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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:SAMD12-TG (FusionGDB2 ID:79063)

Fusion Gene Summary for SAMD12-TG

check button Fusion gene summary
Fusion gene informationFusion gene name: SAMD12-TG
Fusion gene ID: 79063
HgeneTgene
Gene symbol

SAMD12

TG

Gene ID

401474

7038

Gene namesterile alpha motif domain containing 12thyroglobulin
Synonyms-AITD3|TGN
Cytomap

8q24.11-q24.12

8q24.22

Type of geneprotein-codingprotein-coding
Descriptionsterile alpha motif domain-containing protein 12SAM domain-containing protein 12thyroglobulin
Modification date2020031320200313
UniProtAcc.

TIAF1

Ensembl transtripts involved in fusion geneENST00000314727, ENST00000409003, 
ENST00000527515, 		ENST00000519543, 
ENST00000522523, ENST00000542445, 
ENST00000220616, ENST00000377869, 
Fusion gene scores* DoF score17 X 11 X 6=112227 X 26 X 8=5616
# samples 2229
** MAII scorelog2(22/1122*10)=-2.35049724708413
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(29/5616*10)=-4.27541813028963
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SAMD12 [Title/Abstract] AND TG [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointSAMD12(119592954)-TG(133923622), # samples:2
Anticipated loss of major functional domain due to fusion event.SAMD12-TG seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across SAMD12 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across TG (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUSCTCGA-21-5783-01ASAMD12chr8

119592954

-TGchr8

133923622

+
ChimerDB4LUSCTCGA-21-5783SAMD12chr8

119592954

-TGchr8

133923622

+
ChimerDB4LUSCTCGA-21-5783SAMD12chr8

119592954

-TGchr8

133925292

+


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Fusion Gene ORF analysis for SAMD12-TG

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000314727ENST00000519543SAMD12chr8

119592954

-TGchr8

133923622

+
5CDS-intronENST00000314727ENST00000519543SAMD12chr8

119592954

-TGchr8

133925292

+
5CDS-intronENST00000314727ENST00000522523SAMD12chr8

119592954

-TGchr8

133923622

+
5CDS-intronENST00000314727ENST00000522523SAMD12chr8

119592954

-TGchr8

133925292

+
5CDS-intronENST00000314727ENST00000542445SAMD12chr8

119592954

-TGchr8

133923622

+
5CDS-intronENST00000314727ENST00000542445SAMD12chr8

119592954

-TGchr8

133925292

+
5CDS-intronENST00000409003ENST00000519543SAMD12chr8

119592954

-TGchr8

133923622

+
5CDS-intronENST00000409003ENST00000519543SAMD12chr8

119592954

-TGchr8

133925292

+
5CDS-intronENST00000409003ENST00000522523SAMD12chr8

119592954

-TGchr8

133923622

+
5CDS-intronENST00000409003ENST00000522523SAMD12chr8

119592954

-TGchr8

133925292

+
5CDS-intronENST00000409003ENST00000542445SAMD12chr8

119592954

-TGchr8

133923622

+
5CDS-intronENST00000409003ENST00000542445SAMD12chr8

119592954

-TGchr8

133925292

+
Frame-shiftENST00000314727ENST00000220616SAMD12chr8

119592954

-TGchr8

133925292

+
Frame-shiftENST00000314727ENST00000377869SAMD12chr8

119592954

-TGchr8

133925292

+
Frame-shiftENST00000409003ENST00000220616SAMD12chr8

119592954

-TGchr8

133925292

+
Frame-shiftENST00000409003ENST00000377869SAMD12chr8

119592954

-TGchr8

133925292

+
In-frameENST00000314727ENST00000220616SAMD12chr8

119592954

-TGchr8

133923622

+
In-frameENST00000314727ENST00000377869SAMD12chr8

119592954

-TGchr8

133923622

+
In-frameENST00000409003ENST00000220616SAMD12chr8

119592954

-TGchr8

133923622

+
In-frameENST00000409003ENST00000377869SAMD12chr8

119592954

-TGchr8

133923622

+
intron-3CDSENST00000527515ENST00000220616SAMD12chr8

119592954

-TGchr8

133923622

+
intron-3CDSENST00000527515ENST00000220616SAMD12chr8

119592954

-TGchr8

133925292

+
intron-3CDSENST00000527515ENST00000377869SAMD12chr8

119592954

-TGchr8

133923622

+
intron-3CDSENST00000527515ENST00000377869SAMD12chr8

119592954

-TGchr8

133925292

+
intron-intronENST00000527515ENST00000519543SAMD12chr8

119592954

-TGchr8

133923622

+
intron-intronENST00000527515ENST00000519543SAMD12chr8

119592954

-TGchr8

133925292

+
intron-intronENST00000527515ENST00000522523SAMD12chr8

119592954

-TGchr8

133923622

+
intron-intronENST00000527515ENST00000522523SAMD12chr8

119592954

-TGchr8

133925292

+
intron-intronENST00000527515ENST00000542445SAMD12chr8

119592954

-TGchr8

133923622

+
intron-intronENST00000527515ENST00000542445SAMD12chr8

119592954

-TGchr8

133925292

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000409003SAMD12chr8119592954-ENST00000377869TGchr8133923622+456032112944541441
ENST00000409003SAMD12chr8119592954-ENST00000220616TGchr8133923622+472932112946251498
ENST00000314727SAMD12chr8119592954-ENST00000377869TGchr8133923622+456832913744621441
ENST00000314727SAMD12chr8119592954-ENST00000220616TGchr8133923622+473732913746331498

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000409003ENST00000377869SAMD12chr8119592954-TGchr8133923622+0.0017169080.99828315
ENST00000409003ENST00000220616SAMD12chr8119592954-TGchr8133923622+0.0016921610.9983078
ENST00000314727ENST00000377869SAMD12chr8119592954-TGchr8133923622+0.0017171990.9982828
ENST00000314727ENST00000220616SAMD12chr8119592954-TGchr8133923622+0.0016907840.99830925

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Fusion Genomic Features for SAMD12-TG


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
SAMD12chr8119592953-TGchr8133925291+0.0105739350.989426
SAMD12chr8119592953-TGchr8133923621+0.000169470.9998305
SAMD12chr8119592953-TGchr8133923621+0.000169470.9998305
SAMD12chr8119592953-TGchr8133925291+0.0105739350.989426
SAMD12chr8119592953-TGchr8133923621+0.000169470.9998305
SAMD12chr8119592953-TGchr8133923621+0.000169470.9998305

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for SAMD12-TG


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr8:119592954/chr8:133923622)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.TG

TIAF1

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.115

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneTGchr8:119592954chr8:133923622ENST0000022061617481511_156513342769.0DomainThyroglobulin type-1 11
TgeneTGchr8:119592954chr8:133923622ENST0000037786917471511_156513342712.0DomainThyroglobulin type-1 11
TgeneTGchr8:119592954chr8:133923622ENST0000022061617482188_276813342769.0RegionCholinesterase-like (ChEL)
TgeneTGchr8:119592954chr8:133923622ENST0000037786917472188_276813342712.0RegionCholinesterase-like (ChEL)
TgeneTGchr8:119592954chr8:133923622ENST0000022061617481456_146913342769.0RepeatType II
TgeneTGchr8:119592954chr8:133923622ENST0000022061617481470_148613342769.0RepeatType II
TgeneTGchr8:119592954chr8:133923622ENST0000022061617481487_150313342769.0RepeatType II
TgeneTGchr8:119592954chr8:133923622ENST0000022061617481603_172313342769.0RepeatType IIIA
TgeneTGchr8:119592954chr8:133923622ENST0000022061617481724_189213342769.0RepeatType IIIB
TgeneTGchr8:119592954chr8:133923622ENST0000022061617481893_199513342769.0RepeatType IIIA
TgeneTGchr8:119592954chr8:133923622ENST0000022061617481996_212913342769.0RepeatType IIIB
TgeneTGchr8:119592954chr8:133923622ENST0000022061617482130_218713342769.0RepeatType IIIA
TgeneTGchr8:119592954chr8:133923622ENST0000037786917471456_146913342712.0RepeatType II
TgeneTGchr8:119592954chr8:133923622ENST0000037786917471470_148613342712.0RepeatType II
TgeneTGchr8:119592954chr8:133923622ENST0000037786917471487_150313342712.0RepeatType II
TgeneTGchr8:119592954chr8:133923622ENST0000037786917471603_172313342712.0RepeatType IIIA
TgeneTGchr8:119592954chr8:133923622ENST0000037786917471724_189213342712.0RepeatType IIIB
TgeneTGchr8:119592954chr8:133923622ENST0000037786917471893_199513342712.0RepeatType IIIA
TgeneTGchr8:119592954chr8:133923622ENST0000037786917471996_212913342712.0RepeatType IIIB
TgeneTGchr8:119592954chr8:133923622ENST0000037786917472130_218713342712.0RepeatType IIIA

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSAMD12chr8:119592954chr8:133923622ENST00000314727-2477_14364202.0DomainSAM
TgeneTGchr8:119592954chr8:133923622ENST0000022061617481074_114513342769.0DomainThyroglobulin type-1 9
TgeneTGchr8:119592954chr8:133923622ENST0000022061617481146_121013342769.0DomainThyroglobulin type-1 10
TgeneTGchr8:119592954chr8:133923622ENST000002206161748161_29713342769.0DomainThyroglobulin type-1 3
TgeneTGchr8:119592954chr8:133923622ENST000002206161748298_35813342769.0DomainThyroglobulin type-1 4
TgeneTGchr8:119592954chr8:133923622ENST00000220616174831_9213342769.0DomainThyroglobulin type-1 1
TgeneTGchr8:119592954chr8:133923622ENST000002206161748605_65813342769.0DomainThyroglobulin type-1 5
TgeneTGchr8:119592954chr8:133923622ENST000002206161748659_72613342769.0DomainThyroglobulin type-1 6
TgeneTGchr8:119592954chr8:133923622ENST000002206161748727_92113342769.0DomainThyroglobulin type-1 7
TgeneTGchr8:119592954chr8:133923622ENST000002206161748922_107313342769.0DomainThyroglobulin type-1 8
TgeneTGchr8:119592954chr8:133923622ENST00000220616174893_16013342769.0DomainThyroglobulin type-1 2
TgeneTGchr8:119592954chr8:133923622ENST0000037786917471074_114513342712.0DomainThyroglobulin type-1 9
TgeneTGchr8:119592954chr8:133923622ENST0000037786917471146_121013342712.0DomainThyroglobulin type-1 10
TgeneTGchr8:119592954chr8:133923622ENST000003778691747161_29713342712.0DomainThyroglobulin type-1 3
TgeneTGchr8:119592954chr8:133923622ENST000003778691747298_35813342712.0DomainThyroglobulin type-1 4
TgeneTGchr8:119592954chr8:133923622ENST00000377869174731_9213342712.0DomainThyroglobulin type-1 1
TgeneTGchr8:119592954chr8:133923622ENST000003778691747605_65813342712.0DomainThyroglobulin type-1 5
TgeneTGchr8:119592954chr8:133923622ENST000003778691747659_72613342712.0DomainThyroglobulin type-1 6
TgeneTGchr8:119592954chr8:133923622ENST000003778691747727_92113342712.0DomainThyroglobulin type-1 7
TgeneTGchr8:119592954chr8:133923622ENST000003778691747922_107313342712.0DomainThyroglobulin type-1 8
TgeneTGchr8:119592954chr8:133923622ENST00000377869174793_16013342712.0DomainThyroglobulin type-1 2


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Fusion Gene Sequence for SAMD12-TG


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>79063_79063_1_SAMD12-TG_SAMD12_chr8_119592954_ENST00000314727_TG_chr8_133923622_ENST00000220616_length(transcript)=4737nt_BP=329nt
GCGTGACCGCGGCAGGTTGGTCCTGGAGCAGATAAGCGCAGAATATTTAGGCGAAAGCGAGAGGAAGGGGGGAGCGCGGGGCAGGAGGAG
TACCTCGGCCAAGAAAATTATGCATGCGTTAGGGAAGCTCTGAGAGAATGGCTGTGGAAGCTCTCCACTGTGGTTTGAATCCACGGGGTA
TTGATCACCCTGCCCATGCTGAAGGTATTAAACTGCAAATTGAAGGTGAAGGTGTGGAATCTCAATCCATTAAAAATAAAAATTTCCAGA
AGGTGCCTGACCAGAAAGGAACTCCCAAGCGACTGCAGGCAGAAGCTGAGACGGCTAAGGTGAAGACTTTTGGCACCCTGGTTTCCATTC
CTGTCTGCAACAACTCCTCTGTGCAGGTGGGTTGTCTGACCAGGGAGCGTTTAGGAGTGAATGTTACATGGAAATCACGGCTTGAGGACA
TCCCAGTGGCTTCTCTTCCTGACTTACATGACATTGAGAGAGCCTTGGTGGGCAAGGATCTCCTTGGGCGCTTCACAGATCTGATCCAGA
GTGGCTCATTCCAGCTTCATCTGGACTCCAAGACGTTCCCAGCGGAAACCATCCGCTTCCTCCAAGGGGACCACTTTGGCACCTCTCCCA
GGACATGGTTTGGGTGCTCGGAAGGATTCTACCAAGTCTTGACAAGTGAGGCCAGTCAGGACGGACTGGGATGCGTTAAGTGTCCTGAAG
GAAGCTATTCCCAAGATGAGGAATGCATTCCTTGTCCTGTTGGATTCTACCAAGAACAGGCAGGGAGCTTGGCCTGTGTCCCATGTCCTG
TGGGCAGAACGACCATTTCTGCTGGAGCTTTCAGCCAGACTCACTGTGTCACTGACTGTCAGAGGAACGAAGCAGGCCTGCAATGTGACC
AGAATGGCCAGTATCGAGCCAGCCAGAAGGACAGGGGCAGTGGGAAGGCCTTCTGTGTGGACGGCGAGGGGCGGAGGCTGCCATGGTGGG
AAACAGAGGCCCCTCTTGAGGACTCACAGTGTTTGATGATGCAGAAGTTTGAGAAGGTTCCAGAATCAAAGGTGATCTTCGACGCCAATG
CTCCTGTGGCTGTCAGATCCAAAGTTCCTGATTCTGAGTTCCCCGTGATGCAGTGCTTGACAGATTGCACAGAGGACGAGGCCTGCAGCT
TCTTCACCGTGTCCACGACGGAGCCAGAGATTTCCTGTGATTTCTATGCTTGGACAAGTGACAATGTTGCCTGCATGACTTCTGACCAGA
AACGAGATGCACTGGGGAACTCAAAGGCCACCAGCTTTGGAAGTCTTCGCTGCCAGGTGAAAGTGAGGAGCCATGGTCAAGATTCTCCAG
CTGTGTATTTGAAAAAGGGCCAAGGATCCACCACAACACTTCAGAAACGCTTTGAACCCACTGGTTTCCAAAACATGCTTTCTGGATTGT
ACAACCCCATTGTGTTCTCAGCCTCAGGAGCCAATCTAACCGATGCTCACCTCTTCTGTCTTCTTGCATGCGACCGTGATCTGTGTTGCG
ATGGCTTCGTCCTCACACAGGTTCAAGGAGGTGCCATCATCTGTGGGTTGCTGAGCTCACCCAGTGTCCTGCTTTGTAATGTCAAAGACT
GGATGGATCCCTCTGAAGCCTGGGCTAATGCTACATGTCCTGGTGTGACATATGACCAGGAGAGCCACCAGGTGATATTGCGTCTTGGAG
ACCAGGAGTTCATCAAGAGTCTGACACCCTTAGAAGGAACTCAAGACACCTTTACCAATTTTCAGCAGGTTTATCTCTGGAAAGATTCTG
ACATGGGGTCTCGGCCTGAGTCTATGGGATGTAGAAAAGACACAGTGCCAAGGCCAGCATCTCCAACAGAAGCAGGTTTGACAACAGAAC
TTTTCTCCCCTGTGGACCTCAACCAGGTCATTGTCAATGGAAATCAATCACTATCCAGCCAGAAGCACTGGCTTTTCAAGCACCTGTTTT
CAGCCCAGCAGGCAAACCTATGGTGCCTTTCTCGTTGTGTGCAGGAGCACTCTTTCTGTCAGCTCGCAGAGATAACAGAGAGTGCATCCT
TGTACTTCACCTGCACCCTCTACCCAGAGGCACAGGTGTGTGATGACATCATGGAGTCCAATGCCCAGGGCTGCAGACTGATCCTGCCTC
AGATGCCAAAGGCCCTGTTCCGGAAGAAAGTTATACTGGAAGATAAAGTGAAGAACTTTTACACTCGCCTGCCGTTCCAAAAACTGATGG
GGATATCCATTAGAAATAAAGTGCCCATGTCTGAAAAATCTATTTCTAATGGGTTCTTTGAATGTGAACGACGGTGCGATGCGGACCCAT
GCTGCACTGGCTTTGGATTTCTAAATGTTTCCCAGTTAAAAGGAGGAGAGGTGACATGTCTCACTCTGAACAGCTTGGGAATTCAGATGT
GCAGTGAGGAGAATGGAGGAGCCTGGCGCATTTTGGACTGTGGCTCTCCTGACATTGAAGTCCACACCTATCCCTTCGGATGGTACCAGA
AGCCCATTGCTCAAAATAATGCTCCCAGTTTTTGCCCTTTGGTTGTTCTGCCTTCCCTCACAGAGAAAGTGTCTCTGGACTCGTGGCAGT
CCCTGGCCCTCTCTTCAGTGGTTGTTGATCCATCCATTAGGCACTTTGATGTTGCCCATGTCAGCACTGCTGCCACCAGCAATTTCTCTG
CTGTCCGAGACCTCTGTTTGTCGGAATGTTCCCAACATGAGGCCTGTCTCATCACCACTCTGCAAACCCAACCTGGGGCTGTGAGATGTA
TGTTCTATGCTGATACTCAAAGCTGCACACATAGTCTGCAGGGTCAGAACTGCCGACTTCTGCTTCGTGAAGAGGCCACCCACATCTACC
GGAAGCCAGGAATCTCTCTGCTCAGCTATGAGGCATCTGTACCTTCTGTGCCCATTTCCACCCATGGCCGGCTGCTGGGCAGGTCCCAGG
CCATCCAGGTGGGTACCTCATGGAAGCAAGTGGACCAGTTCCTTGGAGTTCCATATGCTGCCCCGCCCCTGGCAGAGAGGCGCTTCCAGG
CACCAGAGCCCTTGAACTGGACAGGCTCCTGGGATGCCAGCAAGCCAAGGGCCAGCTGCTGGCAGCCAGGCACCAGAACATCCACGTCTC
CTGGAGTCAGTGAAGATTGTTTGTATCTCAATGTGTTCATCCCTCAGAATGTGGCCCCTAACGCGTCTGTGCTGGTGTTCTTCCACAACA
CCATGGACAGGGAGGAGAGTGAAGGATGGCCGGCTATCGACGGCTCCTTCTTGGCTGCTGTTGGCAACCTCATCGTGGTCACTGCCAGCT
ACCGAGTGGGTGTCTTCGGCTTCCTGAGTTCTGGGTCCGGAGAGGTGAGTGGCAACTGGGGGCTGCTGGACCAGGTGGCGGCTCTGACCT
GGGTGCAGACCCACATCCGAGGATTTGGCGGGGACCCTCGGCGCGTGTCCCTGGCAGCAGACCGTGGCGGGGCTGATGTGGCCAGCATCC
ACCTTCTCACGGCCAGGGCCACCAACTCCCAACTTTTCCGGAGAGCTGTGCTGATGGGAGGCTCCGCACTCTCCCCGGCCGCCGTCATCA
GCCATGAGAGGGCTCAGCAGCAGGCAATTGCTTTGGCAAAGGAGGTCAGTTGCCCCATGTCATCCAGCCAAGAAGTGGTGTCCTGCCTCC
GCCAGAAGCCTGCCAATGTCCTCAATGATGCCCAGACCAAGCTCCTGGCCGTGAGTGGCCCTTTCCACTACTGGGGTCCTGTGATCGATG
GCCACTTCCTCCGTGAGCCTCCAGCCAGAGCACTGAAGAGGTCTTTATGGGTAGAGGTCGATCTGCTCATTGGGAGTTCTCAGGACGACG
GGCTCATCAACAGAGCAAAGGCTGTGAAGCAATTTGAGGAAAGTCGAGGCCGGACCAGTAGCAAAACAGCCTTTTACCAGGCACTGCAGA
ATTCTCTGGGTGGCGAGGACTCAGATGCCCGCGTCGAGGCTGCTGCTACATGGTATTACTCTCTGGAGCACTCCACGGATGACTATGCCT
CCTTCTCCCGGGCTCTGGAGAATGCCACCCGGGACTACTTTATCATCTGCCCTATAATCGACATGGCCAGTGCCTGGGCAAAGAGGGCCC
GAGGAAACGTCTTCATGTACCATGCTCCTGAAAACTACGGCCATGGCAGCCTGGAGCTGCTGGCGGATGTTCAGTTTGCCTTGGGGCTTC
CCTTCTACCCAGCCTACGAGGGGCAGTTTTCTCTGGAGGAGAAGAGCCTGTCGCTGAAAATCATGCAGTACTTTTCCCACTTCATCAGAT
CAGGAAATCCCAACTACCCTTATGAGTTCTCACGGAAAGTACCCACATTTGCAACCCCCTGGCCTGACTTTGTACCCCGTGCTGGTGGAG
AGAACTACAAGGAGTTCAGTGAGCTGCTCCCCAATCGACAGGGCCTGAAGAAAGCCGACTGCTCCTTCTGGTCCAAGTACATCTCGTCTC
TGAAGACATCTGCAGATGGAGCCAAGGGCGGGCAGTCAGCAGAGAGTGAAGAGGAGGAGTTGACGGCTGGATCTGGGCTAAGAGAAGATC
TCCTAAGCCTCCAGGAACCAGGCTCTAAGACCTACAGCAAGTGACCAGCCCTTGAGCTCCCCAAAAACCTCACCCGAGGCTGCCCACTAT

>79063_79063_1_SAMD12-TG_SAMD12_chr8_119592954_ENST00000314727_TG_chr8_133923622_ENST00000220616_length(amino acids)=1498AA_BP=64
MAVEALHCGLNPRGIDHPAHAEGIKLQIEGEGVESQSIKNKNFQKVPDQKGTPKRLQAEAETAKVKTFGTLVSIPVCNNSSVQVGCLTRE
RLGVNVTWKSRLEDIPVASLPDLHDIERALVGKDLLGRFTDLIQSGSFQLHLDSKTFPAETIRFLQGDHFGTSPRTWFGCSEGFYQVLTS
EASQDGLGCVKCPEGSYSQDEECIPCPVGFYQEQAGSLACVPCPVGRTTISAGAFSQTHCVTDCQRNEAGLQCDQNGQYRASQKDRGSGK
AFCVDGEGRRLPWWETEAPLEDSQCLMMQKFEKVPESKVIFDANAPVAVRSKVPDSEFPVMQCLTDCTEDEACSFFTVSTTEPEISCDFY
AWTSDNVACMTSDQKRDALGNSKATSFGSLRCQVKVRSHGQDSPAVYLKKGQGSTTTLQKRFEPTGFQNMLSGLYNPIVFSASGANLTDA
HLFCLLACDRDLCCDGFVLTQVQGGAIICGLLSSPSVLLCNVKDWMDPSEAWANATCPGVTYDQESHQVILRLGDQEFIKSLTPLEGTQD
TFTNFQQVYLWKDSDMGSRPESMGCRKDTVPRPASPTEAGLTTELFSPVDLNQVIVNGNQSLSSQKHWLFKHLFSAQQANLWCLSRCVQE
HSFCQLAEITESASLYFTCTLYPEAQVCDDIMESNAQGCRLILPQMPKALFRKKVILEDKVKNFYTRLPFQKLMGISIRNKVPMSEKSIS
NGFFECERRCDADPCCTGFGFLNVSQLKGGEVTCLTLNSLGIQMCSEENGGAWRILDCGSPDIEVHTYPFGWYQKPIAQNNAPSFCPLVV
LPSLTEKVSLDSWQSLALSSVVVDPSIRHFDVAHVSTAATSNFSAVRDLCLSECSQHEACLITTLQTQPGAVRCMFYADTQSCTHSLQGQ
NCRLLLREEATHIYRKPGISLLSYEASVPSVPISTHGRLLGRSQAIQVGTSWKQVDQFLGVPYAAPPLAERRFQAPEPLNWTGSWDASKP
RASCWQPGTRTSTSPGVSEDCLYLNVFIPQNVAPNASVLVFFHNTMDREESEGWPAIDGSFLAAVGNLIVVTASYRVGVFGFLSSGSGEV
SGNWGLLDQVAALTWVQTHIRGFGGDPRRVSLAADRGGADVASIHLLTARATNSQLFRRAVLMGGSALSPAAVISHERAQQQAIALAKEV
SCPMSSSQEVVSCLRQKPANVLNDAQTKLLAVSGPFHYWGPVIDGHFLREPPARALKRSLWVEVDLLIGSSQDDGLINRAKAVKQFEESR
GRTSSKTAFYQALQNSLGGEDSDARVEAAATWYYSLEHSTDDYASFSRALENATRDYFIICPIIDMASAWAKRARGNVFMYHAPENYGHG
SLELLADVQFALGLPFYPAYEGQFSLEEKSLSLKIMQYFSHFIRSGNPNYPYEFSRKVPTFATPWPDFVPRAGGENYKEFSELLPNRQGL

--------------------------------------------------------------
>79063_79063_2_SAMD12-TG_SAMD12_chr8_119592954_ENST00000314727_TG_chr8_133923622_ENST00000377869_length(transcript)=4568nt_BP=329nt
GCGTGACCGCGGCAGGTTGGTCCTGGAGCAGATAAGCGCAGAATATTTAGGCGAAAGCGAGAGGAAGGGGGGAGCGCGGGGCAGGAGGAG
TACCTCGGCCAAGAAAATTATGCATGCGTTAGGGAAGCTCTGAGAGAATGGCTGTGGAAGCTCTCCACTGTGGTTTGAATCCACGGGGTA
TTGATCACCCTGCCCATGCTGAAGGTATTAAACTGCAAATTGAAGGTGAAGGTGTGGAATCTCAATCCATTAAAAATAAAAATTTCCAGA
AGGTGCCTGACCAGAAAGGAACTCCCAAGCGACTGCAGGCAGAAGCTGAGACGGCTAAGGTGAAGACTTTTGGCACCCTGGTTTCCATTC
CTGTCTGCAACAACTCCTCTGTGCAGGTGGGTTGTCTGACCAGGGAGCGTTTAGGAGTGAATGTTACATGGAAATCACGGCTTGAGGACA
TCCCAGTGGCTTCTCTTCCTGACTTACATGACATTGAGAGAGCCTTGGTGGGCAAGGATCTCCTTGGGCGCTTCACAGATCTGATCCAGA
GTGGCTCATTCCAGCTTCATCTGGACTCCAAGACGTTCCCAGCGGAAACCATCCGCTTCCTCCAAGGGGACCACTTTGGCACCTCTCCCA
GGACATGGTTTGGGTGCTCGGAAGGATTCTACCAAGTCTTGACAAGTGAGGCCAGTCAGGACGGACTGGGATGCGTTAAGTGTCCTGAAG
GAAGCTATTCCCAAGATGAGGAATGCATTCCTTGTCCTGTTGGATTCTACCAAGAACAGGCAGGGAGCTTGGCCTGTGTCCCATGTCCTG
TGGGCAGAACGACCATTTCTGCTGGAGCTTTCAGCCAGACTCACTTGATGCAGAAGTTTGAGAAGGTTCCAGAATCAAAGGTGATCTTCG
ACGCCAATGCTCCTGTGGCTGTCAGATCCAAAGTTCCTGATTCTGAGTTCCCCGTGATGCAGTGCTTGACAGATTGCACAGAGGACGAGG
CCTGCAGCTTCTTCACCGTGTCCACGACGGAGCCAGAGATTTCCTGTGATTTCTATGCTTGGACAAGTGACAATGTTGCCTGCATGACTT
CTGACCAGAAACGAGATGCACTGGGGAACTCAAAGGCCACCAGCTTTGGAAGTCTTCGCTGCCAGGTGAAAGTGAGGAGCCATGGTCAAG
ATTCTCCAGCTGTGTATTTGAAAAAGGGCCAAGGATCCACCACAACACTTCAGAAACGCTTTGAACCCACTGGTTTCCAAAACATGCTTT
CTGGATTGTACAACCCCATTGTGTTCTCAGCCTCAGGAGCCAATCTAACCGATGCTCACCTCTTCTGTCTTCTTGCATGCGACCGTGATC
TGTGTTGCGATGGCTTCGTCCTCACACAGGTTCAAGGAGGTGCCATCATCTGTGGGTTGCTGAGCTCACCCAGTGTCCTGCTTTGTAATG
TCAAAGACTGGATGGATCCCTCTGAAGCCTGGGCTAATGCTACATGTCCTGGTGTGACATATGACCAGGAGAGCCACCAGGTGATATTGC
GTCTTGGAGACCAGGAGTTCATCAAGAGTCTGACACCCTTAGAAGGAACTCAAGACACCTTTACCAATTTTCAGCAGGTTTATCTCTGGA
AAGATTCTGACATGGGGTCTCGGCCTGAGTCTATGGGATGTAGAAAAGACACAGTGCCAAGGCCAGCATCTCCAACAGAAGCAGGTTTGA
CAACAGAACTTTTCTCCCCTGTGGACCTCAACCAGGTCATTGTCAATGGAAATCAATCACTATCCAGCCAGAAGCACTGGCTTTTCAAGC
ACCTGTTTTCAGCCCAGCAGGCAAACCTATGGTGCCTTTCTCGTTGTGTGCAGGAGCACTCTTTCTGTCAGCTCGCAGAGATAACAGAGA
GTGCATCCTTGTACTTCACCTGCACCCTCTACCCAGAGGCACAGGTGTGTGATGACATCATGGAGTCCAATGCCCAGGGCTGCAGACTGA
TCCTGCCTCAGATGCCAAAGGCCCTGTTCCGGAAGAAAGTTATACTGGAAGATAAAGTGAAGAACTTTTACACTCGCCTGCCGTTCCAAA
AACTGATGGGGATATCCATTAGAAATAAAGTGCCCATGTCTGAAAAATCTATTTCTAATGGGTTCTTTGAATGTGAACGACGGTGCGATG
CGGACCCATGCTGCACTGGCTTTGGATTTCTAAATGTTTCCCAGTTAAAAGGAGGAGAGGTGACATGTCTCACTCTGAACAGCTTGGGAA
TTCAGATGTGCAGTGAGGAGAATGGAGGAGCCTGGCGCATTTTGGACTGTGGCTCTCCTGACATTGAAGTCCACACCTATCCCTTCGGAT
GGTACCAGAAGCCCATTGCTCAAAATAATGCTCCCAGTTTTTGCCCTTTGGTTGTTCTGCCTTCCCTCACAGAGAAAGTGTCTCTGGACT
CGTGGCAGTCCCTGGCCCTCTCTTCAGTGGTTGTTGATCCATCCATTAGGCACTTTGATGTTGCCCATGTCAGCACTGCTGCCACCAGCA
ATTTCTCTGCTGTCCGAGACCTCTGTTTGTCGGAATGTTCCCAACATGAGGCCTGTCTCATCACCACTCTGCAAACCCAACCTGGGGCTG
TGAGATGTATGTTCTATGCTGATACTCAAAGCTGCACACATAGTCTGCAGGGTCAGAACTGCCGACTTCTGCTTCGTGAAGAGGCCACCC
ACATCTACCGGAAGCCAGGAATCTCTCTGCTCAGCTATGAGGCATCTGTACCTTCTGTGCCCATTTCCACCCATGGCCGGCTGCTGGGCA
GGTCCCAGGCCATCCAGGTGGGTACCTCATGGAAGCAAGTGGACCAGTTCCTTGGAGTTCCATATGCTGCCCCGCCCCTGGCAGAGAGGC
GCTTCCAGGCACCAGAGCCCTTGAACTGGACAGGCTCCTGGGATGCCAGCAAGCCAAGGGCCAGCTGCTGGCAGCCAGGCACCAGAACAT
CCACGTCTCCTGGAGTCAGTGAAGATTGTTTGTATCTCAATGTGTTCATCCCTCAGAATGTGGCCCCTAACGCGTCTGTGCTGGTGTTCT
TCCACAACACCATGGACAGGGAGGAGAGTGAAGGATGGCCGGCTATCGACGGCTCCTTCTTGGCTGCTGTTGGCAACCTCATCGTGGTCA
CTGCCAGCTACCGAGTGGGTGTCTTCGGCTTCCTGAGTTCTGGGTCCGGAGAGGTGAGTGGCAACTGGGGGCTGCTGGACCAGGTGGCGG
CTCTGACCTGGGTGCAGACCCACATCCGAGGATTTGGCGGGGACCCTCGGCGCGTGTCCCTGGCAGCAGACCGTGGCGGGGCTGATGTGG
CCAGCATCCACCTTCTCACGGCCAGGGCCACCAACTCCCAACTTTTCCGGAGAGCTGTGCTGATGGGAGGCTCCGCACTCTCCCCGGCCG
CCGTCATCAGCCATGAGAGGGCTCAGCAGCAGGCAATTGCTTTGGCAAAGGAGGTCAGTTGCCCCATGTCATCCAGCCAAGAAGTGGTGT
CCTGCCTCCGCCAGAAGCCTGCCAATGTCCTCAATGATGCCCAGACCAAGCTCCTGGCCGTGAGTGGCCCTTTCCACTACTGGGGTCCTG
TGATCGATGGCCACTTCCTCCGTGAGCCTCCAGCCAGAGCACTGAAGAGGTCTTTATGGGTAGAGGTCGATCTGCTCATTGGGAGTTCTC
AGGACGACGGGCTCATCAACAGAGCAAAGGCTGTGAAGCAATTTGAGGAAAGTCGAGGCCGGACCAGTAGCAAAACAGCCTTTTACCAGG
CACTGCAGAATTCTCTGGGTGGCGAGGACTCAGATGCCCGCGTCGAGGCTGCTGCTACATGGTATTACTCTCTGGAGCACTCCACGGATG
ACTATGCCTCCTTCTCCCGGGCTCTGGAGAATGCCACCCGGGACTACTTTATCATCTGCCCTATAATCGACATGGCCAGTGCCTGGGCAA
AGAGGGCCCGAGGAAACGTCTTCATGTACCATGCTCCTGAAAACTACGGCCATGGCAGCCTGGAGCTGCTGGCGGATGTTCAGTTTGCCT
TGGGGCTTCCCTTCTACCCAGCCTACGAGGGGCAGTTTTCTCTGGAGGAGAAGAGCCTGTCGCTGAAAATCATGCAGTACTTTTCCCACT
TCATCAGATCAGGAAATCCCAACTACCCTTATGAGTTCTCACGGAAAGTACCCACATTTGCAACCCCCTGGCCTGACTTTGTACCCCGTG
CTGGTGGAGAGAACTACAAGGAGTTCAGTGAGCTGCTCCCCAATCGACAGGGCCTGAAGAAAGCCGACTGCTCCTTCTGGTCCAAGTACA
TCTCGTCTCTGAAGACATCTGCAGATGGAGCCAAGGGCGGGCAGTCAGCAGAGAGTGAAGAGGAGGAGTTGACGGCTGGATCTGGGCTAA
GAGAAGATCTCCTAAGCCTCCAGGAACCAGGCTCTAAGACCTACAGCAAGTGACCAGCCCTTGAGCTCCCCAAAAACCTCACCCGAGGCT

>79063_79063_2_SAMD12-TG_SAMD12_chr8_119592954_ENST00000314727_TG_chr8_133923622_ENST00000377869_length(amino acids)=1441AA_BP=64
MAVEALHCGLNPRGIDHPAHAEGIKLQIEGEGVESQSIKNKNFQKVPDQKGTPKRLQAEAETAKVKTFGTLVSIPVCNNSSVQVGCLTRE
RLGVNVTWKSRLEDIPVASLPDLHDIERALVGKDLLGRFTDLIQSGSFQLHLDSKTFPAETIRFLQGDHFGTSPRTWFGCSEGFYQVLTS
EASQDGLGCVKCPEGSYSQDEECIPCPVGFYQEQAGSLACVPCPVGRTTISAGAFSQTHLMQKFEKVPESKVIFDANAPVAVRSKVPDSE
FPVMQCLTDCTEDEACSFFTVSTTEPEISCDFYAWTSDNVACMTSDQKRDALGNSKATSFGSLRCQVKVRSHGQDSPAVYLKKGQGSTTT
LQKRFEPTGFQNMLSGLYNPIVFSASGANLTDAHLFCLLACDRDLCCDGFVLTQVQGGAIICGLLSSPSVLLCNVKDWMDPSEAWANATC
PGVTYDQESHQVILRLGDQEFIKSLTPLEGTQDTFTNFQQVYLWKDSDMGSRPESMGCRKDTVPRPASPTEAGLTTELFSPVDLNQVIVN
GNQSLSSQKHWLFKHLFSAQQANLWCLSRCVQEHSFCQLAEITESASLYFTCTLYPEAQVCDDIMESNAQGCRLILPQMPKALFRKKVIL
EDKVKNFYTRLPFQKLMGISIRNKVPMSEKSISNGFFECERRCDADPCCTGFGFLNVSQLKGGEVTCLTLNSLGIQMCSEENGGAWRILD
CGSPDIEVHTYPFGWYQKPIAQNNAPSFCPLVVLPSLTEKVSLDSWQSLALSSVVVDPSIRHFDVAHVSTAATSNFSAVRDLCLSECSQH
EACLITTLQTQPGAVRCMFYADTQSCTHSLQGQNCRLLLREEATHIYRKPGISLLSYEASVPSVPISTHGRLLGRSQAIQVGTSWKQVDQ
FLGVPYAAPPLAERRFQAPEPLNWTGSWDASKPRASCWQPGTRTSTSPGVSEDCLYLNVFIPQNVAPNASVLVFFHNTMDREESEGWPAI
DGSFLAAVGNLIVVTASYRVGVFGFLSSGSGEVSGNWGLLDQVAALTWVQTHIRGFGGDPRRVSLAADRGGADVASIHLLTARATNSQLF
RRAVLMGGSALSPAAVISHERAQQQAIALAKEVSCPMSSSQEVVSCLRQKPANVLNDAQTKLLAVSGPFHYWGPVIDGHFLREPPARALK
RSLWVEVDLLIGSSQDDGLINRAKAVKQFEESRGRTSSKTAFYQALQNSLGGEDSDARVEAAATWYYSLEHSTDDYASFSRALENATRDY
FIICPIIDMASAWAKRARGNVFMYHAPENYGHGSLELLADVQFALGLPFYPAYEGQFSLEEKSLSLKIMQYFSHFIRSGNPNYPYEFSRK
VPTFATPWPDFVPRAGGENYKEFSELLPNRQGLKKADCSFWSKYISSLKTSADGAKGGQSAESEEEELTAGSGLREDLLSLQEPGSKTYS

--------------------------------------------------------------
>79063_79063_3_SAMD12-TG_SAMD12_chr8_119592954_ENST00000409003_TG_chr8_133923622_ENST00000220616_length(transcript)=4729nt_BP=321nt
GCGGCAGGTTGGTCCTGGAGCAGATAAGCGCAGAATATTTAGGCGAAAGCGAGAGGAAGGGGGGAGCGCGGGGCAGGAGGAGTACCTCGG
CCAAGAAAATTATGCATGCGTTAGGGAAGCTCTGAGAGAATGGCTGTGGAAGCTCTCCACTGTGGTTTGAATCCACGGGGTATTGATCAC
CCTGCCCATGCTGAAGGTATTAAACTGCAAATTGAAGGTGAAGGTGTGGAATCTCAATCCATTAAAAATAAAAATTTCCAGAAGGTGCCT
GACCAGAAAGGAACTCCCAAGCGACTGCAGGCAGAAGCTGAGACGGCTAAGGTGAAGACTTTTGGCACCCTGGTTTCCATTCCTGTCTGC
AACAACTCCTCTGTGCAGGTGGGTTGTCTGACCAGGGAGCGTTTAGGAGTGAATGTTACATGGAAATCACGGCTTGAGGACATCCCAGTG
GCTTCTCTTCCTGACTTACATGACATTGAGAGAGCCTTGGTGGGCAAGGATCTCCTTGGGCGCTTCACAGATCTGATCCAGAGTGGCTCA
TTCCAGCTTCATCTGGACTCCAAGACGTTCCCAGCGGAAACCATCCGCTTCCTCCAAGGGGACCACTTTGGCACCTCTCCCAGGACATGG
TTTGGGTGCTCGGAAGGATTCTACCAAGTCTTGACAAGTGAGGCCAGTCAGGACGGACTGGGATGCGTTAAGTGTCCTGAAGGAAGCTAT
TCCCAAGATGAGGAATGCATTCCTTGTCCTGTTGGATTCTACCAAGAACAGGCAGGGAGCTTGGCCTGTGTCCCATGTCCTGTGGGCAGA
ACGACCATTTCTGCTGGAGCTTTCAGCCAGACTCACTGTGTCACTGACTGTCAGAGGAACGAAGCAGGCCTGCAATGTGACCAGAATGGC
CAGTATCGAGCCAGCCAGAAGGACAGGGGCAGTGGGAAGGCCTTCTGTGTGGACGGCGAGGGGCGGAGGCTGCCATGGTGGGAAACAGAG
GCCCCTCTTGAGGACTCACAGTGTTTGATGATGCAGAAGTTTGAGAAGGTTCCAGAATCAAAGGTGATCTTCGACGCCAATGCTCCTGTG
GCTGTCAGATCCAAAGTTCCTGATTCTGAGTTCCCCGTGATGCAGTGCTTGACAGATTGCACAGAGGACGAGGCCTGCAGCTTCTTCACC
GTGTCCACGACGGAGCCAGAGATTTCCTGTGATTTCTATGCTTGGACAAGTGACAATGTTGCCTGCATGACTTCTGACCAGAAACGAGAT
GCACTGGGGAACTCAAAGGCCACCAGCTTTGGAAGTCTTCGCTGCCAGGTGAAAGTGAGGAGCCATGGTCAAGATTCTCCAGCTGTGTAT
TTGAAAAAGGGCCAAGGATCCACCACAACACTTCAGAAACGCTTTGAACCCACTGGTTTCCAAAACATGCTTTCTGGATTGTACAACCCC
ATTGTGTTCTCAGCCTCAGGAGCCAATCTAACCGATGCTCACCTCTTCTGTCTTCTTGCATGCGACCGTGATCTGTGTTGCGATGGCTTC
GTCCTCACACAGGTTCAAGGAGGTGCCATCATCTGTGGGTTGCTGAGCTCACCCAGTGTCCTGCTTTGTAATGTCAAAGACTGGATGGAT
CCCTCTGAAGCCTGGGCTAATGCTACATGTCCTGGTGTGACATATGACCAGGAGAGCCACCAGGTGATATTGCGTCTTGGAGACCAGGAG
TTCATCAAGAGTCTGACACCCTTAGAAGGAACTCAAGACACCTTTACCAATTTTCAGCAGGTTTATCTCTGGAAAGATTCTGACATGGGG
TCTCGGCCTGAGTCTATGGGATGTAGAAAAGACACAGTGCCAAGGCCAGCATCTCCAACAGAAGCAGGTTTGACAACAGAACTTTTCTCC
CCTGTGGACCTCAACCAGGTCATTGTCAATGGAAATCAATCACTATCCAGCCAGAAGCACTGGCTTTTCAAGCACCTGTTTTCAGCCCAG
CAGGCAAACCTATGGTGCCTTTCTCGTTGTGTGCAGGAGCACTCTTTCTGTCAGCTCGCAGAGATAACAGAGAGTGCATCCTTGTACTTC
ACCTGCACCCTCTACCCAGAGGCACAGGTGTGTGATGACATCATGGAGTCCAATGCCCAGGGCTGCAGACTGATCCTGCCTCAGATGCCA
AAGGCCCTGTTCCGGAAGAAAGTTATACTGGAAGATAAAGTGAAGAACTTTTACACTCGCCTGCCGTTCCAAAAACTGATGGGGATATCC
ATTAGAAATAAAGTGCCCATGTCTGAAAAATCTATTTCTAATGGGTTCTTTGAATGTGAACGACGGTGCGATGCGGACCCATGCTGCACT
GGCTTTGGATTTCTAAATGTTTCCCAGTTAAAAGGAGGAGAGGTGACATGTCTCACTCTGAACAGCTTGGGAATTCAGATGTGCAGTGAG
GAGAATGGAGGAGCCTGGCGCATTTTGGACTGTGGCTCTCCTGACATTGAAGTCCACACCTATCCCTTCGGATGGTACCAGAAGCCCATT
GCTCAAAATAATGCTCCCAGTTTTTGCCCTTTGGTTGTTCTGCCTTCCCTCACAGAGAAAGTGTCTCTGGACTCGTGGCAGTCCCTGGCC
CTCTCTTCAGTGGTTGTTGATCCATCCATTAGGCACTTTGATGTTGCCCATGTCAGCACTGCTGCCACCAGCAATTTCTCTGCTGTCCGA
GACCTCTGTTTGTCGGAATGTTCCCAACATGAGGCCTGTCTCATCACCACTCTGCAAACCCAACCTGGGGCTGTGAGATGTATGTTCTAT
GCTGATACTCAAAGCTGCACACATAGTCTGCAGGGTCAGAACTGCCGACTTCTGCTTCGTGAAGAGGCCACCCACATCTACCGGAAGCCA
GGAATCTCTCTGCTCAGCTATGAGGCATCTGTACCTTCTGTGCCCATTTCCACCCATGGCCGGCTGCTGGGCAGGTCCCAGGCCATCCAG
GTGGGTACCTCATGGAAGCAAGTGGACCAGTTCCTTGGAGTTCCATATGCTGCCCCGCCCCTGGCAGAGAGGCGCTTCCAGGCACCAGAG
CCCTTGAACTGGACAGGCTCCTGGGATGCCAGCAAGCCAAGGGCCAGCTGCTGGCAGCCAGGCACCAGAACATCCACGTCTCCTGGAGTC
AGTGAAGATTGTTTGTATCTCAATGTGTTCATCCCTCAGAATGTGGCCCCTAACGCGTCTGTGCTGGTGTTCTTCCACAACACCATGGAC
AGGGAGGAGAGTGAAGGATGGCCGGCTATCGACGGCTCCTTCTTGGCTGCTGTTGGCAACCTCATCGTGGTCACTGCCAGCTACCGAGTG
GGTGTCTTCGGCTTCCTGAGTTCTGGGTCCGGAGAGGTGAGTGGCAACTGGGGGCTGCTGGACCAGGTGGCGGCTCTGACCTGGGTGCAG
ACCCACATCCGAGGATTTGGCGGGGACCCTCGGCGCGTGTCCCTGGCAGCAGACCGTGGCGGGGCTGATGTGGCCAGCATCCACCTTCTC
ACGGCCAGGGCCACCAACTCCCAACTTTTCCGGAGAGCTGTGCTGATGGGAGGCTCCGCACTCTCCCCGGCCGCCGTCATCAGCCATGAG
AGGGCTCAGCAGCAGGCAATTGCTTTGGCAAAGGAGGTCAGTTGCCCCATGTCATCCAGCCAAGAAGTGGTGTCCTGCCTCCGCCAGAAG
CCTGCCAATGTCCTCAATGATGCCCAGACCAAGCTCCTGGCCGTGAGTGGCCCTTTCCACTACTGGGGTCCTGTGATCGATGGCCACTTC
CTCCGTGAGCCTCCAGCCAGAGCACTGAAGAGGTCTTTATGGGTAGAGGTCGATCTGCTCATTGGGAGTTCTCAGGACGACGGGCTCATC
AACAGAGCAAAGGCTGTGAAGCAATTTGAGGAAAGTCGAGGCCGGACCAGTAGCAAAACAGCCTTTTACCAGGCACTGCAGAATTCTCTG
GGTGGCGAGGACTCAGATGCCCGCGTCGAGGCTGCTGCTACATGGTATTACTCTCTGGAGCACTCCACGGATGACTATGCCTCCTTCTCC
CGGGCTCTGGAGAATGCCACCCGGGACTACTTTATCATCTGCCCTATAATCGACATGGCCAGTGCCTGGGCAAAGAGGGCCCGAGGAAAC
GTCTTCATGTACCATGCTCCTGAAAACTACGGCCATGGCAGCCTGGAGCTGCTGGCGGATGTTCAGTTTGCCTTGGGGCTTCCCTTCTAC
CCAGCCTACGAGGGGCAGTTTTCTCTGGAGGAGAAGAGCCTGTCGCTGAAAATCATGCAGTACTTTTCCCACTTCATCAGATCAGGAAAT
CCCAACTACCCTTATGAGTTCTCACGGAAAGTACCCACATTTGCAACCCCCTGGCCTGACTTTGTACCCCGTGCTGGTGGAGAGAACTAC
AAGGAGTTCAGTGAGCTGCTCCCCAATCGACAGGGCCTGAAGAAAGCCGACTGCTCCTTCTGGTCCAAGTACATCTCGTCTCTGAAGACA
TCTGCAGATGGAGCCAAGGGCGGGCAGTCAGCAGAGAGTGAAGAGGAGGAGTTGACGGCTGGATCTGGGCTAAGAGAAGATCTCCTAAGC
CTCCAGGAACCAGGCTCTAAGACCTACAGCAAGTGACCAGCCCTTGAGCTCCCCAAAAACCTCACCCGAGGCTGCCCACTATGGTCATCT

>79063_79063_3_SAMD12-TG_SAMD12_chr8_119592954_ENST00000409003_TG_chr8_133923622_ENST00000220616_length(amino acids)=1498AA_BP=64
MAVEALHCGLNPRGIDHPAHAEGIKLQIEGEGVESQSIKNKNFQKVPDQKGTPKRLQAEAETAKVKTFGTLVSIPVCNNSSVQVGCLTRE
RLGVNVTWKSRLEDIPVASLPDLHDIERALVGKDLLGRFTDLIQSGSFQLHLDSKTFPAETIRFLQGDHFGTSPRTWFGCSEGFYQVLTS
EASQDGLGCVKCPEGSYSQDEECIPCPVGFYQEQAGSLACVPCPVGRTTISAGAFSQTHCVTDCQRNEAGLQCDQNGQYRASQKDRGSGK
AFCVDGEGRRLPWWETEAPLEDSQCLMMQKFEKVPESKVIFDANAPVAVRSKVPDSEFPVMQCLTDCTEDEACSFFTVSTTEPEISCDFY
AWTSDNVACMTSDQKRDALGNSKATSFGSLRCQVKVRSHGQDSPAVYLKKGQGSTTTLQKRFEPTGFQNMLSGLYNPIVFSASGANLTDA
HLFCLLACDRDLCCDGFVLTQVQGGAIICGLLSSPSVLLCNVKDWMDPSEAWANATCPGVTYDQESHQVILRLGDQEFIKSLTPLEGTQD
TFTNFQQVYLWKDSDMGSRPESMGCRKDTVPRPASPTEAGLTTELFSPVDLNQVIVNGNQSLSSQKHWLFKHLFSAQQANLWCLSRCVQE
HSFCQLAEITESASLYFTCTLYPEAQVCDDIMESNAQGCRLILPQMPKALFRKKVILEDKVKNFYTRLPFQKLMGISIRNKVPMSEKSIS
NGFFECERRCDADPCCTGFGFLNVSQLKGGEVTCLTLNSLGIQMCSEENGGAWRILDCGSPDIEVHTYPFGWYQKPIAQNNAPSFCPLVV
LPSLTEKVSLDSWQSLALSSVVVDPSIRHFDVAHVSTAATSNFSAVRDLCLSECSQHEACLITTLQTQPGAVRCMFYADTQSCTHSLQGQ
NCRLLLREEATHIYRKPGISLLSYEASVPSVPISTHGRLLGRSQAIQVGTSWKQVDQFLGVPYAAPPLAERRFQAPEPLNWTGSWDASKP
RASCWQPGTRTSTSPGVSEDCLYLNVFIPQNVAPNASVLVFFHNTMDREESEGWPAIDGSFLAAVGNLIVVTASYRVGVFGFLSSGSGEV
SGNWGLLDQVAALTWVQTHIRGFGGDPRRVSLAADRGGADVASIHLLTARATNSQLFRRAVLMGGSALSPAAVISHERAQQQAIALAKEV
SCPMSSSQEVVSCLRQKPANVLNDAQTKLLAVSGPFHYWGPVIDGHFLREPPARALKRSLWVEVDLLIGSSQDDGLINRAKAVKQFEESR
GRTSSKTAFYQALQNSLGGEDSDARVEAAATWYYSLEHSTDDYASFSRALENATRDYFIICPIIDMASAWAKRARGNVFMYHAPENYGHG
SLELLADVQFALGLPFYPAYEGQFSLEEKSLSLKIMQYFSHFIRSGNPNYPYEFSRKVPTFATPWPDFVPRAGGENYKEFSELLPNRQGL

--------------------------------------------------------------
>79063_79063_4_SAMD12-TG_SAMD12_chr8_119592954_ENST00000409003_TG_chr8_133923622_ENST00000377869_length(transcript)=4560nt_BP=321nt
GCGGCAGGTTGGTCCTGGAGCAGATAAGCGCAGAATATTTAGGCGAAAGCGAGAGGAAGGGGGGAGCGCGGGGCAGGAGGAGTACCTCGG
CCAAGAAAATTATGCATGCGTTAGGGAAGCTCTGAGAGAATGGCTGTGGAAGCTCTCCACTGTGGTTTGAATCCACGGGGTATTGATCAC
CCTGCCCATGCTGAAGGTATTAAACTGCAAATTGAAGGTGAAGGTGTGGAATCTCAATCCATTAAAAATAAAAATTTCCAGAAGGTGCCT
GACCAGAAAGGAACTCCCAAGCGACTGCAGGCAGAAGCTGAGACGGCTAAGGTGAAGACTTTTGGCACCCTGGTTTCCATTCCTGTCTGC
AACAACTCCTCTGTGCAGGTGGGTTGTCTGACCAGGGAGCGTTTAGGAGTGAATGTTACATGGAAATCACGGCTTGAGGACATCCCAGTG
GCTTCTCTTCCTGACTTACATGACATTGAGAGAGCCTTGGTGGGCAAGGATCTCCTTGGGCGCTTCACAGATCTGATCCAGAGTGGCTCA
TTCCAGCTTCATCTGGACTCCAAGACGTTCCCAGCGGAAACCATCCGCTTCCTCCAAGGGGACCACTTTGGCACCTCTCCCAGGACATGG
TTTGGGTGCTCGGAAGGATTCTACCAAGTCTTGACAAGTGAGGCCAGTCAGGACGGACTGGGATGCGTTAAGTGTCCTGAAGGAAGCTAT
TCCCAAGATGAGGAATGCATTCCTTGTCCTGTTGGATTCTACCAAGAACAGGCAGGGAGCTTGGCCTGTGTCCCATGTCCTGTGGGCAGA
ACGACCATTTCTGCTGGAGCTTTCAGCCAGACTCACTTGATGCAGAAGTTTGAGAAGGTTCCAGAATCAAAGGTGATCTTCGACGCCAAT
GCTCCTGTGGCTGTCAGATCCAAAGTTCCTGATTCTGAGTTCCCCGTGATGCAGTGCTTGACAGATTGCACAGAGGACGAGGCCTGCAGC
TTCTTCACCGTGTCCACGACGGAGCCAGAGATTTCCTGTGATTTCTATGCTTGGACAAGTGACAATGTTGCCTGCATGACTTCTGACCAG
AAACGAGATGCACTGGGGAACTCAAAGGCCACCAGCTTTGGAAGTCTTCGCTGCCAGGTGAAAGTGAGGAGCCATGGTCAAGATTCTCCA
GCTGTGTATTTGAAAAAGGGCCAAGGATCCACCACAACACTTCAGAAACGCTTTGAACCCACTGGTTTCCAAAACATGCTTTCTGGATTG
TACAACCCCATTGTGTTCTCAGCCTCAGGAGCCAATCTAACCGATGCTCACCTCTTCTGTCTTCTTGCATGCGACCGTGATCTGTGTTGC
GATGGCTTCGTCCTCACACAGGTTCAAGGAGGTGCCATCATCTGTGGGTTGCTGAGCTCACCCAGTGTCCTGCTTTGTAATGTCAAAGAC
TGGATGGATCCCTCTGAAGCCTGGGCTAATGCTACATGTCCTGGTGTGACATATGACCAGGAGAGCCACCAGGTGATATTGCGTCTTGGA
GACCAGGAGTTCATCAAGAGTCTGACACCCTTAGAAGGAACTCAAGACACCTTTACCAATTTTCAGCAGGTTTATCTCTGGAAAGATTCT
GACATGGGGTCTCGGCCTGAGTCTATGGGATGTAGAAAAGACACAGTGCCAAGGCCAGCATCTCCAACAGAAGCAGGTTTGACAACAGAA
CTTTTCTCCCCTGTGGACCTCAACCAGGTCATTGTCAATGGAAATCAATCACTATCCAGCCAGAAGCACTGGCTTTTCAAGCACCTGTTT
TCAGCCCAGCAGGCAAACCTATGGTGCCTTTCTCGTTGTGTGCAGGAGCACTCTTTCTGTCAGCTCGCAGAGATAACAGAGAGTGCATCC
TTGTACTTCACCTGCACCCTCTACCCAGAGGCACAGGTGTGTGATGACATCATGGAGTCCAATGCCCAGGGCTGCAGACTGATCCTGCCT
CAGATGCCAAAGGCCCTGTTCCGGAAGAAAGTTATACTGGAAGATAAAGTGAAGAACTTTTACACTCGCCTGCCGTTCCAAAAACTGATG
GGGATATCCATTAGAAATAAAGTGCCCATGTCTGAAAAATCTATTTCTAATGGGTTCTTTGAATGTGAACGACGGTGCGATGCGGACCCA
TGCTGCACTGGCTTTGGATTTCTAAATGTTTCCCAGTTAAAAGGAGGAGAGGTGACATGTCTCACTCTGAACAGCTTGGGAATTCAGATG
TGCAGTGAGGAGAATGGAGGAGCCTGGCGCATTTTGGACTGTGGCTCTCCTGACATTGAAGTCCACACCTATCCCTTCGGATGGTACCAG
AAGCCCATTGCTCAAAATAATGCTCCCAGTTTTTGCCCTTTGGTTGTTCTGCCTTCCCTCACAGAGAAAGTGTCTCTGGACTCGTGGCAG
TCCCTGGCCCTCTCTTCAGTGGTTGTTGATCCATCCATTAGGCACTTTGATGTTGCCCATGTCAGCACTGCTGCCACCAGCAATTTCTCT
GCTGTCCGAGACCTCTGTTTGTCGGAATGTTCCCAACATGAGGCCTGTCTCATCACCACTCTGCAAACCCAACCTGGGGCTGTGAGATGT
ATGTTCTATGCTGATACTCAAAGCTGCACACATAGTCTGCAGGGTCAGAACTGCCGACTTCTGCTTCGTGAAGAGGCCACCCACATCTAC
CGGAAGCCAGGAATCTCTCTGCTCAGCTATGAGGCATCTGTACCTTCTGTGCCCATTTCCACCCATGGCCGGCTGCTGGGCAGGTCCCAG
GCCATCCAGGTGGGTACCTCATGGAAGCAAGTGGACCAGTTCCTTGGAGTTCCATATGCTGCCCCGCCCCTGGCAGAGAGGCGCTTCCAG
GCACCAGAGCCCTTGAACTGGACAGGCTCCTGGGATGCCAGCAAGCCAAGGGCCAGCTGCTGGCAGCCAGGCACCAGAACATCCACGTCT
CCTGGAGTCAGTGAAGATTGTTTGTATCTCAATGTGTTCATCCCTCAGAATGTGGCCCCTAACGCGTCTGTGCTGGTGTTCTTCCACAAC
ACCATGGACAGGGAGGAGAGTGAAGGATGGCCGGCTATCGACGGCTCCTTCTTGGCTGCTGTTGGCAACCTCATCGTGGTCACTGCCAGC
TACCGAGTGGGTGTCTTCGGCTTCCTGAGTTCTGGGTCCGGAGAGGTGAGTGGCAACTGGGGGCTGCTGGACCAGGTGGCGGCTCTGACC
TGGGTGCAGACCCACATCCGAGGATTTGGCGGGGACCCTCGGCGCGTGTCCCTGGCAGCAGACCGTGGCGGGGCTGATGTGGCCAGCATC
CACCTTCTCACGGCCAGGGCCACCAACTCCCAACTTTTCCGGAGAGCTGTGCTGATGGGAGGCTCCGCACTCTCCCCGGCCGCCGTCATC
AGCCATGAGAGGGCTCAGCAGCAGGCAATTGCTTTGGCAAAGGAGGTCAGTTGCCCCATGTCATCCAGCCAAGAAGTGGTGTCCTGCCTC
CGCCAGAAGCCTGCCAATGTCCTCAATGATGCCCAGACCAAGCTCCTGGCCGTGAGTGGCCCTTTCCACTACTGGGGTCCTGTGATCGAT
GGCCACTTCCTCCGTGAGCCTCCAGCCAGAGCACTGAAGAGGTCTTTATGGGTAGAGGTCGATCTGCTCATTGGGAGTTCTCAGGACGAC
GGGCTCATCAACAGAGCAAAGGCTGTGAAGCAATTTGAGGAAAGTCGAGGCCGGACCAGTAGCAAAACAGCCTTTTACCAGGCACTGCAG
AATTCTCTGGGTGGCGAGGACTCAGATGCCCGCGTCGAGGCTGCTGCTACATGGTATTACTCTCTGGAGCACTCCACGGATGACTATGCC
TCCTTCTCCCGGGCTCTGGAGAATGCCACCCGGGACTACTTTATCATCTGCCCTATAATCGACATGGCCAGTGCCTGGGCAAAGAGGGCC
CGAGGAAACGTCTTCATGTACCATGCTCCTGAAAACTACGGCCATGGCAGCCTGGAGCTGCTGGCGGATGTTCAGTTTGCCTTGGGGCTT
CCCTTCTACCCAGCCTACGAGGGGCAGTTTTCTCTGGAGGAGAAGAGCCTGTCGCTGAAAATCATGCAGTACTTTTCCCACTTCATCAGA
TCAGGAAATCCCAACTACCCTTATGAGTTCTCACGGAAAGTACCCACATTTGCAACCCCCTGGCCTGACTTTGTACCCCGTGCTGGTGGA
GAGAACTACAAGGAGTTCAGTGAGCTGCTCCCCAATCGACAGGGCCTGAAGAAAGCCGACTGCTCCTTCTGGTCCAAGTACATCTCGTCT
CTGAAGACATCTGCAGATGGAGCCAAGGGCGGGCAGTCAGCAGAGAGTGAAGAGGAGGAGTTGACGGCTGGATCTGGGCTAAGAGAAGAT
CTCCTAAGCCTCCAGGAACCAGGCTCTAAGACCTACAGCAAGTGACCAGCCCTTGAGCTCCCCAAAAACCTCACCCGAGGCTGCCCACTA

>79063_79063_4_SAMD12-TG_SAMD12_chr8_119592954_ENST00000409003_TG_chr8_133923622_ENST00000377869_length(amino acids)=1441AA_BP=64
MAVEALHCGLNPRGIDHPAHAEGIKLQIEGEGVESQSIKNKNFQKVPDQKGTPKRLQAEAETAKVKTFGTLVSIPVCNNSSVQVGCLTRE
RLGVNVTWKSRLEDIPVASLPDLHDIERALVGKDLLGRFTDLIQSGSFQLHLDSKTFPAETIRFLQGDHFGTSPRTWFGCSEGFYQVLTS
EASQDGLGCVKCPEGSYSQDEECIPCPVGFYQEQAGSLACVPCPVGRTTISAGAFSQTHLMQKFEKVPESKVIFDANAPVAVRSKVPDSE
FPVMQCLTDCTEDEACSFFTVSTTEPEISCDFYAWTSDNVACMTSDQKRDALGNSKATSFGSLRCQVKVRSHGQDSPAVYLKKGQGSTTT
LQKRFEPTGFQNMLSGLYNPIVFSASGANLTDAHLFCLLACDRDLCCDGFVLTQVQGGAIICGLLSSPSVLLCNVKDWMDPSEAWANATC
PGVTYDQESHQVILRLGDQEFIKSLTPLEGTQDTFTNFQQVYLWKDSDMGSRPESMGCRKDTVPRPASPTEAGLTTELFSPVDLNQVIVN
GNQSLSSQKHWLFKHLFSAQQANLWCLSRCVQEHSFCQLAEITESASLYFTCTLYPEAQVCDDIMESNAQGCRLILPQMPKALFRKKVIL
EDKVKNFYTRLPFQKLMGISIRNKVPMSEKSISNGFFECERRCDADPCCTGFGFLNVSQLKGGEVTCLTLNSLGIQMCSEENGGAWRILD
CGSPDIEVHTYPFGWYQKPIAQNNAPSFCPLVVLPSLTEKVSLDSWQSLALSSVVVDPSIRHFDVAHVSTAATSNFSAVRDLCLSECSQH
EACLITTLQTQPGAVRCMFYADTQSCTHSLQGQNCRLLLREEATHIYRKPGISLLSYEASVPSVPISTHGRLLGRSQAIQVGTSWKQVDQ
FLGVPYAAPPLAERRFQAPEPLNWTGSWDASKPRASCWQPGTRTSTSPGVSEDCLYLNVFIPQNVAPNASVLVFFHNTMDREESEGWPAI
DGSFLAAVGNLIVVTASYRVGVFGFLSSGSGEVSGNWGLLDQVAALTWVQTHIRGFGGDPRRVSLAADRGGADVASIHLLTARATNSQLF
RRAVLMGGSALSPAAVISHERAQQQAIALAKEVSCPMSSSQEVVSCLRQKPANVLNDAQTKLLAVSGPFHYWGPVIDGHFLREPPARALK
RSLWVEVDLLIGSSQDDGLINRAKAVKQFEESRGRTSSKTAFYQALQNSLGGEDSDARVEAAATWYYSLEHSTDDYASFSRALENATRDY
FIICPIIDMASAWAKRARGNVFMYHAPENYGHGSLELLADVQFALGLPFYPAYEGQFSLEEKSLSLKIMQYFSHFIRSGNPNYPYEFSRK
VPTFATPWPDFVPRAGGENYKEFSELLPNRQGLKKADCSFWSKYISSLKTSADGAKGGQSAESEEEELTAGSGLREDLLSLQEPGSKTYS

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Fusion Gene PPI Analysis for SAMD12-TG


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for SAMD12-TG


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for SAMD12-TG


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource