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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:SARS-LPCAT4 (FusionGDB2 ID:79210)

Fusion Gene Summary for SARS-LPCAT4

check button Fusion gene summary
Fusion gene informationFusion gene name: SARS-LPCAT4
Fusion gene ID: 79210
HgeneTgene
Gene symbol

SARS

LPCAT4

Gene ID

54938

254531

Gene nameseryl-tRNA synthetase 2, mitochondriallysophosphatidylcholine acyltransferase 4
SynonymsSARS|SARSM|SERS|SYS|SerRS|SerRSmt|mtSerRSAGPAT7|AYTL3|LPAAT-eta|LPEAT2
Cytomap

19q13.2

15q14

Type of geneprotein-codingprotein-coding
Descriptionserine--tRNA ligase, mitochondrialmitochondrial seryl-tRNA synthetaseserine tRNA ligase 2, mitochondrialseryl-tRNA synthetase, mitochondrialseryl-tRNA(Ser/Sec) synthetaselysophospholipid acyltransferase LPCAT41-AGP acyltransferase 71-AGPAT 71-acylglycerol-3-phosphate O-acyltransferase 7 (lysophosphatidic acid acyltransferase, eta)1-acylglycerophosphocholine O-acyltransferase1-acylglycerophosphoserine O-acyltransferas
Modification date2020031320200313
UniProtAcc.

Q643R3

Ensembl transtripts involved in fusion geneENST00000234677, ENST00000369923, 
ENST00000468588, 		ENST00000562431, 
ENST00000314891, 
Fusion gene scores* DoF score4 X 7 X 3=842 X 2 X 2=8
# samples 52
** MAII scorelog2(5/84*10)=-0.748461233004036
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(2/8*10)=1.32192809488736
Context

PubMed: SARS [Title/Abstract] AND LPCAT4 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointSARS(109778053)-LPCAT4(34657902), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneLPCAT4

GO:0006644

phospholipid metabolic process

18458083


check buttonFusion gene breakpoints across SARS (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across LPCAT4 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4ESCATCGA-VR-A8EQSARSchr1

109778053

+LPCAT4chr15

34657902

-


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Fusion Gene ORF analysis for SARS-LPCAT4

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000234677ENST00000562431SARSchr1

109778053

+LPCAT4chr15

34657902

-
5CDS-5UTRENST00000369923ENST00000562431SARSchr1

109778053

+LPCAT4chr15

34657902

-
In-frameENST00000234677ENST00000314891SARSchr1

109778053

+LPCAT4chr15

34657902

-
In-frameENST00000369923ENST00000314891SARSchr1

109778053

+LPCAT4chr15

34657902

-
intron-3CDSENST00000468588ENST00000314891SARSchr1

109778053

+LPCAT4chr15

34657902

-
intron-5UTRENST00000468588ENST00000562431SARSchr1

109778053

+LPCAT4chr15

34657902

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000234677SARSchr1109778053+ENST00000314891LPCAT4chr1534657902-27271044482504818
ENST00000369923SARSchr1109778053+ENST00000314891LPCAT4chr1534657902-2663980112440809

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000234677ENST00000314891SARSchr1109778053+LPCAT4chr1534657902-0.0034438090.99655616
ENST00000369923ENST00000314891SARSchr1109778053+LPCAT4chr1534657902-0.0034478240.9965521

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Fusion Genomic Features for SARS-LPCAT4


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for SARS-LPCAT4


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:109778053/chr15:34657902)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.LPCAT4

Q643R3

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Displays acyl-CoA-dependent lysophospholipid acyltransferase activity with a subset of lysophospholipids as substrates; converts lysophosphatidylethanolamine to phosphatidylethanolamine, lysophosphatidylcholine to phosphatidycholine, 1-alkenyl-lysophatidylethanolamine to 1-alkenyl-phosphatidylethanolamine, lysophosphatidylglycerol and alkyl-lysophosphatidylcholine to phosphatidylglycerol and alkyl-phosphatidylcholine, respectively. In contrast, has no lysophosphatidylinositol, glycerol-3-phosphate, diacylglycerol or lysophosphatidic acid acyltransferase activity. Prefers long chain acyl-CoAs (C16, C18) as acyl donors. {ECO:0000269|PubMed:18458083}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSARSchr1:109778053chr15:34657902ENST00000234677+711302_304323515.0Nucleotide bindingATP
HgeneSARSchr1:109778053chr15:34657902ENST00000234677+711318_321323515.0Nucleotide bindingATP
TgeneLPCAT4chr1:109778053chr15:34657902ENST00000314891014129_13438525.0MotifNote=HXXXXD motif
TgeneLPCAT4chr1:109778053chr15:34657902ENST0000031489101440_6238525.0TransmembraneHelical
TgeneLPCAT4chr1:109778053chr15:34657902ENST0000031489101487_10738525.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSARSchr1:109778053chr15:34657902ENST00000234677+711482_494323515.0MotifNuclear localization signal
HgeneSARSchr1:109778053chr15:34657902ENST00000234677+711391_394323515.0Nucleotide bindingATP


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Fusion Gene Sequence for SARS-LPCAT4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>79210_79210_1_SARS-LPCAT4_SARS_chr1_109778053_ENST00000234677_LPCAT4_chr15_34657902_ENST00000314891_length(transcript)=2727nt_BP=1044nt
GCAGTGCGGCGGTCACAGGCTGAGTGCTGCGGCGCGATCCTTGCTTCCCTGAGCGTTGGCCCGGGAGGAAAGAAGATGGTGCTGGATCTG
GATTTGTTTCGGGTGGATAAAGGAGGGGACCCAGCCCTCATCCGAGAGACGCAGGAGAAGCGCTTCAAGGACCCGGGACTAGTGGACCAG
CTGGTGAAGGCAGACAGCGAGTGGCGACGATGTAGATTTCGGGCAGACAACTTGAACAAGCTGAAGAACCTATGCAGCAAGACAATCGGA
GAGAAAATGAAGAAAAAAGAGCCAGTGGGAGATGATGAGTCTGTCCCAGAGAATGTGCTGAGTTTCGATGACCTTACTGCAGACGCTTTA
GCTAACCTGAAAGTCTCACAAATCAAAAAAGTCCGACTCCTCATTGATGAAGCCATCCTGAAGTGTGACGCGGAGCGGATAAAGTTGGAA
GCAGAGCGGTTTGAGAACCTCCGAGAGATTGGGAACCTTCTGCACCCTTCTGTACCCATCAGTAACGATGAGGATGTGGACAACAAAGTA
GAGAGGATTTGGGGTGATTGTACAGTCAGGAAGAAGTACTCTCATGTGGACCTGGTGGTGATGGTAGATGGCTTTGAAGGCGAAAAGGGG
GCCGTGGTGGCTGGGAGTCGAGGGTACTTCTTGAAGGGGGTCCTGGTGTTCCTGGAACAGGCTCTCATCCAGTATGCCCTTCGCACCTTG
GGAAGTCGGGGCTACATTCCCATTTATACCCCCTTTTTCATGAGGAAGGAGGTCATGCAGGAGGTGGCACAGCTCAGCCAGTTTGATGAA
GAACTTTATAAGGTGATTGGCAAAGGCAGTGAAAAGTCTGATGACAACTCCTATGATGAGAAGTACCTGATTGCCACCTCAGAGCAGCCC
ATTGCTGCCCTGCACCGGGATGAGTGGCTCCGGCCGGAGGACCTGCCCATCAAGTATGCTGGCCTGTCTACCTGCTTCCGTCAGGAGGTG
GGCTCCCATGGCCGTGACACCCGTGGCATCTTCCGAGTCCATCAGTTTGAGAAGTTCTGCCTCCTGGGGGCATTGCTGGCCCCCATCCGA
GTGCTTCTGGCCTTTATCGTCCTCTTTCTCCTCTGGCCCTTTGCCTGGCTTCAAGTGGCCGGTCTTAGTGAGGAGCAGCTTCAGGAGCCA
ATTACAGGATGGAGGAAGACTGTGTGCCACAACGGGGTGCTAGGCCTGAGCCGCCTGCTGTTTTTCCTGCTGGGCTTCCTCCGGATTCGC
GTTCGTGGCCAGCGAGCCTCTCGCCTTCAAGCCCCTGTCCTTGTTGCTGCCCCACACTCCACTTTCTTTGACCCCATTGTTCTGCTGCCC
TGTGACCTGCCCAAAGTTGTGTCCCGAGCTGAGAACCTTTCCGTTCCTGTCATTGGAGCCCTTCTTCGATTCAACCAAGCCATCCTGGTA
TCCCGGCATGACCCGGCTTCTCGACGCAGAGTGGTGGAGGAGGTCCGAAGGCGGGCCACCTCAGGAGGCAAGTGGCCGCAGGTGCTATTC
TTTCCTGAGGGCACCTGTTCCAACAAGAAGGCTTTGCTTAAGTTCAAACCAGGAGCCTTCATCGCAGGGGTGCCTGTGCAGCCTGTCCTC
ATCCGCTACCCCAACAGTCTGGACACCACCAGCTGGGCATGGAGGGGTCCTGGAGTACTCAAAGTCCTCTGGCTCACAGCCTCTCAGCCC
TGCAGCATTGTGGATGTGGAGTTCCTTCCTGTGTATCACCCCAGCCCTGAGGAGAGCAGGGACCCCACCCTCTATGCCAACAATGTTCAG
AGGGTCATGGCACAGGCTCTGGGCATTCCAGCCACCGAATGTGAGTTTGTAGGGAGCTTACCTGTGATTGTGGTGGGCCGGCTGAAGGTG
GCGTTGGAACCACAGCTCTGGGAACTGGGAAAAGTGCTTCGGAAGGCTGGGCTGTCCGCTGGCTATGTGGACGCTGGGGCAGAGCCAGGC
CGGAGTCGAATGATCAGCCAGGAAGAGTTTGCCAGGCAGCTACAGCTCTCTGATCCTCAGACGGTGGCTGGTGCCTTTGGCTACTTCCAG
CAGGATACCAAGGGTTTGGTGGACTTCCGAGATGTGGCCCTTGCACTAGCAGCTCTGGATGGGGGCAGGAGCCTGGAAGAGCTAACTCGT
CTGGCCTTTGAGCTCTTTGCTGAAGAGCAAGCAGAGGGTCCCAACCGCCTGCTGTACAAAGACGGCTTCAGCACCATCCTGCACCTGCTG
CTGGGTTCACCCCACCCTGCTGCCACAGCTTTGCATGCTGAGCTGTGCCAGGCAGGATCCAGCCAAGGCCTCTCCCTCTGTCAGTTCCAG
AACTTCTCCCTCCATGACCCACTCTATGGGAAACTCTTCAGCACCTACCTGCGCCCCCCACACACCTCTCGAGGCACCTCCCAGACACCA
AATGCCTCATCCCCAGGCAACCCCACTGCTCTGGCCAATGGGACTGTGCAAGCACCCAAGCAGAAGGGAGACTGAGTGCCTCAGCCTCTC
ACCCCCTCCTCCTCAGGGCAGCGCTAGGGGCCTCCCCTATGCCTCAGCCCCATCTCTGCTCCTGTTTGAATTTTGTTATTGTTGTTTGGT
TGTTGTTTTTTTAAGTTGATTTTAATTTTTTGTTTGGTTGATTTTTTTGTAAAAAACTATTTTATATATAAATATAAATCTATATCTATA

>79210_79210_1_SARS-LPCAT4_SARS_chr1_109778053_ENST00000234677_LPCAT4_chr15_34657902_ENST00000314891_length(amino acids)=818AA_BP=332
MSVGPGGKKMVLDLDLFRVDKGGDPALIRETQEKRFKDPGLVDQLVKADSEWRRCRFRADNLNKLKNLCSKTIGEKMKKKEPVGDDESVP
ENVLSFDDLTADALANLKVSQIKKVRLLIDEAILKCDAERIKLEAERFENLREIGNLLHPSVPISNDEDVDNKVERIWGDCTVRKKYSHV
DLVVMVDGFEGEKGAVVAGSRGYFLKGVLVFLEQALIQYALRTLGSRGYIPIYTPFFMRKEVMQEVAQLSQFDEELYKVIGKGSEKSDDN
SYDEKYLIATSEQPIAALHRDEWLRPEDLPIKYAGLSTCFRQEVGSHGRDTRGIFRVHQFEKFCLLGALLAPIRVLLAFIVLFLLWPFAW
LQVAGLSEEQLQEPITGWRKTVCHNGVLGLSRLLFFLLGFLRIRVRGQRASRLQAPVLVAAPHSTFFDPIVLLPCDLPKVVSRAENLSVP
VIGALLRFNQAILVSRHDPASRRRVVEEVRRRATSGGKWPQVLFFPEGTCSNKKALLKFKPGAFIAGVPVQPVLIRYPNSLDTTSWAWRG
PGVLKVLWLTASQPCSIVDVEFLPVYHPSPEESRDPTLYANNVQRVMAQALGIPATECEFVGSLPVIVVGRLKVALEPQLWELGKVLRKA
GLSAGYVDAGAEPGRSRMISQEEFARQLQLSDPQTVAGAFGYFQQDTKGLVDFRDVALALAALDGGRSLEELTRLAFELFAEEQAEGPNR
LLYKDGFSTILHLLLGSPHPAATALHAELCQAGSSQGLSLCQFQNFSLHDPLYGKLFSTYLRPPHTSRGTSQTPNASSPGNPTALANGTV

--------------------------------------------------------------
>79210_79210_2_SARS-LPCAT4_SARS_chr1_109778053_ENST00000369923_LPCAT4_chr15_34657902_ENST00000314891_length(transcript)=2663nt_BP=980nt
GAGGAAAGAAGATGGTGCTGGATCTGGATTTGTTTCGGGTGGATAAAGGAGGGGACCCAGCCCTCATCCGAGAGACGCAGGAGAAGCGCT
TCAAGGACCCGGGACTAGTGGACCAGCTGGTGAAGGCAGACAGCGAGTGGCGACGATGTAGATTTCGGGCAGACAACTTGAACAAGCTGA
AGAACCTATGCAGCAAGACAATCGGAGAGAAAATGAAGAAAAAAGAGCCAGTGGGAGATGATGAGTCTGTCCCAGAGAATGTGCTGAGTT
TCGATGACCTTACTGCAGACGCTTTAGCTAACCTGAAAGTCTCACAAATCAAAAAAGTCCGACTCCTCATTGATGAAGCCATCCTGAAGT
GTGACGCGGAGCGGATAAAGTTGGAAGCAGAGCGGTTTGAGAACCTCCGAGAGATTGGGAACCTTCTGCACCCTTCTGTACCCATCAGTA
ACGATGAGGATGTGGACAACAAAGTAGAGAGGATTTGGGGTGATTGTACAGTCAGGAAGAAGTACTCTCATGTGGACCTGGTGGTGATGG
TAGATGGCTTTGAAGGCGAAAAGGGGGCCGTGGTGGCTGGGAGTCGAGGGTACTTCTTGAAGGGGGTCCTGGTGTTCCTGGAACAGGCTC
TCATCCAGTATGCCCTTCGCACCTTGGGAAGTCGGGGCTACATTCCCATTTATACCCCCTTTTTCATGAGGAAGGAGGTCATGCAGGAGG
TGGCACAGCTCAGCCAGTTTGATGAAGAACTTTATAAGGTGATTGGCAAAGGCAGTGAAAAGTCTGATGACAACTCCTATGATGAGAAGT
ACCTGATTGCCACCTCAGAGCAGCCCATTGCTGCCCTGCACCGGGATGAGTGGCTCCGGCCGGAGGACCTGCCCATCAAGTATGCTGGCC
TGTCTACCTGCTTCCGTCAGGAGGTGGGCTCCCATGGCCGTGACACCCGTGGCATCTTCCGAGTCCATCAGTTTGAGAAGTTCTGCCTCC
TGGGGGCATTGCTGGCCCCCATCCGAGTGCTTCTGGCCTTTATCGTCCTCTTTCTCCTCTGGCCCTTTGCCTGGCTTCAAGTGGCCGGTC
TTAGTGAGGAGCAGCTTCAGGAGCCAATTACAGGATGGAGGAAGACTGTGTGCCACAACGGGGTGCTAGGCCTGAGCCGCCTGCTGTTTT
TCCTGCTGGGCTTCCTCCGGATTCGCGTTCGTGGCCAGCGAGCCTCTCGCCTTCAAGCCCCTGTCCTTGTTGCTGCCCCACACTCCACTT
TCTTTGACCCCATTGTTCTGCTGCCCTGTGACCTGCCCAAAGTTGTGTCCCGAGCTGAGAACCTTTCCGTTCCTGTCATTGGAGCCCTTC
TTCGATTCAACCAAGCCATCCTGGTATCCCGGCATGACCCGGCTTCTCGACGCAGAGTGGTGGAGGAGGTCCGAAGGCGGGCCACCTCAG
GAGGCAAGTGGCCGCAGGTGCTATTCTTTCCTGAGGGCACCTGTTCCAACAAGAAGGCTTTGCTTAAGTTCAAACCAGGAGCCTTCATCG
CAGGGGTGCCTGTGCAGCCTGTCCTCATCCGCTACCCCAACAGTCTGGACACCACCAGCTGGGCATGGAGGGGTCCTGGAGTACTCAAAG
TCCTCTGGCTCACAGCCTCTCAGCCCTGCAGCATTGTGGATGTGGAGTTCCTTCCTGTGTATCACCCCAGCCCTGAGGAGAGCAGGGACC
CCACCCTCTATGCCAACAATGTTCAGAGGGTCATGGCACAGGCTCTGGGCATTCCAGCCACCGAATGTGAGTTTGTAGGGAGCTTACCTG
TGATTGTGGTGGGCCGGCTGAAGGTGGCGTTGGAACCACAGCTCTGGGAACTGGGAAAAGTGCTTCGGAAGGCTGGGCTGTCCGCTGGCT
ATGTGGACGCTGGGGCAGAGCCAGGCCGGAGTCGAATGATCAGCCAGGAAGAGTTTGCCAGGCAGCTACAGCTCTCTGATCCTCAGACGG
TGGCTGGTGCCTTTGGCTACTTCCAGCAGGATACCAAGGGTTTGGTGGACTTCCGAGATGTGGCCCTTGCACTAGCAGCTCTGGATGGGG
GCAGGAGCCTGGAAGAGCTAACTCGTCTGGCCTTTGAGCTCTTTGCTGAAGAGCAAGCAGAGGGTCCCAACCGCCTGCTGTACAAAGACG
GCTTCAGCACCATCCTGCACCTGCTGCTGGGTTCACCCCACCCTGCTGCCACAGCTTTGCATGCTGAGCTGTGCCAGGCAGGATCCAGCC
AAGGCCTCTCCCTCTGTCAGTTCCAGAACTTCTCCCTCCATGACCCACTCTATGGGAAACTCTTCAGCACCTACCTGCGCCCCCCACACA
CCTCTCGAGGCACCTCCCAGACACCAAATGCCTCATCCCCAGGCAACCCCACTGCTCTGGCCAATGGGACTGTGCAAGCACCCAAGCAGA
AGGGAGACTGAGTGCCTCAGCCTCTCACCCCCTCCTCCTCAGGGCAGCGCTAGGGGCCTCCCCTATGCCTCAGCCCCATCTCTGCTCCTG
TTTGAATTTTGTTATTGTTGTTTGGTTGTTGTTTTTTTAAGTTGATTTTAATTTTTTGTTTGGTTGATTTTTTTGTAAAAAACTATTTTA

>79210_79210_2_SARS-LPCAT4_SARS_chr1_109778053_ENST00000369923_LPCAT4_chr15_34657902_ENST00000314891_length(amino acids)=809AA_BP=323
MVLDLDLFRVDKGGDPALIRETQEKRFKDPGLVDQLVKADSEWRRCRFRADNLNKLKNLCSKTIGEKMKKKEPVGDDESVPENVLSFDDL
TADALANLKVSQIKKVRLLIDEAILKCDAERIKLEAERFENLREIGNLLHPSVPISNDEDVDNKVERIWGDCTVRKKYSHVDLVVMVDGF
EGEKGAVVAGSRGYFLKGVLVFLEQALIQYALRTLGSRGYIPIYTPFFMRKEVMQEVAQLSQFDEELYKVIGKGSEKSDDNSYDEKYLIA
TSEQPIAALHRDEWLRPEDLPIKYAGLSTCFRQEVGSHGRDTRGIFRVHQFEKFCLLGALLAPIRVLLAFIVLFLLWPFAWLQVAGLSEE
QLQEPITGWRKTVCHNGVLGLSRLLFFLLGFLRIRVRGQRASRLQAPVLVAAPHSTFFDPIVLLPCDLPKVVSRAENLSVPVIGALLRFN
QAILVSRHDPASRRRVVEEVRRRATSGGKWPQVLFFPEGTCSNKKALLKFKPGAFIAGVPVQPVLIRYPNSLDTTSWAWRGPGVLKVLWL
TASQPCSIVDVEFLPVYHPSPEESRDPTLYANNVQRVMAQALGIPATECEFVGSLPVIVVGRLKVALEPQLWELGKVLRKAGLSAGYVDA
GAEPGRSRMISQEEFARQLQLSDPQTVAGAFGYFQQDTKGLVDFRDVALALAALDGGRSLEELTRLAFELFAEEQAEGPNRLLYKDGFST

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Fusion Gene PPI Analysis for SARS-LPCAT4


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
HgeneSARSchr1:109778053chr15:34657902ENST00000234677+7119_61323.0515.0tRNA


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for SARS-LPCAT4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for SARS-LPCAT4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource