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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:SAMM50-TXNRD2 (FusionGDB2 ID:79126)

Fusion Gene Summary for SAMM50-TXNRD2

check button Fusion gene summary
Fusion gene informationFusion gene name: SAMM50-TXNRD2
Fusion gene ID: 79126
HgeneTgene
Gene symbol

SAMM50

TXNRD2

Gene ID

25813

10587

Gene nameSAMM50 sorting and assembly machinery componentthioredoxin reductase 2
SynonymsCGI-51|OMP85|SAM50|TOB55|TRG-3|YNL026WGCCD5|SELZ|TR|TR-BETA|TR3|TRXR2
Cytomap

22q13.31

22q11.21

Type of geneprotein-codingprotein-coding
Descriptionsorting and assembly machinery component 50 homologsorting and assembly machinery 50kDatransformation-related gene 3 proteinthioredoxin reductase 2, mitochondrialselenoprotein Zthioredoxin reductase 3thioredoxin reductase TR3thioredoxin reductase beta
Modification date2020032720200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000493161, ENST00000350028, 
ENST00000396202, 		ENST00000334363, 
ENST00000400518, ENST00000400519, 
ENST00000400521, ENST00000535882, 
ENST00000542719, ENST00000491939, 
Fusion gene scores* DoF score8 X 8 X 4=2565 X 4 X 4=80
# samples 95
** MAII scorelog2(9/256*10)=-1.50814690367033
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(5/80*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SAMM50 [Title/Abstract] AND TXNRD2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointSAMM50(44351478)-TXNRD2(19918618), # samples:1
SAMM50(44351478)-TXNRD2(19918621), # samples:1
Anticipated loss of major functional domain due to fusion event.SAMM50-TXNRD2 seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
SAMM50-TXNRD2 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
SAMM50-TXNRD2 seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
SAMM50-TXNRD2 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneSAMM50

GO:0045040

protein import into mitochondrial outer membrane

15644312


check buttonFusion gene breakpoints across SAMM50 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across TXNRD2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4KIRPTCGA-BQ-7056-01ASAMM50chr22

44351478

-TXNRD2chr22

19918621

-
ChimerDB4KIRPTCGA-BQ-7056SAMM50chr22

44351478

+TXNRD2chr22

19918618

-


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Fusion Gene ORF analysis for SAMM50-TXNRD2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000493161ENST00000334363SAMM50chr22

44351478

-TXNRD2chr22

19918621

-
3UTR-3CDSENST00000493161ENST00000334363SAMM50chr22

44351478

+TXNRD2chr22

19918618

-
3UTR-3CDSENST00000493161ENST00000400518SAMM50chr22

44351478

-TXNRD2chr22

19918621

-
3UTR-3CDSENST00000493161ENST00000400518SAMM50chr22

44351478

+TXNRD2chr22

19918618

-
3UTR-3CDSENST00000493161ENST00000400519SAMM50chr22

44351478

-TXNRD2chr22

19918621

-
3UTR-3CDSENST00000493161ENST00000400519SAMM50chr22

44351478

+TXNRD2chr22

19918618

-
3UTR-3CDSENST00000493161ENST00000400521SAMM50chr22

44351478

-TXNRD2chr22

19918621

-
3UTR-3CDSENST00000493161ENST00000400521SAMM50chr22

44351478

+TXNRD2chr22

19918618

-
3UTR-3CDSENST00000493161ENST00000535882SAMM50chr22

44351478

-TXNRD2chr22

19918621

-
3UTR-3CDSENST00000493161ENST00000535882SAMM50chr22

44351478

+TXNRD2chr22

19918618

-
3UTR-3CDSENST00000493161ENST00000542719SAMM50chr22

44351478

-TXNRD2chr22

19918621

-
3UTR-3CDSENST00000493161ENST00000542719SAMM50chr22

44351478

+TXNRD2chr22

19918618

-
3UTR-5UTRENST00000493161ENST00000491939SAMM50chr22

44351478

-TXNRD2chr22

19918621

-
3UTR-5UTRENST00000493161ENST00000491939SAMM50chr22

44351478

+TXNRD2chr22

19918618

-
5CDS-5UTRENST00000350028ENST00000491939SAMM50chr22

44351478

-TXNRD2chr22

19918621

-
5CDS-5UTRENST00000350028ENST00000491939SAMM50chr22

44351478

+TXNRD2chr22

19918618

-
5UTR-3CDSENST00000396202ENST00000334363SAMM50chr22

44351478

-TXNRD2chr22

19918621

-
5UTR-3CDSENST00000396202ENST00000334363SAMM50chr22

44351478

+TXNRD2chr22

19918618

-
5UTR-3CDSENST00000396202ENST00000400518SAMM50chr22

44351478

-TXNRD2chr22

19918621

-
5UTR-3CDSENST00000396202ENST00000400518SAMM50chr22

44351478

+TXNRD2chr22

19918618

-
5UTR-3CDSENST00000396202ENST00000400519SAMM50chr22

44351478

-TXNRD2chr22

19918621

-
5UTR-3CDSENST00000396202ENST00000400519SAMM50chr22

44351478

+TXNRD2chr22

19918618

-
5UTR-3CDSENST00000396202ENST00000400521SAMM50chr22

44351478

-TXNRD2chr22

19918621

-
5UTR-3CDSENST00000396202ENST00000400521SAMM50chr22

44351478

+TXNRD2chr22

19918618

-
5UTR-3CDSENST00000396202ENST00000535882SAMM50chr22

44351478

-TXNRD2chr22

19918621

-
5UTR-3CDSENST00000396202ENST00000535882SAMM50chr22

44351478

+TXNRD2chr22

19918618

-
5UTR-3CDSENST00000396202ENST00000542719SAMM50chr22

44351478

-TXNRD2chr22

19918621

-
5UTR-3CDSENST00000396202ENST00000542719SAMM50chr22

44351478

+TXNRD2chr22

19918618

-
5UTR-5UTRENST00000396202ENST00000491939SAMM50chr22

44351478

-TXNRD2chr22

19918621

-
5UTR-5UTRENST00000396202ENST00000491939SAMM50chr22

44351478

+TXNRD2chr22

19918618

-
Frame-shiftENST00000350028ENST00000334363SAMM50chr22

44351478

-TXNRD2chr22

19918621

-
Frame-shiftENST00000350028ENST00000334363SAMM50chr22

44351478

+TXNRD2chr22

19918618

-
Frame-shiftENST00000350028ENST00000400519SAMM50chr22

44351478

-TXNRD2chr22

19918621

-
Frame-shiftENST00000350028ENST00000400519SAMM50chr22

44351478

+TXNRD2chr22

19918618

-
Frame-shiftENST00000350028ENST00000535882SAMM50chr22

44351478

-TXNRD2chr22

19918621

-
Frame-shiftENST00000350028ENST00000535882SAMM50chr22

44351478

+TXNRD2chr22

19918618

-
In-frameENST00000350028ENST00000400518SAMM50chr22

44351478

-TXNRD2chr22

19918621

-
In-frameENST00000350028ENST00000400518SAMM50chr22

44351478

+TXNRD2chr22

19918618

-
In-frameENST00000350028ENST00000400521SAMM50chr22

44351478

-TXNRD2chr22

19918621

-
In-frameENST00000350028ENST00000400521SAMM50chr22

44351478

+TXNRD2chr22

19918618

-
In-frameENST00000350028ENST00000542719SAMM50chr22

44351478

-TXNRD2chr22

19918621

-
In-frameENST00000350028ENST00000542719SAMM50chr22

44351478

+TXNRD2chr22

19918618

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000350028SAMM50chr2244351478+ENST00000400521TXNRD2chr2219918618-200117891643544
ENST00000350028SAMM50chr2244351478+ENST00000400518TXNRD2chr2219918618-200617891643544
ENST00000350028SAMM50chr2244351478+ENST00000542719TXNRD2chr2219918618-192017891643544
ENST00000350028SAMM50chr2244351478-ENST00000400521TXNRD2chr2219918621-200117891643544
ENST00000350028SAMM50chr2244351478-ENST00000400518TXNRD2chr2219918621-200617891643544
ENST00000350028SAMM50chr2244351478-ENST00000542719TXNRD2chr2219918621-192017891643544

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000350028ENST00000400521SAMM50chr2244351478+TXNRD2chr2219918618-0.015236490.98476356
ENST00000350028ENST00000400518SAMM50chr2244351478+TXNRD2chr2219918618-0.0145755230.98542446
ENST00000350028ENST00000542719SAMM50chr2244351478+TXNRD2chr2219918618-0.0168521740.98314786
ENST00000350028ENST00000400521SAMM50chr2244351478-TXNRD2chr2219918621-0.015236490.98476356
ENST00000350028ENST00000400518SAMM50chr2244351478-TXNRD2chr2219918621-0.0145755230.98542446
ENST00000350028ENST00000542719SAMM50chr2244351478-TXNRD2chr2219918621-0.0168521740.98314786

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Fusion Genomic Features for SAMM50-TXNRD2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for SAMM50-TXNRD2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr22:44351478/chr22:19918618)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneTXNRD2chr22:44351478chr22:19918618ENST0000040052101841_7034625.6666666666666Nucleotide bindingFAD
TgeneTXNRD2chr22:44351478chr22:19918621ENST0000040052101841_7034625.6666666666666Nucleotide bindingFAD

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSAMM50chr22:44351478chr22:19918618ENST00000350028+11545_1257470.0DomainPOTRA
HgeneSAMM50chr22:44351478chr22:19918621ENST00000350028-11545_1257470.0DomainPOTRA


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Fusion Gene Sequence for SAMM50-TXNRD2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>79126_79126_1_SAMM50-TXNRD2_SAMM50_chr22_44351478_ENST00000350028_TXNRD2_chr22_19918618_ENST00000400518_length(transcript)=2006nt_BP=178nt
CGGGGAATCATGGCCGCCCCCAGTGTTCCGCGTCCGGGGGTTTGTGGGAGTTGCCTTGACCTGCAGCTCCGCCACCGCGGACCCGCCTTC
TGCCCTCAGCAGCAGACGCTCTGTCCCGCCCGGGCAGCTCTGCGAGGCAGCGGCTGGAGAGGGAACCATGGGGACTGTGCACGCCCGGCA
GGTCAGCGGGACTATGATCTCCTGGTGGTCGGCGGGGGATCTGGTGGCCTGGCTTGTGCCAAGGAGGCCGCCCAGCTGGGAAGGAAGGTG
GCCGTGGTGGACTACGTGGAACCTTCTCCCCAAGGCACCCGGTGGGGCCTCGGCGGCACCTGCGTCAACGTGGGCTGCATCCCCAAGAAG
CTGATGCACCAGGCGGCACTGCTGGGAGGCCTGATCCAAGATGCCCCCAACTATGGCTGGGAGGTGGCCCAGCCCGTGCCGCATGACTGG
AGGAAGATGGCAGAAGCTGTTCAAAATCACGTGAAATCCTTGAACTGGGGCCACCGTGTCCAGCTTCAGGACAGAAAAGTCAAGTACTTT
AACATCAAAGCCAGCTTTGTTGACGAGCACACGGTTTGCGGCGTTGCCAAAGGTGGGAAAGAGATTCTGCTGTCAGCCGATCACATCATC
ATTGCTACTGGAGGGCGGCCGAGATACCCCACGCACATCGAAGGTGCCTTGGAATATGGAATCACAAGTGATGACATCTTCTGGCTGAAG
GAATCCCCTGGAAAAACGTTGGTGGTCGGGGCCAGCTATGTGGCCCTGGAGTGTGCTGGCTTCCTCACCGGGATTGGGCTGGACACCACC
ATCATGATGCGCAGCATCCCCCTCCGCGGCTTCGACCAGCAAATGTCCTCCATGGTCATAGAGCACATGGCATCTCATGGCACCCGGTTC
CTGAGGGGCTGTGCCCCCTCGCGGGTCAGGAGGCTCCCTGATGGCCAGCTGCAGGTCACCTGGGAGGACAGCACCACCGGCAAGGAGGAC
ACGGGCACCTTTGACACCGTCCTGTGGGCCATAGGTCGAGTCCCAGACACCAGAAGTCTGAATTTGGAGAAGGCTGGGGTAGATACTAGC
CCCGACACTCAGAAGATCCTGGTGGACTCCCGGGAAGCCACCTCTGTGCCCCACATCTACGCCATTGGTGACGTGGTGGAGGGGCGGCCT
GAGCTGACACCCATAGCGATCATGGCCGGGAGGCTCCTGGTGCAGCGGCTCTTCGGCGGGTCCTCAGATCTGATGGACTACGACAATGTT
CCCACGACCGTCTTCACCCCGCTGGAGTATGGCTGTGTGGGGCTGTCCGAGGAGGAGGCAGTGGCTCGCCACGGGCAGGAGCATGTTGAG
GTCTATCACGCCCATTATAAACCACTGGAGTTCACGGTGGCTGGACGAGATGCATCCCAGTGTTATGTAAAGATGGTGTGCCTGAGGGAG
CCCCCACAGCTGGTGCTGGGCCTGCATTTCCTTGGCCCCAACGCAGGCGAAGTTACTCAAGGATTTGCTCTGGGGATCAAGTGTGGGGCT
TCCTATGCGCAGGTGATGCGGACCGTGGGTATCCATCCCACATGCTCTGAGGAGGTAGTCAAGCTGCGCATCTCCAAGCGCTCAGGCCTG
GACCCCACGGTGACAGGCTGCTGAGGGTAAGCGCCATCCCTGCAGGCCAGGGCACACGGTGCGCCCGCCGCCAGCTCCTCGGAGGCCAGA
CCCAGGATGGCTGCAGGCCAGGTTTGGGGGGCCTCAACCCTCTCCTGGAGCGCCTGTGAGATGGTCAGCGTGGAGCGCAAGTGCTGGACA
GGTGGCCCGTGTGCCCCACAGGGATGGCTCAGGGGACTGTCCACCTCACCCCTGCACCTCTCAGCCTCTGCCGCCGGGCACCCCCCCCCA
GGCTCCTGGTGCCAGATGATGACGACCTGGGTGGAAACCTACCCTGTGGGCACCCATGTCCGAGCCCCCTGGCATTTCTGCAATGCAAAT

>79126_79126_1_SAMM50-TXNRD2_SAMM50_chr22_44351478_ENST00000350028_TXNRD2_chr22_19918618_ENST00000400518_length(amino acids)=544AA_BP=56
MAAPSVPRPGVCGSCLDLQLRHRGPAFCPQQQTLCPARAALRGSGWRGNHGDCARPAGQRDYDLLVVGGGSGGLACAKEAAQLGRKVAVV
DYVEPSPQGTRWGLGGTCVNVGCIPKKLMHQAALLGGLIQDAPNYGWEVAQPVPHDWRKMAEAVQNHVKSLNWGHRVQLQDRKVKYFNIK
ASFVDEHTVCGVAKGGKEILLSADHIIIATGGRPRYPTHIEGALEYGITSDDIFWLKESPGKTLVVGASYVALECAGFLTGIGLDTTIMM
RSIPLRGFDQQMSSMVIEHMASHGTRFLRGCAPSRVRRLPDGQLQVTWEDSTTGKEDTGTFDTVLWAIGRVPDTRSLNLEKAGVDTSPDT
QKILVDSREATSVPHIYAIGDVVEGRPELTPIAIMAGRLLVQRLFGGSSDLMDYDNVPTTVFTPLEYGCVGLSEEEAVARHGQEHVEVYH
AHYKPLEFTVAGRDASQCYVKMVCLREPPQLVLGLHFLGPNAGEVTQGFALGIKCGASYAQVMRTVGIHPTCSEEVVKLRISKRSGLDPT

--------------------------------------------------------------
>79126_79126_2_SAMM50-TXNRD2_SAMM50_chr22_44351478_ENST00000350028_TXNRD2_chr22_19918618_ENST00000400521_length(transcript)=2001nt_BP=178nt
CGGGGAATCATGGCCGCCCCCAGTGTTCCGCGTCCGGGGGTTTGTGGGAGTTGCCTTGACCTGCAGCTCCGCCACCGCGGACCCGCCTTC
TGCCCTCAGCAGCAGACGCTCTGTCCCGCCCGGGCAGCTCTGCGAGGCAGCGGCTGGAGAGGGAACCATGGGGACTGTGCACGCCCGGCA
GGTCAGCGGGACTATGATCTCCTGGTGGTCGGCGGGGGATCTGGTGGCCTGGCTTGTGCCAAGGAGGCCGCCCAGCTGGGAAGGAAGGTG
GCCGTGGTGGACTACGTGGAACCTTCTCCCCAAGGCACCCGGTGGGGCCTCGGCGGCACCTGCGTCAACGTGGGCTGCATCCCCAAGAAG
CTGATGCACCAGGCGGCACTGCTGGGAGGCCTGATCCAAGATGCCCCCAACTATGGCTGGGAGGTGGCCCAGCCCGTGCCGCATGACTGG
AGGAAGATGGCAGAAGCTGTTCAAAATCACGTGAAATCCTTGAACTGGGGCCACCGTGTCCAGCTTCAGGACAGAAAAGTCAAGTACTTT
AACATCAAAGCCAGCTTTGTTGACGAGCACACGGTTTGCGGCGTTGCCAAAGGTGGGAAAGAGATTCTGCTGTCAGCCGATCACATCATC
ATTGCTACTGGAGGGCGGCCGAGATACCCCACGCACATCGAAGGTGCCTTGGAATATGGAATCACAAGTGATGACATCTTCTGGCTGAAG
GAATCCCCTGGAAAAACGTTGGTGGTCGGGGCCAGCTATGTGGCCCTGGAGTGTGCTGGCTTCCTCACCGGGATTGGGCTGGACACCACC
ATCATGATGCGCAGCATCCCCCTCCGCGGCTTCGACCAGCAAATGTCCTCCATGGTCATAGAGCACATGGCATCTCATGGCACCCGGTTC
CTGAGGGGCTGTGCCCCCTCGCGGGTCAGGAGGCTCCCTGATGGCCAGCTGCAGGTCACCTGGGAGGACAGCACCACCGGCAAGGAGGAC
ACGGGCACCTTTGACACCGTCCTGTGGGCCATAGGTCGAGTCCCAGACACCAGAAGTCTGAATTTGGAGAAGGCTGGGGTAGATACTAGC
CCCGACACTCAGAAGATCCTGGTGGACTCCCGGGAAGCCACCTCTGTGCCCCACATCTACGCCATTGGTGACGTGGTGGAGGGGCGGCCT
GAGCTGACACCCATAGCGATCATGGCCGGGAGGCTCCTGGTGCAGCGGCTCTTCGGCGGGTCCTCAGATCTGATGGACTACGACAATGTT
CCCACGACCGTCTTCACCCCGCTGGAGTATGGCTGTGTGGGGCTGTCCGAGGAGGAGGCAGTGGCTCGCCACGGGCAGGAGCATGTTGAG
GTCTATCACGCCCATTATAAACCACTGGAGTTCACGGTGGCTGGACGAGATGCATCCCAGTGTTATGTAAAGATGGTGTGCCTGAGGGAG
CCCCCACAGCTGGTGCTGGGCCTGCATTTCCTTGGCCCCAACGCAGGCGAAGTTACTCAAGGATTTGCTCTGGGGATCAAGTGTGGGGCT
TCCTATGCGCAGGTGATGCGGACCGTGGGTATCCATCCCACATGCTCTGAGGAGGTAGTCAAGCTGCGCATCTCCAAGCGCTCAGGCCTG
GACCCCACGGTGACAGGCTGCTGAGGGTAAGCGCCATCCCTGCAGGCCAGGGCACACGGTGCGCCCGCCGCCAGCTCCTCGGAGGCCAGA
CCCAGGATGGCTGCAGGCCAGGTTTGGGGGGCCTCAACCCTCTCCTGGAGCGCCTGTGAGATGGTCAGCGTGGAGCGCAAGTGCTGGACA
GGTGGCCCGTGTGCCCCACAGGGATGGCTCAGGGGACTGTCCACCTCACCCCTGCACCTCTCAGCCTCTGCCGCCGGGCACCCCCCCCCA
GGCTCCTGGTGCCAGATGATGACGACCTGGGTGGAAACCTACCCTGTGGGCACCCATGTCCGAGCCCCCTGGCATTTCTGCAATGCAAAT

>79126_79126_2_SAMM50-TXNRD2_SAMM50_chr22_44351478_ENST00000350028_TXNRD2_chr22_19918618_ENST00000400521_length(amino acids)=544AA_BP=56
MAAPSVPRPGVCGSCLDLQLRHRGPAFCPQQQTLCPARAALRGSGWRGNHGDCARPAGQRDYDLLVVGGGSGGLACAKEAAQLGRKVAVV
DYVEPSPQGTRWGLGGTCVNVGCIPKKLMHQAALLGGLIQDAPNYGWEVAQPVPHDWRKMAEAVQNHVKSLNWGHRVQLQDRKVKYFNIK
ASFVDEHTVCGVAKGGKEILLSADHIIIATGGRPRYPTHIEGALEYGITSDDIFWLKESPGKTLVVGASYVALECAGFLTGIGLDTTIMM
RSIPLRGFDQQMSSMVIEHMASHGTRFLRGCAPSRVRRLPDGQLQVTWEDSTTGKEDTGTFDTVLWAIGRVPDTRSLNLEKAGVDTSPDT
QKILVDSREATSVPHIYAIGDVVEGRPELTPIAIMAGRLLVQRLFGGSSDLMDYDNVPTTVFTPLEYGCVGLSEEEAVARHGQEHVEVYH
AHYKPLEFTVAGRDASQCYVKMVCLREPPQLVLGLHFLGPNAGEVTQGFALGIKCGASYAQVMRTVGIHPTCSEEVVKLRISKRSGLDPT

--------------------------------------------------------------
>79126_79126_3_SAMM50-TXNRD2_SAMM50_chr22_44351478_ENST00000350028_TXNRD2_chr22_19918618_ENST00000542719_length(transcript)=1920nt_BP=178nt
CGGGGAATCATGGCCGCCCCCAGTGTTCCGCGTCCGGGGGTTTGTGGGAGTTGCCTTGACCTGCAGCTCCGCCACCGCGGACCCGCCTTC
TGCCCTCAGCAGCAGACGCTCTGTCCCGCCCGGGCAGCTCTGCGAGGCAGCGGCTGGAGAGGGAACCATGGGGACTGTGCACGCCCGGCA
GGTCAGCGGGACTATGATCTCCTGGTGGTCGGCGGGGGATCTGGTGGCCTGGCTTGTGCCAAGGAGGCCGCCCAGCTGGGAAGGAAGGTG
GCCGTGGTGGACTACGTGGAACCTTCTCCCCAAGGCACCCGGTGGGGCCTCGGCGGCACCTGCGTCAACGTGGGCTGCATCCCCAAGAAG
CTGATGCACCAGGCGGCACTGCTGGGAGGCCTGATCCAAGATGCCCCCAACTATGGCTGGGAGGTGGCCCAGCCCGTGCCGCATGACTGG
AGGAAGATGGCAGAAGCTGTTCAAAATCACGTGAAATCCTTGAACTGGGGCCACCGTGTCCAGCTTCAGGACAGAAAAGTCAAGTACTTT
AACATCAAAGCCAGCTTTGTTGACGAGCACACGGTTTGCGGCGTTGCCAAAGGTGGGAAAGAGATTCTGCTGTCAGCCGATCACATCATC
ATTGCTACTGGAGGGCGGCCGAGATACCCCACGCACATCGAAGGTGCCTTGGAATATGGAATCACAAGTGATGACATCTTCTGGCTGAAG
GAATCCCCTGGAAAAACGTTGGTGGTCGGGGCCAGCTATGTGGCCCTGGAGTGTGCTGGCTTCCTCACCGGGATTGGGCTGGACACCACC
ATCATGATGCGCAGCATCCCCCTCCGCGGCTTCGACCAGCAAATGTCCTCCATGGTCATAGAGCACATGGCATCTCATGGCACCCGGTTC
CTGAGGGGCTGTGCCCCCTCGCGGGTCAGGAGGCTCCCTGATGGCCAGCTGCAGGTCACCTGGGAGGACAGCACCACCGGCAAGGAGGAC
ACGGGCACCTTTGACACCGTCCTGTGGGCCATAGGTCGAGTCCCAGACACCAGAAGTCTGAATTTGGAGAAGGCTGGGGTAGATACTAGC
CCCGACACTCAGAAGATCCTGGTGGACTCCCGGGAAGCCACCTCTGTGCCCCACATCTACGCCATTGGTGACGTGGTGGAGGGGCGGCCT
GAGCTGACACCCATAGCGATCATGGCCGGGAGGCTCCTGGTGCAGCGGCTCTTCGGCGGGTCCTCAGATCTGATGGACTACGACAATGTT
CCCACGACCGTCTTCACCCCGCTGGAGTATGGCTGTGTGGGGCTGTCCGAGGAGGAGGCAGTGGCTCGCCACGGGCAGGAGCATGTTGAG
GTCTATCACGCCCATTATAAACCACTGGAGTTCACGGTGGCTGGACGAGATGCATCCCAGTGTTATGTAAAGATGGTGTGCCTGAGGGAG
CCCCCACAGCTGGTGCTGGGCCTGCATTTCCTTGGCCCCAACGCAGGCGAAGTTACTCAAGGATTTGCTCTGGGGATCAAGTGTGGGGCT
TCCTATGCGCAGGTGATGCGGACCGTGGGTATCCATCCCACATGCTCTGAGGAGGTAGTCAAGCTGCGCATCTCCAAGCGCTCAGGCCTG
GACCCCACGGTGACAGGCTGCTGAGGGTAAGCGCCATCCCTGCAGGCCAGGGCACACGGTGCGCCCGCCGCCAGCTCCTCGGAGGCCAGA
CCCAGGATGGCTGCAGGCCAGGTTTGGGGGGCCTCAACCCTCTCCTGGAGCGCCTGTGAGATGGTCAGCGTGGAGCGCAAGTGCTGGACA
GGTGGCCCGTGTGCCCCACAGGGATGGCTCAGGGGACTGTCCACCTCACCCCTGCACCTCTCAGCCTCTGCCGCCGGGCACCCCCCCCCA

>79126_79126_3_SAMM50-TXNRD2_SAMM50_chr22_44351478_ENST00000350028_TXNRD2_chr22_19918618_ENST00000542719_length(amino acids)=544AA_BP=56
MAAPSVPRPGVCGSCLDLQLRHRGPAFCPQQQTLCPARAALRGSGWRGNHGDCARPAGQRDYDLLVVGGGSGGLACAKEAAQLGRKVAVV
DYVEPSPQGTRWGLGGTCVNVGCIPKKLMHQAALLGGLIQDAPNYGWEVAQPVPHDWRKMAEAVQNHVKSLNWGHRVQLQDRKVKYFNIK
ASFVDEHTVCGVAKGGKEILLSADHIIIATGGRPRYPTHIEGALEYGITSDDIFWLKESPGKTLVVGASYVALECAGFLTGIGLDTTIMM
RSIPLRGFDQQMSSMVIEHMASHGTRFLRGCAPSRVRRLPDGQLQVTWEDSTTGKEDTGTFDTVLWAIGRVPDTRSLNLEKAGVDTSPDT
QKILVDSREATSVPHIYAIGDVVEGRPELTPIAIMAGRLLVQRLFGGSSDLMDYDNVPTTVFTPLEYGCVGLSEEEAVARHGQEHVEVYH
AHYKPLEFTVAGRDASQCYVKMVCLREPPQLVLGLHFLGPNAGEVTQGFALGIKCGASYAQVMRTVGIHPTCSEEVVKLRISKRSGLDPT

--------------------------------------------------------------
>79126_79126_4_SAMM50-TXNRD2_SAMM50_chr22_44351478_ENST00000350028_TXNRD2_chr22_19918621_ENST00000400518_length(transcript)=2006nt_BP=178nt
CGGGGAATCATGGCCGCCCCCAGTGTTCCGCGTCCGGGGGTTTGTGGGAGTTGCCTTGACCTGCAGCTCCGCCACCGCGGACCCGCCTTC
TGCCCTCAGCAGCAGACGCTCTGTCCCGCCCGGGCAGCTCTGCGAGGCAGCGGCTGGAGAGGGAACCATGGGGACTGTGCACGCCCGGCA
GGTCAGCGGGACTATGATCTCCTGGTGGTCGGCGGGGGATCTGGTGGCCTGGCTTGTGCCAAGGAGGCCGCCCAGCTGGGAAGGAAGGTG
GCCGTGGTGGACTACGTGGAACCTTCTCCCCAAGGCACCCGGTGGGGCCTCGGCGGCACCTGCGTCAACGTGGGCTGCATCCCCAAGAAG
CTGATGCACCAGGCGGCACTGCTGGGAGGCCTGATCCAAGATGCCCCCAACTATGGCTGGGAGGTGGCCCAGCCCGTGCCGCATGACTGG
AGGAAGATGGCAGAAGCTGTTCAAAATCACGTGAAATCCTTGAACTGGGGCCACCGTGTCCAGCTTCAGGACAGAAAAGTCAAGTACTTT
AACATCAAAGCCAGCTTTGTTGACGAGCACACGGTTTGCGGCGTTGCCAAAGGTGGGAAAGAGATTCTGCTGTCAGCCGATCACATCATC
ATTGCTACTGGAGGGCGGCCGAGATACCCCACGCACATCGAAGGTGCCTTGGAATATGGAATCACAAGTGATGACATCTTCTGGCTGAAG
GAATCCCCTGGAAAAACGTTGGTGGTCGGGGCCAGCTATGTGGCCCTGGAGTGTGCTGGCTTCCTCACCGGGATTGGGCTGGACACCACC
ATCATGATGCGCAGCATCCCCCTCCGCGGCTTCGACCAGCAAATGTCCTCCATGGTCATAGAGCACATGGCATCTCATGGCACCCGGTTC
CTGAGGGGCTGTGCCCCCTCGCGGGTCAGGAGGCTCCCTGATGGCCAGCTGCAGGTCACCTGGGAGGACAGCACCACCGGCAAGGAGGAC
ACGGGCACCTTTGACACCGTCCTGTGGGCCATAGGTCGAGTCCCAGACACCAGAAGTCTGAATTTGGAGAAGGCTGGGGTAGATACTAGC
CCCGACACTCAGAAGATCCTGGTGGACTCCCGGGAAGCCACCTCTGTGCCCCACATCTACGCCATTGGTGACGTGGTGGAGGGGCGGCCT
GAGCTGACACCCATAGCGATCATGGCCGGGAGGCTCCTGGTGCAGCGGCTCTTCGGCGGGTCCTCAGATCTGATGGACTACGACAATGTT
CCCACGACCGTCTTCACCCCGCTGGAGTATGGCTGTGTGGGGCTGTCCGAGGAGGAGGCAGTGGCTCGCCACGGGCAGGAGCATGTTGAG
GTCTATCACGCCCATTATAAACCACTGGAGTTCACGGTGGCTGGACGAGATGCATCCCAGTGTTATGTAAAGATGGTGTGCCTGAGGGAG
CCCCCACAGCTGGTGCTGGGCCTGCATTTCCTTGGCCCCAACGCAGGCGAAGTTACTCAAGGATTTGCTCTGGGGATCAAGTGTGGGGCT
TCCTATGCGCAGGTGATGCGGACCGTGGGTATCCATCCCACATGCTCTGAGGAGGTAGTCAAGCTGCGCATCTCCAAGCGCTCAGGCCTG
GACCCCACGGTGACAGGCTGCTGAGGGTAAGCGCCATCCCTGCAGGCCAGGGCACACGGTGCGCCCGCCGCCAGCTCCTCGGAGGCCAGA
CCCAGGATGGCTGCAGGCCAGGTTTGGGGGGCCTCAACCCTCTCCTGGAGCGCCTGTGAGATGGTCAGCGTGGAGCGCAAGTGCTGGACA
GGTGGCCCGTGTGCCCCACAGGGATGGCTCAGGGGACTGTCCACCTCACCCCTGCACCTCTCAGCCTCTGCCGCCGGGCACCCCCCCCCA
GGCTCCTGGTGCCAGATGATGACGACCTGGGTGGAAACCTACCCTGTGGGCACCCATGTCCGAGCCCCCTGGCATTTCTGCAATGCAAAT

>79126_79126_4_SAMM50-TXNRD2_SAMM50_chr22_44351478_ENST00000350028_TXNRD2_chr22_19918621_ENST00000400518_length(amino acids)=544AA_BP=56
MAAPSVPRPGVCGSCLDLQLRHRGPAFCPQQQTLCPARAALRGSGWRGNHGDCARPAGQRDYDLLVVGGGSGGLACAKEAAQLGRKVAVV
DYVEPSPQGTRWGLGGTCVNVGCIPKKLMHQAALLGGLIQDAPNYGWEVAQPVPHDWRKMAEAVQNHVKSLNWGHRVQLQDRKVKYFNIK
ASFVDEHTVCGVAKGGKEILLSADHIIIATGGRPRYPTHIEGALEYGITSDDIFWLKESPGKTLVVGASYVALECAGFLTGIGLDTTIMM
RSIPLRGFDQQMSSMVIEHMASHGTRFLRGCAPSRVRRLPDGQLQVTWEDSTTGKEDTGTFDTVLWAIGRVPDTRSLNLEKAGVDTSPDT
QKILVDSREATSVPHIYAIGDVVEGRPELTPIAIMAGRLLVQRLFGGSSDLMDYDNVPTTVFTPLEYGCVGLSEEEAVARHGQEHVEVYH
AHYKPLEFTVAGRDASQCYVKMVCLREPPQLVLGLHFLGPNAGEVTQGFALGIKCGASYAQVMRTVGIHPTCSEEVVKLRISKRSGLDPT

--------------------------------------------------------------
>79126_79126_5_SAMM50-TXNRD2_SAMM50_chr22_44351478_ENST00000350028_TXNRD2_chr22_19918621_ENST00000400521_length(transcript)=2001nt_BP=178nt
CGGGGAATCATGGCCGCCCCCAGTGTTCCGCGTCCGGGGGTTTGTGGGAGTTGCCTTGACCTGCAGCTCCGCCACCGCGGACCCGCCTTC
TGCCCTCAGCAGCAGACGCTCTGTCCCGCCCGGGCAGCTCTGCGAGGCAGCGGCTGGAGAGGGAACCATGGGGACTGTGCACGCCCGGCA
GGTCAGCGGGACTATGATCTCCTGGTGGTCGGCGGGGGATCTGGTGGCCTGGCTTGTGCCAAGGAGGCCGCCCAGCTGGGAAGGAAGGTG
GCCGTGGTGGACTACGTGGAACCTTCTCCCCAAGGCACCCGGTGGGGCCTCGGCGGCACCTGCGTCAACGTGGGCTGCATCCCCAAGAAG
CTGATGCACCAGGCGGCACTGCTGGGAGGCCTGATCCAAGATGCCCCCAACTATGGCTGGGAGGTGGCCCAGCCCGTGCCGCATGACTGG
AGGAAGATGGCAGAAGCTGTTCAAAATCACGTGAAATCCTTGAACTGGGGCCACCGTGTCCAGCTTCAGGACAGAAAAGTCAAGTACTTT
AACATCAAAGCCAGCTTTGTTGACGAGCACACGGTTTGCGGCGTTGCCAAAGGTGGGAAAGAGATTCTGCTGTCAGCCGATCACATCATC
ATTGCTACTGGAGGGCGGCCGAGATACCCCACGCACATCGAAGGTGCCTTGGAATATGGAATCACAAGTGATGACATCTTCTGGCTGAAG
GAATCCCCTGGAAAAACGTTGGTGGTCGGGGCCAGCTATGTGGCCCTGGAGTGTGCTGGCTTCCTCACCGGGATTGGGCTGGACACCACC
ATCATGATGCGCAGCATCCCCCTCCGCGGCTTCGACCAGCAAATGTCCTCCATGGTCATAGAGCACATGGCATCTCATGGCACCCGGTTC
CTGAGGGGCTGTGCCCCCTCGCGGGTCAGGAGGCTCCCTGATGGCCAGCTGCAGGTCACCTGGGAGGACAGCACCACCGGCAAGGAGGAC
ACGGGCACCTTTGACACCGTCCTGTGGGCCATAGGTCGAGTCCCAGACACCAGAAGTCTGAATTTGGAGAAGGCTGGGGTAGATACTAGC
CCCGACACTCAGAAGATCCTGGTGGACTCCCGGGAAGCCACCTCTGTGCCCCACATCTACGCCATTGGTGACGTGGTGGAGGGGCGGCCT
GAGCTGACACCCATAGCGATCATGGCCGGGAGGCTCCTGGTGCAGCGGCTCTTCGGCGGGTCCTCAGATCTGATGGACTACGACAATGTT
CCCACGACCGTCTTCACCCCGCTGGAGTATGGCTGTGTGGGGCTGTCCGAGGAGGAGGCAGTGGCTCGCCACGGGCAGGAGCATGTTGAG
GTCTATCACGCCCATTATAAACCACTGGAGTTCACGGTGGCTGGACGAGATGCATCCCAGTGTTATGTAAAGATGGTGTGCCTGAGGGAG
CCCCCACAGCTGGTGCTGGGCCTGCATTTCCTTGGCCCCAACGCAGGCGAAGTTACTCAAGGATTTGCTCTGGGGATCAAGTGTGGGGCT
TCCTATGCGCAGGTGATGCGGACCGTGGGTATCCATCCCACATGCTCTGAGGAGGTAGTCAAGCTGCGCATCTCCAAGCGCTCAGGCCTG
GACCCCACGGTGACAGGCTGCTGAGGGTAAGCGCCATCCCTGCAGGCCAGGGCACACGGTGCGCCCGCCGCCAGCTCCTCGGAGGCCAGA
CCCAGGATGGCTGCAGGCCAGGTTTGGGGGGCCTCAACCCTCTCCTGGAGCGCCTGTGAGATGGTCAGCGTGGAGCGCAAGTGCTGGACA
GGTGGCCCGTGTGCCCCACAGGGATGGCTCAGGGGACTGTCCACCTCACCCCTGCACCTCTCAGCCTCTGCCGCCGGGCACCCCCCCCCA
GGCTCCTGGTGCCAGATGATGACGACCTGGGTGGAAACCTACCCTGTGGGCACCCATGTCCGAGCCCCCTGGCATTTCTGCAATGCAAAT

>79126_79126_5_SAMM50-TXNRD2_SAMM50_chr22_44351478_ENST00000350028_TXNRD2_chr22_19918621_ENST00000400521_length(amino acids)=544AA_BP=56
MAAPSVPRPGVCGSCLDLQLRHRGPAFCPQQQTLCPARAALRGSGWRGNHGDCARPAGQRDYDLLVVGGGSGGLACAKEAAQLGRKVAVV
DYVEPSPQGTRWGLGGTCVNVGCIPKKLMHQAALLGGLIQDAPNYGWEVAQPVPHDWRKMAEAVQNHVKSLNWGHRVQLQDRKVKYFNIK
ASFVDEHTVCGVAKGGKEILLSADHIIIATGGRPRYPTHIEGALEYGITSDDIFWLKESPGKTLVVGASYVALECAGFLTGIGLDTTIMM
RSIPLRGFDQQMSSMVIEHMASHGTRFLRGCAPSRVRRLPDGQLQVTWEDSTTGKEDTGTFDTVLWAIGRVPDTRSLNLEKAGVDTSPDT
QKILVDSREATSVPHIYAIGDVVEGRPELTPIAIMAGRLLVQRLFGGSSDLMDYDNVPTTVFTPLEYGCVGLSEEEAVARHGQEHVEVYH
AHYKPLEFTVAGRDASQCYVKMVCLREPPQLVLGLHFLGPNAGEVTQGFALGIKCGASYAQVMRTVGIHPTCSEEVVKLRISKRSGLDPT

--------------------------------------------------------------
>79126_79126_6_SAMM50-TXNRD2_SAMM50_chr22_44351478_ENST00000350028_TXNRD2_chr22_19918621_ENST00000542719_length(transcript)=1920nt_BP=178nt
CGGGGAATCATGGCCGCCCCCAGTGTTCCGCGTCCGGGGGTTTGTGGGAGTTGCCTTGACCTGCAGCTCCGCCACCGCGGACCCGCCTTC
TGCCCTCAGCAGCAGACGCTCTGTCCCGCCCGGGCAGCTCTGCGAGGCAGCGGCTGGAGAGGGAACCATGGGGACTGTGCACGCCCGGCA
GGTCAGCGGGACTATGATCTCCTGGTGGTCGGCGGGGGATCTGGTGGCCTGGCTTGTGCCAAGGAGGCCGCCCAGCTGGGAAGGAAGGTG
GCCGTGGTGGACTACGTGGAACCTTCTCCCCAAGGCACCCGGTGGGGCCTCGGCGGCACCTGCGTCAACGTGGGCTGCATCCCCAAGAAG
CTGATGCACCAGGCGGCACTGCTGGGAGGCCTGATCCAAGATGCCCCCAACTATGGCTGGGAGGTGGCCCAGCCCGTGCCGCATGACTGG
AGGAAGATGGCAGAAGCTGTTCAAAATCACGTGAAATCCTTGAACTGGGGCCACCGTGTCCAGCTTCAGGACAGAAAAGTCAAGTACTTT
AACATCAAAGCCAGCTTTGTTGACGAGCACACGGTTTGCGGCGTTGCCAAAGGTGGGAAAGAGATTCTGCTGTCAGCCGATCACATCATC
ATTGCTACTGGAGGGCGGCCGAGATACCCCACGCACATCGAAGGTGCCTTGGAATATGGAATCACAAGTGATGACATCTTCTGGCTGAAG
GAATCCCCTGGAAAAACGTTGGTGGTCGGGGCCAGCTATGTGGCCCTGGAGTGTGCTGGCTTCCTCACCGGGATTGGGCTGGACACCACC
ATCATGATGCGCAGCATCCCCCTCCGCGGCTTCGACCAGCAAATGTCCTCCATGGTCATAGAGCACATGGCATCTCATGGCACCCGGTTC
CTGAGGGGCTGTGCCCCCTCGCGGGTCAGGAGGCTCCCTGATGGCCAGCTGCAGGTCACCTGGGAGGACAGCACCACCGGCAAGGAGGAC
ACGGGCACCTTTGACACCGTCCTGTGGGCCATAGGTCGAGTCCCAGACACCAGAAGTCTGAATTTGGAGAAGGCTGGGGTAGATACTAGC
CCCGACACTCAGAAGATCCTGGTGGACTCCCGGGAAGCCACCTCTGTGCCCCACATCTACGCCATTGGTGACGTGGTGGAGGGGCGGCCT
GAGCTGACACCCATAGCGATCATGGCCGGGAGGCTCCTGGTGCAGCGGCTCTTCGGCGGGTCCTCAGATCTGATGGACTACGACAATGTT
CCCACGACCGTCTTCACCCCGCTGGAGTATGGCTGTGTGGGGCTGTCCGAGGAGGAGGCAGTGGCTCGCCACGGGCAGGAGCATGTTGAG
GTCTATCACGCCCATTATAAACCACTGGAGTTCACGGTGGCTGGACGAGATGCATCCCAGTGTTATGTAAAGATGGTGTGCCTGAGGGAG
CCCCCACAGCTGGTGCTGGGCCTGCATTTCCTTGGCCCCAACGCAGGCGAAGTTACTCAAGGATTTGCTCTGGGGATCAAGTGTGGGGCT
TCCTATGCGCAGGTGATGCGGACCGTGGGTATCCATCCCACATGCTCTGAGGAGGTAGTCAAGCTGCGCATCTCCAAGCGCTCAGGCCTG
GACCCCACGGTGACAGGCTGCTGAGGGTAAGCGCCATCCCTGCAGGCCAGGGCACACGGTGCGCCCGCCGCCAGCTCCTCGGAGGCCAGA
CCCAGGATGGCTGCAGGCCAGGTTTGGGGGGCCTCAACCCTCTCCTGGAGCGCCTGTGAGATGGTCAGCGTGGAGCGCAAGTGCTGGACA
GGTGGCCCGTGTGCCCCACAGGGATGGCTCAGGGGACTGTCCACCTCACCCCTGCACCTCTCAGCCTCTGCCGCCGGGCACCCCCCCCCA

>79126_79126_6_SAMM50-TXNRD2_SAMM50_chr22_44351478_ENST00000350028_TXNRD2_chr22_19918621_ENST00000542719_length(amino acids)=544AA_BP=56
MAAPSVPRPGVCGSCLDLQLRHRGPAFCPQQQTLCPARAALRGSGWRGNHGDCARPAGQRDYDLLVVGGGSGGLACAKEAAQLGRKVAVV
DYVEPSPQGTRWGLGGTCVNVGCIPKKLMHQAALLGGLIQDAPNYGWEVAQPVPHDWRKMAEAVQNHVKSLNWGHRVQLQDRKVKYFNIK
ASFVDEHTVCGVAKGGKEILLSADHIIIATGGRPRYPTHIEGALEYGITSDDIFWLKESPGKTLVVGASYVALECAGFLTGIGLDTTIMM
RSIPLRGFDQQMSSMVIEHMASHGTRFLRGCAPSRVRRLPDGQLQVTWEDSTTGKEDTGTFDTVLWAIGRVPDTRSLNLEKAGVDTSPDT
QKILVDSREATSVPHIYAIGDVVEGRPELTPIAIMAGRLLVQRLFGGSSDLMDYDNVPTTVFTPLEYGCVGLSEEEAVARHGQEHVEVYH
AHYKPLEFTVAGRDASQCYVKMVCLREPPQLVLGLHFLGPNAGEVTQGFALGIKCGASYAQVMRTVGIHPTCSEEVVKLRISKRSGLDPT

--------------------------------------------------------------

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Fusion Gene PPI Analysis for SAMM50-TXNRD2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for SAMM50-TXNRD2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for SAMM50-TXNRD2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource