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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:ATP2B4-NFASC (FusionGDB2 ID:7871)

Fusion Gene Summary for ATP2B4-NFASC

Fusion gene summary

Fusion gene information	Fusion gene name: ATP2B4-NFASC
	Fusion gene ID: 7871
		Hgene	Tgene
	Gene symbol	ATP2B4	NFASC
	Gene ID	493	23114
	Gene name	ATPase plasma membrane Ca2+ transporting 4	neurofascin
	Synonyms	ATP2B2\|MXRA1\|PMCA4\|PMCA4b\|PMCA4x	NEDCPMD\|NF\|NRCAML
	Cytomap	1q32.1	1q32.1
	Type of gene	protein-coding	protein-coding
	Description	plasma membrane calcium-transporting ATPase 4ATPase, Ca++ transporting, plasma membrane 4matrix-remodeling-associated protein 1sarcolemmal calcium pump	neurofascinneurofascin homologneurofascin isoform 140
	Modification date	20200327	20200313
	UniProtAcc	P23634	O94856
	Ensembl transtripts involved in fusion gene	ENST00000357681, ENST00000367218, ENST00000367219, ENST00000391954, ENST00000341360, ENST00000466407,	ENST00000338515, ENST00000338586, ENST00000339876, ENST00000360049, ENST00000367169, ENST00000367170, ENST00000367171, ENST00000367172, ENST00000401399, ENST00000403080, ENST00000404076, ENST00000539706, ENST00000404907, ENST00000495396, ENST00000513543,
Fusion gene scores	* DoF score	14 X 5 X 8=560	6 X 5 X 4=120
	# samples	17	7
	** MAII score	log2(17/560*10)=-1.71989208080726 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(7/120*10)=-0.777607578663552 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: ATP2B4 [Title/Abstract] AND NFASC [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	ATP2B4(203596347)-NFASC(204889760), # samples:2 NFASC(204797910)-ATP2B4(203667285), # samples:2
Anticipated loss of major functional domain due to fusion event.	NFASC-ATP2B4 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF. NFASC-ATP2B4 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	ATP2B4	GO:0006874	cellular calcium ion homeostasis	19278978\|25798335
Hgene	ATP2B4	GO:0010629	negative regulation of gene expression	25147342
Hgene	ATP2B4	GO:0010751	negative regulation of nitric oxide mediated signal transduction	19278978
Hgene	ATP2B4	GO:0016525	negative regulation of angiogenesis	25147342
Hgene	ATP2B4	GO:0033138	positive regulation of peptidyl-serine phosphorylation	19278978
Hgene	ATP2B4	GO:0043537	negative regulation of blood vessel endothelial cell migration	25147342
Hgene	ATP2B4	GO:0045019	negative regulation of nitric oxide biosynthetic process	11591728\|19278978
Hgene	ATP2B4	GO:0051001	negative regulation of nitric-oxide synthase activity	11591728\|17242280\|19278978\|19287093
Hgene	ATP2B4	GO:0070885	negative regulation of calcineurin-NFAT signaling cascade	19287093\|25147342
Hgene	ATP2B4	GO:0071872	cellular response to epinephrine stimulus	19278978
Hgene	ATP2B4	GO:0098736	negative regulation of the force of heart contraction	17242280
Hgene	ATP2B4	GO:0140199	negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process	17242280
Hgene	ATP2B4	GO:1900082	negative regulation of arginine catabolic process	19278978
Hgene	ATP2B4	GO:1901660	calcium ion export	25798335
Hgene	ATP2B4	GO:1902548	negative regulation of cellular response to vascular endothelial growth factor stimulus	25147342
Hgene	ATP2B4	GO:1903078	positive regulation of protein localization to plasma membrane	15955804
Hgene	ATP2B4	GO:1903249	negative regulation of citrulline biosynthetic process	19278978
Hgene	ATP2B4	GO:2000481	positive regulation of cAMP-dependent protein kinase activity	19278978

Fusion gene breakpoints across ATP2B4 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across NFASC (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	GBM	TCGA-06-5411-01A	ATP2B4	chr1	203596347	-	NFASC	chr1	204889760	+
ChimerDB4	GBM	TCGA-06-5411-01A	ATP2B4	chr1	203596347	+	NFASC	chr1	204889760	+
ChimerDB4	GBM	TCGA-06-5411	ATP2B4	chr1	203596347	+	NFASC	chr1	204889759	+

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Fusion Gene ORF analysis for ATP2B4-NFASC

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5UTR-5UTR	ENST00000357681	ENST00000338515	ATP2B4	chr1	203596347	+	NFASC	chr1	204889760	+
5UTR-5UTR	ENST00000357681	ENST00000338515	ATP2B4	chr1	203596347	+	NFASC	chr1	204889759	+
5UTR-5UTR	ENST00000357681	ENST00000338586	ATP2B4	chr1	203596347	+	NFASC	chr1	204889760	+
5UTR-5UTR	ENST00000357681	ENST00000338586	ATP2B4	chr1	203596347	+	NFASC	chr1	204889759	+
5UTR-5UTR	ENST00000357681	ENST00000339876	ATP2B4	chr1	203596347	+	NFASC	chr1	204889760	+
5UTR-5UTR	ENST00000357681	ENST00000339876	ATP2B4	chr1	203596347	+	NFASC	chr1	204889759	+
5UTR-5UTR	ENST00000357681	ENST00000360049	ATP2B4	chr1	203596347	+	NFASC	chr1	204889760	+
5UTR-5UTR	ENST00000357681	ENST00000360049	ATP2B4	chr1	203596347	+	NFASC	chr1	204889759	+
5UTR-5UTR	ENST00000357681	ENST00000367169	ATP2B4	chr1	203596347	+	NFASC	chr1	204889760	+
5UTR-5UTR	ENST00000357681	ENST00000367169	ATP2B4	chr1	203596347	+	NFASC	chr1	204889759	+
5UTR-5UTR	ENST00000357681	ENST00000367170	ATP2B4	chr1	203596347	+	NFASC	chr1	204889760	+
5UTR-5UTR	ENST00000357681	ENST00000367170	ATP2B4	chr1	203596347	+	NFASC	chr1	204889759	+
5UTR-5UTR	ENST00000357681	ENST00000367171	ATP2B4	chr1	203596347	+	NFASC	chr1	204889760	+
5UTR-5UTR	ENST00000357681	ENST00000367171	ATP2B4	chr1	203596347	+	NFASC	chr1	204889759	+
5UTR-5UTR	ENST00000357681	ENST00000367172	ATP2B4	chr1	203596347	+	NFASC	chr1	204889760	+
5UTR-5UTR	ENST00000357681	ENST00000367172	ATP2B4	chr1	203596347	+	NFASC	chr1	204889759	+
5UTR-5UTR	ENST00000357681	ENST00000401399	ATP2B4	chr1	203596347	+	NFASC	chr1	204889760	+
5UTR-5UTR	ENST00000357681	ENST00000401399	ATP2B4	chr1	203596347	+	NFASC	chr1	204889759	+
5UTR-5UTR	ENST00000357681	ENST00000403080	ATP2B4	chr1	203596347	+	NFASC	chr1	204889760	+
5UTR-5UTR	ENST00000357681	ENST00000403080	ATP2B4	chr1	203596347	+	NFASC	chr1	204889759	+
5UTR-5UTR	ENST00000357681	ENST00000404076	ATP2B4	chr1	203596347	+	NFASC	chr1	204889760	+
5UTR-5UTR	ENST00000357681	ENST00000404076	ATP2B4	chr1	203596347	+	NFASC	chr1	204889759	+
5UTR-5UTR	ENST00000357681	ENST00000539706	ATP2B4	chr1	203596347	+	NFASC	chr1	204889760	+
5UTR-5UTR	ENST00000357681	ENST00000539706	ATP2B4	chr1	203596347	+	NFASC	chr1	204889759	+
5UTR-5UTR	ENST00000367218	ENST00000338515	ATP2B4	chr1	203596347	+	NFASC	chr1	204889760	+
5UTR-5UTR	ENST00000367218	ENST00000338515	ATP2B4	chr1	203596347	+	NFASC	chr1	204889759	+
5UTR-5UTR	ENST00000367218	ENST00000338586	ATP2B4	chr1	203596347	+	NFASC	chr1	204889760	+
5UTR-5UTR	ENST00000367218	ENST00000338586	ATP2B4	chr1	203596347	+	NFASC	chr1	204889759	+
5UTR-5UTR	ENST00000367218	ENST00000339876	ATP2B4	chr1	203596347	+	NFASC	chr1	204889760	+
5UTR-5UTR	ENST00000367218	ENST00000339876	ATP2B4	chr1	203596347	+	NFASC	chr1	204889759	+
5UTR-5UTR	ENST00000367218	ENST00000360049	ATP2B4	chr1	203596347	+	NFASC	chr1	204889760	+
5UTR-5UTR	ENST00000367218	ENST00000360049	ATP2B4	chr1	203596347	+	NFASC	chr1	204889759	+
5UTR-5UTR	ENST00000367218	ENST00000367169	ATP2B4	chr1	203596347	+	NFASC	chr1	204889760	+
5UTR-5UTR	ENST00000367218	ENST00000367169	ATP2B4	chr1	203596347	+	NFASC	chr1	204889759	+
5UTR-5UTR	ENST00000367218	ENST00000367170	ATP2B4	chr1	203596347	+	NFASC	chr1	204889760	+
5UTR-5UTR	ENST00000367218	ENST00000367170	ATP2B4	chr1	203596347	+	NFASC	chr1	204889759	+
5UTR-5UTR	ENST00000367218	ENST00000367171	ATP2B4	chr1	203596347	+	NFASC	chr1	204889760	+
5UTR-5UTR	ENST00000367218	ENST00000367171	ATP2B4	chr1	203596347	+	NFASC	chr1	204889759	+
5UTR-5UTR	ENST00000367218	ENST00000367172	ATP2B4	chr1	203596347	+	NFASC	chr1	204889760	+
5UTR-5UTR	ENST00000367218	ENST00000367172	ATP2B4	chr1	203596347	+	NFASC	chr1	204889759	+
5UTR-5UTR	ENST00000367218	ENST00000401399	ATP2B4	chr1	203596347	+	NFASC	chr1	204889760	+
5UTR-5UTR	ENST00000367218	ENST00000401399	ATP2B4	chr1	203596347	+	NFASC	chr1	204889759	+
5UTR-5UTR	ENST00000367218	ENST00000403080	ATP2B4	chr1	203596347	+	NFASC	chr1	204889760	+
5UTR-5UTR	ENST00000367218	ENST00000403080	ATP2B4	chr1	203596347	+	NFASC	chr1	204889759	+
5UTR-5UTR	ENST00000367218	ENST00000404076	ATP2B4	chr1	203596347	+	NFASC	chr1	204889760	+
5UTR-5UTR	ENST00000367218	ENST00000404076	ATP2B4	chr1	203596347	+	NFASC	chr1	204889759	+
5UTR-5UTR	ENST00000367218	ENST00000539706	ATP2B4	chr1	203596347	+	NFASC	chr1	204889760	+
5UTR-5UTR	ENST00000367218	ENST00000539706	ATP2B4	chr1	203596347	+	NFASC	chr1	204889759	+
5UTR-5UTR	ENST00000367219	ENST00000338515	ATP2B4	chr1	203596347	+	NFASC	chr1	204889760	+
5UTR-5UTR	ENST00000367219	ENST00000338515	ATP2B4	chr1	203596347	+	NFASC	chr1	204889759	+
5UTR-5UTR	ENST00000367219	ENST00000338586	ATP2B4	chr1	203596347	+	NFASC	chr1	204889760	+
5UTR-5UTR	ENST00000367219	ENST00000338586	ATP2B4	chr1	203596347	+	NFASC	chr1	204889759	+
5UTR-5UTR	ENST00000367219	ENST00000339876	ATP2B4	chr1	203596347	+	NFASC	chr1	204889760	+
5UTR-5UTR	ENST00000367219	ENST00000339876	ATP2B4	chr1	203596347	+	NFASC	chr1	204889759	+
5UTR-5UTR	ENST00000367219	ENST00000360049	ATP2B4	chr1	203596347	+	NFASC	chr1	204889760	+
5UTR-5UTR	ENST00000367219	ENST00000360049	ATP2B4	chr1	203596347	+	NFASC	chr1	204889759	+
5UTR-5UTR	ENST00000367219	ENST00000367169	ATP2B4	chr1	203596347	+	NFASC	chr1	204889760	+
5UTR-5UTR	ENST00000367219	ENST00000367169	ATP2B4	chr1	203596347	+	NFASC	chr1	204889759	+
5UTR-5UTR	ENST00000367219	ENST00000367170	ATP2B4	chr1	203596347	+	NFASC	chr1	204889760	+
5UTR-5UTR	ENST00000367219	ENST00000367170	ATP2B4	chr1	203596347	+	NFASC	chr1	204889759	+
5UTR-5UTR	ENST00000367219	ENST00000367171	ATP2B4	chr1	203596347	+	NFASC	chr1	204889760	+
5UTR-5UTR	ENST00000367219	ENST00000367171	ATP2B4	chr1	203596347	+	NFASC	chr1	204889759	+
5UTR-5UTR	ENST00000367219	ENST00000367172	ATP2B4	chr1	203596347	+	NFASC	chr1	204889760	+
5UTR-5UTR	ENST00000367219	ENST00000367172	ATP2B4	chr1	203596347	+	NFASC	chr1	204889759	+
5UTR-5UTR	ENST00000367219	ENST00000401399	ATP2B4	chr1	203596347	+	NFASC	chr1	204889760	+
5UTR-5UTR	ENST00000367219	ENST00000401399	ATP2B4	chr1	203596347	+	NFASC	chr1	204889759	+
5UTR-5UTR	ENST00000367219	ENST00000403080	ATP2B4	chr1	203596347	+	NFASC	chr1	204889760	+
5UTR-5UTR	ENST00000367219	ENST00000403080	ATP2B4	chr1	203596347	+	NFASC	chr1	204889759	+
5UTR-5UTR	ENST00000367219	ENST00000404076	ATP2B4	chr1	203596347	+	NFASC	chr1	204889760	+
5UTR-5UTR	ENST00000367219	ENST00000404076	ATP2B4	chr1	203596347	+	NFASC	chr1	204889759	+
5UTR-5UTR	ENST00000367219	ENST00000539706	ATP2B4	chr1	203596347	+	NFASC	chr1	204889760	+
5UTR-5UTR	ENST00000367219	ENST00000539706	ATP2B4	chr1	203596347	+	NFASC	chr1	204889759	+
5UTR-5UTR	ENST00000391954	ENST00000338515	ATP2B4	chr1	203596347	+	NFASC	chr1	204889760	+
5UTR-5UTR	ENST00000391954	ENST00000338515	ATP2B4	chr1	203596347	+	NFASC	chr1	204889759	+
5UTR-5UTR	ENST00000391954	ENST00000338586	ATP2B4	chr1	203596347	+	NFASC	chr1	204889760	+
5UTR-5UTR	ENST00000391954	ENST00000338586	ATP2B4	chr1	203596347	+	NFASC	chr1	204889759	+
5UTR-5UTR	ENST00000391954	ENST00000339876	ATP2B4	chr1	203596347	+	NFASC	chr1	204889760	+
5UTR-5UTR	ENST00000391954	ENST00000339876	ATP2B4	chr1	203596347	+	NFASC	chr1	204889759	+
5UTR-5UTR	ENST00000391954	ENST00000360049	ATP2B4	chr1	203596347	+	NFASC	chr1	204889760	+
5UTR-5UTR	ENST00000391954	ENST00000360049	ATP2B4	chr1	203596347	+	NFASC	chr1	204889759	+
5UTR-5UTR	ENST00000391954	ENST00000367169	ATP2B4	chr1	203596347	+	NFASC	chr1	204889760	+
5UTR-5UTR	ENST00000391954	ENST00000367169	ATP2B4	chr1	203596347	+	NFASC	chr1	204889759	+
5UTR-5UTR	ENST00000391954	ENST00000367170	ATP2B4	chr1	203596347	+	NFASC	chr1	204889760	+
5UTR-5UTR	ENST00000391954	ENST00000367170	ATP2B4	chr1	203596347	+	NFASC	chr1	204889759	+
5UTR-5UTR	ENST00000391954	ENST00000367171	ATP2B4	chr1	203596347	+	NFASC	chr1	204889760	+
5UTR-5UTR	ENST00000391954	ENST00000367171	ATP2B4	chr1	203596347	+	NFASC	chr1	204889759	+
5UTR-5UTR	ENST00000391954	ENST00000367172	ATP2B4	chr1	203596347	+	NFASC	chr1	204889760	+
5UTR-5UTR	ENST00000391954	ENST00000367172	ATP2B4	chr1	203596347	+	NFASC	chr1	204889759	+
5UTR-5UTR	ENST00000391954	ENST00000401399	ATP2B4	chr1	203596347	+	NFASC	chr1	204889760	+
5UTR-5UTR	ENST00000391954	ENST00000401399	ATP2B4	chr1	203596347	+	NFASC	chr1	204889759	+
5UTR-5UTR	ENST00000391954	ENST00000403080	ATP2B4	chr1	203596347	+	NFASC	chr1	204889760	+
5UTR-5UTR	ENST00000391954	ENST00000403080	ATP2B4	chr1	203596347	+	NFASC	chr1	204889759	+
5UTR-5UTR	ENST00000391954	ENST00000404076	ATP2B4	chr1	203596347	+	NFASC	chr1	204889760	+
5UTR-5UTR	ENST00000391954	ENST00000404076	ATP2B4	chr1	203596347	+	NFASC	chr1	204889759	+
5UTR-5UTR	ENST00000391954	ENST00000539706	ATP2B4	chr1	203596347	+	NFASC	chr1	204889760	+
5UTR-5UTR	ENST00000391954	ENST00000539706	ATP2B4	chr1	203596347	+	NFASC	chr1	204889759	+
5UTR-intron	ENST00000357681	ENST00000404907	ATP2B4	chr1	203596347	+	NFASC	chr1	204889760	+
5UTR-intron	ENST00000357681	ENST00000404907	ATP2B4	chr1	203596347	+	NFASC	chr1	204889759	+
5UTR-intron	ENST00000357681	ENST00000495396	ATP2B4	chr1	203596347	+	NFASC	chr1	204889760	+
5UTR-intron	ENST00000357681	ENST00000495396	ATP2B4	chr1	203596347	+	NFASC	chr1	204889759	+
5UTR-intron	ENST00000357681	ENST00000513543	ATP2B4	chr1	203596347	+	NFASC	chr1	204889760	+
5UTR-intron	ENST00000357681	ENST00000513543	ATP2B4	chr1	203596347	+	NFASC	chr1	204889759	+
5UTR-intron	ENST00000367218	ENST00000404907	ATP2B4	chr1	203596347	+	NFASC	chr1	204889760	+
5UTR-intron	ENST00000367218	ENST00000404907	ATP2B4	chr1	203596347	+	NFASC	chr1	204889759	+
5UTR-intron	ENST00000367218	ENST00000495396	ATP2B4	chr1	203596347	+	NFASC	chr1	204889760	+
5UTR-intron	ENST00000367218	ENST00000495396	ATP2B4	chr1	203596347	+	NFASC	chr1	204889759	+
5UTR-intron	ENST00000367218	ENST00000513543	ATP2B4	chr1	203596347	+	NFASC	chr1	204889760	+
5UTR-intron	ENST00000367218	ENST00000513543	ATP2B4	chr1	203596347	+	NFASC	chr1	204889759	+
5UTR-intron	ENST00000367219	ENST00000404907	ATP2B4	chr1	203596347	+	NFASC	chr1	204889760	+
5UTR-intron	ENST00000367219	ENST00000404907	ATP2B4	chr1	203596347	+	NFASC	chr1	204889759	+
5UTR-intron	ENST00000367219	ENST00000495396	ATP2B4	chr1	203596347	+	NFASC	chr1	204889760	+
5UTR-intron	ENST00000367219	ENST00000495396	ATP2B4	chr1	203596347	+	NFASC	chr1	204889759	+
5UTR-intron	ENST00000367219	ENST00000513543	ATP2B4	chr1	203596347	+	NFASC	chr1	204889760	+
5UTR-intron	ENST00000367219	ENST00000513543	ATP2B4	chr1	203596347	+	NFASC	chr1	204889759	+
5UTR-intron	ENST00000391954	ENST00000404907	ATP2B4	chr1	203596347	+	NFASC	chr1	204889760	+
5UTR-intron	ENST00000391954	ENST00000404907	ATP2B4	chr1	203596347	+	NFASC	chr1	204889759	+
5UTR-intron	ENST00000391954	ENST00000495396	ATP2B4	chr1	203596347	+	NFASC	chr1	204889760	+
5UTR-intron	ENST00000391954	ENST00000495396	ATP2B4	chr1	203596347	+	NFASC	chr1	204889759	+
5UTR-intron	ENST00000391954	ENST00000513543	ATP2B4	chr1	203596347	+	NFASC	chr1	204889760	+
5UTR-intron	ENST00000391954	ENST00000513543	ATP2B4	chr1	203596347	+	NFASC	chr1	204889759	+
intron-5UTR	ENST00000341360	ENST00000338515	ATP2B4	chr1	203596347	+	NFASC	chr1	204889760	+
intron-5UTR	ENST00000341360	ENST00000338515	ATP2B4	chr1	203596347	+	NFASC	chr1	204889759	+
intron-5UTR	ENST00000341360	ENST00000338586	ATP2B4	chr1	203596347	+	NFASC	chr1	204889760	+
intron-5UTR	ENST00000341360	ENST00000338586	ATP2B4	chr1	203596347	+	NFASC	chr1	204889759	+
intron-5UTR	ENST00000341360	ENST00000339876	ATP2B4	chr1	203596347	+	NFASC	chr1	204889760	+
intron-5UTR	ENST00000341360	ENST00000339876	ATP2B4	chr1	203596347	+	NFASC	chr1	204889759	+
intron-5UTR	ENST00000341360	ENST00000360049	ATP2B4	chr1	203596347	+	NFASC	chr1	204889760	+
intron-5UTR	ENST00000341360	ENST00000360049	ATP2B4	chr1	203596347	+	NFASC	chr1	204889759	+
intron-5UTR	ENST00000341360	ENST00000367169	ATP2B4	chr1	203596347	+	NFASC	chr1	204889760	+
intron-5UTR	ENST00000341360	ENST00000367169	ATP2B4	chr1	203596347	+	NFASC	chr1	204889759	+
intron-5UTR	ENST00000341360	ENST00000367170	ATP2B4	chr1	203596347	+	NFASC	chr1	204889760	+
intron-5UTR	ENST00000341360	ENST00000367170	ATP2B4	chr1	203596347	+	NFASC	chr1	204889759	+
intron-5UTR	ENST00000341360	ENST00000367171	ATP2B4	chr1	203596347	+	NFASC	chr1	204889760	+
intron-5UTR	ENST00000341360	ENST00000367171	ATP2B4	chr1	203596347	+	NFASC	chr1	204889759	+
intron-5UTR	ENST00000341360	ENST00000367172	ATP2B4	chr1	203596347	+	NFASC	chr1	204889760	+
intron-5UTR	ENST00000341360	ENST00000367172	ATP2B4	chr1	203596347	+	NFASC	chr1	204889759	+
intron-5UTR	ENST00000341360	ENST00000401399	ATP2B4	chr1	203596347	+	NFASC	chr1	204889760	+
intron-5UTR	ENST00000341360	ENST00000401399	ATP2B4	chr1	203596347	+	NFASC	chr1	204889759	+
intron-5UTR	ENST00000341360	ENST00000403080	ATP2B4	chr1	203596347	+	NFASC	chr1	204889760	+
intron-5UTR	ENST00000341360	ENST00000403080	ATP2B4	chr1	203596347	+	NFASC	chr1	204889759	+
intron-5UTR	ENST00000341360	ENST00000404076	ATP2B4	chr1	203596347	+	NFASC	chr1	204889760	+
intron-5UTR	ENST00000341360	ENST00000404076	ATP2B4	chr1	203596347	+	NFASC	chr1	204889759	+
intron-5UTR	ENST00000341360	ENST00000539706	ATP2B4	chr1	203596347	+	NFASC	chr1	204889760	+
intron-5UTR	ENST00000341360	ENST00000539706	ATP2B4	chr1	203596347	+	NFASC	chr1	204889759	+
intron-5UTR	ENST00000466407	ENST00000338515	ATP2B4	chr1	203596347	+	NFASC	chr1	204889760	+
intron-5UTR	ENST00000466407	ENST00000338515	ATP2B4	chr1	203596347	+	NFASC	chr1	204889759	+
intron-5UTR	ENST00000466407	ENST00000338586	ATP2B4	chr1	203596347	+	NFASC	chr1	204889760	+
intron-5UTR	ENST00000466407	ENST00000338586	ATP2B4	chr1	203596347	+	NFASC	chr1	204889759	+
intron-5UTR	ENST00000466407	ENST00000339876	ATP2B4	chr1	203596347	+	NFASC	chr1	204889760	+
intron-5UTR	ENST00000466407	ENST00000339876	ATP2B4	chr1	203596347	+	NFASC	chr1	204889759	+
intron-5UTR	ENST00000466407	ENST00000360049	ATP2B4	chr1	203596347	+	NFASC	chr1	204889760	+
intron-5UTR	ENST00000466407	ENST00000360049	ATP2B4	chr1	203596347	+	NFASC	chr1	204889759	+
intron-5UTR	ENST00000466407	ENST00000367169	ATP2B4	chr1	203596347	+	NFASC	chr1	204889760	+
intron-5UTR	ENST00000466407	ENST00000367169	ATP2B4	chr1	203596347	+	NFASC	chr1	204889759	+
intron-5UTR	ENST00000466407	ENST00000367170	ATP2B4	chr1	203596347	+	NFASC	chr1	204889760	+
intron-5UTR	ENST00000466407	ENST00000367170	ATP2B4	chr1	203596347	+	NFASC	chr1	204889759	+
intron-5UTR	ENST00000466407	ENST00000367171	ATP2B4	chr1	203596347	+	NFASC	chr1	204889760	+
intron-5UTR	ENST00000466407	ENST00000367171	ATP2B4	chr1	203596347	+	NFASC	chr1	204889759	+
intron-5UTR	ENST00000466407	ENST00000367172	ATP2B4	chr1	203596347	+	NFASC	chr1	204889760	+
intron-5UTR	ENST00000466407	ENST00000367172	ATP2B4	chr1	203596347	+	NFASC	chr1	204889759	+
intron-5UTR	ENST00000466407	ENST00000401399	ATP2B4	chr1	203596347	+	NFASC	chr1	204889760	+
intron-5UTR	ENST00000466407	ENST00000401399	ATP2B4	chr1	203596347	+	NFASC	chr1	204889759	+
intron-5UTR	ENST00000466407	ENST00000403080	ATP2B4	chr1	203596347	+	NFASC	chr1	204889760	+
intron-5UTR	ENST00000466407	ENST00000403080	ATP2B4	chr1	203596347	+	NFASC	chr1	204889759	+
intron-5UTR	ENST00000466407	ENST00000404076	ATP2B4	chr1	203596347	+	NFASC	chr1	204889760	+
intron-5UTR	ENST00000466407	ENST00000404076	ATP2B4	chr1	203596347	+	NFASC	chr1	204889759	+
intron-5UTR	ENST00000466407	ENST00000539706	ATP2B4	chr1	203596347	+	NFASC	chr1	204889760	+
intron-5UTR	ENST00000466407	ENST00000539706	ATP2B4	chr1	203596347	+	NFASC	chr1	204889759	+
intron-intron	ENST00000341360	ENST00000404907	ATP2B4	chr1	203596347	+	NFASC	chr1	204889760	+
intron-intron	ENST00000341360	ENST00000404907	ATP2B4	chr1	203596347	+	NFASC	chr1	204889759	+
intron-intron	ENST00000341360	ENST00000495396	ATP2B4	chr1	203596347	+	NFASC	chr1	204889760	+
intron-intron	ENST00000341360	ENST00000495396	ATP2B4	chr1	203596347	+	NFASC	chr1	204889759	+
intron-intron	ENST00000341360	ENST00000513543	ATP2B4	chr1	203596347	+	NFASC	chr1	204889760	+
intron-intron	ENST00000341360	ENST00000513543	ATP2B4	chr1	203596347	+	NFASC	chr1	204889759	+
intron-intron	ENST00000466407	ENST00000404907	ATP2B4	chr1	203596347	+	NFASC	chr1	204889760	+
intron-intron	ENST00000466407	ENST00000404907	ATP2B4	chr1	203596347	+	NFASC	chr1	204889759	+
intron-intron	ENST00000466407	ENST00000495396	ATP2B4	chr1	203596347	+	NFASC	chr1	204889760	+
intron-intron	ENST00000466407	ENST00000495396	ATP2B4	chr1	203596347	+	NFASC	chr1	204889759	+
intron-intron	ENST00000466407	ENST00000513543	ATP2B4	chr1	203596347	+	NFASC	chr1	204889760	+
intron-intron	ENST00000466407	ENST00000513543	ATP2B4	chr1	203596347	+	NFASC	chr1	204889759	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

No-coding score

Coding score

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Fusion Genomic Features for ATP2B4-NFASC

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
ATP2B4	chr1	203596347	+	NFASC	chr1	204889759	+	0.005099622	0.9949004
ATP2B4	chr1	203596347	+	NFASC	chr1	204889759	+	0.005099622	0.9949004
ATP2B4	chr1	203596347	+	NFASC	chr1	204889759	+	0.005099622	0.9949004
ATP2B4	chr1	203596347	+	NFASC	chr1	204889759	+	0.005099622	0.9949004

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for ATP2B4-NFASC

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:203596347/:204889760)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
ATP2B4 P23634	NFASC O94856
FUNCTION: Calcium/calmodulin-regulated and magnesium-dependent enzyme that catalyzes the hydrolysis of ATP coupled with the transport of calcium out of the cell (PubMed:8530416). By regulating sperm cell calcium homeostasis, may play a role in sperm motility (By similarity). {ECO:0000250\|UniProtKB:Q6Q477, ECO:0000269\|PubMed:8530416}.	FUNCTION: Cell adhesion, ankyrin-binding protein which may be involved in neurite extension, axonal guidance, synaptogenesis, myelination and neuron-glial cell interactions. {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

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Fusion Gene Sequence for ATP2B4-NFASC

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for ATP2B4-NFASC

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for ATP2B4-NFASC

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for ATP2B4-NFASC

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source