPNVEDSTVLDLRGIGQVLPTH
LMEERLIRQQQEMEEDQRWLEKEERFLKPDVRLSRGSIDREDGSLQGPIGNQHIYQPVGKPDPAAPPKKPPRPGAPGHLGSLASLSSPAD
SYNEGVKLQPQEISPPPTANLDRSNDKVYENVTGLVKAVIEMSSKIQPAPPEEYVPMVKEVGLALRTLLATVDETIPLLPASTHREIEMA

--------------------------------------------------------------
>78627_78627_2_RUFY3-PTK2_RUFY3_chr4_71660611_ENST00000381006_PTK2_chr8_141889736_ENST00000535192_length(transcript)=6037nt_BP=2136nt
CTGCTTACTGCGCACGGCCAATCCTATGAGAACTCAGCATCCCAGCTCATCTGAGCAGATCCTGGAAGTGATTTCTGCAGCTCAGGATTT
TTTTTTTAAGCTACATTGAAAATATAGGTTTATTTTTTGTTCAGGTTTTTCTTTTATATTTTTTTTCTGCACAAAGGAGGAGGATTTTTC
ACTTACTCATATCGAGGCCAGATTTTTAAAGCCAGCTAAGGCAGCATCAGCTGTGCGGGATTTAAAGCCTATAGCTCAGCTGAAAAAAAA
GGTGGGGGGCAGGGAAGGGAAGATAAAAGGAGAGGAAGCTGGGAGAAGACAAGCATCATCTTATTTTGCTATGTGGTAGGAACTGTCTAT
AAGATAGTGTAGAATTGTTTATCTTGAGCAGTTTGTTCTTAACCTATAAGGTATTTTTCCTTTTTTTTTTTTTTAAACCTCCCCCACCCT
TTTCCTGAAAGCTTTGTTTCAGAGCTTTGTATTGGGTTTTTTTGGTGAGGAGGTTGTATTTATTTTTTTGGTGTGTGTGTGTGAGTGTGT
GTGTGTCTGTGTGTGTGTTGTGGTCCCAGCTGAGTCATCATGTCTGCTCTGACGCCTCCGACCGATATGCCAACCCCCACCACTGACAAG
ATCACACAGGCTGCCATGGAGACCATCTACCTTTGCAAATTCCGAGTGTCCATGGATGGAGAATGGCTCTGCCTGCGAGAGCTGGATGAC
ATCTCACTTACACCTGACCCAGAGCCTACCCATGAAGATCCTAATTATCTCATGGCTAATGAACGCATGAACCTCATGAACATGGCCAAG
CTGAGTATCAAGGGCTTGATTGAATCAGCTCTGAACCTGGGGAGGACTCTTGACTCTGACTATGCACCTCTCCAGCAATTCTTTGTGGTG
ATGGAGCACTGTCTGAAACATGGCTTGAAAGCTAAAAAAACTTTTCTCGGACAAAATAAATCCTTCTGGGGGCCTCTAGAACTGGTAGAA
AAGCTTGTTCCAGAAGCCGCAGAGATAACAGCAAGTGTTAAAGATCTTCCAGGACTTAAGACACCAGTAGGTAGAGGAAGAGCCTGGCTT
CGTTTGGCATTAATGCAAAAGAAACTTTCAGAATATATGAAAGCTTTGATCAATAAGAAAGAACTTCTCAGTGAATTCTACGAACCCAAT
GCCCTCATGATGGAAGAAGAAGGAGCCATAATTGCTGGTCTGTTGGTGGGTCTGAATGTCATTGATGCCAATTTCTGTATGAAAGGAGAA
GACTTGGACTCTCAGGTTGGAGTTATAGATTTTTCAATGTATCTCAAGGACGGGAACAGCAGTAAAGGTACTGAAGGAGACGGTCAGATT
ACTGCAATTCTGGACCAGAAGAACTATGTAGAAGAACTGAACAGACATTTGAATGCTACTGTAAACAACCTTCAGGCAAAAGTAGATGCA
TTAGAAAAATCCAACACTAAACTGACAGAGGAGCTTGCAGTTGCAAACAACAGGATCATTACCTTACAAGAAGAAATGGAACGAGTTAAA
GAGGAAAGTTCCTACATACTGGAATCCAATCGGAAGGGTCCCAAGCAAGACAGAACTGCAGAAGGGCAAGCACTAAGTGAAGCAAGAAAG
CATTTAAAAGAAGAGACACAATTACGATTGGATGTTGAGAAAGAACTGGAGATGCAGATCAGCATGAGGCAGGAGATGGAATTGGCTATG
AAGATGCTGGAGAAGGATGTCTGTGAGAAGCAGGATGCCCTGGTATCTCTTCGGCAGCAGCTGGATGACCTCAGAGCTCTCAAGCATGAA
CTTGCCTTTAAGCTGCAGAGTTCAGACTTAGGAGTAAAACAGAAAAGTGAACTAAACAGTCGCTTGGAAGAGAAGACTAATCAGATGGCT
GCTACCATTAAACAACTTGAACAAAGATTGCGCCAGGCTGAGCGAAGCCGCCAATCTGCTGAGTTGGACAACCGGCTCTTCAAACAGGAC
TTTGGAGACAAGATCAACAGTCTGCAGCTGGAAGTCGAGGAGCTCACCAGGCAGCGGAACCAGCTTGAGTTAGAACTAAAACAGGAAAAA
GAAAGAAGATTACAAAACGACAGGAGCATCCCAGGAAGGGGTTCCCAGAAGTCAGAATCCAAGATGGGCATCATTCAGAAGATAGTGGAC
AGTCACAAAGTAAAGCATGTGGCCTGCTATGGATTCCGCCTCAGTCACCTGCGGTCAGAGGAGGTTCACTGGCTTCACGTGGATATGGGC
GTCTCCAGTGTGAGGGAGAAGTATGAGCTTGCTCACCCACCAGAGGAGTGGAAATATGAATTGAGAATTCGTTATTTGCCAAAAGGATTT
CTAAACCAGTTTACTGAAGATAAGCCAACTTTGAATTTCTTCTATCAACAGGTGAAGAGCGATTATATGTTAGAGATAGCTGATCAAGTG
GACCAGGAAATTGCTTTGAAGTTGGGTTGTCTAGAAATACGGCGATCATACTGGGAGATGCGGGGCAATGCACTAGAAAAGAAGTCTAAC
TATGAAGTATTAGAAAAAGATGTTGGTTTAAAGCGATTTTTTCCTAAGAGTTTACTGGATTCTGTCAAGGCCAAAACACTAAGAAAACTG
ATCCAACAAACATTTAGACAATTTGCCAACCTTAATAGAGAAGAAAGTATTCTGAAATTCTTTGAGATCCTGTCTCCAGTCTACAGATTT
GATAAGGAATGCTTCAAGTGTGCTCTTGGTTCAAGCTGGATTATTTCAGTGGAACTGGCAATCGGCCCAGAAGAAGGAATCAGTTACCTA
ACGGACAAGGGCTGCAATCCCACACATCTTGCTGACTTCACTCAAGTGCAAACCATTCAGTATTCAAACAGTGAAGACAAGGACAGAAAA
GGAATGCTACAACTAAAAATAGCAGGTGCACCCGAGCCTCTGACAGTGACGGCACCATCCCTAACCATTGCGGAGAATATGGCTGACCTA
ATAGATGGGTACTGCCGGCTGGTGAATGGAACCTCGCAGTCATTTATCATCAGACCTCAGAAAGAAGGTGAACGGGCTTTGCCATCAATA
CCAAAGTTGGCCAACAGCGAAAAGCAAGGCATGCGGACACACGCCGTCTCTGTGTCAGAAACAGATGATTATGCTGAGATTATAGATGAA
GAAGATACTTACACCATGCCCTCAACCAGGGATTATGAGATTCAAAGAGAAAGAATAGAACTTGGACGATGTATTGGAGAAGGCCAATTT
GGAGATGTACATCAAGGCATTTATATGAGTCCAGAGAATCCAGCTTTGGCGGTTGCAATTAAAACATGTAAAAACTGTACTTCGGACAGC
GTGAGAGAGAAATTTCTTCAAGAAGCCTTAACAATGCGTCAGTTTGACCATCCTCATATTGTGAAGCTGATTGGAGTCATCACAGAGAAT
CCTGTCTGGATAATCATGGAGCTGTGCACACTTGGAGAGCTGAGGTCATTTTTGCAAGTAAGGAAATACAGTTTGGATCTAGCATCTTTG
ATCCTGTATGCCTATCAGCTTAGTACAGCTCTTGCATATCTAGAGAGCAAAAGATTTGTACACAGGGACATTGCTGCTCGGAATGTTCTG
GTGTCCTCAAATGATTGTGTAAAATTAGGAGACTTTGGATTATCCCGATATATGGAAGATAGTACTTACTACAAAGCTTCCAAAGGAAAA
TTGCCTATTAAATGGATGGCTCCAGAGTCAATCAATTTTCGACGTTTTACCTCAGCTAGTGACGTATGGATGTTTGGTGTGTGTATGTGG
GAGATACTGATGCATGGTGTGAAGCCTTTTCAAGGAGTGAAGAACAATGATGTAATCGGTCGAATTGAAAATGGGGAAAGATTACCAATG
CCTCCAAATTGTCCTCCTACCCTCTACAGCCTTATGACGAAATGCTGGGCCTATGACCCCAGCAGGCGGCCCAGGTTTACTGAACTTAAA
GCTCAGCTCAGCACAATCCTGGAGGAAGAGAAGGCTCAGCAAGAAGAGCGCATGAGGATGGAGTCCAGAAGACAGGCCACAGTGTCCTGG
GACTCCGGAGGGTCTGATGAAGCACCGCCCAAGCCCAGCAGACCGGGTTATCCCAGTCCGAGGTCCAGCGAAGGATTTTATCCCAGCCCA
CAGCACATGGTACAAACCAATCATTACCAGGACTCTACAGTATTGGACCTGCGAGGGATTGGGCAAGTGTTGCCAACCCATCTGATGGAA
GAGCGTCTAATCCGACAGCAACAGGAAATGGAAGAAGATCAGCGCTGGCTGGAAAAAGAGGAAAGATTTCTGAAACCTGATGTGAGACTC
TCTCGAGGCAGTATTGACAGGGAGGATGGAAGTCTTCAGGGTCCGATTGGAAACCAACATATATATCAGCCTGTGGGTAAACCAGATCCT
GCAGCTCCACCAAAGAAACCGCCTCGCCCTGGAGCTCCCGGTCATCTGGGAAGCCTTGCCAGCCTCAGCAGCCCTGCTGACAGCTACAAC
GAGGGTGTCAAGCTTCAGCCCCAGGAAATCAGCCCCCCTCCTACTGCCAACCTGGACCGGTCGAATGATAAGGTGTACGAGAATGTGACG
GGCCTGGTGAAAGCTGTCATCGAGATGTCCAGTAAAATCCAGCCAGCCCCACCAGAGGAGTATGTCCCTATGGTGAAGGAAGTCGGCTTG
GCCCTGAGGACATTATTGGCCACTGTGGATGAGACCATTCCCCTCCTACCAGCCAGCACCCACCGAGAGATTGAGATGGCACAGAAGCTA
TTGAACTCTGACCTGGGTGAGCTCATCAACAAGATGAAACTGGCCCAGCAGTATGTCATGACCAGCCTCCAGCAAGAGTACAAAAAGCAA
ATGCTGACTGCTGCTCACGCCCTGGCTGTGGATGCCAAAAACTTACTCGATGTCATTGACCAAGCAAGACTGAAAATGCTTGGGCAGACG
AGACCACACTGAGCCTCCCCTAGGAGCACGTCTTGCTACCCTCTTTTGAAGATGTTCTCTAGCCTTCCACCAGCAGCGAGGAATTAACCC
TGTGTCCTCAGTCGCCAGCACTTACAGCTCCAACTTTTTTGAATGACCATCTGGTTGAAAAATCTTTCTCATATAAGTTTAACCACACTT
TGATTTGGGTTCATTTTTTGTTTTGTTTTTTTCAATCATGATATTCAGAAAAATCCAGGATCCAAAATGTGGCGTTTTTCTAAGAATGAA
AATTATATGTAAGCTTTTAAGCATCATGAAGAACAATTTATGTTCACATTAAGATACGTTCTAAAGGGGGATGGCCAAGGGGTGACATCT
TAATTCCTAAACTACCTTAGCTGCATAGTGGAAGAGGAGAGCATGAAGCAAAGAATTCCAGGAAACCCAAGAGGCTGAGAATTCTTTTGT
CTACCATAGAATTATTATCCAGACTGGAATTTTTGTTTGTTAGAACACCCTTCAGTTGCAATATGCTAATCCCACTTTACAAAGAATATA
AAAGCTATATTTTGAAGACTTGAGTTATTTCAGAAAAAACTACAGCCCTTTTTGTCTTACCTGCCTTTTACTTTCGTGTGGATATGTGAA
GCATTGGGTCGGGAACTAGCTGTAGAACACAACTAAAAACTCATGTCTTTTTTCACAGAATAATGTGCCAGTTTTTTGTAGCAATGTTAT
TTCTCTTGGAAGCAGAAATGCTTTGTACCAGAGCACCTCCAAACTGCATTGAGGAGAAGTTCCAGAACCATCCCCTTTTTCCATTTTTAT
ATAATTTATAAAGAAAGATTAAAGCCATGTTGACTATTTTACAGCCACTGGAGTTAACTAACCCTTCCTTGTATCTGTCTTCCCAGGAGA
GAATGAAGCAAAACAGGAATTTGGTTTTCTTTTGATGTCCAGTTACACCATCCATTCTGTTAATTTTGAAAAAATATACCCTCCCTTTAG
TTTGTTGGGGGATATAAATTATTCTCAGGAAGAATATAATGAACTGTACAGTTACTTTGACCTATTAAAAAGGTGTTACCAGTAAAGTTC

>78627_78627_2_RUFY3-PTK2_RUFY3_chr4_71660611_ENST00000381006_PTK2_chr8_141889736_ENST00000535192_length(amino acids)=1460AA_BP=519
MSALTPPTDMPTPTTDKITQAAMETIYLCKFRVSMDGEWLCLRELDDISLTPDPEPTHEDPNYLMANERMNLMNMAKLSIKGLIESALNL
GRTLDSDYAPLQQFFVVMEHCLKHGLKAKKTFLGQNKSFWGPLELVEKLVPEAAEITASVKDLPGLKTPVGRGRAWLRLALMQKKLSEYM
KALINKKELLSEFYEPNALMMEEEGAIIAGLLVGLNVIDANFCMKGEDLDSQVGVIDFSMYLKDGNSSKGTEGDGQITAILDQKNYVEEL
NRHLNATVNNLQAKVDALEKSNTKLTEELAVANNRIITLQEEMERVKEESSYILESNRKGPKQDRTAEGQALSEARKHLKEETQLRLDVE
KELEMQISMRQEMELAMKMLEKDVCEKQDALVSLRQQLDDLRALKHELAFKLQSSDLGVKQKSELNSRLEEKTNQMAATIKQLEQRLRQA
ERSRQSAELDNRLFKQDFGDKINSLQLEVEELTRQRNQLELELKQEKERRLQNDRSIPGRGSQKSESKMGIIQKIVDSHKVKHVACYGFR
LSHLRSEEVHWLHVDMGVSSVREKYELAHPPEEWKYELRIRYLPKGFLNQFTEDKPTLNFFYQQVKSDYMLEIADQVDQEIALKLGCLEI
RRSYWEMRGNALEKKSNYEVLEKDVGLKRFFPKSLLDSVKAKTLRKLIQQTFRQFANLNREESILKFFEILSPVYRFDKECFKCALGSSW
IISVELAIGPEEGISYLTDKGCNPTHLADFTQVQTIQYSNSEDKDRKGMLQLKIAGAPEPLTVTAPSLTIAENMADLIDGYCRLVNGTSQ
SFIIRPQKEGERALPSIPKLANSEKQGMRTHAVSVSETDDYAEIIDEEDTYTMPSTRDYEIQRERIELGRCIGEGQFGDVHQGIYMSPEN
PALAVAIKTCKNCTSDSVREKFLQEALTMRQFDHPHIVKLIGVITENPVWIIMELCTLGELRSFLQVRKYSLDLASLILYAYQLSTALAY
LESKRFVHRDIAARNVLVSSNDCVKLGDFGLSRYMEDSTYYKASKGKLPIKWMAPESINFRRFTSASDVWMFGVCMWEILMHGVKPFQGV
KNNDVIGRIENGERLPMPPNCPPTLYSLMTKCWAYDPSRRPRFTELKAQLSTILEEEKAQQEERMRMESRRQATVSWDSGGSDEAPPKPS
RPGYPSPRSSEGFYPSPQHMVQTNHYQDSTVLDLRGIGQVLPTHLMEERLIRQQQEMEEDQRWLEKEERFLKPDVRLSRGSIDREDGSLQ
GPIGNQHIYQPVGKPDPAAPPKKPPRPGAPGHLGSLASLSSPADSYNEGVKLQPQEISPPPTANLDRSNDKVYENVTGLVKAVIEMSSKI
QPAPPEEYVPMVKEVGLALRTLLATVDETIPLLPASTHREIEMAQKLLNSDLGELINKMKLAQQYVMTSLQQEYKKQMLTAAHALAVDAK

--------------------------------------------------------------
>78627_78627_3_RUFY3-PTK2_RUFY3_chr4_71660611_ENST00000502653_PTK2_chr8_141889736_ENST00000522684_length(transcript)=6123nt_BP=1593nt
GATTATGTGTTCAGAAGGCAGTCTCAGTGAACTTCTCAAAGTGAGAAGGTTGTAGCTTTTAATACAGTCTCAGAAGCCTATGGGACAAAG
TTTTCTGGACACGGTTCATCCCTTCTTGTTGCTCTGCCCTGAAAATAACCTGGCTAGTCACCCTTTCAAGACTCTTGGGAGGATTTGACA
GATTTGGTGGAGCAAATGCGCGATGATACAGAAGATCCTAATTATCTCATGGCTAATGAACGCATGAACCTCATGAACATGGCCAAGCTG
AGTATCAAGGGCTTGATTGAATCAGCTCTGAACCTGGGGAGGACTCTTGACTCTGACTATGCACCTCTCCAGCAATTCTTTGTGGTGATG
GAGCACTGTCTGAAACATGGCTTGAAAGCTAAAAAAACTTTTCTCGGACAAAATAAATCCTTCTGGGGGCCTCTAGAACTGGTAGAAAAG
CTTGTTCCAGAAGCCGCAGAGATAACAGCAAGTGTTAAAGATCTTCCAGGACTTAAGACACCAGTAGGTAGAGGAAGAGCCTGGCTTCGT
TTGGCATTAATGCAAAAGAAACTTTCAGAATATATGAAAGCTTTGATCAATAAGAAAGAACTTCTCAGTGAATTCTACGAACCCAATGCC
CTCATGATGGAAGAAGAAGGAGCCATAATTGCTGGTCTGTTGGTGGGTCTGAATGTCATTGATGCCAATTTCTGTATGAAAGGAGAAGAC
TTGGACTCTCAGGTTGGAGTTATAGATTTTTCAATGTATCTCAAGGACGGGAACAGCAGTAAAGGTACTGAAGGAGACGGTCAGATTACT
GCAATTCTGGACCAGAAGAACTATGTAGAAGAACTGAACAGACATTTGAATGCTACTGTAAACAACCTTCAGGCAAAAGTAGATGCATTA
GAAAAATCCAACACTAAACTGACAGAGGAGCTTGCAGTTGCAAACAACAGGATCATTACCTTACAAGAAGAAATGGAACGAGTTAAAGAG
GAAAGTTCCTACATACTGGAATCCAATCGGAAGGGTCCCAAGCAAGACAGAACTGCAGAAGGGCAAGCACTAAGTGAAGCAAGAAAGCAT
TTAAAAGAAGAGACACAATTACGATTGGATGTTGAGAAAGAACTGGAGATGCAGATCAGCATGAGGCAGGAGATGGAATTGGCTATGAAG
ATGCTGGAGAAGGATGTCTGTGAGAAGCAGGATGCCCTGGTATCTCTTCGGCAGCAGCTGGATGACCTCAGAGCTCTCAAGCATGAACTT
GCCTTTAAGCTGCAGAGTTCAGACTTAGGAGTAAAACAGAAAAGTGAACTAAACAGTCGCTTGGAAGAGAAGACTAATCAGATGGCTGCT
ACCATTAAACAACTTGAACAAAGATTGCGCCAGGCTGAGCGAAGCCGCCAATCTGCTGAGTTGGACAACCGGCTCTTCAAACAGGACTTT
GGAGACAAGATCAACAGTCTGCAGCTGGAAGTCGAGGAGCTCACCAGGCAGCGGAACCAGCTTGAGTTAGAACTAAAACAGGAAAAAGAA
AGAAGATTACAAAACGACAGGAGCATCCCAGGAAGGGGTTCCCAGAAGTCAGAATCCAAGATGGGCATCATTCAGAAGATAGTGGACAGT
CACAAAGTAAAGCATGTGGCCTGCTATGGATTCCGCCTCAGTCACCTGCGGTCAGAGGAGGTTCACTGGCTTCACGTGGATATGGGCGTC
TCCAGTGTGAGGGAGAAGTATGAGCTTGCTCACCCACCAGAGGAGTGGAAATATGAATTGAGAATTCGTTATTTGCCAAAAGGATTTCTA
AACCAGTTTACTGAAGATAAGCCAACTTTGAATTTCTTCTATCAACAGGTGAAGAGCGATTATATGTTAGAGATAGCTGATCAAGTGGAC
CAGGAAATTGCTTTGAAGTTGGGTTGTCTAGAAATACGGCGATCATACTGGGAGATGCGGGGCAATGCACTAGAAAAGAAGTCTAACTAT
GAAGTATTAGAAAAAGATGTTGGTTTAAAGCGATTTTTTCCTAAGAGTTTACTGGATTCTGTCAAGGCCAAAACACTAAGAAAACTGATC
CAACAAACATTTAGACAATTTGCCAACCTTAATAGAGAAGAAAGTATTCTGAAATTCTTTGAGATCCTGTCTCCAGTCTACAGATTTGAT
AAGGAATGCTTCAAGTGTGCTCTTGGTTCAAGCTGGATTATTTCAGTGGAACTGGCAATCGGCCCAGAAGAAGGAATCAGTTACCTAACG
GACAAGGGCTGCAATCCCACACATCTTGCTGACTTCACTCAAGTGCAAACCATTCAGTATTCAAACAGTGAAGACAAGGACAGAAAAGGA
ATGCTACAACTAAAAATAGCAGGTGCACCCGAGCCTCTGACAGTGACGGCACCATCCCTAACCATTGCGGAGAATATGGCTGACCTAATA
GATGGGTACTGCCGGCTGGTGAATGGAACCTCGCAGTCATTTATCATCAGACCTCAGAAAGAAGGTGAACGGGCTTTGCCATCAATACCA
AAGTTGGCCAACAGCGAAAAGCAAGGCATGCGGACACACGCCGTCTCTGTGTCAGAAACAGATGATTATGCTGAGATTATAGATGAAGAA
GATACTTACACCATGCCCTCAACCAGGGATTATGAGATTCAAAGAGAAAGAATAGAACTTGGACGATGTATTGGAGAAGGCCAATTTGGA
GATGTACATCAAGGCATTTATATGAGTCCAGAGAATCCAGCTTTGGCGGTTGCAATTAAAACATGTAAAAACTGTACTTCGGACAGCGTG
AGAGAGAAATTTCTTCAAGAAGCCTTAACAATGCGTCAGTTTGACCATCCTCATATTGTGAAGCTGATTGGAGTCATCACAGAGAATCCT
GTCTGGATAATCATGGAGCTGTGCACACTTGGAGAGCTGAGGTCATTTTTGCAAGTAAGGAAATACAGTTTGGATCTAGCATCTTTGATC
CTGTATGCCTATCAGCTTAGTACAGCTCTTGCATATCTAGAGAGCAAAAGATTTGTACACAGGGACATTGCTGCTCGGAATGTTCTGGTG
TCCTCAAATGATTGTGTAAAATTAGGAGACTTTGGATTATCCCGATATATGGAAGATAGTACTTACTACAAAGCTTCCAAAGGAAAATTG
CCTATTAAATGGATGGCTCCAGAGTCAATCAATTTTCGACGTTTTACCTCAGCTAGTGACGTATGGATGTTTGGTGTGTGTATGTGGGAG
ATACTGATGCATGGTGTGAAGCCTTTTCAAGGAGTGAAGAACAATGATGTAATCGGTCGAATTGAAAATGGGGAAAGATTACCAATGCCT
CCAAATTGTCCTCCTACCCTCTACAGCCTTATGACGAAATGCTGGGCCTATGACCCCAGCAGGCGGCCCAGGTTTACTGAACTTAAAGCT
CAGCTCAGCACAATCCTGGAGGAAGAGAAGGCTCAGCAAGAAGAGCGCATGAGGATGGAGTCCAGAAGACAGGCCACAGTGTCCTGGGAC
TCCGGAGGGTCTGATGAAGCACCGCCCAAGCCCAGCAGACCGGGTTATCCCAGTCCGAGGTCCAGCGAAGGATTTTATCCCAGCCCACAG
CACATGGTACAAACCAATCATTACCAGGTTTCTGGCTACCCTGGTTCACATGGAATCACAGCCATGGCTGGCAGCATCTATCCAGGTCAG
GCATCTCTTTTGGACCAAACAGATTCATGGAATCATAGACCTCAGGAGATAGCAATGTGGCAGCCCAATGTGGAGGACTCTACAGTATTG
GACCTGCGAGGGATTGGGCAAGTGTTGCCAACCCATCTGATGGAAGAGCGTCTAATCCGACAGCAACAGGAAATGGAAGAAGATCAGCGC
TGGCTGGAAAAAGAGGAAAGATTTCTGAAACCTGATGTGAGACTCTCTCGAGGCAGTATTGACAGGGAGGATGGAAGTCTTCAGGGTCCG
ATTGGAAACCAACATATATATCAGCCTGTGGGTAAACCAGATCCTGCAGCTCCACCAAAGAAACCGCCTCGCCCTGGAGCTCCCGGTCAT
CTGGGAAGCCTTGCCAGCCTCAGCAGCCCTGCTGACAGCTACAACGAGGGTGTCAAGCTTCAGCCCCAGGAAATCAGCCCCCCTCCTACT
GCCAACCTGGACCGGTCGAATGATAAGGTGTACGAGAATGTGACGGGCCTGGTGAAAGCTGTCATCGAGATGTCCAGTAAAATCCAGCCA
GCCCCACCAGAGGAGTATGTCCCTATGGTGAAGGAAGTCGGCTTGGCCCTGAGGACATTATTGGCCACTGTGGATGAGACCATTCCCCTC
CTACCAGCCAGCACCCACCGAGAGATTGAGATGGCACAGAAGCTATTGAACTCTGACCTGGGTGAGCTCATCAACAAGATGAAACTGGCC
CAGCAGTATGTCATGACCAGCCTCCAGCAAGAGTACAAAAAGCAAATGCTGACTGCTGCTCACGCCCTGGCTGTGGATGCCAAAAACTTA
CTCGATGTCATTGACCAAGCAAGACTGAAAATGCTTGGGCAGACGAGACCACACTGAGCCTCCCCTAGGAGCACGTCTTGCTACCCTCTT
TTGAAGATGTTCTCTAGCCTTCCACCAGCAGCGAGGAATTAACCCTGTGTCCTCAGTCGCCAGCACTTACAGCTCCAACTTTTTTGAATG
ACCATCTGGTTGAAAAATCTTTCTCATATAAGTTTAACCACACTTTGATTTGGGTTCATTTTTTGTTTTGTTTTTTTCAATCATGATATT
CAGAAAAATCCAGGATCCAAAATGTGGCGTTTTTCTAAGAATGAAAATTATATGTAAGCTTTTAAGCATCATGAAGAACAATTTATGTTC
ACATTAAGATACGTTCTAAAGGGGGATGGCCAAGGGGTGACATCTTAATTCCTAAACTACCTTAGCTGCATAGTGGAAGAGGAGAGCATG
AAGCAAAGAATTCCAGGAAACCCAAGAGGCTGAGAATTCTTTTGTCTACCATAGAATTATTATCCAGACTGGAATTTTTGTTTGTTAGAA
CACCCTTCAGTTGCAATATGCTAATCCCACTTTACAAAGAATATAAAAGCTATATTTTGAAGACTTGAGTTATTTCAGAAAAAACTACAG
CCCTTTTTGTCTTACCTGCCTTTTACTTTCGTGTGGATATGTGAAGCATTGGGTCGGGAACTAGCTGTAGAACACAACTAAAAACTCATG
TCTTTTTTCACAGAATAATGTGCCAGTTTTTTGTAGCAATGTTATTTCTCTTGGAAGCAGAAATGCTTTGTACCAGAGCACCTCCAAACT
GCATTGAGGAGAAGTTCCAGAACCATCCCCTTTTTCCATTTTTATATAATTTATAAAGAAAGATTAAAGCCATGTTGACTATTTTACAGC
CACTGGAGTTAACTAACCCTTCCTTGTATCTGTCTTCCCAGGAGAGAATGAAGCAAAACAGGAATTTGGTTTTCTTTTGATGTCCAGTTA
CACCATCCATTCTGTTAATTTTGAAAAAATATACCCTCCCTTTAGTTTGTTGGGGGATATAAATTATTCTCAGGAAGAATATAATGAACT
GTACAGTTACTTTGACCTATTAAAAAGGTGTTACCAGTAAAGTTCTTGTTGTAATATCCTTTCTTTTGGTTCTGTTTCTTCAGATGGCTT
TTCAGGTGACTTGTCAGATAAGATAACATACAAGAGAGTTCCCAATAATTATCAGGAAGCCTCTCACTAATTAGTTTCTTTTTTTTTATT
TAATCTTCTAAACAAGTCAAGGATGTTACCACAGAAGGGTAGCGTGGCGTAAGTTAACCTTTTCATTCCATCGTCACCTATTAAATGCAG
AGCTCAGGATGGAAGTAGCAATGGTCTTCAATGAAAGAACCTTCCCCTGCGCAGGGTCTCACTATTCCGCTAACTCGGACTCAAAGCATA
ATTCACTTGTCAAGGAAATTGTTAGCATTTCCCAGGCCCACCCTAGTCTTGCTAGAATCTCTGTGAGCCACAGAGCAGGGAGCAAATAGA
ACTGAGATCTCCAGCACTAGGGACTCAGACTCCAAAGGGAGGGATTTGAGTGAATTTTTTCCAGGTAAATACATGCTCTTATGTGCAAAA

>78627_78627_3_RUFY3-PTK2_RUFY3_chr4_71660611_ENST00000502653_PTK2_chr8_141889736_ENST00000522684_length(amino acids)=1460AA_BP=473
MTDLVEQMRDDTEDPNYLMANERMNLMNMAKLSIKGLIESALNLGRTLDSDYAPLQQFFVVMEHCLKHGLKAKKTFLGQNKSFWGPLELV
EKLVPEAAEITASVKDLPGLKTPVGRGRAWLRLALMQKKLSEYMKALINKKELLSEFYEPNALMMEEEGAIIAGLLVGLNVIDANFCMKG
EDLDSQVGVIDFSMYLKDGNSSKGTEGDGQITAILDQKNYVEELNRHLNATVNNLQAKVDALEKSNTKLTEELAVANNRIITLQEEMERV
KEESSYILESNRKGPKQDRTAEGQALSEARKHLKEETQLRLDVEKELEMQISMRQEMELAMKMLEKDVCEKQDALVSLRQQLDDLRALKH
ELAFKLQSSDLGVKQKSELNSRLEEKTNQMAATIKQLEQRLRQAERSRQSAELDNRLFKQDFGDKINSLQLEVEELTRQRNQLELELKQE
KERRLQNDRSIPGRGSQKSESKMGIIQKIVDSHKVKHVACYGFRLSHLRSEEVHWLHVDMGVSSVREKYELAHPPEEWKYELRIRYLPKG
FLNQFTEDKPTLNFFYQQVKSDYMLEIADQVDQEIALKLGCLEIRRSYWEMRGNALEKKSNYEVLEKDVGLKRFFPKSLLDSVKAKTLRK
LIQQTFRQFANLNREESILKFFEILSPVYRFDKECFKCALGSSWIISVELAIGPEEGISYLTDKGCNPTHLADFTQVQTIQYSNSEDKDR
KGMLQLKIAGAPEPLTVTAPSLTIAENMADLIDGYCRLVNGTSQSFIIRPQKEGERALPSIPKLANSEKQGMRTHAVSVSETDDYAEIID
EEDTYTMPSTRDYEIQRERIELGRCIGEGQFGDVHQGIYMSPENPALAVAIKTCKNCTSDSVREKFLQEALTMRQFDHPHIVKLIGVITE
NPVWIIMELCTLGELRSFLQVRKYSLDLASLILYAYQLSTALAYLESKRFVHRDIAARNVLVSSNDCVKLGDFGLSRYMEDSTYYKASKG
KLPIKWMAPESINFRRFTSASDVWMFGVCMWEILMHGVKPFQGVKNNDVIGRIENGERLPMPPNCPPTLYSLMTKCWAYDPSRRPRFTEL
KAQLSTILEEEKAQQEERMRMESRRQATVSWDSGGSDEAPPKPSRPGYPSPRSSEGFYPSPQHMVQTNHYQVSGYPGSHGITAMAGSIYP
GQASLLDQTDSWNHRPQEIAMWQPNVEDSTVLDLRGIGQVLPTHLMEERLIRQQQEMEEDQRWLEKEERFLKPDVRLSRGSIDREDGSLQ
GPIGNQHIYQPVGKPDPAAPPKKPPRPGAPGHLGSLASLSSPADSYNEGVKLQPQEISPPPTANLDRSNDKVYENVTGLVKAVIEMSSKI
QPAPPEEYVPMVKEVGLALRTLLATVDETIPLLPASTHREIEMAQKLLNSDLGELINKMKLAQQYVMTSLQQEYKKQMLTAAHALAVDAK

--------------------------------------------------------------
>78627_78627_4_RUFY3-PTK2_RUFY3_chr4_71660611_ENST00000502653_PTK2_chr8_141889736_ENST00000535192_length(transcript)=5494nt_BP=1593nt
GATTATGTGTTCAGAAGGCAGTCTCAGTGAACTTCTCAAAGTGAGAAGGTTGTAGCTTTTAATACAGTCTCAGAAGCCTATGGGACAAAG
TTTTCTGGACACGGTTCATCCCTTCTTGTTGCTCTGCCCTGAAAATAACCTGGCTAGTCACCCTTTCAAGACTCTTGGGAGGATTTGACA
GATTTGGTGGAGCAAATGCGCGATGATACAGAAGATCCTAATTATCTCATGGCTAATGAACGCATGAACCTCATGAACATGGCCAAGCTG
AGTATCAAGGGCTTGATTGAATCAGCTCTGAACCTGGGGAGGACTCTTGACTCTGACTATGCACCTCTCCAGCAATTCTTTGTGGTGATG
GAGCACTGTCTGAAACATGGCTTGAAAGCTAAAAAAACTTTTCTCGGACAAAATAAATCCTTCTGGGGGCCTCTAGAACTGGTAGAAAAG
CTTGTTCCAGAAGCCGCAGAGATAACAGCAAGTGTTAAAGATCTTCCAGGACTTAAGACACCAGTAGGTAGAGGAAGAGCCTGGCTTCGT
TTGGCATTAATGCAAAAGAAACTTTCAGAATATATGAAAGCTTTGATCAATAAGAAAGAACTTCTCAGTGAATTCTACGAACCCAATGCC
CTCATGATGGAAGAAGAAGGAGCCATAATTGCTGGTCTGTTGGTGGGTCTGAATGTCATTGATGCCAATTTCTGTATGAAAGGAGAAGAC
TTGGACTCTCAGGTTGGAGTTATAGATTTTTCAATGTATCTCAAGGACGGGAACAGCAGTAAAGGTACTGAAGGAGACGGTCAGATTACT
GCAATTCTGGACCAGAAGAACTATGTAGAAGAACTGAACAGACATTTGAATGCTACTGTAAACAACCTTCAGGCAAAAGTAGATGCATTA
GAAAAATCCAACACTAAACTGACAGAGGAGCTTGCAGTTGCAAACAACAGGATCATTACCTTACAAGAAGAAATGGAACGAGTTAAAGAG
GAAAGTTCCTACATACTGGAATCCAATCGGAAGGGTCCCAAGCAAGACAGAACTGCAGAAGGGCAAGCACTAAGTGAAGCAAGAAAGCAT
TTAAAAGAAGAGACACAATTACGATTGGATGTTGAGAAAGAACTGGAGATGCAGATCAGCATGAGGCAGGAGATGGAATTGGCTATGAAG
ATGCTGGAGAAGGATGTCTGTGAGAAGCAGGATGCCCTGGTATCTCTTCGGCAGCAGCTGGATGACCTCAGAGCTCTCAAGCATGAACTT
GCCTTTAAGCTGCAGAGTTCAGACTTAGGAGTAAAACAGAAAAGTGAACTAAACAGTCGCTTGGAAGAGAAGACTAATCAGATGGCTGCT
ACCATTAAACAACTTGAACAAAGATTGCGCCAGGCTGAGCGAAGCCGCCAATCTGCTGAGTTGGACAACCGGCTCTTCAAACAGGACTTT
GGAGACAAGATCAACAGTCTGCAGCTGGAAGTCGAGGAGCTCACCAGGCAGCGGAACCAGCTTGAGTTAGAACTAAAACAGGAAAAAGAA
AGAAGATTACAAAACGACAGGAGCATCCCAGGAAGGGGTTCCCAGAAGTCAGAATCCAAGATGGGCATCATTCAGAAGATAGTGGACAGT
CACAAAGTAAAGCATGTGGCCTGCTATGGATTCCGCCTCAGTCACCTGCGGTCAGAGGAGGTTCACTGGCTTCACGTGGATATGGGCGTC
TCCAGTGTGAGGGAGAAGTATGAGCTTGCTCACCCACCAGAGGAGTGGAAATATGAATTGAGAATTCGTTATTTGCCAAAAGGATTTCTA
AACCAGTTTACTGAAGATAAGCCAACTTTGAATTTCTTCTATCAACAGGTGAAGAGCGATTATATGTTAGAGATAGCTGATCAAGTGGAC
CAGGAAATTGCTTTGAAGTTGGGTTGTCTAGAAATACGGCGATCATACTGGGAGATGCGGGGCAATGCACTAGAAAAGAAGTCTAACTAT
GAAGTATTAGAAAAAGATGTTGGTTTAAAGCGATTTTTTCCTAAGAGTTTACTGGATTCTGTCAAGGCCAAAACACTAAGAAAACTGATC
CAACAAACATTTAGACAATTTGCCAACCTTAATAGAGAAGAAAGTATTCTGAAATTCTTTGAGATCCTGTCTCCAGTCTACAGATTTGAT
AAGGAATGCTTCAAGTGTGCTCTTGGTTCAAGCTGGATTATTTCAGTGGAACTGGCAATCGGCCCAGAAGAAGGAATCAGTTACCTAACG
GACAAGGGCTGCAATCCCACACATCTTGCTGACTTCACTCAAGTGCAAACCATTCAGTATTCAAACAGTGAAGACAAGGACAGAAAAGGA
ATGCTACAACTAAAAATAGCAGGTGCACCCGAGCCTCTGACAGTGACGGCACCATCCCTAACCATTGCGGAGAATATGGCTGACCTAATA
GATGGGTACTGCCGGCTGGTGAATGGAACCTCGCAGTCATTTATCATCAGACCTCAGAAAGAAGGTGAACGGGCTTTGCCATCAATACCA
AAGTTGGCCAACAGCGAAAAGCAAGGCATGCGGACACACGCCGTCTCTGTGTCAGAAACAGATGATTATGCTGAGATTATAGATGAAGAA
GATACTTACACCATGCCCTCAACCAGGGATTATGAGATTCAAAGAGAAAGAATAGAACTTGGACGATGTATTGGAGAAGGCCAATTTGGA
GATGTACATCAAGGCATTTATATGAGTCCAGAGAATCCAGCTTTGGCGGTTGCAATTAAAACATGTAAAAACTGTACTTCGGACAGCGTG
AGAGAGAAATTTCTTCAAGAAGCCTTAACAATGCGTCAGTTTGACCATCCTCATATTGTGAAGCTGATTGGAGTCATCACAGAGAATCCT
GTCTGGATAATCATGGAGCTGTGCACACTTGGAGAGCTGAGGTCATTTTTGCAAGTAAGGAAATACAGTTTGGATCTAGCATCTTTGATC
CTGTATGCCTATCAGCTTAGTACAGCTCTTGCATATCTAGAGAGCAAAAGATTTGTACACAGGGACATTGCTGCTCGGAATGTTCTGGTG
TCCTCAAATGATTGTGTAAAATTAGGAGACTTTGGATTATCCCGATATATGGAAGATAGTACTTACTACAAAGCTTCCAAAGGAAAATTG
CCTATTAAATGGATGGCTCCAGAGTCAATCAATTTTCGACGTTTTACCTCAGCTAGTGACGTATGGATGTTTGGTGTGTGTATGTGGGAG
ATACTGATGCATGGTGTGAAGCCTTTTCAAGGAGTGAAGAACAATGATGTAATCGGTCGAATTGAAAATGGGGAAAGATTACCAATGCCT
CCAAATTGTCCTCCTACCCTCTACAGCCTTATGACGAAATGCTGGGCCTATGACCCCAGCAGGCGGCCCAGGTTTACTGAACTTAAAGCT
CAGCTCAGCACAATCCTGGAGGAAGAGAAGGCTCAGCAAGAAGAGCGCATGAGGATGGAGTCCAGAAGACAGGCCACAGTGTCCTGGGAC
TCCGGAGGGTCTGATGAAGCACCGCCCAAGCCCAGCAGACCGGGTTATCCCAGTCCGAGGTCCAGCGAAGGATTTTATCCCAGCCCACAG
CACATGGTACAAACCAATCATTACCAGGACTCTACAGTATTGGACCTGCGAGGGATTGGGCAAGTGTTGCCAACCCATCTGATGGAAGAG
CGTCTAATCCGACAGCAACAGGAAATGGAAGAAGATCAGCGCTGGCTGGAAAAAGAGGAAAGATTTCTGAAACCTGATGTGAGACTCTCT
CGAGGCAGTATTGACAGGGAGGATGGAAGTCTTCAGGGTCCGATTGGAAACCAACATATATATCAGCCTGTGGGTAAACCAGATCCTGCA
GCTCCACCAAAGAAACCGCCTCGCCCTGGAGCTCCCGGTCATCTGGGAAGCCTTGCCAGCCTCAGCAGCCCTGCTGACAGCTACAACGAG
GGTGTCAAGCTTCAGCCCCAGGAAATCAGCCCCCCTCCTACTGCCAACCTGGACCGGTCGAATGATAAGGTGTACGAGAATGTGACGGGC
CTGGTGAAAGCTGTCATCGAGATGTCCAGTAAAATCCAGCCAGCCCCACCAGAGGAGTATGTCCCTATGGTGAAGGAAGTCGGCTTGGCC
CTGAGGACATTATTGGCCACTGTGGATGAGACCATTCCCCTCCTACCAGCCAGCACCCACCGAGAGATTGAGATGGCACAGAAGCTATTG
AACTCTGACCTGGGTGAGCTCATCAACAAGATGAAACTGGCCCAGCAGTATGTCATGACCAGCCTCCAGCAAGAGTACAAAAAGCAAATG
CTGACTGCTGCTCACGCCCTGGCTGTGGATGCCAAAAACTTACTCGATGTCATTGACCAAGCAAGACTGAAAATGCTTGGGCAGACGAGA
CCACACTGAGCCTCCCCTAGGAGCACGTCTTGCTACCCTCTTTTGAAGATGTTCTCTAGCCTTCCACCAGCAGCGAGGAATTAACCCTGT
GTCCTCAGTCGCCAGCACTTACAGCTCCAACTTTTTTGAATGACCATCTGGTTGAAAAATCTTTCTCATATAAGTTTAACCACACTTTGA
TTTGGGTTCATTTTTTGTTTTGTTTTTTTCAATCATGATATTCAGAAAAATCCAGGATCCAAAATGTGGCGTTTTTCTAAGAATGAAAAT
TATATGTAAGCTTTTAAGCATCATGAAGAACAATTTATGTTCACATTAAGATACGTTCTAAAGGGGGATGGCCAAGGGGTGACATCTTAA
TTCCTAAACTACCTTAGCTGCATAGTGGAAGAGGAGAGCATGAAGCAAAGAATTCCAGGAAACCCAAGAGGCTGAGAATTCTTTTGTCTA
CCATAGAATTATTATCCAGACTGGAATTTTTGTTTGTTAGAACACCCTTCAGTTGCAATATGCTAATCCCACTTTACAAAGAATATAAAA
GCTATATTTTGAAGACTTGAGTTATTTCAGAAAAAACTACAGCCCTTTTTGTCTTACCTGCCTTTTACTTTCGTGTGGATATGTGAAGCA
TTGGGTCGGGAACTAGCTGTAGAACACAACTAAAAACTCATGTCTTTTTTCACAGAATAATGTGCCAGTTTTTTGTAGCAATGTTATTTC
TCTTGGAAGCAGAAATGCTTTGTACCAGAGCACCTCCAAACTGCATTGAGGAGAAGTTCCAGAACCATCCCCTTTTTCCATTTTTATATA
ATTTATAAAGAAAGATTAAAGCCATGTTGACTATTTTACAGCCACTGGAGTTAACTAACCCTTCCTTGTATCTGTCTTCCCAGGAGAGAA
TGAAGCAAAACAGGAATTTGGTTTTCTTTTGATGTCCAGTTACACCATCCATTCTGTTAATTTTGAAAAAATATACCCTCCCTTTAGTTT
GTTGGGGGATATAAATTATTCTCAGGAAGAATATAATGAACTGTACAGTTACTTTGACCTATTAAAAAGGTGTTACCAGTAAAGTTCTTG

>78627_78627_4_RUFY3-PTK2_RUFY3_chr4_71660611_ENST00000502653_PTK2_chr8_141889736_ENST00000535192_length(amino acids)=1414AA_BP=473
MTDLVEQMRDDTEDPNYLMANERMNLMNMAKLSIKGLIESALNLGRTLDSDYAPLQQFFVVMEHCLKHGLKAKKTFLGQNKSFWGPLELV
EKLVPEAAEITASVKDLPGLKTPVGRGRAWLRLALMQKKLSEYMKALINKKELLSEFYEPNALMMEEEGAIIAGLLVGLNVIDANFCMKG
EDLDSQVGVIDFSMYLKDGNSSKGTEGDGQITAILDQKNYVEELNRHLNATVNNLQAKVDALEKSNTKLTEELAVANNRIITLQEEMERV
KEESSYILESNRKGPKQDRTAEGQALSEARKHLKEETQLRLDVEKELEMQISMRQEMELAMKMLEKDVCEKQDALVSLRQQLDDLRALKH
ELAFKLQSSDLGVKQKSELNSRLEEKTNQMAATIKQLEQRLRQAERSRQSAELDNRLFKQDFGDKINSLQLEVEELTRQRNQLELELKQE
KERRLQNDRSIPGRGSQKSESKMGIIQKIVDSHKVKHVACYGFRLSHLRSEEVHWLHVDMGVSSVREKYELAHPPEEWKYELRIRYLPKG
FLNQFTEDKPTLNFFYQQVKSDYMLEIADQVDQEIALKLGCLEIRRSYWEMRGNALEKKSNYEVLEKDVGLKRFFPKSLLDSVKAKTLRK
LIQQTFRQFANLNREESILKFFEILSPVYRFDKECFKCALGSSWIISVELAIGPEEGISYLTDKGCNPTHLADFTQVQTIQYSNSEDKDR
KGMLQLKIAGAPEPLTVTAPSLTIAENMADLIDGYCRLVNGTSQSFIIRPQKEGERALPSIPKLANSEKQGMRTHAVSVSETDDYAEIID
EEDTYTMPSTRDYEIQRERIELGRCIGEGQFGDVHQGIYMSPENPALAVAIKTCKNCTSDSVREKFLQEALTMRQFDHPHIVKLIGVITE
NPVWIIMELCTLGELRSFLQVRKYSLDLASLILYAYQLSTALAYLESKRFVHRDIAARNVLVSSNDCVKLGDFGLSRYMEDSTYYKASKG
KLPIKWMAPESINFRRFTSASDVWMFGVCMWEILMHGVKPFQGVKNNDVIGRIENGERLPMPPNCPPTLYSLMTKCWAYDPSRRPRFTEL
KAQLSTILEEEKAQQEERMRMESRRQATVSWDSGGSDEAPPKPSRPGYPSPRSSEGFYPSPQHMVQTNHYQDSTVLDLRGIGQVLPTHLM
EERLIRQQQEMEEDQRWLEKEERFLKPDVRLSRGSIDREDGSLQGPIGNQHIYQPVGKPDPAAPPKKPPRPGAPGHLGSLASLSSPADSY
NEGVKLQPQEISPPPTANLDRSNDKVYENVTGLVKAVIEMSSKIQPAPPEEYVPMVKEVGLALRTLLATVDETIPLLPASTHREIEMAQK

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Fusion Gene PPI Analysis for RUFY3-PTK2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
TgenePTK2chr4:71660611chr8:141889736ENST00000340930233912_105265.01066.0ARHGEF28
TgenePTK2chr4:71660611chr8:141889736ENST00000521059232912_105265.01053.0ARHGEF28
TgenePTK2chr4:71660611chr8:141889736ENST00000522684232912_105265.01053.0ARHGEF28


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for RUFY3-PTK2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for RUFY3-PTK2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource