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 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:RUNX1-USP42 (FusionGDB2 ID:78697) |
Fusion Gene Summary for RUNX1-USP42 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: RUNX1-USP42 | Fusion gene ID: 78697 | Hgene | Tgene | Gene symbol | RUNX1 | USP42 | Gene ID | 861 | 84132 |
| Gene name | RUNX family transcription factor 1 | ubiquitin specific peptidase 42 | |
| Synonyms | AML1|AML1-EVI-1|AMLCR1|CBF2alpha|CBFA2|EVI-1|PEBP2aB|PEBP2alpha | - | |
| Cytomap | 21q22.12 | 7p22.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | runt-related transcription factor 1AML1-EVI-1 fusion proteinPEA2-alpha BPEBP2-alpha BSL3-3 enhancer factor 1 alpha B subunitSL3/AKV core-binding factor alpha B subunitacute myeloid leukemia 1 proteincore-binding factor, runt domain, alpha subunit 2 | ubiquitin carboxyl-terminal hydrolase 42deubiquitinating enzyme 42ubiquitin specific protease 42ubiquitin thioesterase 42ubiquitin thiolesterase 42ubiquitin-specific-processing protease 42 | |
| Modification date | 20200322 | 20200320 | |
| UniProtAcc | . | Q9H9J4 | |
| Ensembl transtripts involved in fusion gene | ENST00000437180, ENST00000300305, ENST00000325074, ENST00000344691, ENST00000399240, ENST00000358356, ENST00000486278, ENST00000494829, | ENST00000306177, | |
| Fusion gene scores | * DoF score | 46 X 68 X 13=40664 | 6 X 8 X 7=336 |
| # samples | 89 | 8 | |
| ** MAII score | log2(89/40664*10)=-5.51380298959468 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(8/336*10)=-2.0703893278914 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: RUNX1 [Title/Abstract] AND USP42 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | RUNX1(36167758)-USP42(6150914), # samples:1 RUNX1(36167489)-USP42(6150914), # samples:1 USP42(6151080)-RUNX1(36167584), # samples:1 | ||
| Anticipated loss of major functional domain due to fusion event. | RUNX1-USP42 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF. RUNX1-USP42 seems lost the major protein functional domain in Hgene partner, which is a transcription factor due to the frame-shifted ORF. RUNX1-USP42 seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF. RUNX1-USP42 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | RUNX1 | GO:0030097 | hemopoiesis | 21873977 |
| Hgene | RUNX1 | GO:0045893 | positive regulation of transcription, DNA-templated | 10207087|14970218 |
| Hgene | RUNX1 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 9199349|10207087|14970218|21873977 |
| Tgene | USP42 | GO:0016579 | protein deubiquitination | 14715245 |
| Fusion gene breakpoints across RUNX1 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
| Fusion gene breakpoints across USP42 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | acute myeloid leukemia | FR727326 | RUNX1 | chr21 | 36167758 | USP42 | chr7 | 6150914 | ||
| ChimerKB3 | . | . | RUNX1 | chr21 | 36171597 | - | USP42 | chr7 | 6154953 | + |
| ChiTaRS5.0 | N/A | FR727326 | RUNX1 | chr21 | 36167489 | - | USP42 | chr7 | 6150914 | + |
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Fusion Gene ORF analysis for RUNX1-USP42 |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000437180 | ENST00000306177 | RUNX1 | chr21 | 36171597 | - | USP42 | chr7 | 6154953 | + |
| In-frame | ENST00000300305 | ENST00000306177 | RUNX1 | chr21 | 36171597 | - | USP42 | chr7 | 6154953 | + |
| In-frame | ENST00000325074 | ENST00000306177 | RUNX1 | chr21 | 36171597 | - | USP42 | chr7 | 6154953 | + |
| In-frame | ENST00000344691 | ENST00000306177 | RUNX1 | chr21 | 36171597 | - | USP42 | chr7 | 6154953 | + |
| In-frame | ENST00000399240 | ENST00000306177 | RUNX1 | chr21 | 36171597 | - | USP42 | chr7 | 6154953 | + |
| intron-3CDS | ENST00000300305 | ENST00000306177 | RUNX1 | chr21 | 36167758 | USP42 | chr7 | 6150914 | ||
| intron-3CDS | ENST00000300305 | ENST00000306177 | RUNX1 | chr21 | 36167489 | - | USP42 | chr7 | 6150914 | + |
| intron-3CDS | ENST00000325074 | ENST00000306177 | RUNX1 | chr21 | 36167758 | USP42 | chr7 | 6150914 | ||
| intron-3CDS | ENST00000325074 | ENST00000306177 | RUNX1 | chr21 | 36167489 | - | USP42 | chr7 | 6150914 | + |
| intron-3CDS | ENST00000344691 | ENST00000306177 | RUNX1 | chr21 | 36167758 | USP42 | chr7 | 6150914 | ||
| intron-3CDS | ENST00000344691 | ENST00000306177 | RUNX1 | chr21 | 36167489 | - | USP42 | chr7 | 6150914 | + |
| intron-3CDS | ENST00000358356 | ENST00000306177 | RUNX1 | chr21 | 36167758 | USP42 | chr7 | 6150914 | ||
| intron-3CDS | ENST00000358356 | ENST00000306177 | RUNX1 | chr21 | 36171597 | - | USP42 | chr7 | 6154953 | + |
| intron-3CDS | ENST00000358356 | ENST00000306177 | RUNX1 | chr21 | 36167489 | - | USP42 | chr7 | 6150914 | + |
| intron-3CDS | ENST00000399240 | ENST00000306177 | RUNX1 | chr21 | 36167758 | USP42 | chr7 | 6150914 | ||
| intron-3CDS | ENST00000399240 | ENST00000306177 | RUNX1 | chr21 | 36167489 | - | USP42 | chr7 | 6150914 | + |
| intron-3CDS | ENST00000437180 | ENST00000306177 | RUNX1 | chr21 | 36167758 | USP42 | chr7 | 6150914 | ||
| intron-3CDS | ENST00000437180 | ENST00000306177 | RUNX1 | chr21 | 36167489 | - | USP42 | chr7 | 6150914 | + |
| intron-3CDS | ENST00000486278 | ENST00000306177 | RUNX1 | chr21 | 36167758 | USP42 | chr7 | 6150914 | ||
| intron-3CDS | ENST00000486278 | ENST00000306177 | RUNX1 | chr21 | 36171597 | - | USP42 | chr7 | 6154953 | + |
| intron-3CDS | ENST00000486278 | ENST00000306177 | RUNX1 | chr21 | 36167489 | - | USP42 | chr7 | 6150914 | + |
| intron-3CDS | ENST00000494829 | ENST00000306177 | RUNX1 | chr21 | 36167758 | USP42 | chr7 | 6150914 | ||
| intron-3CDS | ENST00000494829 | ENST00000306177 | RUNX1 | chr21 | 36171597 | - | USP42 | chr7 | 6154953 | + |
| intron-3CDS | ENST00000494829 | ENST00000306177 | RUNX1 | chr21 | 36167489 | - | USP42 | chr7 | 6150914 | + |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000344691 | RUNX1 | chr21 | 36171597 | - | ENST00000306177 | USP42 | chr7 | 6154953 | + | 7220 | 2464 | 1578 | 6173 | 1531 |
| ENST00000325074 | RUNX1 | chr21 | 36171597 | - | ENST00000306177 | USP42 | chr7 | 6154953 | + | 5687 | 931 | 0 | 4640 | 1546 |
| ENST00000300305 | RUNX1 | chr21 | 36171597 | - | ENST00000306177 | USP42 | chr7 | 6154953 | + | 6168 | 1412 | 445 | 5121 | 1558 |
| ENST00000399240 | RUNX1 | chr21 | 36171597 | - | ENST00000306177 | USP42 | chr7 | 6154953 | + | 5521 | 765 | 71 | 4474 | 1467 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
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Fusion Genomic Features for RUNX1-USP42 |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for RUNX1-USP42 |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr21:36167758/chr7:6150914) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| . | USP42 |
| FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. | FUNCTION: Deubiquitinating enzyme which may play an important role during spermatogenesis. {ECO:0000250}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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Fusion Gene Sequence for RUNX1-USP42 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >78697_78697_1_RUNX1-USP42_RUNX1_chr21_36171597_ENST00000300305_USP42_chr7_6154953_ENST00000306177_length(transcript)=6168nt_BP=1412nt GGAAAGGGGAACAGTTAAATTTGTAATTTGGGTTGTGTGAAAACTTCTTTGGGCCTCATAAACAACCACAGAACCACAAGTTGGGTAGCC TGGCAGTGTCAGAAGTCTGAACCCAGCATAGTGGTCAGCAGGCAGGACGAATCACACTGAATGCAAACCACAGGGTTTCGCAGCGTGGTG AGCATCACCAACCCACAGCCAAGGCGGCGCTGGCTTTTTTTTTTTTTTTAATCTTTAACAATTTGAATATTTGTTTTTACAAAGGTGCAT TTTTTAATAGGGCTTGGGGAGTCCCAGAGGTATCCAGCAGAGGGGAGAAGAAAGAGAGATGTAGGGCTAGAGGGGTGAGGCTGAAACAGT GACCTGTCTTGGTTTTCGCTCCGAAGGTAAAAGAAATCATTGAGTCCCCCGCCTTCAGAAGAGGGTGCATTTTCAGGAGGAAGCGATGGC TTCAGACAGCATATTTGAGTCATTTCCTTCGTACCCACAGTGCTTCATGAGAGAATGCATACTTGGAATGAATCCTTCTAGAGACGTCCA CGATGCCAGCACGAGCCGCCGCTTCACGCCGCCTTCCACCGCGCTGAGCCCAGGCAAGATGAGCGAGGCGTTGCCGCTGGGCGCCCCGGA CGCCGGCGCTGCCCTGGCCGGCAAGCTGAGGAGCGGCGACCGCAGCATGGTGGAGGTGCTGGCCGACCACCCGGGCGAGCTGGTGCGCAC CGACAGCCCCAACTTCCTCTGCTCCGTGCTGCCTACGCACTGGCGCTGCAACAAGACCCTGCCCATCGCTTTCAAGGTGGTGGCCCTAGG GGATGTTCCAGATGGCACTCTGGTCACTGTGATGGCTGGCAATGATGAAAACTACTCGGCTGAGCTGAGAAATGCTACCGCAGCCATGAA GAACCAGGTTGCAAGATTTAATGACCTCAGGTTTGTCGGTCGAAGTGGAAGAGGGAAAAGCTTCACTCTGACCATCACTGTCTTCACAAA CCCACCGCAAGTCGCCACCTACCACAGAGCCATCAAAATCACAGTGGATGGGCCCCGAGAACCTCGAAGACATCGGCAGAAACTAGATGA TCAGACCAAGCCCGGGAGCTTGTCCTTTTCCGAGCGGCTCAGTGAACTGGAGCAGCTGCGGCGCACAGCCATGAGGGTCAGCCCACACCA CCCAGCCCCCACGCCCAACCCTCGTGCCTCCCTGAACCACTCCACTGCCTTTAACCCTCAGCCTCAGAGTCAGATGCAGGATACAAGGCA GATCCAACCATCCCCACCGTGGTCCTACGATCAGTCCTACCAATACCTGGGATCCATTGCCTCTCCTTCTGTGCACCCAGCAACGCCCAT TTCACCTGGACGTGCCAGCGGCATGACAACCCTCTCTGCAGAACTTTCCAGTCGACTCTCAACCCTAGGTGATGGCATCGCTCCTCCACA GAAAGTTCTTTTCCCATCTGAGAAGATTTGTCTTAAGTGGCAACAAACTCATAGAGTTGGAGCTGGGCTCCAGAATTTGGGCAATACCTG TTTTGCCAATGCAGCACTGCAGTGTTTAACCTACACACCACCTCTTGCCAATTACATGCTATCACATGAACACTCCAAAACATGTCATGC AGAAGGCTTTTGTATGATGTGTACAATGCAAGCACATATTACCCAGGCACTCAGTAATCCTGGGGACGTTATTAAACCAATGTTTGTCAT CAATGAGATGCGGCGTATAGCTAGGCACTTCCGTTTTGGAAACCAAGAAGATGCCCATGAATTCCTTCAATACACTGTTGATGCTATGCA GAAAGCATGCTTGAATGGCAGCAATAAATTAGACAGACACACCCAGGCCACCACTCTTGTTTGTCAGATATTTGGAGGATACCTAAGATC TAGAGTCAAATGTTTAAATTGCAAGGGCGTTTCAGATACTTTTGATCCATATCTTGATATAACATTGGAGATAAAGGCTGCTCAGAGTGT CAACAAGGCATTGGAGCAGTTTGTGAAGCCGGAACAGCTTGATGGAGAAAACTCGTACAAGTGCAGCAAGTGTAAAAAGATGGTTCCAGC TTCAAAGAGGTTCACTATCCATAGATCCTCTAATGTTCTTACACTTTCTCTGAAACGTTTTGCAAATTTTACCGGTGGAAAAATTGCTAA GGATGTGAAATACCCTGAGTATCTTGATATTCGGCCATATATGTCTCAACCCAACGGAGAGCCAATTGTCTACGTCTTGTATGCAGTGCT GGTCCACACTGGTTTTAATTGCCATGCTGGCCATTACTTCTGCTACATAAAAGCTAGCAATGGCCTCTGGTATCAAATGAATGACTCCAT TGTATCTACCAGTGATATTAGATCGGTACTCAGCCAACAAGCCTATGTGCTCTTTTATATCAGGTCCCATGATGTGAAAAATGGAGGTGA ACTTACTCATCCCACCCATAGCCCCGGCCAGTCCTCTCCCCGCCCCGTCATCAGTCAGCGGGTTGTCACCAACAAACAGGCTGCGCCAGG CTTTATCGGACCACAGCTTCCCTCTCACATGATAAAGAATCCACCTCACTTAAATGGGACTGGACCATTGAAAGACACGCCAAGCAGTTC CATGTCGAGTCCTAACGGGAATTCCAGTGTCAACAGGGCTAGTCCTGTTAATGCTTCAGCTTCTGTCCAAAACTGGTCAGTTAATAGGTC CTCAGTGATCCCAGAACATCCTAAGAAACAAAAAATTACAATCAGTATTCACAACAAGTTGCCTGTTCGCCAGTGTCAGTCTCAACCTAA CCTTCATAGTAATTCTTTGGAGAACCCTACCAAGCCCGTTCCCTCTTCTACCATTACCAATTCTGCAGTACAGTCTACCTCGAACGCATC TACGATGTCAGTTTCTAGTAAAGTAACAAAACCGATCCCCCGCAGTGAATCCTGCTCCCAGCCCGTGATGAATGGCAAATCCAAGCTGAA CTCCAGCGTGCTGGTGCCCTATGGCGCCGAGTCCTCTGAGGACTCTGACGAGGAGTCAAAGGGGCTGGGCAAGGAGAATGGGATTGGTAC GATTGTGAGCTCCCACTCTCCCGGCCAAGATGCCGAAGATGAGGAGGCCACTCCGCACGAGCTTCAAGAACCCATGACCCTAAACGGTGC TAATAGTGCAGACAGCGACAGTGACCCGAAAGAAAACGGCCTAGCGCCTGATGGTGCCAGCTGCCAAGGCCAGCCTGCCCTGCACTCAGA AAATCCCTTTGCTAAGGCAAACGGTCTTCCTGGAAAGTTGATGCCTGCTCCTTTGCTGTCTCTCCCAGAAGACAAAATCTTAGAGACCTT CAGGCTTAGCAACAAACTGAAAGGCTCGACGGATGAAATGAGTGCACCTGGAGCAGAGAGGGGCCCTCCCGAGGACCGCGACGCCGAGCC TCAGCCTGGCAGCCCCGCCGCCGAATCCCTGGAGGAGCCAGATGCGGCCGCCGGCCTCAGCAGCACCAAGAAGGCTCCGCCGCCCCGCGA TCCCGGCACCCCCGCTACCAAAGAAGGCGCCTGGGAGGCCATGGCCGTCGCCCCCGAGGAGCCTCCGCCCAGCGCCGGCGAGGACATCGT GGGGGACACAGCACCCCCTGACCTGTGTGATCCCGGGAGCTTAACAGGCGATGCGAGCCCGTTGTCCCAGGACGCAAAGGGGATGATCGC GGAGGGCCCGCGGGACTCGGCGTTGGCGGAAGCCCCGGAAGGGTTGAGTCCGGCTCCGCCTGCGCGGTCGGAGGAGCCCTGCGAGCAGCC ACTCCTTGTTCACCCCAGCGGGGACCACGCCCGGGACGCTCAGGACCCATCCCAGAGCTTGGGCGCACCCGAGGCCGCAGAGCGGCCGCC AGCTCCTGTGCTGGACATGGCCCCGGCCGGTCACCCGGAAGGGGACGCTGAGCCTAGCCCCGGCGAGAGGGTCGAGGACGCCGCGGCGCC GAAAGCCCCAGGCCCTTCCCCAGCGAAGGAGAAAATCGGCAGCCTCAGAAAGGTGGACCGAGGCCACTACCGCAGCCGGAGAGAGCGCTC GTCCAGCGGGGAGCCCGCCAGAGAGAGCAGGAGCAAGACTGAGGGCCACCGTCACCGGCGGCGCCGCACCTGCCCCCGGGAGCGCGACCG CCAGGACCGCCACGCCCCGGAGCACCACCCCGGCCACGGCGACAGGCTCAGCCCTGGCGAGCGCCGCTCTCTGGGCAGGTGCAGTCACCA CCACTCCCGACACCGGAGCGGGGTGGAGCTGGACTGGGTCAGACACCACTACACCGAGGGCGAGCGTGGCTGGGGCCGGGAGAAGTTCTA CCCCGACAGGCCGCGCTGGGACAGGTGCCGGTACTACCATGACAGGTACGCCCTGTACGCTGCCCGGGACTGGAAGCCCTTCCACGGCGG CCGCGAGCACGAGCGGGCCGGGCTGCACGAGCGGCCGCACAAGGACCACAACCGGGGCCGTAGGGGCTGCGAGCCGGCCCGGGAGAGGGA GCGGCACCGCCCCAGCAGCCCCCGCGCAGGCGCGCCCCACGCCCTCGCCCCGCACCCCGACCGCTTCTCCCACGACAGAACTGCACTTGT AGCCGGAGACAACTGTAACCTCTCTGATCGGTTTCACGAACACGAAAATGGAAAGTCCCGGAAACGGAGACACGACAGTGTGGAGAACAG TGACAGTCATGTTGAAAAGAAAGCCCGGAGGAGCGAACAGAAGGATCCTCTAGAAGAGCCTAAAGCAAAGAAGCACAAAAAATCAAAGAA GAAAAAGAAATCCAAAGACAAACACCGAGACCGCGACTCCAGGCATCAGCAGGACTCAGACCTCTCAGCAGCGTGCTCTGACGCTGACCT CCACAGACACAAAAAAAAGAAGAAGAAAAAGAAGAGACATTCAAGAAAATCAGAGGACTTTGTTAAAGATTCAGAACTGCACTTACCCAG GGTCACCAGCTTGGAGACTGTCGCCCAGTTCCGGAGAGCCCAGGGTGGCTTTCCTCTCTCTGGTGGCCCGCCTCTGGAAGGCGTCGGACC TTTCCGTGAGAAAACGAAACACTTACGGATGGAAAGCAGGGATGACAGGTGTCGTCTCTTTGAGTATGGCCAGGGTGATTGAAAACTCAG CCTCAAAACAAAAAATTCACTAGTTATGATTCAACGCGTTCAACAGAAGCCATCCCCAGCCCAGCTTAAATTATAAAGATAGACAATAAC TCTGTTCCAATCTGCGTGGTGCTTCTTTAGTAAATACTGTACAGATTTTACCATGGAGAACTTTTTTTTTAGTTTTTACCTTTTCTTAAT TACCCTTATTCCGAATGGACGAACACTTTCTACCACTGCTGACCATTGTAAAATACCGTGTATATAAATCCCATTGAAATAATGCCCTGG AATAGAACATCTCAAATGCTGCTTAATTACAGACTCAGGTCGATTACTTGTATTTCATGTAATGTTCCTCCAAGTTAGACATCTGGTGCA AGACCAACCGGGAGACCATGGAATTGTCAAAAGTACAAACTGACAGTGTGTATATTTAATTTAAAGACTTATTTAAAAACTCACAAGCTC TCACCTAGACTTTGGAGAGCAGTCTGTTTTCTGTAATGTCTGATACTAGAAACTAATTTGCTTATTTTAGTTGTATTCAAGATTTGAAGA TGTATTTTATAGACAAGTTCTGTTTTTGAACTTTGTGGAACTGTTCCAATCAATCAATTTCCCAGTTATGATGAGTATTTACATTATGAA TGTATAACCCAGACATGATTTGTAAAGCCGACAGTATGTTTCTATTACACAACACTTTTTGATACAGCGTCTCTTGTCTTCACTGATACT GGAGTCTCCGTTGTCTGCTTGGTCCCTTCGAGTTTCTAGTTACAGACACAATCATACTGTGATTTTATTTTTAATATGGATATGCTATCA AACTGTGATACACTTATAATTCACTGGTCCTGCATCAGGAGATGGAGTGGGGAAAACTGTATTTAATACAGTTTGTATCTGAATAATCTG TATGGTTTATACAGTTTGTGTTGTTCAGAGATGTTTAAAGTTTGATCTTTGTTTTTCTAAAGATTAAAAAAGCACTTGCCCCACTGTAAA >78697_78697_1_RUNX1-USP42_RUNX1_chr21_36171597_ENST00000300305_USP42_chr7_6154953_ENST00000306177_length(amino acids)=1558AA_BP=316 MASDSIFESFPSYPQCFMRECILGMNPSRDVHDASTSRRFTPPSTALSPGKMSEALPLGAPDAGAALAGKLRSGDRSMVEVLADHPGELV RTDSPNFLCSVLPTHWRCNKTLPIAFKVVALGDVPDGTLVTVMAGNDENYSAELRNATAAMKNQVARFNDLRFVGRSGRGKSFTLTITVF TNPPQVATYHRAIKITVDGPREPRRHRQKLDDQTKPGSLSFSERLSELEQLRRTAMRVSPHHPAPTPNPRASLNHSTAFNPQPQSQMQDT RQIQPSPPWSYDQSYQYLGSIASPSVHPATPISPGRASGMTTLSAELSSRLSTLGDGIAPPQKVLFPSEKICLKWQQTHRVGAGLQNLGN TCFANAALQCLTYTPPLANYMLSHEHSKTCHAEGFCMMCTMQAHITQALSNPGDVIKPMFVINEMRRIARHFRFGNQEDAHEFLQYTVDA MQKACLNGSNKLDRHTQATTLVCQIFGGYLRSRVKCLNCKGVSDTFDPYLDITLEIKAAQSVNKALEQFVKPEQLDGENSYKCSKCKKMV PASKRFTIHRSSNVLTLSLKRFANFTGGKIAKDVKYPEYLDIRPYMSQPNGEPIVYVLYAVLVHTGFNCHAGHYFCYIKASNGLWYQMND SIVSTSDIRSVLSQQAYVLFYIRSHDVKNGGELTHPTHSPGQSSPRPVISQRVVTNKQAAPGFIGPQLPSHMIKNPPHLNGTGPLKDTPS SSMSSPNGNSSVNRASPVNASASVQNWSVNRSSVIPEHPKKQKITISIHNKLPVRQCQSQPNLHSNSLENPTKPVPSSTITNSAVQSTSN ASTMSVSSKVTKPIPRSESCSQPVMNGKSKLNSSVLVPYGAESSEDSDEESKGLGKENGIGTIVSSHSPGQDAEDEEATPHELQEPMTLN GANSADSDSDPKENGLAPDGASCQGQPALHSENPFAKANGLPGKLMPAPLLSLPEDKILETFRLSNKLKGSTDEMSAPGAERGPPEDRDA EPQPGSPAAESLEEPDAAAGLSSTKKAPPPRDPGTPATKEGAWEAMAVAPEEPPPSAGEDIVGDTAPPDLCDPGSLTGDASPLSQDAKGM IAEGPRDSALAEAPEGLSPAPPARSEEPCEQPLLVHPSGDHARDAQDPSQSLGAPEAAERPPAPVLDMAPAGHPEGDAEPSPGERVEDAA APKAPGPSPAKEKIGSLRKVDRGHYRSRRERSSSGEPARESRSKTEGHRHRRRRTCPRERDRQDRHAPEHHPGHGDRLSPGERRSLGRCS HHHSRHRSGVELDWVRHHYTEGERGWGREKFYPDRPRWDRCRYYHDRYALYAARDWKPFHGGREHERAGLHERPHKDHNRGRRGCEPARE RERHRPSSPRAGAPHALAPHPDRFSHDRTALVAGDNCNLSDRFHEHENGKSRKRRHDSVENSDSHVEKKARRSEQKDPLEEPKAKKHKKS KKKKKSKDKHRDRDSRHQQDSDLSAACSDADLHRHKKKKKKKKRHSRKSEDFVKDSELHLPRVTSLETVAQFRRAQGGFPLSGGPPLEGV -------------------------------------------------------------- >78697_78697_2_RUNX1-USP42_RUNX1_chr21_36171597_ENST00000325074_USP42_chr7_6154953_ENST00000306177_length(transcript)=5687nt_BP=931nt ATGCCCGCAGCACCGCGGGGACCGGCGCAGGGGGAAGCGGCCGCCCGCACGCGAAGCCGGGATGCCAGCACGAGCCGCCGCTTCACGCCG CCTTCCACCGCGCTGAGCCCAGGCAAGATGAGCGAGGCGTTGCCGCTGGGCGCCCCGGACGCCGGCGCTGCCCTGGCCGGCAAGCTGAGG AGCGGCGACCGCAGCATGGTGGAGGTGCTGGCCGACCACCCGGGCGAGCTGGTGCGCACCGACAGCCCCAACTTCCTCTGCTCCGTGCTG CCTACGCACTGGCGCTGCAACAAGACCCTGCCCATCGCTTTCAAGGTGGTGGCCCTAGGGGATGTTCCAGATGGCACTCTGGTCACTGTG ATGGCTGGCAATGATGAAAACTACTCGGCTGAGCTGAGAAATGCTACCGCAGCCATGAAGAACCAGGTTGCAAGATTTAATGACCTCAGG TTTGTCGGTCGAAGTGGAAGAGGGAAAAGCTTCACTCTGACCATCACTGTCTTCACAAACCCACCGCAAGTCGCCACCTACCACAGAGCC ATCAAAATCACAGTGGATGGGCCCCGAGAACCTCGAAGACATCGGCAGAAACTAGATGATCAGACCAAGCCCGGGAGCTTGTCCTTTTCC GAGCGGCTCAGTGAACTGGAGCAGCTGCGGCGCACAGCCATGAGGGTCAGCCCACACCACCCAGCCCCCACGCCCAACCCTCGTGCCTCC CTGAACCACTCCACTGCCTTTAACCCTCAGCCTCAGAGTCAGATGCAGGATACAAGGCAGATCCAACCATCCCCACCGTGGTCCTACGAT CAGTCCTACCAATACCTGGGATCCATTGCCTCTCCTTCTGTGCACCCAGCAACGCCCATTTCACCTGGACGTGCCAGCGGCATGACAACC CTCTCTGCAGAACTTTCCAGTCGACTCTCAACCCTAGGTGATGGCATCGCTCCTCCACAGAAAGTTCTTTTCCCATCTGAGAAGATTTGT CTTAAGTGGCAACAAACTCATAGAGTTGGAGCTGGGCTCCAGAATTTGGGCAATACCTGTTTTGCCAATGCAGCACTGCAGTGTTTAACC TACACACCACCTCTTGCCAATTACATGCTATCACATGAACACTCCAAAACATGTCATGCAGAAGGCTTTTGTATGATGTGTACAATGCAA GCACATATTACCCAGGCACTCAGTAATCCTGGGGACGTTATTAAACCAATGTTTGTCATCAATGAGATGCGGCGTATAGCTAGGCACTTC CGTTTTGGAAACCAAGAAGATGCCCATGAATTCCTTCAATACACTGTTGATGCTATGCAGAAAGCATGCTTGAATGGCAGCAATAAATTA GACAGACACACCCAGGCCACCACTCTTGTTTGTCAGATATTTGGAGGATACCTAAGATCTAGAGTCAAATGTTTAAATTGCAAGGGCGTT TCAGATACTTTTGATCCATATCTTGATATAACATTGGAGATAAAGGCTGCTCAGAGTGTCAACAAGGCATTGGAGCAGTTTGTGAAGCCG GAACAGCTTGATGGAGAAAACTCGTACAAGTGCAGCAAGTGTAAAAAGATGGTTCCAGCTTCAAAGAGGTTCACTATCCATAGATCCTCT AATGTTCTTACACTTTCTCTGAAACGTTTTGCAAATTTTACCGGTGGAAAAATTGCTAAGGATGTGAAATACCCTGAGTATCTTGATATT CGGCCATATATGTCTCAACCCAACGGAGAGCCAATTGTCTACGTCTTGTATGCAGTGCTGGTCCACACTGGTTTTAATTGCCATGCTGGC CATTACTTCTGCTACATAAAAGCTAGCAATGGCCTCTGGTATCAAATGAATGACTCCATTGTATCTACCAGTGATATTAGATCGGTACTC AGCCAACAAGCCTATGTGCTCTTTTATATCAGGTCCCATGATGTGAAAAATGGAGGTGAACTTACTCATCCCACCCATAGCCCCGGCCAG TCCTCTCCCCGCCCCGTCATCAGTCAGCGGGTTGTCACCAACAAACAGGCTGCGCCAGGCTTTATCGGACCACAGCTTCCCTCTCACATG ATAAAGAATCCACCTCACTTAAATGGGACTGGACCATTGAAAGACACGCCAAGCAGTTCCATGTCGAGTCCTAACGGGAATTCCAGTGTC AACAGGGCTAGTCCTGTTAATGCTTCAGCTTCTGTCCAAAACTGGTCAGTTAATAGGTCCTCAGTGATCCCAGAACATCCTAAGAAACAA AAAATTACAATCAGTATTCACAACAAGTTGCCTGTTCGCCAGTGTCAGTCTCAACCTAACCTTCATAGTAATTCTTTGGAGAACCCTACC AAGCCCGTTCCCTCTTCTACCATTACCAATTCTGCAGTACAGTCTACCTCGAACGCATCTACGATGTCAGTTTCTAGTAAAGTAACAAAA CCGATCCCCCGCAGTGAATCCTGCTCCCAGCCCGTGATGAATGGCAAATCCAAGCTGAACTCCAGCGTGCTGGTGCCCTATGGCGCCGAG TCCTCTGAGGACTCTGACGAGGAGTCAAAGGGGCTGGGCAAGGAGAATGGGATTGGTACGATTGTGAGCTCCCACTCTCCCGGCCAAGAT GCCGAAGATGAGGAGGCCACTCCGCACGAGCTTCAAGAACCCATGACCCTAAACGGTGCTAATAGTGCAGACAGCGACAGTGACCCGAAA GAAAACGGCCTAGCGCCTGATGGTGCCAGCTGCCAAGGCCAGCCTGCCCTGCACTCAGAAAATCCCTTTGCTAAGGCAAACGGTCTTCCT GGAAAGTTGATGCCTGCTCCTTTGCTGTCTCTCCCAGAAGACAAAATCTTAGAGACCTTCAGGCTTAGCAACAAACTGAAAGGCTCGACG GATGAAATGAGTGCACCTGGAGCAGAGAGGGGCCCTCCCGAGGACCGCGACGCCGAGCCTCAGCCTGGCAGCCCCGCCGCCGAATCCCTG GAGGAGCCAGATGCGGCCGCCGGCCTCAGCAGCACCAAGAAGGCTCCGCCGCCCCGCGATCCCGGCACCCCCGCTACCAAAGAAGGCGCC TGGGAGGCCATGGCCGTCGCCCCCGAGGAGCCTCCGCCCAGCGCCGGCGAGGACATCGTGGGGGACACAGCACCCCCTGACCTGTGTGAT CCCGGGAGCTTAACAGGCGATGCGAGCCCGTTGTCCCAGGACGCAAAGGGGATGATCGCGGAGGGCCCGCGGGACTCGGCGTTGGCGGAA GCCCCGGAAGGGTTGAGTCCGGCTCCGCCTGCGCGGTCGGAGGAGCCCTGCGAGCAGCCACTCCTTGTTCACCCCAGCGGGGACCACGCC CGGGACGCTCAGGACCCATCCCAGAGCTTGGGCGCACCCGAGGCCGCAGAGCGGCCGCCAGCTCCTGTGCTGGACATGGCCCCGGCCGGT CACCCGGAAGGGGACGCTGAGCCTAGCCCCGGCGAGAGGGTCGAGGACGCCGCGGCGCCGAAAGCCCCAGGCCCTTCCCCAGCGAAGGAG AAAATCGGCAGCCTCAGAAAGGTGGACCGAGGCCACTACCGCAGCCGGAGAGAGCGCTCGTCCAGCGGGGAGCCCGCCAGAGAGAGCAGG AGCAAGACTGAGGGCCACCGTCACCGGCGGCGCCGCACCTGCCCCCGGGAGCGCGACCGCCAGGACCGCCACGCCCCGGAGCACCACCCC GGCCACGGCGACAGGCTCAGCCCTGGCGAGCGCCGCTCTCTGGGCAGGTGCAGTCACCACCACTCCCGACACCGGAGCGGGGTGGAGCTG GACTGGGTCAGACACCACTACACCGAGGGCGAGCGTGGCTGGGGCCGGGAGAAGTTCTACCCCGACAGGCCGCGCTGGGACAGGTGCCGG TACTACCATGACAGGTACGCCCTGTACGCTGCCCGGGACTGGAAGCCCTTCCACGGCGGCCGCGAGCACGAGCGGGCCGGGCTGCACGAG CGGCCGCACAAGGACCACAACCGGGGCCGTAGGGGCTGCGAGCCGGCCCGGGAGAGGGAGCGGCACCGCCCCAGCAGCCCCCGCGCAGGC GCGCCCCACGCCCTCGCCCCGCACCCCGACCGCTTCTCCCACGACAGAACTGCACTTGTAGCCGGAGACAACTGTAACCTCTCTGATCGG TTTCACGAACACGAAAATGGAAAGTCCCGGAAACGGAGACACGACAGTGTGGAGAACAGTGACAGTCATGTTGAAAAGAAAGCCCGGAGG AGCGAACAGAAGGATCCTCTAGAAGAGCCTAAAGCAAAGAAGCACAAAAAATCAAAGAAGAAAAAGAAATCCAAAGACAAACACCGAGAC CGCGACTCCAGGCATCAGCAGGACTCAGACCTCTCAGCAGCGTGCTCTGACGCTGACCTCCACAGACACAAAAAAAAGAAGAAGAAAAAG AAGAGACATTCAAGAAAATCAGAGGACTTTGTTAAAGATTCAGAACTGCACTTACCCAGGGTCACCAGCTTGGAGACTGTCGCCCAGTTC CGGAGAGCCCAGGGTGGCTTTCCTCTCTCTGGTGGCCCGCCTCTGGAAGGCGTCGGACCTTTCCGTGAGAAAACGAAACACTTACGGATG GAAAGCAGGGATGACAGGTGTCGTCTCTTTGAGTATGGCCAGGGTGATTGAAAACTCAGCCTCAAAACAAAAAATTCACTAGTTATGATT CAACGCGTTCAACAGAAGCCATCCCCAGCCCAGCTTAAATTATAAAGATAGACAATAACTCTGTTCCAATCTGCGTGGTGCTTCTTTAGT AAATACTGTACAGATTTTACCATGGAGAACTTTTTTTTTAGTTTTTACCTTTTCTTAATTACCCTTATTCCGAATGGACGAACACTTTCT ACCACTGCTGACCATTGTAAAATACCGTGTATATAAATCCCATTGAAATAATGCCCTGGAATAGAACATCTCAAATGCTGCTTAATTACA GACTCAGGTCGATTACTTGTATTTCATGTAATGTTCCTCCAAGTTAGACATCTGGTGCAAGACCAACCGGGAGACCATGGAATTGTCAAA AGTACAAACTGACAGTGTGTATATTTAATTTAAAGACTTATTTAAAAACTCACAAGCTCTCACCTAGACTTTGGAGAGCAGTCTGTTTTC TGTAATGTCTGATACTAGAAACTAATTTGCTTATTTTAGTTGTATTCAAGATTTGAAGATGTATTTTATAGACAAGTTCTGTTTTTGAAC TTTGTGGAACTGTTCCAATCAATCAATTTCCCAGTTATGATGAGTATTTACATTATGAATGTATAACCCAGACATGATTTGTAAAGCCGA CAGTATGTTTCTATTACACAACACTTTTTGATACAGCGTCTCTTGTCTTCACTGATACTGGAGTCTCCGTTGTCTGCTTGGTCCCTTCGA GTTTCTAGTTACAGACACAATCATACTGTGATTTTATTTTTAATATGGATATGCTATCAAACTGTGATACACTTATAATTCACTGGTCCT GCATCAGGAGATGGAGTGGGGAAAACTGTATTTAATACAGTTTGTATCTGAATAATCTGTATGGTTTATACAGTTTGTGTTGTTCAGAGA TGTTTAAAGTTTGATCTTTGTTTTTCTAAAGATTAAAAAAGCACTTGCCCCACTGTAAATATACAGCATGTAAAATTTCTATAGTATATA >78697_78697_2_RUNX1-USP42_RUNX1_chr21_36171597_ENST00000325074_USP42_chr7_6154953_ENST00000306177_length(amino acids)=1546AA_BP=304 MPAAPRGPAQGEAAARTRSRDASTSRRFTPPSTALSPGKMSEALPLGAPDAGAALAGKLRSGDRSMVEVLADHPGELVRTDSPNFLCSVL PTHWRCNKTLPIAFKVVALGDVPDGTLVTVMAGNDENYSAELRNATAAMKNQVARFNDLRFVGRSGRGKSFTLTITVFTNPPQVATYHRA IKITVDGPREPRRHRQKLDDQTKPGSLSFSERLSELEQLRRTAMRVSPHHPAPTPNPRASLNHSTAFNPQPQSQMQDTRQIQPSPPWSYD QSYQYLGSIASPSVHPATPISPGRASGMTTLSAELSSRLSTLGDGIAPPQKVLFPSEKICLKWQQTHRVGAGLQNLGNTCFANAALQCLT YTPPLANYMLSHEHSKTCHAEGFCMMCTMQAHITQALSNPGDVIKPMFVINEMRRIARHFRFGNQEDAHEFLQYTVDAMQKACLNGSNKL DRHTQATTLVCQIFGGYLRSRVKCLNCKGVSDTFDPYLDITLEIKAAQSVNKALEQFVKPEQLDGENSYKCSKCKKMVPASKRFTIHRSS NVLTLSLKRFANFTGGKIAKDVKYPEYLDIRPYMSQPNGEPIVYVLYAVLVHTGFNCHAGHYFCYIKASNGLWYQMNDSIVSTSDIRSVL SQQAYVLFYIRSHDVKNGGELTHPTHSPGQSSPRPVISQRVVTNKQAAPGFIGPQLPSHMIKNPPHLNGTGPLKDTPSSSMSSPNGNSSV NRASPVNASASVQNWSVNRSSVIPEHPKKQKITISIHNKLPVRQCQSQPNLHSNSLENPTKPVPSSTITNSAVQSTSNASTMSVSSKVTK PIPRSESCSQPVMNGKSKLNSSVLVPYGAESSEDSDEESKGLGKENGIGTIVSSHSPGQDAEDEEATPHELQEPMTLNGANSADSDSDPK ENGLAPDGASCQGQPALHSENPFAKANGLPGKLMPAPLLSLPEDKILETFRLSNKLKGSTDEMSAPGAERGPPEDRDAEPQPGSPAAESL EEPDAAAGLSSTKKAPPPRDPGTPATKEGAWEAMAVAPEEPPPSAGEDIVGDTAPPDLCDPGSLTGDASPLSQDAKGMIAEGPRDSALAE APEGLSPAPPARSEEPCEQPLLVHPSGDHARDAQDPSQSLGAPEAAERPPAPVLDMAPAGHPEGDAEPSPGERVEDAAAPKAPGPSPAKE KIGSLRKVDRGHYRSRRERSSSGEPARESRSKTEGHRHRRRRTCPRERDRQDRHAPEHHPGHGDRLSPGERRSLGRCSHHHSRHRSGVEL DWVRHHYTEGERGWGREKFYPDRPRWDRCRYYHDRYALYAARDWKPFHGGREHERAGLHERPHKDHNRGRRGCEPARERERHRPSSPRAG APHALAPHPDRFSHDRTALVAGDNCNLSDRFHEHENGKSRKRRHDSVENSDSHVEKKARRSEQKDPLEEPKAKKHKKSKKKKKSKDKHRD RDSRHQQDSDLSAACSDADLHRHKKKKKKKKRHSRKSEDFVKDSELHLPRVTSLETVAQFRRAQGGFPLSGGPPLEGVGPFREKTKHLRM -------------------------------------------------------------- >78697_78697_3_RUNX1-USP42_RUNX1_chr21_36171597_ENST00000344691_USP42_chr7_6154953_ENST00000306177_length(transcript)=7220nt_BP=2464nt CATAGAGCCAGCGGGCGCGGGCGGGACGGGCGCCCCGCGGCCGGACCCAGCCAGGGCACCACGCTGCCCGGCCCTGCGCCGCCAGGCACT TCTTTCCGGGGCTCCTAGGGACGCCAGAAGGAAGTCAACCTCTGCTGCTTCTCCTTGGCCTGCGTTGGACCTTCCTTTTTTTGTTGTTTT TTTTTGTTTTTCCCCTTTCTTCCTTTTGAATTAACTGGCTTCTTGGCTGGATGTTTTCAACTTCTTTCCTGGCTGCGAACTTTTCCCCAA TTGTTTTCCTTTTACAACAGGGGGAGAAAGTGCTCTGTGGTCCGAGGCGAGCCGTGAAGTTGCGTGTGCGTGGCAGTGTGCGTGGCAGGA TGTGCGTGCGTGTGTAACCCGAGCCGCCCGATCTGTTTCGATCTGCGCCGCGGAGCCCTCCCTCAAGGCCCGCTCCACCTGCTGCGGTTA CGCGGCGCTCGTGGGTGTTCGTGCCTCGGAGCAGCTAACCGGCGGGTGCTGGGCGACGGTGGAGGAGTATCGTCTCGCTGCTGCCCGAGT CAGGGCTGAGTCACCCAGCTGATGTAGACAGTGGCTGCCTTCCGAAGAGTGCGTGTTTGCATGTGTGTGACTCTGCGGCTGCTCAACTCC CAACAAACCAGAGGACCAGCCACAAACTTAACCAACATCCCCAAACCCGAGTTCACAGATGTGGGAGAGCTGTAGAACCCTGAGTGTCAT CGACTGGGCCTTCTTATGATTGTTGTTTTAAGATTAGCTGAAGATCTCTGAAACGCTGAATTTTCTGCACTGAGCGTTTTGACAGAATTC ATTGAGAGAACAGAGAACATGACAAGTACTTCTAGCTCAGCACTGCTCCAACTACTGAAGCTGATTTTCAAGGCTACTTAAAAAAATCTG CAGCGTACATTAATGGATTTCTGTTGTGTTTAAATTCTCCACAGATTGTATTGTAAATATTTTATGAAGTAGAGCATATGTATATATTTA TATATACGTGCACATACATTAGTAGCACTACCTTTGGAAGTCTCAGCTCTTGCTTTTCGGGACTGAAGCCAGTTTTGCATGATAAAAGTG GCCTTGTTACGGGAGATAATTGTGTTCTGTTGGGACTTTAGACAAAACTCACCTGCAAAAAACTGACAGGCATTAACTACTGGAACTTCC AAATAATGTGTTTGCTGATCGTTTTACTCTTCGCATAAATATTTTAGGAAGTGTATGAGAATTTTGCCTTCAGGAACTTTTCTAACAGCC AAAGACAGAACTTAACCTCTGCAAGCAAGATTCGTGGAAGATAGTCTCCACTTTTTAATGCACTAAGCAATCGGTTGCTAGGAGCCCATC CTGGGTCAGAGGCCGATCCGCAGAACCAGAACGTTTTCCCCTCCTGGACTGTTAGTAACTTAGTCTCCCTCCTCCCCTAACCACCCCCGC CCCCCCCCACCCCCCGCAGTAATAAAGGCCCCTGAACGTGTATGTTGGTCTCCCGGGAGCTGCTTGCTGAAGATCCGCGCCCCTGTCGCC GTCTGGTAGGAGCTGTTTGCAGGGTCCTAACTCAATCGGCTTGTTGTGATGCGTATCCCCGTAGATGCCAGCACGAGCCGCCGCTTCACG CCGCCTTCCACCGCGCTGAGCCCAGGCAAGATGAGCGAGGCGTTGCCGCTGGGCGCCCCGGACGCCGGCGCTGCCCTGGCCGGCAAGCTG AGGAGCGGCGACCGCAGCATGGTGGAGGTGCTGGCCGACCACCCGGGCGAGCTGGTGCGCACCGACAGCCCCAACTTCCTCTGCTCCGTG CTGCCTACGCACTGGCGCTGCAACAAGACCCTGCCCATCGCTTTCAAGGTGGTGGCCCTAGGGGATGTTCCAGATGGCACTCTGGTCACT GTGATGGCTGGCAATGATGAAAACTACTCGGCTGAGCTGAGAAATGCTACCGCAGCCATGAAGAACCAGGTTGCAAGATTTAATGACCTC AGGTTTGTCGGTCGAAGTGGAAGAGGGAAAAGCTTCACTCTGACCATCACTGTCTTCACAAACCCACCGCAAGTCGCCACCTACCACAGA GCCATCAAAATCACAGTGGATGGGCCCCGAGAACCTCGAAGACATCGGCAGAAACTAGATGATCAGACCAAGCCCGGGAGCTTGTCCTTT TCCGAGCGGCTCAGTGAACTGGAGCAGCTGCGGCGCACAGCCATGAGGGTCAGCCCACACCACCCAGCCCCCACGCCCAACCCTCGTGCC TCCCTGAACCACTCCACTGCCTTTAACCCTCAGCCTCAGAGTCAGATGCAGGATACAAGGCAGATCCAACCATCCCCACCGTGGTCCTAC GATCAGTCCTACCAATACCTGGGATCCATTGCCTCTCCTTCTGTGCACCCAGCAACGCCCATTTCACCTGGACGTGCCAGCGGCATGACA ACCCTCTCTGCAGAACTTTCCAGTCGACTCTCAACCCTAGGTGATGGCATCGCTCCTCCACAGAAAGTTCTTTTCCCATCTGAGAAGATT TGTCTTAAGTGGCAACAAACTCATAGAGTTGGAGCTGGGCTCCAGAATTTGGGCAATACCTGTTTTGCCAATGCAGCACTGCAGTGTTTA ACCTACACACCACCTCTTGCCAATTACATGCTATCACATGAACACTCCAAAACATGTCATGCAGAAGGCTTTTGTATGATGTGTACAATG CAAGCACATATTACCCAGGCACTCAGTAATCCTGGGGACGTTATTAAACCAATGTTTGTCATCAATGAGATGCGGCGTATAGCTAGGCAC TTCCGTTTTGGAAACCAAGAAGATGCCCATGAATTCCTTCAATACACTGTTGATGCTATGCAGAAAGCATGCTTGAATGGCAGCAATAAA TTAGACAGACACACCCAGGCCACCACTCTTGTTTGTCAGATATTTGGAGGATACCTAAGATCTAGAGTCAAATGTTTAAATTGCAAGGGC GTTTCAGATACTTTTGATCCATATCTTGATATAACATTGGAGATAAAGGCTGCTCAGAGTGTCAACAAGGCATTGGAGCAGTTTGTGAAG CCGGAACAGCTTGATGGAGAAAACTCGTACAAGTGCAGCAAGTGTAAAAAGATGGTTCCAGCTTCAAAGAGGTTCACTATCCATAGATCC TCTAATGTTCTTACACTTTCTCTGAAACGTTTTGCAAATTTTACCGGTGGAAAAATTGCTAAGGATGTGAAATACCCTGAGTATCTTGAT ATTCGGCCATATATGTCTCAACCCAACGGAGAGCCAATTGTCTACGTCTTGTATGCAGTGCTGGTCCACACTGGTTTTAATTGCCATGCT GGCCATTACTTCTGCTACATAAAAGCTAGCAATGGCCTCTGGTATCAAATGAATGACTCCATTGTATCTACCAGTGATATTAGATCGGTA CTCAGCCAACAAGCCTATGTGCTCTTTTATATCAGGTCCCATGATGTGAAAAATGGAGGTGAACTTACTCATCCCACCCATAGCCCCGGC CAGTCCTCTCCCCGCCCCGTCATCAGTCAGCGGGTTGTCACCAACAAACAGGCTGCGCCAGGCTTTATCGGACCACAGCTTCCCTCTCAC ATGATAAAGAATCCACCTCACTTAAATGGGACTGGACCATTGAAAGACACGCCAAGCAGTTCCATGTCGAGTCCTAACGGGAATTCCAGT GTCAACAGGGCTAGTCCTGTTAATGCTTCAGCTTCTGTCCAAAACTGGTCAGTTAATAGGTCCTCAGTGATCCCAGAACATCCTAAGAAA CAAAAAATTACAATCAGTATTCACAACAAGTTGCCTGTTCGCCAGTGTCAGTCTCAACCTAACCTTCATAGTAATTCTTTGGAGAACCCT ACCAAGCCCGTTCCCTCTTCTACCATTACCAATTCTGCAGTACAGTCTACCTCGAACGCATCTACGATGTCAGTTTCTAGTAAAGTAACA AAACCGATCCCCCGCAGTGAATCCTGCTCCCAGCCCGTGATGAATGGCAAATCCAAGCTGAACTCCAGCGTGCTGGTGCCCTATGGCGCC GAGTCCTCTGAGGACTCTGACGAGGAGTCAAAGGGGCTGGGCAAGGAGAATGGGATTGGTACGATTGTGAGCTCCCACTCTCCCGGCCAA GATGCCGAAGATGAGGAGGCCACTCCGCACGAGCTTCAAGAACCCATGACCCTAAACGGTGCTAATAGTGCAGACAGCGACAGTGACCCG AAAGAAAACGGCCTAGCGCCTGATGGTGCCAGCTGCCAAGGCCAGCCTGCCCTGCACTCAGAAAATCCCTTTGCTAAGGCAAACGGTCTT CCTGGAAAGTTGATGCCTGCTCCTTTGCTGTCTCTCCCAGAAGACAAAATCTTAGAGACCTTCAGGCTTAGCAACAAACTGAAAGGCTCG ACGGATGAAATGAGTGCACCTGGAGCAGAGAGGGGCCCTCCCGAGGACCGCGACGCCGAGCCTCAGCCTGGCAGCCCCGCCGCCGAATCC CTGGAGGAGCCAGATGCGGCCGCCGGCCTCAGCAGCACCAAGAAGGCTCCGCCGCCCCGCGATCCCGGCACCCCCGCTACCAAAGAAGGC GCCTGGGAGGCCATGGCCGTCGCCCCCGAGGAGCCTCCGCCCAGCGCCGGCGAGGACATCGTGGGGGACACAGCACCCCCTGACCTGTGT GATCCCGGGAGCTTAACAGGCGATGCGAGCCCGTTGTCCCAGGACGCAAAGGGGATGATCGCGGAGGGCCCGCGGGACTCGGCGTTGGCG GAAGCCCCGGAAGGGTTGAGTCCGGCTCCGCCTGCGCGGTCGGAGGAGCCCTGCGAGCAGCCACTCCTTGTTCACCCCAGCGGGGACCAC GCCCGGGACGCTCAGGACCCATCCCAGAGCTTGGGCGCACCCGAGGCCGCAGAGCGGCCGCCAGCTCCTGTGCTGGACATGGCCCCGGCC GGTCACCCGGAAGGGGACGCTGAGCCTAGCCCCGGCGAGAGGGTCGAGGACGCCGCGGCGCCGAAAGCCCCAGGCCCTTCCCCAGCGAAG GAGAAAATCGGCAGCCTCAGAAAGGTGGACCGAGGCCACTACCGCAGCCGGAGAGAGCGCTCGTCCAGCGGGGAGCCCGCCAGAGAGAGC AGGAGCAAGACTGAGGGCCACCGTCACCGGCGGCGCCGCACCTGCCCCCGGGAGCGCGACCGCCAGGACCGCCACGCCCCGGAGCACCAC CCCGGCCACGGCGACAGGCTCAGCCCTGGCGAGCGCCGCTCTCTGGGCAGGTGCAGTCACCACCACTCCCGACACCGGAGCGGGGTGGAG CTGGACTGGGTCAGACACCACTACACCGAGGGCGAGCGTGGCTGGGGCCGGGAGAAGTTCTACCCCGACAGGCCGCGCTGGGACAGGTGC CGGTACTACCATGACAGGTACGCCCTGTACGCTGCCCGGGACTGGAAGCCCTTCCACGGCGGCCGCGAGCACGAGCGGGCCGGGCTGCAC GAGCGGCCGCACAAGGACCACAACCGGGGCCGTAGGGGCTGCGAGCCGGCCCGGGAGAGGGAGCGGCACCGCCCCAGCAGCCCCCGCGCA GGCGCGCCCCACGCCCTCGCCCCGCACCCCGACCGCTTCTCCCACGACAGAACTGCACTTGTAGCCGGAGACAACTGTAACCTCTCTGAT CGGTTTCACGAACACGAAAATGGAAAGTCCCGGAAACGGAGACACGACAGTGTGGAGAACAGTGACAGTCATGTTGAAAAGAAAGCCCGG AGGAGCGAACAGAAGGATCCTCTAGAAGAGCCTAAAGCAAAGAAGCACAAAAAATCAAAGAAGAAAAAGAAATCCAAAGACAAACACCGA GACCGCGACTCCAGGCATCAGCAGGACTCAGACCTCTCAGCAGCGTGCTCTGACGCTGACCTCCACAGACACAAAAAAAAGAAGAAGAAA AAGAAGAGACATTCAAGAAAATCAGAGGACTTTGTTAAAGATTCAGAACTGCACTTACCCAGGGTCACCAGCTTGGAGACTGTCGCCCAG TTCCGGAGAGCCCAGGGTGGCTTTCCTCTCTCTGGTGGCCCGCCTCTGGAAGGCGTCGGACCTTTCCGTGAGAAAACGAAACACTTACGG ATGGAAAGCAGGGATGACAGGTGTCGTCTCTTTGAGTATGGCCAGGGTGATTGAAAACTCAGCCTCAAAACAAAAAATTCACTAGTTATG ATTCAACGCGTTCAACAGAAGCCATCCCCAGCCCAGCTTAAATTATAAAGATAGACAATAACTCTGTTCCAATCTGCGTGGTGCTTCTTT AGTAAATACTGTACAGATTTTACCATGGAGAACTTTTTTTTTAGTTTTTACCTTTTCTTAATTACCCTTATTCCGAATGGACGAACACTT TCTACCACTGCTGACCATTGTAAAATACCGTGTATATAAATCCCATTGAAATAATGCCCTGGAATAGAACATCTCAAATGCTGCTTAATT ACAGACTCAGGTCGATTACTTGTATTTCATGTAATGTTCCTCCAAGTTAGACATCTGGTGCAAGACCAACCGGGAGACCATGGAATTGTC AAAAGTACAAACTGACAGTGTGTATATTTAATTTAAAGACTTATTTAAAAACTCACAAGCTCTCACCTAGACTTTGGAGAGCAGTCTGTT TTCTGTAATGTCTGATACTAGAAACTAATTTGCTTATTTTAGTTGTATTCAAGATTTGAAGATGTATTTTATAGACAAGTTCTGTTTTTG AACTTTGTGGAACTGTTCCAATCAATCAATTTCCCAGTTATGATGAGTATTTACATTATGAATGTATAACCCAGACATGATTTGTAAAGC CGACAGTATGTTTCTATTACACAACACTTTTTGATACAGCGTCTCTTGTCTTCACTGATACTGGAGTCTCCGTTGTCTGCTTGGTCCCTT CGAGTTTCTAGTTACAGACACAATCATACTGTGATTTTATTTTTAATATGGATATGCTATCAAACTGTGATACACTTATAATTCACTGGT CCTGCATCAGGAGATGGAGTGGGGAAAACTGTATTTAATACAGTTTGTATCTGAATAATCTGTATGGTTTATACAGTTTGTGTTGTTCAG AGATGTTTAAAGTTTGATCTTTGTTTTTCTAAAGATTAAAAAAGCACTTGCCCCACTGTAAATATACAGCATGTAAAATTTCTATAGTAT >78697_78697_3_RUNX1-USP42_RUNX1_chr21_36171597_ENST00000344691_USP42_chr7_6154953_ENST00000306177_length(amino acids)=1531AA_BP=289 MRIPVDASTSRRFTPPSTALSPGKMSEALPLGAPDAGAALAGKLRSGDRSMVEVLADHPGELVRTDSPNFLCSVLPTHWRCNKTLPIAFK VVALGDVPDGTLVTVMAGNDENYSAELRNATAAMKNQVARFNDLRFVGRSGRGKSFTLTITVFTNPPQVATYHRAIKITVDGPREPRRHR QKLDDQTKPGSLSFSERLSELEQLRRTAMRVSPHHPAPTPNPRASLNHSTAFNPQPQSQMQDTRQIQPSPPWSYDQSYQYLGSIASPSVH PATPISPGRASGMTTLSAELSSRLSTLGDGIAPPQKVLFPSEKICLKWQQTHRVGAGLQNLGNTCFANAALQCLTYTPPLANYMLSHEHS KTCHAEGFCMMCTMQAHITQALSNPGDVIKPMFVINEMRRIARHFRFGNQEDAHEFLQYTVDAMQKACLNGSNKLDRHTQATTLVCQIFG GYLRSRVKCLNCKGVSDTFDPYLDITLEIKAAQSVNKALEQFVKPEQLDGENSYKCSKCKKMVPASKRFTIHRSSNVLTLSLKRFANFTG GKIAKDVKYPEYLDIRPYMSQPNGEPIVYVLYAVLVHTGFNCHAGHYFCYIKASNGLWYQMNDSIVSTSDIRSVLSQQAYVLFYIRSHDV KNGGELTHPTHSPGQSSPRPVISQRVVTNKQAAPGFIGPQLPSHMIKNPPHLNGTGPLKDTPSSSMSSPNGNSSVNRASPVNASASVQNW SVNRSSVIPEHPKKQKITISIHNKLPVRQCQSQPNLHSNSLENPTKPVPSSTITNSAVQSTSNASTMSVSSKVTKPIPRSESCSQPVMNG KSKLNSSVLVPYGAESSEDSDEESKGLGKENGIGTIVSSHSPGQDAEDEEATPHELQEPMTLNGANSADSDSDPKENGLAPDGASCQGQP ALHSENPFAKANGLPGKLMPAPLLSLPEDKILETFRLSNKLKGSTDEMSAPGAERGPPEDRDAEPQPGSPAAESLEEPDAAAGLSSTKKA PPPRDPGTPATKEGAWEAMAVAPEEPPPSAGEDIVGDTAPPDLCDPGSLTGDASPLSQDAKGMIAEGPRDSALAEAPEGLSPAPPARSEE PCEQPLLVHPSGDHARDAQDPSQSLGAPEAAERPPAPVLDMAPAGHPEGDAEPSPGERVEDAAAPKAPGPSPAKEKIGSLRKVDRGHYRS RRERSSSGEPARESRSKTEGHRHRRRRTCPRERDRQDRHAPEHHPGHGDRLSPGERRSLGRCSHHHSRHRSGVELDWVRHHYTEGERGWG REKFYPDRPRWDRCRYYHDRYALYAARDWKPFHGGREHERAGLHERPHKDHNRGRRGCEPARERERHRPSSPRAGAPHALAPHPDRFSHD RTALVAGDNCNLSDRFHEHENGKSRKRRHDSVENSDSHVEKKARRSEQKDPLEEPKAKKHKKSKKKKKSKDKHRDRDSRHQQDSDLSAAC SDADLHRHKKKKKKKKRHSRKSEDFVKDSELHLPRVTSLETVAQFRRAQGGFPLSGGPPLEGVGPFREKTKHLRMESRDDRCRLFEYGQG -------------------------------------------------------------- >78697_78697_4_RUNX1-USP42_RUNX1_chr21_36171597_ENST00000399240_USP42_chr7_6154953_ENST00000306177_length(transcript)=5521nt_BP=765nt TGAAGATCCGCGCCCCTGTCGCCGTCTGGTAGGAGCTGTTTGCAGGGTCCTAACTCAATCGGCTTGTTGTGATGCGTATCCCCGTAGATG CCAGCACGAGCCGCCGCTTCACGCCGCCTTCCACCGCGCTGAGCCCAGGCAAGATGAGCGAGGCGTTGCCGCTGGGCGCCCCGGACGCCG GCGCTGCCCTGGCCGGCAAGCTGAGGAGCGGCGACCGCAGCATGGTGGAGGTGCTGGCCGACCACCCGGGCGAGCTGGTGCGCACCGACA GCCCCAACTTCCTCTGCTCCGTGCTGCCTACGCACTGGCGCTGCAACAAGACCCTGCCCATCGCTTTCAAGGTGGTGGCCCTAGGGGATG TTCCAGATGGCACTCTGGTCACTGTGATGGCTGGCAATGATGAAAACTACTCGGCTGAGCTGAGAAATGCTACCGCAGCCATGAAGAACC AGGTTGCAAGATTTAATGACCTCAGGTTTGTCGGTCGAAGTGGAAGAGGGAAAAGCTTCACTCTGACCATCACTGTCTTCACAAACCCAC CGCAAGTCGCCACCTACCACAGAGCCATCAAAATCACAGTGGATGGGCCCCGAGAACCTCGAAATACAAGGCAGATCCAACCATCCCCAC CGTGGTCCTACGATCAGTCCTACCAATACCTGGGATCCATTGCCTCTCCTTCTGTGCACCCAGCAACGCCCATTTCACCTGGACGTGCCA GCGGCATGACAACCCTCTCTGCAGAACTTTCCAGTCGACTCTCAACCCTAGGTGATGGCATCGCTCCTCCACAGAAAGTTCTTTTCCCAT CTGAGAAGATTTGTCTTAAGTGGCAACAAACTCATAGAGTTGGAGCTGGGCTCCAGAATTTGGGCAATACCTGTTTTGCCAATGCAGCAC TGCAGTGTTTAACCTACACACCACCTCTTGCCAATTACATGCTATCACATGAACACTCCAAAACATGTCATGCAGAAGGCTTTTGTATGA TGTGTACAATGCAAGCACATATTACCCAGGCACTCAGTAATCCTGGGGACGTTATTAAACCAATGTTTGTCATCAATGAGATGCGGCGTA TAGCTAGGCACTTCCGTTTTGGAAACCAAGAAGATGCCCATGAATTCCTTCAATACACTGTTGATGCTATGCAGAAAGCATGCTTGAATG GCAGCAATAAATTAGACAGACACACCCAGGCCACCACTCTTGTTTGTCAGATATTTGGAGGATACCTAAGATCTAGAGTCAAATGTTTAA ATTGCAAGGGCGTTTCAGATACTTTTGATCCATATCTTGATATAACATTGGAGATAAAGGCTGCTCAGAGTGTCAACAAGGCATTGGAGC AGTTTGTGAAGCCGGAACAGCTTGATGGAGAAAACTCGTACAAGTGCAGCAAGTGTAAAAAGATGGTTCCAGCTTCAAAGAGGTTCACTA TCCATAGATCCTCTAATGTTCTTACACTTTCTCTGAAACGTTTTGCAAATTTTACCGGTGGAAAAATTGCTAAGGATGTGAAATACCCTG AGTATCTTGATATTCGGCCATATATGTCTCAACCCAACGGAGAGCCAATTGTCTACGTCTTGTATGCAGTGCTGGTCCACACTGGTTTTA ATTGCCATGCTGGCCATTACTTCTGCTACATAAAAGCTAGCAATGGCCTCTGGTATCAAATGAATGACTCCATTGTATCTACCAGTGATA TTAGATCGGTACTCAGCCAACAAGCCTATGTGCTCTTTTATATCAGGTCCCATGATGTGAAAAATGGAGGTGAACTTACTCATCCCACCC ATAGCCCCGGCCAGTCCTCTCCCCGCCCCGTCATCAGTCAGCGGGTTGTCACCAACAAACAGGCTGCGCCAGGCTTTATCGGACCACAGC TTCCCTCTCACATGATAAAGAATCCACCTCACTTAAATGGGACTGGACCATTGAAAGACACGCCAAGCAGTTCCATGTCGAGTCCTAACG GGAATTCCAGTGTCAACAGGGCTAGTCCTGTTAATGCTTCAGCTTCTGTCCAAAACTGGTCAGTTAATAGGTCCTCAGTGATCCCAGAAC ATCCTAAGAAACAAAAAATTACAATCAGTATTCACAACAAGTTGCCTGTTCGCCAGTGTCAGTCTCAACCTAACCTTCATAGTAATTCTT TGGAGAACCCTACCAAGCCCGTTCCCTCTTCTACCATTACCAATTCTGCAGTACAGTCTACCTCGAACGCATCTACGATGTCAGTTTCTA GTAAAGTAACAAAACCGATCCCCCGCAGTGAATCCTGCTCCCAGCCCGTGATGAATGGCAAATCCAAGCTGAACTCCAGCGTGCTGGTGC CCTATGGCGCCGAGTCCTCTGAGGACTCTGACGAGGAGTCAAAGGGGCTGGGCAAGGAGAATGGGATTGGTACGATTGTGAGCTCCCACT CTCCCGGCCAAGATGCCGAAGATGAGGAGGCCACTCCGCACGAGCTTCAAGAACCCATGACCCTAAACGGTGCTAATAGTGCAGACAGCG ACAGTGACCCGAAAGAAAACGGCCTAGCGCCTGATGGTGCCAGCTGCCAAGGCCAGCCTGCCCTGCACTCAGAAAATCCCTTTGCTAAGG CAAACGGTCTTCCTGGAAAGTTGATGCCTGCTCCTTTGCTGTCTCTCCCAGAAGACAAAATCTTAGAGACCTTCAGGCTTAGCAACAAAC TGAAAGGCTCGACGGATGAAATGAGTGCACCTGGAGCAGAGAGGGGCCCTCCCGAGGACCGCGACGCCGAGCCTCAGCCTGGCAGCCCCG CCGCCGAATCCCTGGAGGAGCCAGATGCGGCCGCCGGCCTCAGCAGCACCAAGAAGGCTCCGCCGCCCCGCGATCCCGGCACCCCCGCTA CCAAAGAAGGCGCCTGGGAGGCCATGGCCGTCGCCCCCGAGGAGCCTCCGCCCAGCGCCGGCGAGGACATCGTGGGGGACACAGCACCCC CTGACCTGTGTGATCCCGGGAGCTTAACAGGCGATGCGAGCCCGTTGTCCCAGGACGCAAAGGGGATGATCGCGGAGGGCCCGCGGGACT CGGCGTTGGCGGAAGCCCCGGAAGGGTTGAGTCCGGCTCCGCCTGCGCGGTCGGAGGAGCCCTGCGAGCAGCCACTCCTTGTTCACCCCA GCGGGGACCACGCCCGGGACGCTCAGGACCCATCCCAGAGCTTGGGCGCACCCGAGGCCGCAGAGCGGCCGCCAGCTCCTGTGCTGGACA TGGCCCCGGCCGGTCACCCGGAAGGGGACGCTGAGCCTAGCCCCGGCGAGAGGGTCGAGGACGCCGCGGCGCCGAAAGCCCCAGGCCCTT CCCCAGCGAAGGAGAAAATCGGCAGCCTCAGAAAGGTGGACCGAGGCCACTACCGCAGCCGGAGAGAGCGCTCGTCCAGCGGGGAGCCCG CCAGAGAGAGCAGGAGCAAGACTGAGGGCCACCGTCACCGGCGGCGCCGCACCTGCCCCCGGGAGCGCGACCGCCAGGACCGCCACGCCC CGGAGCACCACCCCGGCCACGGCGACAGGCTCAGCCCTGGCGAGCGCCGCTCTCTGGGCAGGTGCAGTCACCACCACTCCCGACACCGGA GCGGGGTGGAGCTGGACTGGGTCAGACACCACTACACCGAGGGCGAGCGTGGCTGGGGCCGGGAGAAGTTCTACCCCGACAGGCCGCGCT GGGACAGGTGCCGGTACTACCATGACAGGTACGCCCTGTACGCTGCCCGGGACTGGAAGCCCTTCCACGGCGGCCGCGAGCACGAGCGGG CCGGGCTGCACGAGCGGCCGCACAAGGACCACAACCGGGGCCGTAGGGGCTGCGAGCCGGCCCGGGAGAGGGAGCGGCACCGCCCCAGCA GCCCCCGCGCAGGCGCGCCCCACGCCCTCGCCCCGCACCCCGACCGCTTCTCCCACGACAGAACTGCACTTGTAGCCGGAGACAACTGTA ACCTCTCTGATCGGTTTCACGAACACGAAAATGGAAAGTCCCGGAAACGGAGACACGACAGTGTGGAGAACAGTGACAGTCATGTTGAAA AGAAAGCCCGGAGGAGCGAACAGAAGGATCCTCTAGAAGAGCCTAAAGCAAAGAAGCACAAAAAATCAAAGAAGAAAAAGAAATCCAAAG ACAAACACCGAGACCGCGACTCCAGGCATCAGCAGGACTCAGACCTCTCAGCAGCGTGCTCTGACGCTGACCTCCACAGACACAAAAAAA AGAAGAAGAAAAAGAAGAGACATTCAAGAAAATCAGAGGACTTTGTTAAAGATTCAGAACTGCACTTACCCAGGGTCACCAGCTTGGAGA CTGTCGCCCAGTTCCGGAGAGCCCAGGGTGGCTTTCCTCTCTCTGGTGGCCCGCCTCTGGAAGGCGTCGGACCTTTCCGTGAGAAAACGA AACACTTACGGATGGAAAGCAGGGATGACAGGTGTCGTCTCTTTGAGTATGGCCAGGGTGATTGAAAACTCAGCCTCAAAACAAAAAATT CACTAGTTATGATTCAACGCGTTCAACAGAAGCCATCCCCAGCCCAGCTTAAATTATAAAGATAGACAATAACTCTGTTCCAATCTGCGT GGTGCTTCTTTAGTAAATACTGTACAGATTTTACCATGGAGAACTTTTTTTTTAGTTTTTACCTTTTCTTAATTACCCTTATTCCGAATG GACGAACACTTTCTACCACTGCTGACCATTGTAAAATACCGTGTATATAAATCCCATTGAAATAATGCCCTGGAATAGAACATCTCAAAT GCTGCTTAATTACAGACTCAGGTCGATTACTTGTATTTCATGTAATGTTCCTCCAAGTTAGACATCTGGTGCAAGACCAACCGGGAGACC ATGGAATTGTCAAAAGTACAAACTGACAGTGTGTATATTTAATTTAAAGACTTATTTAAAAACTCACAAGCTCTCACCTAGACTTTGGAG AGCAGTCTGTTTTCTGTAATGTCTGATACTAGAAACTAATTTGCTTATTTTAGTTGTATTCAAGATTTGAAGATGTATTTTATAGACAAG TTCTGTTTTTGAACTTTGTGGAACTGTTCCAATCAATCAATTTCCCAGTTATGATGAGTATTTACATTATGAATGTATAACCCAGACATG ATTTGTAAAGCCGACAGTATGTTTCTATTACACAACACTTTTTGATACAGCGTCTCTTGTCTTCACTGATACTGGAGTCTCCGTTGTCTG CTTGGTCCCTTCGAGTTTCTAGTTACAGACACAATCATACTGTGATTTTATTTTTAATATGGATATGCTATCAAACTGTGATACACTTAT AATTCACTGGTCCTGCATCAGGAGATGGAGTGGGGAAAACTGTATTTAATACAGTTTGTATCTGAATAATCTGTATGGTTTATACAGTTT GTGTTGTTCAGAGATGTTTAAAGTTTGATCTTTGTTTTTCTAAAGATTAAAAAAGCACTTGCCCCACTGTAAATATACAGCATGTAAAAT >78697_78697_4_RUNX1-USP42_RUNX1_chr21_36171597_ENST00000399240_USP42_chr7_6154953_ENST00000306177_length(amino acids)=1467AA_BP=225 MRIPVDASTSRRFTPPSTALSPGKMSEALPLGAPDAGAALAGKLRSGDRSMVEVLADHPGELVRTDSPNFLCSVLPTHWRCNKTLPIAFK VVALGDVPDGTLVTVMAGNDENYSAELRNATAAMKNQVARFNDLRFVGRSGRGKSFTLTITVFTNPPQVATYHRAIKITVDGPREPRNTR QIQPSPPWSYDQSYQYLGSIASPSVHPATPISPGRASGMTTLSAELSSRLSTLGDGIAPPQKVLFPSEKICLKWQQTHRVGAGLQNLGNT CFANAALQCLTYTPPLANYMLSHEHSKTCHAEGFCMMCTMQAHITQALSNPGDVIKPMFVINEMRRIARHFRFGNQEDAHEFLQYTVDAM QKACLNGSNKLDRHTQATTLVCQIFGGYLRSRVKCLNCKGVSDTFDPYLDITLEIKAAQSVNKALEQFVKPEQLDGENSYKCSKCKKMVP ASKRFTIHRSSNVLTLSLKRFANFTGGKIAKDVKYPEYLDIRPYMSQPNGEPIVYVLYAVLVHTGFNCHAGHYFCYIKASNGLWYQMNDS IVSTSDIRSVLSQQAYVLFYIRSHDVKNGGELTHPTHSPGQSSPRPVISQRVVTNKQAAPGFIGPQLPSHMIKNPPHLNGTGPLKDTPSS SMSSPNGNSSVNRASPVNASASVQNWSVNRSSVIPEHPKKQKITISIHNKLPVRQCQSQPNLHSNSLENPTKPVPSSTITNSAVQSTSNA STMSVSSKVTKPIPRSESCSQPVMNGKSKLNSSVLVPYGAESSEDSDEESKGLGKENGIGTIVSSHSPGQDAEDEEATPHELQEPMTLNG ANSADSDSDPKENGLAPDGASCQGQPALHSENPFAKANGLPGKLMPAPLLSLPEDKILETFRLSNKLKGSTDEMSAPGAERGPPEDRDAE PQPGSPAAESLEEPDAAAGLSSTKKAPPPRDPGTPATKEGAWEAMAVAPEEPPPSAGEDIVGDTAPPDLCDPGSLTGDASPLSQDAKGMI AEGPRDSALAEAPEGLSPAPPARSEEPCEQPLLVHPSGDHARDAQDPSQSLGAPEAAERPPAPVLDMAPAGHPEGDAEPSPGERVEDAAA PKAPGPSPAKEKIGSLRKVDRGHYRSRRERSSSGEPARESRSKTEGHRHRRRRTCPRERDRQDRHAPEHHPGHGDRLSPGERRSLGRCSH HHSRHRSGVELDWVRHHYTEGERGWGREKFYPDRPRWDRCRYYHDRYALYAARDWKPFHGGREHERAGLHERPHKDHNRGRRGCEPARER ERHRPSSPRAGAPHALAPHPDRFSHDRTALVAGDNCNLSDRFHEHENGKSRKRRHDSVENSDSHVEKKARRSEQKDPLEEPKAKKHKKSK KKKKSKDKHRDRDSRHQQDSDLSAACSDADLHRHKKKKKKKKRHSRKSEDFVKDSELHLPRVTSLETVAQFRRAQGGFPLSGGPPLEGVG -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for RUNX1-USP42 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for RUNX1-USP42 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for RUNX1-USP42 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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