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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:RUNX1-CBFA2T2 (FusionGDB2 ID:78645)

Fusion Gene Summary for RUNX1-CBFA2T2

check button Fusion gene summary
Fusion gene informationFusion gene name: RUNX1-CBFA2T2
Fusion gene ID: 78645
HgeneTgene
Gene symbol

RUNX1

CBFA2T2

Gene ID

861

9139

Gene nameRUNX family transcription factor 1CBFA2/RUNX1 partner transcriptional co-repressor 2
SynonymsAML1|AML1-EVI-1|AMLCR1|CBF2alpha|CBFA2|EVI-1|PEBP2aB|PEBP2alphaEHT|MTGR1|ZMYND3|p85
Cytomap

21q22.12

20q11.21-q11.22

Type of geneprotein-codingprotein-coding
Descriptionrunt-related transcription factor 1AML1-EVI-1 fusion proteinPEA2-alpha BPEBP2-alpha BSL3-3 enhancer factor 1 alpha B subunitSL3/AKV core-binding factor alpha B subunitacute myeloid leukemia 1 proteincore-binding factor, runt domain, alpha subunit 2protein CBFA2T2CBFA2/RUNX1 translocation partner 2ETO homolog on chromosome 20ETO homologous on chromosome 20MTG8-like proteinMTG8-related protein 1core-binding factor, runt domain, alpha subunit 2; translocated to, 2myeloid translocation gene-rela
Modification date2020032220200313
UniProtAcc.

O43439

Ensembl transtripts involved in fusion geneENST00000300305, ENST00000325074, 
ENST00000344691, ENST00000358356, 
ENST00000399240, ENST00000437180, 
ENST00000486278, ENST00000494829, 
ENST00000344201, ENST00000346541, 
ENST00000359606, ENST00000397798, 
ENST00000397800, ENST00000492345, 
ENST00000491618, ENST00000543126, 
ENST00000342704, ENST00000375279, 
Fusion gene scores* DoF score46 X 68 X 13=4066417 X 18 X 9=2754
# samples 8925
** MAII scorelog2(89/40664*10)=-5.51380298959468
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(25/2754*10)=-3.46152855947288
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: RUNX1 [Title/Abstract] AND CBFA2T2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointRUNX1(36231874)-CBFA2T2(32194762), # samples:1
RUNX1(36231771)-CBFA2T2(32194762), # samples:1
RUNX1(36095625)-CBFA2T2(32161779), # samples:1
Anticipated loss of major functional domain due to fusion event.RUNX1-CBFA2T2 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
RUNX1-CBFA2T2 seems lost the major protein functional domain in Hgene partner, which is a transcription factor due to the frame-shifted ORF.
RUNX1-CBFA2T2 seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF.
RUNX1-CBFA2T2 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneRUNX1

GO:0030097

hemopoiesis

21873977

HgeneRUNX1

GO:0045893

positive regulation of transcription, DNA-templated

10207087|14970218

HgeneRUNX1

GO:0045944

positive regulation of transcription by RNA polymerase II

9199349|10207087|14970218|21873977

TgeneCBFA2T2

GO:0010976

positive regulation of neuron projection development

19026687

TgeneCBFA2T2

GO:0045892

negative regulation of transcription, DNA-templated

23251453


check buttonFusion gene breakpoints across RUNX1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across CBFA2T2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4acute myeloid leukemiaGU070940RUNX1chr21

36231874

CBFA2T2chr20

32194762
ChiTaRS5.0N/AGU070940RUNX1chr21

36231771

-CBFA2T2chr20

32194762

+
ChiTaRS5.0N/AGU086368RUNX1chr21

36095625

-CBFA2T2chr20

32161779

+


Top

Fusion Gene ORF analysis for RUNX1-CBFA2T2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000300305ENST00000344201RUNX1chr21

36231771

-CBFA2T2chr20

32194762

+
5CDS-5UTRENST00000300305ENST00000346541RUNX1chr21

36231771

-CBFA2T2chr20

32194762

+
5CDS-5UTRENST00000300305ENST00000359606RUNX1chr21

36231771

-CBFA2T2chr20

32194762

+
5CDS-5UTRENST00000300305ENST00000397798RUNX1chr21

36231771

-CBFA2T2chr20

32194762

+
5CDS-5UTRENST00000300305ENST00000397800RUNX1chr21

36231771

-CBFA2T2chr20

32194762

+
5CDS-5UTRENST00000300305ENST00000492345RUNX1chr21

36231771

-CBFA2T2chr20

32194762

+
5CDS-5UTRENST00000325074ENST00000344201RUNX1chr21

36231771

-CBFA2T2chr20

32194762

+
5CDS-5UTRENST00000325074ENST00000346541RUNX1chr21

36231771

-CBFA2T2chr20

32194762

+
5CDS-5UTRENST00000325074ENST00000359606RUNX1chr21

36231771

-CBFA2T2chr20

32194762

+
5CDS-5UTRENST00000325074ENST00000397798RUNX1chr21

36231771

-CBFA2T2chr20

32194762

+
5CDS-5UTRENST00000325074ENST00000397800RUNX1chr21

36231771

-CBFA2T2chr20

32194762

+
5CDS-5UTRENST00000325074ENST00000492345RUNX1chr21

36231771

-CBFA2T2chr20

32194762

+
5CDS-5UTRENST00000344691ENST00000344201RUNX1chr21

36231771

-CBFA2T2chr20

32194762

+
5CDS-5UTRENST00000344691ENST00000346541RUNX1chr21

36231771

-CBFA2T2chr20

32194762

+
5CDS-5UTRENST00000344691ENST00000359606RUNX1chr21

36231771

-CBFA2T2chr20

32194762

+
5CDS-5UTRENST00000344691ENST00000397798RUNX1chr21

36231771

-CBFA2T2chr20

32194762

+
5CDS-5UTRENST00000344691ENST00000397800RUNX1chr21

36231771

-CBFA2T2chr20

32194762

+
5CDS-5UTRENST00000344691ENST00000492345RUNX1chr21

36231771

-CBFA2T2chr20

32194762

+
5CDS-5UTRENST00000358356ENST00000344201RUNX1chr21

36231771

-CBFA2T2chr20

32194762

+
5CDS-5UTRENST00000358356ENST00000346541RUNX1chr21

36231771

-CBFA2T2chr20

32194762

+
5CDS-5UTRENST00000358356ENST00000359606RUNX1chr21

36231771

-CBFA2T2chr20

32194762

+
5CDS-5UTRENST00000358356ENST00000397798RUNX1chr21

36231771

-CBFA2T2chr20

32194762

+
5CDS-5UTRENST00000358356ENST00000397800RUNX1chr21

36231771

-CBFA2T2chr20

32194762

+
5CDS-5UTRENST00000358356ENST00000492345RUNX1chr21

36231771

-CBFA2T2chr20

32194762

+
5CDS-5UTRENST00000399240ENST00000344201RUNX1chr21

36231771

-CBFA2T2chr20

32194762

+
5CDS-5UTRENST00000399240ENST00000346541RUNX1chr21

36231771

-CBFA2T2chr20

32194762

+
5CDS-5UTRENST00000399240ENST00000359606RUNX1chr21

36231771

-CBFA2T2chr20

32194762

+
5CDS-5UTRENST00000399240ENST00000397798RUNX1chr21

36231771

-CBFA2T2chr20

32194762

+
5CDS-5UTRENST00000399240ENST00000397800RUNX1chr21

36231771

-CBFA2T2chr20

32194762

+
5CDS-5UTRENST00000399240ENST00000492345RUNX1chr21

36231771

-CBFA2T2chr20

32194762

+
5CDS-5UTRENST00000437180ENST00000344201RUNX1chr21

36231771

-CBFA2T2chr20

32194762

+
5CDS-5UTRENST00000437180ENST00000346541RUNX1chr21

36231771

-CBFA2T2chr20

32194762

+
5CDS-5UTRENST00000437180ENST00000359606RUNX1chr21

36231771

-CBFA2T2chr20

32194762

+
5CDS-5UTRENST00000437180ENST00000397798RUNX1chr21

36231771

-CBFA2T2chr20

32194762

+
5CDS-5UTRENST00000437180ENST00000397800RUNX1chr21

36231771

-CBFA2T2chr20

32194762

+
5CDS-5UTRENST00000437180ENST00000492345RUNX1chr21

36231771

-CBFA2T2chr20

32194762

+
5CDS-5UTRENST00000486278ENST00000344201RUNX1chr21

36231771

-CBFA2T2chr20

32194762

+
5CDS-5UTRENST00000486278ENST00000346541RUNX1chr21

36231771

-CBFA2T2chr20

32194762

+
5CDS-5UTRENST00000486278ENST00000359606RUNX1chr21

36231771

-CBFA2T2chr20

32194762

+
5CDS-5UTRENST00000486278ENST00000397798RUNX1chr21

36231771

-CBFA2T2chr20

32194762

+
5CDS-5UTRENST00000486278ENST00000397800RUNX1chr21

36231771

-CBFA2T2chr20

32194762

+
5CDS-5UTRENST00000486278ENST00000492345RUNX1chr21

36231771

-CBFA2T2chr20

32194762

+
5CDS-intronENST00000300305ENST00000491618RUNX1chr21

36231771

-CBFA2T2chr20

32194762

+
5CDS-intronENST00000300305ENST00000543126RUNX1chr21

36231771

-CBFA2T2chr20

32194762

+
5CDS-intronENST00000325074ENST00000491618RUNX1chr21

36231771

-CBFA2T2chr20

32194762

+
5CDS-intronENST00000325074ENST00000543126RUNX1chr21

36231771

-CBFA2T2chr20

32194762

+
5CDS-intronENST00000344691ENST00000491618RUNX1chr21

36231771

-CBFA2T2chr20

32194762

+
5CDS-intronENST00000344691ENST00000543126RUNX1chr21

36231771

-CBFA2T2chr20

32194762

+
5CDS-intronENST00000358356ENST00000491618RUNX1chr21

36231771

-CBFA2T2chr20

32194762

+
5CDS-intronENST00000358356ENST00000543126RUNX1chr21

36231771

-CBFA2T2chr20

32194762

+
5CDS-intronENST00000399240ENST00000491618RUNX1chr21

36231771

-CBFA2T2chr20

32194762

+
5CDS-intronENST00000399240ENST00000543126RUNX1chr21

36231771

-CBFA2T2chr20

32194762

+
5CDS-intronENST00000437180ENST00000491618RUNX1chr21

36231771

-CBFA2T2chr20

32194762

+
5CDS-intronENST00000437180ENST00000543126RUNX1chr21

36231771

-CBFA2T2chr20

32194762

+
5CDS-intronENST00000486278ENST00000491618RUNX1chr21

36231771

-CBFA2T2chr20

32194762

+
5CDS-intronENST00000486278ENST00000543126RUNX1chr21

36231771

-CBFA2T2chr20

32194762

+
Frame-shiftENST00000437180ENST00000342704RUNX1chr21

36231771

-CBFA2T2chr20

32194762

+
Frame-shiftENST00000437180ENST00000375279RUNX1chr21

36231771

-CBFA2T2chr20

32194762

+
In-frameENST00000300305ENST00000342704RUNX1chr21

36231771

-CBFA2T2chr20

32194762

+
In-frameENST00000300305ENST00000375279RUNX1chr21

36231771

-CBFA2T2chr20

32194762

+
In-frameENST00000325074ENST00000342704RUNX1chr21

36231771

-CBFA2T2chr20

32194762

+
In-frameENST00000325074ENST00000375279RUNX1chr21

36231771

-CBFA2T2chr20

32194762

+
In-frameENST00000344691ENST00000342704RUNX1chr21

36231771

-CBFA2T2chr20

32194762

+
In-frameENST00000344691ENST00000375279RUNX1chr21

36231771

-CBFA2T2chr20

32194762

+
In-frameENST00000358356ENST00000342704RUNX1chr21

36231771

-CBFA2T2chr20

32194762

+
In-frameENST00000358356ENST00000375279RUNX1chr21

36231771

-CBFA2T2chr20

32194762

+
In-frameENST00000399240ENST00000342704RUNX1chr21

36231771

-CBFA2T2chr20

32194762

+
In-frameENST00000399240ENST00000375279RUNX1chr21

36231771

-CBFA2T2chr20

32194762

+
In-frameENST00000486278ENST00000342704RUNX1chr21

36231771

-CBFA2T2chr20

32194762

+
In-frameENST00000486278ENST00000375279RUNX1chr21

36231771

-CBFA2T2chr20

32194762

+
intron-3CDSENST00000300305ENST00000342704RUNX1chr21

36231874

CBFA2T2chr20

32194762

intron-3CDSENST00000300305ENST00000375279RUNX1chr21

36231874

CBFA2T2chr20

32194762

intron-3CDSENST00000325074ENST00000342704RUNX1chr21

36231874

CBFA2T2chr20

32194762

intron-3CDSENST00000325074ENST00000375279RUNX1chr21

36231874

CBFA2T2chr20

32194762

intron-3CDSENST00000344691ENST00000342704RUNX1chr21

36231874

CBFA2T2chr20

32194762

intron-3CDSENST00000344691ENST00000375279RUNX1chr21

36231874

CBFA2T2chr20

32194762

intron-3CDSENST00000358356ENST00000342704RUNX1chr21

36231874

CBFA2T2chr20

32194762

intron-3CDSENST00000358356ENST00000375279RUNX1chr21

36231874

CBFA2T2chr20

32194762

intron-3CDSENST00000399240ENST00000342704RUNX1chr21

36231874

CBFA2T2chr20

32194762

intron-3CDSENST00000399240ENST00000375279RUNX1chr21

36231874

CBFA2T2chr20

32194762

intron-3CDSENST00000437180ENST00000342704RUNX1chr21

36231874

CBFA2T2chr20

32194762

intron-3CDSENST00000437180ENST00000375279RUNX1chr21

36231874

CBFA2T2chr20

32194762

intron-3CDSENST00000486278ENST00000342704RUNX1chr21

36231874

CBFA2T2chr20

32194762

intron-3CDSENST00000486278ENST00000375279RUNX1chr21

36231874

CBFA2T2chr20

32194762

intron-3CDSENST00000494829ENST00000342704RUNX1chr21

36231874

CBFA2T2chr20

32194762

intron-3CDSENST00000494829ENST00000342704RUNX1chr21

36231771

-CBFA2T2chr20

32194762

+
intron-3CDSENST00000494829ENST00000375279RUNX1chr21

36231874

CBFA2T2chr20

32194762

intron-3CDSENST00000494829ENST00000375279RUNX1chr21

36231771

-CBFA2T2chr20

32194762

+
intron-5UTRENST00000300305ENST00000344201RUNX1chr21

36231874

CBFA2T2chr20

32194762

intron-5UTRENST00000300305ENST00000346541RUNX1chr21

36231874

CBFA2T2chr20

32194762

intron-5UTRENST00000300305ENST00000346541RUNX1chr21

36095625

-CBFA2T2chr20

32161779

+
intron-5UTRENST00000300305ENST00000359606RUNX1chr21

36231874

CBFA2T2chr20

32194762

intron-5UTRENST00000300305ENST00000375279RUNX1chr21

36095625

-CBFA2T2chr20

32161779

+
intron-5UTRENST00000300305ENST00000397798RUNX1chr21

36231874

CBFA2T2chr20

32194762

intron-5UTRENST00000300305ENST00000397798RUNX1chr21

36095625

-CBFA2T2chr20

32161779

+
intron-5UTRENST00000300305ENST00000397800RUNX1chr21

36231874

CBFA2T2chr20

32194762

intron-5UTRENST00000300305ENST00000492345RUNX1chr21

36231874

CBFA2T2chr20

32194762

intron-5UTRENST00000300305ENST00000492345RUNX1chr21

36095625

-CBFA2T2chr20

32161779

+
intron-5UTRENST00000325074ENST00000344201RUNX1chr21

36231874

CBFA2T2chr20

32194762

intron-5UTRENST00000325074ENST00000346541RUNX1chr21

36231874

CBFA2T2chr20

32194762

intron-5UTRENST00000325074ENST00000346541RUNX1chr21

36095625

-CBFA2T2chr20

32161779

+
intron-5UTRENST00000325074ENST00000359606RUNX1chr21

36231874

CBFA2T2chr20

32194762

intron-5UTRENST00000325074ENST00000375279RUNX1chr21

36095625

-CBFA2T2chr20

32161779

+
intron-5UTRENST00000325074ENST00000397798RUNX1chr21

36231874

CBFA2T2chr20

32194762

intron-5UTRENST00000325074ENST00000397798RUNX1chr21

36095625

-CBFA2T2chr20

32161779

+
intron-5UTRENST00000325074ENST00000397800RUNX1chr21

36231874

CBFA2T2chr20

32194762

intron-5UTRENST00000325074ENST00000492345RUNX1chr21

36231874

CBFA2T2chr20

32194762

intron-5UTRENST00000325074ENST00000492345RUNX1chr21

36095625

-CBFA2T2chr20

32161779

+
intron-5UTRENST00000344691ENST00000344201RUNX1chr21

36231874

CBFA2T2chr20

32194762

intron-5UTRENST00000344691ENST00000346541RUNX1chr21

36231874

CBFA2T2chr20

32194762

intron-5UTRENST00000344691ENST00000346541RUNX1chr21

36095625

-CBFA2T2chr20

32161779

+
intron-5UTRENST00000344691ENST00000359606RUNX1chr21

36231874

CBFA2T2chr20

32194762

intron-5UTRENST00000344691ENST00000375279RUNX1chr21

36095625

-CBFA2T2chr20

32161779

+
intron-5UTRENST00000344691ENST00000397798RUNX1chr21

36231874

CBFA2T2chr20

32194762

intron-5UTRENST00000344691ENST00000397798RUNX1chr21

36095625

-CBFA2T2chr20

32161779

+
intron-5UTRENST00000344691ENST00000397800RUNX1chr21

36231874

CBFA2T2chr20

32194762

intron-5UTRENST00000344691ENST00000492345RUNX1chr21

36231874

CBFA2T2chr20

32194762

intron-5UTRENST00000344691ENST00000492345RUNX1chr21

36095625

-CBFA2T2chr20

32161779

+
intron-5UTRENST00000358356ENST00000344201RUNX1chr21

36231874

CBFA2T2chr20

32194762

intron-5UTRENST00000358356ENST00000346541RUNX1chr21

36231874

CBFA2T2chr20

32194762

intron-5UTRENST00000358356ENST00000346541RUNX1chr21

36095625

-CBFA2T2chr20

32161779

+
intron-5UTRENST00000358356ENST00000359606RUNX1chr21

36231874

CBFA2T2chr20

32194762

intron-5UTRENST00000358356ENST00000375279RUNX1chr21

36095625

-CBFA2T2chr20

32161779

+
intron-5UTRENST00000358356ENST00000397798RUNX1chr21

36231874

CBFA2T2chr20

32194762

intron-5UTRENST00000358356ENST00000397798RUNX1chr21

36095625

-CBFA2T2chr20

32161779

+
intron-5UTRENST00000358356ENST00000397800RUNX1chr21

36231874

CBFA2T2chr20

32194762

intron-5UTRENST00000358356ENST00000492345RUNX1chr21

36231874

CBFA2T2chr20

32194762

intron-5UTRENST00000358356ENST00000492345RUNX1chr21

36095625

-CBFA2T2chr20

32161779

+
intron-5UTRENST00000399240ENST00000344201RUNX1chr21

36231874

CBFA2T2chr20

32194762

intron-5UTRENST00000399240ENST00000346541RUNX1chr21

36231874

CBFA2T2chr20

32194762

intron-5UTRENST00000399240ENST00000346541RUNX1chr21

36095625

-CBFA2T2chr20

32161779

+
intron-5UTRENST00000399240ENST00000359606RUNX1chr21

36231874

CBFA2T2chr20

32194762

intron-5UTRENST00000399240ENST00000375279RUNX1chr21

36095625

-CBFA2T2chr20

32161779

+
intron-5UTRENST00000399240ENST00000397798RUNX1chr21

36231874

CBFA2T2chr20

32194762

intron-5UTRENST00000399240ENST00000397798RUNX1chr21

36095625

-CBFA2T2chr20

32161779

+
intron-5UTRENST00000399240ENST00000397800RUNX1chr21

36231874

CBFA2T2chr20

32194762

intron-5UTRENST00000399240ENST00000492345RUNX1chr21

36231874

CBFA2T2chr20

32194762

intron-5UTRENST00000399240ENST00000492345RUNX1chr21

36095625

-CBFA2T2chr20

32161779

+
intron-5UTRENST00000437180ENST00000344201RUNX1chr21

36231874

CBFA2T2chr20

32194762

intron-5UTRENST00000437180ENST00000346541RUNX1chr21

36231874

CBFA2T2chr20

32194762

intron-5UTRENST00000437180ENST00000346541RUNX1chr21

36095625

-CBFA2T2chr20

32161779

+
intron-5UTRENST00000437180ENST00000359606RUNX1chr21

36231874

CBFA2T2chr20

32194762

intron-5UTRENST00000437180ENST00000375279RUNX1chr21

36095625

-CBFA2T2chr20

32161779

+
intron-5UTRENST00000437180ENST00000397798RUNX1chr21

36231874

CBFA2T2chr20

32194762

intron-5UTRENST00000437180ENST00000397798RUNX1chr21

36095625

-CBFA2T2chr20

32161779

+
intron-5UTRENST00000437180ENST00000397800RUNX1chr21

36231874

CBFA2T2chr20

32194762

intron-5UTRENST00000437180ENST00000492345RUNX1chr21

36231874

CBFA2T2chr20

32194762

intron-5UTRENST00000437180ENST00000492345RUNX1chr21

36095625

-CBFA2T2chr20

32161779

+
intron-5UTRENST00000486278ENST00000344201RUNX1chr21

36231874

CBFA2T2chr20

32194762

intron-5UTRENST00000486278ENST00000346541RUNX1chr21

36231874

CBFA2T2chr20

32194762

intron-5UTRENST00000486278ENST00000346541RUNX1chr21

36095625

-CBFA2T2chr20

32161779

+
intron-5UTRENST00000486278ENST00000359606RUNX1chr21

36231874

CBFA2T2chr20

32194762

intron-5UTRENST00000486278ENST00000375279RUNX1chr21

36095625

-CBFA2T2chr20

32161779

+
intron-5UTRENST00000486278ENST00000397798RUNX1chr21

36231874

CBFA2T2chr20

32194762

intron-5UTRENST00000486278ENST00000397798RUNX1chr21

36095625

-CBFA2T2chr20

32161779

+
intron-5UTRENST00000486278ENST00000397800RUNX1chr21

36231874

CBFA2T2chr20

32194762

intron-5UTRENST00000486278ENST00000492345RUNX1chr21

36231874

CBFA2T2chr20

32194762

intron-5UTRENST00000486278ENST00000492345RUNX1chr21

36095625

-CBFA2T2chr20

32161779

+
intron-5UTRENST00000494829ENST00000344201RUNX1chr21

36231874

CBFA2T2chr20

32194762

intron-5UTRENST00000494829ENST00000344201RUNX1chr21

36231771

-CBFA2T2chr20

32194762

+
intron-5UTRENST00000494829ENST00000346541RUNX1chr21

36231874

CBFA2T2chr20

32194762

intron-5UTRENST00000494829ENST00000346541RUNX1chr21

36231771

-CBFA2T2chr20

32194762

+
intron-5UTRENST00000494829ENST00000346541RUNX1chr21

36095625

-CBFA2T2chr20

32161779

+
intron-5UTRENST00000494829ENST00000359606RUNX1chr21

36231874

CBFA2T2chr20

32194762

intron-5UTRENST00000494829ENST00000359606RUNX1chr21

36231771

-CBFA2T2chr20

32194762

+
intron-5UTRENST00000494829ENST00000375279RUNX1chr21

36095625

-CBFA2T2chr20

32161779

+
intron-5UTRENST00000494829ENST00000397798RUNX1chr21

36231874

CBFA2T2chr20

32194762

intron-5UTRENST00000494829ENST00000397798RUNX1chr21

36231771

-CBFA2T2chr20

32194762

+
intron-5UTRENST00000494829ENST00000397798RUNX1chr21

36095625

-CBFA2T2chr20

32161779

+
intron-5UTRENST00000494829ENST00000397800RUNX1chr21

36231874

CBFA2T2chr20

32194762

intron-5UTRENST00000494829ENST00000397800RUNX1chr21

36231771

-CBFA2T2chr20

32194762

+
intron-5UTRENST00000494829ENST00000492345RUNX1chr21

36231874

CBFA2T2chr20

32194762

intron-5UTRENST00000494829ENST00000492345RUNX1chr21

36231771

-CBFA2T2chr20

32194762

+
intron-5UTRENST00000494829ENST00000492345RUNX1chr21

36095625

-CBFA2T2chr20

32161779

+
intron-intronENST00000300305ENST00000342704RUNX1chr21

36095625

-CBFA2T2chr20

32161779

+
intron-intronENST00000300305ENST00000344201RUNX1chr21

36095625

-CBFA2T2chr20

32161779

+
intron-intronENST00000300305ENST00000359606RUNX1chr21

36095625

-CBFA2T2chr20

32161779

+
intron-intronENST00000300305ENST00000397800RUNX1chr21

36095625

-CBFA2T2chr20

32161779

+
intron-intronENST00000300305ENST00000491618RUNX1chr21

36231874

CBFA2T2chr20

32194762

intron-intronENST00000300305ENST00000491618RUNX1chr21

36095625

-CBFA2T2chr20

32161779

+
intron-intronENST00000300305ENST00000543126RUNX1chr21

36231874

CBFA2T2chr20

32194762

intron-intronENST00000300305ENST00000543126RUNX1chr21

36095625

-CBFA2T2chr20

32161779

+
intron-intronENST00000325074ENST00000342704RUNX1chr21

36095625

-CBFA2T2chr20

32161779

+
intron-intronENST00000325074ENST00000344201RUNX1chr21

36095625

-CBFA2T2chr20

32161779

+
intron-intronENST00000325074ENST00000359606RUNX1chr21

36095625

-CBFA2T2chr20

32161779

+
intron-intronENST00000325074ENST00000397800RUNX1chr21

36095625

-CBFA2T2chr20

32161779

+
intron-intronENST00000325074ENST00000491618RUNX1chr21

36231874

CBFA2T2chr20

32194762

intron-intronENST00000325074ENST00000491618RUNX1chr21

36095625

-CBFA2T2chr20

32161779

+
intron-intronENST00000325074ENST00000543126RUNX1chr21

36231874

CBFA2T2chr20

32194762

intron-intronENST00000325074ENST00000543126RUNX1chr21

36095625

-CBFA2T2chr20

32161779

+
intron-intronENST00000344691ENST00000342704RUNX1chr21

36095625

-CBFA2T2chr20

32161779

+
intron-intronENST00000344691ENST00000344201RUNX1chr21

36095625

-CBFA2T2chr20

32161779

+
intron-intronENST00000344691ENST00000359606RUNX1chr21

36095625

-CBFA2T2chr20

32161779

+
intron-intronENST00000344691ENST00000397800RUNX1chr21

36095625

-CBFA2T2chr20

32161779

+
intron-intronENST00000344691ENST00000491618RUNX1chr21

36231874

CBFA2T2chr20

32194762

intron-intronENST00000344691ENST00000491618RUNX1chr21

36095625

-CBFA2T2chr20

32161779

+
intron-intronENST00000344691ENST00000543126RUNX1chr21

36231874

CBFA2T2chr20

32194762

intron-intronENST00000344691ENST00000543126RUNX1chr21

36095625

-CBFA2T2chr20

32161779

+
intron-intronENST00000358356ENST00000342704RUNX1chr21

36095625

-CBFA2T2chr20

32161779

+
intron-intronENST00000358356ENST00000344201RUNX1chr21

36095625

-CBFA2T2chr20

32161779

+
intron-intronENST00000358356ENST00000359606RUNX1chr21

36095625

-CBFA2T2chr20

32161779

+
intron-intronENST00000358356ENST00000397800RUNX1chr21

36095625

-CBFA2T2chr20

32161779

+
intron-intronENST00000358356ENST00000491618RUNX1chr21

36231874

CBFA2T2chr20

32194762

intron-intronENST00000358356ENST00000491618RUNX1chr21

36095625

-CBFA2T2chr20

32161779

+
intron-intronENST00000358356ENST00000543126RUNX1chr21

36231874

CBFA2T2chr20

32194762

intron-intronENST00000358356ENST00000543126RUNX1chr21

36095625

-CBFA2T2chr20

32161779

+
intron-intronENST00000399240ENST00000342704RUNX1chr21

36095625

-CBFA2T2chr20

32161779

+
intron-intronENST00000399240ENST00000344201RUNX1chr21

36095625

-CBFA2T2chr20

32161779

+
intron-intronENST00000399240ENST00000359606RUNX1chr21

36095625

-CBFA2T2chr20

32161779

+
intron-intronENST00000399240ENST00000397800RUNX1chr21

36095625

-CBFA2T2chr20

32161779

+
intron-intronENST00000399240ENST00000491618RUNX1chr21

36231874

CBFA2T2chr20

32194762

intron-intronENST00000399240ENST00000491618RUNX1chr21

36095625

-CBFA2T2chr20

32161779

+
intron-intronENST00000399240ENST00000543126RUNX1chr21

36231874

CBFA2T2chr20

32194762

intron-intronENST00000399240ENST00000543126RUNX1chr21

36095625

-CBFA2T2chr20

32161779

+
intron-intronENST00000437180ENST00000342704RUNX1chr21

36095625

-CBFA2T2chr20

32161779

+
intron-intronENST00000437180ENST00000344201RUNX1chr21

36095625

-CBFA2T2chr20

32161779

+
intron-intronENST00000437180ENST00000359606RUNX1chr21

36095625

-CBFA2T2chr20

32161779

+
intron-intronENST00000437180ENST00000397800RUNX1chr21

36095625

-CBFA2T2chr20

32161779

+
intron-intronENST00000437180ENST00000491618RUNX1chr21

36231874

CBFA2T2chr20

32194762

intron-intronENST00000437180ENST00000491618RUNX1chr21

36095625

-CBFA2T2chr20

32161779

+
intron-intronENST00000437180ENST00000543126RUNX1chr21

36231874

CBFA2T2chr20

32194762

intron-intronENST00000437180ENST00000543126RUNX1chr21

36095625

-CBFA2T2chr20

32161779

+
intron-intronENST00000486278ENST00000342704RUNX1chr21

36095625

-CBFA2T2chr20

32161779

+
intron-intronENST00000486278ENST00000344201RUNX1chr21

36095625

-CBFA2T2chr20

32161779

+
intron-intronENST00000486278ENST00000359606RUNX1chr21

36095625

-CBFA2T2chr20

32161779

+
intron-intronENST00000486278ENST00000397800RUNX1chr21

36095625

-CBFA2T2chr20

32161779

+
intron-intronENST00000486278ENST00000491618RUNX1chr21

36231874

CBFA2T2chr20

32194762

intron-intronENST00000486278ENST00000491618RUNX1chr21

36095625

-CBFA2T2chr20

32161779

+
intron-intronENST00000486278ENST00000543126RUNX1chr21

36231874

CBFA2T2chr20

32194762

intron-intronENST00000486278ENST00000543126RUNX1chr21

36095625

-CBFA2T2chr20

32161779

+
intron-intronENST00000494829ENST00000342704RUNX1chr21

36095625

-CBFA2T2chr20

32161779

+
intron-intronENST00000494829ENST00000344201RUNX1chr21

36095625

-CBFA2T2chr20

32161779

+
intron-intronENST00000494829ENST00000359606RUNX1chr21

36095625

-CBFA2T2chr20

32161779

+
intron-intronENST00000494829ENST00000397800RUNX1chr21

36095625

-CBFA2T2chr20

32161779

+
intron-intronENST00000494829ENST00000491618RUNX1chr21

36231874

CBFA2T2chr20

32194762

intron-intronENST00000494829ENST00000491618RUNX1chr21

36231771

-CBFA2T2chr20

32194762

+
intron-intronENST00000494829ENST00000491618RUNX1chr21

36095625

-CBFA2T2chr20

32161779

+
intron-intronENST00000494829ENST00000543126RUNX1chr21

36231874

CBFA2T2chr20

32194762

intron-intronENST00000494829ENST00000543126RUNX1chr21

36231771

-CBFA2T2chr20

32194762

+
intron-intronENST00000494829ENST00000543126RUNX1chr21

36095625

-CBFA2T2chr20

32161779

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000344691RUNX1chr2136231771-ENST00000342704CBFA2T2chr2032194762+4759211015783863761
ENST00000344691RUNX1chr2136231771-ENST00000375279CBFA2T2chr2032194762+9254211015783863761
ENST00000325074RUNX1chr2136231771-ENST00000342704CBFA2T2chr2032194762+322657702330776
ENST00000325074RUNX1chr2136231771-ENST00000375279CBFA2T2chr2032194762+772157702330776
ENST00000300305RUNX1chr2136231771-ENST00000342704CBFA2T2chr2032194762+370710584452811788
ENST00000300305RUNX1chr2136231771-ENST00000375279CBFA2T2chr2032194762+820210584452811788
ENST00000399240RUNX1chr2136231771-ENST00000342704CBFA2T2chr2032194762+3252603712356761
ENST00000399240RUNX1chr2136231771-ENST00000375279CBFA2T2chr2032194762+7747603712356761
ENST00000486278RUNX1chr2136231771-ENST00000342704CBFA2T2chr2032194762+34067571442510788
ENST00000486278RUNX1chr2136231771-ENST00000375279CBFA2T2chr2032194762+79017571442510788
ENST00000358356RUNX1chr2136231771-ENST00000342704CBFA2T2chr2032194762+4759211015783863761
ENST00000358356RUNX1chr2136231771-ENST00000375279CBFA2T2chr2032194762+9254211015783863761

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000344691ENST00000342704RUNX1chr2136231771-CBFA2T2chr2032194762+0.0259299780.97407
ENST00000344691ENST00000375279RUNX1chr2136231771-CBFA2T2chr2032194762+0.0105796090.9894204
ENST00000325074ENST00000342704RUNX1chr2136231771-CBFA2T2chr2032194762+0.0346208330.9653791
ENST00000325074ENST00000375279RUNX1chr2136231771-CBFA2T2chr2032194762+0.0101531350.9898469
ENST00000300305ENST00000342704RUNX1chr2136231771-CBFA2T2chr2032194762+0.0305812250.9694188
ENST00000300305ENST00000375279RUNX1chr2136231771-CBFA2T2chr2032194762+0.0094578690.9905421
ENST00000399240ENST00000342704RUNX1chr2136231771-CBFA2T2chr2032194762+0.031948370.9680517
ENST00000399240ENST00000375279RUNX1chr2136231771-CBFA2T2chr2032194762+0.0123885220.9876115
ENST00000486278ENST00000342704RUNX1chr2136231771-CBFA2T2chr2032194762+0.032791860.96720815
ENST00000486278ENST00000375279RUNX1chr2136231771-CBFA2T2chr2032194762+0.0101443550.98985565
ENST00000358356ENST00000342704RUNX1chr2136231771-CBFA2T2chr2032194762+0.0259299780.97407
ENST00000358356ENST00000375279RUNX1chr2136231771-CBFA2T2chr2032194762+0.0105796090.9894204

Top

Fusion Genomic Features for RUNX1-CBFA2T2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
RUNX1chr2136231770-CBFA2T2chr2032194761+0.000769550.9992305
RUNX1chr2136231770-CBFA2T2chr2032194761+0.000769550.9992305

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

Top

Fusion Protein Features for RUNX1-CBFA2T2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr21:36231874/chr20:32194762)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.CBFA2T2

O43439

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional corepressor which facilitates transcriptional repression via its association with DNA-binding transcription factors and recruitment of other corepressors and histone-modifying enzymes (PubMed:12559562, PubMed:15203199). Via association with PRDM14 is involved in regulation of embryonic stem cell (ESC) pluripotency (PubMed:27281218). Involved in primordial germ cell (PCG) formation. Stabilizes PRDM14 and OCT4 on chromatin in a homooligomerization-dependent manner (By similarity). Can repress the expression of MMP7 in a ZBTB33-dependent manner (PubMed:23251453). May function as a complex with the chimeric protein RUNX1/AML1-CBFA2T1/MTG8 (AML1-MTG8/ETO fusion protein) which is produced in acute myeloid leukemia with the chromosomal translocation t(8;21). May thus be involved in the repression of AML1-dependent transcription and the induction of G-CSF/CSF3-dependent cell growth. May be a tumor suppressor gene candidate involved in myeloid tumors with the deletion of the 20q11 region. Through heteromerization with CBFA2T3/MTG16 may be involved in regulation of the proliferation and the differentiation of erythroid progenitors by repressing the expression of TAL1 target genes (By similarity). Required for the maintenance of the secretory cell lineage in the small intestine. Can inhibit Notch signaling probably by association with RBPJ and may be involved in GFI1-mediated Paneth cell differentiation (By similarity). {ECO:0000250|UniProtKB:O70374, ECO:0000269|PubMed:23251453, ECO:0000303|PubMed:12559562, ECO:0000303|PubMed:15203199}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneRUNX1chr21:36231771chr20:32194762ENST00000300305-5850_178204481.0DomainRunt
HgeneRUNX1chr21:36231771chr20:32194762ENST00000325074-4750_178192469.0DomainRunt
HgeneRUNX1chr21:36231771chr20:32194762ENST00000344691-3650_178177454.0DomainRunt
HgeneRUNX1chr21:36231771chr20:32194762ENST00000358356-3550_178177251.0DomainRunt
HgeneRUNX1chr21:36231771chr20:32194762ENST00000437180-6950_178204481.0DomainRunt
TgeneCBFA2T2chr21:36231771chr20:32194762ENST00000342704011451_49111596.0Coiled coilOntology_term=ECO:0000255
TgeneCBFA2T2chr21:36231771chr20:32194762ENST0000034420106451_4910264.0Coiled coilOntology_term=ECO:0000255
TgeneCBFA2T2chr21:36231771chr20:32194762ENST00000346541112451_49120605.0Coiled coilOntology_term=ECO:0000255
TgeneCBFA2T2chr21:36231771chr20:32194762ENST00000359606011451_49130615.0Coiled coilOntology_term=ECO:0000255
TgeneCBFA2T2chr21:36231771chr20:32194762ENST00000375279112451_49120605.0Coiled coilOntology_term=ECO:0000255
TgeneCBFA2T2chr21:36231771chr20:32194762ENST0000039779817451_4910264.0Coiled coilOntology_term=ECO:0000255
TgeneCBFA2T2chr21:36231771chr20:32194762ENST00000397800011451_4910576.0Coiled coilOntology_term=ECO:0000255
TgeneCBFA2T2chr21:36231771chr20:32194762ENST00000492345213451_4910576.0Coiled coilOntology_term=ECO:0000255
TgeneCBFA2T2chr21:36231771chr20:32194762ENST0000034270401133_9711596.0Compositional biasNote=Pro-rich
TgeneCBFA2T2chr21:36231771chr20:32194762ENST000003442010633_970264.0Compositional biasNote=Pro-rich
TgeneCBFA2T2chr21:36231771chr20:32194762ENST0000034654111233_9720605.0Compositional biasNote=Pro-rich
TgeneCBFA2T2chr21:36231771chr20:32194762ENST0000035960601133_9730615.0Compositional biasNote=Pro-rich
TgeneCBFA2T2chr21:36231771chr20:32194762ENST0000037527911233_9720605.0Compositional biasNote=Pro-rich
TgeneCBFA2T2chr21:36231771chr20:32194762ENST000003977981733_970264.0Compositional biasNote=Pro-rich
TgeneCBFA2T2chr21:36231771chr20:32194762ENST0000039780001133_970576.0Compositional biasNote=Pro-rich
TgeneCBFA2T2chr21:36231771chr20:32194762ENST0000049234521333_970576.0Compositional biasNote=Pro-rich
TgeneCBFA2T2chr21:36231771chr20:32194762ENST00000342704011113_20811596.0DomainTAFH
TgeneCBFA2T2chr21:36231771chr20:32194762ENST0000034420106113_2080264.0DomainTAFH
TgeneCBFA2T2chr21:36231771chr20:32194762ENST00000346541112113_20820605.0DomainTAFH
TgeneCBFA2T2chr21:36231771chr20:32194762ENST00000359606011113_20830615.0DomainTAFH
TgeneCBFA2T2chr21:36231771chr20:32194762ENST00000375279112113_20820605.0DomainTAFH
TgeneCBFA2T2chr21:36231771chr20:32194762ENST0000039779817113_2080264.0DomainTAFH
TgeneCBFA2T2chr21:36231771chr20:32194762ENST00000397800011113_2080576.0DomainTAFH
TgeneCBFA2T2chr21:36231771chr20:32194762ENST00000492345213113_2080576.0DomainTAFH
TgeneCBFA2T2chr21:36231771chr20:32194762ENST00000342704011331_37711596.0RegionNervy homology region 2 (NHR2)
TgeneCBFA2T2chr21:36231771chr20:32194762ENST00000342704011435_48411596.0RegionNervy homology region 3 (NHR3)
TgeneCBFA2T2chr21:36231771chr20:32194762ENST0000034420106331_3770264.0RegionNervy homology region 2 (NHR2)
TgeneCBFA2T2chr21:36231771chr20:32194762ENST0000034420106435_4840264.0RegionNervy homology region 3 (NHR3)
TgeneCBFA2T2chr21:36231771chr20:32194762ENST00000346541112331_37720605.0RegionNervy homology region 2 (NHR2)
TgeneCBFA2T2chr21:36231771chr20:32194762ENST00000346541112435_48420605.0RegionNervy homology region 3 (NHR3)
TgeneCBFA2T2chr21:36231771chr20:32194762ENST00000359606011331_37730615.0RegionNervy homology region 2 (NHR2)
TgeneCBFA2T2chr21:36231771chr20:32194762ENST00000359606011435_48430615.0RegionNervy homology region 3 (NHR3)
TgeneCBFA2T2chr21:36231771chr20:32194762ENST00000375279112331_37720605.0RegionNervy homology region 2 (NHR2)
TgeneCBFA2T2chr21:36231771chr20:32194762ENST00000375279112435_48420605.0RegionNervy homology region 3 (NHR3)
TgeneCBFA2T2chr21:36231771chr20:32194762ENST0000039779817331_3770264.0RegionNervy homology region 2 (NHR2)
TgeneCBFA2T2chr21:36231771chr20:32194762ENST0000039779817435_4840264.0RegionNervy homology region 3 (NHR3)
TgeneCBFA2T2chr21:36231771chr20:32194762ENST00000397800011331_3770576.0RegionNervy homology region 2 (NHR2)
TgeneCBFA2T2chr21:36231771chr20:32194762ENST00000397800011435_4840576.0RegionNervy homology region 3 (NHR3)
TgeneCBFA2T2chr21:36231771chr20:32194762ENST00000492345213331_3770576.0RegionNervy homology region 2 (NHR2)
TgeneCBFA2T2chr21:36231771chr20:32194762ENST00000492345213435_4840576.0RegionNervy homology region 3 (NHR3)
TgeneCBFA2T2chr21:36231771chr20:32194762ENST00000342704011517_55311596.0Zinc fingerMYND-type
TgeneCBFA2T2chr21:36231771chr20:32194762ENST0000034420106517_5530264.0Zinc fingerMYND-type
TgeneCBFA2T2chr21:36231771chr20:32194762ENST00000346541112517_55320605.0Zinc fingerMYND-type
TgeneCBFA2T2chr21:36231771chr20:32194762ENST00000359606011517_55330615.0Zinc fingerMYND-type
TgeneCBFA2T2chr21:36231771chr20:32194762ENST00000375279112517_55320605.0Zinc fingerMYND-type
TgeneCBFA2T2chr21:36231771chr20:32194762ENST0000039779817517_5530264.0Zinc fingerMYND-type
TgeneCBFA2T2chr21:36231771chr20:32194762ENST00000397800011517_5530576.0Zinc fingerMYND-type
TgeneCBFA2T2chr21:36231771chr20:32194762ENST00000492345213517_5530576.0Zinc fingerMYND-type

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneRUNX1chr21:36231771chr20:32194762ENST00000300305-58187_453204481.0Compositional biasNote=Pro/Ser/Thr-rich
HgeneRUNX1chr21:36231771chr20:32194762ENST00000325074-47187_453192469.0Compositional biasNote=Pro/Ser/Thr-rich
HgeneRUNX1chr21:36231771chr20:32194762ENST00000344691-36187_453177454.0Compositional biasNote=Pro/Ser/Thr-rich
HgeneRUNX1chr21:36231771chr20:32194762ENST00000358356-35187_453177251.0Compositional biasNote=Pro/Ser/Thr-rich
HgeneRUNX1chr21:36231771chr20:32194762ENST00000437180-69187_453204481.0Compositional biasNote=Pro/Ser/Thr-rich


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Fusion Gene Sequence for RUNX1-CBFA2T2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>78645_78645_1_RUNX1-CBFA2T2_RUNX1_chr21_36231771_ENST00000300305_CBFA2T2_chr20_32194762_ENST00000342704_length(transcript)=3707nt_BP=1058nt
GGAAAGGGGAACAGTTAAATTTGTAATTTGGGTTGTGTGAAAACTTCTTTGGGCCTCATAAACAACCACAGAACCACAAGTTGGGTAGCC
TGGCAGTGTCAGAAGTCTGAACCCAGCATAGTGGTCAGCAGGCAGGACGAATCACACTGAATGCAAACCACAGGGTTTCGCAGCGTGGTG
AGCATCACCAACCCACAGCCAAGGCGGCGCTGGCTTTTTTTTTTTTTTTAATCTTTAACAATTTGAATATTTGTTTTTACAAAGGTGCAT
TTTTTAATAGGGCTTGGGGAGTCCCAGAGGTATCCAGCAGAGGGGAGAAGAAAGAGAGATGTAGGGCTAGAGGGGTGAGGCTGAAACAGT
GACCTGTCTTGGTTTTCGCTCCGAAGGTAAAAGAAATCATTGAGTCCCCCGCCTTCAGAAGAGGGTGCATTTTCAGGAGGAAGCGATGGC
TTCAGACAGCATATTTGAGTCATTTCCTTCGTACCCACAGTGCTTCATGAGAGAATGCATACTTGGAATGAATCCTTCTAGAGACGTCCA
CGATGCCAGCACGAGCCGCCGCTTCACGCCGCCTTCCACCGCGCTGAGCCCAGGCAAGATGAGCGAGGCGTTGCCGCTGGGCGCCCCGGA
CGCCGGCGCTGCCCTGGCCGGCAAGCTGAGGAGCGGCGACCGCAGCATGGTGGAGGTGCTGGCCGACCACCCGGGCGAGCTGGTGCGCAC
CGACAGCCCCAACTTCCTCTGCTCCGTGCTGCCTACGCACTGGCGCTGCAACAAGACCCTGCCCATCGCTTTCAAGGTGGTGGCCCTAGG
GGATGTTCCAGATGGCACTCTGGTCACTGTGATGGCTGGCAATGATGAAAACTACTCGGCTGAGCTGAGAAATGCTACCGCAGCCATGAA
GAACCAGGTTGCAAGATTTAATGACCTCAGGTTTGTCGGTCGAAGTGGAAGAGGGAAAAGCTTCACTCTGACCATCACTGTCTTCACAAA
CCCACCGCAAGTCGCCACCTACCACAGAGCCATCAAAATCACAGTGGATGGGCCCCGAGAACCTCGAATTGGTCCTGAGAAAAGGGTGCC
AGCGATGCCTGGATCGCCTGTGGAAGTGAAGATACAGTCCAGATCCTCACCTCCCACCATGCCACCCCTCCCACCAATAAATCCTGGAGG
ACCGAGGCCAGTGTCCTTCACTCCTACTGCATTAAGCAATGGCATCAACCATTCTCCTCCTACCCTGAATGGTGCCCCATCACCGCCACA
GAGATTCAGCAATGGTCCTGCCTCCTCCACATCATCTGCACTCACAAATCAGCAATTGCCAGCCACTTGTGGTGCTCGACAACTCAGCAA
GTTGAAACGCTTTCTTACCACTCTGCAACAGTTTGGCAATGACATCTCCCCTGAGATTGGGGAGAAGGTGCGGACTCTTGTTCTTGCACT
GGTGAACTCAACAGTGACAATTGAGGAATTCCACTGTAAGCTCCAAGAAGCCACAAACTTTCCCCTTCGTCCTTTTGTGATTCCATTTCT
CAAGGCCAACCTGCCCCTGCTGCAGCGGGAACTGCTGCACTGCGCTCGGGCGGCCAAGCAGACCCCATCCCAGTACCTGGCTCAGCACGA
ACACCTTCTGCTCAACACAAGCATTGCATCGCCTGCTGACTCGTCAGAGTTGCTCATGGAGGTGCACGGAAATGGGAAGAGGCCCAGTCC
AGAGAGGAGAGAAGAGAATAGTTTTGATAGAGACACAATTGCTCCTGAGCCTCCTGCCAAGAGAGTATGTACCATCAGCCCTGCTCCTCG
GCACAGTCCTGCTCTCACTGTGCCCCTCATGAATCCCGGGGGCCAATTCCATCCTACCCCTCCACCTCTTCAGCATTACACCTTAGAGGA
TATTGCAACTTCTCACCTGTATCGGGAACCCAACAAGATGCTAGAGCATCGAGAAGTTCGTGATAGACACCACAGTCTTGGTCTAAATGG
AGGCTATCAAGATGAGTTGGTAGATCATCGTTTGACAGAAAGGGAATGGGCTGATGAATGGAAACATCTTGACCATGCGCTGAATTGCAT
TATGGAAATGGTAGAGAAAACAAGGCGCTCTATGGCAGTTCTGCGGCGCTGTCAGGAATCAGATCGTGAAGAACTCAACTACTGGAAAAG
ACGGTACAATGAAAACACAGAGCTGAGGAAAACGGGGACCGAGTTGGTCTCCAGGCAGCACAGCCCTGGGAGTGCAGATTCTCTCAGCAA
TGATTCTCAGAGAGAGTTCAACAGCAGGCCAGGTACAGGATACGTACCTGTGGAGTTTTGGAAAAAAACAGAAGAAGCTGTGAATAAGGT
GAAAATTCAGGCCATGTCAGAAGTACAGAAGGCCGTCGCTGAGGCAGAGCAGAAAGCCTTTGAAGTGATTGCAACAGAGAGAGCACGAAT
GGAGCAAACCATAGCGGATGTCAAGCGGCAGGCCGCAGAGGATGCTTTCCTCGTCATCAATGAGCAAGAGGAGTCCACGGAGAACTGCTG
GAACTGTGGCCGCAAAGCCAGCGAGACATGCAGTGGCTGCAATATCGCGCGATACTGTGGCTCTTTCTGCCAGCACAAGGACTGGGAGCG
GCACCACCGCCTCTGTGGTCAGAACCTGCATGGCCAGAGCCCCCACGGCCAGGGCCGGCCGCTGCTTCCTGTAGGCAGGGGCTCCTCTGC
CAGGTCCGCCGACTGCAGCGTGCCCAGCCCAGCCCTCGACAAGACCTCGGCAACCACATCGCGTTCCTCAACACCTGCTTCTGTGACAGC
TATCGACACCAACGGACTCTGAGCCCCGGACTCTGCTTACCCTGATGGCTGCTCAGCACCACAGAGTGCTTGGGCTGAGGGACTGACTGT
TGGAACCCGTGCATGTAGCTGCCGGGTCATCAGCAAGAAATGAATTGGAGGCAGGAAGAGTCCAAGCCTGAATAATAACACCCCACAGCC
TCTCTGTGCACTTGCTGTCTGCGGAGCCAGTGTGCCATTCTCTGCACATGGGCAGCCAGCCTGAGCTGCCTCCTCCATGGCTTTCCTGGT
TTGTTCCTCTCTCCACTGAAGCTGACTTAGCCGGCCCCTTTTCAGTGTAGACCACCAGCTCCCCTCCCCATCTCCTTGAGTCAGCAGACT
GTCCAATGTGCTCAGCCAGGCTGGAGGCGGCAGGCGGCAGGCAGCAGGCTGTGGAGGAGGCCCCTCGGTCAGGGAGCGGCCTGCCTCACC
CCTGAATAGCTCCTTCGGCCCCATCTCCATCCTCAGCAGATGACACTGATTGGCCTCACGGGGACTTGGGTAAGCAACAGGCGGCATTCA
GGACTCTTCTCAACCCTGCTGTTCAGACTTGATAAGATCTCAGAGTCCACAGGAAAGAAGTCACTGTTGCAATAAAAGCACCCGTAGTAG
CAAAAACATAAAACAAATAAAACTTCCCCCACATCACAGATGATTTTGGACAAGATTTTCCAACCTTGCTGGCTACTTTAGTTTGGGACC
TGTTTTTTTTCTCATTTGATTTTGCTTGTGCAGAAAATAGTTTCCAGCACATGGATTGATCTGAGAGAGAATGAGGCTCAGTTGTGGATA
GTCTGTTTTCTCTGAGCATGTTGGCCAACTAGTATCGTCAAATTATTGAGTGGATCATCTCTTGGAAATGCAGAACTTCTGCCACCACTT

>78645_78645_1_RUNX1-CBFA2T2_RUNX1_chr21_36231771_ENST00000300305_CBFA2T2_chr20_32194762_ENST00000342704_length(amino acids)=788AA_BP=205
MASDSIFESFPSYPQCFMRECILGMNPSRDVHDASTSRRFTPPSTALSPGKMSEALPLGAPDAGAALAGKLRSGDRSMVEVLADHPGELV
RTDSPNFLCSVLPTHWRCNKTLPIAFKVVALGDVPDGTLVTVMAGNDENYSAELRNATAAMKNQVARFNDLRFVGRSGRGKSFTLTITVF
TNPPQVATYHRAIKITVDGPREPRIGPEKRVPAMPGSPVEVKIQSRSSPPTMPPLPPINPGGPRPVSFTPTALSNGINHSPPTLNGAPSP
PQRFSNGPASSTSSALTNQQLPATCGARQLSKLKRFLTTLQQFGNDISPEIGEKVRTLVLALVNSTVTIEEFHCKLQEATNFPLRPFVIP
FLKANLPLLQRELLHCARAAKQTPSQYLAQHEHLLLNTSIASPADSSELLMEVHGNGKRPSPERREENSFDRDTIAPEPPAKRVCTISPA
PRHSPALTVPLMNPGGQFHPTPPPLQHYTLEDIATSHLYREPNKMLEHREVRDRHHSLGLNGGYQDELVDHRLTEREWADEWKHLDHALN
CIMEMVEKTRRSMAVLRRCQESDREELNYWKRRYNENTELRKTGTELVSRQHSPGSADSLSNDSQREFNSRPGTGYVPVEFWKKTEEAVN
KVKIQAMSEVQKAVAEAEQKAFEVIATERARMEQTIADVKRQAAEDAFLVINEQEESTENCWNCGRKASETCSGCNIARYCGSFCQHKDW

--------------------------------------------------------------
>78645_78645_2_RUNX1-CBFA2T2_RUNX1_chr21_36231771_ENST00000300305_CBFA2T2_chr20_32194762_ENST00000375279_length(transcript)=8202nt_BP=1058nt
GGAAAGGGGAACAGTTAAATTTGTAATTTGGGTTGTGTGAAAACTTCTTTGGGCCTCATAAACAACCACAGAACCACAAGTTGGGTAGCC
TGGCAGTGTCAGAAGTCTGAACCCAGCATAGTGGTCAGCAGGCAGGACGAATCACACTGAATGCAAACCACAGGGTTTCGCAGCGTGGTG
AGCATCACCAACCCACAGCCAAGGCGGCGCTGGCTTTTTTTTTTTTTTTAATCTTTAACAATTTGAATATTTGTTTTTACAAAGGTGCAT
TTTTTAATAGGGCTTGGGGAGTCCCAGAGGTATCCAGCAGAGGGGAGAAGAAAGAGAGATGTAGGGCTAGAGGGGTGAGGCTGAAACAGT
GACCTGTCTTGGTTTTCGCTCCGAAGGTAAAAGAAATCATTGAGTCCCCCGCCTTCAGAAGAGGGTGCATTTTCAGGAGGAAGCGATGGC
TTCAGACAGCATATTTGAGTCATTTCCTTCGTACCCACAGTGCTTCATGAGAGAATGCATACTTGGAATGAATCCTTCTAGAGACGTCCA
CGATGCCAGCACGAGCCGCCGCTTCACGCCGCCTTCCACCGCGCTGAGCCCAGGCAAGATGAGCGAGGCGTTGCCGCTGGGCGCCCCGGA
CGCCGGCGCTGCCCTGGCCGGCAAGCTGAGGAGCGGCGACCGCAGCATGGTGGAGGTGCTGGCCGACCACCCGGGCGAGCTGGTGCGCAC
CGACAGCCCCAACTTCCTCTGCTCCGTGCTGCCTACGCACTGGCGCTGCAACAAGACCCTGCCCATCGCTTTCAAGGTGGTGGCCCTAGG
GGATGTTCCAGATGGCACTCTGGTCACTGTGATGGCTGGCAATGATGAAAACTACTCGGCTGAGCTGAGAAATGCTACCGCAGCCATGAA
GAACCAGGTTGCAAGATTTAATGACCTCAGGTTTGTCGGTCGAAGTGGAAGAGGGAAAAGCTTCACTCTGACCATCACTGTCTTCACAAA
CCCACCGCAAGTCGCCACCTACCACAGAGCCATCAAAATCACAGTGGATGGGCCCCGAGAACCTCGAATTGGTCCTGAGAAAAGGGTGCC
AGCGATGCCTGGATCGCCTGTGGAAGTGAAGATACAGTCCAGATCCTCACCTCCCACCATGCCACCCCTCCCACCAATAAATCCTGGAGG
ACCGAGGCCAGTGTCCTTCACTCCTACTGCATTAAGCAATGGCATCAACCATTCTCCTCCTACCCTGAATGGTGCCCCATCACCGCCACA
GAGATTCAGCAATGGTCCTGCCTCCTCCACATCATCTGCACTCACAAATCAGCAATTGCCAGCCACTTGTGGTGCTCGACAACTCAGCAA
GTTGAAACGCTTTCTTACCACTCTGCAACAGTTTGGCAATGACATCTCCCCTGAGATTGGGGAGAAGGTGCGGACTCTTGTTCTTGCACT
GGTGAACTCAACAGTGACAATTGAGGAATTCCACTGTAAGCTCCAAGAAGCCACAAACTTTCCCCTTCGTCCTTTTGTGATTCCATTTCT
CAAGGCCAACCTGCCCCTGCTGCAGCGGGAACTGCTGCACTGCGCTCGGGCGGCCAAGCAGACCCCATCCCAGTACCTGGCTCAGCACGA
ACACCTTCTGCTCAACACAAGCATTGCATCGCCTGCTGACTCGTCAGAGTTGCTCATGGAGGTGCACGGAAATGGGAAGAGGCCCAGTCC
AGAGAGGAGAGAAGAGAATAGTTTTGATAGAGACACAATTGCTCCTGAGCCTCCTGCCAAGAGAGTATGTACCATCAGCCCTGCTCCTCG
GCACAGTCCTGCTCTCACTGTGCCCCTCATGAATCCCGGGGGCCAATTCCATCCTACCCCTCCACCTCTTCAGCATTACACCTTAGAGGA
TATTGCAACTTCTCACCTGTATCGGGAACCCAACAAGATGCTAGAGCATCGAGAAGTTCGTGATAGACACCACAGTCTTGGTCTAAATGG
AGGCTATCAAGATGAGTTGGTAGATCATCGTTTGACAGAAAGGGAATGGGCTGATGAATGGAAACATCTTGACCATGCGCTGAATTGCAT
TATGGAAATGGTAGAGAAAACAAGGCGCTCTATGGCAGTTCTGCGGCGCTGTCAGGAATCAGATCGTGAAGAACTCAACTACTGGAAAAG
ACGGTACAATGAAAACACAGAGCTGAGGAAAACGGGGACCGAGTTGGTCTCCAGGCAGCACAGCCCTGGGAGTGCAGATTCTCTCAGCAA
TGATTCTCAGAGAGAGTTCAACAGCAGGCCAGGTACAGGATACGTACCTGTGGAGTTTTGGAAAAAAACAGAAGAAGCTGTGAATAAGGT
GAAAATTCAGGCCATGTCAGAAGTACAGAAGGCCGTCGCTGAGGCAGAGCAGAAAGCCTTTGAAGTGATTGCAACAGAGAGAGCACGAAT
GGAGCAAACCATAGCGGATGTCAAGCGGCAGGCCGCAGAGGATGCTTTCCTCGTCATCAATGAGCAAGAGGAGTCCACGGAGAACTGCTG
GAACTGTGGCCGCAAAGCCAGCGAGACATGCAGTGGCTGCAATATCGCGCGATACTGTGGCTCTTTCTGCCAGCACAAGGACTGGGAGCG
GCACCACCGCCTCTGTGGTCAGAACCTGCATGGCCAGAGCCCCCACGGCCAGGGCCGGCCGCTGCTTCCTGTAGGCAGGGGCTCCTCTGC
CAGGTCCGCCGACTGCAGCGTGCCCAGCCCAGCCCTCGACAAGACCTCGGCAACCACATCGCGTTCCTCAACACCTGCTTCTGTGACAGC
TATCGACACCAACGGACTCTGAGCCCCGGACTCTGCTTACCCTGATGGCTGCTCAGCACCACAGAGTGCTTGGGCTGAGGGACTGACTGT
TGGAACCCGTGCATGTAGCTGCCGGGTCATCAGCAAGAAATGAATTGGAGGCAGGAAGAGTCCAAGCCTGAATAATAACACCCCACAGCC
TCTCTGTGCACTTGCTGTCTGCGGAGCCAGTGTGCCATTCTCTGCACATGGGCAGCCAGCCTGAGCTGCCTCCTCCATGGCTTTCCTGGT
TTGTTCCTCTCTCCACTGAAGCTGACTTAGCCGGCCCCTTTTCAGTGTAGACCACCAGCTCCCCTCCCCATCTCCTTGAGTCAGCAGACT
GTCCAATGTGCTCAGCCAGGCTGGAGGCGGCAGGCGGCAGGCAGCAGGCTGTGGAGGAGGCCCCTCGGTCAGGGAGCGGCCTGCCTCACC
CCTGAATAGCTCCTTCGGCCCCATCTCCATCCTCAGCAGATGACACTGATTGGCCTCACGGGGACTTGGGTAAGCAACAGGCGGCATTCA
GGACTCTTCTCAACCCTGCTGTTCAGACTTGATAAGATCTCAGAGTCCACAGGAAAGAAGTCACTGTTGCAATAAAAGCACCCGTAGTAG
CAAAAACATAAAACAAATAAAACTTCCCCCACATCACAGATGATTTTGGACAAGATTTTCCAACCTTGCTGGCTACTTTAGTTTGGGACC
TGTTTTTTTTCTCATTTGATTTTGCTTGTGCAGAAAATAGTTTCCAGCACATGGATTGATCTGAGAGAGAATGAGGCTCAGTTGTGGATA
GTCTGTTTTCTCTGAGCATGTTGGCCAACTAGTATCGTCAAATTATTGAGTGGATCATCTCTTGGAAATGCAGAACTTCTGCCACCACTT
GGCTATTTGCACAGTCATCTTGTTCTGTGTCCTTTTATCTCTCAGACCACACACATCTGGAACGCTGTGGGCATCTTCTGCCCATGGGCT
CCATTTGGCACCTGCTGAGCCACAGTTGTCCTGCTGGATGTGCTGTGCAGGTTGGTAGGACTTGCCCCCACTGTCAAGGCCTGGTCTCAT
CTGAAAAGCCCTCCTGGACCTCAAAGAATTCTTCAGACCTCATAGTTACAGGTCATTATATCTACTATGTTGATTTATCATCAGGCACAC
AACTTCTGTTTCCTTCTCTTGTGTTATCTGATAGCGTCCCTCCTTGAGCTCATCAGAAAGGTTTTATGAAATGTGAACCATTTTGGGAAA
AGCTGATCAATTTTTCTTCCTAGCTTCCCATTTTCAAATGGGACATCACTCATATCCCTTTCAGAATGTTAGGAACTGCCTCCCACATTC
TTCCCTGTCTTTTTGGGTTTTGTTTTTTGTTGTTGTGGTGGTTTTTTAACACAAAGTCTCACTCTGTTGCCCAGGCTGGAGTGCAGTGGC
ATGATCTTGGCTCACTGCAACCTCTGCCTTCCAGGTTCAAGCAATTCTCCTGCCTCAGCCTCCCGAGTAGCTGAGATTACAGGCGCCCAC
CACCACGCCCAGCTAATTTTTGTATTTTTAGTAGAGACAGGGTTTCACCATGTTGGCCAGGCTGATCTCGAACTCCTGACCTCAGGTGAC
CTGCCTTGGCCTCCCAAAGTGCAGGGATTACAAGCGTGAGCCACCATGCCCGGCCTGTCTTTTTGGTTTTGATGGGAGTCTGAGGACCCC
GACCCCTCCTGCTCTCCATCTTTGAGCCTCTGGCATCCTCTCACACCCAGAAATCAGTTGGAGTAAGTTTAATTGGCCCTGCTCCAGCTG
GCCTTTGAAGCACAAGTTTAAATCTCCACCTTCTGTGCACTGACCAGAGTCTAAAATAAAAGTTGTCAGTACCATAAAGGAAAAGGGATC
CACACAGGTAGCCTTCTCCTTGGATACAGGTACATCTTACTGTAAGAATTTCAAGTCCTGGCTGGGCGCAGTGGCTCACTCCTGTAATCC
CAGCACTTTGAGAGACCGAGGCAGGCAGATCACTTGAGGTCAGGAATTCAAGACCAACCTGGCCAACATGGTGAAACCCTGTCTCTAATA
AAAAAAAAATAGAAAAATCAGCCGGGTGTGGTGGCACACACCTGTAATCCTAGCTACTCAGGAGGCTGAGGCAAGAGAATCTCTTGAACC
TGTGAGCCAGAGGTTGCAGTGAGCCGAGATTCCACCACTGCACTCCAGCCTGGGCAACAGAGCAAAACTCTGTCTCAAAAAAAAAAAAAA
AAAGGCAAAATTAAAGAATTTCAAGTCCCTAATTTACTCTAACCAAGCATTTTCAGTCTTACAAAGAAATCTAGTGCACGACACCTTTAA
AATGCCTAGATTTCCATTGCCTAAAGTAAGGTGTGACCAGTGAAACAACAGCAGAGAATCATGTTCCTTTGCTGTGGAACACATAAGCCC
CACAGTTTTCCAGTCAGCCTAATACATGGGTATCCCCCGACCCCATCTGCCTCCTTAAGCCACAGTCCTTGGTGGGGAACTCTAAGGGGG
ACGGAGTCAGTACCCCGGACAGGGCCACATTTGCATGAGACATGGCTGTCTCACAGGTCACAGAGCCATTACAACAGCTTACTAGTTTTT
CATGGATTTGTTGGATTAACACCTTAAGCAGGTTTTTTATTGTTATTTTGTTTGTTTGTTTGTTTTGAGACGGGAGTTTCTCTCTTGTCT
CCCAGGCTGGAGTGCAATCGCGCAATCTCGGCTCACGGTAACCTCTGCCTCCCAGGTTCAAGCGAGTCTCCTGCCTCAGCCTTCTGAGTA
GCTGGGATTACAGGCATGCGCCACCACGCCCAACTAATTTTGTATTTTTAGTAGAGACGGGGTTTCTCCTTGTTGGTCAGGCTGGTCTCA
AACCCCGGACCTCAGGTGATCCCCCCACCTTGGCCTCCCAAAGTGCCAGGATTACAGGCATGAGCCACTGTGTCCGGTCTTGAGCAGGTT
TTTAAAATCTCCAGTGGCCATAAAACTAGCCAGGGTAGCTCATGCTTTTACTGGTTGGAATAAGGAGCCAAAACCAACAAAATAATATTT
ATTAGGGCTCGATGCCCATTTCTGTGGCTAAGGCTTAGGTTTGGTGTGCAGAGCCTGGCCTGCTCTTGTGGGCTGTGGTTGCTGTGACAG
TTTCGTTTTCTGAATCTTTGTAATGCTCTTCCACCCTGCTCGTGCTGCCCAGAGGCTGATCTGCAAACCTGGGCAGTATTCCACACTGAA
GCTCAGTTTGCAAACCTTCTGCTGTGTTAATTCTGGTCAGTTTCACACAGAAGTCACGAGGGCCTCTGCCCAGGACCTTCTATTCACATT
TCAAGAATCCCTTTCTGAAATTCTCCAACTCTCTGGTCAGGAGGAGGAGCACCATTGGGGCGGGGTAGGCAGCTAGAGGCGCAGGAGCGA
ATCCAGGTTCCTTGCGTGGTTCCCAGCCTCTGCTGACAGCACCTCAGCTACCAGGTGGGGAGTGGAAATTCAGCCTGCTTAGAGGACTGA
CCTCTACAGTTCATATTTGCAGTGACATAAAAGGCAAAGAGGAGCTGGCATGGTGGTACAGAAGGTATCAGTCAAGCGCAGGCTCTTCAG
AAACCTAGAAACTAAAAAGAGATGCAACATGTGACTGGCCATCAGCCAGACATGTCTAGGGTGAGACCAGTGCTCAGCACCACCCGCCAA
GGAACACTGATGAGTTGTGGGACATTATGGTCGGCCAAGTGAGGAATGATTGCAGGGACCAGAGAAGACCAAAGATGCCAGATGTCCCCA
GAGTTTCTTGAGGGCTGGGTTTCACGTCTTTGCTTGTCCTTTTTGTCCCCACTTGCCTGCACCGTGCCTGACTCATCCAGTGGGGAAGGT
GACTCAAGAAGTTGTTTAAGCCTAGGCCTAGGCAGTCCACTTCGGGAGGTGGGGGCACTCCACACTGGGGGGCCCTGCAGCTCCAGGGCT
GGTGCTCTAGCAGATCCGCTCAGGCACGGTTGGGTGACCGTGGGGTCACCGATTGCGTAGATTATTTCTAGGGCAGTGCTGGGTTAGAAA
TGTCTGTCTGGAAACAGGACACATCTTGCCACCACAAGTCCACACCTGGCCTTGGCTGCTGCCCGCTCTCTGCAGCGTGGATTTCCTTTG
CCCATTTGGGCCAGAAGGTCACCAGGAGTTCATCACTGCTTAGTGTCAACTTGACATCTTCAGCTTCCAGACAGAAAACCCATGCTTTAC
TTTGTACAGCCCTGTCCCAGAGTTAGTAAGCCTCGGCTTGTCACCTGCTTGCAAAGGGTATAGACATCATTCTGGGTAGTTCTAGAGGAT
ATCGCAACAAGTGCGTTTGAAGGTTCAGCACAGCTGGAATTGTACGGTAGTGAGCTCTTCAAAATGAAAACAGAATGACCGGATGGCCAT
CTGTCCTGGAAACTGTAGAATTGAATAAATCACTGAAAATAGAACACTTCTTGGAGGCTTTCTTCAGAACTGAACTAGAAACAAGGTTTC
CAGGCTCCCAGGTCAGTAGACCAAACCAACTTCCTTAGATTTTTTTTTTTAAGCTGTTTGCAGAAAACTGGGTGGTAGCGTGTCTGAACC
AAACGGAAGAATAGCCAGCGGAGCATGGACTGTTCCAGCACGGGCCAGATGGCCAGCTGTCGAGAGCAGCCCTGCCCAGATTGCGGTGGG
GGCTGTGCCAGCGGCTCCGCAGGGCCCTTCCAACTCTGGAGTGTCTGTAGTTCTTGTGAAACCAAAACGTTGACTACCTGCCTCTTTCCT
CGGGCATCGACGTGCTCATTTCCAAAGATGATGGTGCAGGTGACCTTTTCCATCGTGAGCTAAGAGAAGGTTAGGAGGCCTGAGGGGCGG
GCCTTGTGTCCCCTCCTCCCCCTCCACAGCCCCTGAGGTGGAGCTTCCCTCACAGACCCCATCTGGTCGAGCCTACGGCTGCCCAGTGTA
CACTCAGTGATGCTTATACCAAATAGGGCATGTGCGCTGGTGTCTGTTGGGGACAGCCCCATCCCTACCTTGGAGTCGGCAGAGAAGCAG
CAATAAGCATTAGGCGAATGATTGAAAGGGCTGCTGCGCCAAGAGGCCTTCAGTCCCCTTAACGTGGCTTTCCAACTTCCTGACGAGGCT
ACAAAGGCTCCGCTCACAAAAGAAAGCCAATAATGTAAATAAATAGAAAACGAAGCCTCCACGCGTGGTTTTTAAAGGGGGATGATGAAT
GTGACACCACCCACAGAATGCATTAGAATCTGGTTTTTCTGTGCTTTGTCATTTTACTCTGATAGGAATTTTTGTTACCTAACTCTGTGC
ATAACTTATTTAATGTACTGTATAAATGAACCAAAACTGTTAAATATGTATTTAGTTTGTTCTACTTAAAGTAGTCAATAAAAAGGCTAT

>78645_78645_2_RUNX1-CBFA2T2_RUNX1_chr21_36231771_ENST00000300305_CBFA2T2_chr20_32194762_ENST00000375279_length(amino acids)=788AA_BP=205
MASDSIFESFPSYPQCFMRECILGMNPSRDVHDASTSRRFTPPSTALSPGKMSEALPLGAPDAGAALAGKLRSGDRSMVEVLADHPGELV
RTDSPNFLCSVLPTHWRCNKTLPIAFKVVALGDVPDGTLVTVMAGNDENYSAELRNATAAMKNQVARFNDLRFVGRSGRGKSFTLTITVF
TNPPQVATYHRAIKITVDGPREPRIGPEKRVPAMPGSPVEVKIQSRSSPPTMPPLPPINPGGPRPVSFTPTALSNGINHSPPTLNGAPSP
PQRFSNGPASSTSSALTNQQLPATCGARQLSKLKRFLTTLQQFGNDISPEIGEKVRTLVLALVNSTVTIEEFHCKLQEATNFPLRPFVIP
FLKANLPLLQRELLHCARAAKQTPSQYLAQHEHLLLNTSIASPADSSELLMEVHGNGKRPSPERREENSFDRDTIAPEPPAKRVCTISPA
PRHSPALTVPLMNPGGQFHPTPPPLQHYTLEDIATSHLYREPNKMLEHREVRDRHHSLGLNGGYQDELVDHRLTEREWADEWKHLDHALN
CIMEMVEKTRRSMAVLRRCQESDREELNYWKRRYNENTELRKTGTELVSRQHSPGSADSLSNDSQREFNSRPGTGYVPVEFWKKTEEAVN
KVKIQAMSEVQKAVAEAEQKAFEVIATERARMEQTIADVKRQAAEDAFLVINEQEESTENCWNCGRKASETCSGCNIARYCGSFCQHKDW

--------------------------------------------------------------
>78645_78645_3_RUNX1-CBFA2T2_RUNX1_chr21_36231771_ENST00000325074_CBFA2T2_chr20_32194762_ENST00000342704_length(transcript)=3226nt_BP=577nt
ATGCCCGCAGCACCGCGGGGACCGGCGCAGGGGGAAGCGGCCGCCCGCACGCGAAGCCGGGATGCCAGCACGAGCCGCCGCTTCACGCCG
CCTTCCACCGCGCTGAGCCCAGGCAAGATGAGCGAGGCGTTGCCGCTGGGCGCCCCGGACGCCGGCGCTGCCCTGGCCGGCAAGCTGAGG
AGCGGCGACCGCAGCATGGTGGAGGTGCTGGCCGACCACCCGGGCGAGCTGGTGCGCACCGACAGCCCCAACTTCCTCTGCTCCGTGCTG
CCTACGCACTGGCGCTGCAACAAGACCCTGCCCATCGCTTTCAAGGTGGTGGCCCTAGGGGATGTTCCAGATGGCACTCTGGTCACTGTG
ATGGCTGGCAATGATGAAAACTACTCGGCTGAGCTGAGAAATGCTACCGCAGCCATGAAGAACCAGGTTGCAAGATTTAATGACCTCAGG
TTTGTCGGTCGAAGTGGAAGAGGGAAAAGCTTCACTCTGACCATCACTGTCTTCACAAACCCACCGCAAGTCGCCACCTACCACAGAGCC
ATCAAAATCACAGTGGATGGGCCCCGAGAACCTCGAATTGGTCCTGAGAAAAGGGTGCCAGCGATGCCTGGATCGCCTGTGGAAGTGAAG
ATACAGTCCAGATCCTCACCTCCCACCATGCCACCCCTCCCACCAATAAATCCTGGAGGACCGAGGCCAGTGTCCTTCACTCCTACTGCA
TTAAGCAATGGCATCAACCATTCTCCTCCTACCCTGAATGGTGCCCCATCACCGCCACAGAGATTCAGCAATGGTCCTGCCTCCTCCACA
TCATCTGCACTCACAAATCAGCAATTGCCAGCCACTTGTGGTGCTCGACAACTCAGCAAGTTGAAACGCTTTCTTACCACTCTGCAACAG
TTTGGCAATGACATCTCCCCTGAGATTGGGGAGAAGGTGCGGACTCTTGTTCTTGCACTGGTGAACTCAACAGTGACAATTGAGGAATTC
CACTGTAAGCTCCAAGAAGCCACAAACTTTCCCCTTCGTCCTTTTGTGATTCCATTTCTCAAGGCCAACCTGCCCCTGCTGCAGCGGGAA
CTGCTGCACTGCGCTCGGGCGGCCAAGCAGACCCCATCCCAGTACCTGGCTCAGCACGAACACCTTCTGCTCAACACAAGCATTGCATCG
CCTGCTGACTCGTCAGAGTTGCTCATGGAGGTGCACGGAAATGGGAAGAGGCCCAGTCCAGAGAGGAGAGAAGAGAATAGTTTTGATAGA
GACACAATTGCTCCTGAGCCTCCTGCCAAGAGAGTATGTACCATCAGCCCTGCTCCTCGGCACAGTCCTGCTCTCACTGTGCCCCTCATG
AATCCCGGGGGCCAATTCCATCCTACCCCTCCACCTCTTCAGCATTACACCTTAGAGGATATTGCAACTTCTCACCTGTATCGGGAACCC
AACAAGATGCTAGAGCATCGAGAAGTTCGTGATAGACACCACAGTCTTGGTCTAAATGGAGGCTATCAAGATGAGTTGGTAGATCATCGT
TTGACAGAAAGGGAATGGGCTGATGAATGGAAACATCTTGACCATGCGCTGAATTGCATTATGGAAATGGTAGAGAAAACAAGGCGCTCT
ATGGCAGTTCTGCGGCGCTGTCAGGAATCAGATCGTGAAGAACTCAACTACTGGAAAAGACGGTACAATGAAAACACAGAGCTGAGGAAA
ACGGGGACCGAGTTGGTCTCCAGGCAGCACAGCCCTGGGAGTGCAGATTCTCTCAGCAATGATTCTCAGAGAGAGTTCAACAGCAGGCCA
GGTACAGGATACGTACCTGTGGAGTTTTGGAAAAAAACAGAAGAAGCTGTGAATAAGGTGAAAATTCAGGCCATGTCAGAAGTACAGAAG
GCCGTCGCTGAGGCAGAGCAGAAAGCCTTTGAAGTGATTGCAACAGAGAGAGCACGAATGGAGCAAACCATAGCGGATGTCAAGCGGCAG
GCCGCAGAGGATGCTTTCCTCGTCATCAATGAGCAAGAGGAGTCCACGGAGAACTGCTGGAACTGTGGCCGCAAAGCCAGCGAGACATGC
AGTGGCTGCAATATCGCGCGATACTGTGGCTCTTTCTGCCAGCACAAGGACTGGGAGCGGCACCACCGCCTCTGTGGTCAGAACCTGCAT
GGCCAGAGCCCCCACGGCCAGGGCCGGCCGCTGCTTCCTGTAGGCAGGGGCTCCTCTGCCAGGTCCGCCGACTGCAGCGTGCCCAGCCCA
GCCCTCGACAAGACCTCGGCAACCACATCGCGTTCCTCAACACCTGCTTCTGTGACAGCTATCGACACCAACGGACTCTGAGCCCCGGAC
TCTGCTTACCCTGATGGCTGCTCAGCACCACAGAGTGCTTGGGCTGAGGGACTGACTGTTGGAACCCGTGCATGTAGCTGCCGGGTCATC
AGCAAGAAATGAATTGGAGGCAGGAAGAGTCCAAGCCTGAATAATAACACCCCACAGCCTCTCTGTGCACTTGCTGTCTGCGGAGCCAGT
GTGCCATTCTCTGCACATGGGCAGCCAGCCTGAGCTGCCTCCTCCATGGCTTTCCTGGTTTGTTCCTCTCTCCACTGAAGCTGACTTAGC
CGGCCCCTTTTCAGTGTAGACCACCAGCTCCCCTCCCCATCTCCTTGAGTCAGCAGACTGTCCAATGTGCTCAGCCAGGCTGGAGGCGGC
AGGCGGCAGGCAGCAGGCTGTGGAGGAGGCCCCTCGGTCAGGGAGCGGCCTGCCTCACCCCTGAATAGCTCCTTCGGCCCCATCTCCATC
CTCAGCAGATGACACTGATTGGCCTCACGGGGACTTGGGTAAGCAACAGGCGGCATTCAGGACTCTTCTCAACCCTGCTGTTCAGACTTG
ATAAGATCTCAGAGTCCACAGGAAAGAAGTCACTGTTGCAATAAAAGCACCCGTAGTAGCAAAAACATAAAACAAATAAAACTTCCCCCA
CATCACAGATGATTTTGGACAAGATTTTCCAACCTTGCTGGCTACTTTAGTTTGGGACCTGTTTTTTTTCTCATTTGATTTTGCTTGTGC
AGAAAATAGTTTCCAGCACATGGATTGATCTGAGAGAGAATGAGGCTCAGTTGTGGATAGTCTGTTTTCTCTGAGCATGTTGGCCAACTA

>78645_78645_3_RUNX1-CBFA2T2_RUNX1_chr21_36231771_ENST00000325074_CBFA2T2_chr20_32194762_ENST00000342704_length(amino acids)=776AA_BP=193
MPAAPRGPAQGEAAARTRSRDASTSRRFTPPSTALSPGKMSEALPLGAPDAGAALAGKLRSGDRSMVEVLADHPGELVRTDSPNFLCSVL
PTHWRCNKTLPIAFKVVALGDVPDGTLVTVMAGNDENYSAELRNATAAMKNQVARFNDLRFVGRSGRGKSFTLTITVFTNPPQVATYHRA
IKITVDGPREPRIGPEKRVPAMPGSPVEVKIQSRSSPPTMPPLPPINPGGPRPVSFTPTALSNGINHSPPTLNGAPSPPQRFSNGPASST
SSALTNQQLPATCGARQLSKLKRFLTTLQQFGNDISPEIGEKVRTLVLALVNSTVTIEEFHCKLQEATNFPLRPFVIPFLKANLPLLQRE
LLHCARAAKQTPSQYLAQHEHLLLNTSIASPADSSELLMEVHGNGKRPSPERREENSFDRDTIAPEPPAKRVCTISPAPRHSPALTVPLM
NPGGQFHPTPPPLQHYTLEDIATSHLYREPNKMLEHREVRDRHHSLGLNGGYQDELVDHRLTEREWADEWKHLDHALNCIMEMVEKTRRS
MAVLRRCQESDREELNYWKRRYNENTELRKTGTELVSRQHSPGSADSLSNDSQREFNSRPGTGYVPVEFWKKTEEAVNKVKIQAMSEVQK
AVAEAEQKAFEVIATERARMEQTIADVKRQAAEDAFLVINEQEESTENCWNCGRKASETCSGCNIARYCGSFCQHKDWERHHRLCGQNLH

--------------------------------------------------------------
>78645_78645_4_RUNX1-CBFA2T2_RUNX1_chr21_36231771_ENST00000325074_CBFA2T2_chr20_32194762_ENST00000375279_length(transcript)=7721nt_BP=577nt
ATGCCCGCAGCACCGCGGGGACCGGCGCAGGGGGAAGCGGCCGCCCGCACGCGAAGCCGGGATGCCAGCACGAGCCGCCGCTTCACGCCG
CCTTCCACCGCGCTGAGCCCAGGCAAGATGAGCGAGGCGTTGCCGCTGGGCGCCCCGGACGCCGGCGCTGCCCTGGCCGGCAAGCTGAGG
AGCGGCGACCGCAGCATGGTGGAGGTGCTGGCCGACCACCCGGGCGAGCTGGTGCGCACCGACAGCCCCAACTTCCTCTGCTCCGTGCTG
CCTACGCACTGGCGCTGCAACAAGACCCTGCCCATCGCTTTCAAGGTGGTGGCCCTAGGGGATGTTCCAGATGGCACTCTGGTCACTGTG
ATGGCTGGCAATGATGAAAACTACTCGGCTGAGCTGAGAAATGCTACCGCAGCCATGAAGAACCAGGTTGCAAGATTTAATGACCTCAGG
TTTGTCGGTCGAAGTGGAAGAGGGAAAAGCTTCACTCTGACCATCACTGTCTTCACAAACCCACCGCAAGTCGCCACCTACCACAGAGCC
ATCAAAATCACAGTGGATGGGCCCCGAGAACCTCGAATTGGTCCTGAGAAAAGGGTGCCAGCGATGCCTGGATCGCCTGTGGAAGTGAAG
ATACAGTCCAGATCCTCACCTCCCACCATGCCACCCCTCCCACCAATAAATCCTGGAGGACCGAGGCCAGTGTCCTTCACTCCTACTGCA
TTAAGCAATGGCATCAACCATTCTCCTCCTACCCTGAATGGTGCCCCATCACCGCCACAGAGATTCAGCAATGGTCCTGCCTCCTCCACA
TCATCTGCACTCACAAATCAGCAATTGCCAGCCACTTGTGGTGCTCGACAACTCAGCAAGTTGAAACGCTTTCTTACCACTCTGCAACAG
TTTGGCAATGACATCTCCCCTGAGATTGGGGAGAAGGTGCGGACTCTTGTTCTTGCACTGGTGAACTCAACAGTGACAATTGAGGAATTC
CACTGTAAGCTCCAAGAAGCCACAAACTTTCCCCTTCGTCCTTTTGTGATTCCATTTCTCAAGGCCAACCTGCCCCTGCTGCAGCGGGAA
CTGCTGCACTGCGCTCGGGCGGCCAAGCAGACCCCATCCCAGTACCTGGCTCAGCACGAACACCTTCTGCTCAACACAAGCATTGCATCG
CCTGCTGACTCGTCAGAGTTGCTCATGGAGGTGCACGGAAATGGGAAGAGGCCCAGTCCAGAGAGGAGAGAAGAGAATAGTTTTGATAGA
GACACAATTGCTCCTGAGCCTCCTGCCAAGAGAGTATGTACCATCAGCCCTGCTCCTCGGCACAGTCCTGCTCTCACTGTGCCCCTCATG
AATCCCGGGGGCCAATTCCATCCTACCCCTCCACCTCTTCAGCATTACACCTTAGAGGATATTGCAACTTCTCACCTGTATCGGGAACCC
AACAAGATGCTAGAGCATCGAGAAGTTCGTGATAGACACCACAGTCTTGGTCTAAATGGAGGCTATCAAGATGAGTTGGTAGATCATCGT
TTGACAGAAAGGGAATGGGCTGATGAATGGAAACATCTTGACCATGCGCTGAATTGCATTATGGAAATGGTAGAGAAAACAAGGCGCTCT
ATGGCAGTTCTGCGGCGCTGTCAGGAATCAGATCGTGAAGAACTCAACTACTGGAAAAGACGGTACAATGAAAACACAGAGCTGAGGAAA
ACGGGGACCGAGTTGGTCTCCAGGCAGCACAGCCCTGGGAGTGCAGATTCTCTCAGCAATGATTCTCAGAGAGAGTTCAACAGCAGGCCA
GGTACAGGATACGTACCTGTGGAGTTTTGGAAAAAAACAGAAGAAGCTGTGAATAAGGTGAAAATTCAGGCCATGTCAGAAGTACAGAAG
GCCGTCGCTGAGGCAGAGCAGAAAGCCTTTGAAGTGATTGCAACAGAGAGAGCACGAATGGAGCAAACCATAGCGGATGTCAAGCGGCAG
GCCGCAGAGGATGCTTTCCTCGTCATCAATGAGCAAGAGGAGTCCACGGAGAACTGCTGGAACTGTGGCCGCAAAGCCAGCGAGACATGC
AGTGGCTGCAATATCGCGCGATACTGTGGCTCTTTCTGCCAGCACAAGGACTGGGAGCGGCACCACCGCCTCTGTGGTCAGAACCTGCAT
GGCCAGAGCCCCCACGGCCAGGGCCGGCCGCTGCTTCCTGTAGGCAGGGGCTCCTCTGCCAGGTCCGCCGACTGCAGCGTGCCCAGCCCA
GCCCTCGACAAGACCTCGGCAACCACATCGCGTTCCTCAACACCTGCTTCTGTGACAGCTATCGACACCAACGGACTCTGAGCCCCGGAC
TCTGCTTACCCTGATGGCTGCTCAGCACCACAGAGTGCTTGGGCTGAGGGACTGACTGTTGGAACCCGTGCATGTAGCTGCCGGGTCATC
AGCAAGAAATGAATTGGAGGCAGGAAGAGTCCAAGCCTGAATAATAACACCCCACAGCCTCTCTGTGCACTTGCTGTCTGCGGAGCCAGT
GTGCCATTCTCTGCACATGGGCAGCCAGCCTGAGCTGCCTCCTCCATGGCTTTCCTGGTTTGTTCCTCTCTCCACTGAAGCTGACTTAGC
CGGCCCCTTTTCAGTGTAGACCACCAGCTCCCCTCCCCATCTCCTTGAGTCAGCAGACTGTCCAATGTGCTCAGCCAGGCTGGAGGCGGC
AGGCGGCAGGCAGCAGGCTGTGGAGGAGGCCCCTCGGTCAGGGAGCGGCCTGCCTCACCCCTGAATAGCTCCTTCGGCCCCATCTCCATC
CTCAGCAGATGACACTGATTGGCCTCACGGGGACTTGGGTAAGCAACAGGCGGCATTCAGGACTCTTCTCAACCCTGCTGTTCAGACTTG
ATAAGATCTCAGAGTCCACAGGAAAGAAGTCACTGTTGCAATAAAAGCACCCGTAGTAGCAAAAACATAAAACAAATAAAACTTCCCCCA
CATCACAGATGATTTTGGACAAGATTTTCCAACCTTGCTGGCTACTTTAGTTTGGGACCTGTTTTTTTTCTCATTTGATTTTGCTTGTGC
AGAAAATAGTTTCCAGCACATGGATTGATCTGAGAGAGAATGAGGCTCAGTTGTGGATAGTCTGTTTTCTCTGAGCATGTTGGCCAACTA
GTATCGTCAAATTATTGAGTGGATCATCTCTTGGAAATGCAGAACTTCTGCCACCACTTGGCTATTTGCACAGTCATCTTGTTCTGTGTC
CTTTTATCTCTCAGACCACACACATCTGGAACGCTGTGGGCATCTTCTGCCCATGGGCTCCATTTGGCACCTGCTGAGCCACAGTTGTCC
TGCTGGATGTGCTGTGCAGGTTGGTAGGACTTGCCCCCACTGTCAAGGCCTGGTCTCATCTGAAAAGCCCTCCTGGACCTCAAAGAATTC
TTCAGACCTCATAGTTACAGGTCATTATATCTACTATGTTGATTTATCATCAGGCACACAACTTCTGTTTCCTTCTCTTGTGTTATCTGA
TAGCGTCCCTCCTTGAGCTCATCAGAAAGGTTTTATGAAATGTGAACCATTTTGGGAAAAGCTGATCAATTTTTCTTCCTAGCTTCCCAT
TTTCAAATGGGACATCACTCATATCCCTTTCAGAATGTTAGGAACTGCCTCCCACATTCTTCCCTGTCTTTTTGGGTTTTGTTTTTTGTT
GTTGTGGTGGTTTTTTAACACAAAGTCTCACTCTGTTGCCCAGGCTGGAGTGCAGTGGCATGATCTTGGCTCACTGCAACCTCTGCCTTC
CAGGTTCAAGCAATTCTCCTGCCTCAGCCTCCCGAGTAGCTGAGATTACAGGCGCCCACCACCACGCCCAGCTAATTTTTGTATTTTTAG
TAGAGACAGGGTTTCACCATGTTGGCCAGGCTGATCTCGAACTCCTGACCTCAGGTGACCTGCCTTGGCCTCCCAAAGTGCAGGGATTAC
AAGCGTGAGCCACCATGCCCGGCCTGTCTTTTTGGTTTTGATGGGAGTCTGAGGACCCCGACCCCTCCTGCTCTCCATCTTTGAGCCTCT
GGCATCCTCTCACACCCAGAAATCAGTTGGAGTAAGTTTAATTGGCCCTGCTCCAGCTGGCCTTTGAAGCACAAGTTTAAATCTCCACCT
TCTGTGCACTGACCAGAGTCTAAAATAAAAGTTGTCAGTACCATAAAGGAAAAGGGATCCACACAGGTAGCCTTCTCCTTGGATACAGGT
ACATCTTACTGTAAGAATTTCAAGTCCTGGCTGGGCGCAGTGGCTCACTCCTGTAATCCCAGCACTTTGAGAGACCGAGGCAGGCAGATC
ACTTGAGGTCAGGAATTCAAGACCAACCTGGCCAACATGGTGAAACCCTGTCTCTAATAAAAAAAAAATAGAAAAATCAGCCGGGTGTGG
TGGCACACACCTGTAATCCTAGCTACTCAGGAGGCTGAGGCAAGAGAATCTCTTGAACCTGTGAGCCAGAGGTTGCAGTGAGCCGAGATT
CCACCACTGCACTCCAGCCTGGGCAACAGAGCAAAACTCTGTCTCAAAAAAAAAAAAAAAAAGGCAAAATTAAAGAATTTCAAGTCCCTA
ATTTACTCTAACCAAGCATTTTCAGTCTTACAAAGAAATCTAGTGCACGACACCTTTAAAATGCCTAGATTTCCATTGCCTAAAGTAAGG
TGTGACCAGTGAAACAACAGCAGAGAATCATGTTCCTTTGCTGTGGAACACATAAGCCCCACAGTTTTCCAGTCAGCCTAATACATGGGT
ATCCCCCGACCCCATCTGCCTCCTTAAGCCACAGTCCTTGGTGGGGAACTCTAAGGGGGACGGAGTCAGTACCCCGGACAGGGCCACATT
TGCATGAGACATGGCTGTCTCACAGGTCACAGAGCCATTACAACAGCTTACTAGTTTTTCATGGATTTGTTGGATTAACACCTTAAGCAG
GTTTTTTATTGTTATTTTGTTTGTTTGTTTGTTTTGAGACGGGAGTTTCTCTCTTGTCTCCCAGGCTGGAGTGCAATCGCGCAATCTCGG
CTCACGGTAACCTCTGCCTCCCAGGTTCAAGCGAGTCTCCTGCCTCAGCCTTCTGAGTAGCTGGGATTACAGGCATGCGCCACCACGCCC
AACTAATTTTGTATTTTTAGTAGAGACGGGGTTTCTCCTTGTTGGTCAGGCTGGTCTCAAACCCCGGACCTCAGGTGATCCCCCCACCTT
GGCCTCCCAAAGTGCCAGGATTACAGGCATGAGCCACTGTGTCCGGTCTTGAGCAGGTTTTTAAAATCTCCAGTGGCCATAAAACTAGCC
AGGGTAGCTCATGCTTTTACTGGTTGGAATAAGGAGCCAAAACCAACAAAATAATATTTATTAGGGCTCGATGCCCATTTCTGTGGCTAA
GGCTTAGGTTTGGTGTGCAGAGCCTGGCCTGCTCTTGTGGGCTGTGGTTGCTGTGACAGTTTCGTTTTCTGAATCTTTGTAATGCTCTTC
CACCCTGCTCGTGCTGCCCAGAGGCTGATCTGCAAACCTGGGCAGTATTCCACACTGAAGCTCAGTTTGCAAACCTTCTGCTGTGTTAAT
TCTGGTCAGTTTCACACAGAAGTCACGAGGGCCTCTGCCCAGGACCTTCTATTCACATTTCAAGAATCCCTTTCTGAAATTCTCCAACTC
TCTGGTCAGGAGGAGGAGCACCATTGGGGCGGGGTAGGCAGCTAGAGGCGCAGGAGCGAATCCAGGTTCCTTGCGTGGTTCCCAGCCTCT
GCTGACAGCACCTCAGCTACCAGGTGGGGAGTGGAAATTCAGCCTGCTTAGAGGACTGACCTCTACAGTTCATATTTGCAGTGACATAAA
AGGCAAAGAGGAGCTGGCATGGTGGTACAGAAGGTATCAGTCAAGCGCAGGCTCTTCAGAAACCTAGAAACTAAAAAGAGATGCAACATG
TGACTGGCCATCAGCCAGACATGTCTAGGGTGAGACCAGTGCTCAGCACCACCCGCCAAGGAACACTGATGAGTTGTGGGACATTATGGT
CGGCCAAGTGAGGAATGATTGCAGGGACCAGAGAAGACCAAAGATGCCAGATGTCCCCAGAGTTTCTTGAGGGCTGGGTTTCACGTCTTT
GCTTGTCCTTTTTGTCCCCACTTGCCTGCACCGTGCCTGACTCATCCAGTGGGGAAGGTGACTCAAGAAGTTGTTTAAGCCTAGGCCTAG
GCAGTCCACTTCGGGAGGTGGGGGCACTCCACACTGGGGGGCCCTGCAGCTCCAGGGCTGGTGCTCTAGCAGATCCGCTCAGGCACGGTT
GGGTGACCGTGGGGTCACCGATTGCGTAGATTATTTCTAGGGCAGTGCTGGGTTAGAAATGTCTGTCTGGAAACAGGACACATCTTGCCA
CCACAAGTCCACACCTGGCCTTGGCTGCTGCCCGCTCTCTGCAGCGTGGATTTCCTTTGCCCATTTGGGCCAGAAGGTCACCAGGAGTTC
ATCACTGCTTAGTGTCAACTTGACATCTTCAGCTTCCAGACAGAAAACCCATGCTTTACTTTGTACAGCCCTGTCCCAGAGTTAGTAAGC
CTCGGCTTGTCACCTGCTTGCAAAGGGTATAGACATCATTCTGGGTAGTTCTAGAGGATATCGCAACAAGTGCGTTTGAAGGTTCAGCAC
AGCTGGAATTGTACGGTAGTGAGCTCTTCAAAATGAAAACAGAATGACCGGATGGCCATCTGTCCTGGAAACTGTAGAATTGAATAAATC
ACTGAAAATAGAACACTTCTTGGAGGCTTTCTTCAGAACTGAACTAGAAACAAGGTTTCCAGGCTCCCAGGTCAGTAGACCAAACCAACT
TCCTTAGATTTTTTTTTTTAAGCTGTTTGCAGAAAACTGGGTGGTAGCGTGTCTGAACCAAACGGAAGAATAGCCAGCGGAGCATGGACT
GTTCCAGCACGGGCCAGATGGCCAGCTGTCGAGAGCAGCCCTGCCCAGATTGCGGTGGGGGCTGTGCCAGCGGCTCCGCAGGGCCCTTCC
AACTCTGGAGTGTCTGTAGTTCTTGTGAAACCAAAACGTTGACTACCTGCCTCTTTCCTCGGGCATCGACGTGCTCATTTCCAAAGATGA
TGGTGCAGGTGACCTTTTCCATCGTGAGCTAAGAGAAGGTTAGGAGGCCTGAGGGGCGGGCCTTGTGTCCCCTCCTCCCCCTCCACAGCC
CCTGAGGTGGAGCTTCCCTCACAGACCCCATCTGGTCGAGCCTACGGCTGCCCAGTGTACACTCAGTGATGCTTATACCAAATAGGGCAT
GTGCGCTGGTGTCTGTTGGGGACAGCCCCATCCCTACCTTGGAGTCGGCAGAGAAGCAGCAATAAGCATTAGGCGAATGATTGAAAGGGC
TGCTGCGCCAAGAGGCCTTCAGTCCCCTTAACGTGGCTTTCCAACTTCCTGACGAGGCTACAAAGGCTCCGCTCACAAAAGAAAGCCAAT
AATGTAAATAAATAGAAAACGAAGCCTCCACGCGTGGTTTTTAAAGGGGGATGATGAATGTGACACCACCCACAGAATGCATTAGAATCT
GGTTTTTCTGTGCTTTGTCATTTTACTCTGATAGGAATTTTTGTTACCTAACTCTGTGCATAACTTATTTAATGTACTGTATAAATGAAC

>78645_78645_4_RUNX1-CBFA2T2_RUNX1_chr21_36231771_ENST00000325074_CBFA2T2_chr20_32194762_ENST00000375279_length(amino acids)=776AA_BP=193
MPAAPRGPAQGEAAARTRSRDASTSRRFTPPSTALSPGKMSEALPLGAPDAGAALAGKLRSGDRSMVEVLADHPGELVRTDSPNFLCSVL
PTHWRCNKTLPIAFKVVALGDVPDGTLVTVMAGNDENYSAELRNATAAMKNQVARFNDLRFVGRSGRGKSFTLTITVFTNPPQVATYHRA
IKITVDGPREPRIGPEKRVPAMPGSPVEVKIQSRSSPPTMPPLPPINPGGPRPVSFTPTALSNGINHSPPTLNGAPSPPQRFSNGPASST
SSALTNQQLPATCGARQLSKLKRFLTTLQQFGNDISPEIGEKVRTLVLALVNSTVTIEEFHCKLQEATNFPLRPFVIPFLKANLPLLQRE
LLHCARAAKQTPSQYLAQHEHLLLNTSIASPADSSELLMEVHGNGKRPSPERREENSFDRDTIAPEPPAKRVCTISPAPRHSPALTVPLM
NPGGQFHPTPPPLQHYTLEDIATSHLYREPNKMLEHREVRDRHHSLGLNGGYQDELVDHRLTEREWADEWKHLDHALNCIMEMVEKTRRS
MAVLRRCQESDREELNYWKRRYNENTELRKTGTELVSRQHSPGSADSLSNDSQREFNSRPGTGYVPVEFWKKTEEAVNKVKIQAMSEVQK
AVAEAEQKAFEVIATERARMEQTIADVKRQAAEDAFLVINEQEESTENCWNCGRKASETCSGCNIARYCGSFCQHKDWERHHRLCGQNLH

--------------------------------------------------------------
>78645_78645_5_RUNX1-CBFA2T2_RUNX1_chr21_36231771_ENST00000344691_CBFA2T2_chr20_32194762_ENST00000342704_length(transcript)=4759nt_BP=2110nt
CATAGAGCCAGCGGGCGCGGGCGGGACGGGCGCCCCGCGGCCGGACCCAGCCAGGGCACCACGCTGCCCGGCCCTGCGCCGCCAGGCACT
TCTTTCCGGGGCTCCTAGGGACGCCAGAAGGAAGTCAACCTCTGCTGCTTCTCCTTGGCCTGCGTTGGACCTTCCTTTTTTTGTTGTTTT
TTTTTGTTTTTCCCCTTTCTTCCTTTTGAATTAACTGGCTTCTTGGCTGGATGTTTTCAACTTCTTTCCTGGCTGCGAACTTTTCCCCAA
TTGTTTTCCTTTTACAACAGGGGGAGAAAGTGCTCTGTGGTCCGAGGCGAGCCGTGAAGTTGCGTGTGCGTGGCAGTGTGCGTGGCAGGA
TGTGCGTGCGTGTGTAACCCGAGCCGCCCGATCTGTTTCGATCTGCGCCGCGGAGCCCTCCCTCAAGGCCCGCTCCACCTGCTGCGGTTA
CGCGGCGCTCGTGGGTGTTCGTGCCTCGGAGCAGCTAACCGGCGGGTGCTGGGCGACGGTGGAGGAGTATCGTCTCGCTGCTGCCCGAGT
CAGGGCTGAGTCACCCAGCTGATGTAGACAGTGGCTGCCTTCCGAAGAGTGCGTGTTTGCATGTGTGTGACTCTGCGGCTGCTCAACTCC
CAACAAACCAGAGGACCAGCCACAAACTTAACCAACATCCCCAAACCCGAGTTCACAGATGTGGGAGAGCTGTAGAACCCTGAGTGTCAT
CGACTGGGCCTTCTTATGATTGTTGTTTTAAGATTAGCTGAAGATCTCTGAAACGCTGAATTTTCTGCACTGAGCGTTTTGACAGAATTC
ATTGAGAGAACAGAGAACATGACAAGTACTTCTAGCTCAGCACTGCTCCAACTACTGAAGCTGATTTTCAAGGCTACTTAAAAAAATCTG
CAGCGTACATTAATGGATTTCTGTTGTGTTTAAATTCTCCACAGATTGTATTGTAAATATTTTATGAAGTAGAGCATATGTATATATTTA
TATATACGTGCACATACATTAGTAGCACTACCTTTGGAAGTCTCAGCTCTTGCTTTTCGGGACTGAAGCCAGTTTTGCATGATAAAAGTG
GCCTTGTTACGGGAGATAATTGTGTTCTGTTGGGACTTTAGACAAAACTCACCTGCAAAAAACTGACAGGCATTAACTACTGGAACTTCC
AAATAATGTGTTTGCTGATCGTTTTACTCTTCGCATAAATATTTTAGGAAGTGTATGAGAATTTTGCCTTCAGGAACTTTTCTAACAGCC
AAAGACAGAACTTAACCTCTGCAAGCAAGATTCGTGGAAGATAGTCTCCACTTTTTAATGCACTAAGCAATCGGTTGCTAGGAGCCCATC
CTGGGTCAGAGGCCGATCCGCAGAACCAGAACGTTTTCCCCTCCTGGACTGTTAGTAACTTAGTCTCCCTCCTCCCCTAACCACCCCCGC
CCCCCCCCACCCCCCGCAGTAATAAAGGCCCCTGAACGTGTATGTTGGTCTCCCGGGAGCTGCTTGCTGAAGATCCGCGCCCCTGTCGCC
GTCTGGTAGGAGCTGTTTGCAGGGTCCTAACTCAATCGGCTTGTTGTGATGCGTATCCCCGTAGATGCCAGCACGAGCCGCCGCTTCACG
CCGCCTTCCACCGCGCTGAGCCCAGGCAAGATGAGCGAGGCGTTGCCGCTGGGCGCCCCGGACGCCGGCGCTGCCCTGGCCGGCAAGCTG
AGGAGCGGCGACCGCAGCATGGTGGAGGTGCTGGCCGACCACCCGGGCGAGCTGGTGCGCACCGACAGCCCCAACTTCCTCTGCTCCGTG
CTGCCTACGCACTGGCGCTGCAACAAGACCCTGCCCATCGCTTTCAAGGTGGTGGCCCTAGGGGATGTTCCAGATGGCACTCTGGTCACT
GTGATGGCTGGCAATGATGAAAACTACTCGGCTGAGCTGAGAAATGCTACCGCAGCCATGAAGAACCAGGTTGCAAGATTTAATGACCTC
AGGTTTGTCGGTCGAAGTGGAAGAGGGAAAAGCTTCACTCTGACCATCACTGTCTTCACAAACCCACCGCAAGTCGCCACCTACCACAGA
GCCATCAAAATCACAGTGGATGGGCCCCGAGAACCTCGAATTGGTCCTGAGAAAAGGGTGCCAGCGATGCCTGGATCGCCTGTGGAAGTG
AAGATACAGTCCAGATCCTCACCTCCCACCATGCCACCCCTCCCACCAATAAATCCTGGAGGACCGAGGCCAGTGTCCTTCACTCCTACT
GCATTAAGCAATGGCATCAACCATTCTCCTCCTACCCTGAATGGTGCCCCATCACCGCCACAGAGATTCAGCAATGGTCCTGCCTCCTCC
ACATCATCTGCACTCACAAATCAGCAATTGCCAGCCACTTGTGGTGCTCGACAACTCAGCAAGTTGAAACGCTTTCTTACCACTCTGCAA
CAGTTTGGCAATGACATCTCCCCTGAGATTGGGGAGAAGGTGCGGACTCTTGTTCTTGCACTGGTGAACTCAACAGTGACAATTGAGGAA
TTCCACTGTAAGCTCCAAGAAGCCACAAACTTTCCCCTTCGTCCTTTTGTGATTCCATTTCTCAAGGCCAACCTGCCCCTGCTGCAGCGG
GAACTGCTGCACTGCGCTCGGGCGGCCAAGCAGACCCCATCCCAGTACCTGGCTCAGCACGAACACCTTCTGCTCAACACAAGCATTGCA
TCGCCTGCTGACTCGTCAGAGTTGCTCATGGAGGTGCACGGAAATGGGAAGAGGCCCAGTCCAGAGAGGAGAGAAGAGAATAGTTTTGAT
AGAGACACAATTGCTCCTGAGCCTCCTGCCAAGAGAGTATGTACCATCAGCCCTGCTCCTCGGCACAGTCCTGCTCTCACTGTGCCCCTC
ATGAATCCCGGGGGCCAATTCCATCCTACCCCTCCACCTCTTCAGCATTACACCTTAGAGGATATTGCAACTTCTCACCTGTATCGGGAA
CCCAACAAGATGCTAGAGCATCGAGAAGTTCGTGATAGACACCACAGTCTTGGTCTAAATGGAGGCTATCAAGATGAGTTGGTAGATCAT
CGTTTGACAGAAAGGGAATGGGCTGATGAATGGAAACATCTTGACCATGCGCTGAATTGCATTATGGAAATGGTAGAGAAAACAAGGCGC
TCTATGGCAGTTCTGCGGCGCTGTCAGGAATCAGATCGTGAAGAACTCAACTACTGGAAAAGACGGTACAATGAAAACACAGAGCTGAGG
AAAACGGGGACCGAGTTGGTCTCCAGGCAGCACAGCCCTGGGAGTGCAGATTCTCTCAGCAATGATTCTCAGAGAGAGTTCAACAGCAGG
CCAGGTACAGGATACGTACCTGTGGAGTTTTGGAAAAAAACAGAAGAAGCTGTGAATAAGGTGAAAATTCAGGCCATGTCAGAAGTACAG
AAGGCCGTCGCTGAGGCAGAGCAGAAAGCCTTTGAAGTGATTGCAACAGAGAGAGCACGAATGGAGCAAACCATAGCGGATGTCAAGCGG
CAGGCCGCAGAGGATGCTTTCCTCGTCATCAATGAGCAAGAGGAGTCCACGGAGAACTGCTGGAACTGTGGCCGCAAAGCCAGCGAGACA
TGCAGTGGCTGCAATATCGCGCGATACTGTGGCTCTTTCTGCCAGCACAAGGACTGGGAGCGGCACCACCGCCTCTGTGGTCAGAACCTG
CATGGCCAGAGCCCCCACGGCCAGGGCCGGCCGCTGCTTCCTGTAGGCAGGGGCTCCTCTGCCAGGTCCGCCGACTGCAGCGTGCCCAGC
CCAGCCCTCGACAAGACCTCGGCAACCACATCGCGTTCCTCAACACCTGCTTCTGTGACAGCTATCGACACCAACGGACTCTGAGCCCCG
GACTCTGCTTACCCTGATGGCTGCTCAGCACCACAGAGTGCTTGGGCTGAGGGACTGACTGTTGGAACCCGTGCATGTAGCTGCCGGGTC
ATCAGCAAGAAATGAATTGGAGGCAGGAAGAGTCCAAGCCTGAATAATAACACCCCACAGCCTCTCTGTGCACTTGCTGTCTGCGGAGCC
AGTGTGCCATTCTCTGCACATGGGCAGCCAGCCTGAGCTGCCTCCTCCATGGCTTTCCTGGTTTGTTCCTCTCTCCACTGAAGCTGACTT
AGCCGGCCCCTTTTCAGTGTAGACCACCAGCTCCCCTCCCCATCTCCTTGAGTCAGCAGACTGTCCAATGTGCTCAGCCAGGCTGGAGGC
GGCAGGCGGCAGGCAGCAGGCTGTGGAGGAGGCCCCTCGGTCAGGGAGCGGCCTGCCTCACCCCTGAATAGCTCCTTCGGCCCCATCTCC
ATCCTCAGCAGATGACACTGATTGGCCTCACGGGGACTTGGGTAAGCAACAGGCGGCATTCAGGACTCTTCTCAACCCTGCTGTTCAGAC
TTGATAAGATCTCAGAGTCCACAGGAAAGAAGTCACTGTTGCAATAAAAGCACCCGTAGTAGCAAAAACATAAAACAAATAAAACTTCCC
CCACATCACAGATGATTTTGGACAAGATTTTCCAACCTTGCTGGCTACTTTAGTTTGGGACCTGTTTTTTTTCTCATTTGATTTTGCTTG
TGCAGAAAATAGTTTCCAGCACATGGATTGATCTGAGAGAGAATGAGGCTCAGTTGTGGATAGTCTGTTTTCTCTGAGCATGTTGGCCAA

>78645_78645_5_RUNX1-CBFA2T2_RUNX1_chr21_36231771_ENST00000344691_CBFA2T2_chr20_32194762_ENST00000342704_length(amino acids)=761AA_BP=178
MRIPVDASTSRRFTPPSTALSPGKMSEALPLGAPDAGAALAGKLRSGDRSMVEVLADHPGELVRTDSPNFLCSVLPTHWRCNKTLPIAFK
VVALGDVPDGTLVTVMAGNDENYSAELRNATAAMKNQVARFNDLRFVGRSGRGKSFTLTITVFTNPPQVATYHRAIKITVDGPREPRIGP
EKRVPAMPGSPVEVKIQSRSSPPTMPPLPPINPGGPRPVSFTPTALSNGINHSPPTLNGAPSPPQRFSNGPASSTSSALTNQQLPATCGA
RQLSKLKRFLTTLQQFGNDISPEIGEKVRTLVLALVNSTVTIEEFHCKLQEATNFPLRPFVIPFLKANLPLLQRELLHCARAAKQTPSQY
LAQHEHLLLNTSIASPADSSELLMEVHGNGKRPSPERREENSFDRDTIAPEPPAKRVCTISPAPRHSPALTVPLMNPGGQFHPTPPPLQH
YTLEDIATSHLYREPNKMLEHREVRDRHHSLGLNGGYQDELVDHRLTEREWADEWKHLDHALNCIMEMVEKTRRSMAVLRRCQESDREEL
NYWKRRYNENTELRKTGTELVSRQHSPGSADSLSNDSQREFNSRPGTGYVPVEFWKKTEEAVNKVKIQAMSEVQKAVAEAEQKAFEVIAT
ERARMEQTIADVKRQAAEDAFLVINEQEESTENCWNCGRKASETCSGCNIARYCGSFCQHKDWERHHRLCGQNLHGQSPHGQGRPLLPVG

--------------------------------------------------------------
>78645_78645_6_RUNX1-CBFA2T2_RUNX1_chr21_36231771_ENST00000344691_CBFA2T2_chr20_32194762_ENST00000375279_length(transcript)=9254nt_BP=2110nt
CATAGAGCCAGCGGGCGCGGGCGGGACGGGCGCCCCGCGGCCGGACCCAGCCAGGGCACCACGCTGCCCGGCCCTGCGCCGCCAGGCACT
TCTTTCCGGGGCTCCTAGGGACGCCAGAAGGAAGTCAACCTCTGCTGCTTCTCCTTGGCCTGCGTTGGACCTTCCTTTTTTTGTTGTTTT
TTTTTGTTTTTCCCCTTTCTTCCTTTTGAATTAACTGGCTTCTTGGCTGGATGTTTTCAACTTCTTTCCTGGCTGCGAACTTTTCCCCAA
TTGTTTTCCTTTTACAACAGGGGGAGAAAGTGCTCTGTGGTCCGAGGCGAGCCGTGAAGTTGCGTGTGCGTGGCAGTGTGCGTGGCAGGA
TGTGCGTGCGTGTGTAACCCGAGCCGCCCGATCTGTTTCGATCTGCGCCGCGGAGCCCTCCCTCAAGGCCCGCTCCACCTGCTGCGGTTA
CGCGGCGCTCGTGGGTGTTCGTGCCTCGGAGCAGCTAACCGGCGGGTGCTGGGCGACGGTGGAGGAGTATCGTCTCGCTGCTGCCCGAGT
CAGGGCTGAGTCACCCAGCTGATGTAGACAGTGGCTGCCTTCCGAAGAGTGCGTGTTTGCATGTGTGTGACTCTGCGGCTGCTCAACTCC
CAACAAACCAGAGGACCAGCCACAAACTTAACCAACATCCCCAAACCCGAGTTCACAGATGTGGGAGAGCTGTAGAACCCTGAGTGTCAT
CGACTGGGCCTTCTTATGATTGTTGTTTTAAGATTAGCTGAAGATCTCTGAAACGCTGAATTTTCTGCACTGAGCGTTTTGACAGAATTC
ATTGAGAGAACAGAGAACATGACAAGTACTTCTAGCTCAGCACTGCTCCAACTACTGAAGCTGATTTTCAAGGCTACTTAAAAAAATCTG
CAGCGTACATTAATGGATTTCTGTTGTGTTTAAATTCTCCACAGATTGTATTGTAAATATTTTATGAAGTAGAGCATATGTATATATTTA
TATATACGTGCACATACATTAGTAGCACTACCTTTGGAAGTCTCAGCTCTTGCTTTTCGGGACTGAAGCCAGTTTTGCATGATAAAAGTG
GCCTTGTTACGGGAGATAATTGTGTTCTGTTGGGACTTTAGACAAAACTCACCTGCAAAAAACTGACAGGCATTAACTACTGGAACTTCC
AAATAATGTGTTTGCTGATCGTTTTACTCTTCGCATAAATATTTTAGGAAGTGTATGAGAATTTTGCCTTCAGGAACTTTTCTAACAGCC
AAAGACAGAACTTAACCTCTGCAAGCAAGATTCGTGGAAGATAGTCTCCACTTTTTAATGCACTAAGCAATCGGTTGCTAGGAGCCCATC
CTGGGTCAGAGGCCGATCCGCAGAACCAGAACGTTTTCCCCTCCTGGACTGTTAGTAACTTAGTCTCCCTCCTCCCCTAACCACCCCCGC
CCCCCCCCACCCCCCGCAGTAATAAAGGCCCCTGAACGTGTATGTTGGTCTCCCGGGAGCTGCTTGCTGAAGATCCGCGCCCCTGTCGCC
GTCTGGTAGGAGCTGTTTGCAGGGTCCTAACTCAATCGGCTTGTTGTGATGCGTATCCCCGTAGATGCCAGCACGAGCCGCCGCTTCACG
CCGCCTTCCACCGCGCTGAGCCCAGGCAAGATGAGCGAGGCGTTGCCGCTGGGCGCCCCGGACGCCGGCGCTGCCCTGGCCGGCAAGCTG
AGGAGCGGCGACCGCAGCATGGTGGAGGTGCTGGCCGACCACCCGGGCGAGCTGGTGCGCACCGACAGCCCCAACTTCCTCTGCTCCGTG
CTGCCTACGCACTGGCGCTGCAACAAGACCCTGCCCATCGCTTTCAAGGTGGTGGCCCTAGGGGATGTTCCAGATGGCACTCTGGTCACT
GTGATGGCTGGCAATGATGAAAACTACTCGGCTGAGCTGAGAAATGCTACCGCAGCCATGAAGAACCAGGTTGCAAGATTTAATGACCTC
AGGTTTGTCGGTCGAAGTGGAAGAGGGAAAAGCTTCACTCTGACCATCACTGTCTTCACAAACCCACCGCAAGTCGCCACCTACCACAGA
GCCATCAAAATCACAGTGGATGGGCCCCGAGAACCTCGAATTGGTCCTGAGAAAAGGGTGCCAGCGATGCCTGGATCGCCTGTGGAAGTG
AAGATACAGTCCAGATCCTCACCTCCCACCATGCCACCCCTCCCACCAATAAATCCTGGAGGACCGAGGCCAGTGTCCTTCACTCCTACT
GCATTAAGCAATGGCATCAACCATTCTCCTCCTACCCTGAATGGTGCCCCATCACCGCCACAGAGATTCAGCAATGGTCCTGCCTCCTCC
ACATCATCTGCACTCACAAATCAGCAATTGCCAGCCACTTGTGGTGCTCGACAACTCAGCAAGTTGAAACGCTTTCTTACCACTCTGCAA
CAGTTTGGCAATGACATCTCCCCTGAGATTGGGGAGAAGGTGCGGACTCTTGTTCTTGCACTGGTGAACTCAACAGTGACAATTGAGGAA
TTCCACTGTAAGCTCCAAGAAGCCACAAACTTTCCCCTTCGTCCTTTTGTGATTCCATTTCTCAAGGCCAACCTGCCCCTGCTGCAGCGG
GAACTGCTGCACTGCGCTCGGGCGGCCAAGCAGACCCCATCCCAGTACCTGGCTCAGCACGAACACCTTCTGCTCAACACAAGCATTGCA
TCGCCTGCTGACTCGTCAGAGTTGCTCATGGAGGTGCACGGAAATGGGAAGAGGCCCAGTCCAGAGAGGAGAGAAGAGAATAGTTTTGAT
AGAGACACAATTGCTCCTGAGCCTCCTGCCAAGAGAGTATGTACCATCAGCCCTGCTCCTCGGCACAGTCCTGCTCTCACTGTGCCCCTC
ATGAATCCCGGGGGCCAATTCCATCCTACCCCTCCACCTCTTCAGCATTACACCTTAGAGGATATTGCAACTTCTCACCTGTATCGGGAA
CCCAACAAGATGCTAGAGCATCGAGAAGTTCGTGATAGACACCACAGTCTTGGTCTAAATGGAGGCTATCAAGATGAGTTGGTAGATCAT
CGTTTGACAGAAAGGGAATGGGCTGATGAATGGAAACATCTTGACCATGCGCTGAATTGCATTATGGAAATGGTAGAGAAAACAAGGCGC
TCTATGGCAGTTCTGCGGCGCTGTCAGGAATCAGATCGTGAAGAACTCAACTACTGGAAAAGACGGTACAATGAAAACACAGAGCTGAGG
AAAACGGGGACCGAGTTGGTCTCCAGGCAGCACAGCCCTGGGAGTGCAGATTCTCTCAGCAATGATTCTCAGAGAGAGTTCAACAGCAGG
CCAGGTACAGGATACGTACCTGTGGAGTTTTGGAAAAAAACAGAAGAAGCTGTGAATAAGGTGAAAATTCAGGCCATGTCAGAAGTACAG
AAGGCCGTCGCTGAGGCAGAGCAGAAAGCCTTTGAAGTGATTGCAACAGAGAGAGCACGAATGGAGCAAACCATAGCGGATGTCAAGCGG
CAGGCCGCAGAGGATGCTTTCCTCGTCATCAATGAGCAAGAGGAGTCCACGGAGAACTGCTGGAACTGTGGCCGCAAAGCCAGCGAGACA
TGCAGTGGCTGCAATATCGCGCGATACTGTGGCTCTTTCTGCCAGCACAAGGACTGGGAGCGGCACCACCGCCTCTGTGGTCAGAACCTG
CATGGCCAGAGCCCCCACGGCCAGGGCCGGCCGCTGCTTCCTGTAGGCAGGGGCTCCTCTGCCAGGTCCGCCGACTGCAGCGTGCCCAGC
CCAGCCCTCGACAAGACCTCGGCAACCACATCGCGTTCCTCAACACCTGCTTCTGTGACAGCTATCGACACCAACGGACTCTGAGCCCCG
GACTCTGCTTACCCTGATGGCTGCTCAGCACCACAGAGTGCTTGGGCTGAGGGACTGACTGTTGGAACCCGTGCATGTAGCTGCCGGGTC
ATCAGCAAGAAATGAATTGGAGGCAGGAAGAGTCCAAGCCTGAATAATAACACCCCACAGCCTCTCTGTGCACTTGCTGTCTGCGGAGCC
AGTGTGCCATTCTCTGCACATGGGCAGCCAGCCTGAGCTGCCTCCTCCATGGCTTTCCTGGTTTGTTCCTCTCTCCACTGAAGCTGACTT
AGCCGGCCCCTTTTCAGTGTAGACCACCAGCTCCCCTCCCCATCTCCTTGAGTCAGCAGACTGTCCAATGTGCTCAGCCAGGCTGGAGGC
GGCAGGCGGCAGGCAGCAGGCTGTGGAGGAGGCCCCTCGGTCAGGGAGCGGCCTGCCTCACCCCTGAATAGCTCCTTCGGCCCCATCTCC
ATCCTCAGCAGATGACACTGATTGGCCTCACGGGGACTTGGGTAAGCAACAGGCGGCATTCAGGACTCTTCTCAACCCTGCTGTTCAGAC
TTGATAAGATCTCAGAGTCCACAGGAAAGAAGTCACTGTTGCAATAAAAGCACCCGTAGTAGCAAAAACATAAAACAAATAAAACTTCCC
CCACATCACAGATGATTTTGGACAAGATTTTCCAACCTTGCTGGCTACTTTAGTTTGGGACCTGTTTTTTTTCTCATTTGATTTTGCTTG
TGCAGAAAATAGTTTCCAGCACATGGATTGATCTGAGAGAGAATGAGGCTCAGTTGTGGATAGTCTGTTTTCTCTGAGCATGTTGGCCAA
CTAGTATCGTCAAATTATTGAGTGGATCATCTCTTGGAAATGCAGAACTTCTGCCACCACTTGGCTATTTGCACAGTCATCTTGTTCTGT
GTCCTTTTATCTCTCAGACCACACACATCTGGAACGCTGTGGGCATCTTCTGCCCATGGGCTCCATTTGGCACCTGCTGAGCCACAGTTG
TCCTGCTGGATGTGCTGTGCAGGTTGGTAGGACTTGCCCCCACTGTCAAGGCCTGGTCTCATCTGAAAAGCCCTCCTGGACCTCAAAGAA
TTCTTCAGACCTCATAGTTACAGGTCATTATATCTACTATGTTGATTTATCATCAGGCACACAACTTCTGTTTCCTTCTCTTGTGTTATC
TGATAGCGTCCCTCCTTGAGCTCATCAGAAAGGTTTTATGAAATGTGAACCATTTTGGGAAAAGCTGATCAATTTTTCTTCCTAGCTTCC
CATTTTCAAATGGGACATCACTCATATCCCTTTCAGAATGTTAGGAACTGCCTCCCACATTCTTCCCTGTCTTTTTGGGTTTTGTTTTTT
GTTGTTGTGGTGGTTTTTTAACACAAAGTCTCACTCTGTTGCCCAGGCTGGAGTGCAGTGGCATGATCTTGGCTCACTGCAACCTCTGCC
TTCCAGGTTCAAGCAATTCTCCTGCCTCAGCCTCCCGAGTAGCTGAGATTACAGGCGCCCACCACCACGCCCAGCTAATTTTTGTATTTT
TAGTAGAGACAGGGTTTCACCATGTTGGCCAGGCTGATCTCGAACTCCTGACCTCAGGTGACCTGCCTTGGCCTCCCAAAGTGCAGGGAT
TACAAGCGTGAGCCACCATGCCCGGCCTGTCTTTTTGGTTTTGATGGGAGTCTGAGGACCCCGACCCCTCCTGCTCTCCATCTTTGAGCC
TCTGGCATCCTCTCACACCCAGAAATCAGTTGGAGTAAGTTTAATTGGCCCTGCTCCAGCTGGCCTTTGAAGCACAAGTTTAAATCTCCA
CCTTCTGTGCACTGACCAGAGTCTAAAATAAAAGTTGTCAGTACCATAAAGGAAAAGGGATCCACACAGGTAGCCTTCTCCTTGGATACA
GGTACATCTTACTGTAAGAATTTCAAGTCCTGGCTGGGCGCAGTGGCTCACTCCTGTAATCCCAGCACTTTGAGAGACCGAGGCAGGCAG
ATCACTTGAGGTCAGGAATTCAAGACCAACCTGGCCAACATGGTGAAACCCTGTCTCTAATAAAAAAAAAATAGAAAAATCAGCCGGGTG
TGGTGGCACACACCTGTAATCCTAGCTACTCAGGAGGCTGAGGCAAGAGAATCTCTTGAACCTGTGAGCCAGAGGTTGCAGTGAGCCGAG
ATTCCACCACTGCACTCCAGCCTGGGCAACAGAGCAAAACTCTGTCTCAAAAAAAAAAAAAAAAAGGCAAAATTAAAGAATTTCAAGTCC
CTAATTTACTCTAACCAAGCATTTTCAGTCTTACAAAGAAATCTAGTGCACGACACCTTTAAAATGCCTAGATTTCCATTGCCTAAAGTA
AGGTGTGACCAGTGAAACAACAGCAGAGAATCATGTTCCTTTGCTGTGGAACACATAAGCCCCACAGTTTTCCAGTCAGCCTAATACATG
GGTATCCCCCGACCCCATCTGCCTCCTTAAGCCACAGTCCTTGGTGGGGAACTCTAAGGGGGACGGAGTCAGTACCCCGGACAGGGCCAC
ATTTGCATGAGACATGGCTGTCTCACAGGTCACAGAGCCATTACAACAGCTTACTAGTTTTTCATGGATTTGTTGGATTAACACCTTAAG
CAGGTTTTTTATTGTTATTTTGTTTGTTTGTTTGTTTTGAGACGGGAGTTTCTCTCTTGTCTCCCAGGCTGGAGTGCAATCGCGCAATCT
CGGCTCACGGTAACCTCTGCCTCCCAGGTTCAAGCGAGTCTCCTGCCTCAGCCTTCTGAGTAGCTGGGATTACAGGCATGCGCCACCACG
CCCAACTAATTTTGTATTTTTAGTAGAGACGGGGTTTCTCCTTGTTGGTCAGGCTGGTCTCAAACCCCGGACCTCAGGTGATCCCCCCAC
CTTGGCCTCCCAAAGTGCCAGGATTACAGGCATGAGCCACTGTGTCCGGTCTTGAGCAGGTTTTTAAAATCTCCAGTGGCCATAAAACTA
GCCAGGGTAGCTCATGCTTTTACTGGTTGGAATAAGGAGCCAAAACCAACAAAATAATATTTATTAGGGCTCGATGCCCATTTCTGTGGC
TAAGGCTTAGGTTTGGTGTGCAGAGCCTGGCCTGCTCTTGTGGGCTGTGGTTGCTGTGACAGTTTCGTTTTCTGAATCTTTGTAATGCTC
TTCCACCCTGCTCGTGCTGCCCAGAGGCTGATCTGCAAACCTGGGCAGTATTCCACACTGAAGCTCAGTTTGCAAACCTTCTGCTGTGTT
AATTCTGGTCAGTTTCACACAGAAGTCACGAGGGCCTCTGCCCAGGACCTTCTATTCACATTTCAAGAATCCCTTTCTGAAATTCTCCAA
CTCTCTGGTCAGGAGGAGGAGCACCATTGGGGCGGGGTAGGCAGCTAGAGGCGCAGGAGCGAATCCAGGTTCCTTGCGTGGTTCCCAGCC
TCTGCTGACAGCACCTCAGCTACCAGGTGGGGAGTGGAAATTCAGCCTGCTTAGAGGACTGACCTCTACAGTTCATATTTGCAGTGACAT
AAAAGGCAAAGAGGAGCTGGCATGGTGGTACAGAAGGTATCAGTCAAGCGCAGGCTCTTCAGAAACCTAGAAACTAAAAAGAGATGCAAC
ATGTGACTGGCCATCAGCCAGACATGTCTAGGGTGAGACCAGTGCTCAGCACCACCCGCCAAGGAACACTGATGAGTTGTGGGACATTAT
GGTCGGCCAAGTGAGGAATGATTGCAGGGACCAGAGAAGACCAAAGATGCCAGATGTCCCCAGAGTTTCTTGAGGGCTGGGTTTCACGTC
TTTGCTTGTCCTTTTTGTCCCCACTTGCCTGCACCGTGCCTGACTCATCCAGTGGGGAAGGTGACTCAAGAAGTTGTTTAAGCCTAGGCC
TAGGCAGTCCACTTCGGGAGGTGGGGGCACTCCACACTGGGGGGCCCTGCAGCTCCAGGGCTGGTGCTCTAGCAGATCCGCTCAGGCACG
GTTGGGTGACCGTGGGGTCACCGATTGCGTAGATTATTTCTAGGGCAGTGCTGGGTTAGAAATGTCTGTCTGGAAACAGGACACATCTTG
CCACCACAAGTCCACACCTGGCCTTGGCTGCTGCCCGCTCTCTGCAGCGTGGATTTCCTTTGCCCATTTGGGCCAGAAGGTCACCAGGAG
TTCATCACTGCTTAGTGTCAACTTGACATCTTCAGCTTCCAGACAGAAAACCCATGCTTTACTTTGTACAGCCCTGTCCCAGAGTTAGTA
AGCCTCGGCTTGTCACCTGCTTGCAAAGGGTATAGACATCATTCTGGGTAGTTCTAGAGGATATCGCAACAAGTGCGTTTGAAGGTTCAG
CACAGCTGGAATTGTACGGTAGTGAGCTCTTCAAAATGAAAACAGAATGACCGGATGGCCATCTGTCCTGGAAACTGTAGAATTGAATAA
ATCACTGAAAATAGAACACTTCTTGGAGGCTTTCTTCAGAACTGAACTAGAAACAAGGTTTCCAGGCTCCCAGGTCAGTAGACCAAACCA
ACTTCCTTAGATTTTTTTTTTTAAGCTGTTTGCAGAAAACTGGGTGGTAGCGTGTCTGAACCAAACGGAAGAATAGCCAGCGGAGCATGG
ACTGTTCCAGCACGGGCCAGATGGCCAGCTGTCGAGAGCAGCCCTGCCCAGATTGCGGTGGGGGCTGTGCCAGCGGCTCCGCAGGGCCCT
TCCAACTCTGGAGTGTCTGTAGTTCTTGTGAAACCAAAACGTTGACTACCTGCCTCTTTCCTCGGGCATCGACGTGCTCATTTCCAAAGA
TGATGGTGCAGGTGACCTTTTCCATCGTGAGCTAAGAGAAGGTTAGGAGGCCTGAGGGGCGGGCCTTGTGTCCCCTCCTCCCCCTCCACA
GCCCCTGAGGTGGAGCTTCCCTCACAGACCCCATCTGGTCGAGCCTACGGCTGCCCAGTGTACACTCAGTGATGCTTATACCAAATAGGG
CATGTGCGCTGGTGTCTGTTGGGGACAGCCCCATCCCTACCTTGGAGTCGGCAGAGAAGCAGCAATAAGCATTAGGCGAATGATTGAAAG
GGCTGCTGCGCCAAGAGGCCTTCAGTCCCCTTAACGTGGCTTTCCAACTTCCTGACGAGGCTACAAAGGCTCCGCTCACAAAAGAAAGCC
AATAATGTAAATAAATAGAAAACGAAGCCTCCACGCGTGGTTTTTAAAGGGGGATGATGAATGTGACACCACCCACAGAATGCATTAGAA
TCTGGTTTTTCTGTGCTTTGTCATTTTACTCTGATAGGAATTTTTGTTACCTAACTCTGTGCATAACTTATTTAATGTACTGTATAAATG

>78645_78645_6_RUNX1-CBFA2T2_RUNX1_chr21_36231771_ENST00000344691_CBFA2T2_chr20_32194762_ENST00000375279_length(amino acids)=761AA_BP=178
MRIPVDASTSRRFTPPSTALSPGKMSEALPLGAPDAGAALAGKLRSGDRSMVEVLADHPGELVRTDSPNFLCSVLPTHWRCNKTLPIAFK
VVALGDVPDGTLVTVMAGNDENYSAELRNATAAMKNQVARFNDLRFVGRSGRGKSFTLTITVFTNPPQVATYHRAIKITVDGPREPRIGP
EKRVPAMPGSPVEVKIQSRSSPPTMPPLPPINPGGPRPVSFTPTALSNGINHSPPTLNGAPSPPQRFSNGPASSTSSALTNQQLPATCGA
RQLSKLKRFLTTLQQFGNDISPEIGEKVRTLVLALVNSTVTIEEFHCKLQEATNFPLRPFVIPFLKANLPLLQRELLHCARAAKQTPSQY
LAQHEHLLLNTSIASPADSSELLMEVHGNGKRPSPERREENSFDRDTIAPEPPAKRVCTISPAPRHSPALTVPLMNPGGQFHPTPPPLQH
YTLEDIATSHLYREPNKMLEHREVRDRHHSLGLNGGYQDELVDHRLTEREWADEWKHLDHALNCIMEMVEKTRRSMAVLRRCQESDREEL
NYWKRRYNENTELRKTGTELVSRQHSPGSADSLSNDSQREFNSRPGTGYVPVEFWKKTEEAVNKVKIQAMSEVQKAVAEAEQKAFEVIAT
ERARMEQTIADVKRQAAEDAFLVINEQEESTENCWNCGRKASETCSGCNIARYCGSFCQHKDWERHHRLCGQNLHGQSPHGQGRPLLPVG

--------------------------------------------------------------
>78645_78645_7_RUNX1-CBFA2T2_RUNX1_chr21_36231771_ENST00000358356_CBFA2T2_chr20_32194762_ENST00000342704_length(transcript)=4759nt_BP=2110nt
CATAGAGCCAGCGGGCGCGGGCGGGACGGGCGCCCCGCGGCCGGACCCAGCCAGGGCACCACGCTGCCCGGCCCTGCGCCGCCAGGCACT
TCTTTCCGGGGCTCCTAGGGACGCCAGAAGGAAGTCAACCTCTGCTGCTTCTCCTTGGCCTGCGTTGGACCTTCCTTTTTTTGTTGTTTT
TTTTTGTTTTTCCCCTTTCTTCCTTTTGAATTAACTGGCTTCTTGGCTGGATGTTTTCAACTTCTTTCCTGGCTGCGAACTTTTCCCCAA
TTGTTTTCCTTTTACAACAGGGGGAGAAAGTGCTCTGTGGTCCGAGGCGAGCCGTGAAGTTGCGTGTGCGTGGCAGTGTGCGTGGCAGGA
TGTGCGTGCGTGTGTAACCCGAGCCGCCCGATCTGTTTCGATCTGCGCCGCGGAGCCCTCCCTCAAGGCCCGCTCCACCTGCTGCGGTTA
CGCGGCGCTCGTGGGTGTTCGTGCCTCGGAGCAGCTAACCGGCGGGTGCTGGGCGACGGTGGAGGAGTATCGTCTCGCTGCTGCCCGAGT
CAGGGCTGAGTCACCCAGCTGATGTAGACAGTGGCTGCCTTCCGAAGAGTGCGTGTTTGCATGTGTGTGACTCTGCGGCTGCTCAACTCC
CAACAAACCAGAGGACCAGCCACAAACTTAACCAACATCCCCAAACCCGAGTTCACAGATGTGGGAGAGCTGTAGAACCCTGAGTGTCAT
CGACTGGGCCTTCTTATGATTGTTGTTTTAAGATTAGCTGAAGATCTCTGAAACGCTGAATTTTCTGCACTGAGCGTTTTGACAGAATTC
ATTGAGAGAACAGAGAACATGACAAGTACTTCTAGCTCAGCACTGCTCCAACTACTGAAGCTGATTTTCAAGGCTACTTAAAAAAATCTG
CAGCGTACATTAATGGATTTCTGTTGTGTTTAAATTCTCCACAGATTGTATTGTAAATATTTTATGAAGTAGAGCATATGTATATATTTA
TATATACGTGCACATACATTAGTAGCACTACCTTTGGAAGTCTCAGCTCTTGCTTTTCGGGACTGAAGCCAGTTTTGCATGATAAAAGTG
GCCTTGTTACGGGAGATAATTGTGTTCTGTTGGGACTTTAGACAAAACTCACCTGCAAAAAACTGACAGGCATTAACTACTGGAACTTCC
AAATAATGTGTTTGCTGATCGTTTTACTCTTCGCATAAATATTTTAGGAAGTGTATGAGAATTTTGCCTTCAGGAACTTTTCTAACAGCC
AAAGACAGAACTTAACCTCTGCAAGCAAGATTCGTGGAAGATAGTCTCCACTTTTTAATGCACTAAGCAATCGGTTGCTAGGAGCCCATC
CTGGGTCAGAGGCCGATCCGCAGAACCAGAACGTTTTCCCCTCCTGGACTGTTAGTAACTTAGTCTCCCTCCTCCCCTAACCACCCCCGC
CCCCCCCCACCCCCCGCAGTAATAAAGGCCCCTGAACGTGTATGTTGGTCTCCCGGGAGCTGCTTGCTGAAGATCCGCGCCCCTGTCGCC
GTCTGGTAGGAGCTGTTTGCAGGGTCCTAACTCAATCGGCTTGTTGTGATGCGTATCCCCGTAGATGCCAGCACGAGCCGCCGCTTCACG
CCGCCTTCCACCGCGCTGAGCCCAGGCAAGATGAGCGAGGCGTTGCCGCTGGGCGCCCCGGACGCCGGCGCTGCCCTGGCCGGCAAGCTG
AGGAGCGGCGACCGCAGCATGGTGGAGGTGCTGGCCGACCACCCGGGCGAGCTGGTGCGCACCGACAGCCCCAACTTCCTCTGCTCCGTG
CTGCCTACGCACTGGCGCTGCAACAAGACCCTGCCCATCGCTTTCAAGGTGGTGGCCCTAGGGGATGTTCCAGATGGCACTCTGGTCACT
GTGATGGCTGGCAATGATGAAAACTACTCGGCTGAGCTGAGAAATGCTACCGCAGCCATGAAGAACCAGGTTGCAAGATTTAATGACCTC
AGGTTTGTCGGTCGAAGTGGAAGAGGGAAAAGCTTCACTCTGACCATCACTGTCTTCACAAACCCACCGCAAGTCGCCACCTACCACAGA
GCCATCAAAATCACAGTGGATGGGCCCCGAGAACCTCGAATTGGTCCTGAGAAAAGGGTGCCAGCGATGCCTGGATCGCCTGTGGAAGTG
AAGATACAGTCCAGATCCTCACCTCCCACCATGCCACCCCTCCCACCAATAAATCCTGGAGGACCGAGGCCAGTGTCCTTCACTCCTACT
GCATTAAGCAATGGCATCAACCATTCTCCTCCTACCCTGAATGGTGCCCCATCACCGCCACAGAGATTCAGCAATGGTCCTGCCTCCTCC
ACATCATCTGCACTCACAAATCAGCAATTGCCAGCCACTTGTGGTGCTCGACAACTCAGCAAGTTGAAACGCTTTCTTACCACTCTGCAA
CAGTTTGGCAATGACATCTCCCCTGAGATTGGGGAGAAGGTGCGGACTCTTGTTCTTGCACTGGTGAACTCAACAGTGACAATTGAGGAA
TTCCACTGTAAGCTCCAAGAAGCCACAAACTTTCCCCTTCGTCCTTTTGTGATTCCATTTCTCAAGGCCAACCTGCCCCTGCTGCAGCGG
GAACTGCTGCACTGCGCTCGGGCGGCCAAGCAGACCCCATCCCAGTACCTGGCTCAGCACGAACACCTTCTGCTCAACACAAGCATTGCA
TCGCCTGCTGACTCGTCAGAGTTGCTCATGGAGGTGCACGGAAATGGGAAGAGGCCCAGTCCAGAGAGGAGAGAAGAGAATAGTTTTGAT
AGAGACACAATTGCTCCTGAGCCTCCTGCCAAGAGAGTATGTACCATCAGCCCTGCTCCTCGGCACAGTCCTGCTCTCACTGTGCCCCTC
ATGAATCCCGGGGGCCAATTCCATCCTACCCCTCCACCTCTTCAGCATTACACCTTAGAGGATATTGCAACTTCTCACCTGTATCGGGAA
CCCAACAAGATGCTAGAGCATCGAGAAGTTCGTGATAGACACCACAGTCTTGGTCTAAATGGAGGCTATCAAGATGAGTTGGTAGATCAT
CGTTTGACAGAAAGGGAATGGGCTGATGAATGGAAACATCTTGACCATGCGCTGAATTGCATTATGGAAATGGTAGAGAAAACAAGGCGC
TCTATGGCAGTTCTGCGGCGCTGTCAGGAATCAGATCGTGAAGAACTCAACTACTGGAAAAGACGGTACAATGAAAACACAGAGCTGAGG
AAAACGGGGACCGAGTTGGTCTCCAGGCAGCACAGCCCTGGGAGTGCAGATTCTCTCAGCAATGATTCTCAGAGAGAGTTCAACAGCAGG
CCAGGTACAGGATACGTACCTGTGGAGTTTTGGAAAAAAACAGAAGAAGCTGTGAATAAGGTGAAAATTCAGGCCATGTCAGAAGTACAG
AAGGCCGTCGCTGAGGCAGAGCAGAAAGCCTTTGAAGTGATTGCAACAGAGAGAGCACGAATGGAGCAAACCATAGCGGATGTCAAGCGG
CAGGCCGCAGAGGATGCTTTCCTCGTCATCAATGAGCAAGAGGAGTCCACGGAGAACTGCTGGAACTGTGGCCGCAAAGCCAGCGAGACA
TGCAGTGGCTGCAATATCGCGCGATACTGTGGCTCTTTCTGCCAGCACAAGGACTGGGAGCGGCACCACCGCCTCTGTGGTCAGAACCTG
CATGGCCAGAGCCCCCACGGCCAGGGCCGGCCGCTGCTTCCTGTAGGCAGGGGCTCCTCTGCCAGGTCCGCCGACTGCAGCGTGCCCAGC
CCAGCCCTCGACAAGACCTCGGCAACCACATCGCGTTCCTCAACACCTGCTTCTGTGACAGCTATCGACACCAACGGACTCTGAGCCCCG
GACTCTGCTTACCCTGATGGCTGCTCAGCACCACAGAGTGCTTGGGCTGAGGGACTGACTGTTGGAACCCGTGCATGTAGCTGCCGGGTC
ATCAGCAAGAAATGAATTGGAGGCAGGAAGAGTCCAAGCCTGAATAATAACACCCCACAGCCTCTCTGTGCACTTGCTGTCTGCGGAGCC
AGTGTGCCATTCTCTGCACATGGGCAGCCAGCCTGAGCTGCCTCCTCCATGGCTTTCCTGGTTTGTTCCTCTCTCCACTGAAGCTGACTT
AGCCGGCCCCTTTTCAGTGTAGACCACCAGCTCCCCTCCCCATCTCCTTGAGTCAGCAGACTGTCCAATGTGCTCAGCCAGGCTGGAGGC
GGCAGGCGGCAGGCAGCAGGCTGTGGAGGAGGCCCCTCGGTCAGGGAGCGGCCTGCCTCACCCCTGAATAGCTCCTTCGGCCCCATCTCC
ATCCTCAGCAGATGACACTGATTGGCCTCACGGGGACTTGGGTAAGCAACAGGCGGCATTCAGGACTCTTCTCAACCCTGCTGTTCAGAC
TTGATAAGATCTCAGAGTCCACAGGAAAGAAGTCACTGTTGCAATAAAAGCACCCGTAGTAGCAAAAACATAAAACAAATAAAACTTCCC
CCACATCACAGATGATTTTGGACAAGATTTTCCAACCTTGCTGGCTACTTTAGTTTGGGACCTGTTTTTTTTCTCATTTGATTTTGCTTG
TGCAGAAAATAGTTTCCAGCACATGGATTGATCTGAGAGAGAATGAGGCTCAGTTGTGGATAGTCTGTTTTCTCTGAGCATGTTGGCCAA

>78645_78645_7_RUNX1-CBFA2T2_RUNX1_chr21_36231771_ENST00000358356_CBFA2T2_chr20_32194762_ENST00000342704_length(amino acids)=761AA_BP=178
MRIPVDASTSRRFTPPSTALSPGKMSEALPLGAPDAGAALAGKLRSGDRSMVEVLADHPGELVRTDSPNFLCSVLPTHWRCNKTLPIAFK
VVALGDVPDGTLVTVMAGNDENYSAELRNATAAMKNQVARFNDLRFVGRSGRGKSFTLTITVFTNPPQVATYHRAIKITVDGPREPRIGP
EKRVPAMPGSPVEVKIQSRSSPPTMPPLPPINPGGPRPVSFTPTALSNGINHSPPTLNGAPSPPQRFSNGPASSTSSALTNQQLPATCGA
RQLSKLKRFLTTLQQFGNDISPEIGEKVRTLVLALVNSTVTIEEFHCKLQEATNFPLRPFVIPFLKANLPLLQRELLHCARAAKQTPSQY
LAQHEHLLLNTSIASPADSSELLMEVHGNGKRPSPERREENSFDRDTIAPEPPAKRVCTISPAPRHSPALTVPLMNPGGQFHPTPPPLQH
YTLEDIATSHLYREPNKMLEHREVRDRHHSLGLNGGYQDELVDHRLTEREWADEWKHLDHALNCIMEMVEKTRRSMAVLRRCQESDREEL
NYWKRRYNENTELRKTGTELVSRQHSPGSADSLSNDSQREFNSRPGTGYVPVEFWKKTEEAVNKVKIQAMSEVQKAVAEAEQKAFEVIAT
ERARMEQTIADVKRQAAEDAFLVINEQEESTENCWNCGRKASETCSGCNIARYCGSFCQHKDWERHHRLCGQNLHGQSPHGQGRPLLPVG

--------------------------------------------------------------
>78645_78645_8_RUNX1-CBFA2T2_RUNX1_chr21_36231771_ENST00000358356_CBFA2T2_chr20_32194762_ENST00000375279_length(transcript)=9254nt_BP=2110nt
CATAGAGCCAGCGGGCGCGGGCGGGACGGGCGCCCCGCGGCCGGACCCAGCCAGGGCACCACGCTGCCCGGCCCTGCGCCGCCAGGCACT
TCTTTCCGGGGCTCCTAGGGACGCCAGAAGGAAGTCAACCTCTGCTGCTTCTCCTTGGCCTGCGTTGGACCTTCCTTTTTTTGTTGTTTT
TTTTTGTTTTTCCCCTTTCTTCCTTTTGAATTAACTGGCTTCTTGGCTGGATGTTTTCAACTTCTTTCCTGGCTGCGAACTTTTCCCCAA
TTGTTTTCCTTTTACAACAGGGGGAGAAAGTGCTCTGTGGTCCGAGGCGAGCCGTGAAGTTGCGTGTGCGTGGCAGTGTGCGTGGCAGGA
TGTGCGTGCGTGTGTAACCCGAGCCGCCCGATCTGTTTCGATCTGCGCCGCGGAGCCCTCCCTCAAGGCCCGCTCCACCTGCTGCGGTTA
CGCGGCGCTCGTGGGTGTTCGTGCCTCGGAGCAGCTAACCGGCGGGTGCTGGGCGACGGTGGAGGAGTATCGTCTCGCTGCTGCCCGAGT
CAGGGCTGAGTCACCCAGCTGATGTAGACAGTGGCTGCCTTCCGAAGAGTGCGTGTTTGCATGTGTGTGACTCTGCGGCTGCTCAACTCC
CAACAAACCAGAGGACCAGCCACAAACTTAACCAACATCCCCAAACCCGAGTTCACAGATGTGGGAGAGCTGTAGAACCCTGAGTGTCAT
CGACTGGGCCTTCTTATGATTGTTGTTTTAAGATTAGCTGAAGATCTCTGAAACGCTGAATTTTCTGCACTGAGCGTTTTGACAGAATTC
ATTGAGAGAACAGAGAACATGACAAGTACTTCTAGCTCAGCACTGCTCCAACTACTGAAGCTGATTTTCAAGGCTACTTAAAAAAATCTG
CAGCGTACATTAATGGATTTCTGTTGTGTTTAAATTCTCCACAGATTGTATTGTAAATATTTTATGAAGTAGAGCATATGTATATATTTA
TATATACGTGCACATACATTAGTAGCACTACCTTTGGAAGTCTCAGCTCTTGCTTTTCGGGACTGAAGCCAGTTTTGCATGATAAAAGTG
GCCTTGTTACGGGAGATAATTGTGTTCTGTTGGGACTTTAGACAAAACTCACCTGCAAAAAACTGACAGGCATTAACTACTGGAACTTCC
AAATAATGTGTTTGCTGATCGTTTTACTCTTCGCATAAATATTTTAGGAAGTGTATGAGAATTTTGCCTTCAGGAACTTTTCTAACAGCC
AAAGACAGAACTTAACCTCTGCAAGCAAGATTCGTGGAAGATAGTCTCCACTTTTTAATGCACTAAGCAATCGGTTGCTAGGAGCCCATC
CTGGGTCAGAGGCCGATCCGCAGAACCAGAACGTTTTCCCCTCCTGGACTGTTAGTAACTTAGTCTCCCTCCTCCCCTAACCACCCCCGC
CCCCCCCCACCCCCCGCAGTAATAAAGGCCCCTGAACGTGTATGTTGGTCTCCCGGGAGCTGCTTGCTGAAGATCCGCGCCCCTGTCGCC
GTCTGGTAGGAGCTGTTTGCAGGGTCCTAACTCAATCGGCTTGTTGTGATGCGTATCCCCGTAGATGCCAGCACGAGCCGCCGCTTCACG
CCGCCTTCCACCGCGCTGAGCCCAGGCAAGATGAGCGAGGCGTTGCCGCTGGGCGCCCCGGACGCCGGCGCTGCCCTGGCCGGCAAGCTG
AGGAGCGGCGACCGCAGCATGGTGGAGGTGCTGGCCGACCACCCGGGCGAGCTGGTGCGCACCGACAGCCCCAACTTCCTCTGCTCCGTG
CTGCCTACGCACTGGCGCTGCAACAAGACCCTGCCCATCGCTTTCAAGGTGGTGGCCCTAGGGGATGTTCCAGATGGCACTCTGGTCACT
GTGATGGCTGGCAATGATGAAAACTACTCGGCTGAGCTGAGAAATGCTACCGCAGCCATGAAGAACCAGGTTGCAAGATTTAATGACCTC
AGGTTTGTCGGTCGAAGTGGAAGAGGGAAAAGCTTCACTCTGACCATCACTGTCTTCACAAACCCACCGCAAGTCGCCACCTACCACAGA
GCCATCAAAATCACAGTGGATGGGCCCCGAGAACCTCGAATTGGTCCTGAGAAAAGGGTGCCAGCGATGCCTGGATCGCCTGTGGAAGTG
AAGATACAGTCCAGATCCTCACCTCCCACCATGCCACCCCTCCCACCAATAAATCCTGGAGGACCGAGGCCAGTGTCCTTCACTCCTACT
GCATTAAGCAATGGCATCAACCATTCTCCTCCTACCCTGAATGGTGCCCCATCACCGCCACAGAGATTCAGCAATGGTCCTGCCTCCTCC
ACATCATCTGCACTCACAAATCAGCAATTGCCAGCCACTTGTGGTGCTCGACAACTCAGCAAGTTGAAACGCTTTCTTACCACTCTGCAA
CAGTTTGGCAATGACATCTCCCCTGAGATTGGGGAGAAGGTGCGGACTCTTGTTCTTGCACTGGTGAACTCAACAGTGACAATTGAGGAA
TTCCACTGTAAGCTCCAAGAAGCCACAAACTTTCCCCTTCGTCCTTTTGTGATTCCATTTCTCAAGGCCAACCTGCCCCTGCTGCAGCGG
GAACTGCTGCACTGCGCTCGGGCGGCCAAGCAGACCCCATCCCAGTACCTGGCTCAGCACGAACACCTTCTGCTCAACACAAGCATTGCA
TCGCCTGCTGACTCGTCAGAGTTGCTCATGGAGGTGCACGGAAATGGGAAGAGGCCCAGTCCAGAGAGGAGAGAAGAGAATAGTTTTGAT
AGAGACACAATTGCTCCTGAGCCTCCTGCCAAGAGAGTATGTACCATCAGCCCTGCTCCTCGGCACAGTCCTGCTCTCACTGTGCCCCTC
ATGAATCCCGGGGGCCAATTCCATCCTACCCCTCCACCTCTTCAGCATTACACCTTAGAGGATATTGCAACTTCTCACCTGTATCGGGAA
CCCAACAAGATGCTAGAGCATCGAGAAGTTCGTGATAGACACCACAGTCTTGGTCTAAATGGAGGCTATCAAGATGAGTTGGTAGATCAT
CGTTTGACAGAAAGGGAATGGGCTGATGAATGGAAACATCTTGACCATGCGCTGAATTGCATTATGGAAATGGTAGAGAAAACAAGGCGC
TCTATGGCAGTTCTGCGGCGCTGTCAGGAATCAGATCGTGAAGAACTCAACTACTGGAAAAGACGGTACAATGAAAACACAGAGCTGAGG
AAAACGGGGACCGAGTTGGTCTCCAGGCAGCACAGCCCTGGGAGTGCAGATTCTCTCAGCAATGATTCTCAGAGAGAGTTCAACAGCAGG
CCAGGTACAGGATACGTACCTGTGGAGTTTTGGAAAAAAACAGAAGAAGCTGTGAATAAGGTGAAAATTCAGGCCATGTCAGAAGTACAG
AAGGCCGTCGCTGAGGCAGAGCAGAAAGCCTTTGAAGTGATTGCAACAGAGAGAGCACGAATGGAGCAAACCATAGCGGATGTCAAGCGG
CAGGCCGCAGAGGATGCTTTCCTCGTCATCAATGAGCAAGAGGAGTCCACGGAGAACTGCTGGAACTGTGGCCGCAAAGCCAGCGAGACA
TGCAGTGGCTGCAATATCGCGCGATACTGTGGCTCTTTCTGCCAGCACAAGGACTGGGAGCGGCACCACCGCCTCTGTGGTCAGAACCTG
CATGGCCAGAGCCCCCACGGCCAGGGCCGGCCGCTGCTTCCTGTAGGCAGGGGCTCCTCTGCCAGGTCCGCCGACTGCAGCGTGCCCAGC
CCAGCCCTCGACAAGACCTCGGCAACCACATCGCGTTCCTCAACACCTGCTTCTGTGACAGCTATCGACACCAACGGACTCTGAGCCCCG
GACTCTGCTTACCCTGATGGCTGCTCAGCACCACAGAGTGCTTGGGCTGAGGGACTGACTGTTGGAACCCGTGCATGTAGCTGCCGGGTC
ATCAGCAAGAAATGAATTGGAGGCAGGAAGAGTCCAAGCCTGAATAATAACACCCCACAGCCTCTCTGTGCACTTGCTGTCTGCGGAGCC
AGTGTGCCATTCTCTGCACATGGGCAGCCAGCCTGAGCTGCCTCCTCCATGGCTTTCCTGGTTTGTTCCTCTCTCCACTGAAGCTGACTT
AGCCGGCCCCTTTTCAGTGTAGACCACCAGCTCCCCTCCCCATCTCCTTGAGTCAGCAGACTGTCCAATGTGCTCAGCCAGGCTGGAGGC
GGCAGGCGGCAGGCAGCAGGCTGTGGAGGAGGCCCCTCGGTCAGGGAGCGGCCTGCCTCACCCCTGAATAGCTCCTTCGGCCCCATCTCC
ATCCTCAGCAGATGACACTGATTGGCCTCACGGGGACTTGGGTAAGCAACAGGCGGCATTCAGGACTCTTCTCAACCCTGCTGTTCAGAC
TTGATAAGATCTCAGAGTCCACAGGAAAGAAGTCACTGTTGCAATAAAAGCACCCGTAGTAGCAAAAACATAAAACAAATAAAACTTCCC
CCACATCACAGATGATTTTGGACAAGATTTTCCAACCTTGCTGGCTACTTTAGTTTGGGACCTGTTTTTTTTCTCATTTGATTTTGCTTG
TGCAGAAAATAGTTTCCAGCACATGGATTGATCTGAGAGAGAATGAGGCTCAGTTGTGGATAGTCTGTTTTCTCTGAGCATGTTGGCCAA
CTAGTATCGTCAAATTATTGAGTGGATCATCTCTTGGAAATGCAGAACTTCTGCCACCACTTGGCTATTTGCACAGTCATCTTGTTCTGT
GTCCTTTTATCTCTCAGACCACACACATCTGGAACGCTGTGGGCATCTTCTGCCCATGGGCTCCATTTGGCACCTGCTGAGCCACAGTTG
TCCTGCTGGATGTGCTGTGCAGGTTGGTAGGACTTGCCCCCACTGTCAAGGCCTGGTCTCATCTGAAAAGCCCTCCTGGACCTCAAAGAA
TTCTTCAGACCTCATAGTTACAGGTCATTATATCTACTATGTTGATTTATCATCAGGCACACAACTTCTGTTTCCTTCTCTTGTGTTATC
TGATAGCGTCCCTCCTTGAGCTCATCAGAAAGGTTTTATGAAATGTGAACCATTTTGGGAAAAGCTGATCAATTTTTCTTCCTAGCTTCC
CATTTTCAAATGGGACATCACTCATATCCCTTTCAGAATGTTAGGAACTGCCTCCCACATTCTTCCCTGTCTTTTTGGGTTTTGTTTTTT
GTTGTTGTGGTGGTTTTTTAACACAAAGTCTCACTCTGTTGCCCAGGCTGGAGTGCAGTGGCATGATCTTGGCTCACTGCAACCTCTGCC
TTCCAGGTTCAAGCAATTCTCCTGCCTCAGCCTCCCGAGTAGCTGAGATTACAGGCGCCCACCACCACGCCCAGCTAATTTTTGTATTTT
TAGTAGAGACAGGGTTTCACCATGTTGGCCAGGCTGATCTCGAACTCCTGACCTCAGGTGACCTGCCTTGGCCTCCCAAAGTGCAGGGAT
TACAAGCGTGAGCCACCATGCCCGGCCTGTCTTTTTGGTTTTGATGGGAGTCTGAGGACCCCGACCCCTCCTGCTCTCCATCTTTGAGCC
TCTGGCATCCTCTCACACCCAGAAATCAGTTGGAGTAAGTTTAATTGGCCCTGCTCCAGCTGGCCTTTGAAGCACAAGTTTAAATCTCCA
CCTTCTGTGCACTGACCAGAGTCTAAAATAAAAGTTGTCAGTACCATAAAGGAAAAGGGATCCACACAGGTAGCCTTCTCCTTGGATACA
GGTACATCTTACTGTAAGAATTTCAAGTCCTGGCTGGGCGCAGTGGCTCACTCCTGTAATCCCAGCACTTTGAGAGACCGAGGCAGGCAG
ATCACTTGAGGTCAGGAATTCAAGACCAACCTGGCCAACATGGTGAAACCCTGTCTCTAATAAAAAAAAAATAGAAAAATCAGCCGGGTG
TGGTGGCACACACCTGTAATCCTAGCTACTCAGGAGGCTGAGGCAAGAGAATCTCTTGAACCTGTGAGCCAGAGGTTGCAGTGAGCCGAG
ATTCCACCACTGCACTCCAGCCTGGGCAACAGAGCAAAACTCTGTCTCAAAAAAAAAAAAAAAAAGGCAAAATTAAAGAATTTCAAGTCC
CTAATTTACTCTAACCAAGCATTTTCAGTCTTACAAAGAAATCTAGTGCACGACACCTTTAAAATGCCTAGATTTCCATTGCCTAAAGTA
AGGTGTGACCAGTGAAACAACAGCAGAGAATCATGTTCCTTTGCTGTGGAACACATAAGCCCCACAGTTTTCCAGTCAGCCTAATACATG
GGTATCCCCCGACCCCATCTGCCTCCTTAAGCCACAGTCCTTGGTGGGGAACTCTAAGGGGGACGGAGTCAGTACCCCGGACAGGGCCAC
ATTTGCATGAGACATGGCTGTCTCACAGGTCACAGAGCCATTACAACAGCTTACTAGTTTTTCATGGATTTGTTGGATTAACACCTTAAG
CAGGTTTTTTATTGTTATTTTGTTTGTTTGTTTGTTTTGAGACGGGAGTTTCTCTCTTGTCTCCCAGGCTGGAGTGCAATCGCGCAATCT
CGGCTCACGGTAACCTCTGCCTCCCAGGTTCAAGCGAGTCTCCTGCCTCAGCCTTCTGAGTAGCTGGGATTACAGGCATGCGCCACCACG
CCCAACTAATTTTGTATTTTTAGTAGAGACGGGGTTTCTCCTTGTTGGTCAGGCTGGTCTCAAACCCCGGACCTCAGGTGATCCCCCCAC
CTTGGCCTCCCAAAGTGCCAGGATTACAGGCATGAGCCACTGTGTCCGGTCTTGAGCAGGTTTTTAAAATCTCCAGTGGCCATAAAACTA
GCCAGGGTAGCTCATGCTTTTACTGGTTGGAATAAGGAGCCAAAACCAACAAAATAATATTTATTAGGGCTCGATGCCCATTTCTGTGGC
TAAGGCTTAGGTTTGGTGTGCAGAGCCTGGCCTGCTCTTGTGGGCTGTGGTTGCTGTGACAGTTTCGTTTTCTGAATCTTTGTAATGCTC
TTCCACCCTGCTCGTGCTGCCCAGAGGCTGATCTGCAAACCTGGGCAGTATTCCACACTGAAGCTCAGTTTGCAAACCTTCTGCTGTGTT
AATTCTGGTCAGTTTCACACAGAAGTCACGAGGGCCTCTGCCCAGGACCTTCTATTCACATTTCAAGAATCCCTTTCTGAAATTCTCCAA
CTCTCTGGTCAGGAGGAGGAGCACCATTGGGGCGGGGTAGGCAGCTAGAGGCGCAGGAGCGAATCCAGGTTCCTTGCGTGGTTCCCAGCC
TCTGCTGACAGCACCTCAGCTACCAGGTGGGGAGTGGAAATTCAGCCTGCTTAGAGGACTGACCTCTACAGTTCATATTTGCAGTGACAT
AAAAGGCAAAGAGGAGCTGGCATGGTGGTACAGAAGGTATCAGTCAAGCGCAGGCTCTTCAGAAACCTAGAAACTAAAAAGAGATGCAAC
ATGTGACTGGCCATCAGCCAGACATGTCTAGGGTGAGACCAGTGCTCAGCACCACCCGCCAAGGAACACTGATGAGTTGTGGGACATTAT
GGTCGGCCAAGTGAGGAATGATTGCAGGGACCAGAGAAGACCAAAGATGCCAGATGTCCCCAGAGTTTCTTGAGGGCTGGGTTTCACGTC
TTTGCTTGTCCTTTTTGTCCCCACTTGCCTGCACCGTGCCTGACTCATCCAGTGGGGAAGGTGACTCAAGAAGTTGTTTAAGCCTAGGCC
TAGGCAGTCCACTTCGGGAGGTGGGGGCACTCCACACTGGGGGGCCCTGCAGCTCCAGGGCTGGTGCTCTAGCAGATCCGCTCAGGCACG
GTTGGGTGACCGTGGGGTCACCGATTGCGTAGATTATTTCTAGGGCAGTGCTGGGTTAGAAATGTCTGTCTGGAAACAGGACACATCTTG
CCACCACAAGTCCACACCTGGCCTTGGCTGCTGCCCGCTCTCTGCAGCGTGGATTTCCTTTGCCCATTTGGGCCAGAAGGTCACCAGGAG
TTCATCACTGCTTAGTGTCAACTTGACATCTTCAGCTTCCAGACAGAAAACCCATGCTTTACTTTGTACAGCCCTGTCCCAGAGTTAGTA
AGCCTCGGCTTGTCACCTGCTTGCAAAGGGTATAGACATCATTCTGGGTAGTTCTAGAGGATATCGCAACAAGTGCGTTTGAAGGTTCAG
CACAGCTGGAATTGTACGGTAGTGAGCTCTTCAAAATGAAAACAGAATGACCGGATGGCCATCTGTCCTGGAAACTGTAGAATTGAATAA
ATCACTGAAAATAGAACACTTCTTGGAGGCTTTCTTCAGAACTGAACTAGAAACAAGGTTTCCAGGCTCCCAGGTCAGTAGACCAAACCA
ACTTCCTTAGATTTTTTTTTTTAAGCTGTTTGCAGAAAACTGGGTGGTAGCGTGTCTGAACCAAACGGAAGAATAGCCAGCGGAGCATGG
ACTGTTCCAGCACGGGCCAGATGGCCAGCTGTCGAGAGCAGCCCTGCCCAGATTGCGGTGGGGGCTGTGCCAGCGGCTCCGCAGGGCCCT
TCCAACTCTGGAGTGTCTGTAGTTCTTGTGAAACCAAAACGTTGACTACCTGCCTCTTTCCTCGGGCATCGACGTGCTCATTTCCAAAGA
TGATGGTGCAGGTGACCTTTTCCATCGTGAGCTAAGAGAAGGTTAGGAGGCCTGAGGGGCGGGCCTTGTGTCCCCTCCTCCCCCTCCACA
GCCCCTGAGGTGGAGCTTCCCTCACAGACCCCATCTGGTCGAGCCTACGGCTGCCCAGTGTACACTCAGTGATGCTTATACCAAATAGGG
CATGTGCGCTGGTGTCTGTTGGGGACAGCCCCATCCCTACCTTGGAGTCGGCAGAGAAGCAGCAATAAGCATTAGGCGAATGATTGAAAG
GGCTGCTGCGCCAAGAGGCCTTCAGTCCCCTTAACGTGGCTTTCCAACTTCCTGACGAGGCTACAAAGGCTCCGCTCACAAAAGAAAGCC
AATAATGTAAATAAATAGAAAACGAAGCCTCCACGCGTGGTTTTTAAAGGGGGATGATGAATGTGACACCACCCACAGAATGCATTAGAA
TCTGGTTTTTCTGTGCTTTGTCATTTTACTCTGATAGGAATTTTTGTTACCTAACTCTGTGCATAACTTATTTAATGTACTGTATAAATG

>78645_78645_8_RUNX1-CBFA2T2_RUNX1_chr21_36231771_ENST00000358356_CBFA2T2_chr20_32194762_ENST00000375279_length(amino acids)=761AA_BP=178
MRIPVDASTSRRFTPPSTALSPGKMSEALPLGAPDAGAALAGKLRSGDRSMVEVLADHPGELVRTDSPNFLCSVLPTHWRCNKTLPIAFK
VVALGDVPDGTLVTVMAGNDENYSAELRNATAAMKNQVARFNDLRFVGRSGRGKSFTLTITVFTNPPQVATYHRAIKITVDGPREPRIGP
EKRVPAMPGSPVEVKIQSRSSPPTMPPLPPINPGGPRPVSFTPTALSNGINHSPPTLNGAPSPPQRFSNGPASSTSSALTNQQLPATCGA
RQLSKLKRFLTTLQQFGNDISPEIGEKVRTLVLALVNSTVTIEEFHCKLQEATNFPLRPFVIPFLKANLPLLQRELLHCARAAKQTPSQY
LAQHEHLLLNTSIASPADSSELLMEVHGNGKRPSPERREENSFDRDTIAPEPPAKRVCTISPAPRHSPALTVPLMNPGGQFHPTPPPLQH
YTLEDIATSHLYREPNKMLEHREVRDRHHSLGLNGGYQDELVDHRLTEREWADEWKHLDHALNCIMEMVEKTRRSMAVLRRCQESDREEL
NYWKRRYNENTELRKTGTELVSRQHSPGSADSLSNDSQREFNSRPGTGYVPVEFWKKTEEAVNKVKIQAMSEVQKAVAEAEQKAFEVIAT
ERARMEQTIADVKRQAAEDAFLVINEQEESTENCWNCGRKASETCSGCNIARYCGSFCQHKDWERHHRLCGQNLHGQSPHGQGRPLLPVG

--------------------------------------------------------------
>78645_78645_9_RUNX1-CBFA2T2_RUNX1_chr21_36231771_ENST00000399240_CBFA2T2_chr20_32194762_ENST00000342704_length(transcript)=3252nt_BP=603nt
TGAAGATCCGCGCCCCTGTCGCCGTCTGGTAGGAGCTGTTTGCAGGGTCCTAACTCAATCGGCTTGTTGTGATGCGTATCCCCGTAGATG
CCAGCACGAGCCGCCGCTTCACGCCGCCTTCCACCGCGCTGAGCCCAGGCAAGATGAGCGAGGCGTTGCCGCTGGGCGCCCCGGACGCCG
GCGCTGCCCTGGCCGGCAAGCTGAGGAGCGGCGACCGCAGCATGGTGGAGGTGCTGGCCGACCACCCGGGCGAGCTGGTGCGCACCGACA
GCCCCAACTTCCTCTGCTCCGTGCTGCCTACGCACTGGCGCTGCAACAAGACCCTGCCCATCGCTTTCAAGGTGGTGGCCCTAGGGGATG
TTCCAGATGGCACTCTGGTCACTGTGATGGCTGGCAATGATGAAAACTACTCGGCTGAGCTGAGAAATGCTACCGCAGCCATGAAGAACC
AGGTTGCAAGATTTAATGACCTCAGGTTTGTCGGTCGAAGTGGAAGAGGGAAAAGCTTCACTCTGACCATCACTGTCTTCACAAACCCAC
CGCAAGTCGCCACCTACCACAGAGCCATCAAAATCACAGTGGATGGGCCCCGAGAACCTCGAATTGGTCCTGAGAAAAGGGTGCCAGCGA
TGCCTGGATCGCCTGTGGAAGTGAAGATACAGTCCAGATCCTCACCTCCCACCATGCCACCCCTCCCACCAATAAATCCTGGAGGACCGA
GGCCAGTGTCCTTCACTCCTACTGCATTAAGCAATGGCATCAACCATTCTCCTCCTACCCTGAATGGTGCCCCATCACCGCCACAGAGAT
TCAGCAATGGTCCTGCCTCCTCCACATCATCTGCACTCACAAATCAGCAATTGCCAGCCACTTGTGGTGCTCGACAACTCAGCAAGTTGA
AACGCTTTCTTACCACTCTGCAACAGTTTGGCAATGACATCTCCCCTGAGATTGGGGAGAAGGTGCGGACTCTTGTTCTTGCACTGGTGA
ACTCAACAGTGACAATTGAGGAATTCCACTGTAAGCTCCAAGAAGCCACAAACTTTCCCCTTCGTCCTTTTGTGATTCCATTTCTCAAGG
CCAACCTGCCCCTGCTGCAGCGGGAACTGCTGCACTGCGCTCGGGCGGCCAAGCAGACCCCATCCCAGTACCTGGCTCAGCACGAACACC
TTCTGCTCAACACAAGCATTGCATCGCCTGCTGACTCGTCAGAGTTGCTCATGGAGGTGCACGGAAATGGGAAGAGGCCCAGTCCAGAGA
GGAGAGAAGAGAATAGTTTTGATAGAGACACAATTGCTCCTGAGCCTCCTGCCAAGAGAGTATGTACCATCAGCCCTGCTCCTCGGCACA
GTCCTGCTCTCACTGTGCCCCTCATGAATCCCGGGGGCCAATTCCATCCTACCCCTCCACCTCTTCAGCATTACACCTTAGAGGATATTG
CAACTTCTCACCTGTATCGGGAACCCAACAAGATGCTAGAGCATCGAGAAGTTCGTGATAGACACCACAGTCTTGGTCTAAATGGAGGCT
ATCAAGATGAGTTGGTAGATCATCGTTTGACAGAAAGGGAATGGGCTGATGAATGGAAACATCTTGACCATGCGCTGAATTGCATTATGG
AAATGGTAGAGAAAACAAGGCGCTCTATGGCAGTTCTGCGGCGCTGTCAGGAATCAGATCGTGAAGAACTCAACTACTGGAAAAGACGGT
ACAATGAAAACACAGAGCTGAGGAAAACGGGGACCGAGTTGGTCTCCAGGCAGCACAGCCCTGGGAGTGCAGATTCTCTCAGCAATGATT
CTCAGAGAGAGTTCAACAGCAGGCCAGGTACAGGATACGTACCTGTGGAGTTTTGGAAAAAAACAGAAGAAGCTGTGAATAAGGTGAAAA
TTCAGGCCATGTCAGAAGTACAGAAGGCCGTCGCTGAGGCAGAGCAGAAAGCCTTTGAAGTGATTGCAACAGAGAGAGCACGAATGGAGC
AAACCATAGCGGATGTCAAGCGGCAGGCCGCAGAGGATGCTTTCCTCGTCATCAATGAGCAAGAGGAGTCCACGGAGAACTGCTGGAACT
GTGGCCGCAAAGCCAGCGAGACATGCAGTGGCTGCAATATCGCGCGATACTGTGGCTCTTTCTGCCAGCACAAGGACTGGGAGCGGCACC
ACCGCCTCTGTGGTCAGAACCTGCATGGCCAGAGCCCCCACGGCCAGGGCCGGCCGCTGCTTCCTGTAGGCAGGGGCTCCTCTGCCAGGT
CCGCCGACTGCAGCGTGCCCAGCCCAGCCCTCGACAAGACCTCGGCAACCACATCGCGTTCCTCAACACCTGCTTCTGTGACAGCTATCG
ACACCAACGGACTCTGAGCCCCGGACTCTGCTTACCCTGATGGCTGCTCAGCACCACAGAGTGCTTGGGCTGAGGGACTGACTGTTGGAA
CCCGTGCATGTAGCTGCCGGGTCATCAGCAAGAAATGAATTGGAGGCAGGAAGAGTCCAAGCCTGAATAATAACACCCCACAGCCTCTCT
GTGCACTTGCTGTCTGCGGAGCCAGTGTGCCATTCTCTGCACATGGGCAGCCAGCCTGAGCTGCCTCCTCCATGGCTTTCCTGGTTTGTT
CCTCTCTCCACTGAAGCTGACTTAGCCGGCCCCTTTTCAGTGTAGACCACCAGCTCCCCTCCCCATCTCCTTGAGTCAGCAGACTGTCCA
ATGTGCTCAGCCAGGCTGGAGGCGGCAGGCGGCAGGCAGCAGGCTGTGGAGGAGGCCCCTCGGTCAGGGAGCGGCCTGCCTCACCCCTGA
ATAGCTCCTTCGGCCCCATCTCCATCCTCAGCAGATGACACTGATTGGCCTCACGGGGACTTGGGTAAGCAACAGGCGGCATTCAGGACT
CTTCTCAACCCTGCTGTTCAGACTTGATAAGATCTCAGAGTCCACAGGAAAGAAGTCACTGTTGCAATAAAAGCACCCGTAGTAGCAAAA
ACATAAAACAAATAAAACTTCCCCCACATCACAGATGATTTTGGACAAGATTTTCCAACCTTGCTGGCTACTTTAGTTTGGGACCTGTTT
TTTTTCTCATTTGATTTTGCTTGTGCAGAAAATAGTTTCCAGCACATGGATTGATCTGAGAGAGAATGAGGCTCAGTTGTGGATAGTCTG
TTTTCTCTGAGCATGTTGGCCAACTAGTATCGTCAAATTATTGAGTGGATCATCTCTTGGAAATGCAGAACTTCTGCCACCACTTGGCTA

>78645_78645_9_RUNX1-CBFA2T2_RUNX1_chr21_36231771_ENST00000399240_CBFA2T2_chr20_32194762_ENST00000342704_length(amino acids)=761AA_BP=178
MRIPVDASTSRRFTPPSTALSPGKMSEALPLGAPDAGAALAGKLRSGDRSMVEVLADHPGELVRTDSPNFLCSVLPTHWRCNKTLPIAFK
VVALGDVPDGTLVTVMAGNDENYSAELRNATAAMKNQVARFNDLRFVGRSGRGKSFTLTITVFTNPPQVATYHRAIKITVDGPREPRIGP
EKRVPAMPGSPVEVKIQSRSSPPTMPPLPPINPGGPRPVSFTPTALSNGINHSPPTLNGAPSPPQRFSNGPASSTSSALTNQQLPATCGA
RQLSKLKRFLTTLQQFGNDISPEIGEKVRTLVLALVNSTVTIEEFHCKLQEATNFPLRPFVIPFLKANLPLLQRELLHCARAAKQTPSQY
LAQHEHLLLNTSIASPADSSELLMEVHGNGKRPSPERREENSFDRDTIAPEPPAKRVCTISPAPRHSPALTVPLMNPGGQFHPTPPPLQH
YTLEDIATSHLYREPNKMLEHREVRDRHHSLGLNGGYQDELVDHRLTEREWADEWKHLDHALNCIMEMVEKTRRSMAVLRRCQESDREEL
NYWKRRYNENTELRKTGTELVSRQHSPGSADSLSNDSQREFNSRPGTGYVPVEFWKKTEEAVNKVKIQAMSEVQKAVAEAEQKAFEVIAT
ERARMEQTIADVKRQAAEDAFLVINEQEESTENCWNCGRKASETCSGCNIARYCGSFCQHKDWERHHRLCGQNLHGQSPHGQGRPLLPVG

--------------------------------------------------------------
>78645_78645_10_RUNX1-CBFA2T2_RUNX1_chr21_36231771_ENST00000399240_CBFA2T2_chr20_32194762_ENST00000375279_length(transcript)=7747nt_BP=603nt
TGAAGATCCGCGCCCCTGTCGCCGTCTGGTAGGAGCTGTTTGCAGGGTCCTAACTCAATCGGCTTGTTGTGATGCGTATCCCCGTAGATG
CCAGCACGAGCCGCCGCTTCACGCCGCCTTCCACCGCGCTGAGCCCAGGCAAGATGAGCGAGGCGTTGCCGCTGGGCGCCCCGGACGCCG
GCGCTGCCCTGGCCGGCAAGCTGAGGAGCGGCGACCGCAGCATGGTGGAGGTGCTGGCCGACCACCCGGGCGAGCTGGTGCGCACCGACA
GCCCCAACTTCCTCTGCTCCGTGCTGCCTACGCACTGGCGCTGCAACAAGACCCTGCCCATCGCTTTCAAGGTGGTGGCCCTAGGGGATG
TTCCAGATGGCACTCTGGTCACTGTGATGGCTGGCAATGATGAAAACTACTCGGCTGAGCTGAGAAATGCTACCGCAGCCATGAAGAACC
AGGTTGCAAGATTTAATGACCTCAGGTTTGTCGGTCGAAGTGGAAGAGGGAAAAGCTTCACTCTGACCATCACTGTCTTCACAAACCCAC
CGCAAGTCGCCACCTACCACAGAGCCATCAAAATCACAGTGGATGGGCCCCGAGAACCTCGAATTGGTCCTGAGAAAAGGGTGCCAGCGA
TGCCTGGATCGCCTGTGGAAGTGAAGATACAGTCCAGATCCTCACCTCCCACCATGCCACCCCTCCCACCAATAAATCCTGGAGGACCGA
GGCCAGTGTCCTTCACTCCTACTGCATTAAGCAATGGCATCAACCATTCTCCTCCTACCCTGAATGGTGCCCCATCACCGCCACAGAGAT
TCAGCAATGGTCCTGCCTCCTCCACATCATCTGCACTCACAAATCAGCAATTGCCAGCCACTTGTGGTGCTCGACAACTCAGCAAGTTGA
AACGCTTTCTTACCACTCTGCAACAGTTTGGCAATGACATCTCCCCTGAGATTGGGGAGAAGGTGCGGACTCTTGTTCTTGCACTGGTGA
ACTCAACAGTGACAATTGAGGAATTCCACTGTAAGCTCCAAGAAGCCACAAACTTTCCCCTTCGTCCTTTTGTGATTCCATTTCTCAAGG
CCAACCTGCCCCTGCTGCAGCGGGAACTGCTGCACTGCGCTCGGGCGGCCAAGCAGACCCCATCCCAGTACCTGGCTCAGCACGAACACC
TTCTGCTCAACACAAGCATTGCATCGCCTGCTGACTCGTCAGAGTTGCTCATGGAGGTGCACGGAAATGGGAAGAGGCCCAGTCCAGAGA
GGAGAGAAGAGAATAGTTTTGATAGAGACACAATTGCTCCTGAGCCTCCTGCCAAGAGAGTATGTACCATCAGCCCTGCTCCTCGGCACA
GTCCTGCTCTCACTGTGCCCCTCATGAATCCCGGGGGCCAATTCCATCCTACCCCTCCACCTCTTCAGCATTACACCTTAGAGGATATTG
CAACTTCTCACCTGTATCGGGAACCCAACAAGATGCTAGAGCATCGAGAAGTTCGTGATAGACACCACAGTCTTGGTCTAAATGGAGGCT
ATCAAGATGAGTTGGTAGATCATCGTTTGACAGAAAGGGAATGGGCTGATGAATGGAAACATCTTGACCATGCGCTGAATTGCATTATGG
AAATGGTAGAGAAAACAAGGCGCTCTATGGCAGTTCTGCGGCGCTGTCAGGAATCAGATCGTGAAGAACTCAACTACTGGAAAAGACGGT
ACAATGAAAACACAGAGCTGAGGAAAACGGGGACCGAGTTGGTCTCCAGGCAGCACAGCCCTGGGAGTGCAGATTCTCTCAGCAATGATT
CTCAGAGAGAGTTCAACAGCAGGCCAGGTACAGGATACGTACCTGTGGAGTTTTGGAAAAAAACAGAAGAAGCTGTGAATAAGGTGAAAA
TTCAGGCCATGTCAGAAGTACAGAAGGCCGTCGCTGAGGCAGAGCAGAAAGCCTTTGAAGTGATTGCAACAGAGAGAGCACGAATGGAGC
AAACCATAGCGGATGTCAAGCGGCAGGCCGCAGAGGATGCTTTCCTCGTCATCAATGAGCAAGAGGAGTCCACGGAGAACTGCTGGAACT
GTGGCCGCAAAGCCAGCGAGACATGCAGTGGCTGCAATATCGCGCGATACTGTGGCTCTTTCTGCCAGCACAAGGACTGGGAGCGGCACC
ACCGCCTCTGTGGTCAGAACCTGCATGGCCAGAGCCCCCACGGCCAGGGCCGGCCGCTGCTTCCTGTAGGCAGGGGCTCCTCTGCCAGGT
CCGCCGACTGCAGCGTGCCCAGCCCAGCCCTCGACAAGACCTCGGCAACCACATCGCGTTCCTCAACACCTGCTTCTGTGACAGCTATCG
ACACCAACGGACTCTGAGCCCCGGACTCTGCTTACCCTGATGGCTGCTCAGCACCACAGAGTGCTTGGGCTGAGGGACTGACTGTTGGAA
CCCGTGCATGTAGCTGCCGGGTCATCAGCAAGAAATGAATTGGAGGCAGGAAGAGTCCAAGCCTGAATAATAACACCCCACAGCCTCTCT
GTGCACTTGCTGTCTGCGGAGCCAGTGTGCCATTCTCTGCACATGGGCAGCCAGCCTGAGCTGCCTCCTCCATGGCTTTCCTGGTTTGTT
CCTCTCTCCACTGAAGCTGACTTAGCCGGCCCCTTTTCAGTGTAGACCACCAGCTCCCCTCCCCATCTCCTTGAGTCAGCAGACTGTCCA
ATGTGCTCAGCCAGGCTGGAGGCGGCAGGCGGCAGGCAGCAGGCTGTGGAGGAGGCCCCTCGGTCAGGGAGCGGCCTGCCTCACCCCTGA
ATAGCTCCTTCGGCCCCATCTCCATCCTCAGCAGATGACACTGATTGGCCTCACGGGGACTTGGGTAAGCAACAGGCGGCATTCAGGACT
CTTCTCAACCCTGCTGTTCAGACTTGATAAGATCTCAGAGTCCACAGGAAAGAAGTCACTGTTGCAATAAAAGCACCCGTAGTAGCAAAA
ACATAAAACAAATAAAACTTCCCCCACATCACAGATGATTTTGGACAAGATTTTCCAACCTTGCTGGCTACTTTAGTTTGGGACCTGTTT
TTTTTCTCATTTGATTTTGCTTGTGCAGAAAATAGTTTCCAGCACATGGATTGATCTGAGAGAGAATGAGGCTCAGTTGTGGATAGTCTG
TTTTCTCTGAGCATGTTGGCCAACTAGTATCGTCAAATTATTGAGTGGATCATCTCTTGGAAATGCAGAACTTCTGCCACCACTTGGCTA
TTTGCACAGTCATCTTGTTCTGTGTCCTTTTATCTCTCAGACCACACACATCTGGAACGCTGTGGGCATCTTCTGCCCATGGGCTCCATT
TGGCACCTGCTGAGCCACAGTTGTCCTGCTGGATGTGCTGTGCAGGTTGGTAGGACTTGCCCCCACTGTCAAGGCCTGGTCTCATCTGAA
AAGCCCTCCTGGACCTCAAAGAATTCTTCAGACCTCATAGTTACAGGTCATTATATCTACTATGTTGATTTATCATCAGGCACACAACTT
CTGTTTCCTTCTCTTGTGTTATCTGATAGCGTCCCTCCTTGAGCTCATCAGAAAGGTTTTATGAAATGTGAACCATTTTGGGAAAAGCTG
ATCAATTTTTCTTCCTAGCTTCCCATTTTCAAATGGGACATCACTCATATCCCTTTCAGAATGTTAGGAACTGCCTCCCACATTCTTCCC
TGTCTTTTTGGGTTTTGTTTTTTGTTGTTGTGGTGGTTTTTTAACACAAAGTCTCACTCTGTTGCCCAGGCTGGAGTGCAGTGGCATGAT
CTTGGCTCACTGCAACCTCTGCCTTCCAGGTTCAAGCAATTCTCCTGCCTCAGCCTCCCGAGTAGCTGAGATTACAGGCGCCCACCACCA
CGCCCAGCTAATTTTTGTATTTTTAGTAGAGACAGGGTTTCACCATGTTGGCCAGGCTGATCTCGAACTCCTGACCTCAGGTGACCTGCC
TTGGCCTCCCAAAGTGCAGGGATTACAAGCGTGAGCCACCATGCCCGGCCTGTCTTTTTGGTTTTGATGGGAGTCTGAGGACCCCGACCC
CTCCTGCTCTCCATCTTTGAGCCTCTGGCATCCTCTCACACCCAGAAATCAGTTGGAGTAAGTTTAATTGGCCCTGCTCCAGCTGGCCTT
TGAAGCACAAGTTTAAATCTCCACCTTCTGTGCACTGACCAGAGTCTAAAATAAAAGTTGTCAGTACCATAAAGGAAAAGGGATCCACAC
AGGTAGCCTTCTCCTTGGATACAGGTACATCTTACTGTAAGAATTTCAAGTCCTGGCTGGGCGCAGTGGCTCACTCCTGTAATCCCAGCA
CTTTGAGAGACCGAGGCAGGCAGATCACTTGAGGTCAGGAATTCAAGACCAACCTGGCCAACATGGTGAAACCCTGTCTCTAATAAAAAA
AAAATAGAAAAATCAGCCGGGTGTGGTGGCACACACCTGTAATCCTAGCTACTCAGGAGGCTGAGGCAAGAGAATCTCTTGAACCTGTGA
GCCAGAGGTTGCAGTGAGCCGAGATTCCACCACTGCACTCCAGCCTGGGCAACAGAGCAAAACTCTGTCTCAAAAAAAAAAAAAAAAAGG
CAAAATTAAAGAATTTCAAGTCCCTAATTTACTCTAACCAAGCATTTTCAGTCTTACAAAGAAATCTAGTGCACGACACCTTTAAAATGC
CTAGATTTCCATTGCCTAAAGTAAGGTGTGACCAGTGAAACAACAGCAGAGAATCATGTTCCTTTGCTGTGGAACACATAAGCCCCACAG
TTTTCCAGTCAGCCTAATACATGGGTATCCCCCGACCCCATCTGCCTCCTTAAGCCACAGTCCTTGGTGGGGAACTCTAAGGGGGACGGA
GTCAGTACCCCGGACAGGGCCACATTTGCATGAGACATGGCTGTCTCACAGGTCACAGAGCCATTACAACAGCTTACTAGTTTTTCATGG
ATTTGTTGGATTAACACCTTAAGCAGGTTTTTTATTGTTATTTTGTTTGTTTGTTTGTTTTGAGACGGGAGTTTCTCTCTTGTCTCCCAG
GCTGGAGTGCAATCGCGCAATCTCGGCTCACGGTAACCTCTGCCTCCCAGGTTCAAGCGAGTCTCCTGCCTCAGCCTTCTGAGTAGCTGG
GATTACAGGCATGCGCCACCACGCCCAACTAATTTTGTATTTTTAGTAGAGACGGGGTTTCTCCTTGTTGGTCAGGCTGGTCTCAAACCC
CGGACCTCAGGTGATCCCCCCACCTTGGCCTCCCAAAGTGCCAGGATTACAGGCATGAGCCACTGTGTCCGGTCTTGAGCAGGTTTTTAA
AATCTCCAGTGGCCATAAAACTAGCCAGGGTAGCTCATGCTTTTACTGGTTGGAATAAGGAGCCAAAACCAACAAAATAATATTTATTAG
GGCTCGATGCCCATTTCTGTGGCTAAGGCTTAGGTTTGGTGTGCAGAGCCTGGCCTGCTCTTGTGGGCTGTGGTTGCTGTGACAGTTTCG
TTTTCTGAATCTTTGTAATGCTCTTCCACCCTGCTCGTGCTGCCCAGAGGCTGATCTGCAAACCTGGGCAGTATTCCACACTGAAGCTCA
GTTTGCAAACCTTCTGCTGTGTTAATTCTGGTCAGTTTCACACAGAAGTCACGAGGGCCTCTGCCCAGGACCTTCTATTCACATTTCAAG
AATCCCTTTCTGAAATTCTCCAACTCTCTGGTCAGGAGGAGGAGCACCATTGGGGCGGGGTAGGCAGCTAGAGGCGCAGGAGCGAATCCA
GGTTCCTTGCGTGGTTCCCAGCCTCTGCTGACAGCACCTCAGCTACCAGGTGGGGAGTGGAAATTCAGCCTGCTTAGAGGACTGACCTCT
ACAGTTCATATTTGCAGTGACATAAAAGGCAAAGAGGAGCTGGCATGGTGGTACAGAAGGTATCAGTCAAGCGCAGGCTCTTCAGAAACC
TAGAAACTAAAAAGAGATGCAACATGTGACTGGCCATCAGCCAGACATGTCTAGGGTGAGACCAGTGCTCAGCACCACCCGCCAAGGAAC
ACTGATGAGTTGTGGGACATTATGGTCGGCCAAGTGAGGAATGATTGCAGGGACCAGAGAAGACCAAAGATGCCAGATGTCCCCAGAGTT
TCTTGAGGGCTGGGTTTCACGTCTTTGCTTGTCCTTTTTGTCCCCACTTGCCTGCACCGTGCCTGACTCATCCAGTGGGGAAGGTGACTC
AAGAAGTTGTTTAAGCCTAGGCCTAGGCAGTCCACTTCGGGAGGTGGGGGCACTCCACACTGGGGGGCCCTGCAGCTCCAGGGCTGGTGC
TCTAGCAGATCCGCTCAGGCACGGTTGGGTGACCGTGGGGTCACCGATTGCGTAGATTATTTCTAGGGCAGTGCTGGGTTAGAAATGTCT
GTCTGGAAACAGGACACATCTTGCCACCACAAGTCCACACCTGGCCTTGGCTGCTGCCCGCTCTCTGCAGCGTGGATTTCCTTTGCCCAT
TTGGGCCAGAAGGTCACCAGGAGTTCATCACTGCTTAGTGTCAACTTGACATCTTCAGCTTCCAGACAGAAAACCCATGCTTTACTTTGT
ACAGCCCTGTCCCAGAGTTAGTAAGCCTCGGCTTGTCACCTGCTTGCAAAGGGTATAGACATCATTCTGGGTAGTTCTAGAGGATATCGC
AACAAGTGCGTTTGAAGGTTCAGCACAGCTGGAATTGTACGGTAGTGAGCTCTTCAAAATGAAAACAGAATGACCGGATGGCCATCTGTC
CTGGAAACTGTAGAATTGAATAAATCACTGAAAATAGAACACTTCTTGGAGGCTTTCTTCAGAACTGAACTAGAAACAAGGTTTCCAGGC
TCCCAGGTCAGTAGACCAAACCAACTTCCTTAGATTTTTTTTTTTAAGCTGTTTGCAGAAAACTGGGTGGTAGCGTGTCTGAACCAAACG
GAAGAATAGCCAGCGGAGCATGGACTGTTCCAGCACGGGCCAGATGGCCAGCTGTCGAGAGCAGCCCTGCCCAGATTGCGGTGGGGGCTG
TGCCAGCGGCTCCGCAGGGCCCTTCCAACTCTGGAGTGTCTGTAGTTCTTGTGAAACCAAAACGTTGACTACCTGCCTCTTTCCTCGGGC
ATCGACGTGCTCATTTCCAAAGATGATGGTGCAGGTGACCTTTTCCATCGTGAGCTAAGAGAAGGTTAGGAGGCCTGAGGGGCGGGCCTT
GTGTCCCCTCCTCCCCCTCCACAGCCCCTGAGGTGGAGCTTCCCTCACAGACCCCATCTGGTCGAGCCTACGGCTGCCCAGTGTACACTC
AGTGATGCTTATACCAAATAGGGCATGTGCGCTGGTGTCTGTTGGGGACAGCCCCATCCCTACCTTGGAGTCGGCAGAGAAGCAGCAATA
AGCATTAGGCGAATGATTGAAAGGGCTGCTGCGCCAAGAGGCCTTCAGTCCCCTTAACGTGGCTTTCCAACTTCCTGACGAGGCTACAAA
GGCTCCGCTCACAAAAGAAAGCCAATAATGTAAATAAATAGAAAACGAAGCCTCCACGCGTGGTTTTTAAAGGGGGATGATGAATGTGAC
ACCACCCACAGAATGCATTAGAATCTGGTTTTTCTGTGCTTTGTCATTTTACTCTGATAGGAATTTTTGTTACCTAACTCTGTGCATAAC
TTATTTAATGTACTGTATAAATGAACCAAAACTGTTAAATATGTATTTAGTTTGTTCTACTTAAAGTAGTCAATAAAAAGGCTATATTCC

>78645_78645_10_RUNX1-CBFA2T2_RUNX1_chr21_36231771_ENST00000399240_CBFA2T2_chr20_32194762_ENST00000375279_length(amino acids)=761AA_BP=178
MRIPVDASTSRRFTPPSTALSPGKMSEALPLGAPDAGAALAGKLRSGDRSMVEVLADHPGELVRTDSPNFLCSVLPTHWRCNKTLPIAFK
VVALGDVPDGTLVTVMAGNDENYSAELRNATAAMKNQVARFNDLRFVGRSGRGKSFTLTITVFTNPPQVATYHRAIKITVDGPREPRIGP
EKRVPAMPGSPVEVKIQSRSSPPTMPPLPPINPGGPRPVSFTPTALSNGINHSPPTLNGAPSPPQRFSNGPASSTSSALTNQQLPATCGA
RQLSKLKRFLTTLQQFGNDISPEIGEKVRTLVLALVNSTVTIEEFHCKLQEATNFPLRPFVIPFLKANLPLLQRELLHCARAAKQTPSQY
LAQHEHLLLNTSIASPADSSELLMEVHGNGKRPSPERREENSFDRDTIAPEPPAKRVCTISPAPRHSPALTVPLMNPGGQFHPTPPPLQH
YTLEDIATSHLYREPNKMLEHREVRDRHHSLGLNGGYQDELVDHRLTEREWADEWKHLDHALNCIMEMVEKTRRSMAVLRRCQESDREEL
NYWKRRYNENTELRKTGTELVSRQHSPGSADSLSNDSQREFNSRPGTGYVPVEFWKKTEEAVNKVKIQAMSEVQKAVAEAEQKAFEVIAT
ERARMEQTIADVKRQAAEDAFLVINEQEESTENCWNCGRKASETCSGCNIARYCGSFCQHKDWERHHRLCGQNLHGQSPHGQGRPLLPVG

--------------------------------------------------------------
>78645_78645_11_RUNX1-CBFA2T2_RUNX1_chr21_36231771_ENST00000486278_CBFA2T2_chr20_32194762_ENST00000342704_length(transcript)=3406nt_BP=757nt
GAGCATCACCAACCCACAGCCAAGGCGGCGCTGGCTTTTTTTTTTTTTTTAATCTTTAACAATTTGAATATTTGTTTTTACAAAGGTAAA
AGAAATCATTGAGTCCCCCGCCTTCAGAAGAGGGTGCATTTTCAGGAGGAAGCGATGGCTTCAGACAGCATATTTGAGTCATTTCCTTCG
TACCCACAGTGCTTCATGAGAGAATGCATACTTGGAATGAATCCTTCTAGAGACGTCCACGATGCCAGCACGAGCCGCCGCTTCACGCCG
CCTTCCACCGCGCTGAGCCCAGGCAAGATGAGCGAGGCGTTGCCGCTGGGCGCCCCGGACGCCGGCGCTGCCCTGGCCGGCAAGCTGAGG
AGCGGCGACCGCAGCATGGTGGAGGTGCTGGCCGACCACCCGGGCGAGCTGGTGCGCACCGACAGCCCCAACTTCCTCTGCTCCGTGCTG
CCTACGCACTGGCGCTGCAACAAGACCCTGCCCATCGCTTTCAAGGTGGTGGCCCTAGGGGATGTTCCAGATGGCACTCTGGTCACTGTG
ATGGCTGGCAATGATGAAAACTACTCGGCTGAGCTGAGAAATGCTACCGCAGCCATGAAGAACCAGGTTGCAAGATTTAATGACCTCAGG
TTTGTCGGTCGAAGTGGAAGAGGGAAAAGCTTCACTCTGACCATCACTGTCTTCACAAACCCACCGCAAGTCGCCACCTACCACAGAGCC
ATCAAAATCACAGTGGATGGGCCCCGAGAACCTCGAATTGGTCCTGAGAAAAGGGTGCCAGCGATGCCTGGATCGCCTGTGGAAGTGAAG
ATACAGTCCAGATCCTCACCTCCCACCATGCCACCCCTCCCACCAATAAATCCTGGAGGACCGAGGCCAGTGTCCTTCACTCCTACTGCA
TTAAGCAATGGCATCAACCATTCTCCTCCTACCCTGAATGGTGCCCCATCACCGCCACAGAGATTCAGCAATGGTCCTGCCTCCTCCACA
TCATCTGCACTCACAAATCAGCAATTGCCAGCCACTTGTGGTGCTCGACAACTCAGCAAGTTGAAACGCTTTCTTACCACTCTGCAACAG
TTTGGCAATGACATCTCCCCTGAGATTGGGGAGAAGGTGCGGACTCTTGTTCTTGCACTGGTGAACTCAACAGTGACAATTGAGGAATTC
CACTGTAAGCTCCAAGAAGCCACAAACTTTCCCCTTCGTCCTTTTGTGATTCCATTTCTCAAGGCCAACCTGCCCCTGCTGCAGCGGGAA
CTGCTGCACTGCGCTCGGGCGGCCAAGCAGACCCCATCCCAGTACCTGGCTCAGCACGAACACCTTCTGCTCAACACAAGCATTGCATCG
CCTGCTGACTCGTCAGAGTTGCTCATGGAGGTGCACGGAAATGGGAAGAGGCCCAGTCCAGAGAGGAGAGAAGAGAATAGTTTTGATAGA
GACACAATTGCTCCTGAGCCTCCTGCCAAGAGAGTATGTACCATCAGCCCTGCTCCTCGGCACAGTCCTGCTCTCACTGTGCCCCTCATG
AATCCCGGGGGCCAATTCCATCCTACCCCTCCACCTCTTCAGCATTACACCTTAGAGGATATTGCAACTTCTCACCTGTATCGGGAACCC
AACAAGATGCTAGAGCATCGAGAAGTTCGTGATAGACACCACAGTCTTGGTCTAAATGGAGGCTATCAAGATGAGTTGGTAGATCATCGT
TTGACAGAAAGGGAATGGGCTGATGAATGGAAACATCTTGACCATGCGCTGAATTGCATTATGGAAATGGTAGAGAAAACAAGGCGCTCT
ATGGCAGTTCTGCGGCGCTGTCAGGAATCAGATCGTGAAGAACTCAACTACTGGAAAAGACGGTACAATGAAAACACAGAGCTGAGGAAA
ACGGGGACCGAGTTGGTCTCCAGGCAGCACAGCCCTGGGAGTGCAGATTCTCTCAGCAATGATTCTCAGAGAGAGTTCAACAGCAGGCCA
GGTACAGGATACGTACCTGTGGAGTTTTGGAAAAAAACAGAAGAAGCTGTGAATAAGGTGAAAATTCAGGCCATGTCAGAAGTACAGAAG
GCCGTCGCTGAGGCAGAGCAGAAAGCCTTTGAAGTGATTGCAACAGAGAGAGCACGAATGGAGCAAACCATAGCGGATGTCAAGCGGCAG
GCCGCAGAGGATGCTTTCCTCGTCATCAATGAGCAAGAGGAGTCCACGGAGAACTGCTGGAACTGTGGCCGCAAAGCCAGCGAGACATGC
AGTGGCTGCAATATCGCGCGATACTGTGGCTCTTTCTGCCAGCACAAGGACTGGGAGCGGCACCACCGCCTCTGTGGTCAGAACCTGCAT
GGCCAGAGCCCCCACGGCCAGGGCCGGCCGCTGCTTCCTGTAGGCAGGGGCTCCTCTGCCAGGTCCGCCGACTGCAGCGTGCCCAGCCCA
GCCCTCGACAAGACCTCGGCAACCACATCGCGTTCCTCAACACCTGCTTCTGTGACAGCTATCGACACCAACGGACTCTGAGCCCCGGAC
TCTGCTTACCCTGATGGCTGCTCAGCACCACAGAGTGCTTGGGCTGAGGGACTGACTGTTGGAACCCGTGCATGTAGCTGCCGGGTCATC
AGCAAGAAATGAATTGGAGGCAGGAAGAGTCCAAGCCTGAATAATAACACCCCACAGCCTCTCTGTGCACTTGCTGTCTGCGGAGCCAGT
GTGCCATTCTCTGCACATGGGCAGCCAGCCTGAGCTGCCTCCTCCATGGCTTTCCTGGTTTGTTCCTCTCTCCACTGAAGCTGACTTAGC
CGGCCCCTTTTCAGTGTAGACCACCAGCTCCCCTCCCCATCTCCTTGAGTCAGCAGACTGTCCAATGTGCTCAGCCAGGCTGGAGGCGGC
AGGCGGCAGGCAGCAGGCTGTGGAGGAGGCCCCTCGGTCAGGGAGCGGCCTGCCTCACCCCTGAATAGCTCCTTCGGCCCCATCTCCATC
CTCAGCAGATGACACTGATTGGCCTCACGGGGACTTGGGTAAGCAACAGGCGGCATTCAGGACTCTTCTCAACCCTGCTGTTCAGACTTG
ATAAGATCTCAGAGTCCACAGGAAAGAAGTCACTGTTGCAATAAAAGCACCCGTAGTAGCAAAAACATAAAACAAATAAAACTTCCCCCA
CATCACAGATGATTTTGGACAAGATTTTCCAACCTTGCTGGCTACTTTAGTTTGGGACCTGTTTTTTTTCTCATTTGATTTTGCTTGTGC
AGAAAATAGTTTCCAGCACATGGATTGATCTGAGAGAGAATGAGGCTCAGTTGTGGATAGTCTGTTTTCTCTGAGCATGTTGGCCAACTA

>78645_78645_11_RUNX1-CBFA2T2_RUNX1_chr21_36231771_ENST00000486278_CBFA2T2_chr20_32194762_ENST00000342704_length(amino acids)=788AA_BP=205
MASDSIFESFPSYPQCFMRECILGMNPSRDVHDASTSRRFTPPSTALSPGKMSEALPLGAPDAGAALAGKLRSGDRSMVEVLADHPGELV
RTDSPNFLCSVLPTHWRCNKTLPIAFKVVALGDVPDGTLVTVMAGNDENYSAELRNATAAMKNQVARFNDLRFVGRSGRGKSFTLTITVF
TNPPQVATYHRAIKITVDGPREPRIGPEKRVPAMPGSPVEVKIQSRSSPPTMPPLPPINPGGPRPVSFTPTALSNGINHSPPTLNGAPSP
PQRFSNGPASSTSSALTNQQLPATCGARQLSKLKRFLTTLQQFGNDISPEIGEKVRTLVLALVNSTVTIEEFHCKLQEATNFPLRPFVIP
FLKANLPLLQRELLHCARAAKQTPSQYLAQHEHLLLNTSIASPADSSELLMEVHGNGKRPSPERREENSFDRDTIAPEPPAKRVCTISPA
PRHSPALTVPLMNPGGQFHPTPPPLQHYTLEDIATSHLYREPNKMLEHREVRDRHHSLGLNGGYQDELVDHRLTEREWADEWKHLDHALN
CIMEMVEKTRRSMAVLRRCQESDREELNYWKRRYNENTELRKTGTELVSRQHSPGSADSLSNDSQREFNSRPGTGYVPVEFWKKTEEAVN
KVKIQAMSEVQKAVAEAEQKAFEVIATERARMEQTIADVKRQAAEDAFLVINEQEESTENCWNCGRKASETCSGCNIARYCGSFCQHKDW

--------------------------------------------------------------
>78645_78645_12_RUNX1-CBFA2T2_RUNX1_chr21_36231771_ENST00000486278_CBFA2T2_chr20_32194762_ENST00000375279_length(transcript)=7901nt_BP=757nt
GAGCATCACCAACCCACAGCCAAGGCGGCGCTGGCTTTTTTTTTTTTTTTAATCTTTAACAATTTGAATATTTGTTTTTACAAAGGTAAA
AGAAATCATTGAGTCCCCCGCCTTCAGAAGAGGGTGCATTTTCAGGAGGAAGCGATGGCTTCAGACAGCATATTTGAGTCATTTCCTTCG
TACCCACAGTGCTTCATGAGAGAATGCATACTTGGAATGAATCCTTCTAGAGACGTCCACGATGCCAGCACGAGCCGCCGCTTCACGCCG
CCTTCCACCGCGCTGAGCCCAGGCAAGATGAGCGAGGCGTTGCCGCTGGGCGCCCCGGACGCCGGCGCTGCCCTGGCCGGCAAGCTGAGG
AGCGGCGACCGCAGCATGGTGGAGGTGCTGGCCGACCACCCGGGCGAGCTGGTGCGCACCGACAGCCCCAACTTCCTCTGCTCCGTGCTG
CCTACGCACTGGCGCTGCAACAAGACCCTGCCCATCGCTTTCAAGGTGGTGGCCCTAGGGGATGTTCCAGATGGCACTCTGGTCACTGTG
ATGGCTGGCAATGATGAAAACTACTCGGCTGAGCTGAGAAATGCTACCGCAGCCATGAAGAACCAGGTTGCAAGATTTAATGACCTCAGG
TTTGTCGGTCGAAGTGGAAGAGGGAAAAGCTTCACTCTGACCATCACTGTCTTCACAAACCCACCGCAAGTCGCCACCTACCACAGAGCC
ATCAAAATCACAGTGGATGGGCCCCGAGAACCTCGAATTGGTCCTGAGAAAAGGGTGCCAGCGATGCCTGGATCGCCTGTGGAAGTGAAG
ATACAGTCCAGATCCTCACCTCCCACCATGCCACCCCTCCCACCAATAAATCCTGGAGGACCGAGGCCAGTGTCCTTCACTCCTACTGCA
TTAAGCAATGGCATCAACCATTCTCCTCCTACCCTGAATGGTGCCCCATCACCGCCACAGAGATTCAGCAATGGTCCTGCCTCCTCCACA
TCATCTGCACTCACAAATCAGCAATTGCCAGCCACTTGTGGTGCTCGACAACTCAGCAAGTTGAAACGCTTTCTTACCACTCTGCAACAG
TTTGGCAATGACATCTCCCCTGAGATTGGGGAGAAGGTGCGGACTCTTGTTCTTGCACTGGTGAACTCAACAGTGACAATTGAGGAATTC
CACTGTAAGCTCCAAGAAGCCACAAACTTTCCCCTTCGTCCTTTTGTGATTCCATTTCTCAAGGCCAACCTGCCCCTGCTGCAGCGGGAA
CTGCTGCACTGCGCTCGGGCGGCCAAGCAGACCCCATCCCAGTACCTGGCTCAGCACGAACACCTTCTGCTCAACACAAGCATTGCATCG
CCTGCTGACTCGTCAGAGTTGCTCATGGAGGTGCACGGAAATGGGAAGAGGCCCAGTCCAGAGAGGAGAGAAGAGAATAGTTTTGATAGA
GACACAATTGCTCCTGAGCCTCCTGCCAAGAGAGTATGTACCATCAGCCCTGCTCCTCGGCACAGTCCTGCTCTCACTGTGCCCCTCATG
AATCCCGGGGGCCAATTCCATCCTACCCCTCCACCTCTTCAGCATTACACCTTAGAGGATATTGCAACTTCTCACCTGTATCGGGAACCC
AACAAGATGCTAGAGCATCGAGAAGTTCGTGATAGACACCACAGTCTTGGTCTAAATGGAGGCTATCAAGATGAGTTGGTAGATCATCGT
TTGACAGAAAGGGAATGGGCTGATGAATGGAAACATCTTGACCATGCGCTGAATTGCATTATGGAAATGGTAGAGAAAACAAGGCGCTCT
ATGGCAGTTCTGCGGCGCTGTCAGGAATCAGATCGTGAAGAACTCAACTACTGGAAAAGACGGTACAATGAAAACACAGAGCTGAGGAAA
ACGGGGACCGAGTTGGTCTCCAGGCAGCACAGCCCTGGGAGTGCAGATTCTCTCAGCAATGATTCTCAGAGAGAGTTCAACAGCAGGCCA
GGTACAGGATACGTACCTGTGGAGTTTTGGAAAAAAACAGAAGAAGCTGTGAATAAGGTGAAAATTCAGGCCATGTCAGAAGTACAGAAG
GCCGTCGCTGAGGCAGAGCAGAAAGCCTTTGAAGTGATTGCAACAGAGAGAGCACGAATGGAGCAAACCATAGCGGATGTCAAGCGGCAG
GCCGCAGAGGATGCTTTCCTCGTCATCAATGAGCAAGAGGAGTCCACGGAGAACTGCTGGAACTGTGGCCGCAAAGCCAGCGAGACATGC
AGTGGCTGCAATATCGCGCGATACTGTGGCTCTTTCTGCCAGCACAAGGACTGGGAGCGGCACCACCGCCTCTGTGGTCAGAACCTGCAT
GGCCAGAGCCCCCACGGCCAGGGCCGGCCGCTGCTTCCTGTAGGCAGGGGCTCCTCTGCCAGGTCCGCCGACTGCAGCGTGCCCAGCCCA
GCCCTCGACAAGACCTCGGCAACCACATCGCGTTCCTCAACACCTGCTTCTGTGACAGCTATCGACACCAACGGACTCTGAGCCCCGGAC
TCTGCTTACCCTGATGGCTGCTCAGCACCACAGAGTGCTTGGGCTGAGGGACTGACTGTTGGAACCCGTGCATGTAGCTGCCGGGTCATC
AGCAAGAAATGAATTGGAGGCAGGAAGAGTCCAAGCCTGAATAATAACACCCCACAGCCTCTCTGTGCACTTGCTGTCTGCGGAGCCAGT
GTGCCATTCTCTGCACATGGGCAGCCAGCCTGAGCTGCCTCCTCCATGGCTTTCCTGGTTTGTTCCTCTCTCCACTGAAGCTGACTTAGC
CGGCCCCTTTTCAGTGTAGACCACCAGCTCCCCTCCCCATCTCCTTGAGTCAGCAGACTGTCCAATGTGCTCAGCCAGGCTGGAGGCGGC
AGGCGGCAGGCAGCAGGCTGTGGAGGAGGCCCCTCGGTCAGGGAGCGGCCTGCCTCACCCCTGAATAGCTCCTTCGGCCCCATCTCCATC
CTCAGCAGATGACACTGATTGGCCTCACGGGGACTTGGGTAAGCAACAGGCGGCATTCAGGACTCTTCTCAACCCTGCTGTTCAGACTTG
ATAAGATCTCAGAGTCCACAGGAAAGAAGTCACTGTTGCAATAAAAGCACCCGTAGTAGCAAAAACATAAAACAAATAAAACTTCCCCCA
CATCACAGATGATTTTGGACAAGATTTTCCAACCTTGCTGGCTACTTTAGTTTGGGACCTGTTTTTTTTCTCATTTGATTTTGCTTGTGC
AGAAAATAGTTTCCAGCACATGGATTGATCTGAGAGAGAATGAGGCTCAGTTGTGGATAGTCTGTTTTCTCTGAGCATGTTGGCCAACTA
GTATCGTCAAATTATTGAGTGGATCATCTCTTGGAAATGCAGAACTTCTGCCACCACTTGGCTATTTGCACAGTCATCTTGTTCTGTGTC
CTTTTATCTCTCAGACCACACACATCTGGAACGCTGTGGGCATCTTCTGCCCATGGGCTCCATTTGGCACCTGCTGAGCCACAGTTGTCC
TGCTGGATGTGCTGTGCAGGTTGGTAGGACTTGCCCCCACTGTCAAGGCCTGGTCTCATCTGAAAAGCCCTCCTGGACCTCAAAGAATTC
TTCAGACCTCATAGTTACAGGTCATTATATCTACTATGTTGATTTATCATCAGGCACACAACTTCTGTTTCCTTCTCTTGTGTTATCTGA
TAGCGTCCCTCCTTGAGCTCATCAGAAAGGTTTTATGAAATGTGAACCATTTTGGGAAAAGCTGATCAATTTTTCTTCCTAGCTTCCCAT
TTTCAAATGGGACATCACTCATATCCCTTTCAGAATGTTAGGAACTGCCTCCCACATTCTTCCCTGTCTTTTTGGGTTTTGTTTTTTGTT
GTTGTGGTGGTTTTTTAACACAAAGTCTCACTCTGTTGCCCAGGCTGGAGTGCAGTGGCATGATCTTGGCTCACTGCAACCTCTGCCTTC
CAGGTTCAAGCAATTCTCCTGCCTCAGCCTCCCGAGTAGCTGAGATTACAGGCGCCCACCACCACGCCCAGCTAATTTTTGTATTTTTAG
TAGAGACAGGGTTTCACCATGTTGGCCAGGCTGATCTCGAACTCCTGACCTCAGGTGACCTGCCTTGGCCTCCCAAAGTGCAGGGATTAC
AAGCGTGAGCCACCATGCCCGGCCTGTCTTTTTGGTTTTGATGGGAGTCTGAGGACCCCGACCCCTCCTGCTCTCCATCTTTGAGCCTCT
GGCATCCTCTCACACCCAGAAATCAGTTGGAGTAAGTTTAATTGGCCCTGCTCCAGCTGGCCTTTGAAGCACAAGTTTAAATCTCCACCT
TCTGTGCACTGACCAGAGTCTAAAATAAAAGTTGTCAGTACCATAAAGGAAAAGGGATCCACACAGGTAGCCTTCTCCTTGGATACAGGT
ACATCTTACTGTAAGAATTTCAAGTCCTGGCTGGGCGCAGTGGCTCACTCCTGTAATCCCAGCACTTTGAGAGACCGAGGCAGGCAGATC
ACTTGAGGTCAGGAATTCAAGACCAACCTGGCCAACATGGTGAAACCCTGTCTCTAATAAAAAAAAAATAGAAAAATCAGCCGGGTGTGG
TGGCACACACCTGTAATCCTAGCTACTCAGGAGGCTGAGGCAAGAGAATCTCTTGAACCTGTGAGCCAGAGGTTGCAGTGAGCCGAGATT
CCACCACTGCACTCCAGCCTGGGCAACAGAGCAAAACTCTGTCTCAAAAAAAAAAAAAAAAAGGCAAAATTAAAGAATTTCAAGTCCCTA
ATTTACTCTAACCAAGCATTTTCAGTCTTACAAAGAAATCTAGTGCACGACACCTTTAAAATGCCTAGATTTCCATTGCCTAAAGTAAGG
TGTGACCAGTGAAACAACAGCAGAGAATCATGTTCCTTTGCTGTGGAACACATAAGCCCCACAGTTTTCCAGTCAGCCTAATACATGGGT
ATCCCCCGACCCCATCTGCCTCCTTAAGCCACAGTCCTTGGTGGGGAACTCTAAGGGGGACGGAGTCAGTACCCCGGACAGGGCCACATT
TGCATGAGACATGGCTGTCTCACAGGTCACAGAGCCATTACAACAGCTTACTAGTTTTTCATGGATTTGTTGGATTAACACCTTAAGCAG
GTTTTTTATTGTTATTTTGTTTGTTTGTTTGTTTTGAGACGGGAGTTTCTCTCTTGTCTCCCAGGCTGGAGTGCAATCGCGCAATCTCGG
CTCACGGTAACCTCTGCCTCCCAGGTTCAAGCGAGTCTCCTGCCTCAGCCTTCTGAGTAGCTGGGATTACAGGCATGCGCCACCACGCCC
AACTAATTTTGTATTTTTAGTAGAGACGGGGTTTCTCCTTGTTGGTCAGGCTGGTCTCAAACCCCGGACCTCAGGTGATCCCCCCACCTT
GGCCTCCCAAAGTGCCAGGATTACAGGCATGAGCCACTGTGTCCGGTCTTGAGCAGGTTTTTAAAATCTCCAGTGGCCATAAAACTAGCC
AGGGTAGCTCATGCTTTTACTGGTTGGAATAAGGAGCCAAAACCAACAAAATAATATTTATTAGGGCTCGATGCCCATTTCTGTGGCTAA
GGCTTAGGTTTGGTGTGCAGAGCCTGGCCTGCTCTTGTGGGCTGTGGTTGCTGTGACAGTTTCGTTTTCTGAATCTTTGTAATGCTCTTC
CACCCTGCTCGTGCTGCCCAGAGGCTGATCTGCAAACCTGGGCAGTATTCCACACTGAAGCTCAGTTTGCAAACCTTCTGCTGTGTTAAT
TCTGGTCAGTTTCACACAGAAGTCACGAGGGCCTCTGCCCAGGACCTTCTATTCACATTTCAAGAATCCCTTTCTGAAATTCTCCAACTC
TCTGGTCAGGAGGAGGAGCACCATTGGGGCGGGGTAGGCAGCTAGAGGCGCAGGAGCGAATCCAGGTTCCTTGCGTGGTTCCCAGCCTCT
GCTGACAGCACCTCAGCTACCAGGTGGGGAGTGGAAATTCAGCCTGCTTAGAGGACTGACCTCTACAGTTCATATTTGCAGTGACATAAA
AGGCAAAGAGGAGCTGGCATGGTGGTACAGAAGGTATCAGTCAAGCGCAGGCTCTTCAGAAACCTAGAAACTAAAAAGAGATGCAACATG
TGACTGGCCATCAGCCAGACATGTCTAGGGTGAGACCAGTGCTCAGCACCACCCGCCAAGGAACACTGATGAGTTGTGGGACATTATGGT
CGGCCAAGTGAGGAATGATTGCAGGGACCAGAGAAGACCAAAGATGCCAGATGTCCCCAGAGTTTCTTGAGGGCTGGGTTTCACGTCTTT
GCTTGTCCTTTTTGTCCCCACTTGCCTGCACCGTGCCTGACTCATCCAGTGGGGAAGGTGACTCAAGAAGTTGTTTAAGCCTAGGCCTAG
GCAGTCCACTTCGGGAGGTGGGGGCACTCCACACTGGGGGGCCCTGCAGCTCCAGGGCTGGTGCTCTAGCAGATCCGCTCAGGCACGGTT
GGGTGACCGTGGGGTCACCGATTGCGTAGATTATTTCTAGGGCAGTGCTGGGTTAGAAATGTCTGTCTGGAAACAGGACACATCTTGCCA
CCACAAGTCCACACCTGGCCTTGGCTGCTGCCCGCTCTCTGCAGCGTGGATTTCCTTTGCCCATTTGGGCCAGAAGGTCACCAGGAGTTC
ATCACTGCTTAGTGTCAACTTGACATCTTCAGCTTCCAGACAGAAAACCCATGCTTTACTTTGTACAGCCCTGTCCCAGAGTTAGTAAGC
CTCGGCTTGTCACCTGCTTGCAAAGGGTATAGACATCATTCTGGGTAGTTCTAGAGGATATCGCAACAAGTGCGTTTGAAGGTTCAGCAC
AGCTGGAATTGTACGGTAGTGAGCTCTTCAAAATGAAAACAGAATGACCGGATGGCCATCTGTCCTGGAAACTGTAGAATTGAATAAATC
ACTGAAAATAGAACACTTCTTGGAGGCTTTCTTCAGAACTGAACTAGAAACAAGGTTTCCAGGCTCCCAGGTCAGTAGACCAAACCAACT
TCCTTAGATTTTTTTTTTTAAGCTGTTTGCAGAAAACTGGGTGGTAGCGTGTCTGAACCAAACGGAAGAATAGCCAGCGGAGCATGGACT
GTTCCAGCACGGGCCAGATGGCCAGCTGTCGAGAGCAGCCCTGCCCAGATTGCGGTGGGGGCTGTGCCAGCGGCTCCGCAGGGCCCTTCC
AACTCTGGAGTGTCTGTAGTTCTTGTGAAACCAAAACGTTGACTACCTGCCTCTTTCCTCGGGCATCGACGTGCTCATTTCCAAAGATGA
TGGTGCAGGTGACCTTTTCCATCGTGAGCTAAGAGAAGGTTAGGAGGCCTGAGGGGCGGGCCTTGTGTCCCCTCCTCCCCCTCCACAGCC
CCTGAGGTGGAGCTTCCCTCACAGACCCCATCTGGTCGAGCCTACGGCTGCCCAGTGTACACTCAGTGATGCTTATACCAAATAGGGCAT
GTGCGCTGGTGTCTGTTGGGGACAGCCCCATCCCTACCTTGGAGTCGGCAGAGAAGCAGCAATAAGCATTAGGCGAATGATTGAAAGGGC
TGCTGCGCCAAGAGGCCTTCAGTCCCCTTAACGTGGCTTTCCAACTTCCTGACGAGGCTACAAAGGCTCCGCTCACAAAAGAAAGCCAAT
AATGTAAATAAATAGAAAACGAAGCCTCCACGCGTGGTTTTTAAAGGGGGATGATGAATGTGACACCACCCACAGAATGCATTAGAATCT
GGTTTTTCTGTGCTTTGTCATTTTACTCTGATAGGAATTTTTGTTACCTAACTCTGTGCATAACTTATTTAATGTACTGTATAAATGAAC

>78645_78645_12_RUNX1-CBFA2T2_RUNX1_chr21_36231771_ENST00000486278_CBFA2T2_chr20_32194762_ENST00000375279_length(amino acids)=788AA_BP=205
MASDSIFESFPSYPQCFMRECILGMNPSRDVHDASTSRRFTPPSTALSPGKMSEALPLGAPDAGAALAGKLRSGDRSMVEVLADHPGELV
RTDSPNFLCSVLPTHWRCNKTLPIAFKVVALGDVPDGTLVTVMAGNDENYSAELRNATAAMKNQVARFNDLRFVGRSGRGKSFTLTITVF
TNPPQVATYHRAIKITVDGPREPRIGPEKRVPAMPGSPVEVKIQSRSSPPTMPPLPPINPGGPRPVSFTPTALSNGINHSPPTLNGAPSP
PQRFSNGPASSTSSALTNQQLPATCGARQLSKLKRFLTTLQQFGNDISPEIGEKVRTLVLALVNSTVTIEEFHCKLQEATNFPLRPFVIP
FLKANLPLLQRELLHCARAAKQTPSQYLAQHEHLLLNTSIASPADSSELLMEVHGNGKRPSPERREENSFDRDTIAPEPPAKRVCTISPA
PRHSPALTVPLMNPGGQFHPTPPPLQHYTLEDIATSHLYREPNKMLEHREVRDRHHSLGLNGGYQDELVDHRLTEREWADEWKHLDHALN
CIMEMVEKTRRSMAVLRRCQESDREELNYWKRRYNENTELRKTGTELVSRQHSPGSADSLSNDSQREFNSRPGTGYVPVEFWKKTEEAVN
KVKIQAMSEVQKAVAEAEQKAFEVIATERARMEQTIADVKRQAAEDAFLVINEQEESTENCWNCGRKASETCSGCNIARYCGSFCQHKDW

--------------------------------------------------------------

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Fusion Gene PPI Analysis for RUNX1-CBFA2T2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
HgeneRUNX1chr21:36231771chr20:32194762ENST00000300305-58135_143204.33333333333334481.0DNA
HgeneRUNX1chr21:36231771chr20:32194762ENST00000300305-58168_177204.33333333333334481.0DNA
HgeneRUNX1chr21:36231771chr20:32194762ENST00000300305-5880_84204.33333333333334481.0DNA
HgeneRUNX1chr21:36231771chr20:32194762ENST00000325074-47135_143192.33333333333334469.0DNA
HgeneRUNX1chr21:36231771chr20:32194762ENST00000325074-47168_177192.33333333333334469.0DNA
HgeneRUNX1chr21:36231771chr20:32194762ENST00000325074-4780_84192.33333333333334469.0DNA
HgeneRUNX1chr21:36231771chr20:32194762ENST00000344691-36135_143177.33333333333334454.0DNA
HgeneRUNX1chr21:36231771chr20:32194762ENST00000344691-36168_177177.33333333333334454.0DNA
HgeneRUNX1chr21:36231771chr20:32194762ENST00000344691-3680_84177.33333333333334454.0DNA
HgeneRUNX1chr21:36231771chr20:32194762ENST00000358356-35135_143177.33333333333334251.0DNA
HgeneRUNX1chr21:36231771chr20:32194762ENST00000358356-35168_177177.33333333333334251.0DNA
HgeneRUNX1chr21:36231771chr20:32194762ENST00000358356-3580_84177.33333333333334251.0DNA
HgeneRUNX1chr21:36231771chr20:32194762ENST00000437180-69135_143204.33333333333334481.0DNA
HgeneRUNX1chr21:36231771chr20:32194762ENST00000437180-69168_177204.33333333333334481.0DNA
HgeneRUNX1chr21:36231771chr20:32194762ENST00000437180-6980_84204.33333333333334481.0DNA
TgeneCBFA2T2chr21:36231771chr20:32194762ENST00000342704011107_21511.333333333333334596.0PRDM14
TgeneCBFA2T2chr21:36231771chr20:32194762ENST0000034420106107_2150264.0PRDM14
TgeneCBFA2T2chr21:36231771chr20:32194762ENST00000346541112107_21520.333333333333332605.0PRDM14
TgeneCBFA2T2chr21:36231771chr20:32194762ENST00000359606011107_21530.333333333333332615.0PRDM14
TgeneCBFA2T2chr21:36231771chr20:32194762ENST00000375279112107_21520.333333333333332605.0PRDM14
TgeneCBFA2T2chr21:36231771chr20:32194762ENST0000039779817107_2150264.0PRDM14
TgeneCBFA2T2chr21:36231771chr20:32194762ENST00000397800011107_2150576.0PRDM14
TgeneCBFA2T2chr21:36231771chr20:32194762ENST00000492345213107_2150576.0PRDM14


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneRUNX1chr21:36231771chr20:32194762ENST00000300305-58362_402204.33333333333334481.0FOXP3
HgeneRUNX1chr21:36231771chr20:32194762ENST00000325074-47362_402192.33333333333334469.0FOXP3
HgeneRUNX1chr21:36231771chr20:32194762ENST00000344691-36362_402177.33333333333334454.0FOXP3
HgeneRUNX1chr21:36231771chr20:32194762ENST00000358356-35362_402177.33333333333334251.0FOXP3
HgeneRUNX1chr21:36231771chr20:32194762ENST00000437180-69362_402204.33333333333334481.0FOXP3
HgeneRUNX1chr21:36231771chr20:32194762ENST00000300305-58291_371204.33333333333334481.0KAT6A
HgeneRUNX1chr21:36231771chr20:32194762ENST00000325074-47291_371192.33333333333334469.0KAT6A
HgeneRUNX1chr21:36231771chr20:32194762ENST00000344691-36291_371177.33333333333334454.0KAT6A
HgeneRUNX1chr21:36231771chr20:32194762ENST00000358356-35291_371177.33333333333334251.0KAT6A
HgeneRUNX1chr21:36231771chr20:32194762ENST00000437180-69291_371204.33333333333334481.0KAT6A
HgeneRUNX1chr21:36231771chr20:32194762ENST00000300305-58307_400204.33333333333334481.0KAT6B
HgeneRUNX1chr21:36231771chr20:32194762ENST00000325074-47307_400192.33333333333334469.0KAT6B
HgeneRUNX1chr21:36231771chr20:32194762ENST00000344691-36307_400177.33333333333334454.0KAT6B
HgeneRUNX1chr21:36231771chr20:32194762ENST00000358356-35307_400177.33333333333334251.0KAT6B
HgeneRUNX1chr21:36231771chr20:32194762ENST00000437180-69307_400204.33333333333334481.0KAT6B


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for RUNX1-CBFA2T2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for RUNX1-CBFA2T2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource