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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:RYR2-MTR (FusionGDB2 ID:78806)

Fusion Gene Summary for RYR2-MTR

check button Fusion gene summary
Fusion gene informationFusion gene name: RYR2-MTR
Fusion gene ID: 78806
HgeneTgene
Gene symbol

RYR2

MTR

Gene ID

6262

4548

Gene nameryanodine receptor 25-methyltetrahydrofolate-homocysteine methyltransferase
SynonymsARVC2|ARVD2|RYR-2|RyR|VTSIPHMAG|MS|cblG
Cytomap

1q43

1q43

Type of geneprotein-codingprotein-coding
Descriptionryanodine receptor 2cardiac muscle ryanodine receptor-calcium release channelcardiac-type ryanodine receptorislet-type ryanodine receptorkidney-type ryanodine receptorryanodine receptor 2 (cardiac)type 2 ryanodine receptormethionine synthase5-methyltetrahydrofolate-homocysteine methyltransferase 1cobalamin-dependent methionine synthasevitamin-B12 dependent methionine synthase
Modification date2020031520200313
UniProtAcc.

Q9UBK8

Ensembl transtripts involved in fusion geneENST00000360064, ENST00000366574, 
ENST00000542537, ENST00000609119, 
ENST00000418145, ENST00000470570, 
ENST00000535889, ENST00000366577, 
Fusion gene scores* DoF score10 X 11 X 5=5505 X 5 X 2=50
# samples 115
** MAII scorelog2(11/550*10)=-2.32192809488736
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(5/50*10)=0
Context

PubMed: RYR2 [Title/Abstract] AND MTR [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointRYR2(237551483)-MTR(237044055), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneRYR2

GO:0005513

detection of calcium ion

10830164

HgeneRYR2

GO:0006816

calcium ion transport

17921453

HgeneRYR2

GO:0031000

response to caffeine

17921453

HgeneRYR2

GO:0035584

calcium-mediated signaling using intracellular calcium source

17921453

HgeneRYR2

GO:0051209

release of sequestered calcium ion into cytosol

12443530|17921453

HgeneRYR2

GO:0051284

positive regulation of sequestering of calcium ion

12443530|12919952

HgeneRYR2

GO:0051775

response to redox state

19226252

HgeneRYR2

GO:0060402

calcium ion transport into cytosol

17921453

HgeneRYR2

GO:0071313

cellular response to caffeine

12919952

HgeneRYR2

GO:0072599

establishment of protein localization to endoplasmic reticulum

12443530

HgeneRYR2

GO:1901896

positive regulation of calcium-transporting ATPase activity

12443530


check buttonFusion gene breakpoints across RYR2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across MTR (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4Non-CancerERR315413RYR2chr1

237551483

+MTRchr1

237044055

+


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Fusion Gene ORF analysis for RYR2-MTR

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000360064ENST00000418145RYR2chr1

237551483

+MTRchr1

237044055

+
5CDS-intronENST00000360064ENST00000470570RYR2chr1

237551483

+MTRchr1

237044055

+
5CDS-intronENST00000360064ENST00000535889RYR2chr1

237551483

+MTRchr1

237044055

+
5CDS-intronENST00000366574ENST00000418145RYR2chr1

237551483

+MTRchr1

237044055

+
5CDS-intronENST00000366574ENST00000470570RYR2chr1

237551483

+MTRchr1

237044055

+
5CDS-intronENST00000366574ENST00000535889RYR2chr1

237551483

+MTRchr1

237044055

+
5CDS-intronENST00000542537ENST00000418145RYR2chr1

237551483

+MTRchr1

237044055

+
5CDS-intronENST00000542537ENST00000470570RYR2chr1

237551483

+MTRchr1

237044055

+
5CDS-intronENST00000542537ENST00000535889RYR2chr1

237551483

+MTRchr1

237044055

+
In-frameENST00000360064ENST00000366577RYR2chr1

237551483

+MTRchr1

237044055

+
In-frameENST00000366574ENST00000366577RYR2chr1

237551483

+MTRchr1

237044055

+
In-frameENST00000542537ENST00000366577RYR2chr1

237551483

+MTRchr1

237044055

+
intron-3CDSENST00000609119ENST00000366577RYR2chr1

237551483

+MTRchr1

237044055

+
intron-intronENST00000609119ENST00000418145RYR2chr1

237551483

+MTRchr1

237044055

+
intron-intronENST00000609119ENST00000470570RYR2chr1

237551483

+MTRchr1

237044055

+
intron-intronENST00000609119ENST00000535889RYR2chr1

237551483

+MTRchr1

237044055

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000366574RYR2chr1237551483+ENST00000366577MTRchr1237044055+86311090352293752
ENST00000360064RYR2chr1237551483+ENST00000366577MTRchr1237044055+830876701970656
ENST00000542537RYR2chr1237551483+ENST00000366577MTRchr1237044055+8266725151928637

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000366574ENST00000366577RYR2chr1237551483+MTRchr1237044055+0.0005640660.99943596
ENST00000360064ENST00000366577RYR2chr1237551483+MTRchr1237044055+0.0013179210.9986821
ENST00000542537ENST00000366577RYR2chr1237551483+MTRchr1237044055+0.0005499840.99945

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Fusion Genomic Features for RYR2-MTR


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
RYR2chr1237551483+MTRchr1237044054+0.0001025480.9998975
RYR2chr1237551483+MTRchr1237044054+0.0001025480.9998975

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for RYR2-MTR


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:237551483/chr1:237044055)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.MTR

Q9UBK8

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Key enzyme in methionine and folate homeostasis responsible for the reactivation of methionine synthase (MTR/MS) activity by catalyzing the reductive methylation of MTR-bound cob(II)alamin (PubMed:17892308). Cobalamin (vitamin B12) forms a complex with MTR to serve as an intermediary in methyl transfer reactions that cycles between MTR-bound methylcob(III)alamin and MTR bound-cob(I)alamin forms, and occasional oxidative escape of the cob(I)alamin intermediate during the catalytic cycle leads to the inactive cob(II)alamin species (Probable). The processing of cobalamin in the cytosol occurs in a multiprotein complex composed of at least MMACHC, MMADHC, MTRR and MTR which may contribute to shuttle safely and efficiently cobalamin towards MTR in order to produce methionine (PubMed:27771510). Also necessary for the utilization of methyl groups from the folate cycle, thereby affecting transgenerational epigenetic inheritance (By similarity). Also acts as a molecular chaperone for methionine synthase by stabilizing apoMTR and incorporating methylcob(III)alamin into apoMTR to form the holoenzyme (PubMed:16769880). Also serves as an aquacob(III)alamin reductase by reducing aquacob(III)alamin to cob(II)alamin; this reduction leads to stimulation of the conversion of apoMTR and aquacob(III)alamin to MTR holoenzyme (PubMed:16769880). {ECO:0000250|UniProtKB:Q8C1A3, ECO:0000269|PubMed:16769880, ECO:0000269|PubMed:17892308, ECO:0000269|PubMed:27771510, ECO:0000305|PubMed:19243433}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneRYR2chr1:237551483chr1:237044055ENST00000366574+10105110_1652574968.0DomainMIR 1
HgeneRYR2chr1:237551483chr1:237044055ENST00000366574+10105172_2172574968.0DomainMIR 2
TgeneMTRchr1:237551483chr1:237044055ENST000003665772333923_12658641266.0DomainAdoMet activation
TgeneMTRchr1:237551483chr1:237044055ENST0000036657723331227_12288641266.0RegionS-adenosyl-L-methionine binding

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneRYR2chr1:237551483chr1:237044055ENST00000366574+101054412_44452574968.0Coiled coilOntology_term=ECO:0000255
HgeneRYR2chr1:237551483chr1:237044055ENST00000366574+101054414_44552574968.0Compositional biasNote=Glu-rich (acidic)
HgeneRYR2chr1:237551483chr1:237044055ENST00000366574+101051025_12222574968.0DomainB30.2/SPRY 2
HgeneRYR2chr1:237551483chr1:237044055ENST00000366574+101051337_15622574968.0DomainB30.2/SPRY 3
HgeneRYR2chr1:237551483chr1:237044055ENST00000366574+10105225_2802574968.0DomainMIR 3
HgeneRYR2chr1:237551483chr1:237044055ENST00000366574+10105286_3432574968.0DomainMIR 4
HgeneRYR2chr1:237551483chr1:237044055ENST00000366574+10105351_4082574968.0DomainMIR 5
HgeneRYR2chr1:237551483chr1:237044055ENST00000366574+10105599_8092574968.0DomainB30.2/SPRY 1
HgeneRYR2chr1:237551483chr1:237044055ENST00000366574+101054820_48292574968.0IntramembranePore-forming
HgeneRYR2chr1:237551483chr1:237044055ENST00000366574+10105853_29252574968.0RegionNote=4 X approximate repeats
HgeneRYR2chr1:237551483chr1:237044055ENST00000366574+101052692_28102574968.0RepeatNote=3
HgeneRYR2chr1:237551483chr1:237044055ENST00000366574+101052812_29252574968.0RepeatNote=4
HgeneRYR2chr1:237551483chr1:237044055ENST00000366574+10105853_9662574968.0RepeatNote=1
HgeneRYR2chr1:237551483chr1:237044055ENST00000366574+10105967_10802574968.0RepeatNote=2
HgeneRYR2chr1:237551483chr1:237044055ENST00000366574+101051_42812574968.0Topological domainCytoplasmic
HgeneRYR2chr1:237551483chr1:237044055ENST00000366574+101054871_49672574968.0Topological domainCytoplasmic
HgeneRYR2chr1:237551483chr1:237044055ENST00000366574+101054282_43022574968.0TransmembraneHelical
HgeneRYR2chr1:237551483chr1:237044055ENST00000366574+101054504_45242574968.0TransmembraneHelical
HgeneRYR2chr1:237551483chr1:237044055ENST00000366574+101054580_46002574968.0TransmembraneHelical
HgeneRYR2chr1:237551483chr1:237044055ENST00000366574+101054730_47502574968.0TransmembraneHelical
HgeneRYR2chr1:237551483chr1:237044055ENST00000366574+101054769_47892574968.0TransmembraneHelical
HgeneRYR2chr1:237551483chr1:237044055ENST00000366574+101054850_48702574968.0TransmembraneHelical
TgeneMTRchr1:237551483chr1:237044055ENST00000366577233319_3388641266.0DomainHcy-binding
TgeneMTRchr1:237551483chr1:237044055ENST000003665772333371_6328641266.0DomainPterin-binding
TgeneMTRchr1:237551483chr1:237044055ENST000003665772333662_7598641266.0DomainB12-binding N-terminal
TgeneMTRchr1:237551483chr1:237044055ENST000003665772333772_9078641266.0DomainB12-binding
TgeneMTRchr1:237551483chr1:237044055ENST000003665772333382_3848641266.0RegionSubstrate binding
TgeneMTRchr1:237551483chr1:237044055ENST000003665772333782_7868641266.0RegionMethylcob(III)alamin binding


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Fusion Gene Sequence for RYR2-MTR


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>78806_78806_1_RYR2-MTR_RYR2_chr1_237551483_ENST00000360064_MTR_chr1_237044055_ENST00000366577_length(transcript)=8308nt_BP=767nt
CTGGGCCCTAGATCCTCATCTAACAAGCTCTCAAATAAAAAGATGATGAAGTGGTTCTGCAGTGCACCGCAACCATCCACAAAGAACAAC
AGAAGCTATGCTTGGCAGCAGAAGGATTTGGCAACAGACTTTGTTTCTTGGAGTCCACTTCCAATTCCAAGAATGTGCCCCCAGACCTCT
CCATCTGCACCTTTGTGCTGGAGCAGTCCCTCTCTGTCCGGGCGCTGCAGGAGATGCTGGCTAACACCGTGGAGAAATCAGAAGGGGCAA
CTAGATATCATTAAATGGTCATTTGGTCTAAAGACTGCTCAAGGTGGTGGTCATCGAACACTCCTCTACGGACATGCCATATTGCTGCGC
CATTCCTATAGTGGCATGTATCTGTGCTGCCTGTCCACCTCCCGGTCTTCAACTGATAAGCTGGCTTTTGATGTTGGCTTGCAAGAGGAC
ACCACAGGGGAGGCTTGTTGGTGGACCATACACCCTGCCTCTAAGCAGCGATCAGAAGGAGAAAAAGTACGAGTTGGAGATGACCTCATC
TTAGTTAGCGTGTCCTCTGAAAGGTACTTGCACTTGTCTTATGGCAACGGCAGCTTACACGTGGATGCCGCTTTCCAGCAGACTCTCTGG
AGCGTGGCCCCAATCAGCTCAGGAAGTGAGGCAGCCCAAGGGTATCTCATTGGTGGTGATGTCCTCAGGTTGCTGCATGGACACATGGAC
GAGTGTCTCACTGTCCCTTCAGGAGAACATGGTGAAGAGCAGCGGAGAACCCACACAGCAGTTAAAATAGCTCCGAGATACAGTGCACCT
GTAATCCATGTCCTGGACGCGTCCAAGAGTGTGGTGGTGTGTTCCCAGCTGTTAGATGAAAATCTAAAGGATGAATACTTTGAGGAAATC
ATGGAAGAATATGAAGATATTAGACAGGACCATTATGAGTCTCTCAAGGAGAGGAGATACTTACCCTTAAGTCAAGCCAGAAAAAGTGGT
TTCCAAATGGATTGGCTGTCTGAACCTCACCCAGTGAAGCCCACGTTTATTGGGACCCAGGTCTTTGAAGACTATGACCTGCAGAAGCTG
GTGGACTACATTGACTGGAAGCCTTTCTTTGATGTCTGGCAGCTCCGGGGCAAGTACCCGAATCGAGGCTTTCCCAAGATATTTAACGAC
AAAACAGTAGGTGGAGAGGCCAGGAAGGTCTACGATGATGCCCACAATATGCTGAACACACTGATTAGTCAAAAGAAACTCCGGGCCCGG
GGTGTGGTTGGGTTCTGGCCAGCACAGAGTATCCAAGACGACATTCACCTGTACGCAGAGGCTGCTGTGCCCCAGGCTGCAGAGCCCATA
GCCACCTTCTATGGGTTAAGGCAACAGGCTGAGAAGGACTCTGCCAGCACGGAGCCATACTACTGCCTCTCAGACTTCATCGCTCCCTTG
CATTCTGGCATCCGTGACTACCTGGGCCTGTTTGCCGTTGCCTGCTTTGGGGTAGAAGAGCTGAGCAAGGCCTATGAGGATGATGGTGAC
GACTACAGCAGCATCATGGTCAAGGCGCTGGGGGACCGGCTGGCAGAGGCCTTTGCAGAAGAGCTCCATGAAAGAGTTCGCCGAGAACTG
TGGGCCTACTGTGGCAGTGAGCAGCTGGACGTCGCAGACCTGCGCAGGCTGCGGTACAAGGGCATCCGCCCGGCTCCTGGCTACCCCAGC
CAGCCCGACCACACCGAGAAGCTCACCATGTGGAGACTCGCAGACATCGAGCAGTCTACAGGCATTAGGTTAACAGAATCATTAGCAATG
GCACCTGCTTCAGCAGTCTCAGGCCTCTACTTCTCCAATTTGAAGTCCAAATATTTTGCTGTGGGGAAGATTTCCAAGGATCAGGTTGAG
GATTATGCATTGAGGAAGAACATATCTGTGGCTGAGGTTGAGAAATGGCTTGGACCCATTTTGGGATATGATACAGACTAACTTTTTTTT
TTTTTTTGCCTTTTTTATTCTTGATGATCCTCAAGGAAATACAACCTAGGGTGCCTTAAAAATAACAACAACAAAAAACCTGTGTGCATC
TGGCTGACACTTACCTGCTTCTGGTTTTCGAAGACTATTTAGTGGAACCTTGTAGAGGAGCAGGGTCTTCCTGCAGTGCCTGGAAAACAG
GCGCTGTTTTTTTGGGACCTTGCGTGAAGAGCAGTGAGCAGGGTTCCTGTGGTTTCCCTGGTCCCTCTGAGATGGGGACAGACTGAAGAC
AGAGGTCGTTTGATTTCAAAGCAAGTCAACCTGCTTTTTTCTGTTTTTACAGTGGAATCTAGGAGGCCACTTAGTCGTCTTTTTTTCCTC
TTAGAAGAAAAGCCTGAAACTGAGTTGAATAGAGAAGTGTGACCCTGTGACAAAATGATACTGTGAGAAATGGGGCATTTTAATCTAAGT
GGTTATAACAGTGGATTCTGACGGGGAAGGTGTAGCTCTGTTCTCTTCGGAAGACCTCGTTTTCTAAAGGCTGGACTAAATGGCTGCAGA
ACTCCCTTTGGCAAAAGGCATGCGCTCACTGCTTGCTTGTCAGAAACACTGAAGCCATTTGCCCCAGTGTGGTCAAGCAGCCATGCTTTC
TGGGCATTTTCGTCCTCCCATAATTTCATATTTCCGTACCCCTGAGGAAACAAAAAGGAAATGAGGAGAGAAAGTTACTGTTAAGGGTGG
TTAACATTTTTTTTGTTTTGTTTTGTTTTGGTTTTTTTTTTTTTGAGACAGAGTCTGGCTCTGTCGCCCAGGCTGGAGTGCAGGGGCGCA
ATCTCGGCTCATAGCAAGCTCCGCCTCCTGGGTTCATGCCATTCTCCTGCCTCAGCCTCCAGAGTAGCTGGGACTACAGGTGCCCGCCAC
CACACCCGGCTAATTTTTTGTGTTTTTACAAAATACAAAAAAGTAGAGACAGGATTTCACTGTGTTAGCCAGGATGGTCTTGATCTCCCG
ACCTCGTGATCTGCCCACCTCAGCCTCCCAAAATGCTGGGATTACAGGCGTGAGCCACCGAGCCTGGCCGGTTAACATCTTTTAATTGTT
TCCAGGATTGAGCAGGTTCTCAGCTGGGCTCTGATATCCCGTGCGGAGTTGGACAAGTGGGCAGCATAAAGTCACTCATTTCTTACCATT
TTATTCCCCTCAATTCTCAATATATTCAGTAATGAAGAATGGTGCCACCACTCAAGCAACAAGCCTCAAACTCAACCATGTCATCTTTTT
CTTGGATGATTGCAGTTATTTCAAAAATTTGCATGCAAAATATACACTCATCCTACTTCAAGATGGTGGTGGCAATAGTCAGGAGAAGGT
AACATTGGAGTCCTGGTTTGATTCGAAGGATGAAGACGAAGAAGCAAGGGAGGAACAAATGAAGAACCATCTTTGTTCATGAATAGGAAT
ATTCAAGATTATAAAGGTATCAGGTCTCCTAAAATTGATCTATGGATTTAATACCATTTTCAATGGAAATTCCAACAGATTTTATTGAAT
GAAACAAGCAGGTGTTTATATGGAGTAGCAAAGGACTTAAAATTACCAAATGCTTCTAAATATGAAGGAGAGGTTGGGGACACGCACCCT
ATGTGATACCAAGTTTTATTGTCAAGACAGTGTCATGGTGCAGAGGTAGGCATTCTGAGCAGGGGAACAAAATAAGGGCCTAGAAACTCA
CCCGTGCATATGTTGACCTTTGCAAAATGACCTGGTGACATGGCAAGTCAGTGGGGACAGGAAGGACCACTCCCTAAGTAATCCCAGAAC
AATGGCTATTCATGTGGGAAAAAAAGAAATTTTACTTTCTCTCACCTTACCTGGTGATAAGTTCCAAATATGTTAAGGGCTTTAATACAA
AAAGCAAAAATTGTCAGTGTTTGGATGAAAAAAGCCTTAGGGCAGGAAAGAATCTCTTGAGACATAAAGTAGTAATCATAAAGGACAAGA
TGGTTAAGTCAATTCTGTTAAAACTCAAGGCTTATATTAAGCAAACACTTGAAGTGAGAAGATGATCCACAACTTGAGAAGACATTTATA
ATACAAATAACTGATGAAGGATTCATAATCACAAATATAGAGAATTCCTATTTAAAAAAATAGAAAAATAGTGAAGACTACACAAGAGGA
AATAGGGCTTTTAAATAAATAGATGTTCTGTAGCATTGGTCAGGGAAATATGAATTAGGACCACAATGAGATTCCATTTTATATCCATAA
GATTTGCAAAGGTTGGGTCTGACAGTACCAGTTGTTAGATCTGTAGGGACTTGTACAACATTGTGGATGTGTAAACAGGCACCACTGCTT
TAAAAAACAATTATCCCTTACAGACTTGAACATTTGCAGACGTTATGATCTTGCTTCCAACTCCCACCTGTATGTCCAGCAAACTCTTGC
ATGTGGCCACTAGGAGGAATGTGTAAGAATGTTCATAGTTACATATTTATAATAGTTAATAACTGGAAAAAGTGAAATGTATGTCTGTCT
ACAGGAAAATAGGTGAATAATTAGATATATATATTCATTCTACGGGATATTATTCAGTAGTGGAAATGAGTGAACTACAGCTATACCTCA
CAATAAGAATGAATCTCAGAAAATATTAAGGAAAAAAGCAAGTTTGAAGAGACCACATGGGGCGTACTATTTTTATTGAGCCCAAAAACA
AGCAAAACCAAAGAATATGTAGTCTAAGCATACGTATACAATAAAACTATGCTATTAAAAAAAAAGAAGGTAACTGATAAACCAAAATTG
AGCATAGTAATTACCCACAGAAGGAGGAAGTGGAAGGGACAGGAGCACATAGGTAGATGCCAAGTTATGCAGCTGTTCTGGTTCCTCCTG
GTAGGCTTACAAGTGTTTACTATATGCTATTAATACATTATACTTTATAACTAATAGATAACAGTTTTTTACATATTAAATATGTTCTAC
TTAAATATATTATAAAAAATAAAGGCAAAGTGGAATGATAACCTAAAATCTGGTATGGTGATTTTGTAGGTAATGTTTGTATATGTCAAA
TACAGTTTTTAAGGAAAGGAAGAACATCTTAGGGTAAACAGCAGCTAGAAAGGTGAGGGGCAGGAGAGTGGTGCATCCTTGCTGCTGCCA
GCAGTGCCCAGATACCAGGCTTTGGGGAATGAGTGGATGGCTGGACCATTTGCTAAGACAGAGGCCAGGGGATGGGAGAAATGATGAGTT
TTGGAAAGATTCGATGTGACTAGACTGAATATAGGCAGTTGGATACTAGACTTTGGAATTTAAAAAGAATGTCTGGAGTTAGAATTGAGA
GACTTGAACGTGGAGATGGAGGTCAGGCTGCAGTGCGATGGGATCATCTATGGAGCATATGAGGAGAAGAGAATCTGGAGGAGGAGGAGG
GGGAGCCAGCAGGGGAGCAGCTGTGGGTTGGAGGAAGCCAGGAGGGAGAGTGCAATGCCGAGAAAGCAATGAAGAGCGTTTCGAAGCATG
CCAGCAGAACCCAATGCTGCAAAGAGGCCTGGGAATGGGATTGCTGAGGGCCCTTCTCACAGTGAGCCCCTCAAGAGCAGCGTCAGGGGA
TTGTGGGGACTGTTGGCACACAGCTGGCTTTGCTAGGTTGAAGACAATGGGAGGTGTGGAAGACTTGTTGACTCATTTAAAGAAGATTGG
AGGGAAAGGTAGGATTGAGAGTGTTTCAGACAGAAAAAGGATTATATGCTGAGGGTAAAGCACAAGTACAGAGGGTTGCAGATAGTGCAG
AAGTCTTTAAAAACAATTATTTTAACCCAACTTCCAGGGAGACTGAATTTCTTCTGCCAGTCAGTAACACCATCAACCTGGGAGTTGCCC
CTGACCCCTCCAGTCTTAGCTCCTGCTCCTGTAACAAAATACCACAAACTGGTTAGCTTATAGAGAACAGATGTTTATTTCTTACAGTTC
AGGAGTCTGGAAGTCCAAGATCATGGTGCCATCATGGCCGAGTTCTGGTGAGGGCCCTCTTCTGGGATGCAGCGGCCAGCTTCTCATGTT
CTCACAGTGGGTGGAGGGTAAGCTTGCTCTCTGGCCTCCTCTTAAAAAGGCACTAATCCCATTCATGAGGGCTCCACCTTCATGACCTAA
TTACCTCCCAAAGATGCCATCTCCAAACACCATCATTCTGGGGATTCCATTTCAACATGATTTGGGGGATACATCAGACCATAACACTTT
TCTTTTTCTCAACCTTCACATCCAGTTGGTTCTCAAGCCCTGGCGATTTTACGCGCTAGATAGGTCTTAAGTTCATCTCTACGCCTGCCC
TGGTTAAGGTTCTCATCATTTCTCCTCTGGATTCATCTGCAACACAGGCTGCCGGGTTGGTTCCCACCTCCTAGAGCTGGAAGAGTGGGC
TCTCTGATTCTTTACACCCCCGCCTCAATCCTCCTGCTGCCTGAATAACCATCTCCCCGTGACCTAGGATATATCCCAGCCCCTTAGAGG
CATGCAAAGCCTTCCATGTCTGACCCTGCCTCATGTCTTGGAAGCCCTAGACTGCTGCTGTACCCTGAAGGAGGTACCTGCTCACATTGG
CCCCTCTGTCTGGAATAACCCCACCCCGGTTCCACCCAAGTCAGGAAAGCTTCCCAACCCCTCCCTCCCACCACCCCAAAGCTAAGTGAA
GTGACCCCTCTTCTTGCCTCTGTAACACCGCCATGCACATTTCATACAGCCCTTGCTGAAACTTCATCTAGTTCTCTGTTAGACTTAACA
TTCCCTAAGGGCAGGTTTGGAACCTTACTCATCTTTATATGGCGTCTAAAATAGTGCTTGCTTTATGATAGGTGCTCAGTAAAGGTTGTC
TTGAATTGAGCAGATCCTCTAGGGACAGGAGTTGGATGGAGAGCAGACTGTAAAGCCTCATGAGGGCAGGGGCCCTGCCTCTTCCTGAGC
TCAGGATACCCAGAGCCTAGCTCAGTGCCTGCCATGAAATTGTTCACTCCATCAAGCCTTGTTAAATGAGTTCGGGGCGGGGGGAGCATG
ATGGTTTTCTCTCTCTCAGAAAGAAAGCGCTGTATCAAAGCCCTAGCACCCTCTCTACACCCACCTTCAGTATTTCATATTAGATGCGGC
CCAAGTGATACTTTCTTTACCGTCCCGTGAAGACAGCATATTGGCAGCCCTGCAAAAACAAAACAAAACAAAACCCTCAGTTCATGGCAT
ACTTGCTATAAATCAGCTATGTGTATTGTCAAATTGTAGAACTGAAAGTATATTCTGATTCGGTGTGTGTATAAGGAAATATACACCAGT
ATATGCATTAAAACGTCAAGAAGAGCTGGGCACAGTGTCACATGCCTGTAAACCCAGCTATTCAGGAGGCTGAGGTGGGAGGATCGGTTG
AGGCCAGGAGTTTGAGGCTGCAGTGAGCTATGATTGCACAGCTGCACTCCAGCCTGTGCTGAGACCTCATCTCTTAAAAAATAAAAAATA
AAAAGTCTAAGAGGATACACAGAAATTTTTAAGTGGTTACCTCCACGGAATGGGATTAGGGGATCAGAGGTGAGGGAACTCATGGTTTGG
CTATTTCTCGTTCTTTCTGCACTGTTTCAAATTTTTACAAGTGTATGTTATTGTACTTTTAAAAAGATTAGCTTGGCAACAAGTCTAGCC
TGAAATGGGTGCTATTTTGACTAGTCTGAGTGAAAAGTGAGGATTTAAATGAAGTAACCCCTAAACTCAGCCAGTCCCATGTTTTTTTAA
CACTTGGAATATCTAATTCCATTTACACTGCATTCTTCAAATGTAATTTTCAAAGATGCCTTTTGCCTCATCCCTTGCTTTTAAGTATTA
TTATAGACTTTTGGAGACTCACGAAACAAGCAATCCCTAAATTCTCGCCCAGGAAAGTATCTTGGATTAAATGGTTTTTGAGAACCTTGA
GAGTGTATATTCTATGAAATGGAAGAAACAAGAACTAGACAGAGTCACAAATGCTGTTGATCACAGACAATCTCTGCCATCCATAAGGTA
AATGTAATACATCTGGCGACCTGCTGAGTGTGAACTTGCAGCAGGTGAGGAAGGAACTCTGAACTCTCACAATCTTGTTTCTTCATTTCC
CAGAGAGAAACTCGGCAAAGAGAAAAAGGACATTTCCCTCCAGGTTATCTGAAAGAATTTCAATGCTTACCTTTAATCATGTGACATTGT
TTATCTTGGATTAAAAGAAAAGAAAATGTATTTATTTTGTGCATATTTTCAATAAAATATATAAAATCGAGTTGGTATATAGTGCCAAAT

>78806_78806_1_RYR2-MTR_RYR2_chr1_237551483_ENST00000360064_MTR_chr1_237044055_ENST00000366577_length(amino acids)=656AA_BP=255
LGPRSSSNKLSNKKMMKWFCSAPQPSTKNNRSYAWQQKDLATDFVSWSPLPIPRMCPQTSPSAPLCWSSPSLSGRCRRCWLTPWRNQKGQ
LDIIKWSFGLKTAQGGGHRTLLYGHAILLRHSYSGMYLCCLSTSRSSTDKLAFDVGLQEDTTGEACWWTIHPASKQRSEGEKVRVGDDLI
LVSVSSERYLHLSYGNGSLHVDAAFQQTLWSVAPISSGSEAAQGYLIGGDVLRLLHGHMDECLTVPSGEHGEEQRRTHTAVKIAPRYSAP
VIHVLDASKSVVVCSQLLDENLKDEYFEEIMEEYEDIRQDHYESLKERRYLPLSQARKSGFQMDWLSEPHPVKPTFIGTQVFEDYDLQKL
VDYIDWKPFFDVWQLRGKYPNRGFPKIFNDKTVGGEARKVYDDAHNMLNTLISQKKLRARGVVGFWPAQSIQDDIHLYAEAAVPQAAEPI
ATFYGLRQQAEKDSASTEPYYCLSDFIAPLHSGIRDYLGLFAVACFGVEELSKAYEDDGDDYSSIMVKALGDRLAEAFAEELHERVRREL
WAYCGSEQLDVADLRRLRYKGIRPAPGYPSQPDHTEKLTMWRLADIEQSTGIRLTESLAMAPASAVSGLYFSNLKSKYFAVGKISKDQVE

--------------------------------------------------------------
>78806_78806_2_RYR2-MTR_RYR2_chr1_237551483_ENST00000366574_MTR_chr1_237044055_ENST00000366577_length(transcript)=8631nt_BP=1090nt
CCGAGCGGACCGCCGGCTGCAGGCAGCGAGCGCGGCTGGGCTGCGGGGCTGCTTCCCCGCGTCCTCCGGGCCCGGGCCGCCCTCCTCCCG
CACAGTGCGGAGCAGGGAGGCCCCGCGCCTCGACCACCCGCGCCCGAGCGTCCGCGCCTCCTCCTCCGCTCTGCAGGCGGGGACCGCCCG
GCGCTCGGCACCCGGCAGCGCGGCCCCCTCCAGCCCCCGGCTCCCGGCAGCAGAAGCAGAAGGCAGCGCCAGGGGCCGCCGCCGCCGCCG
AGCTCCGCGGGGCTCGGGAGCCGGCCCCGGCGAGGAGGCGCGGAACCATGGCCGATGGGGGCGAGGGCGAAGACGAGATCCAGTTCCTGC
GAACTGATGATGAAGTGGTTCTGCAGTGCACCGCAACCATCCACAAAGAACAACAGAAGCTATGCTTGGCAGCAGAAGGATTTGGCAACA
GACTTTGTTTCTTGGAGTCCACTTCCAATTCCAAGAATGTGCCCCCAGACCTCTCCATCTGCACCTTTGTGCTGGAGCAGTCCCTCTCTG
TCCGGGCGCTGCAGGAGATGCTGGCTAACACCGTGGAGAAATCAGAAGGGCAAGTTGATGTGGAAAAATGGAAATTCATGATGAAGACTG
CTCAAGGTGGTGGTCATCGAACACTCCTCTACGGACATGCCATATTGCTGCGCCATTCCTATAGTGGCATGTATCTGTGCTGCCTGTCCA
CCTCCCGGTCTTCAACTGATAAGCTGGCTTTTGATGTTGGCTTGCAAGAGGACACCACAGGGGAGGCTTGTTGGTGGACCATACACCCTG
CCTCTAAGCAGCGATCAGAAGGAGAAAAAGTACGAGTTGGAGATGACCTCATCTTAGTTAGCGTGTCCTCTGAAAGGTACTTGCACTTGT
CTTATGGCAACGGCAGCTTACACGTGGATGCCGCTTTCCAGCAGACTCTCTGGAGCGTGGCCCCAATCAGCTCAGGAAGTGAGGCAGCCC
AAGGGTATCTCATTGGTGGTGATGTCCTCAGGTTGCTGCATGGACACATGGACGAGTGTCTCACTGTCCCTTCAGGAGAACATGGTGAAG
AGCAGCGGAGAACCCACACAGCAGTTAAAATAGCTCCGAGATACAGTGCACCTGTAATCCATGTCCTGGACGCGTCCAAGAGTGTGGTGG
TGTGTTCCCAGCTGTTAGATGAAAATCTAAAGGATGAATACTTTGAGGAAATCATGGAAGAATATGAAGATATTAGACAGGACCATTATG
AGTCTCTCAAGGAGAGGAGATACTTACCCTTAAGTCAAGCCAGAAAAAGTGGTTTCCAAATGGATTGGCTGTCTGAACCTCACCCAGTGA
AGCCCACGTTTATTGGGACCCAGGTCTTTGAAGACTATGACCTGCAGAAGCTGGTGGACTACATTGACTGGAAGCCTTTCTTTGATGTCT
GGCAGCTCCGGGGCAAGTACCCGAATCGAGGCTTTCCCAAGATATTTAACGACAAAACAGTAGGTGGAGAGGCCAGGAAGGTCTACGATG
ATGCCCACAATATGCTGAACACACTGATTAGTCAAAAGAAACTCCGGGCCCGGGGTGTGGTTGGGTTCTGGCCAGCACAGAGTATCCAAG
ACGACATTCACCTGTACGCAGAGGCTGCTGTGCCCCAGGCTGCAGAGCCCATAGCCACCTTCTATGGGTTAAGGCAACAGGCTGAGAAGG
ACTCTGCCAGCACGGAGCCATACTACTGCCTCTCAGACTTCATCGCTCCCTTGCATTCTGGCATCCGTGACTACCTGGGCCTGTTTGCCG
TTGCCTGCTTTGGGGTAGAAGAGCTGAGCAAGGCCTATGAGGATGATGGTGACGACTACAGCAGCATCATGGTCAAGGCGCTGGGGGACC
GGCTGGCAGAGGCCTTTGCAGAAGAGCTCCATGAAAGAGTTCGCCGAGAACTGTGGGCCTACTGTGGCAGTGAGCAGCTGGACGTCGCAG
ACCTGCGCAGGCTGCGGTACAAGGGCATCCGCCCGGCTCCTGGCTACCCCAGCCAGCCCGACCACACCGAGAAGCTCACCATGTGGAGAC
TCGCAGACATCGAGCAGTCTACAGGCATTAGGTTAACAGAATCATTAGCAATGGCACCTGCTTCAGCAGTCTCAGGCCTCTACTTCTCCA
ATTTGAAGTCCAAATATTTTGCTGTGGGGAAGATTTCCAAGGATCAGGTTGAGGATTATGCATTGAGGAAGAACATATCTGTGGCTGAGG
TTGAGAAATGGCTTGGACCCATTTTGGGATATGATACAGACTAACTTTTTTTTTTTTTTTGCCTTTTTTATTCTTGATGATCCTCAAGGA
AATACAACCTAGGGTGCCTTAAAAATAACAACAACAAAAAACCTGTGTGCATCTGGCTGACACTTACCTGCTTCTGGTTTTCGAAGACTA
TTTAGTGGAACCTTGTAGAGGAGCAGGGTCTTCCTGCAGTGCCTGGAAAACAGGCGCTGTTTTTTTGGGACCTTGCGTGAAGAGCAGTGA
GCAGGGTTCCTGTGGTTTCCCTGGTCCCTCTGAGATGGGGACAGACTGAAGACAGAGGTCGTTTGATTTCAAAGCAAGTCAACCTGCTTT
TTTCTGTTTTTACAGTGGAATCTAGGAGGCCACTTAGTCGTCTTTTTTTCCTCTTAGAAGAAAAGCCTGAAACTGAGTTGAATAGAGAAG
TGTGACCCTGTGACAAAATGATACTGTGAGAAATGGGGCATTTTAATCTAAGTGGTTATAACAGTGGATTCTGACGGGGAAGGTGTAGCT
CTGTTCTCTTCGGAAGACCTCGTTTTCTAAAGGCTGGACTAAATGGCTGCAGAACTCCCTTTGGCAAAAGGCATGCGCTCACTGCTTGCT
TGTCAGAAACACTGAAGCCATTTGCCCCAGTGTGGTCAAGCAGCCATGCTTTCTGGGCATTTTCGTCCTCCCATAATTTCATATTTCCGT
ACCCCTGAGGAAACAAAAAGGAAATGAGGAGAGAAAGTTACTGTTAAGGGTGGTTAACATTTTTTTTGTTTTGTTTTGTTTTGGTTTTTT
TTTTTTTGAGACAGAGTCTGGCTCTGTCGCCCAGGCTGGAGTGCAGGGGCGCAATCTCGGCTCATAGCAAGCTCCGCCTCCTGGGTTCAT
GCCATTCTCCTGCCTCAGCCTCCAGAGTAGCTGGGACTACAGGTGCCCGCCACCACACCCGGCTAATTTTTTGTGTTTTTACAAAATACA
AAAAAGTAGAGACAGGATTTCACTGTGTTAGCCAGGATGGTCTTGATCTCCCGACCTCGTGATCTGCCCACCTCAGCCTCCCAAAATGCT
GGGATTACAGGCGTGAGCCACCGAGCCTGGCCGGTTAACATCTTTTAATTGTTTCCAGGATTGAGCAGGTTCTCAGCTGGGCTCTGATAT
CCCGTGCGGAGTTGGACAAGTGGGCAGCATAAAGTCACTCATTTCTTACCATTTTATTCCCCTCAATTCTCAATATATTCAGTAATGAAG
AATGGTGCCACCACTCAAGCAACAAGCCTCAAACTCAACCATGTCATCTTTTTCTTGGATGATTGCAGTTATTTCAAAAATTTGCATGCA
AAATATACACTCATCCTACTTCAAGATGGTGGTGGCAATAGTCAGGAGAAGGTAACATTGGAGTCCTGGTTTGATTCGAAGGATGAAGAC
GAAGAAGCAAGGGAGGAACAAATGAAGAACCATCTTTGTTCATGAATAGGAATATTCAAGATTATAAAGGTATCAGGTCTCCTAAAATTG
ATCTATGGATTTAATACCATTTTCAATGGAAATTCCAACAGATTTTATTGAATGAAACAAGCAGGTGTTTATATGGAGTAGCAAAGGACT
TAAAATTACCAAATGCTTCTAAATATGAAGGAGAGGTTGGGGACACGCACCCTATGTGATACCAAGTTTTATTGTCAAGACAGTGTCATG
GTGCAGAGGTAGGCATTCTGAGCAGGGGAACAAAATAAGGGCCTAGAAACTCACCCGTGCATATGTTGACCTTTGCAAAATGACCTGGTG
ACATGGCAAGTCAGTGGGGACAGGAAGGACCACTCCCTAAGTAATCCCAGAACAATGGCTATTCATGTGGGAAAAAAAGAAATTTTACTT
TCTCTCACCTTACCTGGTGATAAGTTCCAAATATGTTAAGGGCTTTAATACAAAAAGCAAAAATTGTCAGTGTTTGGATGAAAAAAGCCT
TAGGGCAGGAAAGAATCTCTTGAGACATAAAGTAGTAATCATAAAGGACAAGATGGTTAAGTCAATTCTGTTAAAACTCAAGGCTTATAT
TAAGCAAACACTTGAAGTGAGAAGATGATCCACAACTTGAGAAGACATTTATAATACAAATAACTGATGAAGGATTCATAATCACAAATA
TAGAGAATTCCTATTTAAAAAAATAGAAAAATAGTGAAGACTACACAAGAGGAAATAGGGCTTTTAAATAAATAGATGTTCTGTAGCATT
GGTCAGGGAAATATGAATTAGGACCACAATGAGATTCCATTTTATATCCATAAGATTTGCAAAGGTTGGGTCTGACAGTACCAGTTGTTA
GATCTGTAGGGACTTGTACAACATTGTGGATGTGTAAACAGGCACCACTGCTTTAAAAAACAATTATCCCTTACAGACTTGAACATTTGC
AGACGTTATGATCTTGCTTCCAACTCCCACCTGTATGTCCAGCAAACTCTTGCATGTGGCCACTAGGAGGAATGTGTAAGAATGTTCATA
GTTACATATTTATAATAGTTAATAACTGGAAAAAGTGAAATGTATGTCTGTCTACAGGAAAATAGGTGAATAATTAGATATATATATTCA
TTCTACGGGATATTATTCAGTAGTGGAAATGAGTGAACTACAGCTATACCTCACAATAAGAATGAATCTCAGAAAATATTAAGGAAAAAA
GCAAGTTTGAAGAGACCACATGGGGCGTACTATTTTTATTGAGCCCAAAAACAAGCAAAACCAAAGAATATGTAGTCTAAGCATACGTAT
ACAATAAAACTATGCTATTAAAAAAAAAGAAGGTAACTGATAAACCAAAATTGAGCATAGTAATTACCCACAGAAGGAGGAAGTGGAAGG
GACAGGAGCACATAGGTAGATGCCAAGTTATGCAGCTGTTCTGGTTCCTCCTGGTAGGCTTACAAGTGTTTACTATATGCTATTAATACA
TTATACTTTATAACTAATAGATAACAGTTTTTTACATATTAAATATGTTCTACTTAAATATATTATAAAAAATAAAGGCAAAGTGGAATG
ATAACCTAAAATCTGGTATGGTGATTTTGTAGGTAATGTTTGTATATGTCAAATACAGTTTTTAAGGAAAGGAAGAACATCTTAGGGTAA
ACAGCAGCTAGAAAGGTGAGGGGCAGGAGAGTGGTGCATCCTTGCTGCTGCCAGCAGTGCCCAGATACCAGGCTTTGGGGAATGAGTGGA
TGGCTGGACCATTTGCTAAGACAGAGGCCAGGGGATGGGAGAAATGATGAGTTTTGGAAAGATTCGATGTGACTAGACTGAATATAGGCA
GTTGGATACTAGACTTTGGAATTTAAAAAGAATGTCTGGAGTTAGAATTGAGAGACTTGAACGTGGAGATGGAGGTCAGGCTGCAGTGCG
ATGGGATCATCTATGGAGCATATGAGGAGAAGAGAATCTGGAGGAGGAGGAGGGGGAGCCAGCAGGGGAGCAGCTGTGGGTTGGAGGAAG
CCAGGAGGGAGAGTGCAATGCCGAGAAAGCAATGAAGAGCGTTTCGAAGCATGCCAGCAGAACCCAATGCTGCAAAGAGGCCTGGGAATG
GGATTGCTGAGGGCCCTTCTCACAGTGAGCCCCTCAAGAGCAGCGTCAGGGGATTGTGGGGACTGTTGGCACACAGCTGGCTTTGCTAGG
TTGAAGACAATGGGAGGTGTGGAAGACTTGTTGACTCATTTAAAGAAGATTGGAGGGAAAGGTAGGATTGAGAGTGTTTCAGACAGAAAA
AGGATTATATGCTGAGGGTAAAGCACAAGTACAGAGGGTTGCAGATAGTGCAGAAGTCTTTAAAAACAATTATTTTAACCCAACTTCCAG
GGAGACTGAATTTCTTCTGCCAGTCAGTAACACCATCAACCTGGGAGTTGCCCCTGACCCCTCCAGTCTTAGCTCCTGCTCCTGTAACAA
AATACCACAAACTGGTTAGCTTATAGAGAACAGATGTTTATTTCTTACAGTTCAGGAGTCTGGAAGTCCAAGATCATGGTGCCATCATGG
CCGAGTTCTGGTGAGGGCCCTCTTCTGGGATGCAGCGGCCAGCTTCTCATGTTCTCACAGTGGGTGGAGGGTAAGCTTGCTCTCTGGCCT
CCTCTTAAAAAGGCACTAATCCCATTCATGAGGGCTCCACCTTCATGACCTAATTACCTCCCAAAGATGCCATCTCCAAACACCATCATT
CTGGGGATTCCATTTCAACATGATTTGGGGGATACATCAGACCATAACACTTTTCTTTTTCTCAACCTTCACATCCAGTTGGTTCTCAAG
CCCTGGCGATTTTACGCGCTAGATAGGTCTTAAGTTCATCTCTACGCCTGCCCTGGTTAAGGTTCTCATCATTTCTCCTCTGGATTCATC
TGCAACACAGGCTGCCGGGTTGGTTCCCACCTCCTAGAGCTGGAAGAGTGGGCTCTCTGATTCTTTACACCCCCGCCTCAATCCTCCTGC
TGCCTGAATAACCATCTCCCCGTGACCTAGGATATATCCCAGCCCCTTAGAGGCATGCAAAGCCTTCCATGTCTGACCCTGCCTCATGTC
TTGGAAGCCCTAGACTGCTGCTGTACCCTGAAGGAGGTACCTGCTCACATTGGCCCCTCTGTCTGGAATAACCCCACCCCGGTTCCACCC
AAGTCAGGAAAGCTTCCCAACCCCTCCCTCCCACCACCCCAAAGCTAAGTGAAGTGACCCCTCTTCTTGCCTCTGTAACACCGCCATGCA
CATTTCATACAGCCCTTGCTGAAACTTCATCTAGTTCTCTGTTAGACTTAACATTCCCTAAGGGCAGGTTTGGAACCTTACTCATCTTTA
TATGGCGTCTAAAATAGTGCTTGCTTTATGATAGGTGCTCAGTAAAGGTTGTCTTGAATTGAGCAGATCCTCTAGGGACAGGAGTTGGAT
GGAGAGCAGACTGTAAAGCCTCATGAGGGCAGGGGCCCTGCCTCTTCCTGAGCTCAGGATACCCAGAGCCTAGCTCAGTGCCTGCCATGA
AATTGTTCACTCCATCAAGCCTTGTTAAATGAGTTCGGGGCGGGGGGAGCATGATGGTTTTCTCTCTCTCAGAAAGAAAGCGCTGTATCA
AAGCCCTAGCACCCTCTCTACACCCACCTTCAGTATTTCATATTAGATGCGGCCCAAGTGATACTTTCTTTACCGTCCCGTGAAGACAGC
ATATTGGCAGCCCTGCAAAAACAAAACAAAACAAAACCCTCAGTTCATGGCATACTTGCTATAAATCAGCTATGTGTATTGTCAAATTGT
AGAACTGAAAGTATATTCTGATTCGGTGTGTGTATAAGGAAATATACACCAGTATATGCATTAAAACGTCAAGAAGAGCTGGGCACAGTG
TCACATGCCTGTAAACCCAGCTATTCAGGAGGCTGAGGTGGGAGGATCGGTTGAGGCCAGGAGTTTGAGGCTGCAGTGAGCTATGATTGC
ACAGCTGCACTCCAGCCTGTGCTGAGACCTCATCTCTTAAAAAATAAAAAATAAAAAGTCTAAGAGGATACACAGAAATTTTTAAGTGGT
TACCTCCACGGAATGGGATTAGGGGATCAGAGGTGAGGGAACTCATGGTTTGGCTATTTCTCGTTCTTTCTGCACTGTTTCAAATTTTTA
CAAGTGTATGTTATTGTACTTTTAAAAAGATTAGCTTGGCAACAAGTCTAGCCTGAAATGGGTGCTATTTTGACTAGTCTGAGTGAAAAG
TGAGGATTTAAATGAAGTAACCCCTAAACTCAGCCAGTCCCATGTTTTTTTAACACTTGGAATATCTAATTCCATTTACACTGCATTCTT
CAAATGTAATTTTCAAAGATGCCTTTTGCCTCATCCCTTGCTTTTAAGTATTATTATAGACTTTTGGAGACTCACGAAACAAGCAATCCC
TAAATTCTCGCCCAGGAAAGTATCTTGGATTAAATGGTTTTTGAGAACCTTGAGAGTGTATATTCTATGAAATGGAAGAAACAAGAACTA
GACAGAGTCACAAATGCTGTTGATCACAGACAATCTCTGCCATCCATAAGGTAAATGTAATACATCTGGCGACCTGCTGAGTGTGAACTT
GCAGCAGGTGAGGAAGGAACTCTGAACTCTCACAATCTTGTTTCTTCATTTCCCAGAGAGAAACTCGGCAAAGAGAAAAAGGACATTTCC
CTCCAGGTTATCTGAAAGAATTTCAATGCTTACCTTTAATCATGTGACATTGTTTATCTTGGATTAAAAGAAAAGAAAATGTATTTATTT

>78806_78806_2_RYR2-MTR_RYR2_chr1_237551483_ENST00000366574_MTR_chr1_237044055_ENST00000366577_length(amino acids)=752AA_BP=351
MGCGAASPRPPGPGRPPPAQCGAGRPRASTTRARASAPPPPLCRRGPPGARHPAARPPPAPGSRQQKQKAAPGAAAAAELRGAREPAPAR
RRGTMADGGEGEDEIQFLRTDDEVVLQCTATIHKEQQKLCLAAEGFGNRLCFLESTSNSKNVPPDLSICTFVLEQSLSVRALQEMLANTV
EKSEGQVDVEKWKFMMKTAQGGGHRTLLYGHAILLRHSYSGMYLCCLSTSRSSTDKLAFDVGLQEDTTGEACWWTIHPASKQRSEGEKVR
VGDDLILVSVSSERYLHLSYGNGSLHVDAAFQQTLWSVAPISSGSEAAQGYLIGGDVLRLLHGHMDECLTVPSGEHGEEQRRTHTAVKIA
PRYSAPVIHVLDASKSVVVCSQLLDENLKDEYFEEIMEEYEDIRQDHYESLKERRYLPLSQARKSGFQMDWLSEPHPVKPTFIGTQVFED
YDLQKLVDYIDWKPFFDVWQLRGKYPNRGFPKIFNDKTVGGEARKVYDDAHNMLNTLISQKKLRARGVVGFWPAQSIQDDIHLYAEAAVP
QAAEPIATFYGLRQQAEKDSASTEPYYCLSDFIAPLHSGIRDYLGLFAVACFGVEELSKAYEDDGDDYSSIMVKALGDRLAEAFAEELHE
RVRRELWAYCGSEQLDVADLRRLRYKGIRPAPGYPSQPDHTEKLTMWRLADIEQSTGIRLTESLAMAPASAVSGLYFSNLKSKYFAVGKI

--------------------------------------------------------------
>78806_78806_3_RYR2-MTR_RYR2_chr1_237551483_ENST00000542537_MTR_chr1_237044055_ENST00000366577_length(transcript)=8266nt_BP=725nt
GATGATGAAGTGGTTCTGCAGTGCACCGCAACCATCCACAAAGAACAACAGAAGCTATGCTTGGCAGCAGAAGGATTTGGCAACAGACTT
TGTTTCTTGGAGTCCACTTCCAATTCCAAGAATGTGCCCCCAGACCTCTCCATCTGCACCTTTGTGCTGGAGCAGTCCCTCTCTGTCCGG
GCGCTGCAGGAGATGCTGGCTAACACCGTGGAGAAATCAGAAGGGCAAGTTGATGTGGAAAAATGGAAATTCATGATGAAGACTGCTCAA
GGTGGTGGTCATCGAACACTCCTCTACGGACATGCCATATTGCTGCGCCATTCCTATAGTGGCATGTATCTGTGCTGCCTGTCCACCTCC
CGGTCTTCAACTGATAAGCTGGCTTTTGATGTTGGCTTGCAAGAGGACACCACAGGGGAGGCTTGTTGGTGGACCATACACCCTGCCTCT
AAGCAGCGATCAGAAGGAGAAAAAGTACGAGTTGGAGATGACCTCATCTTAGTTAGCGTGTCCTCTGAAAGGTACTTGCACTTGTCTTAT
GGCAACGGCAGCTTACACGTGGATGCCGCTTTCCAGCAGACTCTCTGGAGCGTGGCCCCAATCAGCTCAGGAAGTGAGGCAGCCCAAGGG
TATCTCATTGGTGGTGATGTCCTCAGGTTGCTGCATGGACACATGGACGAGTGTCTCACTGTCCCTTCAGGAGAACATGGTGAAGAGCAG
CGGAGAACCCACACAGCAGTTAAAATAGCTCCGAGATACAGTGCACCTGTAATCCATGTCCTGGACGCGTCCAAGAGTGTGGTGGTGTGT
TCCCAGCTGTTAGATGAAAATCTAAAGGATGAATACTTTGAGGAAATCATGGAAGAATATGAAGATATTAGACAGGACCATTATGAGTCT
CTCAAGGAGAGGAGATACTTACCCTTAAGTCAAGCCAGAAAAAGTGGTTTCCAAATGGATTGGCTGTCTGAACCTCACCCAGTGAAGCCC
ACGTTTATTGGGACCCAGGTCTTTGAAGACTATGACCTGCAGAAGCTGGTGGACTACATTGACTGGAAGCCTTTCTTTGATGTCTGGCAG
CTCCGGGGCAAGTACCCGAATCGAGGCTTTCCCAAGATATTTAACGACAAAACAGTAGGTGGAGAGGCCAGGAAGGTCTACGATGATGCC
CACAATATGCTGAACACACTGATTAGTCAAAAGAAACTCCGGGCCCGGGGTGTGGTTGGGTTCTGGCCAGCACAGAGTATCCAAGACGAC
ATTCACCTGTACGCAGAGGCTGCTGTGCCCCAGGCTGCAGAGCCCATAGCCACCTTCTATGGGTTAAGGCAACAGGCTGAGAAGGACTCT
GCCAGCACGGAGCCATACTACTGCCTCTCAGACTTCATCGCTCCCTTGCATTCTGGCATCCGTGACTACCTGGGCCTGTTTGCCGTTGCC
TGCTTTGGGGTAGAAGAGCTGAGCAAGGCCTATGAGGATGATGGTGACGACTACAGCAGCATCATGGTCAAGGCGCTGGGGGACCGGCTG
GCAGAGGCCTTTGCAGAAGAGCTCCATGAAAGAGTTCGCCGAGAACTGTGGGCCTACTGTGGCAGTGAGCAGCTGGACGTCGCAGACCTG
CGCAGGCTGCGGTACAAGGGCATCCGCCCGGCTCCTGGCTACCCCAGCCAGCCCGACCACACCGAGAAGCTCACCATGTGGAGACTCGCA
GACATCGAGCAGTCTACAGGCATTAGGTTAACAGAATCATTAGCAATGGCACCTGCTTCAGCAGTCTCAGGCCTCTACTTCTCCAATTTG
AAGTCCAAATATTTTGCTGTGGGGAAGATTTCCAAGGATCAGGTTGAGGATTATGCATTGAGGAAGAACATATCTGTGGCTGAGGTTGAG
AAATGGCTTGGACCCATTTTGGGATATGATACAGACTAACTTTTTTTTTTTTTTTGCCTTTTTTATTCTTGATGATCCTCAAGGAAATAC
AACCTAGGGTGCCTTAAAAATAACAACAACAAAAAACCTGTGTGCATCTGGCTGACACTTACCTGCTTCTGGTTTTCGAAGACTATTTAG
TGGAACCTTGTAGAGGAGCAGGGTCTTCCTGCAGTGCCTGGAAAACAGGCGCTGTTTTTTTGGGACCTTGCGTGAAGAGCAGTGAGCAGG
GTTCCTGTGGTTTCCCTGGTCCCTCTGAGATGGGGACAGACTGAAGACAGAGGTCGTTTGATTTCAAAGCAAGTCAACCTGCTTTTTTCT
GTTTTTACAGTGGAATCTAGGAGGCCACTTAGTCGTCTTTTTTTCCTCTTAGAAGAAAAGCCTGAAACTGAGTTGAATAGAGAAGTGTGA
CCCTGTGACAAAATGATACTGTGAGAAATGGGGCATTTTAATCTAAGTGGTTATAACAGTGGATTCTGACGGGGAAGGTGTAGCTCTGTT
CTCTTCGGAAGACCTCGTTTTCTAAAGGCTGGACTAAATGGCTGCAGAACTCCCTTTGGCAAAAGGCATGCGCTCACTGCTTGCTTGTCA
GAAACACTGAAGCCATTTGCCCCAGTGTGGTCAAGCAGCCATGCTTTCTGGGCATTTTCGTCCTCCCATAATTTCATATTTCCGTACCCC
TGAGGAAACAAAAAGGAAATGAGGAGAGAAAGTTACTGTTAAGGGTGGTTAACATTTTTTTTGTTTTGTTTTGTTTTGGTTTTTTTTTTT
TTGAGACAGAGTCTGGCTCTGTCGCCCAGGCTGGAGTGCAGGGGCGCAATCTCGGCTCATAGCAAGCTCCGCCTCCTGGGTTCATGCCAT
TCTCCTGCCTCAGCCTCCAGAGTAGCTGGGACTACAGGTGCCCGCCACCACACCCGGCTAATTTTTTGTGTTTTTACAAAATACAAAAAA
GTAGAGACAGGATTTCACTGTGTTAGCCAGGATGGTCTTGATCTCCCGACCTCGTGATCTGCCCACCTCAGCCTCCCAAAATGCTGGGAT
TACAGGCGTGAGCCACCGAGCCTGGCCGGTTAACATCTTTTAATTGTTTCCAGGATTGAGCAGGTTCTCAGCTGGGCTCTGATATCCCGT
GCGGAGTTGGACAAGTGGGCAGCATAAAGTCACTCATTTCTTACCATTTTATTCCCCTCAATTCTCAATATATTCAGTAATGAAGAATGG
TGCCACCACTCAAGCAACAAGCCTCAAACTCAACCATGTCATCTTTTTCTTGGATGATTGCAGTTATTTCAAAAATTTGCATGCAAAATA
TACACTCATCCTACTTCAAGATGGTGGTGGCAATAGTCAGGAGAAGGTAACATTGGAGTCCTGGTTTGATTCGAAGGATGAAGACGAAGA
AGCAAGGGAGGAACAAATGAAGAACCATCTTTGTTCATGAATAGGAATATTCAAGATTATAAAGGTATCAGGTCTCCTAAAATTGATCTA
TGGATTTAATACCATTTTCAATGGAAATTCCAACAGATTTTATTGAATGAAACAAGCAGGTGTTTATATGGAGTAGCAAAGGACTTAAAA
TTACCAAATGCTTCTAAATATGAAGGAGAGGTTGGGGACACGCACCCTATGTGATACCAAGTTTTATTGTCAAGACAGTGTCATGGTGCA
GAGGTAGGCATTCTGAGCAGGGGAACAAAATAAGGGCCTAGAAACTCACCCGTGCATATGTTGACCTTTGCAAAATGACCTGGTGACATG
GCAAGTCAGTGGGGACAGGAAGGACCACTCCCTAAGTAATCCCAGAACAATGGCTATTCATGTGGGAAAAAAAGAAATTTTACTTTCTCT
CACCTTACCTGGTGATAAGTTCCAAATATGTTAAGGGCTTTAATACAAAAAGCAAAAATTGTCAGTGTTTGGATGAAAAAAGCCTTAGGG
CAGGAAAGAATCTCTTGAGACATAAAGTAGTAATCATAAAGGACAAGATGGTTAAGTCAATTCTGTTAAAACTCAAGGCTTATATTAAGC
AAACACTTGAAGTGAGAAGATGATCCACAACTTGAGAAGACATTTATAATACAAATAACTGATGAAGGATTCATAATCACAAATATAGAG
AATTCCTATTTAAAAAAATAGAAAAATAGTGAAGACTACACAAGAGGAAATAGGGCTTTTAAATAAATAGATGTTCTGTAGCATTGGTCA
GGGAAATATGAATTAGGACCACAATGAGATTCCATTTTATATCCATAAGATTTGCAAAGGTTGGGTCTGACAGTACCAGTTGTTAGATCT
GTAGGGACTTGTACAACATTGTGGATGTGTAAACAGGCACCACTGCTTTAAAAAACAATTATCCCTTACAGACTTGAACATTTGCAGACG
TTATGATCTTGCTTCCAACTCCCACCTGTATGTCCAGCAAACTCTTGCATGTGGCCACTAGGAGGAATGTGTAAGAATGTTCATAGTTAC
ATATTTATAATAGTTAATAACTGGAAAAAGTGAAATGTATGTCTGTCTACAGGAAAATAGGTGAATAATTAGATATATATATTCATTCTA
CGGGATATTATTCAGTAGTGGAAATGAGTGAACTACAGCTATACCTCACAATAAGAATGAATCTCAGAAAATATTAAGGAAAAAAGCAAG
TTTGAAGAGACCACATGGGGCGTACTATTTTTATTGAGCCCAAAAACAAGCAAAACCAAAGAATATGTAGTCTAAGCATACGTATACAAT
AAAACTATGCTATTAAAAAAAAAGAAGGTAACTGATAAACCAAAATTGAGCATAGTAATTACCCACAGAAGGAGGAAGTGGAAGGGACAG
GAGCACATAGGTAGATGCCAAGTTATGCAGCTGTTCTGGTTCCTCCTGGTAGGCTTACAAGTGTTTACTATATGCTATTAATACATTATA
CTTTATAACTAATAGATAACAGTTTTTTACATATTAAATATGTTCTACTTAAATATATTATAAAAAATAAAGGCAAAGTGGAATGATAAC
CTAAAATCTGGTATGGTGATTTTGTAGGTAATGTTTGTATATGTCAAATACAGTTTTTAAGGAAAGGAAGAACATCTTAGGGTAAACAGC
AGCTAGAAAGGTGAGGGGCAGGAGAGTGGTGCATCCTTGCTGCTGCCAGCAGTGCCCAGATACCAGGCTTTGGGGAATGAGTGGATGGCT
GGACCATTTGCTAAGACAGAGGCCAGGGGATGGGAGAAATGATGAGTTTTGGAAAGATTCGATGTGACTAGACTGAATATAGGCAGTTGG
ATACTAGACTTTGGAATTTAAAAAGAATGTCTGGAGTTAGAATTGAGAGACTTGAACGTGGAGATGGAGGTCAGGCTGCAGTGCGATGGG
ATCATCTATGGAGCATATGAGGAGAAGAGAATCTGGAGGAGGAGGAGGGGGAGCCAGCAGGGGAGCAGCTGTGGGTTGGAGGAAGCCAGG
AGGGAGAGTGCAATGCCGAGAAAGCAATGAAGAGCGTTTCGAAGCATGCCAGCAGAACCCAATGCTGCAAAGAGGCCTGGGAATGGGATT
GCTGAGGGCCCTTCTCACAGTGAGCCCCTCAAGAGCAGCGTCAGGGGATTGTGGGGACTGTTGGCACACAGCTGGCTTTGCTAGGTTGAA
GACAATGGGAGGTGTGGAAGACTTGTTGACTCATTTAAAGAAGATTGGAGGGAAAGGTAGGATTGAGAGTGTTTCAGACAGAAAAAGGAT
TATATGCTGAGGGTAAAGCACAAGTACAGAGGGTTGCAGATAGTGCAGAAGTCTTTAAAAACAATTATTTTAACCCAACTTCCAGGGAGA
CTGAATTTCTTCTGCCAGTCAGTAACACCATCAACCTGGGAGTTGCCCCTGACCCCTCCAGTCTTAGCTCCTGCTCCTGTAACAAAATAC
CACAAACTGGTTAGCTTATAGAGAACAGATGTTTATTTCTTACAGTTCAGGAGTCTGGAAGTCCAAGATCATGGTGCCATCATGGCCGAG
TTCTGGTGAGGGCCCTCTTCTGGGATGCAGCGGCCAGCTTCTCATGTTCTCACAGTGGGTGGAGGGTAAGCTTGCTCTCTGGCCTCCTCT
TAAAAAGGCACTAATCCCATTCATGAGGGCTCCACCTTCATGACCTAATTACCTCCCAAAGATGCCATCTCCAAACACCATCATTCTGGG
GATTCCATTTCAACATGATTTGGGGGATACATCAGACCATAACACTTTTCTTTTTCTCAACCTTCACATCCAGTTGGTTCTCAAGCCCTG
GCGATTTTACGCGCTAGATAGGTCTTAAGTTCATCTCTACGCCTGCCCTGGTTAAGGTTCTCATCATTTCTCCTCTGGATTCATCTGCAA
CACAGGCTGCCGGGTTGGTTCCCACCTCCTAGAGCTGGAAGAGTGGGCTCTCTGATTCTTTACACCCCCGCCTCAATCCTCCTGCTGCCT
GAATAACCATCTCCCCGTGACCTAGGATATATCCCAGCCCCTTAGAGGCATGCAAAGCCTTCCATGTCTGACCCTGCCTCATGTCTTGGA
AGCCCTAGACTGCTGCTGTACCCTGAAGGAGGTACCTGCTCACATTGGCCCCTCTGTCTGGAATAACCCCACCCCGGTTCCACCCAAGTC
AGGAAAGCTTCCCAACCCCTCCCTCCCACCACCCCAAAGCTAAGTGAAGTGACCCCTCTTCTTGCCTCTGTAACACCGCCATGCACATTT
CATACAGCCCTTGCTGAAACTTCATCTAGTTCTCTGTTAGACTTAACATTCCCTAAGGGCAGGTTTGGAACCTTACTCATCTTTATATGG
CGTCTAAAATAGTGCTTGCTTTATGATAGGTGCTCAGTAAAGGTTGTCTTGAATTGAGCAGATCCTCTAGGGACAGGAGTTGGATGGAGA
GCAGACTGTAAAGCCTCATGAGGGCAGGGGCCCTGCCTCTTCCTGAGCTCAGGATACCCAGAGCCTAGCTCAGTGCCTGCCATGAAATTG
TTCACTCCATCAAGCCTTGTTAAATGAGTTCGGGGCGGGGGGAGCATGATGGTTTTCTCTCTCTCAGAAAGAAAGCGCTGTATCAAAGCC
CTAGCACCCTCTCTACACCCACCTTCAGTATTTCATATTAGATGCGGCCCAAGTGATACTTTCTTTACCGTCCCGTGAAGACAGCATATT
GGCAGCCCTGCAAAAACAAAACAAAACAAAACCCTCAGTTCATGGCATACTTGCTATAAATCAGCTATGTGTATTGTCAAATTGTAGAAC
TGAAAGTATATTCTGATTCGGTGTGTGTATAAGGAAATATACACCAGTATATGCATTAAAACGTCAAGAAGAGCTGGGCACAGTGTCACA
TGCCTGTAAACCCAGCTATTCAGGAGGCTGAGGTGGGAGGATCGGTTGAGGCCAGGAGTTTGAGGCTGCAGTGAGCTATGATTGCACAGC
TGCACTCCAGCCTGTGCTGAGACCTCATCTCTTAAAAAATAAAAAATAAAAAGTCTAAGAGGATACACAGAAATTTTTAAGTGGTTACCT
CCACGGAATGGGATTAGGGGATCAGAGGTGAGGGAACTCATGGTTTGGCTATTTCTCGTTCTTTCTGCACTGTTTCAAATTTTTACAAGT
GTATGTTATTGTACTTTTAAAAAGATTAGCTTGGCAACAAGTCTAGCCTGAAATGGGTGCTATTTTGACTAGTCTGAGTGAAAAGTGAGG
ATTTAAATGAAGTAACCCCTAAACTCAGCCAGTCCCATGTTTTTTTAACACTTGGAATATCTAATTCCATTTACACTGCATTCTTCAAAT
GTAATTTTCAAAGATGCCTTTTGCCTCATCCCTTGCTTTTAAGTATTATTATAGACTTTTGGAGACTCACGAAACAAGCAATCCCTAAAT
TCTCGCCCAGGAAAGTATCTTGGATTAAATGGTTTTTGAGAACCTTGAGAGTGTATATTCTATGAAATGGAAGAAACAAGAACTAGACAG
AGTCACAAATGCTGTTGATCACAGACAATCTCTGCCATCCATAAGGTAAATGTAATACATCTGGCGACCTGCTGAGTGTGAACTTGCAGC
AGGTGAGGAAGGAACTCTGAACTCTCACAATCTTGTTTCTTCATTTCCCAGAGAGAAACTCGGCAAAGAGAAAAAGGACATTTCCCTCCA
GGTTATCTGAAAGAATTTCAATGCTTACCTTTAATCATGTGACATTGTTTATCTTGGATTAAAAGAAAAGAAAATGTATTTATTTTGTGC

>78806_78806_3_RYR2-MTR_RYR2_chr1_237551483_ENST00000542537_MTR_chr1_237044055_ENST00000366577_length(amino acids)=637AA_BP=236
MQCTATIHKEQQKLCLAAEGFGNRLCFLESTSNSKNVPPDLSICTFVLEQSLSVRALQEMLANTVEKSEGQVDVEKWKFMMKTAQGGGHR
TLLYGHAILLRHSYSGMYLCCLSTSRSSTDKLAFDVGLQEDTTGEACWWTIHPASKQRSEGEKVRVGDDLILVSVSSERYLHLSYGNGSL
HVDAAFQQTLWSVAPISSGSEAAQGYLIGGDVLRLLHGHMDECLTVPSGEHGEEQRRTHTAVKIAPRYSAPVIHVLDASKSVVVCSQLLD
ENLKDEYFEEIMEEYEDIRQDHYESLKERRYLPLSQARKSGFQMDWLSEPHPVKPTFIGTQVFEDYDLQKLVDYIDWKPFFDVWQLRGKY
PNRGFPKIFNDKTVGGEARKVYDDAHNMLNTLISQKKLRARGVVGFWPAQSIQDDIHLYAEAAVPQAAEPIATFYGLRQQAEKDSASTEP
YYCLSDFIAPLHSGIRDYLGLFAVACFGVEELSKAYEDDGDDYSSIMVKALGDRLAEAFAEELHERVRRELWAYCGSEQLDVADLRRLRY
KGIRPAPGYPSQPDHTEKLTMWRLADIEQSTGIRLTESLAMAPASAVSGLYFSNLKSKYFAVGKISKDQVEDYALRKNISVAEVEKWLGP

--------------------------------------------------------------

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Fusion Gene PPI Analysis for RYR2-MTR


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneRYR2chr1:237551483chr1:237044055ENST00000366574+101053581_3610257.66666666666674968.0CALM


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for RYR2-MTR


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for RYR2-MTR


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource