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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:SAR1A-NODAL (FusionGDB2 ID:79169)

Fusion Gene Summary for SAR1A-NODAL

Fusion gene summary

Fusion gene information	Fusion gene name: SAR1A-NODAL
	Fusion gene ID: 79169
		Hgene	Tgene
	Gene symbol	SAR1A	NODAL
	Gene ID	56681	4838
	Gene name	secretion associated Ras related GTPase 1A	nodal growth differentiation factor
	Synonyms	SAR1\|SARA1\|Sara\|masra2	HTX5
	Cytomap	10q22.1	10q22.1
	Type of gene	protein-coding	protein-coding
	Description	GTP-binding protein SAR1aCOPII-associated small GTPaseSAR1 gene homolog ASAR1 homolog ASAR1a gene homolog 1	nodal homolog
	Modification date	20200313	20200314
	UniProtAcc	.	NODAL
	Ensembl transtripts involved in fusion gene	ENST00000373238, ENST00000373242, ENST00000458634, ENST00000373236, ENST00000373241, ENST00000431664, ENST00000477464,	ENST00000287139,
Fusion gene scores	* DoF score	12 X 8 X 9=864	3 X 1 X 3=9
	# samples	15	4
	** MAII score	log2(15/864*10)=-2.52606881166759 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(4/9*10)=2.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0
Context	PubMed: SAR1A [Title/Abstract] AND NODAL [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	SAR1A(71920760)-NODAL(72195739), # samples:2
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	SAR1A	GO:0090110	cargo loading into COPII-coated vesicle	17499046\|18843296
Tgene	NODAL	GO:0043280	positive regulation of cysteine-type endopeptidase activity involved in apoptotic process	15150278
Tgene	NODAL	GO:0050679	positive regulation of epithelial cell proliferation	21656830
Tgene	NODAL	GO:0060766	negative regulation of androgen receptor signaling pathway	21656830
Tgene	NODAL	GO:1901164	negative regulation of trophoblast cell migration	21356369
Tgene	NODAL	GO:1901383	negative regulation of chorionic trophoblast cell proliferation	15150278

Fusion gene breakpoints across SAR1A (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across NODAL (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	OV	TCGA-04-1356-01A	SAR1A	chr10	71920760	-	NODAL	chr10	72195739	-
ChimerDB4	OV	TCGA-04-1356	SAR1A	chr10	71920759	-	NODAL	chr10	72195739	-

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Fusion Gene ORF analysis for SAR1A-NODAL

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
Frame-shift	ENST00000373238	ENST00000287139	SAR1A	chr10	71920760	-	NODAL	chr10	72195739	-
Frame-shift	ENST00000373238	ENST00000287139	SAR1A	chr10	71920759	-	NODAL	chr10	72195739	-
Frame-shift	ENST00000373242	ENST00000287139	SAR1A	chr10	71920760	-	NODAL	chr10	72195739	-
Frame-shift	ENST00000373242	ENST00000287139	SAR1A	chr10	71920759	-	NODAL	chr10	72195739	-
Frame-shift	ENST00000458634	ENST00000287139	SAR1A	chr10	71920760	-	NODAL	chr10	72195739	-
Frame-shift	ENST00000458634	ENST00000287139	SAR1A	chr10	71920759	-	NODAL	chr10	72195739	-
In-frame	ENST00000373236	ENST00000287139	SAR1A	chr10	71920760	-	NODAL	chr10	72195739	-
In-frame	ENST00000373236	ENST00000287139	SAR1A	chr10	71920759	-	NODAL	chr10	72195739	-
In-frame	ENST00000373241	ENST00000287139	SAR1A	chr10	71920760	-	NODAL	chr10	72195739	-
In-frame	ENST00000373241	ENST00000287139	SAR1A	chr10	71920759	-	NODAL	chr10	72195739	-
In-frame	ENST00000431664	ENST00000287139	SAR1A	chr10	71920760	-	NODAL	chr10	72195739	-
In-frame	ENST00000431664	ENST00000287139	SAR1A	chr10	71920759	-	NODAL	chr10	72195739	-
intron-3CDS	ENST00000477464	ENST00000287139	SAR1A	chr10	71920760	-	NODAL	chr10	72195739	-
intron-3CDS	ENST00000477464	ENST00000287139	SAR1A	chr10	71920759	-	NODAL	chr10	72195739	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000373241	SAR1A	chr10	71920760	-	ENST00000287139	NODAL	chr10	72195739	-	1843	371	127	1221	364
ENST00000431664	SAR1A	chr10	71920760	-	ENST00000287139	NODAL	chr10	72195739	-	1716	244	0	1094	364
ENST00000373236	SAR1A	chr10	71920760	-	ENST00000287139	NODAL	chr10	72195739	-	1716	244	0	1094	364
ENST00000373241	SAR1A	chr10	71920759	-	ENST00000287139	NODAL	chr10	72195739	-	1843	371	127	1221	364
ENST00000431664	SAR1A	chr10	71920759	-	ENST00000287139	NODAL	chr10	72195739	-	1716	244	0	1094	364
ENST00000373236	SAR1A	chr10	71920759	-	ENST00000287139	NODAL	chr10	72195739	-	1716	244	0	1094	364

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000373241	ENST00000287139	SAR1A	chr10	71920760	-	NODAL	chr10	72195739	-	0.060478706	0.9395213
ENST00000431664	ENST00000287139	SAR1A	chr10	71920760	-	NODAL	chr10	72195739	-	0.064308785	0.9356912
ENST00000373236	ENST00000287139	SAR1A	chr10	71920760	-	NODAL	chr10	72195739	-	0.064308785	0.9356912
ENST00000373241	ENST00000287139	SAR1A	chr10	71920759	-	NODAL	chr10	72195739	-	0.060478706	0.9395213
ENST00000431664	ENST00000287139	SAR1A	chr10	71920759	-	NODAL	chr10	72195739	-	0.064308785	0.9356912
ENST00000373236	ENST00000287139	SAR1A	chr10	71920759	-	NODAL	chr10	72195739	-	0.064308785	0.9356912

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Fusion Genomic Features for SAR1A-NODAL

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for SAR1A-NODAL

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr10:71920760/chr10:72195739)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	NODAL NODAL
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	347

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

SAR1A

chr10:71920759

chr10:72195739

ENST00000373238

32_39

199.0

Nucleotide binding

GTP

Hgene

SAR1A

chr10:71920759

chr10:72195739

ENST00000373238

75_78

199.0

Nucleotide binding

GTP

Hgene

SAR1A

chr10:71920759

chr10:72195739

ENST00000373241

32_39

199.0

Nucleotide binding

GTP

Hgene

SAR1A

chr10:71920759

chr10:72195739

ENST00000373241

75_78

199.0

Nucleotide binding

GTP

Hgene

SAR1A

chr10:71920759

chr10:72195739

ENST00000373242

32_39

199.0

Nucleotide binding

GTP

Hgene

SAR1A

chr10:71920759

chr10:72195739

ENST00000373242

75_78

199.0

Nucleotide binding

GTP

Hgene

SAR1A

chr10:71920759

chr10:72195739

ENST00000431664

32_39

916.3333333333334

Nucleotide binding

GTP

Hgene

SAR1A

chr10:71920759

chr10:72195739

ENST00000431664

75_78

916.3333333333334

Nucleotide binding

GTP

Hgene

SAR1A

chr10:71920760

chr10:72195739

ENST00000373238

32_39

199.0

Nucleotide binding

GTP

Hgene

SAR1A

chr10:71920760

chr10:72195739

ENST00000373238

75_78

199.0

Nucleotide binding

GTP

Hgene

SAR1A

chr10:71920760

chr10:72195739

ENST00000373241

32_39

199.0

Nucleotide binding

GTP

Hgene

SAR1A

chr10:71920760

chr10:72195739

ENST00000373241

75_78

199.0

Nucleotide binding

GTP

Hgene

SAR1A

chr10:71920760

chr10:72195739

ENST00000373242

32_39

199.0

Nucleotide binding

GTP

Hgene

SAR1A

chr10:71920760

chr10:72195739

ENST00000373242

75_78

199.0

Nucleotide binding

GTP

Hgene

SAR1A

chr10:71920760

chr10:72195739

ENST00000431664

32_39

916.3333333333334

Nucleotide binding

GTP

Hgene

SAR1A

chr10:71920760

chr10:72195739

ENST00000431664

75_78

916.3333333333334

Nucleotide binding

GTP

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

SAR1A

chr10:71920759

chr10:72195739

ENST00000373238

134_137

199.0

Nucleotide binding

GTP

Hgene

SAR1A

chr10:71920759

chr10:72195739

ENST00000373241

134_137

199.0

Nucleotide binding

GTP

Hgene

SAR1A

chr10:71920759

chr10:72195739

ENST00000373242

134_137

199.0

Nucleotide binding

GTP

Hgene

SAR1A

chr10:71920759

chr10:72195739

ENST00000431664

134_137

916.3333333333334

Nucleotide binding

GTP

Hgene

SAR1A

chr10:71920760

chr10:72195739

ENST00000373238

134_137

199.0

Nucleotide binding

GTP

Hgene

SAR1A

chr10:71920760

chr10:72195739

ENST00000373241

134_137

199.0

Nucleotide binding

GTP

Hgene

SAR1A

chr10:71920760

chr10:72195739

ENST00000373242

134_137

199.0

Nucleotide binding

GTP

Hgene

SAR1A

chr10:71920760

chr10:72195739

ENST00000431664

134_137

916.3333333333334

Nucleotide binding

GTP

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Fusion Gene Sequence for SAR1A-NODAL

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>79169_79169_1_SAR1A-NODAL_SAR1A_chr10_71920759_ENST00000373236_NODAL_chr10_72195739_ENST00000287139_length(transcript)=1716nt_BP=244nt
ATGTCTTTCATCTTTGAGTGGATCTACAATGGCTTCAGCAGTGTGCTCCAGTTCCTAGGACTGTACAAGAAATCTGGAAAACTTGTATTC
TTAGGTTTGGATAATGCAGGCAAAACCACTCTTCTTCACATGCTCAAAGATGACAGATTGGGCCAACATGTTCCAACACTACATCCGACA
TCAGAAGAGCTAACAATTGCTGGAATGACCTTTACAACTTTTGATCTTGGTGGGCACGAGCAAGATGTGGCAGTGGATGGGCAGAACTGG
ACGTTTGCTTTTGACTTCTCCTTCCTGAGCCAACAAGAGGATCTGGCATGGGCTGAGCTCCGGCTGCAGCTGTCCAGCCCTGTGGACCTC
CCCACTGAGGGCTCACTTGCCATTGAGATTTTCCACCAGCCAAAGCCCGACACAGAGCAGGCTTCAGACAGCTGCTTAGAGCGGTTTCAG
ATGGACCTATTCACTGTCACTTTGTCCCAGGTCACCTTTTCCTTGGGCAGCATGGTTTTGGAGGTGACCAGGCCTCTCTCCAAGTGGCTG
AAGCACCCTGGGGCCCTGGAGAAGCAGATGTCCAGGGTAGCTGGAGAGTGCTGGCCGCGGCCCCCCACACCGCCTGCCACCAATGTGCTC
CTTATGCTCTACTCCAACCTCTCGCAGGAGCAGAGGCAGCTGGGTGGGTCCACCTTGCTGTGGGAAGCCGAGAGCTCCTGGCGGGCCCAG
GAGGGACAGCTGTCCTGGGAGTGGGGCAAGAGGCACCGTCGACATCACTTGCCAGACAGAAGTCAACTGTGTCGGAAGGTCAAGTTCCAG
GTGGACTTCAACCTGATCGGATGGGGCTCCTGGATCATCTACCCCAAGCAGTACAACGCCTATCGCTGTGAGGGCGAGTGTCCTAATCCT
GTTGGGGAGGAGTTTCATCCGACCAACCATGCATACATCCAGAGTCTGCTGAAACGTTACCAGCCCCACCGAGTCCCTTCCACTTGTTGT
GCCCCAGTGAAGACCAAGCCGCTGAGCATGCTGTATGTGGATAATGGCAGAGTGCTCCTAGATCACCATAAAGACATGATCGTGGAAGAA
TGTGGGTGCCTCTGATGACATCCTGGAGGGAGACTGGATTTGCCTGCACTCTGGAAGGCTGGGAAACTCCTGGAAGACATGATAACCATC
TAATCCAGTAAGGAGAAACAGAGAGGGGCAAAGTTGCTCTGCCCACCAGAACTGAAGAGGAGGGGCTGCCCACTCTGTAAATGAAGGGCT
CAGTGGAGTCTGGCCAAGCACAGAGGCTGCTGTCAGGAAGAGGGAGGAAGAAGCCTGTGCAGGGGGCTGGCTGGATGTTCTCTTTACTGA
AAAGACAGTGGCAAGGAAAAGCACAAGTGCATGAGTTCTTTACTGGATTTTTTAAAAACCTGTGAACCCCCCGAAACTGTATGTGAAAGT
TGAGACATATGTGCATGTATTTTGGAGGTGGGATGAAGTCACCTATAGCTTTCATGTATTCTCCAAAGTAGTCTGTGTGTGACCTGTCCC
CCTCCCCAAAGATTAAGGATCACTGTATAGATTAAAAAGAGTCCGTCAATCTCATTGCCTCAGGCTGGGTTGGGGGAGCCCCACAGCTTT
CTGGCTGGCCAGTGGCAATCTACTGGCCTTGTCCAGAGGCTCACTGGAGTGGTTCTCTGCTAATGAGCTGTACAACAATAAAGCCATTGT

>79169_79169_1_SAR1A-NODAL_SAR1A_chr10_71920759_ENST00000373236_NODAL_chr10_72195739_ENST00000287139_length(amino acids)=364AA_BP=81
MSFIFEWIYNGFSSVLQFLGLYKKSGKLVFLGLDNAGKTTLLHMLKDDRLGQHVPTLHPTSEELTIAGMTFTTFDLGGHEQDVAVDGQNW
TFAFDFSFLSQQEDLAWAELRLQLSSPVDLPTEGSLAIEIFHQPKPDTEQASDSCLERFQMDLFTVTLSQVTFSLGSMVLEVTRPLSKWL
KHPGALEKQMSRVAGECWPRPPTPPATNVLLMLYSNLSQEQRQLGGSTLLWEAESSWRAQEGQLSWEWGKRHRRHHLPDRSQLCRKVKFQ
VDFNLIGWGSWIIYPKQYNAYRCEGECPNPVGEEFHPTNHAYIQSLLKRYQPHRVPSTCCAPVKTKPLSMLYVDNGRVLLDHHKDMIVEE

--------------------------------------------------------------
>79169_79169_2_SAR1A-NODAL_SAR1A_chr10_71920759_ENST00000373241_NODAL_chr10_72195739_ENST00000287139_length(transcript)=1843nt_BP=371nt
GGGTGTGACGTACATCCGGCGAGTAGCTGGCGGTCCCGGGTGCTGCTGGTTAGTGTGCTCTGAGGGAGGGTCCGAGCCAGCCGCTGTTTT
GCCGGAGGAGCCCCTCAGGCCGTAGTAAGCATTAATAATGTCTTTCATCTTTGAGTGGATCTACAATGGCTTCAGCAGTGTGCTCCAGTT
CCTAGGACTGTACAAGAAATCTGGAAAACTTGTATTCTTAGGTTTGGATAATGCAGGCAAAACCACTCTTCTTCACATGCTCAAAGATGA
CAGATTGGGCCAACATGTTCCAACACTACATCCGACATCAGAAGAGCTAACAATTGCTGGAATGACCTTTACAACTTTTGATCTTGGTGG
GCACGAGCAAGATGTGGCAGTGGATGGGCAGAACTGGACGTTTGCTTTTGACTTCTCCTTCCTGAGCCAACAAGAGGATCTGGCATGGGC
TGAGCTCCGGCTGCAGCTGTCCAGCCCTGTGGACCTCCCCACTGAGGGCTCACTTGCCATTGAGATTTTCCACCAGCCAAAGCCCGACAC
AGAGCAGGCTTCAGACAGCTGCTTAGAGCGGTTTCAGATGGACCTATTCACTGTCACTTTGTCCCAGGTCACCTTTTCCTTGGGCAGCAT
GGTTTTGGAGGTGACCAGGCCTCTCTCCAAGTGGCTGAAGCACCCTGGGGCCCTGGAGAAGCAGATGTCCAGGGTAGCTGGAGAGTGCTG
GCCGCGGCCCCCCACACCGCCTGCCACCAATGTGCTCCTTATGCTCTACTCCAACCTCTCGCAGGAGCAGAGGCAGCTGGGTGGGTCCAC
CTTGCTGTGGGAAGCCGAGAGCTCCTGGCGGGCCCAGGAGGGACAGCTGTCCTGGGAGTGGGGCAAGAGGCACCGTCGACATCACTTGCC
AGACAGAAGTCAACTGTGTCGGAAGGTCAAGTTCCAGGTGGACTTCAACCTGATCGGATGGGGCTCCTGGATCATCTACCCCAAGCAGTA
CAACGCCTATCGCTGTGAGGGCGAGTGTCCTAATCCTGTTGGGGAGGAGTTTCATCCGACCAACCATGCATACATCCAGAGTCTGCTGAA
ACGTTACCAGCCCCACCGAGTCCCTTCCACTTGTTGTGCCCCAGTGAAGACCAAGCCGCTGAGCATGCTGTATGTGGATAATGGCAGAGT
GCTCCTAGATCACCATAAAGACATGATCGTGGAAGAATGTGGGTGCCTCTGATGACATCCTGGAGGGAGACTGGATTTGCCTGCACTCTG
GAAGGCTGGGAAACTCCTGGAAGACATGATAACCATCTAATCCAGTAAGGAGAAACAGAGAGGGGCAAAGTTGCTCTGCCCACCAGAACT
GAAGAGGAGGGGCTGCCCACTCTGTAAATGAAGGGCTCAGTGGAGTCTGGCCAAGCACAGAGGCTGCTGTCAGGAAGAGGGAGGAAGAAG
CCTGTGCAGGGGGCTGGCTGGATGTTCTCTTTACTGAAAAGACAGTGGCAAGGAAAAGCACAAGTGCATGAGTTCTTTACTGGATTTTTT
AAAAACCTGTGAACCCCCCGAAACTGTATGTGAAAGTTGAGACATATGTGCATGTATTTTGGAGGTGGGATGAAGTCACCTATAGCTTTC
ATGTATTCTCCAAAGTAGTCTGTGTGTGACCTGTCCCCCTCCCCAAAGATTAAGGATCACTGTATAGATTAAAAAGAGTCCGTCAATCTC
ATTGCCTCAGGCTGGGTTGGGGGAGCCCCACAGCTTTCTGGCTGGCCAGTGGCAATCTACTGGCCTTGTCCAGAGGCTCACTGGAGTGGT

>79169_79169_2_SAR1A-NODAL_SAR1A_chr10_71920759_ENST00000373241_NODAL_chr10_72195739_ENST00000287139_length(amino acids)=364AA_BP=81
MSFIFEWIYNGFSSVLQFLGLYKKSGKLVFLGLDNAGKTTLLHMLKDDRLGQHVPTLHPTSEELTIAGMTFTTFDLGGHEQDVAVDGQNW
TFAFDFSFLSQQEDLAWAELRLQLSSPVDLPTEGSLAIEIFHQPKPDTEQASDSCLERFQMDLFTVTLSQVTFSLGSMVLEVTRPLSKWL
KHPGALEKQMSRVAGECWPRPPTPPATNVLLMLYSNLSQEQRQLGGSTLLWEAESSWRAQEGQLSWEWGKRHRRHHLPDRSQLCRKVKFQ
VDFNLIGWGSWIIYPKQYNAYRCEGECPNPVGEEFHPTNHAYIQSLLKRYQPHRVPSTCCAPVKTKPLSMLYVDNGRVLLDHHKDMIVEE

--------------------------------------------------------------
>79169_79169_3_SAR1A-NODAL_SAR1A_chr10_71920759_ENST00000431664_NODAL_chr10_72195739_ENST00000287139_length(transcript)=1716nt_BP=244nt
ATGTCTTTCATCTTTGAGTGGATCTACAATGGCTTCAGCAGTGTGCTCCAGTTCCTAGGACTGTACAAGAAATCTGGAAAACTTGTATTC
TTAGGTTTGGATAATGCAGGCAAAACCACTCTTCTTCACATGCTCAAAGATGACAGATTGGGCCAACATGTTCCAACACTACATCCGACA
TCAGAAGAGCTAACAATTGCTGGAATGACCTTTACAACTTTTGATCTTGGTGGGCACGAGCAAGATGTGGCAGTGGATGGGCAGAACTGG
ACGTTTGCTTTTGACTTCTCCTTCCTGAGCCAACAAGAGGATCTGGCATGGGCTGAGCTCCGGCTGCAGCTGTCCAGCCCTGTGGACCTC
CCCACTGAGGGCTCACTTGCCATTGAGATTTTCCACCAGCCAAAGCCCGACACAGAGCAGGCTTCAGACAGCTGCTTAGAGCGGTTTCAG
ATGGACCTATTCACTGTCACTTTGTCCCAGGTCACCTTTTCCTTGGGCAGCATGGTTTTGGAGGTGACCAGGCCTCTCTCCAAGTGGCTG
AAGCACCCTGGGGCCCTGGAGAAGCAGATGTCCAGGGTAGCTGGAGAGTGCTGGCCGCGGCCCCCCACACCGCCTGCCACCAATGTGCTC
CTTATGCTCTACTCCAACCTCTCGCAGGAGCAGAGGCAGCTGGGTGGGTCCACCTTGCTGTGGGAAGCCGAGAGCTCCTGGCGGGCCCAG
GAGGGACAGCTGTCCTGGGAGTGGGGCAAGAGGCACCGTCGACATCACTTGCCAGACAGAAGTCAACTGTGTCGGAAGGTCAAGTTCCAG
GTGGACTTCAACCTGATCGGATGGGGCTCCTGGATCATCTACCCCAAGCAGTACAACGCCTATCGCTGTGAGGGCGAGTGTCCTAATCCT
GTTGGGGAGGAGTTTCATCCGACCAACCATGCATACATCCAGAGTCTGCTGAAACGTTACCAGCCCCACCGAGTCCCTTCCACTTGTTGT
GCCCCAGTGAAGACCAAGCCGCTGAGCATGCTGTATGTGGATAATGGCAGAGTGCTCCTAGATCACCATAAAGACATGATCGTGGAAGAA
TGTGGGTGCCTCTGATGACATCCTGGAGGGAGACTGGATTTGCCTGCACTCTGGAAGGCTGGGAAACTCCTGGAAGACATGATAACCATC
TAATCCAGTAAGGAGAAACAGAGAGGGGCAAAGTTGCTCTGCCCACCAGAACTGAAGAGGAGGGGCTGCCCACTCTGTAAATGAAGGGCT
CAGTGGAGTCTGGCCAAGCACAGAGGCTGCTGTCAGGAAGAGGGAGGAAGAAGCCTGTGCAGGGGGCTGGCTGGATGTTCTCTTTACTGA
AAAGACAGTGGCAAGGAAAAGCACAAGTGCATGAGTTCTTTACTGGATTTTTTAAAAACCTGTGAACCCCCCGAAACTGTATGTGAAAGT
TGAGACATATGTGCATGTATTTTGGAGGTGGGATGAAGTCACCTATAGCTTTCATGTATTCTCCAAAGTAGTCTGTGTGTGACCTGTCCC
CCTCCCCAAAGATTAAGGATCACTGTATAGATTAAAAAGAGTCCGTCAATCTCATTGCCTCAGGCTGGGTTGGGGGAGCCCCACAGCTTT
CTGGCTGGCCAGTGGCAATCTACTGGCCTTGTCCAGAGGCTCACTGGAGTGGTTCTCTGCTAATGAGCTGTACAACAATAAAGCCATTGT

>79169_79169_3_SAR1A-NODAL_SAR1A_chr10_71920759_ENST00000431664_NODAL_chr10_72195739_ENST00000287139_length(amino acids)=364AA_BP=81
MSFIFEWIYNGFSSVLQFLGLYKKSGKLVFLGLDNAGKTTLLHMLKDDRLGQHVPTLHPTSEELTIAGMTFTTFDLGGHEQDVAVDGQNW
TFAFDFSFLSQQEDLAWAELRLQLSSPVDLPTEGSLAIEIFHQPKPDTEQASDSCLERFQMDLFTVTLSQVTFSLGSMVLEVTRPLSKWL
KHPGALEKQMSRVAGECWPRPPTPPATNVLLMLYSNLSQEQRQLGGSTLLWEAESSWRAQEGQLSWEWGKRHRRHHLPDRSQLCRKVKFQ
VDFNLIGWGSWIIYPKQYNAYRCEGECPNPVGEEFHPTNHAYIQSLLKRYQPHRVPSTCCAPVKTKPLSMLYVDNGRVLLDHHKDMIVEE

--------------------------------------------------------------
>79169_79169_4_SAR1A-NODAL_SAR1A_chr10_71920760_ENST00000373236_NODAL_chr10_72195739_ENST00000287139_length(transcript)=1716nt_BP=244nt
ATGTCTTTCATCTTTGAGTGGATCTACAATGGCTTCAGCAGTGTGCTCCAGTTCCTAGGACTGTACAAGAAATCTGGAAAACTTGTATTC
TTAGGTTTGGATAATGCAGGCAAAACCACTCTTCTTCACATGCTCAAAGATGACAGATTGGGCCAACATGTTCCAACACTACATCCGACA
TCAGAAGAGCTAACAATTGCTGGAATGACCTTTACAACTTTTGATCTTGGTGGGCACGAGCAAGATGTGGCAGTGGATGGGCAGAACTGG
ACGTTTGCTTTTGACTTCTCCTTCCTGAGCCAACAAGAGGATCTGGCATGGGCTGAGCTCCGGCTGCAGCTGTCCAGCCCTGTGGACCTC
CCCACTGAGGGCTCACTTGCCATTGAGATTTTCCACCAGCCAAAGCCCGACACAGAGCAGGCTTCAGACAGCTGCTTAGAGCGGTTTCAG
ATGGACCTATTCACTGTCACTTTGTCCCAGGTCACCTTTTCCTTGGGCAGCATGGTTTTGGAGGTGACCAGGCCTCTCTCCAAGTGGCTG
AAGCACCCTGGGGCCCTGGAGAAGCAGATGTCCAGGGTAGCTGGAGAGTGCTGGCCGCGGCCCCCCACACCGCCTGCCACCAATGTGCTC
CTTATGCTCTACTCCAACCTCTCGCAGGAGCAGAGGCAGCTGGGTGGGTCCACCTTGCTGTGGGAAGCCGAGAGCTCCTGGCGGGCCCAG
GAGGGACAGCTGTCCTGGGAGTGGGGCAAGAGGCACCGTCGACATCACTTGCCAGACAGAAGTCAACTGTGTCGGAAGGTCAAGTTCCAG
GTGGACTTCAACCTGATCGGATGGGGCTCCTGGATCATCTACCCCAAGCAGTACAACGCCTATCGCTGTGAGGGCGAGTGTCCTAATCCT
GTTGGGGAGGAGTTTCATCCGACCAACCATGCATACATCCAGAGTCTGCTGAAACGTTACCAGCCCCACCGAGTCCCTTCCACTTGTTGT
GCCCCAGTGAAGACCAAGCCGCTGAGCATGCTGTATGTGGATAATGGCAGAGTGCTCCTAGATCACCATAAAGACATGATCGTGGAAGAA
TGTGGGTGCCTCTGATGACATCCTGGAGGGAGACTGGATTTGCCTGCACTCTGGAAGGCTGGGAAACTCCTGGAAGACATGATAACCATC
TAATCCAGTAAGGAGAAACAGAGAGGGGCAAAGTTGCTCTGCCCACCAGAACTGAAGAGGAGGGGCTGCCCACTCTGTAAATGAAGGGCT
CAGTGGAGTCTGGCCAAGCACAGAGGCTGCTGTCAGGAAGAGGGAGGAAGAAGCCTGTGCAGGGGGCTGGCTGGATGTTCTCTTTACTGA
AAAGACAGTGGCAAGGAAAAGCACAAGTGCATGAGTTCTTTACTGGATTTTTTAAAAACCTGTGAACCCCCCGAAACTGTATGTGAAAGT
TGAGACATATGTGCATGTATTTTGGAGGTGGGATGAAGTCACCTATAGCTTTCATGTATTCTCCAAAGTAGTCTGTGTGTGACCTGTCCC
CCTCCCCAAAGATTAAGGATCACTGTATAGATTAAAAAGAGTCCGTCAATCTCATTGCCTCAGGCTGGGTTGGGGGAGCCCCACAGCTTT
CTGGCTGGCCAGTGGCAATCTACTGGCCTTGTCCAGAGGCTCACTGGAGTGGTTCTCTGCTAATGAGCTGTACAACAATAAAGCCATTGT

>79169_79169_4_SAR1A-NODAL_SAR1A_chr10_71920760_ENST00000373236_NODAL_chr10_72195739_ENST00000287139_length(amino acids)=364AA_BP=81
MSFIFEWIYNGFSSVLQFLGLYKKSGKLVFLGLDNAGKTTLLHMLKDDRLGQHVPTLHPTSEELTIAGMTFTTFDLGGHEQDVAVDGQNW
TFAFDFSFLSQQEDLAWAELRLQLSSPVDLPTEGSLAIEIFHQPKPDTEQASDSCLERFQMDLFTVTLSQVTFSLGSMVLEVTRPLSKWL
KHPGALEKQMSRVAGECWPRPPTPPATNVLLMLYSNLSQEQRQLGGSTLLWEAESSWRAQEGQLSWEWGKRHRRHHLPDRSQLCRKVKFQ
VDFNLIGWGSWIIYPKQYNAYRCEGECPNPVGEEFHPTNHAYIQSLLKRYQPHRVPSTCCAPVKTKPLSMLYVDNGRVLLDHHKDMIVEE

--------------------------------------------------------------
>79169_79169_5_SAR1A-NODAL_SAR1A_chr10_71920760_ENST00000373241_NODAL_chr10_72195739_ENST00000287139_length(transcript)=1843nt_BP=371nt
GGGTGTGACGTACATCCGGCGAGTAGCTGGCGGTCCCGGGTGCTGCTGGTTAGTGTGCTCTGAGGGAGGGTCCGAGCCAGCCGCTGTTTT
GCCGGAGGAGCCCCTCAGGCCGTAGTAAGCATTAATAATGTCTTTCATCTTTGAGTGGATCTACAATGGCTTCAGCAGTGTGCTCCAGTT
CCTAGGACTGTACAAGAAATCTGGAAAACTTGTATTCTTAGGTTTGGATAATGCAGGCAAAACCACTCTTCTTCACATGCTCAAAGATGA
CAGATTGGGCCAACATGTTCCAACACTACATCCGACATCAGAAGAGCTAACAATTGCTGGAATGACCTTTACAACTTTTGATCTTGGTGG
GCACGAGCAAGATGTGGCAGTGGATGGGCAGAACTGGACGTTTGCTTTTGACTTCTCCTTCCTGAGCCAACAAGAGGATCTGGCATGGGC
TGAGCTCCGGCTGCAGCTGTCCAGCCCTGTGGACCTCCCCACTGAGGGCTCACTTGCCATTGAGATTTTCCACCAGCCAAAGCCCGACAC
AGAGCAGGCTTCAGACAGCTGCTTAGAGCGGTTTCAGATGGACCTATTCACTGTCACTTTGTCCCAGGTCACCTTTTCCTTGGGCAGCAT
GGTTTTGGAGGTGACCAGGCCTCTCTCCAAGTGGCTGAAGCACCCTGGGGCCCTGGAGAAGCAGATGTCCAGGGTAGCTGGAGAGTGCTG
GCCGCGGCCCCCCACACCGCCTGCCACCAATGTGCTCCTTATGCTCTACTCCAACCTCTCGCAGGAGCAGAGGCAGCTGGGTGGGTCCAC
CTTGCTGTGGGAAGCCGAGAGCTCCTGGCGGGCCCAGGAGGGACAGCTGTCCTGGGAGTGGGGCAAGAGGCACCGTCGACATCACTTGCC
AGACAGAAGTCAACTGTGTCGGAAGGTCAAGTTCCAGGTGGACTTCAACCTGATCGGATGGGGCTCCTGGATCATCTACCCCAAGCAGTA
CAACGCCTATCGCTGTGAGGGCGAGTGTCCTAATCCTGTTGGGGAGGAGTTTCATCCGACCAACCATGCATACATCCAGAGTCTGCTGAA
ACGTTACCAGCCCCACCGAGTCCCTTCCACTTGTTGTGCCCCAGTGAAGACCAAGCCGCTGAGCATGCTGTATGTGGATAATGGCAGAGT
GCTCCTAGATCACCATAAAGACATGATCGTGGAAGAATGTGGGTGCCTCTGATGACATCCTGGAGGGAGACTGGATTTGCCTGCACTCTG
GAAGGCTGGGAAACTCCTGGAAGACATGATAACCATCTAATCCAGTAAGGAGAAACAGAGAGGGGCAAAGTTGCTCTGCCCACCAGAACT
GAAGAGGAGGGGCTGCCCACTCTGTAAATGAAGGGCTCAGTGGAGTCTGGCCAAGCACAGAGGCTGCTGTCAGGAAGAGGGAGGAAGAAG
CCTGTGCAGGGGGCTGGCTGGATGTTCTCTTTACTGAAAAGACAGTGGCAAGGAAAAGCACAAGTGCATGAGTTCTTTACTGGATTTTTT
AAAAACCTGTGAACCCCCCGAAACTGTATGTGAAAGTTGAGACATATGTGCATGTATTTTGGAGGTGGGATGAAGTCACCTATAGCTTTC
ATGTATTCTCCAAAGTAGTCTGTGTGTGACCTGTCCCCCTCCCCAAAGATTAAGGATCACTGTATAGATTAAAAAGAGTCCGTCAATCTC
ATTGCCTCAGGCTGGGTTGGGGGAGCCCCACAGCTTTCTGGCTGGCCAGTGGCAATCTACTGGCCTTGTCCAGAGGCTCACTGGAGTGGT

>79169_79169_5_SAR1A-NODAL_SAR1A_chr10_71920760_ENST00000373241_NODAL_chr10_72195739_ENST00000287139_length(amino acids)=364AA_BP=81
MSFIFEWIYNGFSSVLQFLGLYKKSGKLVFLGLDNAGKTTLLHMLKDDRLGQHVPTLHPTSEELTIAGMTFTTFDLGGHEQDVAVDGQNW
TFAFDFSFLSQQEDLAWAELRLQLSSPVDLPTEGSLAIEIFHQPKPDTEQASDSCLERFQMDLFTVTLSQVTFSLGSMVLEVTRPLSKWL
KHPGALEKQMSRVAGECWPRPPTPPATNVLLMLYSNLSQEQRQLGGSTLLWEAESSWRAQEGQLSWEWGKRHRRHHLPDRSQLCRKVKFQ
VDFNLIGWGSWIIYPKQYNAYRCEGECPNPVGEEFHPTNHAYIQSLLKRYQPHRVPSTCCAPVKTKPLSMLYVDNGRVLLDHHKDMIVEE

--------------------------------------------------------------
>79169_79169_6_SAR1A-NODAL_SAR1A_chr10_71920760_ENST00000431664_NODAL_chr10_72195739_ENST00000287139_length(transcript)=1716nt_BP=244nt
ATGTCTTTCATCTTTGAGTGGATCTACAATGGCTTCAGCAGTGTGCTCCAGTTCCTAGGACTGTACAAGAAATCTGGAAAACTTGTATTC
TTAGGTTTGGATAATGCAGGCAAAACCACTCTTCTTCACATGCTCAAAGATGACAGATTGGGCCAACATGTTCCAACACTACATCCGACA
TCAGAAGAGCTAACAATTGCTGGAATGACCTTTACAACTTTTGATCTTGGTGGGCACGAGCAAGATGTGGCAGTGGATGGGCAGAACTGG
ACGTTTGCTTTTGACTTCTCCTTCCTGAGCCAACAAGAGGATCTGGCATGGGCTGAGCTCCGGCTGCAGCTGTCCAGCCCTGTGGACCTC
CCCACTGAGGGCTCACTTGCCATTGAGATTTTCCACCAGCCAAAGCCCGACACAGAGCAGGCTTCAGACAGCTGCTTAGAGCGGTTTCAG
ATGGACCTATTCACTGTCACTTTGTCCCAGGTCACCTTTTCCTTGGGCAGCATGGTTTTGGAGGTGACCAGGCCTCTCTCCAAGTGGCTG
AAGCACCCTGGGGCCCTGGAGAAGCAGATGTCCAGGGTAGCTGGAGAGTGCTGGCCGCGGCCCCCCACACCGCCTGCCACCAATGTGCTC
CTTATGCTCTACTCCAACCTCTCGCAGGAGCAGAGGCAGCTGGGTGGGTCCACCTTGCTGTGGGAAGCCGAGAGCTCCTGGCGGGCCCAG
GAGGGACAGCTGTCCTGGGAGTGGGGCAAGAGGCACCGTCGACATCACTTGCCAGACAGAAGTCAACTGTGTCGGAAGGTCAAGTTCCAG
GTGGACTTCAACCTGATCGGATGGGGCTCCTGGATCATCTACCCCAAGCAGTACAACGCCTATCGCTGTGAGGGCGAGTGTCCTAATCCT
GTTGGGGAGGAGTTTCATCCGACCAACCATGCATACATCCAGAGTCTGCTGAAACGTTACCAGCCCCACCGAGTCCCTTCCACTTGTTGT
GCCCCAGTGAAGACCAAGCCGCTGAGCATGCTGTATGTGGATAATGGCAGAGTGCTCCTAGATCACCATAAAGACATGATCGTGGAAGAA
TGTGGGTGCCTCTGATGACATCCTGGAGGGAGACTGGATTTGCCTGCACTCTGGAAGGCTGGGAAACTCCTGGAAGACATGATAACCATC
TAATCCAGTAAGGAGAAACAGAGAGGGGCAAAGTTGCTCTGCCCACCAGAACTGAAGAGGAGGGGCTGCCCACTCTGTAAATGAAGGGCT
CAGTGGAGTCTGGCCAAGCACAGAGGCTGCTGTCAGGAAGAGGGAGGAAGAAGCCTGTGCAGGGGGCTGGCTGGATGTTCTCTTTACTGA
AAAGACAGTGGCAAGGAAAAGCACAAGTGCATGAGTTCTTTACTGGATTTTTTAAAAACCTGTGAACCCCCCGAAACTGTATGTGAAAGT
TGAGACATATGTGCATGTATTTTGGAGGTGGGATGAAGTCACCTATAGCTTTCATGTATTCTCCAAAGTAGTCTGTGTGTGACCTGTCCC
CCTCCCCAAAGATTAAGGATCACTGTATAGATTAAAAAGAGTCCGTCAATCTCATTGCCTCAGGCTGGGTTGGGGGAGCCCCACAGCTTT
CTGGCTGGCCAGTGGCAATCTACTGGCCTTGTCCAGAGGCTCACTGGAGTGGTTCTCTGCTAATGAGCTGTACAACAATAAAGCCATTGT

>79169_79169_6_SAR1A-NODAL_SAR1A_chr10_71920760_ENST00000431664_NODAL_chr10_72195739_ENST00000287139_length(amino acids)=364AA_BP=81
MSFIFEWIYNGFSSVLQFLGLYKKSGKLVFLGLDNAGKTTLLHMLKDDRLGQHVPTLHPTSEELTIAGMTFTTFDLGGHEQDVAVDGQNW
TFAFDFSFLSQQEDLAWAELRLQLSSPVDLPTEGSLAIEIFHQPKPDTEQASDSCLERFQMDLFTVTLSQVTFSLGSMVLEVTRPLSKWL
KHPGALEKQMSRVAGECWPRPPTPPATNVLLMLYSNLSQEQRQLGGSTLLWEAESSWRAQEGQLSWEWGKRHRRHHLPDRSQLCRKVKFQ
VDFNLIGWGSWIIYPKQYNAYRCEGECPNPVGEEFHPTNHAYIQSLLKRYQPHRVPSTCCAPVKTKPLSMLYVDNGRVLLDHHKDMIVEE

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for SAR1A-NODAL

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for SAR1A-NODAL

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for SAR1A-NODAL

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source