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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:RWDD1-CEP85L (FusionGDB2 ID:78746)

Fusion Gene Summary for RWDD1-CEP85L

check button Fusion gene summary
Fusion gene informationFusion gene name: RWDD1-CEP85L
Fusion gene ID: 78746
HgeneTgene
Gene symbol

RWDD1

CEP85L

Gene ID

51389

387119

Gene nameRWD domain containing 1centrosomal protein 85 like
SynonymsCGI-24|PTD013C6orf204|NY-BR-15|bA57K17.2
Cytomap

6q22.1

6q22.31

Type of geneprotein-codingprotein-coding
DescriptionRWD domain-containing protein 1DRG family-regulatory protein 2centrosomal protein of 85 kDa-likecentrosomal protein 85kDa-likeserologically defined breast cancer antigen NY-BR-15
Modification date2020031320200313
UniProtAcc.

Q5SZL2

Ensembl transtripts involved in fusion geneENST00000466444, ENST00000392526, 
ENST00000487832, ENST00000517800, 
ENST00000472713, ENST00000360290, 
ENST00000368488, ENST00000368491, 
ENST00000392500, ENST00000419517, 
Fusion gene scores* DoF score6 X 7 X 5=2105 X 5 X 3=75
# samples 76
** MAII scorelog2(7/210*10)=-1.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(6/75*10)=-0.321928094887362
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: RWDD1 [Title/Abstract] AND CEP85L [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointRWDD1(116906020)-CEP85L(118845083), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across RWDD1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across CEP85L (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SARCTCGA-DX-AATS-01ARWDD1chr6

116906020

+CEP85Lchr6

118845083

-
ChimerDB4SARCTCGA-SG-A6Z7-01ARWDD1chr6

116906020

+CEP85Lchr6

118845083

-


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Fusion Gene ORF analysis for RWDD1-CEP85L

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000466444ENST00000472713RWDD1chr6

116906020

+CEP85Lchr6

118845083

-
5UTR-3CDSENST00000392526ENST00000360290RWDD1chr6

116906020

+CEP85Lchr6

118845083

-
5UTR-3CDSENST00000392526ENST00000368488RWDD1chr6

116906020

+CEP85Lchr6

118845083

-
5UTR-3CDSENST00000392526ENST00000368491RWDD1chr6

116906020

+CEP85Lchr6

118845083

-
5UTR-3CDSENST00000392526ENST00000392500RWDD1chr6

116906020

+CEP85Lchr6

118845083

-
5UTR-3CDSENST00000392526ENST00000419517RWDD1chr6

116906020

+CEP85Lchr6

118845083

-
5UTR-3CDSENST00000487832ENST00000360290RWDD1chr6

116906020

+CEP85Lchr6

118845083

-
5UTR-3CDSENST00000487832ENST00000368488RWDD1chr6

116906020

+CEP85Lchr6

118845083

-
5UTR-3CDSENST00000487832ENST00000368491RWDD1chr6

116906020

+CEP85Lchr6

118845083

-
5UTR-3CDSENST00000487832ENST00000392500RWDD1chr6

116906020

+CEP85Lchr6

118845083

-
5UTR-3CDSENST00000487832ENST00000419517RWDD1chr6

116906020

+CEP85Lchr6

118845083

-
5UTR-intronENST00000392526ENST00000472713RWDD1chr6

116906020

+CEP85Lchr6

118845083

-
5UTR-intronENST00000487832ENST00000472713RWDD1chr6

116906020

+CEP85Lchr6

118845083

-
In-frameENST00000466444ENST00000360290RWDD1chr6

116906020

+CEP85Lchr6

118845083

-
In-frameENST00000466444ENST00000368488RWDD1chr6

116906020

+CEP85Lchr6

118845083

-
In-frameENST00000466444ENST00000368491RWDD1chr6

116906020

+CEP85Lchr6

118845083

-
In-frameENST00000466444ENST00000392500RWDD1chr6

116906020

+CEP85Lchr6

118845083

-
In-frameENST00000466444ENST00000419517RWDD1chr6

116906020

+CEP85Lchr6

118845083

-
intron-3CDSENST00000517800ENST00000360290RWDD1chr6

116906020

+CEP85Lchr6

118845083

-
intron-3CDSENST00000517800ENST00000368488RWDD1chr6

116906020

+CEP85Lchr6

118845083

-
intron-3CDSENST00000517800ENST00000368491RWDD1chr6

116906020

+CEP85Lchr6

118845083

-
intron-3CDSENST00000517800ENST00000392500RWDD1chr6

116906020

+CEP85Lchr6

118845083

-
intron-3CDSENST00000517800ENST00000419517RWDD1chr6

116906020

+CEP85Lchr6

118845083

-
intron-intronENST00000517800ENST00000472713RWDD1chr6

116906020

+CEP85Lchr6

118845083

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000466444RWDD1chr6116906020+ENST00000368491CEP85Lchr6118845083-65174861051883592
ENST00000466444RWDD1chr6116906020+ENST00000368488CEP85Lchr6118845083-65084861051883592
ENST00000466444RWDD1chr6116906020+ENST00000360290CEP85Lchr6118845083-1158486105956283
ENST00000466444RWDD1chr6116906020+ENST00000392500CEP85Lchr6118845083-1158486105956283
ENST00000466444RWDD1chr6116906020+ENST00000419517CEP85Lchr6118845083-957486105956283

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000466444ENST00000368491RWDD1chr6116906020+CEP85Lchr6118845083-7.50E-050.999925
ENST00000466444ENST00000368488RWDD1chr6116906020+CEP85Lchr6118845083-7.52E-050.9999248
ENST00000466444ENST00000360290RWDD1chr6116906020+CEP85Lchr6118845083-0.0009264810.9990735
ENST00000466444ENST00000392500RWDD1chr6116906020+CEP85Lchr6118845083-0.0009264810.9990735
ENST00000466444ENST00000419517RWDD1chr6116906020+CEP85Lchr6118845083-0.0014464520.9985536

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Fusion Genomic Features for RWDD1-CEP85L


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for RWDD1-CEP85L


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr6:116906020/chr6:118845083)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.CEP85L

Q5SZL2

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Plays an essential role in neuronal cell migration. {ECO:0000269|PubMed:32097630}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneCEP85Lchr6:116906020chr6:118845083ENST0000036029026439_682238395.0Coiled coilOntology_term=ECO:0000255
TgeneCEP85Lchr6:116906020chr6:118845083ENST00000368488314439_682343809.0Coiled coilOntology_term=ECO:0000255
TgeneCEP85Lchr6:116906020chr6:118845083ENST00000368491213439_682340806.0Coiled coilOntology_term=ECO:0000255
TgeneCEP85Lchr6:116906020chr6:118845083ENST0000039250048439_682343500.0Coiled coilOntology_term=ECO:0000255
TgeneCEP85Lchr6:116906020chr6:118845083ENST0000041951726439_682340497.0Coiled coilOntology_term=ECO:0000255

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneRWDD1chr6:116906020chr6:118845083ENST00000392526+5910_1140148.0DomainRWD
HgeneRWDD1chr6:116906020chr6:118845083ENST00000466444+3710_11490244.0DomainRWD
HgeneRWDD1chr6:116906020chr6:118845083ENST00000487832+4810_1140148.0DomainRWD


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Fusion Gene Sequence for RWDD1-CEP85L


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>78746_78746_1_RWDD1-CEP85L_RWDD1_chr6_116906020_ENST00000466444_CEP85L_chr6_118845083_ENST00000360290_length(transcript)=1158nt_BP=486nt
AGAACGAGTCGAACGTGGAAGTAGGGAGCAGGCGGAGGCCGGCGCGGAGCTGCAGTTAAGCAAGCCGGGTCTGGCTTTGGGCCCTGGGCC
TTCCAGCCGGGGACTCTGCGCCTGCGCCCGCCTGGCCGCCGCCCGCTCTCCCGGCGCGGCAGCTGTCTGGGCTGCTGCGCGCCGCCTAGG
TGTCTGGGCGATCTATGGGCAAGAGCAAGGGCCACGATGACAGATTACGGCGAGGAGCAGCGCAACGAGCTGGAGGCCCTGGAGTCCATC
TACCCTGACTCCTTCACAGTATTATCAGAAAATCCACCCAGCTTCACCATTACTGTGACGTCTGAGGCTGGAGAAAATGATGAAACTGTC
CAGACTACCCTCAAGTTTACATACAGTGAAAAATACCCAGATGAAGCTCCCCTTTATGAAATATTCTCCCAGGAAAATCTAGAAGATAAT
GATGTCTCAGACATTTTAAAATTACTAGCATTACAGGTTTTGACTGGATCATCTCGTCAAAGTTATTCACCTGGCTATCAGGATTTCAGT
AAGTGGGAATCAATGTTGAAAATAAAAGAAGGACTTCTAAGGCAGAAAGAAATTGTAATCGATCGGCAGAAGCAACAAATTACCCACCTG
CATGAGAGGATAAGGGATAATGAATTACGGGCTCAACATGCCATGTTAGGACATTATGTAAATTGTGAGGATTCTTATGTGGCTAGTTTG
CAGCCACAATATGAGAACACTTCACTCCAGACACCATTTTCAGAGGAATCAGTTTCCCATTCCCAACAAGGGGAATTTGAGCAAAAGCTT
GCATCTACTGAGAAAGAAGTTTTACAGCTTAATGAGTTTCTCAAACAAAGACTAAGCCTATTTAGTGAAGAGAAGAAGAAACTAGAGGAA
AAAGTAGGTTTTTCTAATAAAGTTGAATTAGGTCAACAACATTTCCTCAGCATATAATTATTTGTCTGTCATTTACCCTGTCAGGTGTCA
TGCCAGGTTATGTATACATTTATGTGGAGGTGATTAATTTTGTAGTAACTTTTGAGAAGCCCTCTGCTGTCTGCAGAAATCCAAGGATTT

>78746_78746_1_RWDD1-CEP85L_RWDD1_chr6_116906020_ENST00000466444_CEP85L_chr6_118845083_ENST00000360290_length(amino acids)=283AA_BP=125
MRLRPPGRRPLSRRGSCLGCCAPPRCLGDLWARARATMTDYGEEQRNELEALESIYPDSFTVLSENPPSFTITVTSEAGENDETVQTTLK
FTYSEKYPDEAPLYEIFSQENLEDNDVSDILKLLALQVLTGSSRQSYSPGYQDFSKWESMLKIKEGLLRQKEIVIDRQKQQITHLHERIR
DNELRAQHAMLGHYVNCEDSYVASLQPQYENTSLQTPFSEESVSHSQQGEFEQKLASTEKEVLQLNEFLKQRLSLFSEEKKKLEEKVGFS

--------------------------------------------------------------
>78746_78746_2_RWDD1-CEP85L_RWDD1_chr6_116906020_ENST00000466444_CEP85L_chr6_118845083_ENST00000368488_length(transcript)=6508nt_BP=486nt
AGAACGAGTCGAACGTGGAAGTAGGGAGCAGGCGGAGGCCGGCGCGGAGCTGCAGTTAAGCAAGCCGGGTCTGGCTTTGGGCCCTGGGCC
TTCCAGCCGGGGACTCTGCGCCTGCGCCCGCCTGGCCGCCGCCCGCTCTCCCGGCGCGGCAGCTGTCTGGGCTGCTGCGCGCCGCCTAGG
TGTCTGGGCGATCTATGGGCAAGAGCAAGGGCCACGATGACAGATTACGGCGAGGAGCAGCGCAACGAGCTGGAGGCCCTGGAGTCCATC
TACCCTGACTCCTTCACAGTATTATCAGAAAATCCACCCAGCTTCACCATTACTGTGACGTCTGAGGCTGGAGAAAATGATGAAACTGTC
CAGACTACCCTCAAGTTTACATACAGTGAAAAATACCCAGATGAAGCTCCCCTTTATGAAATATTCTCCCAGGAAAATCTAGAAGATAAT
GATGTCTCAGACATTTTAAAATTACTAGCATTACAGGTTTTGACTGGATCATCTCGTCAAAGTTATTCACCTGGCTATCAGGATTTCAGT
AAGTGGGAATCAATGTTGAAAATAAAAGAAGGACTTCTAAGGCAGAAAGAAATTGTAATCGATCGGCAGAAGCAACAAATTACCCACCTG
CATGAGAGGATAAGGGATAATGAATTACGGGCTCAACATGCCATGTTAGGACATTATGTAAATTGTGAGGATTCTTATGTGGCTAGTTTG
CAGCCACAATATGAGAACACTTCACTCCAGACACCATTTTCAGAGGAATCAGTTTCCCATTCCCAACAAGGGGAATTTGAGCAAAAGCTT
GCATCTACTGAGAAAGAAGTTTTACAGCTTAATGAGTTTCTCAAACAAAGACTAAGCCTATTTAGTGAAGAGAAGAAGAAACTAGAGGAA
AAACTTAAAACTAGAGATCGATACATCAGTAGTCTGAAAAAGAAATGCCAGAAGGAATCTGAACAAAACAAAGAAAAGCAGAGAAGAATT
GAGACCTTGGAAAAGTATCTGGCTGATCTTCCAACTCTAGATGATGTACAGAGTCAGAGTCTACAGCTGCAGATTCTGGAAGAAAAAAAT
AAGAATTTACAAGAGGCTTTGATAGATACAGAAAAAAAACTTGAAGAGATCAAAAAGCAGTGTCAAGATAAAGAGACACAGTTAATATGC
CAGAAAAAGAAAGAAAAGGAGTTAGTAACTACCGTTCAGAGTTTGCAACAAAAAGTAGAAAGATGCCTTGAAGATGGAATCCGCCTTCCC
ATGTTAGATGCAAAACAGCTTCAGAATGAAAATGATAATCTCAGACAACAAAATGAGACTGCTAGTAAGATAATAGACAGCCAACAAGAT
GAGATTGACAGAATGATTTTAGAAATTCAGTCTATGCAAGGAAAGCTTTCTAAAGAGAAACTGACCACTCAAAAGATGATGGAAGAGCTG
GAAAAGAAAGAAAGAAATGTACAGAGATTAACAAAAGCATTGCTTGAAAACCAAAGACAAACAGATGAGACATGCTCTTTATTGGATCAG
GGCCAGGAACCTGACCAATCTAGGCAGCAGACAGTTCTTTCCAAACGGCCACTATTTGATTTGACTGTGATTGATCAGCTGTTCAAGGAA
ATGTCCTGTTGTTTGTTTGACTTGAAAGCATTGTGTAGTATTCTTAATCAGCGTGCTCAGGGCAAGGAGCCTAATCTTTCATTATTACTG
GGAATAAGATCAATGAACTGTTCAGCTGAAGAGACTGAGAATGACCACAGCACAGAAACACTCACTAAAAAGCTGTCAGATGTGTGCCAG
TTACGAAGAGACATTGATGAATTAAGGACTACAATATCAGACCGCTATGCTCAGGACATGGGAGACAACTGCATTACTCAGTGATCAAGT
GTTAGTCCCACAGCAATAATGACCTGTTGTTTAAATGCTGCTGTGTTATGGAGCCATAATGGAAGGTTGCAAGTGACATGACTTGCACTT
AGGGATTTTTTTTCTGTGGATTTGTTTTGTTGAAGGGGAGAAGGGAAGTGAAGAGATTTTGAAGGGGCTTATCTAATCAGGCAAAAAGAA
AAAAAATCAAATTACCTTTGGAAAATATGATAAAATCTACAAGGAAAAAAATGTCTATATTCTCAAACTACTGATTGTAGGACCAAGCTG
TGAAGAGTACCCTTCACATGAAGGAGTAGGATTCCTTTTAATCCTATAGCTTTGTGTGTTTGTGTGTGCATGTATGTGTGTTGTTGTGTG
TGTGTGCACGTGCTTTATTCACAAATTTATAAGGGTTTCTAGGGTCAGAGCAGAGCTTCTGAGAAAGGCACACGCTGTTTATTCTTATAT
TTCTTTCATATAGAAGCTTGTGTTGTACTTTGGGATTTTCAGTGGCTGGCTGAACAAGAGTTCAAACAGCAGGCAAGTGTTGTCATGGTA
GTACAGGAGGCAAAACCATTTATATTTTGAACACTTACTGCACTGATAGGATGTTTGTGGTTGAGCTGATTTTAGTACTGTAGATAGGTC
AGCTGTTTTTCCAGAGTGATTGTGGATTTCCCAAGAGGTGTGAAATTTTGACGTGATGCTCTTTTTCCTTAGCATTGTAATGTATGTGTT
ACAAGAAAGGTTAACATAACTTGAACTAATTTTAACATGTTCCTTACTATTTACAATTTTTTATTTATATGTTTTATATATATACATATA
TAAATGTAAACAAAGCCATATATAATTAATAAAGGCATTGGATCATTATTATAAAAGGAAGATTAACAAAGTTACCCTGGAACAATAGCT
TACTTATCCAAATCTCAACATTTACATTTTAACAGTTTTGTATGTTTCAAAGTTGAAACTACTGTAAGAGAAAGCCAATACTATTTATAT
CTGAATCAACAGTAGCATAAACATTTTTTAATTGAGATTGTATTTTAATCCCTTTTGTTAAAGTACATTAACAACAGTTTTTCACAGGAT
ATGAACTTGGCGAAATTAGTTCTTAATCTGAATTACAGGGTATTACTATGAAATGCAGTTGATTTTGCAGTAGACGTACAGTCATTTAAA
CTTCCAAATGAGTGTTGTCCATGTTTCTGTTGGTATTTTGGAAGGATTATACATTTTATTGCCTTCAGCATTGATTATGTTCTTTTGAAT
ATACTTAGTTTTGGCGAAAGCCTTGTCCTTTGTAAGTTGGTTTGATCTTGTGATGCAACCAAGTCTCATTTAGGTCAAGACTAAATAAGA
GATGGAGGGGTAGAGGGTGTGACTCAAGCAGGATAATATTGATTTGATAAAGAGCATATCACATGCCTGTTTTCTTGCCAGATAAAGGGC
ATAGCACATGCCTGTTTTCTTATATACTAGAATAAAGGCTCTCCTAGGAAAGATTTTTCTTAAATATTTAAAAGTGAAAATGTGAGACAA
GGCCTTCAAGGAGACTACCCAGGAAGATACACAGTTTAAAATGTTGGCTATACAGCTCTCAATAGATTATTTTATAGTTATAGTTGAATA
ATCAGTTATAATACACTGTAAAGAAATCAGATTTTCCTTCTGTTTGGTGTCTGAGTCCTTCCTGCTCTTCTTACTTCTGAGAATCTGGGC
ACTAAGAAATCAGTAAGTACATTGTAGTGCTCCTGCATCCCAGAGTCCTTAACCTAAGGAGGGTCTTAGTCACTGGTAAGAACTTGGCTT
TCTAATTATATTCACTTGGTTTTTAACATTAGTAGCTTGACGATAATCAGGGTATAGTAAATTTCCACCAAAAATGTGATGCGAAGAATT
CTGCCTTGGTCCTTTATGGTAAAACAGATAATAACGTCTAAAATAGATCAGCCACAAGTGCAGCAAATATTTTTACACTCTCTTTGAATA
GAATCCCAACCACCCTCCCCCATGATTTTAGAAATAAAGGCTTCCTAAAATAATAGAACAAATTGGCAAACAATCACTAATTGGACCAGT
AGGTTCTTACTTAAATATCTCTCCTAGATTTTTAGTGTATGTTTTGGGATTTTATGGGTTTATTTATTTTTTTTTTTTTAAGCAGACGTT
ACAGTTTGTTTTAATCTACTATAGATACGTTTTTGTTTTTTGGCTTAGTTGGGGATAAAATAATTTATTTGTAAGTTAGCTTTCTAAAAC
TTAGAGAAAGTAATTTAATTCACGTATCTTAAAAATAAAATTCCAAAGTTAAAAAATTTCTGACTTAGTAGGAAGTTAACAAAACTACTG
CTGATGCATTTCAGTTTCCAAAATCTGTACCCTCCCCCCATAAAAAAGGGAGTTAAGATGTGCTAGTTTAAGTAGTTAGCTGAATTATAG
ATTGATCCTCTTAAAATCTGGAGTTTGTAAAGGGGCCTACATAAACAGTAGATAGACTTGGAGGGATTTTGTGGGGGAATTGAAACTAAT
AGTATTCTATCTAGTTTGTCAGTATTTACTTTTTGATTTTTATTTTTCAGAAAATTTTCCTTTCCCAGGACACCCTCTTGTATTAGAATA
TCCTCTTCTGTATCACATTAAAAACAGATTTTACTGTTAGACCAAATAAGATGGGCAAATAGCAACACTAGAGCATCTCACCCAGTTTGA
ACTAGGATGTTCGTGGAAGTTATGACACCAATATATTCCTGAAATGAAAATTAACCTAAATTTTAAAGTGAATCTATTTGAAAATTTACT
TAGATAATGAAACCTCGTTTTAATTGTGCTTTTTGTGAATCCAACACTTGTTTGCTTAGAAAGTATCTTATCCAGTATTAATATTTTGTT
CTTTTGGGTTTTAAAGTTGAGCTTATTCAGCCTCAATCACATTACAGCAAGCATAAAGTAACAGTTGACTCAATGAAAGACCCAAATTGC
CTGTACAGATAAAATTCACTGAATCAAAGGCACAATAGCTATCTTTTCACTTGAGCTCAGAAAAGTAAAATGGCTTAATTTGAACTATTA
ATTTTCAGTGGCCTCTAATTAAACAAAAACAAAAAACCACAAATACTGGCTAGGTAAGATATTCCTGAGGTCATTTTAAAAGAAGTGTGG
CACCTAGGATTCAATATTTAATGCTAACAGTATTATATTTTAGTGAAATTTATTTTGGTGGTGACAGTTTATTAAACCTAATTAGACTTC
TTTCAATAGCTTGTTGTAGAGACAATCTCAAGGGCTGGAAAGTGTTGCTAAAATGAATGTCATACATTTCTGATATACTAAGGAGCTTAT
AAAGTAATTCTTTCATAGTGCAAGAATTATTAATTTCTTAGAGGATGTTTTTAAAGGAGCTACTTAATTGGGAAAATGTTCTTTAAATAT
CAGTAATAGTTCATTAAGTAACATAGTAGCTAAGAACATGGACTATATTTTCACAGCATAGTTCAGCTTAGGCACACCTTTAGTTTGGAT
TATTGGCATTCTCTTACGTAGGAATTATATCATTGTAGATATGTAATTATGGTAATAAGCAATTTTCATAACCATGCTCACTCAGACTAT
ATCATTTGAAACTGCCATGTTTCCATTTTTGACAATTCATGTTCACAAAACAACAGGAACAATTTCCTATTTGGTATAAAGAGCAAAATT
TCCAACTTTGCCCCAAAATGCCATGGGTGGCATATTGCCATATGATTATATCATATATTTAATCATGTATGGGAAAGATTTTGGATTTTT
TTTCTTATTTAAAAAAGTGCTAAATATAAGAATATAGTTTTAAATCAGCAAGTCTAATAACACTATTGCAGCTGTACACAGAGAGAACCT
TTTGTGCCTTTTTGCCTGCAGTAAGCATTTATTTCTATTTTACATGAGTTCTAAGAATGTTGATGATTATTGCACCTTGTTCTTCTGTAT
ATAAACTTGATTAAGGAATTTTTTTTTTTAAAGCAAGGAGCCGTTTTTTGTTACTAGGTGGATACCTTAGTAAACATGAGGGGAATTATC
AGATAGATGTCTTTGGAGCCCAGCCTTCCCTGTGTAGTGAGCTGGAAACTCCTTTAGATTGTATTCATTGGTGTGTATGTATATGTACAT
ATATGTATAAATAGTTAAATACATAAACATAAAACTTAACATCGCATTGTTGTGATGACAAGAAGTAGTAAGGTGCTAGGTGGTTACATT
AAAAAGCACAGCACAGTGTATAATCAGTCACTATGACTGGTGGTTTTGTAAGCTGGGTTCAGTTTTTGAACCACCCAGAATACCTCATGT
GTAAATACAGTGTTCATGACTTAATTGAAATACAGTTATTGTTTAAAAAAAAAAAAAAAGAATGTGAAGCCACTGGTTGGCTTATGCCTT
CTGATCTATCATTCTTGCCTCTTTTTTTGTAAAGGGGTTTTCTTCTTGTTGTTCTGTTTTTTAATAGGGTTTACAGCTAGAATTTTGAAT
GCCAAAGTTCTATTTATTAAATTAAGAAAAAAGTTTTCAATGTTAATGGCTAGTATTTTTCCACTGGACTATTGTTTGTTGATGTTGGAA

>78746_78746_2_RWDD1-CEP85L_RWDD1_chr6_116906020_ENST00000466444_CEP85L_chr6_118845083_ENST00000368488_length(amino acids)=592AA_BP=125
MRLRPPGRRPLSRRGSCLGCCAPPRCLGDLWARARATMTDYGEEQRNELEALESIYPDSFTVLSENPPSFTITVTSEAGENDETVQTTLK
FTYSEKYPDEAPLYEIFSQENLEDNDVSDILKLLALQVLTGSSRQSYSPGYQDFSKWESMLKIKEGLLRQKEIVIDRQKQQITHLHERIR
DNELRAQHAMLGHYVNCEDSYVASLQPQYENTSLQTPFSEESVSHSQQGEFEQKLASTEKEVLQLNEFLKQRLSLFSEEKKKLEEKLKTR
DRYISSLKKKCQKESEQNKEKQRRIETLEKYLADLPTLDDVQSQSLQLQILEEKNKNLQEALIDTEKKLEEIKKQCQDKETQLICQKKKE
KELVTTVQSLQQKVERCLEDGIRLPMLDAKQLQNENDNLRQQNETASKIIDSQQDEIDRMILEIQSMQGKLSKEKLTTQKMMEELEKKER
NVQRLTKALLENQRQTDETCSLLDQGQEPDQSRQQTVLSKRPLFDLTVIDQLFKEMSCCLFDLKALCSILNQRAQGKEPNLSLLLGIRSM

--------------------------------------------------------------
>78746_78746_3_RWDD1-CEP85L_RWDD1_chr6_116906020_ENST00000466444_CEP85L_chr6_118845083_ENST00000368491_length(transcript)=6517nt_BP=486nt
AGAACGAGTCGAACGTGGAAGTAGGGAGCAGGCGGAGGCCGGCGCGGAGCTGCAGTTAAGCAAGCCGGGTCTGGCTTTGGGCCCTGGGCC
TTCCAGCCGGGGACTCTGCGCCTGCGCCCGCCTGGCCGCCGCCCGCTCTCCCGGCGCGGCAGCTGTCTGGGCTGCTGCGCGCCGCCTAGG
TGTCTGGGCGATCTATGGGCAAGAGCAAGGGCCACGATGACAGATTACGGCGAGGAGCAGCGCAACGAGCTGGAGGCCCTGGAGTCCATC
TACCCTGACTCCTTCACAGTATTATCAGAAAATCCACCCAGCTTCACCATTACTGTGACGTCTGAGGCTGGAGAAAATGATGAAACTGTC
CAGACTACCCTCAAGTTTACATACAGTGAAAAATACCCAGATGAAGCTCCCCTTTATGAAATATTCTCCCAGGAAAATCTAGAAGATAAT
GATGTCTCAGACATTTTAAAATTACTAGCATTACAGGTTTTGACTGGATCATCTCGTCAAAGTTATTCACCTGGCTATCAGGATTTCAGT
AAGTGGGAATCAATGTTGAAAATAAAAGAAGGACTTCTAAGGCAGAAAGAAATTGTAATCGATCGGCAGAAGCAACAAATTACCCACCTG
CATGAGAGGATAAGGGATAATGAATTACGGGCTCAACATGCCATGTTAGGACATTATGTAAATTGTGAGGATTCTTATGTGGCTAGTTTG
CAGCCACAATATGAGAACACTTCACTCCAGACACCATTTTCAGAGGAATCAGTTTCCCATTCCCAACAAGGGGAATTTGAGCAAAAGCTT
GCATCTACTGAGAAAGAAGTTTTACAGCTTAATGAGTTTCTCAAACAAAGACTAAGCCTATTTAGTGAAGAGAAGAAGAAACTAGAGGAA
AAACTTAAAACTAGAGATCGATACATCAGTAGTCTGAAAAAGAAATGCCAGAAGGAATCTGAACAAAACAAAGAAAAGCAGAGAAGAATT
GAGACCTTGGAAAAGTATCTGGCTGATCTTCCAACTCTAGATGATGTACAGAGTCAGAGTCTACAGCTGCAGATTCTGGAAGAAAAAAAT
AAGAATTTACAAGAGGCTTTGATAGATACAGAAAAAAAACTTGAAGAGATCAAAAAGCAGTGTCAAGATAAAGAGACACAGTTAATATGC
CAGAAAAAGAAAGAAAAGGAGTTAGTAACTACCGTTCAGAGTTTGCAACAAAAAGTAGAAAGATGCCTTGAAGATGGAATCCGCCTTCCC
ATGTTAGATGCAAAACAGCTTCAGAATGAAAATGATAATCTCAGACAACAAAATGAGACTGCTAGTAAGATAATAGACAGCCAACAAGAT
GAGATTGACAGAATGATTTTAGAAATTCAGTCTATGCAAGGAAAGCTTTCTAAAGAGAAACTGACCACTCAAAAGATGATGGAAGAGCTG
GAAAAGAAAGAAAGAAATGTACAGAGATTAACAAAAGCATTGCTTGAAAACCAAAGACAAACAGATGAGACATGCTCTTTATTGGATCAG
GGCCAGGAACCTGACCAATCTAGGCAGCAGACAGTTCTTTCCAAACGGCCACTATTTGATTTGACTGTGATTGATCAGCTGTTCAAGGAA
ATGTCCTGTTGTTTGTTTGACTTGAAAGCATTGTGTAGTATTCTTAATCAGCGTGCTCAGGGCAAGGAGCCTAATCTTTCATTATTACTG
GGAATAAGATCAATGAACTGTTCAGCTGAAGAGACTGAGAATGACCACAGCACAGAAACACTCACTAAAAAGCTGTCAGATGTGTGCCAG
TTACGAAGAGACATTGATGAATTAAGGACTACAATATCAGACCGCTATGCTCAGGACATGGGAGACAACTGCATTACTCAGTGATCAAGT
GTTAGTCCCACAGCAATAATGACCTGTTGTTTAAATGCTGCTGTGTTATGGAGCCATAATGGAAGGTTGCAAGTGACATGACTTGCACTT
AGGGATTTTTTTTCTGTGGATTTGTTTTGTTGAAGGGGAGAAGGGAAGTGAAGAGATTTTGAAGGGGCTTATCTAATCAGGCAAAAAGAA
AAAAAATCAAATTACCTTTGGAAAATATGATAAAATCTACAAGGAAAAAAATGTCTATATTCTCAAACTACTGATTGTAGGACCAAGCTG
TGAAGAGTACCCTTCACATGAAGGAGTAGGATTCCTTTTAATCCTATAGCTTTGTGTGTTTGTGTGTGCATGTATGTGTGTTGTTGTGTG
TGTGTGCACGTGCTTTATTCACAAATTTATAAGGGTTTCTAGGGTCAGAGCAGAGCTTCTGAGAAAGGCACACGCTGTTTATTCTTATAT
TTCTTTCATATAGAAGCTTGTGTTGTACTTTGGGATTTTCAGTGGCTGGCTGAACAAGAGTTCAAACAGCAGGCAAGTGTTGTCATGGTA
GTACAGGAGGCAAAACCATTTATATTTTGAACACTTACTGCACTGATAGGATGTTTGTGGTTGAGCTGATTTTAGTACTGTAGATAGGTC
AGCTGTTTTTCCAGAGTGATTGTGGATTTCCCAAGAGGTGTGAAATTTTGACGTGATGCTCTTTTTCCTTAGCATTGTAATGTATGTGTT
ACAAGAAAGGTTAACATAACTTGAACTAATTTTAACATGTTCCTTACTATTTACAATTTTTTATTTATATGTTTTATATATATACATATA
TAAATGTAAACAAAGCCATATATAATTAATAAAGGCATTGGATCATTATTATAAAAGGAAGATTAACAAAGTTACCCTGGAACAATAGCT
TACTTATCCAAATCTCAACATTTACATTTTAACAGTTTTGTATGTTTCAAAGTTGAAACTACTGTAAGAGAAAGCCAATACTATTTATAT
CTGAATCAACAGTAGCATAAACATTTTTTAATTGAGATTGTATTTTAATCCCTTTTGTTAAAGTACATTAACAACAGTTTTTCACAGGAT
ATGAACTTGGCGAAATTAGTTCTTAATCTGAATTACAGGGTATTACTATGAAATGCAGTTGATTTTGCAGTAGACGTACAGTCATTTAAA
CTTCCAAATGAGTGTTGTCCATGTTTCTGTTGGTATTTTGGAAGGATTATACATTTTATTGCCTTCAGCATTGATTATGTTCTTTTGAAT
ATACTTAGTTTTGGCGAAAGCCTTGTCCTTTGTAAGTTGGTTTGATCTTGTGATGCAACCAAGTCTCATTTAGGTCAAGACTAAATAAGA
GATGGAGGGGTAGAGGGTGTGACTCAAGCAGGATAATATTGATTTGATAAAGAGCATATCACATGCCTGTTTTCTTGCCAGATAAAGGGC
ATAGCACATGCCTGTTTTCTTATATACTAGAATAAAGGCTCTCCTAGGAAAGATTTTTCTTAAATATTTAAAAGTGAAAATGTGAGACAA
GGCCTTCAAGGAGACTACCCAGGAAGATACACAGTTTAAAATGTTGGCTATACAGCTCTCAATAGATTATTTTATAGTTATAGTTGAATA
ATCAGTTATAATACACTGTAAAGAAATCAGATTTTCCTTCTGTTTGGTGTCTGAGTCCTTCCTGCTCTTCTTACTTCTGAGAATCTGGGC
ACTAAGAAATCAGTAAGTACATTGTAGTGCTCCTGCATCCCAGAGTCCTTAACCTAAGGAGGGTCTTAGTCACTGGTAAGAACTTGGCTT
TCTAATTATATTCACTTGGTTTTTAACATTAGTAGCTTGACGATAATCAGGGTATAGTAAATTTCCACCAAAAATGTGATGCGAAGAATT
CTGCCTTGGTCCTTTATGGTAAAACAGATAATAACGTCTAAAATAGATCAGCCACAAGTGCAGCAAATATTTTTACACTCTCTTTGAATA
GAATCCCAACCACCCTCCCCCATGATTTTAGAAATAAAGGCTTCCTAAAATAATAGAACAAATTGGCAAACAATCACTAATTGGACCAGT
AGGTTCTTACTTAAATATCTCTCCTAGATTTTTAGTGTATGTTTTGGGATTTTATGGGTTTATTTATTTTTTTTTTTTTAAGCAGACGTT
ACAGTTTGTTTTAATCTACTATAGATACGTTTTTGTTTTTTGGCTTAGTTGGGGATAAAATAATTTATTTGTAAGTTAGCTTTCTAAAAC
TTAGAGAAAGTAATTTAATTCACGTATCTTAAAAATAAAATTCCAAAGTTAAAAAATTTCTGACTTAGTAGGAAGTTAACAAAACTACTG
CTGATGCATTTCAGTTTCCAAAATCTGTACCCTCCCCCCATAAAAAAGGGAGTTAAGATGTGCTAGTTTAAGTAGTTAGCTGAATTATAG
ATTGATCCTCTTAAAATCTGGAGTTTGTAAAGGGGCCTACATAAACAGTAGATAGACTTGGAGGGATTTTGTGGGGGAATTGAAACTAAT
AGTATTCTATCTAGTTTGTCAGTATTTACTTTTTGATTTTTATTTTTCAGAAAATTTTCCTTTCCCAGGACACCCTCTTGTATTAGAATA
TCCTCTTCTGTATCACATTAAAAACAGATTTTACTGTTAGACCAAATAAGATGGGCAAATAGCAACACTAGAGCATCTCACCCAGTTTGA
ACTAGGATGTTCGTGGAAGTTATGACACCAATATATTCCTGAAATGAAAATTAACCTAAATTTTAAAGTGAATCTATTTGAAAATTTACT
TAGATAATGAAACCTCGTTTTAATTGTGCTTTTTGTGAATCCAACACTTGTTTGCTTAGAAAGTATCTTATCCAGTATTAATATTTTGTT
CTTTTGGGTTTTAAAGTTGAGCTTATTCAGCCTCAATCACATTACAGCAAGCATAAAGTAACAGTTGACTCAATGAAAGACCCAAATTGC
CTGTACAGATAAAATTCACTGAATCAAAGGCACAATAGCTATCTTTTCACTTGAGCTCAGAAAAGTAAAATGGCTTAATTTGAACTATTA
ATTTTCAGTGGCCTCTAATTAAACAAAAACAAAAAACCACAAATACTGGCTAGGTAAGATATTCCTGAGGTCATTTTAAAAGAAGTGTGG
CACCTAGGATTCAATATTTAATGCTAACAGTATTATATTTTAGTGAAATTTATTTTGGTGGTGACAGTTTATTAAACCTAATTAGACTTC
TTTCAATAGCTTGTTGTAGAGACAATCTCAAGGGCTGGAAAGTGTTGCTAAAATGAATGTCATACATTTCTGATATACTAAGGAGCTTAT
AAAGTAATTCTTTCATAGTGCAAGAATTATTAATTTCTTAGAGGATGTTTTTAAAGGAGCTACTTAATTGGGAAAATGTTCTTTAAATAT
CAGTAATAGTTCATTAAGTAACATAGTAGCTAAGAACATGGACTATATTTTCACAGCATAGTTCAGCTTAGGCACACCTTTAGTTTGGAT
TATTGGCATTCTCTTACGTAGGAATTATATCATTGTAGATATGTAATTATGGTAATAAGCAATTTTCATAACCATGCTCACTCAGACTAT
ATCATTTGAAACTGCCATGTTTCCATTTTTGACAATTCATGTTCACAAAACAACAGGAACAATTTCCTATTTGGTATAAAGAGCAAAATT
TCCAACTTTGCCCCAAAATGCCATGGGTGGCATATTGCCATATGATTATATCATATATTTAATCATGTATGGGAAAGATTTTGGATTTTT
TTTCTTATTTAAAAAAGTGCTAAATATAAGAATATAGTTTTAAATCAGCAAGTCTAATAACACTATTGCAGCTGTACACAGAGAGAACCT
TTTGTGCCTTTTTGCCTGCAGTAAGCATTTATTTCTATTTTACATGAGTTCTAAGAATGTTGATGATTATTGCACCTTGTTCTTCTGTAT
ATAAACTTGATTAAGGAATTTTTTTTTTTAAAGCAAGGAGCCGTTTTTTGTTACTAGGTGGATACCTTAGTAAACATGAGGGGAATTATC
AGATAGATGTCTTTGGAGCCCAGCCTTCCCTGTGTAGTGAGCTGGAAACTCCTTTAGATTGTATTCATTGGTGTGTATGTATATGTACAT
ATATGTATAAATAGTTAAATACATAAACATAAAACTTAACATCGCATTGTTGTGATGACAAGAAGTAGTAAGGTGCTAGGTGGTTACATT
AAAAAGCACAGCACAGTGTATAATCAGTCACTATGACTGGTGGTTTTGTAAGCTGGGTTCAGTTTTTGAACCACCCAGAATACCTCATGT
GTAAATACAGTGTTCATGACTTAATTGAAATACAGTTATTGTTTAAAAAAAAAAAAAAAGAATGTGAAGCCACTGGTTGGCTTATGCCTT
CTGATCTATCATTCTTGCCTCTTTTTTTGTAAAGGGGTTTTCTTCTTGTTGTTCTGTTTTTTAATAGGGTTTACAGCTAGAATTTTGAAT
GCCAAAGTTCTATTTATTAAATTAAGAAAAAAGTTTTCAATGTTAATGGCTAGTATTTTTCCACTGGACTATTGTTTGTTGATGTTGGAA

>78746_78746_3_RWDD1-CEP85L_RWDD1_chr6_116906020_ENST00000466444_CEP85L_chr6_118845083_ENST00000368491_length(amino acids)=592AA_BP=125
MRLRPPGRRPLSRRGSCLGCCAPPRCLGDLWARARATMTDYGEEQRNELEALESIYPDSFTVLSENPPSFTITVTSEAGENDETVQTTLK
FTYSEKYPDEAPLYEIFSQENLEDNDVSDILKLLALQVLTGSSRQSYSPGYQDFSKWESMLKIKEGLLRQKEIVIDRQKQQITHLHERIR
DNELRAQHAMLGHYVNCEDSYVASLQPQYENTSLQTPFSEESVSHSQQGEFEQKLASTEKEVLQLNEFLKQRLSLFSEEKKKLEEKLKTR
DRYISSLKKKCQKESEQNKEKQRRIETLEKYLADLPTLDDVQSQSLQLQILEEKNKNLQEALIDTEKKLEEIKKQCQDKETQLICQKKKE
KELVTTVQSLQQKVERCLEDGIRLPMLDAKQLQNENDNLRQQNETASKIIDSQQDEIDRMILEIQSMQGKLSKEKLTTQKMMEELEKKER
NVQRLTKALLENQRQTDETCSLLDQGQEPDQSRQQTVLSKRPLFDLTVIDQLFKEMSCCLFDLKALCSILNQRAQGKEPNLSLLLGIRSM

--------------------------------------------------------------
>78746_78746_4_RWDD1-CEP85L_RWDD1_chr6_116906020_ENST00000466444_CEP85L_chr6_118845083_ENST00000392500_length(transcript)=1158nt_BP=486nt
AGAACGAGTCGAACGTGGAAGTAGGGAGCAGGCGGAGGCCGGCGCGGAGCTGCAGTTAAGCAAGCCGGGTCTGGCTTTGGGCCCTGGGCC
TTCCAGCCGGGGACTCTGCGCCTGCGCCCGCCTGGCCGCCGCCCGCTCTCCCGGCGCGGCAGCTGTCTGGGCTGCTGCGCGCCGCCTAGG
TGTCTGGGCGATCTATGGGCAAGAGCAAGGGCCACGATGACAGATTACGGCGAGGAGCAGCGCAACGAGCTGGAGGCCCTGGAGTCCATC
TACCCTGACTCCTTCACAGTATTATCAGAAAATCCACCCAGCTTCACCATTACTGTGACGTCTGAGGCTGGAGAAAATGATGAAACTGTC
CAGACTACCCTCAAGTTTACATACAGTGAAAAATACCCAGATGAAGCTCCCCTTTATGAAATATTCTCCCAGGAAAATCTAGAAGATAAT
GATGTCTCAGACATTTTAAAATTACTAGCATTACAGGTTTTGACTGGATCATCTCGTCAAAGTTATTCACCTGGCTATCAGGATTTCAGT
AAGTGGGAATCAATGTTGAAAATAAAAGAAGGACTTCTAAGGCAGAAAGAAATTGTAATCGATCGGCAGAAGCAACAAATTACCCACCTG
CATGAGAGGATAAGGGATAATGAATTACGGGCTCAACATGCCATGTTAGGACATTATGTAAATTGTGAGGATTCTTATGTGGCTAGTTTG
CAGCCACAATATGAGAACACTTCACTCCAGACACCATTTTCAGAGGAATCAGTTTCCCATTCCCAACAAGGGGAATTTGAGCAAAAGCTT
GCATCTACTGAGAAAGAAGTTTTACAGCTTAATGAGTTTCTCAAACAAAGACTAAGCCTATTTAGTGAAGAGAAGAAGAAACTAGAGGAA
AAAGTAGGTTTTTCTAATAAAGTTGAATTAGGTCAACAACATTTCCTCAGCATATAATTATTTGTCTGTCATTTACCCTGTCAGGTGTCA
TGCCAGGTTATGTATACATTTATGTGGAGGTGATTAATTTTGTAGTAACTTTTGAGAAGCCCTCTGCTGTCTGCAGAAATCCAAGGATTT

>78746_78746_4_RWDD1-CEP85L_RWDD1_chr6_116906020_ENST00000466444_CEP85L_chr6_118845083_ENST00000392500_length(amino acids)=283AA_BP=125
MRLRPPGRRPLSRRGSCLGCCAPPRCLGDLWARARATMTDYGEEQRNELEALESIYPDSFTVLSENPPSFTITVTSEAGENDETVQTTLK
FTYSEKYPDEAPLYEIFSQENLEDNDVSDILKLLALQVLTGSSRQSYSPGYQDFSKWESMLKIKEGLLRQKEIVIDRQKQQITHLHERIR
DNELRAQHAMLGHYVNCEDSYVASLQPQYENTSLQTPFSEESVSHSQQGEFEQKLASTEKEVLQLNEFLKQRLSLFSEEKKKLEEKVGFS

--------------------------------------------------------------
>78746_78746_5_RWDD1-CEP85L_RWDD1_chr6_116906020_ENST00000466444_CEP85L_chr6_118845083_ENST00000419517_length(transcript)=957nt_BP=486nt
AGAACGAGTCGAACGTGGAAGTAGGGAGCAGGCGGAGGCCGGCGCGGAGCTGCAGTTAAGCAAGCCGGGTCTGGCTTTGGGCCCTGGGCC
TTCCAGCCGGGGACTCTGCGCCTGCGCCCGCCTGGCCGCCGCCCGCTCTCCCGGCGCGGCAGCTGTCTGGGCTGCTGCGCGCCGCCTAGG
TGTCTGGGCGATCTATGGGCAAGAGCAAGGGCCACGATGACAGATTACGGCGAGGAGCAGCGCAACGAGCTGGAGGCCCTGGAGTCCATC
TACCCTGACTCCTTCACAGTATTATCAGAAAATCCACCCAGCTTCACCATTACTGTGACGTCTGAGGCTGGAGAAAATGATGAAACTGTC
CAGACTACCCTCAAGTTTACATACAGTGAAAAATACCCAGATGAAGCTCCCCTTTATGAAATATTCTCCCAGGAAAATCTAGAAGATAAT
GATGTCTCAGACATTTTAAAATTACTAGCATTACAGGTTTTGACTGGATCATCTCGTCAAAGTTATTCACCTGGCTATCAGGATTTCAGT
AAGTGGGAATCAATGTTGAAAATAAAAGAAGGACTTCTAAGGCAGAAAGAAATTGTAATCGATCGGCAGAAGCAACAAATTACCCACCTG
CATGAGAGGATAAGGGATAATGAATTACGGGCTCAACATGCCATGTTAGGACATTATGTAAATTGTGAGGATTCTTATGTGGCTAGTTTG
CAGCCACAATATGAGAACACTTCACTCCAGACACCATTTTCAGAGGAATCAGTTTCCCATTCCCAACAAGGGGAATTTGAGCAAAAGCTT
GCATCTACTGAGAAAGAAGTTTTACAGCTTAATGAGTTTCTCAAACAAAGACTAAGCCTATTTAGTGAAGAGAAGAAGAAACTAGAGGAA

>78746_78746_5_RWDD1-CEP85L_RWDD1_chr6_116906020_ENST00000466444_CEP85L_chr6_118845083_ENST00000419517_length(amino acids)=283AA_BP=125
MRLRPPGRRPLSRRGSCLGCCAPPRCLGDLWARARATMTDYGEEQRNELEALESIYPDSFTVLSENPPSFTITVTSEAGENDETVQTTLK
FTYSEKYPDEAPLYEIFSQENLEDNDVSDILKLLALQVLTGSSRQSYSPGYQDFSKWESMLKIKEGLLRQKEIVIDRQKQQITHLHERIR
DNELRAQHAMLGHYVNCEDSYVASLQPQYENTSLQTPFSEESVSHSQQGEFEQKLASTEKEVLQLNEFLKQRLSLFSEEKKKLEEKVGFS

--------------------------------------------------------------

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Fusion Gene PPI Analysis for RWDD1-CEP85L


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneRWDD1chr6:116906020chr6:118845083ENST00000392526+59142_1970148.0DRG2
HgeneRWDD1chr6:116906020chr6:118845083ENST00000466444+37142_19790.0244.0DRG2
HgeneRWDD1chr6:116906020chr6:118845083ENST00000487832+48142_1970148.0DRG2


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for RWDD1-CEP85L


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for RWDD1-CEP85L


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource