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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:SAE1-ARHGAP35 (FusionGDB2 ID:79004)

Fusion Gene Summary for SAE1-ARHGAP35

check button Fusion gene summary
Fusion gene informationFusion gene name: SAE1-ARHGAP35
Fusion gene ID: 79004
HgeneTgene
Gene symbol

SAE1

ARHGAP35

Gene ID

10055

2909

Gene nameSUMO1 activating enzyme subunit 1Rho GTPase activating protein 35
SynonymsAOS1|HSPC140|SUA1|UBLE1AGRF-1|GRLF1|P190-A|P190A|p190ARhoGAP|p190RhoGAP
Cytomap

19q13.32

19q13.32

Type of geneprotein-codingprotein-coding
DescriptionSUMO-activating enzyme subunit 1SUMO-1 activating enzyme E1 N subunitSUMO-1 activating enzyme subunit 1activator of SUMO1sentrin/SUMO-activating protein AOS1ubiquitin-like 1-activating enzyme E1Aubiquitin-like protein SUMO-1 activating enzymerho GTPase-activating protein 35glucocorticoid receptor DNA-binding factor 1glucocorticoid receptor repression factor 1rho GAP p190A
Modification date2020031320200313
UniProtAcc.

Q9NRY4

Ensembl transtripts involved in fusion geneENST00000270225, ENST00000392776, 
ENST00000413379, ENST00000540850, 
ENST00000598840, 		ENST00000598548, 
ENST00000404338, 
Fusion gene scores* DoF score17 X 10 X 12=204014 X 8 X 8=896
# samples 1914
** MAII scorelog2(19/2040*10)=-3.42449782852791
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(14/896*10)=-2.67807190511264
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SAE1 [Title/Abstract] AND ARHGAP35 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointARHGAP35(47425613)-SAE1(47673075), # samples:2
SAE1(47673180)-ARHGAP35(47491246), # samples:2
Anticipated loss of major functional domain due to fusion event.ARHGAP35-SAE1 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
ARHGAP35-SAE1 seems lost the major protein functional domain in Hgene partner, which is a transcription factor due to the frame-shifted ORF.
ARHGAP35-SAE1 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneSAE1

GO:0016925

protein sumoylation

15660128|20164921

HgeneSAE1

GO:0033235

positive regulation of protein sumoylation

10187858


check buttonFusion gene breakpoints across SAE1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across ARHGAP35 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-BR-8289-01ASAE1chr19

47673180

-ARHGAP35chr19

47491246

+
ChimerDB4STADTCGA-BR-8289-01ASAE1chr19

47673180

+ARHGAP35chr19

47491246

+


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Fusion Gene ORF analysis for SAE1-ARHGAP35

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000270225ENST00000598548SAE1chr19

47673180

+ARHGAP35chr19

47491246

+
5CDS-intronENST00000392776ENST00000598548SAE1chr19

47673180

+ARHGAP35chr19

47491246

+
5CDS-intronENST00000413379ENST00000598548SAE1chr19

47673180

+ARHGAP35chr19

47491246

+
5CDS-intronENST00000540850ENST00000598548SAE1chr19

47673180

+ARHGAP35chr19

47491246

+
5CDS-intronENST00000598840ENST00000598548SAE1chr19

47673180

+ARHGAP35chr19

47491246

+
In-frameENST00000270225ENST00000404338SAE1chr19

47673180

+ARHGAP35chr19

47491246

+
In-frameENST00000392776ENST00000404338SAE1chr19

47673180

+ARHGAP35chr19

47491246

+
In-frameENST00000413379ENST00000404338SAE1chr19

47673180

+ARHGAP35chr19

47491246

+
In-frameENST00000540850ENST00000404338SAE1chr19

47673180

+ARHGAP35chr19

47491246

+
In-frameENST00000598840ENST00000404338SAE1chr19

47673180

+ARHGAP35chr19

47491246

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000413379SAE1chr1947673180+ENST00000404338ARHGAP35chr1947491246+5898835181508496
ENST00000540850SAE1chr1947673180+ENST00000404338ARHGAP35chr1947491246+55795169092084391
ENST00000598840SAE1chr1947673180+ENST00000404338ARHGAP35chr1947491246+564658391256415
ENST00000270225SAE1chr1947673180+ENST00000404338ARHGAP35chr1947491246+5864801291474481
ENST00000392776SAE1chr1947673180+ENST00000404338ARHGAP35chr1947491246+5832769361442468

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000413379ENST00000404338SAE1chr1947673180+ARHGAP35chr1947491246+0.0030228340.9969772
ENST00000540850ENST00000404338SAE1chr1947673180+ARHGAP35chr1947491246+0.0041035620.99589646
ENST00000598840ENST00000404338SAE1chr1947673180+ARHGAP35chr1947491246+0.0033245870.9966754
ENST00000270225ENST00000404338SAE1chr1947673180+ARHGAP35chr1947491246+0.0029643350.9970356
ENST00000392776ENST00000404338SAE1chr1947673180+ARHGAP35chr1947491246+0.0030357650.9969643

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Fusion Genomic Features for SAE1-ARHGAP35


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
SAE1chr1947673180+ARHGAP35chr1947491245+7.21E-101
SAE1chr1947673180+ARHGAP35chr1947491245+7.21E-101

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for SAE1-ARHGAP35


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:47425613/chr19:47673075)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.ARHGAP35

Q9NRY4

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Rho GTPase-activating protein (GAP) (PubMed:19673492, PubMed:28894085). Binds several acidic phospholipids which inhibits the Rho GAP activity to promote the Rac GAP activity (PubMed:19673492). This binding is inhibited by phosphorylation by PRKCA (PubMed:19673492). Involved in cell differentiation as well as cell adhesion and migration, plays an important role in retinal tissue morphogenesis, neural tube fusion, midline fusion of the cerebral hemispheres and mammary gland branching morphogenesis (By similarity). Transduces signals from p21-ras to the nucleus, acting via the ras GTPase-activating protein (GAP) (By similarity). Transduces SRC-dependent signals from cell-surface adhesion molecules, such as laminin, to promote neurite outgrowth. Regulates axon outgrowth, guidance and fasciculation (By similarity). Modulates Rho GTPase-dependent F-actin polymerization, organization and assembly, is involved in polarized cell migration and in the positive regulation of ciliogenesis and cilia elongation (By similarity). During mammary gland development, is required in both the epithelial and stromal compartments for ductal outgrowth (By similarity). Represses transcription of the glucocorticoid receptor by binding to the cis-acting regulatory sequence 5'-GAGAAAAGAAACTGGAGAAACTC-3'; this function is however unclear and would need additional experimental evidences (PubMed:1894621). {ECO:0000250|UniProtKB:P81128, ECO:0000250|UniProtKB:Q91YM2, ECO:0000269|PubMed:1894621, ECO:0000269|PubMed:19673492, ECO:0000269|PubMed:28894085}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneARHGAP35chr19:47673180chr19:47491246ENST00000404338161440_149012751500.0Compositional biasNote=Pro-rich

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneARHGAP35chr19:47673180chr19:47491246ENST00000404338161249_143612751500.0DomainRho-GAP
TgeneARHGAP35chr19:47673180chr19:47491246ENST0000040433816270_32712751500.0DomainNote=FF 1
TgeneARHGAP35chr19:47673180chr19:47491246ENST0000040433816368_42212751500.0DomainNote=FF 2
TgeneARHGAP35chr19:47673180chr19:47491246ENST0000040433816429_48312751500.0DomainNote=FF 3
TgeneARHGAP35chr19:47673180chr19:47491246ENST0000040433816485_55012751500.0DomainNote=FF 4
TgeneARHGAP35chr19:47673180chr19:47491246ENST0000040433816592_76712751500.0DomainpG1 pseudoGTPase
TgeneARHGAP35chr19:47673180chr19:47491246ENST0000040433816783_94712751500.0DomainpG2 pseudoGTPase
TgeneARHGAP35chr19:47673180chr19:47491246ENST0000040433816201_20312751500.0Nucleotide bindingGTP
TgeneARHGAP35chr19:47673180chr19:47491246ENST0000040433816229_23112751500.0Nucleotide bindingGTP
TgeneARHGAP35chr19:47673180chr19:47491246ENST000004043381633_3712751500.0Nucleotide bindingGTP
TgeneARHGAP35chr19:47673180chr19:47491246ENST000004043381695_9712751500.0Nucleotide bindingGTP
TgeneARHGAP35chr19:47673180chr19:47491246ENST00000404338161213_123612751500.0RegionRequired for phospholipid binding and regulation of the substrate preference
TgeneARHGAP35chr19:47673180chr19:47491246ENST00000404338161_26612751500.0RegionHas GTPase activity%2C required for proper localization


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Fusion Gene Sequence for SAE1-ARHGAP35


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>79004_79004_1_SAE1-ARHGAP35_SAE1_chr19_47673180_ENST00000270225_ARHGAP35_chr19_47491246_ENST00000404338_length(transcript)=5864nt_BP=801nt
GTGGCGCGCGGGTCCGGCGGGCGGTTGGCTTGAGCGGGACCGGAGCTGAGGCAGGAAGAGCCGGCGCCATGGTGGAGAAGGAGGAGGCTG
GCGGCGGCATTAGCGAGGAGGAGGCGGCACAGTATGACCGGCAGATCCGCCTGTGGGGACTGGAGGCCCAGAAACGGCTGCGGGCCTCTC
GGGTGCTTCTTGTCGGCTTGAAAGGACTTGGGGCTGAAATTGCCAAGAATCTCATCTTGGCAGGAGTGAAAGGACTGACCATGCTGGATC
ACGAACAGGTAACTCCAGAAGATCCCGGAGCTCAGTTCTTGATTCGTACTGGGTCTGTTGGCCGAAATAGGGCTGAAGCCTCTTTGGAGC
GAGCTCAGAATCTCAACCCCATGGTGGATGTGAAGGTGGACACTGAGGATATAGAGAAGAAACCAGAGTCATTTTTCACTCAATTCGATG
CTGTGTGTCTGACTTGCTGCTCCAGGGATGTCATAGTTAAAGTTGACCAGATCTGTCACAAAAATAGCATCAAGTTCTTTACAGGAGATG
TTTTTGGCTACCATGGATACACATTTGCCAATCTAGGAGAGCATGAGTTTGTAGAGGAGAAAACTAAAGTTGCCAAAGTTAGCCAAGGAG
TAGAAGATGGGCCCGACACCAAGAGAGCAAAACTTGATTCTTCTGAGACAACGATGGTCAAAAAGAAGGTGGTCTTCTGCCCTGTTAAAG
AAGCCCTGGAGGTGGACTGGAGCAGTGAGAAAGCAAAGGCTGCTCTGAAGCGCACGACCTCCGACTACTTTCTCCTTCAAGGACTGAGCA
CGGAAGGCATCTACCGGGTCAGCGGGAACAAGTCTGAGATGGAGAGTCTGCAGAGACAGTTTGATCAAGACCACAACCTGGACCTGGCAG
AGAAAGACTTTACGGTGAATACCGTGGCTGGTGCCATGAAGAGCTTTTTCTCAGAACTGCCTGACCCCCTGGTCCCGTATAACATGCAGA
TCGACTTGGTGGAAGCACACAAAATCAACGACCGGGAGCAGAAGTTGCATGCCCTTAAGGAGGTATTAAAGAAATTTCCAAAGGAAAACC
ACGAAGTCTTCAAGTATGTCATCTCTCACCTAAACAAGGTCAGCCACAACAACAAGGTGAATCTCATGACCAGCGAGAACCTCTCCATCT
GCTTCTGGCCCACCTTGATGAGACCTGATTTCAGCACTATGGACGCCCTCACAGCCACGCGCACCTACCAGACAATCATTGAACTCTTTA
TCCAGCAGTGCCCCTTCTTCTTCTACAATCGGCCCATCACCGAGCCCCCCGGCGCCAGGCCCAGCTCCCCCTCTGCCGTGGCTTCCACCG
TCCCCTTCCTCACTTCCACGCCTGTCACAAGTCAGCCGTCGCCCCCACAGTCGCCTCCACCCACCCCCCAGTCCCCAATGCAGCCACTGC
TTCCCTCCCAGCTTCAAGCCGAACACACGCTGTGAGCCACCAAGACCTGGGGCGACAGGAGAACCGGTCCTCTCTCTGACGGGGTGGCAT
TTGGCCTTGAACAAAACCAAGTCCACTGGGGACAGAGGCAGGGGCAAGTGGCTCTCCCCATTACCTTCTCAAGACCTCAGTGGGAGCACC
AGCCAATGGTACCATCGGCTGGGCTGCCAGGTACCCTGGGCCTGGCGCTGCAGACCTGAGCTGGCTTGGACCCATTTGAGGACTGAACTA
GGCAGGCAATGGCTCCAGTGCCCTCCCTCTGTTCCCTGGACCACCACCCCACGTAGCTGCTCACACCAGCCTCCGGGTGCCTCCCTCTGC
TTGTACAGAGCCCATGGTCGGGACAGTGCCCTGGCCTTTGCCGGGGAGGAGGATGCTCTGAGATTCAGGGTGGGGCTGGCAACCCCTGAA
GAGAACACTTCCTGTTGGTCTGTCTCTTCCCACCTTCCATCTGCACACACCCCCAAGGTAAGGGTACAGCCCGGCTGGCGGCCTCCTTGG
GAACGTGTAGGCCACGGCTCTGCCACCACTAGGTACCTGCTGAGGGCGCTGGCTCTGCAGATCAGAACAACGGAGGATAGCTTTGTGCCT
GGACCCAGAGAGTGTGGGACTCCCCGCTTCATCCCCACCGTCCCACTCCACAGCCTTCCCGAAACATTCCCTGGCAAACAAAGGAACACT
AGGAGAAAAAATGGAAAAACCCTTCCAGTAATTAAAAAGGAAGAAACCACAGAAAGAAAACTACAGACCTCAAGATTCCACTCTGTGCCC
GCCTCTGCCGGGAGGGAGGGAGGCACACAGGTGGAGCTGACCCTCGTCTTTGTGGCAGCAAAACCAGGATGCCTGGAGCTGTGGCCTGAG
GGCCTGCTGGGGTCCCACTCACCCACTTAGGTCTAGTCGCTAGATCCCCCGTTTTCCCAAGAAGAGGGTTCGAGCCCTTGGTGGGGACAG
CTGGGGAGATGGCAGTGCAGGCTGGAACCTGGGCTGCCCCAGAACACAGTCCATTACGATAGAAACACTAATTGAGCATGTGCGTGGGGT
GGGGGTGTGTGTGCACATGTGAGTGTGAGTGTGTGTGGGCGCTTGGTGGGGGGTTGGGGACAGCTGGAAGGTGCCAGGTGCACTTGGGGT
TGGGGTTGGTGTGTTGGGTGTTGAAGTGGAATCGTTTCATCCCAGCCATGGAGGCCACCAGCAGGAGTGTTCATGGGGATGTGGGCGAGG
TGGGGCACTTTGAAGGAATGGCGGTCTGCTGGTGCCCTCGAAGGGGCATCCTTCCTGGTCTTCGCTGACCCAGAGGCGCTGTGCCTGCAT
ATCATCCACCACCACCCTAGCCCAGCCTTCCCACTGCCCCAGGAAAAGCTCTTCTCCTGGCCACCTCTGCCCCCCAGCACCTCAAACTTG
CATGGCTGGGCTGTGGCCTCTGCGGCCAGGAAGCCTGACACTAGGCACCCCCCAGGCGAGAGCTAGTGGGGTGCAGAGGGCCCCATGCCA
GACAGCCCTTGGGGCTCGTTGCACTTTAAGAAATAGGATCTGTGGTGTATTCCAGGGGGCCTGATGGACACCTTTCCCGGGCGTCTGCAG
CTGCCCTGCCCGTGCCCGCCTGCAGTGGTTGGAGACGGGAGTGGCCCTTCGGCTCCCGAGCTCCCTCTGGGGACGGCTGGCTCACTGTCT
CCAGTTCTCAATGGCCAACGAAGGTGCTTGGAAACACCTAACCTTGCAAGTTTTACCGCCTTTTGAGGAACACAAATCGGAGAACAAACC
CAGGGTTCAGGCGTGTTTTCTGTGAATGTTGGATGATGAATTTTTGTCTCTTCTGGTGGAGCTGTGCCTGGCCCTGTAGGCCCAGGGTTG
GCTGGAAGGTGACATCTGTGTTTCGTTTTAGCTGAGGTTGGCAGAAACGTTCCCAAACTCCCCCAGCCCTGGACCCCAGCAGATGAGGAA
ACGGCCCCATTTACTGACCCCGCCCCCTTTTCGAGGTTATGCTCACCTGGTCAGCTCCTCACGTAATTGGGGGTGGAGGGAAAGCATGGT
GGTGCCCTGGGCCGTCCCTGTGTGAACGCAGGCAAAAGCAGCCCAGTCCCCCTCACTGCTTGAGCTAACACTGCCACCTCTTTTGTGTGA
GCACAAAAGCCACGTCCCAAGCCACCTGGCCCGATTCCACAGATGTATGTGCGGCCAGTGACTTCCCCAGGAGTGTGGAGGGGGTGGTGA
GGAGGAGCACCTGGGCTCTCTACCCCTCTCCTCACAGAAGTACCTGAAACTAGGTCTGGGGCACTCCCAATGCAGCGCCTTGTCAGCCAA
GGTGGGCAGGCAGGGACTGTGGCAGCTTATGTCCAAAGGGAGCCCCCATGCACAGGAAGCCACAGGGTTCCTCTTGTTTCCCCCGCTAAC
TTCAGCCTCTCATCTGCTGCTCCGGGCTGAGGGACTAGAGGACATCTCGGTCGTTTGAGGGGCATGGCCAGTCGTGGCAGGCCGGCCTTC
AGCGTCCGGTCAGGGAAGCGTGCAGCCCAAATGGGCACTTGCATGGGAGCCACAGAGGAGCGTCCCTGGGGATTGTTGGGACCATGCTGC
CCCCACTCCCGCTTTTGTTGGGGCTCTAAGTTCTGGAAGGTGTGTGCACAGAGGGTGCTCATGGGACTCGCATGCAGCTCTCAGCACTGG
GTGGGAGGGCGTTGGCTTGTCCAGAATGGGGACGTGGGGCAGCCACCCCTGCCCAGCGAGAGCGCAGACACCGTGTGAGGGGACAGCAGC
CCTTGGTGCAAAGCCAGAGACTGATCCTGGCTCTGACGGCTGAAGAGGGAAGACCCAAGGCTGGGTGGCGTGGCTCGTGAATCCACTTAG
AATTCTTGGCTTGTGTCGCATACTGGGTGTCACGGCACACATTTACTCTGCATTGTCCCCGTCTTTCCCATCGCCTAGCGTTTGGGGAGG
AACAGGGAGAGAGCTTCGGGGCGTCTGTCTCCGTGCTCTCCTGCCTCCACCGCCTTGGTTTTGCTTCCTGCTGGAGGCAGGGCACCTGCT
GCGACCCAGATTCTTCTGCAGGATGTGTCTGTCTTTGTCACGGTGGACAGAGGGTGACATCATAGGAGCAGCTCGCTGGCCAGAAGGGGA
TGGGGGCATCCCTGTGCCTCACTCAGCTCCTGCTGCTCTTAGGGAAAGGAGGCCTGGGTCAAGCCAGCATCCCCTTGGTAAAGACCCCCG
CAGGCCACCAGGCATTCTGGACACGCACACACACACACACACACACACACACACACAAAACTTCACAGCAGGCCAGCTGCAGTGACTTGT
CATCAAGAGTCACCTCAGCTGCGCCCCCCTCCCATCCTTTCCTATGAGAAGCCACTGCTTTGGGGGCGCCGGCTAGAAAAAGTAGGGTGC
GGTGGCCAGGAGGGCCCCTGCCGCGCGGGGGGCTGGGTCTGGTTGAGTCGCTGCTTTCCCGAGGGCAGCGCAGGGATCCGGGGAAGCTGC
GGCAGGGAGCGGGCGCCGGCTTCGTGGCTCTGAGGTGTAACGGGGGTGGGCTCCCTCCCTCGGAGGACATCGTCTGTGTCCAGGTCAGAA
AGTGGCCCAGGAAGGGGGCAGTTTCTGTCGCGGGTCCGGTGGGGGCGCGGCCGCGGTGCGGTCGGTGCAGCGTGGCCAATGCGCGGCGCG
CGCGGGGGACAGAGCAGGAGGCGGTCTGTCACCTCGGCCACTGCTGACCTGGGCTGGCCTCCCCCAGCCCTCCCGTGGCGGAGCCGGCAG
CGATGCTACAGGCCTAAGTTATTGTTTGCATAAAAAGAATCATGTTCCCTGTGTACATTTAAGAAAAAAACAAAAAAACGGAAATGTCAG
AATTGTATGGAAATAAAACTTGTTTGAAAATTTGGAATAGTGCTGCTGCCAGCTTATTTTTCTGGTACTTGTATTTTCACATGTTAAATG
ATCTTTATATATGTTGAATTAACAAATATTTTGAGTTTCTGAGAAAAAACAAAACATATTAATGGTATTGAAATGTGTTAGTAGTCTGGC
TGTGTGCCCAAAATTCTGTTTCGCAGCAAAAGTGAAGACCTGTATGTAAAGAAAGTATAACAATTATTTCTTTGTATTTTAGGGGCTTTA
ACCGGAACATCGTCTAGCTGGTGTTAGGAATGTTTGCTTAATTTCCAGACTTTTTTTTAAAAACACATCGTGGGTTTTTTGAGGCTCCAA
CCTGATTAGTGCATGGTCAGCCCTCAATGAAGGCTGAGGCATCTCTGACTGAGGTGTTTTTGTTTGGTTTTGTTTTTTAAAATCATGTAT
TTGCTACAAAGTATTGTACTTGTCTCAATGGGAATGGTGTAAAAAACAAAAGGCCTTATGTGATCTGTATCATAGTTAATAAATGAATCT

>79004_79004_1_SAE1-ARHGAP35_SAE1_chr19_47673180_ENST00000270225_ARHGAP35_chr19_47491246_ENST00000404338_length(amino acids)=481AA_BP=257
MSGTGAEAGRAGAMVEKEEAGGGISEEEAAQYDRQIRLWGLEAQKRLRASRVLLVGLKGLGAEIAKNLILAGVKGLTMLDHEQVTPEDPG
AQFLIRTGSVGRNRAEASLERAQNLNPMVDVKVDTEDIEKKPESFFTQFDAVCLTCCSRDVIVKVDQICHKNSIKFFTGDVFGYHGYTFA
NLGEHEFVEEKTKVAKVSQGVEDGPDTKRAKLDSSETTMVKKKVVFCPVKEALEVDWSSEKAKAALKRTTSDYFLLQGLSTEGIYRVSGN
KSEMESLQRQFDQDHNLDLAEKDFTVNTVAGAMKSFFSELPDPLVPYNMQIDLVEAHKINDREQKLHALKEVLKKFPKENHEVFKYVISH
LNKVSHNNKVNLMTSENLSICFWPTLMRPDFSTMDALTATRTYQTIIELFIQQCPFFFYNRPITEPPGARPSSPSAVASTVPFLTSTPVT

--------------------------------------------------------------
>79004_79004_2_SAE1-ARHGAP35_SAE1_chr19_47673180_ENST00000392776_ARHGAP35_chr19_47491246_ENST00000404338_length(transcript)=5832nt_BP=769nt
AGCGGGACCGGAGCTGAGGCAGGAAGAGCCGGCGCCATGGTGGAGAAGGAGGAGGCTGGCGGCGGCATTAGCGAGGAGGAGGCGGCACAG
TATGACCGGCAGATCCGCCTGTGGGGACTGGAGGCCCAGAAACGGCTGCGGGCCTCTCGGGTGCTTCTTGTCGGCTTGAAAGGACTTGGG
GCTGAAATTGCCAAGAATCTCATCTTGGCAGGAGTGAAAGGACTGACCATGCTGGATCACGAACAGGTAACTCCAGAAGATCCCGGAGCT
CAGTTCTTGATTCGTACTGGGTCTGTTGGCCGAAATAGGGCTGAAGCCTCTTTGGAGCGAGCTCAGAATCTCAACCCCATGGTGGATGTG
AAGGTGGACACTGAGGATATAGAGAAGAAACCAGAGTCATTTTTCACTCAATTCGATGCTGTGTGTCTGACTTGCTGCTCCAGGGATGTC
ATAGTTAAAGTTGACCAGATCTGTCACAAAAATAGCATCAAGTTCTTTACAGGAGATGTTTTTGGCTACCATGGATACACATTTGCCAAT
CTAGGAGAGCATGAGTTTGTAGAGGAGAAAACTAAAGTTGCCAAAGTTAGCCAAGGAGTAGAAGATGGGCCCGACACCAAGAGAGCAAAA
CTTGATTCTTCTGAGACAACGATGGTCAAAAAGAAGGTGGTCTTCTGCCCTGTTAAAGAAGCCCTGGAGGTGGACTGGAGCAGTGAGAAA
GCAAAGGCTGCTCTGAAGCGCACGACCTCCGACTACTTTCTCCTTCAAGGACTGAGCACGGAAGGCATCTACCGGGTCAGCGGGAACAAG
TCTGAGATGGAGAGTCTGCAGAGACAGTTTGATCAAGACCACAACCTGGACCTGGCAGAGAAAGACTTTACGGTGAATACCGTGGCTGGT
GCCATGAAGAGCTTTTTCTCAGAACTGCCTGACCCCCTGGTCCCGTATAACATGCAGATCGACTTGGTGGAAGCACACAAAATCAACGAC
CGGGAGCAGAAGTTGCATGCCCTTAAGGAGGTATTAAAGAAATTTCCAAAGGAAAACCACGAAGTCTTCAAGTATGTCATCTCTCACCTA
AACAAGGTCAGCCACAACAACAAGGTGAATCTCATGACCAGCGAGAACCTCTCCATCTGCTTCTGGCCCACCTTGATGAGACCTGATTTC
AGCACTATGGACGCCCTCACAGCCACGCGCACCTACCAGACAATCATTGAACTCTTTATCCAGCAGTGCCCCTTCTTCTTCTACAATCGG
CCCATCACCGAGCCCCCCGGCGCCAGGCCCAGCTCCCCCTCTGCCGTGGCTTCCACCGTCCCCTTCCTCACTTCCACGCCTGTCACAAGT
CAGCCGTCGCCCCCACAGTCGCCTCCACCCACCCCCCAGTCCCCAATGCAGCCACTGCTTCCCTCCCAGCTTCAAGCCGAACACACGCTG
TGAGCCACCAAGACCTGGGGCGACAGGAGAACCGGTCCTCTCTCTGACGGGGTGGCATTTGGCCTTGAACAAAACCAAGTCCACTGGGGA
CAGAGGCAGGGGCAAGTGGCTCTCCCCATTACCTTCTCAAGACCTCAGTGGGAGCACCAGCCAATGGTACCATCGGCTGGGCTGCCAGGT
ACCCTGGGCCTGGCGCTGCAGACCTGAGCTGGCTTGGACCCATTTGAGGACTGAACTAGGCAGGCAATGGCTCCAGTGCCCTCCCTCTGT
TCCCTGGACCACCACCCCACGTAGCTGCTCACACCAGCCTCCGGGTGCCTCCCTCTGCTTGTACAGAGCCCATGGTCGGGACAGTGCCCT
GGCCTTTGCCGGGGAGGAGGATGCTCTGAGATTCAGGGTGGGGCTGGCAACCCCTGAAGAGAACACTTCCTGTTGGTCTGTCTCTTCCCA
CCTTCCATCTGCACACACCCCCAAGGTAAGGGTACAGCCCGGCTGGCGGCCTCCTTGGGAACGTGTAGGCCACGGCTCTGCCACCACTAG
GTACCTGCTGAGGGCGCTGGCTCTGCAGATCAGAACAACGGAGGATAGCTTTGTGCCTGGACCCAGAGAGTGTGGGACTCCCCGCTTCAT
CCCCACCGTCCCACTCCACAGCCTTCCCGAAACATTCCCTGGCAAACAAAGGAACACTAGGAGAAAAAATGGAAAAACCCTTCCAGTAAT
TAAAAAGGAAGAAACCACAGAAAGAAAACTACAGACCTCAAGATTCCACTCTGTGCCCGCCTCTGCCGGGAGGGAGGGAGGCACACAGGT
GGAGCTGACCCTCGTCTTTGTGGCAGCAAAACCAGGATGCCTGGAGCTGTGGCCTGAGGGCCTGCTGGGGTCCCACTCACCCACTTAGGT
CTAGTCGCTAGATCCCCCGTTTTCCCAAGAAGAGGGTTCGAGCCCTTGGTGGGGACAGCTGGGGAGATGGCAGTGCAGGCTGGAACCTGG
GCTGCCCCAGAACACAGTCCATTACGATAGAAACACTAATTGAGCATGTGCGTGGGGTGGGGGTGTGTGTGCACATGTGAGTGTGAGTGT
GTGTGGGCGCTTGGTGGGGGGTTGGGGACAGCTGGAAGGTGCCAGGTGCACTTGGGGTTGGGGTTGGTGTGTTGGGTGTTGAAGTGGAAT
CGTTTCATCCCAGCCATGGAGGCCACCAGCAGGAGTGTTCATGGGGATGTGGGCGAGGTGGGGCACTTTGAAGGAATGGCGGTCTGCTGG
TGCCCTCGAAGGGGCATCCTTCCTGGTCTTCGCTGACCCAGAGGCGCTGTGCCTGCATATCATCCACCACCACCCTAGCCCAGCCTTCCC
ACTGCCCCAGGAAAAGCTCTTCTCCTGGCCACCTCTGCCCCCCAGCACCTCAAACTTGCATGGCTGGGCTGTGGCCTCTGCGGCCAGGAA
GCCTGACACTAGGCACCCCCCAGGCGAGAGCTAGTGGGGTGCAGAGGGCCCCATGCCAGACAGCCCTTGGGGCTCGTTGCACTTTAAGAA
ATAGGATCTGTGGTGTATTCCAGGGGGCCTGATGGACACCTTTCCCGGGCGTCTGCAGCTGCCCTGCCCGTGCCCGCCTGCAGTGGTTGG
AGACGGGAGTGGCCCTTCGGCTCCCGAGCTCCCTCTGGGGACGGCTGGCTCACTGTCTCCAGTTCTCAATGGCCAACGAAGGTGCTTGGA
AACACCTAACCTTGCAAGTTTTACCGCCTTTTGAGGAACACAAATCGGAGAACAAACCCAGGGTTCAGGCGTGTTTTCTGTGAATGTTGG
ATGATGAATTTTTGTCTCTTCTGGTGGAGCTGTGCCTGGCCCTGTAGGCCCAGGGTTGGCTGGAAGGTGACATCTGTGTTTCGTTTTAGC
TGAGGTTGGCAGAAACGTTCCCAAACTCCCCCAGCCCTGGACCCCAGCAGATGAGGAAACGGCCCCATTTACTGACCCCGCCCCCTTTTC
GAGGTTATGCTCACCTGGTCAGCTCCTCACGTAATTGGGGGTGGAGGGAAAGCATGGTGGTGCCCTGGGCCGTCCCTGTGTGAACGCAGG
CAAAAGCAGCCCAGTCCCCCTCACTGCTTGAGCTAACACTGCCACCTCTTTTGTGTGAGCACAAAAGCCACGTCCCAAGCCACCTGGCCC
GATTCCACAGATGTATGTGCGGCCAGTGACTTCCCCAGGAGTGTGGAGGGGGTGGTGAGGAGGAGCACCTGGGCTCTCTACCCCTCTCCT
CACAGAAGTACCTGAAACTAGGTCTGGGGCACTCCCAATGCAGCGCCTTGTCAGCCAAGGTGGGCAGGCAGGGACTGTGGCAGCTTATGT
CCAAAGGGAGCCCCCATGCACAGGAAGCCACAGGGTTCCTCTTGTTTCCCCCGCTAACTTCAGCCTCTCATCTGCTGCTCCGGGCTGAGG
GACTAGAGGACATCTCGGTCGTTTGAGGGGCATGGCCAGTCGTGGCAGGCCGGCCTTCAGCGTCCGGTCAGGGAAGCGTGCAGCCCAAAT
GGGCACTTGCATGGGAGCCACAGAGGAGCGTCCCTGGGGATTGTTGGGACCATGCTGCCCCCACTCCCGCTTTTGTTGGGGCTCTAAGTT
CTGGAAGGTGTGTGCACAGAGGGTGCTCATGGGACTCGCATGCAGCTCTCAGCACTGGGTGGGAGGGCGTTGGCTTGTCCAGAATGGGGA
CGTGGGGCAGCCACCCCTGCCCAGCGAGAGCGCAGACACCGTGTGAGGGGACAGCAGCCCTTGGTGCAAAGCCAGAGACTGATCCTGGCT
CTGACGGCTGAAGAGGGAAGACCCAAGGCTGGGTGGCGTGGCTCGTGAATCCACTTAGAATTCTTGGCTTGTGTCGCATACTGGGTGTCA
CGGCACACATTTACTCTGCATTGTCCCCGTCTTTCCCATCGCCTAGCGTTTGGGGAGGAACAGGGAGAGAGCTTCGGGGCGTCTGTCTCC
GTGCTCTCCTGCCTCCACCGCCTTGGTTTTGCTTCCTGCTGGAGGCAGGGCACCTGCTGCGACCCAGATTCTTCTGCAGGATGTGTCTGT
CTTTGTCACGGTGGACAGAGGGTGACATCATAGGAGCAGCTCGCTGGCCAGAAGGGGATGGGGGCATCCCTGTGCCTCACTCAGCTCCTG
CTGCTCTTAGGGAAAGGAGGCCTGGGTCAAGCCAGCATCCCCTTGGTAAAGACCCCCGCAGGCCACCAGGCATTCTGGACACGCACACAC
ACACACACACACACACACACACACAAAACTTCACAGCAGGCCAGCTGCAGTGACTTGTCATCAAGAGTCACCTCAGCTGCGCCCCCCTCC
CATCCTTTCCTATGAGAAGCCACTGCTTTGGGGGCGCCGGCTAGAAAAAGTAGGGTGCGGTGGCCAGGAGGGCCCCTGCCGCGCGGGGGG
CTGGGTCTGGTTGAGTCGCTGCTTTCCCGAGGGCAGCGCAGGGATCCGGGGAAGCTGCGGCAGGGAGCGGGCGCCGGCTTCGTGGCTCTG
AGGTGTAACGGGGGTGGGCTCCCTCCCTCGGAGGACATCGTCTGTGTCCAGGTCAGAAAGTGGCCCAGGAAGGGGGCAGTTTCTGTCGCG
GGTCCGGTGGGGGCGCGGCCGCGGTGCGGTCGGTGCAGCGTGGCCAATGCGCGGCGCGCGCGGGGGACAGAGCAGGAGGCGGTCTGTCAC
CTCGGCCACTGCTGACCTGGGCTGGCCTCCCCCAGCCCTCCCGTGGCGGAGCCGGCAGCGATGCTACAGGCCTAAGTTATTGTTTGCATA
AAAAGAATCATGTTCCCTGTGTACATTTAAGAAAAAAACAAAAAAACGGAAATGTCAGAATTGTATGGAAATAAAACTTGTTTGAAAATT
TGGAATAGTGCTGCTGCCAGCTTATTTTTCTGGTACTTGTATTTTCACATGTTAAATGATCTTTATATATGTTGAATTAACAAATATTTT
GAGTTTCTGAGAAAAAACAAAACATATTAATGGTATTGAAATGTGTTAGTAGTCTGGCTGTGTGCCCAAAATTCTGTTTCGCAGCAAAAG
TGAAGACCTGTATGTAAAGAAAGTATAACAATTATTTCTTTGTATTTTAGGGGCTTTAACCGGAACATCGTCTAGCTGGTGTTAGGAATG
TTTGCTTAATTTCCAGACTTTTTTTTAAAAACACATCGTGGGTTTTTTGAGGCTCCAACCTGATTAGTGCATGGTCAGCCCTCAATGAAG
GCTGAGGCATCTCTGACTGAGGTGTTTTTGTTTGGTTTTGTTTTTTAAAATCATGTATTTGCTACAAAGTATTGTACTTGTCTCAATGGG

>79004_79004_2_SAE1-ARHGAP35_SAE1_chr19_47673180_ENST00000392776_ARHGAP35_chr19_47491246_ENST00000404338_length(amino acids)=468AA_BP=244
MVEKEEAGGGISEEEAAQYDRQIRLWGLEAQKRLRASRVLLVGLKGLGAEIAKNLILAGVKGLTMLDHEQVTPEDPGAQFLIRTGSVGRN
RAEASLERAQNLNPMVDVKVDTEDIEKKPESFFTQFDAVCLTCCSRDVIVKVDQICHKNSIKFFTGDVFGYHGYTFANLGEHEFVEEKTK
VAKVSQGVEDGPDTKRAKLDSSETTMVKKKVVFCPVKEALEVDWSSEKAKAALKRTTSDYFLLQGLSTEGIYRVSGNKSEMESLQRQFDQ
DHNLDLAEKDFTVNTVAGAMKSFFSELPDPLVPYNMQIDLVEAHKINDREQKLHALKEVLKKFPKENHEVFKYVISHLNKVSHNNKVNLM
TSENLSICFWPTLMRPDFSTMDALTATRTYQTIIELFIQQCPFFFYNRPITEPPGARPSSPSAVASTVPFLTSTPVTSQPSPPQSPPPTP

--------------------------------------------------------------
>79004_79004_3_SAE1-ARHGAP35_SAE1_chr19_47673180_ENST00000413379_ARHGAP35_chr19_47491246_ENST00000404338_length(transcript)=5898nt_BP=835nt
AGAAGCACTCCGGGCGTGCTGCCGGCGGCGGTAGGTGGCGCGCGGGTCCGGCGGGCGGTTGGCTTGAGCGGGACCGGAGCTGAGGCAGGA
AGAGCCGGCGCCATGGTGGAGAAGGAGGAGGCTGGCGGCGGCATTAGCGAGGAGGAGGCGGCACAGTATGACCGGCAGATCCGCCTGTGG
GGACTGGAGGCCCAGAAACGGCTGCGGGCCTCTCGGGTGCTTCTTGTCGGCTTGAAAGGACTTGGGGCTGAAATTGCCAAGAATCTCATC
TTGGCAGGAGTGAAAGGACTGACCATGCTGGATCACGAACAGGTAACTCCAGAAGATCCCGGAGCTCAGTTCTTGATTCGTACTGGGTCT
GTTGGCCGAAATAGGGCTGAAGCCTCTTTGGAGCGAGCTCAGAATCTCAACCCCATGGTGGATGTGAAGGTGGACACTGAGGATATAGAG
AAGAAACCAGAGTCATTTTTCACTCAATTCGATGCTGTGTGTCTGACTTGCTGCTCCAGGGATGTCATAGTTAAAGTTGACCAGATCTGT
CACAAAAATAGCATCAAGTTCTTTACAGGAGATGTTTTTGGCTACCATGGATACACATTTGCCAATCTAGGAGAGCATGAGTTTGTAGAG
GAGAAAACTAAAGTTGCCAAAGTTAGCCAAGGAGTAGAAGATGGGCCCGACACCAAGAGAGCAAAACTTGATTCTTCTGAGACAACGATG
GTCAAAAAGAAGGTGGTCTTCTGCCCTGTTAAAGAAGCCCTGGAGGTGGACTGGAGCAGTGAGAAAGCAAAGGCTGCTCTGAAGCGCACG
ACCTCCGACTACTTTCTCCTTCAAGGACTGAGCACGGAAGGCATCTACCGGGTCAGCGGGAACAAGTCTGAGATGGAGAGTCTGCAGAGA
CAGTTTGATCAAGACCACAACCTGGACCTGGCAGAGAAAGACTTTACGGTGAATACCGTGGCTGGTGCCATGAAGAGCTTTTTCTCAGAA
CTGCCTGACCCCCTGGTCCCGTATAACATGCAGATCGACTTGGTGGAAGCACACAAAATCAACGACCGGGAGCAGAAGTTGCATGCCCTT
AAGGAGGTATTAAAGAAATTTCCAAAGGAAAACCACGAAGTCTTCAAGTATGTCATCTCTCACCTAAACAAGGTCAGCCACAACAACAAG
GTGAATCTCATGACCAGCGAGAACCTCTCCATCTGCTTCTGGCCCACCTTGATGAGACCTGATTTCAGCACTATGGACGCCCTCACAGCC
ACGCGCACCTACCAGACAATCATTGAACTCTTTATCCAGCAGTGCCCCTTCTTCTTCTACAATCGGCCCATCACCGAGCCCCCCGGCGCC
AGGCCCAGCTCCCCCTCTGCCGTGGCTTCCACCGTCCCCTTCCTCACTTCCACGCCTGTCACAAGTCAGCCGTCGCCCCCACAGTCGCCT
CCACCCACCCCCCAGTCCCCAATGCAGCCACTGCTTCCCTCCCAGCTTCAAGCCGAACACACGCTGTGAGCCACCAAGACCTGGGGCGAC
AGGAGAACCGGTCCTCTCTCTGACGGGGTGGCATTTGGCCTTGAACAAAACCAAGTCCACTGGGGACAGAGGCAGGGGCAAGTGGCTCTC
CCCATTACCTTCTCAAGACCTCAGTGGGAGCACCAGCCAATGGTACCATCGGCTGGGCTGCCAGGTACCCTGGGCCTGGCGCTGCAGACC
TGAGCTGGCTTGGACCCATTTGAGGACTGAACTAGGCAGGCAATGGCTCCAGTGCCCTCCCTCTGTTCCCTGGACCACCACCCCACGTAG
CTGCTCACACCAGCCTCCGGGTGCCTCCCTCTGCTTGTACAGAGCCCATGGTCGGGACAGTGCCCTGGCCTTTGCCGGGGAGGAGGATGC
TCTGAGATTCAGGGTGGGGCTGGCAACCCCTGAAGAGAACACTTCCTGTTGGTCTGTCTCTTCCCACCTTCCATCTGCACACACCCCCAA
GGTAAGGGTACAGCCCGGCTGGCGGCCTCCTTGGGAACGTGTAGGCCACGGCTCTGCCACCACTAGGTACCTGCTGAGGGCGCTGGCTCT
GCAGATCAGAACAACGGAGGATAGCTTTGTGCCTGGACCCAGAGAGTGTGGGACTCCCCGCTTCATCCCCACCGTCCCACTCCACAGCCT
TCCCGAAACATTCCCTGGCAAACAAAGGAACACTAGGAGAAAAAATGGAAAAACCCTTCCAGTAATTAAAAAGGAAGAAACCACAGAAAG
AAAACTACAGACCTCAAGATTCCACTCTGTGCCCGCCTCTGCCGGGAGGGAGGGAGGCACACAGGTGGAGCTGACCCTCGTCTTTGTGGC
AGCAAAACCAGGATGCCTGGAGCTGTGGCCTGAGGGCCTGCTGGGGTCCCACTCACCCACTTAGGTCTAGTCGCTAGATCCCCCGTTTTC
CCAAGAAGAGGGTTCGAGCCCTTGGTGGGGACAGCTGGGGAGATGGCAGTGCAGGCTGGAACCTGGGCTGCCCCAGAACACAGTCCATTA
CGATAGAAACACTAATTGAGCATGTGCGTGGGGTGGGGGTGTGTGTGCACATGTGAGTGTGAGTGTGTGTGGGCGCTTGGTGGGGGGTTG
GGGACAGCTGGAAGGTGCCAGGTGCACTTGGGGTTGGGGTTGGTGTGTTGGGTGTTGAAGTGGAATCGTTTCATCCCAGCCATGGAGGCC
ACCAGCAGGAGTGTTCATGGGGATGTGGGCGAGGTGGGGCACTTTGAAGGAATGGCGGTCTGCTGGTGCCCTCGAAGGGGCATCCTTCCT
GGTCTTCGCTGACCCAGAGGCGCTGTGCCTGCATATCATCCACCACCACCCTAGCCCAGCCTTCCCACTGCCCCAGGAAAAGCTCTTCTC
CTGGCCACCTCTGCCCCCCAGCACCTCAAACTTGCATGGCTGGGCTGTGGCCTCTGCGGCCAGGAAGCCTGACACTAGGCACCCCCCAGG
CGAGAGCTAGTGGGGTGCAGAGGGCCCCATGCCAGACAGCCCTTGGGGCTCGTTGCACTTTAAGAAATAGGATCTGTGGTGTATTCCAGG
GGGCCTGATGGACACCTTTCCCGGGCGTCTGCAGCTGCCCTGCCCGTGCCCGCCTGCAGTGGTTGGAGACGGGAGTGGCCCTTCGGCTCC
CGAGCTCCCTCTGGGGACGGCTGGCTCACTGTCTCCAGTTCTCAATGGCCAACGAAGGTGCTTGGAAACACCTAACCTTGCAAGTTTTAC
CGCCTTTTGAGGAACACAAATCGGAGAACAAACCCAGGGTTCAGGCGTGTTTTCTGTGAATGTTGGATGATGAATTTTTGTCTCTTCTGG
TGGAGCTGTGCCTGGCCCTGTAGGCCCAGGGTTGGCTGGAAGGTGACATCTGTGTTTCGTTTTAGCTGAGGTTGGCAGAAACGTTCCCAA
ACTCCCCCAGCCCTGGACCCCAGCAGATGAGGAAACGGCCCCATTTACTGACCCCGCCCCCTTTTCGAGGTTATGCTCACCTGGTCAGCT
CCTCACGTAATTGGGGGTGGAGGGAAAGCATGGTGGTGCCCTGGGCCGTCCCTGTGTGAACGCAGGCAAAAGCAGCCCAGTCCCCCTCAC
TGCTTGAGCTAACACTGCCACCTCTTTTGTGTGAGCACAAAAGCCACGTCCCAAGCCACCTGGCCCGATTCCACAGATGTATGTGCGGCC
AGTGACTTCCCCAGGAGTGTGGAGGGGGTGGTGAGGAGGAGCACCTGGGCTCTCTACCCCTCTCCTCACAGAAGTACCTGAAACTAGGTC
TGGGGCACTCCCAATGCAGCGCCTTGTCAGCCAAGGTGGGCAGGCAGGGACTGTGGCAGCTTATGTCCAAAGGGAGCCCCCATGCACAGG
AAGCCACAGGGTTCCTCTTGTTTCCCCCGCTAACTTCAGCCTCTCATCTGCTGCTCCGGGCTGAGGGACTAGAGGACATCTCGGTCGTTT
GAGGGGCATGGCCAGTCGTGGCAGGCCGGCCTTCAGCGTCCGGTCAGGGAAGCGTGCAGCCCAAATGGGCACTTGCATGGGAGCCACAGA
GGAGCGTCCCTGGGGATTGTTGGGACCATGCTGCCCCCACTCCCGCTTTTGTTGGGGCTCTAAGTTCTGGAAGGTGTGTGCACAGAGGGT
GCTCATGGGACTCGCATGCAGCTCTCAGCACTGGGTGGGAGGGCGTTGGCTTGTCCAGAATGGGGACGTGGGGCAGCCACCCCTGCCCAG
CGAGAGCGCAGACACCGTGTGAGGGGACAGCAGCCCTTGGTGCAAAGCCAGAGACTGATCCTGGCTCTGACGGCTGAAGAGGGAAGACCC
AAGGCTGGGTGGCGTGGCTCGTGAATCCACTTAGAATTCTTGGCTTGTGTCGCATACTGGGTGTCACGGCACACATTTACTCTGCATTGT
CCCCGTCTTTCCCATCGCCTAGCGTTTGGGGAGGAACAGGGAGAGAGCTTCGGGGCGTCTGTCTCCGTGCTCTCCTGCCTCCACCGCCTT
GGTTTTGCTTCCTGCTGGAGGCAGGGCACCTGCTGCGACCCAGATTCTTCTGCAGGATGTGTCTGTCTTTGTCACGGTGGACAGAGGGTG
ACATCATAGGAGCAGCTCGCTGGCCAGAAGGGGATGGGGGCATCCCTGTGCCTCACTCAGCTCCTGCTGCTCTTAGGGAAAGGAGGCCTG
GGTCAAGCCAGCATCCCCTTGGTAAAGACCCCCGCAGGCCACCAGGCATTCTGGACACGCACACACACACACACACACACACACACACAC
AAAACTTCACAGCAGGCCAGCTGCAGTGACTTGTCATCAAGAGTCACCTCAGCTGCGCCCCCCTCCCATCCTTTCCTATGAGAAGCCACT
GCTTTGGGGGCGCCGGCTAGAAAAAGTAGGGTGCGGTGGCCAGGAGGGCCCCTGCCGCGCGGGGGGCTGGGTCTGGTTGAGTCGCTGCTT
TCCCGAGGGCAGCGCAGGGATCCGGGGAAGCTGCGGCAGGGAGCGGGCGCCGGCTTCGTGGCTCTGAGGTGTAACGGGGGTGGGCTCCCT
CCCTCGGAGGACATCGTCTGTGTCCAGGTCAGAAAGTGGCCCAGGAAGGGGGCAGTTTCTGTCGCGGGTCCGGTGGGGGCGCGGCCGCGG
TGCGGTCGGTGCAGCGTGGCCAATGCGCGGCGCGCGCGGGGGACAGAGCAGGAGGCGGTCTGTCACCTCGGCCACTGCTGACCTGGGCTG
GCCTCCCCCAGCCCTCCCGTGGCGGAGCCGGCAGCGATGCTACAGGCCTAAGTTATTGTTTGCATAAAAAGAATCATGTTCCCTGTGTAC
ATTTAAGAAAAAAACAAAAAAACGGAAATGTCAGAATTGTATGGAAATAAAACTTGTTTGAAAATTTGGAATAGTGCTGCTGCCAGCTTA
TTTTTCTGGTACTTGTATTTTCACATGTTAAATGATCTTTATATATGTTGAATTAACAAATATTTTGAGTTTCTGAGAAAAAACAAAACA
TATTAATGGTATTGAAATGTGTTAGTAGTCTGGCTGTGTGCCCAAAATTCTGTTTCGCAGCAAAAGTGAAGACCTGTATGTAAAGAAAGT
ATAACAATTATTTCTTTGTATTTTAGGGGCTTTAACCGGAACATCGTCTAGCTGGTGTTAGGAATGTTTGCTTAATTTCCAGACTTTTTT
TTAAAAACACATCGTGGGTTTTTTGAGGCTCCAACCTGATTAGTGCATGGTCAGCCCTCAATGAAGGCTGAGGCATCTCTGACTGAGGTG
TTTTTGTTTGGTTTTGTTTTTTAAAATCATGTATTTGCTACAAAGTATTGTACTTGTCTCAATGGGAATGGTGTAAAAAACAAAAGGCCT

>79004_79004_3_SAE1-ARHGAP35_SAE1_chr19_47673180_ENST00000413379_ARHGAP35_chr19_47491246_ENST00000404338_length(amino acids)=496AA_BP=272
MPAAVGGARVRRAVGLSGTGAEAGRAGAMVEKEEAGGGISEEEAAQYDRQIRLWGLEAQKRLRASRVLLVGLKGLGAEIAKNLILAGVKG
LTMLDHEQVTPEDPGAQFLIRTGSVGRNRAEASLERAQNLNPMVDVKVDTEDIEKKPESFFTQFDAVCLTCCSRDVIVKVDQICHKNSIK
FFTGDVFGYHGYTFANLGEHEFVEEKTKVAKVSQGVEDGPDTKRAKLDSSETTMVKKKVVFCPVKEALEVDWSSEKAKAALKRTTSDYFL
LQGLSTEGIYRVSGNKSEMESLQRQFDQDHNLDLAEKDFTVNTVAGAMKSFFSELPDPLVPYNMQIDLVEAHKINDREQKLHALKEVLKK
FPKENHEVFKYVISHLNKVSHNNKVNLMTSENLSICFWPTLMRPDFSTMDALTATRTYQTIIELFIQQCPFFFYNRPITEPPGARPSSPS

--------------------------------------------------------------
>79004_79004_4_SAE1-ARHGAP35_SAE1_chr19_47673180_ENST00000540850_ARHGAP35_chr19_47491246_ENST00000404338_length(transcript)=5579nt_BP=516nt
ACTCCGGGCGTGCTGCCGGCGGCGGCTGCGGGCCTCTCGGGTGCTTCTTGTCGGCTTGAAAGGACTTGGGGCTGAAATTGCCAAGAATCT
CATCTTGGCAGGAGTGAAAGGACTGACCATGCTGGATCACGAACAGGTAACTCCAGAAGATCCCGGAGCTCAGTTCTTGATTCGTACTGG
GTCTGTTGGCCGAAATAGGGCTGAAGCCTCTTTGGAGCGAGCTCAGAATCTCAACCCCATGGTGGATGTGAAGGTGGACACTGAGGATAT
AGAGAAGAAACCAGAGTCATTTTTCACTCAATTCGATGCTGGAGAAAACTAAAGTTGCCAAAGTTAGCCAAGGAGTAGAAGATGGGCCCG
ACACCAAGAGAGCAAAACTTGATTCTTCTGAGACAACGATGGTCAAAAAGAAGGTGGTCTTCTGCCCTGTTAAAGAAGCCCTGGAGGTGG
ACTGGAGCAGTGAGAAAGCAAAGGCTGCTCTGAAGCGCACGACCTCCGACTACTTTCTCCTTCAAGGACTGAGCACGGAAGGCATCTACC
GGGTCAGCGGGAACAAGTCTGAGATGGAGAGTCTGCAGAGACAGTTTGATCAAGACCACAACCTGGACCTGGCAGAGAAAGACTTTACGG
TGAATACCGTGGCTGGTGCCATGAAGAGCTTTTTCTCAGAACTGCCTGACCCCCTGGTCCCGTATAACATGCAGATCGACTTGGTGGAAG
CACACAAAATCAACGACCGGGAGCAGAAGTTGCATGCCCTTAAGGAGGTATTAAAGAAATTTCCAAAGGAAAACCACGAAGTCTTCAAGT
ATGTCATCTCTCACCTAAACAAGGTCAGCCACAACAACAAGGTGAATCTCATGACCAGCGAGAACCTCTCCATCTGCTTCTGGCCCACCT
TGATGAGACCTGATTTCAGCACTATGGACGCCCTCACAGCCACGCGCACCTACCAGACAATCATTGAACTCTTTATCCAGCAGTGCCCCT
TCTTCTTCTACAATCGGCCCATCACCGAGCCCCCCGGCGCCAGGCCCAGCTCCCCCTCTGCCGTGGCTTCCACCGTCCCCTTCCTCACTT
CCACGCCTGTCACAAGTCAGCCGTCGCCCCCACAGTCGCCTCCACCCACCCCCCAGTCCCCAATGCAGCCACTGCTTCCCTCCCAGCTTC
AAGCCGAACACACGCTGTGAGCCACCAAGACCTGGGGCGACAGGAGAACCGGTCCTCTCTCTGACGGGGTGGCATTTGGCCTTGAACAAA
ACCAAGTCCACTGGGGACAGAGGCAGGGGCAAGTGGCTCTCCCCATTACCTTCTCAAGACCTCAGTGGGAGCACCAGCCAATGGTACCAT
CGGCTGGGCTGCCAGGTACCCTGGGCCTGGCGCTGCAGACCTGAGCTGGCTTGGACCCATTTGAGGACTGAACTAGGCAGGCAATGGCTC
CAGTGCCCTCCCTCTGTTCCCTGGACCACCACCCCACGTAGCTGCTCACACCAGCCTCCGGGTGCCTCCCTCTGCTTGTACAGAGCCCAT
GGTCGGGACAGTGCCCTGGCCTTTGCCGGGGAGGAGGATGCTCTGAGATTCAGGGTGGGGCTGGCAACCCCTGAAGAGAACACTTCCTGT
TGGTCTGTCTCTTCCCACCTTCCATCTGCACACACCCCCAAGGTAAGGGTACAGCCCGGCTGGCGGCCTCCTTGGGAACGTGTAGGCCAC
GGCTCTGCCACCACTAGGTACCTGCTGAGGGCGCTGGCTCTGCAGATCAGAACAACGGAGGATAGCTTTGTGCCTGGACCCAGAGAGTGT
GGGACTCCCCGCTTCATCCCCACCGTCCCACTCCACAGCCTTCCCGAAACATTCCCTGGCAAACAAAGGAACACTAGGAGAAAAAATGGA
AAAACCCTTCCAGTAATTAAAAAGGAAGAAACCACAGAAAGAAAACTACAGACCTCAAGATTCCACTCTGTGCCCGCCTCTGCCGGGAGG
GAGGGAGGCACACAGGTGGAGCTGACCCTCGTCTTTGTGGCAGCAAAACCAGGATGCCTGGAGCTGTGGCCTGAGGGCCTGCTGGGGTCC
CACTCACCCACTTAGGTCTAGTCGCTAGATCCCCCGTTTTCCCAAGAAGAGGGTTCGAGCCCTTGGTGGGGACAGCTGGGGAGATGGCAG
TGCAGGCTGGAACCTGGGCTGCCCCAGAACACAGTCCATTACGATAGAAACACTAATTGAGCATGTGCGTGGGGTGGGGGTGTGTGTGCA
CATGTGAGTGTGAGTGTGTGTGGGCGCTTGGTGGGGGGTTGGGGACAGCTGGAAGGTGCCAGGTGCACTTGGGGTTGGGGTTGGTGTGTT
GGGTGTTGAAGTGGAATCGTTTCATCCCAGCCATGGAGGCCACCAGCAGGAGTGTTCATGGGGATGTGGGCGAGGTGGGGCACTTTGAAG
GAATGGCGGTCTGCTGGTGCCCTCGAAGGGGCATCCTTCCTGGTCTTCGCTGACCCAGAGGCGCTGTGCCTGCATATCATCCACCACCAC
CCTAGCCCAGCCTTCCCACTGCCCCAGGAAAAGCTCTTCTCCTGGCCACCTCTGCCCCCCAGCACCTCAAACTTGCATGGCTGGGCTGTG
GCCTCTGCGGCCAGGAAGCCTGACACTAGGCACCCCCCAGGCGAGAGCTAGTGGGGTGCAGAGGGCCCCATGCCAGACAGCCCTTGGGGC
TCGTTGCACTTTAAGAAATAGGATCTGTGGTGTATTCCAGGGGGCCTGATGGACACCTTTCCCGGGCGTCTGCAGCTGCCCTGCCCGTGC
CCGCCTGCAGTGGTTGGAGACGGGAGTGGCCCTTCGGCTCCCGAGCTCCCTCTGGGGACGGCTGGCTCACTGTCTCCAGTTCTCAATGGC
CAACGAAGGTGCTTGGAAACACCTAACCTTGCAAGTTTTACCGCCTTTTGAGGAACACAAATCGGAGAACAAACCCAGGGTTCAGGCGTG
TTTTCTGTGAATGTTGGATGATGAATTTTTGTCTCTTCTGGTGGAGCTGTGCCTGGCCCTGTAGGCCCAGGGTTGGCTGGAAGGTGACAT
CTGTGTTTCGTTTTAGCTGAGGTTGGCAGAAACGTTCCCAAACTCCCCCAGCCCTGGACCCCAGCAGATGAGGAAACGGCCCCATTTACT
GACCCCGCCCCCTTTTCGAGGTTATGCTCACCTGGTCAGCTCCTCACGTAATTGGGGGTGGAGGGAAAGCATGGTGGTGCCCTGGGCCGT
CCCTGTGTGAACGCAGGCAAAAGCAGCCCAGTCCCCCTCACTGCTTGAGCTAACACTGCCACCTCTTTTGTGTGAGCACAAAAGCCACGT
CCCAAGCCACCTGGCCCGATTCCACAGATGTATGTGCGGCCAGTGACTTCCCCAGGAGTGTGGAGGGGGTGGTGAGGAGGAGCACCTGGG
CTCTCTACCCCTCTCCTCACAGAAGTACCTGAAACTAGGTCTGGGGCACTCCCAATGCAGCGCCTTGTCAGCCAAGGTGGGCAGGCAGGG
ACTGTGGCAGCTTATGTCCAAAGGGAGCCCCCATGCACAGGAAGCCACAGGGTTCCTCTTGTTTCCCCCGCTAACTTCAGCCTCTCATCT
GCTGCTCCGGGCTGAGGGACTAGAGGACATCTCGGTCGTTTGAGGGGCATGGCCAGTCGTGGCAGGCCGGCCTTCAGCGTCCGGTCAGGG
AAGCGTGCAGCCCAAATGGGCACTTGCATGGGAGCCACAGAGGAGCGTCCCTGGGGATTGTTGGGACCATGCTGCCCCCACTCCCGCTTT
TGTTGGGGCTCTAAGTTCTGGAAGGTGTGTGCACAGAGGGTGCTCATGGGACTCGCATGCAGCTCTCAGCACTGGGTGGGAGGGCGTTGG
CTTGTCCAGAATGGGGACGTGGGGCAGCCACCCCTGCCCAGCGAGAGCGCAGACACCGTGTGAGGGGACAGCAGCCCTTGGTGCAAAGCC
AGAGACTGATCCTGGCTCTGACGGCTGAAGAGGGAAGACCCAAGGCTGGGTGGCGTGGCTCGTGAATCCACTTAGAATTCTTGGCTTGTG
TCGCATACTGGGTGTCACGGCACACATTTACTCTGCATTGTCCCCGTCTTTCCCATCGCCTAGCGTTTGGGGAGGAACAGGGAGAGAGCT
TCGGGGCGTCTGTCTCCGTGCTCTCCTGCCTCCACCGCCTTGGTTTTGCTTCCTGCTGGAGGCAGGGCACCTGCTGCGACCCAGATTCTT
CTGCAGGATGTGTCTGTCTTTGTCACGGTGGACAGAGGGTGACATCATAGGAGCAGCTCGCTGGCCAGAAGGGGATGGGGGCATCCCTGT
GCCTCACTCAGCTCCTGCTGCTCTTAGGGAAAGGAGGCCTGGGTCAAGCCAGCATCCCCTTGGTAAAGACCCCCGCAGGCCACCAGGCAT
TCTGGACACGCACACACACACACACACACACACACACACACAAAACTTCACAGCAGGCCAGCTGCAGTGACTTGTCATCAAGAGTCACCT
CAGCTGCGCCCCCCTCCCATCCTTTCCTATGAGAAGCCACTGCTTTGGGGGCGCCGGCTAGAAAAAGTAGGGTGCGGTGGCCAGGAGGGC
CCCTGCCGCGCGGGGGGCTGGGTCTGGTTGAGTCGCTGCTTTCCCGAGGGCAGCGCAGGGATCCGGGGAAGCTGCGGCAGGGAGCGGGCG
CCGGCTTCGTGGCTCTGAGGTGTAACGGGGGTGGGCTCCCTCCCTCGGAGGACATCGTCTGTGTCCAGGTCAGAAAGTGGCCCAGGAAGG
GGGCAGTTTCTGTCGCGGGTCCGGTGGGGGCGCGGCCGCGGTGCGGTCGGTGCAGCGTGGCCAATGCGCGGCGCGCGCGGGGGACAGAGC
AGGAGGCGGTCTGTCACCTCGGCCACTGCTGACCTGGGCTGGCCTCCCCCAGCCCTCCCGTGGCGGAGCCGGCAGCGATGCTACAGGCCT
AAGTTATTGTTTGCATAAAAAGAATCATGTTCCCTGTGTACATTTAAGAAAAAAACAAAAAAACGGAAATGTCAGAATTGTATGGAAATA
AAACTTGTTTGAAAATTTGGAATAGTGCTGCTGCCAGCTTATTTTTCTGGTACTTGTATTTTCACATGTTAAATGATCTTTATATATGTT
GAATTAACAAATATTTTGAGTTTCTGAGAAAAAACAAAACATATTAATGGTATTGAAATGTGTTAGTAGTCTGGCTGTGTGCCCAAAATT
CTGTTTCGCAGCAAAAGTGAAGACCTGTATGTAAAGAAAGTATAACAATTATTTCTTTGTATTTTAGGGGCTTTAACCGGAACATCGTCT
AGCTGGTGTTAGGAATGTTTGCTTAATTTCCAGACTTTTTTTTAAAAACACATCGTGGGTTTTTTGAGGCTCCAACCTGATTAGTGCATG
GTCAGCCCTCAATGAAGGCTGAGGCATCTCTGACTGAGGTGTTTTTGTTTGGTTTTGTTTTTTAAAATCATGTATTTGCTACAAAGTATT

>79004_79004_4_SAE1-ARHGAP35_SAE1_chr19_47673180_ENST00000540850_ARHGAP35_chr19_47491246_ENST00000404338_length(amino acids)=391AA_BP=
MISALWTPSQPRAPTRQSLNSLSSSAPSSSTIGPSPSPPAPGPAPPLPWLPPSPSSLPRLSQVSRRPHSRLHPPPSPQCSHCFPPSFKPN
TRCEPPRPGATGEPVLSLTGWHLALNKTKSTGDRGRGKWLSPLPSQDLSGSTSQWYHRLGCQVPWAWRCRPELAWTHLRTELGRQWLQCP
PSVPWTTTPRSCSHQPPGASLCLYRAHGRDSALAFAGEEDALRFRVGLATPEENTSCWSVSSHLPSAHTPKVRVQPGWRPPWERVGHGSA
TTRYLLRALALQIRTTEDSFVPGPRECGTPRFIPTVPLHSLPETFPGKQRNTRRKNGKTLPVIKKEETTERKLQTSRFHSVPASAGREGG

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>79004_79004_5_SAE1-ARHGAP35_SAE1_chr19_47673180_ENST00000598840_ARHGAP35_chr19_47491246_ENST00000404338_length(transcript)=5646nt_BP=583nt
CCGGGCGTGCTGCCGGCGGCGGTAGGTGGCGCGCGGGTCCGGCGGGCGGTTGGCTTGAGCGGGACCGGAGCTGAGGCAGGAAGAGCCGGC
GCCATGGTGGAGAAGGAGGAGGCTGGCGGCGGCATTAGCGAGGAGGAGGCGGCACAGTATGACCGGCAGATCCGCCTGTGGGGACTGGAG
GCCCAGAAACGGCTGCGGGCCTCTCGGGTGCTTCTTGTCGGCTTGAAAGGACTTGGGGCTGAAATTGCCAAGAATCTCATCTTGGCAGGA
GTGAAAGGACTGACCATGCTGGATCACGAACAGGTAACTCCAGAAGATCCCGGAGCTCAGTTCTTGATTCGTACTGGGTCTGTTGGCCGA
AATAGGGCTGAAGCCTCTTTGGAGCGAGCTCAGAATCTCAACCCCATGGTGGATGTGAAGGTGGACACTGAGGATATAGAGAAGAAACCA
GAGTCATTTTTCACTCAATTCGATGCTAAGGTGGTCTTCTGCCCTGTTAAAGAAGCCCTGGAGGTGGACTGGAGCAGTGAGAAAGCAAAG
GCTGCTCTGAAGCGCACGACCTCCGACTACTTTCTCCTTCAAGGACTGAGCACGGAAGGCATCTACCGGGTCAGCGGGAACAAGTCTGAG
ATGGAGAGTCTGCAGAGACAGTTTGATCAAGACCACAACCTGGACCTGGCAGAGAAAGACTTTACGGTGAATACCGTGGCTGGTGCCATG
AAGAGCTTTTTCTCAGAACTGCCTGACCCCCTGGTCCCGTATAACATGCAGATCGACTTGGTGGAAGCACACAAAATCAACGACCGGGAG
CAGAAGTTGCATGCCCTTAAGGAGGTATTAAAGAAATTTCCAAAGGAAAACCACGAAGTCTTCAAGTATGTCATCTCTCACCTAAACAAG
GTCAGCCACAACAACAAGGTGAATCTCATGACCAGCGAGAACCTCTCCATCTGCTTCTGGCCCACCTTGATGAGACCTGATTTCAGCACT
ATGGACGCCCTCACAGCCACGCGCACCTACCAGACAATCATTGAACTCTTTATCCAGCAGTGCCCCTTCTTCTTCTACAATCGGCCCATC
ACCGAGCCCCCCGGCGCCAGGCCCAGCTCCCCCTCTGCCGTGGCTTCCACCGTCCCCTTCCTCACTTCCACGCCTGTCACAAGTCAGCCG
TCGCCCCCACAGTCGCCTCCACCCACCCCCCAGTCCCCAATGCAGCCACTGCTTCCCTCCCAGCTTCAAGCCGAACACACGCTGTGAGCC
ACCAAGACCTGGGGCGACAGGAGAACCGGTCCTCTCTCTGACGGGGTGGCATTTGGCCTTGAACAAAACCAAGTCCACTGGGGACAGAGG
CAGGGGCAAGTGGCTCTCCCCATTACCTTCTCAAGACCTCAGTGGGAGCACCAGCCAATGGTACCATCGGCTGGGCTGCCAGGTACCCTG
GGCCTGGCGCTGCAGACCTGAGCTGGCTTGGACCCATTTGAGGACTGAACTAGGCAGGCAATGGCTCCAGTGCCCTCCCTCTGTTCCCTG
GACCACCACCCCACGTAGCTGCTCACACCAGCCTCCGGGTGCCTCCCTCTGCTTGTACAGAGCCCATGGTCGGGACAGTGCCCTGGCCTT
TGCCGGGGAGGAGGATGCTCTGAGATTCAGGGTGGGGCTGGCAACCCCTGAAGAGAACACTTCCTGTTGGTCTGTCTCTTCCCACCTTCC
ATCTGCACACACCCCCAAGGTAAGGGTACAGCCCGGCTGGCGGCCTCCTTGGGAACGTGTAGGCCACGGCTCTGCCACCACTAGGTACCT
GCTGAGGGCGCTGGCTCTGCAGATCAGAACAACGGAGGATAGCTTTGTGCCTGGACCCAGAGAGTGTGGGACTCCCCGCTTCATCCCCAC
CGTCCCACTCCACAGCCTTCCCGAAACATTCCCTGGCAAACAAAGGAACACTAGGAGAAAAAATGGAAAAACCCTTCCAGTAATTAAAAA
GGAAGAAACCACAGAAAGAAAACTACAGACCTCAAGATTCCACTCTGTGCCCGCCTCTGCCGGGAGGGAGGGAGGCACACAGGTGGAGCT
GACCCTCGTCTTTGTGGCAGCAAAACCAGGATGCCTGGAGCTGTGGCCTGAGGGCCTGCTGGGGTCCCACTCACCCACTTAGGTCTAGTC
GCTAGATCCCCCGTTTTCCCAAGAAGAGGGTTCGAGCCCTTGGTGGGGACAGCTGGGGAGATGGCAGTGCAGGCTGGAACCTGGGCTGCC
CCAGAACACAGTCCATTACGATAGAAACACTAATTGAGCATGTGCGTGGGGTGGGGGTGTGTGTGCACATGTGAGTGTGAGTGTGTGTGG
GCGCTTGGTGGGGGGTTGGGGACAGCTGGAAGGTGCCAGGTGCACTTGGGGTTGGGGTTGGTGTGTTGGGTGTTGAAGTGGAATCGTTTC
ATCCCAGCCATGGAGGCCACCAGCAGGAGTGTTCATGGGGATGTGGGCGAGGTGGGGCACTTTGAAGGAATGGCGGTCTGCTGGTGCCCT
CGAAGGGGCATCCTTCCTGGTCTTCGCTGACCCAGAGGCGCTGTGCCTGCATATCATCCACCACCACCCTAGCCCAGCCTTCCCACTGCC
CCAGGAAAAGCTCTTCTCCTGGCCACCTCTGCCCCCCAGCACCTCAAACTTGCATGGCTGGGCTGTGGCCTCTGCGGCCAGGAAGCCTGA
CACTAGGCACCCCCCAGGCGAGAGCTAGTGGGGTGCAGAGGGCCCCATGCCAGACAGCCCTTGGGGCTCGTTGCACTTTAAGAAATAGGA
TCTGTGGTGTATTCCAGGGGGCCTGATGGACACCTTTCCCGGGCGTCTGCAGCTGCCCTGCCCGTGCCCGCCTGCAGTGGTTGGAGACGG
GAGTGGCCCTTCGGCTCCCGAGCTCCCTCTGGGGACGGCTGGCTCACTGTCTCCAGTTCTCAATGGCCAACGAAGGTGCTTGGAAACACC
TAACCTTGCAAGTTTTACCGCCTTTTGAGGAACACAAATCGGAGAACAAACCCAGGGTTCAGGCGTGTTTTCTGTGAATGTTGGATGATG
AATTTTTGTCTCTTCTGGTGGAGCTGTGCCTGGCCCTGTAGGCCCAGGGTTGGCTGGAAGGTGACATCTGTGTTTCGTTTTAGCTGAGGT
TGGCAGAAACGTTCCCAAACTCCCCCAGCCCTGGACCCCAGCAGATGAGGAAACGGCCCCATTTACTGACCCCGCCCCCTTTTCGAGGTT
ATGCTCACCTGGTCAGCTCCTCACGTAATTGGGGGTGGAGGGAAAGCATGGTGGTGCCCTGGGCCGTCCCTGTGTGAACGCAGGCAAAAG
CAGCCCAGTCCCCCTCACTGCTTGAGCTAACACTGCCACCTCTTTTGTGTGAGCACAAAAGCCACGTCCCAAGCCACCTGGCCCGATTCC
ACAGATGTATGTGCGGCCAGTGACTTCCCCAGGAGTGTGGAGGGGGTGGTGAGGAGGAGCACCTGGGCTCTCTACCCCTCTCCTCACAGA
AGTACCTGAAACTAGGTCTGGGGCACTCCCAATGCAGCGCCTTGTCAGCCAAGGTGGGCAGGCAGGGACTGTGGCAGCTTATGTCCAAAG
GGAGCCCCCATGCACAGGAAGCCACAGGGTTCCTCTTGTTTCCCCCGCTAACTTCAGCCTCTCATCTGCTGCTCCGGGCTGAGGGACTAG
AGGACATCTCGGTCGTTTGAGGGGCATGGCCAGTCGTGGCAGGCCGGCCTTCAGCGTCCGGTCAGGGAAGCGTGCAGCCCAAATGGGCAC
TTGCATGGGAGCCACAGAGGAGCGTCCCTGGGGATTGTTGGGACCATGCTGCCCCCACTCCCGCTTTTGTTGGGGCTCTAAGTTCTGGAA
GGTGTGTGCACAGAGGGTGCTCATGGGACTCGCATGCAGCTCTCAGCACTGGGTGGGAGGGCGTTGGCTTGTCCAGAATGGGGACGTGGG
GCAGCCACCCCTGCCCAGCGAGAGCGCAGACACCGTGTGAGGGGACAGCAGCCCTTGGTGCAAAGCCAGAGACTGATCCTGGCTCTGACG
GCTGAAGAGGGAAGACCCAAGGCTGGGTGGCGTGGCTCGTGAATCCACTTAGAATTCTTGGCTTGTGTCGCATACTGGGTGTCACGGCAC
ACATTTACTCTGCATTGTCCCCGTCTTTCCCATCGCCTAGCGTTTGGGGAGGAACAGGGAGAGAGCTTCGGGGCGTCTGTCTCCGTGCTC
TCCTGCCTCCACCGCCTTGGTTTTGCTTCCTGCTGGAGGCAGGGCACCTGCTGCGACCCAGATTCTTCTGCAGGATGTGTCTGTCTTTGT
CACGGTGGACAGAGGGTGACATCATAGGAGCAGCTCGCTGGCCAGAAGGGGATGGGGGCATCCCTGTGCCTCACTCAGCTCCTGCTGCTC
TTAGGGAAAGGAGGCCTGGGTCAAGCCAGCATCCCCTTGGTAAAGACCCCCGCAGGCCACCAGGCATTCTGGACACGCACACACACACAC
ACACACACACACACACACAAAACTTCACAGCAGGCCAGCTGCAGTGACTTGTCATCAAGAGTCACCTCAGCTGCGCCCCCCTCCCATCCT
TTCCTATGAGAAGCCACTGCTTTGGGGGCGCCGGCTAGAAAAAGTAGGGTGCGGTGGCCAGGAGGGCCCCTGCCGCGCGGGGGGCTGGGT
CTGGTTGAGTCGCTGCTTTCCCGAGGGCAGCGCAGGGATCCGGGGAAGCTGCGGCAGGGAGCGGGCGCCGGCTTCGTGGCTCTGAGGTGT
AACGGGGGTGGGCTCCCTCCCTCGGAGGACATCGTCTGTGTCCAGGTCAGAAAGTGGCCCAGGAAGGGGGCAGTTTCTGTCGCGGGTCCG
GTGGGGGCGCGGCCGCGGTGCGGTCGGTGCAGCGTGGCCAATGCGCGGCGCGCGCGGGGGACAGAGCAGGAGGCGGTCTGTCACCTCGGC
CACTGCTGACCTGGGCTGGCCTCCCCCAGCCCTCCCGTGGCGGAGCCGGCAGCGATGCTACAGGCCTAAGTTATTGTTTGCATAAAAAGA
ATCATGTTCCCTGTGTACATTTAAGAAAAAAACAAAAAAACGGAAATGTCAGAATTGTATGGAAATAAAACTTGTTTGAAAATTTGGAAT
AGTGCTGCTGCCAGCTTATTTTTCTGGTACTTGTATTTTCACATGTTAAATGATCTTTATATATGTTGAATTAACAAATATTTTGAGTTT
CTGAGAAAAAACAAAACATATTAATGGTATTGAAATGTGTTAGTAGTCTGGCTGTGTGCCCAAAATTCTGTTTCGCAGCAAAAGTGAAGA
CCTGTATGTAAAGAAAGTATAACAATTATTTCTTTGTATTTTAGGGGCTTTAACCGGAACATCGTCTAGCTGGTGTTAGGAATGTTTGCT
TAATTTCCAGACTTTTTTTTAAAAACACATCGTGGGTTTTTTGAGGCTCCAACCTGATTAGTGCATGGTCAGCCCTCAATGAAGGCTGAG
GCATCTCTGACTGAGGTGTTTTTGTTTGGTTTTGTTTTTTAAAATCATGTATTTGCTACAAAGTATTGTACTTGTCTCAATGGGAATGGT

>79004_79004_5_SAE1-ARHGAP35_SAE1_chr19_47673180_ENST00000598840_ARHGAP35_chr19_47491246_ENST00000404338_length(amino acids)=415AA_BP=191
MPAAVGGARVRRAVGLSGTGAEAGRAGAMVEKEEAGGGISEEEAAQYDRQIRLWGLEAQKRLRASRVLLVGLKGLGAEIAKNLILAGVKG
LTMLDHEQVTPEDPGAQFLIRTGSVGRNRAEASLERAQNLNPMVDVKVDTEDIEKKPESFFTQFDAKVVFCPVKEALEVDWSSEKAKAAL
KRTTSDYFLLQGLSTEGIYRVSGNKSEMESLQRQFDQDHNLDLAEKDFTVNTVAGAMKSFFSELPDPLVPYNMQIDLVEAHKINDREQKL
HALKEVLKKFPKENHEVFKYVISHLNKVSHNNKVNLMTSENLSICFWPTLMRPDFSTMDALTATRTYQTIIELFIQQCPFFFYNRPITEP

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Fusion Gene PPI Analysis for SAE1-ARHGAP35


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for SAE1-ARHGAP35


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for SAE1-ARHGAP35


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource