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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:SBNO2-SPOCK1 (FusionGDB2 ID:79371)

Fusion Gene Summary for SBNO2-SPOCK1

Fusion gene summary

Fusion gene information	Fusion gene name: SBNO2-SPOCK1
	Fusion gene ID: 79371
		Hgene	Tgene
	Gene symbol	SBNO2	SPOCK1
	Gene ID	22904	6695
	Gene name	strawberry notch homolog 2	SPARC (osteonectin), cwcv and kazal like domains proteoglycan 1
	Synonyms	KIAA0963\|SNO\|STNO	SPOCK\|TESTICAN\|TIC1
	Cytomap	19p13.3	5q31.2
	Type of gene	protein-coding	protein-coding
	Description	protein strawberry notch homolog 2	testican-1SPARC/osteonectin, cwcv and kazal like domains proteoglycan 1sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
	Modification date	20200313	20200313
	UniProtAcc	.	.
	Ensembl transtripts involved in fusion gene	ENST00000361757, ENST00000587024, ENST00000438103,	ENST00000509978, ENST00000282223, ENST00000394945,
Fusion gene scores	* DoF score	29 X 15 X 16=6960	7 X 7 X 3=147
	# samples	38	7
	** MAII score	log2(38/6960*10)=-4.19501598240514 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(7/147*10)=-1.0703893278914 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: SBNO2 [Title/Abstract] AND SPOCK1 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	SBNO2(1147308)-SPOCK1(136476383), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	SBNO2	GO:0071354	cellular response to interleukin-6	25903009
Tgene	SPOCK1	GO:0010812	negative regulation of cell-substrate adhesion	12853036
Tgene	SPOCK1	GO:0010951	negative regulation of endopeptidase activity	14511383
Tgene	SPOCK1	GO:0010977	negative regulation of neuron projection development	12853036

Fusion gene breakpoints across SBNO2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across SPOCK1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	UCEC	TCGA-A5-A0G5-01A	SBNO2	chr19	1147308	-	SPOCK1	chr5	136476383	-

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Fusion Gene ORF analysis for SBNO2-SPOCK1

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000361757	ENST00000509978	SBNO2	chr19	1147308	-	SPOCK1	chr5	136476383	-
5CDS-intron	ENST00000587024	ENST00000509978	SBNO2	chr19	1147308	-	SPOCK1	chr5	136476383	-
In-frame	ENST00000361757	ENST00000282223	SBNO2	chr19	1147308	-	SPOCK1	chr5	136476383	-
In-frame	ENST00000361757	ENST00000394945	SBNO2	chr19	1147308	-	SPOCK1	chr5	136476383	-
In-frame	ENST00000587024	ENST00000282223	SBNO2	chr19	1147308	-	SPOCK1	chr5	136476383	-
In-frame	ENST00000587024	ENST00000394945	SBNO2	chr19	1147308	-	SPOCK1	chr5	136476383	-
intron-3CDS	ENST00000438103	ENST00000282223	SBNO2	chr19	1147308	-	SPOCK1	chr5	136476383	-
intron-3CDS	ENST00000438103	ENST00000394945	SBNO2	chr19	1147308	-	SPOCK1	chr5	136476383	-
intron-intron	ENST00000438103	ENST00000509978	SBNO2	chr19	1147308	-	SPOCK1	chr5	136476383	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000361757	SBNO2	chr19	1147308	-	ENST00000394945	SPOCK1	chr5	136476383	-	4961	517	345	1604	419
ENST00000361757	SBNO2	chr19	1147308	-	ENST00000282223	SPOCK1	chr5	136476383	-	1646	517	345	1604	419
ENST00000587024	SBNO2	chr19	1147308	-	ENST00000394945	SPOCK1	chr5	136476383	-	4934	490	318	1577	419
ENST00000587024	SBNO2	chr19	1147308	-	ENST00000282223	SPOCK1	chr5	136476383	-	1619	490	318	1577	419

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000361757	ENST00000394945	SBNO2	chr19	1147308	-	SPOCK1	chr5	136476383	-	0.000557769	0.99944216
ENST00000361757	ENST00000282223	SBNO2	chr19	1147308	-	SPOCK1	chr5	136476383	-	0.007486237	0.9925137
ENST00000587024	ENST00000394945	SBNO2	chr19	1147308	-	SPOCK1	chr5	136476383	-	0.000543093	0.99945694
ENST00000587024	ENST00000282223	SBNO2	chr19	1147308	-	SPOCK1	chr5	136476383	-	0.006562856	0.9934371

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Fusion Genomic Features for SBNO2-SPOCK1

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for SBNO2-SPOCK1

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:1147308/chr5:136476383)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

SPOCK1

chr19:1147308

chr5:136476383

ENST00000282223

130_182

440.0

Domain

Kazal-like

Tgene

SPOCK1

chr19:1147308

chr5:136476383

ENST00000282223

310_376

440.0

Domain

Thyroglobulin type-1

Tgene

SPOCK1

chr19:1147308

chr5:136476383

ENST00000394945

130_182

440.0

Domain

Kazal-like

Tgene

SPOCK1

chr19:1147308

chr5:136476383

ENST00000394945

310_376

440.0

Domain

Thyroglobulin type-1

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

SBNO2

chr19:1147308

chr5:136476383

ENST00000361757

1234_1294

1367.0

Compositional bias

Note=Pro-rich

Hgene

SBNO2

chr19:1147308

chr5:136476383

ENST00000361757

183_195

1367.0

Compositional bias

Note=Poly-Glu

Hgene

SBNO2

chr19:1147308

chr5:136476383

ENST00000438103

1234_1294

1310.0

Compositional bias

Note=Pro-rich

Hgene

SBNO2

chr19:1147308

chr5:136476383

ENST00000438103

183_195

1310.0

Compositional bias

Note=Poly-Glu

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Fusion Gene Sequence for SBNO2-SPOCK1

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>79371_79371_1_SBNO2-SPOCK1_SBNO2_chr19_1147308_ENST00000361757_SPOCK1_chr5_136476383_ENST00000282223_length(transcript)=1646nt_BP=517nt
GTGCGCGGGGCCCCCAAGATGGCGCCCGAAACCCGGAAGTGAGCGGCGGCAGCTGCGAGGCTCGGAGAAACAGGCGCCGCGGGCTCCGCG
CCCGGCCGGACCCGGGCCCGAGATCATGATGCTGCCGCCACCGCCGCCACCACGGAGCGAGAAGCCCAGATAGACGCCCCGGCGGCCCCG
GGTCCTGGAGTCCCGCCGCCTGCTGCCCGGCCGAGGACCCCACCCCGCCTGCCGCCCGATGCTTGCAGTGGGGCCCGCCATGGACAGGGA
TTACCCGCAGCATGAACCCCCGCCGGCGGGCAGCCTCCTGTACAGCCCGCCGCCCCTGCAGAGCGCCATGCTGCACTGCCCCTACTGGAA
CACCTTCTCGCTGCCGCCATACCCTGCCTTCTCCAGCGACAGCCGCCCGTTCATGAGCTCCGCCTCCTTCCTCGGCAGCCAGCCCTGCCC
AGACACCAGCTATGCCCCCGTGGCCACCGCCTCCAGCTTGCCACCAAAGACCTGCGACTTTGCTCAGCCCTGGACCCATCCAAGGACCCC
TGCCTGAAGGTAAAATGCAGCCCTCACAAAGTGTGTGTGACCCAGGACTACCAGACCGCCCTGTGTGTCAGCCGCAAGCACCTGCTCCCC
AGGCAAAAGAAGGGGAACGTGGCCCAGAAACACTGGGTTGGACCTTCGAATTTGGTCAAGTGCAAGCCCTGTCCCGTGGCACAGTCAGCC
ATGGTCTGCGGCTCAGATGGCCACTCCTACACATCCAAGTGCAAATTGGAGTTCCATGCTTGTTCTACTGGCAAAAGCCTCGCCACCCTC
TGTGATGGGCCCTGTCCCTGTCTCCCAGAGCCTGAGCCACCAAAGCACAAGGCAGAAAGGAGTGCCTGCACAGACAAGGAGTTGCGGAAC
CTTGCCTCCCGGCTGAAGGATTGGTTTGGAGCTCTCCACGAGGATGCGAACAGAGTCATCAAGCCCACCAGCTCCAACACAGCCCAAGGC
AGGTTTGACACTAGCATCCTGCCCATCTGCAAGGACTCCCTGGGCTGGATGTTCAACAAGTTGGACATGAACTATGACCTCCTGCTTGAC
CCTTCAGAGATCAATGCCATCTACCTGGATAAGTACGAGCCCTGTATCAAGCCTCTTTTCAACTCGTGTGACTCCTTCAAGGATGGCAAG
CTTTCTAACAATGAGTGGTGCTACTGCTTCCAGAAGCCTGGAGGTCTCCCTTGCCAGAATGAAATGAACAGAATTCAGAAGCTGAGTAAG
GGGAAAAGCCTGTTGGGGGCCTTCATACCTCGGTGTAATGAGGAGGGCTATTACAAAGCCACACAGTGCCACGGCAGCACGGGGCAGTGC
TGGTGTGTGGACAAATATGGGAATGAGTTGGCTGGCTCCAGGAAACAGGGTGCTGTGAGCTGTGAAGAGGAGCAGGAAACCTCAGGGGAT
TTTGGCAGTGGTGGGTCCGTGGTCCTGCTGGATGACCTAGAATATGAACGGGAGCTGGGACCAAAGGACAAAGAGGGGAAGCTGAGGGTG
CACACCCGAGCCGTGACAGAGGATGATGAGGATGAGGATGATGACAAAGAGGATGAGGTCGGGTACATATGGTAGTGCCCACAAGAAAGA

>79371_79371_1_SBNO2-SPOCK1_SBNO2_chr19_1147308_ENST00000361757_SPOCK1_chr5_136476383_ENST00000282223_length(amino acids)=419AA_BP=56
MPLLEHLLAAAIPCLLQRQPPVHELRLLPRQPALPRHQLCPRGHRLQLATKDLRLCSALDPSKDPCLKVKCSPHKVCVTQDYQTALCVSR
KHLLPRQKKGNVAQKHWVGPSNLVKCKPCPVAQSAMVCGSDGHSYTSKCKLEFHACSTGKSLATLCDGPCPCLPEPEPPKHKAERSACTD
KELRNLASRLKDWFGALHEDANRVIKPTSSNTAQGRFDTSILPICKDSLGWMFNKLDMNYDLLLDPSEINAIYLDKYEPCIKPLFNSCDS
FKDGKLSNNEWCYCFQKPGGLPCQNEMNRIQKLSKGKSLLGAFIPRCNEEGYYKATQCHGSTGQCWCVDKYGNELAGSRKQGAVSCEEEQ

--------------------------------------------------------------
>79371_79371_2_SBNO2-SPOCK1_SBNO2_chr19_1147308_ENST00000361757_SPOCK1_chr5_136476383_ENST00000394945_length(transcript)=4961nt_BP=517nt
GTGCGCGGGGCCCCCAAGATGGCGCCCGAAACCCGGAAGTGAGCGGCGGCAGCTGCGAGGCTCGGAGAAACAGGCGCCGCGGGCTCCGCG
CCCGGCCGGACCCGGGCCCGAGATCATGATGCTGCCGCCACCGCCGCCACCACGGAGCGAGAAGCCCAGATAGACGCCCCGGCGGCCCCG
GGTCCTGGAGTCCCGCCGCCTGCTGCCCGGCCGAGGACCCCACCCCGCCTGCCGCCCGATGCTTGCAGTGGGGCCCGCCATGGACAGGGA
TTACCCGCAGCATGAACCCCCGCCGGCGGGCAGCCTCCTGTACAGCCCGCCGCCCCTGCAGAGCGCCATGCTGCACTGCCCCTACTGGAA
CACCTTCTCGCTGCCGCCATACCCTGCCTTCTCCAGCGACAGCCGCCCGTTCATGAGCTCCGCCTCCTTCCTCGGCAGCCAGCCCTGCCC
AGACACCAGCTATGCCCCCGTGGCCACCGCCTCCAGCTTGCCACCAAAGACCTGCGACTTTGCTCAGCCCTGGACCCATCCAAGGACCCC
TGCCTGAAGGTAAAATGCAGCCCTCACAAAGTGTGTGTGACCCAGGACTACCAGACCGCCCTGTGTGTCAGCCGCAAGCACCTGCTCCCC
AGGCAAAAGAAGGGGAACGTGGCCCAGAAACACTGGGTTGGACCTTCGAATTTGGTCAAGTGCAAGCCCTGTCCCGTGGCACAGTCAGCC
ATGGTCTGCGGCTCAGATGGCCACTCCTACACATCCAAGTGCAAATTGGAGTTCCATGCTTGTTCTACTGGCAAAAGCCTCGCCACCCTC
TGTGATGGGCCCTGTCCCTGTCTCCCAGAGCCTGAGCCACCAAAGCACAAGGCAGAAAGGAGTGCCTGCACAGACAAGGAGTTGCGGAAC
CTTGCCTCCCGGCTGAAGGATTGGTTTGGAGCTCTCCACGAGGATGCGAACAGAGTCATCAAGCCCACCAGCTCCAACACAGCCCAAGGC
AGGTTTGACACTAGCATCCTGCCCATCTGCAAGGACTCCCTGGGCTGGATGTTCAACAAGTTGGACATGAACTATGACCTCCTGCTTGAC
CCTTCAGAGATCAATGCCATCTACCTGGATAAGTACGAGCCCTGTATCAAGCCTCTTTTCAACTCGTGTGACTCCTTCAAGGATGGCAAG
CTTTCTAACAATGAGTGGTGCTACTGCTTCCAGAAGCCTGGAGGTCTCCCTTGCCAGAATGAAATGAACAGAATTCAGAAGCTGAGTAAG
GGGAAAAGCCTGTTGGGGGCCTTCATACCTCGGTGTAATGAGGAGGGCTATTACAAAGCCACACAGTGCCACGGCAGCACGGGGCAGTGC
TGGTGTGTGGACAAATATGGGAATGAGTTGGCTGGCTCCAGGAAACAGGGTGCTGTGAGCTGTGAAGAGGAGCAGGAAACCTCAGGGGAT
TTTGGCAGTGGTGGGTCCGTGGTCCTGCTGGATGACCTAGAATATGAACGGGAGCTGGGACCAAAGGACAAAGAGGGGAAGCTGAGGGTG
CACACCCGAGCCGTGACAGAGGATGATGAGGATGAGGATGATGACAAAGAGGATGAGGTCGGGTACATATGGTAGTGCCCACAAGAAAGA
GGACACAAGTTTTGCACAAAATTGCAAGTCACTTCCTATTCCTGCATTTGTATCTAAGACTCCAAGGCACCAAGGTCTCTTCTCCATTGT
TGCTCTCTATACCCGACCTAAGGTTTGGAAGACAACTGCTTGTTCCCAGAGGATTCTGATTTTGCATATGTTTGTATGGGAGAAAGGGTG
TTGTGTTTTTTTTTTGTTGTTGTTTATTTTTTGGATAGGGAAGTCATTGGCTTAATTAGAGCCTCCTTCCTTTCTGTGAGATTTTTCCAA
CAAGCATGTGATTTACGTGGAATTCTGACAGTGCAGGGAGCCCCAACCCTCTTAAATGTCAAAGACCCTTTTTGATTACCCACACTGGTG
GTTATTACAGCATGGTTCCCAGCCTTACAGTGTCTAAGTGCTTCTCTTGTGTCCTGTAGATGTTGTGAAAAAGAAAAAAACAAAAAATAC
ACCACACTGTACTTTTTCCCCCTGCCCCCGTTACTGCCGGTGATTATTATTAAAAATTAGTTTTTTTCACATCATTATATCTGGCTTCCT
ATAAACAACAGCCTTAATTCAGTCAAGACTCCCTTTGGGGAATTCATTTTATTAAAAATTGGTGTCTGGATACTTCCCTGTACATGCATA
AATATGCATGCATGTACAGAAAGACTGTATGTGTGTGCCTTGCACACACACCCATACCTCTCAGAAAAAGTGTTTGGGTATCTTAAAAAC
TCGAAAAACAATGATAAATTTCTCAGCTTGTCCAGACCTGGAACAAAATTTCTGGAATAAGAAATTTGTATTAAAGTCCTTTTTTGCACT
AACAGTTGGCTCTTGTAGCCTGCAGGCTGAGGAAGTCTCTTCTCTGTGCATCAGCAGAGTTACTGAAAGCCTCTGATTGAGAAAAAACCT
CCGTCTGCCTAAATCACTTTTCTCGCAGAAGCCATGCGACTCCCACACGACACGGGCAGCTTCACAAGCCATCTCTTTCATTTCTGCTTG
AAGCCCCTTGGCTGCAGCAATCCTGTCTGCCATAGGTTTCTTCCTTCCTTACCTACTCAAGGGCTTTTTCTAAGGCATGCACACATATCT
CCTGTTCTCTGAGAGTACCATGGTGTTCCTTAAAAGAAGAAAATTTCTAATTCTGAACTCAATGTTTTGCTTTTACTCCCTTTCTACTGA
CAAATCATGATAAGGGCACAAAAGCTGTACAGATTTTTTTTTTTAACCACTCAATCCCAAATGGAGGCCTACAAAGAACATCGTAATAAC
ACATGGAAGCAAACCCTGGGTTTTTAAGAGCAAATTCTGTCCCCCCCTCACTCCCCCAAGTGACAAGATACTAATGAAGAAAGTTCTTCA
CCATAGTGTTTGTTTTAACTAAACTCATTGGAGTCTAGTTCCAAATTTGGTAGGGTCATCATCTCTACATTCCTTAGGATTTCTCTCCCT
ATCAAGCTGGCCCAGATACAAGTACCAAACAGTAGTCTCTGAAGTTCCCCCATTTCCTTCAGTACCAGTCTATAAGCTACTGTCCGCCAC
TGATTTTCATTTATCAGGGTGTCCTAATCAGAATCAGCCACCCAAGCAAGCCTCTCTGGCCCACATATCTATCTCTTGCCTTCCCCCATG
AACTTCAGCCTGTCCACACAAAAGCCACATAAACTCAAGCAAGAAATATGTTCAGCCAAAACATGATTATAGTGGCAGCTGACCAATCCC
CCATCCCAAATTGACCATTTAGATGTACCAACTCACCTTAAATTAGCATGTTCCAATCCAGTCGGCATTGCCTGAATACAGTAGCATCAT
ACCTATAGTTGGTCTTAGATAAGAAATGAACTACTTGATATAGCAAAGTCCTTTGGCTTCGTAAATAACCCTGAGGTTTTGTACTTACTT
TCCCCATAGGAAGACAGACCATAGGCAAACTCTGTTTTGGGATCTCAACTCCATCACCTTTGTTTCAATATTTTTTTTCTCTCTTGAACA
AAACTGAGATAATTTAGAAAACAGGTGCTTAATTGCAATAAAATTACTATGAAGTATATTAAAAATCACGACATTGTAAAATCTCACTTT
AGATCATCAAAGAAAACCATTGTTACTATCTCCTTTGAGCTTAGGAAAATGTACAAGAGAACAAATTAAAATTGAAAAATTGATTTCACT
TAGAAAAACTTCTAGGAACAGGGTGAACCACTGATTTTAATTTGCCTAATTATCTTATGACAAGTATCAAATTAAGATGACACTTAAAGA
TCCTTAGCATTAACTTAATGATGGAGAAGAGTGCTCAATAGACAGTTCCCAGTAAGGTAATGAGATGCCATTTTCAGAGACATTCTAAGA
AGATATTTTGATTCATTAAAACATTAAATAAAAAGCCCTCCTCAGATTGGAACCCCCAAATCGATGGAGCCACATTAATAATACTTTTCA
TGCCTCACTTTGACATGACAGCATTCGATTTTTTTAAAGATCTTTAATACTTTCCATGAGTACTAAAGATTGTAATGAGTTACCTTATCC
TTAGAAGTAGAATGTTTGCTTTCTTCTTCTTGGAAATAGTCCTCCAAAAAGTCCACTTGTACCAGTGACAAGAAGTCACTTGTATAGTGA
CCAAGTACACATAAAATACTGATTATAAAAATATTGTAATAAACCACTTCCTCATTTGATACAGGTATTAAGCTGAATCCTCACTAATTC
ACTTTTGAAAAGTTCTTAATGAACAGTTTTATTCTTATTCCATGAACAGCTCTTTTAATACAATTTCCTTGGTATCCAACTTAAATCCCA
GAATTTTGTTCCACCATGGTTAGTTATTTGCCATATGAATGTATTCTTGTTTCTACCAATATTCTAGGCATGAGAATACCTTAATACTGA
GTTGGAGATTTTGTATCTGTTTCTCCTCCTTTACGCCCATTTTCCTACCCACAGCAGCAAATGACAACGTGTCTGTCCAGGTCTGTCCCC
CTGCTCATCCCAGGATGCCACTCACATTTTTTTCTTCTTGTTACCTTGACCACGCTGTACAGTAACATCCAAGAGCCCATTCTACAGTGG
GTGGTTTTGGTCTTTTTATAACTTTTTCTCAAAGTCACTGATGTTTGTTCCTGTTAAATGTATAGCATTGTAATGAGAGCCCATCAAATC
CTGAGTGTCAGTTTGTTGTCCCTATTGTAGATGAAATAGTGATGTAGCAAAAACCTAGTAAATTCTGAATGCTTTTCCACGTAGACTTAT
CTGGAATGTGAACACAACTCTTTGGTTAATAGTAAATGCTTAACTGTAGTCCTGAGTAGGTGCATTTCTGTCTGTCTCAATAAATTTTAC

>79371_79371_2_SBNO2-SPOCK1_SBNO2_chr19_1147308_ENST00000361757_SPOCK1_chr5_136476383_ENST00000394945_length(amino acids)=419AA_BP=56
MPLLEHLLAAAIPCLLQRQPPVHELRLLPRQPALPRHQLCPRGHRLQLATKDLRLCSALDPSKDPCLKVKCSPHKVCVTQDYQTALCVSR
KHLLPRQKKGNVAQKHWVGPSNLVKCKPCPVAQSAMVCGSDGHSYTSKCKLEFHACSTGKSLATLCDGPCPCLPEPEPPKHKAERSACTD
KELRNLASRLKDWFGALHEDANRVIKPTSSNTAQGRFDTSILPICKDSLGWMFNKLDMNYDLLLDPSEINAIYLDKYEPCIKPLFNSCDS
FKDGKLSNNEWCYCFQKPGGLPCQNEMNRIQKLSKGKSLLGAFIPRCNEEGYYKATQCHGSTGQCWCVDKYGNELAGSRKQGAVSCEEEQ

--------------------------------------------------------------
>79371_79371_3_SBNO2-SPOCK1_SBNO2_chr19_1147308_ENST00000587024_SPOCK1_chr5_136476383_ENST00000282223_length(transcript)=1619nt_BP=490nt
GAAACCCGGAAGTGAGCGGCGGCAGCTGCGAGGCTCGGAGAAACAGGCGCCGCGGGCTCCGCGCCCGGCCGGACCCGGGCCCGAGATCAT
GATGCTGCCGCCACCGCCGCCACCACGGAGCGAGAAGCCCAGATAGACGCCCCGGCGGCCCCGGGTCCTGGAGTCCCGCCGCCTGCTGCC
CGGCCGAGGACCCCACCCCGCCTGCCGCCCGATGCTTGCAGTGGGGCCCGCCATGGACAGGGATTACCCGCAGCATGAACCCCCGCCGGC
GGGCAGCCTCCTGTACAGCCCGCCGCCCCTGCAGAGCGCCATGCTGCACTGCCCCTACTGGAACACCTTCTCGCTGCCGCCATACCCTGC
CTTCTCCAGCGACAGCCGCCCGTTCATGAGCTCCGCCTCCTTCCTCGGCAGCCAGCCCTGCCCAGACACCAGCTATGCCCCCGTGGCCAC
CGCCTCCAGCTTGCCACCAAAGACCTGCGACTTTGCTCAGCCCTGGACCCATCCAAGGACCCCTGCCTGAAGGTAAAATGCAGCCCTCAC
AAAGTGTGTGTGACCCAGGACTACCAGACCGCCCTGTGTGTCAGCCGCAAGCACCTGCTCCCCAGGCAAAAGAAGGGGAACGTGGCCCAG
AAACACTGGGTTGGACCTTCGAATTTGGTCAAGTGCAAGCCCTGTCCCGTGGCACAGTCAGCCATGGTCTGCGGCTCAGATGGCCACTCC
TACACATCCAAGTGCAAATTGGAGTTCCATGCTTGTTCTACTGGCAAAAGCCTCGCCACCCTCTGTGATGGGCCCTGTCCCTGTCTCCCA
GAGCCTGAGCCACCAAAGCACAAGGCAGAAAGGAGTGCCTGCACAGACAAGGAGTTGCGGAACCTTGCCTCCCGGCTGAAGGATTGGTTT
GGAGCTCTCCACGAGGATGCGAACAGAGTCATCAAGCCCACCAGCTCCAACACAGCCCAAGGCAGGTTTGACACTAGCATCCTGCCCATC
TGCAAGGACTCCCTGGGCTGGATGTTCAACAAGTTGGACATGAACTATGACCTCCTGCTTGACCCTTCAGAGATCAATGCCATCTACCTG
GATAAGTACGAGCCCTGTATCAAGCCTCTTTTCAACTCGTGTGACTCCTTCAAGGATGGCAAGCTTTCTAACAATGAGTGGTGCTACTGC
TTCCAGAAGCCTGGAGGTCTCCCTTGCCAGAATGAAATGAACAGAATTCAGAAGCTGAGTAAGGGGAAAAGCCTGTTGGGGGCCTTCATA
CCTCGGTGTAATGAGGAGGGCTATTACAAAGCCACACAGTGCCACGGCAGCACGGGGCAGTGCTGGTGTGTGGACAAATATGGGAATGAG
TTGGCTGGCTCCAGGAAACAGGGTGCTGTGAGCTGTGAAGAGGAGCAGGAAACCTCAGGGGATTTTGGCAGTGGTGGGTCCGTGGTCCTG
CTGGATGACCTAGAATATGAACGGGAGCTGGGACCAAAGGACAAAGAGGGGAAGCTGAGGGTGCACACCCGAGCCGTGACAGAGGATGAT

>79371_79371_3_SBNO2-SPOCK1_SBNO2_chr19_1147308_ENST00000587024_SPOCK1_chr5_136476383_ENST00000282223_length(amino acids)=419AA_BP=56
MPLLEHLLAAAIPCLLQRQPPVHELRLLPRQPALPRHQLCPRGHRLQLATKDLRLCSALDPSKDPCLKVKCSPHKVCVTQDYQTALCVSR
KHLLPRQKKGNVAQKHWVGPSNLVKCKPCPVAQSAMVCGSDGHSYTSKCKLEFHACSTGKSLATLCDGPCPCLPEPEPPKHKAERSACTD
KELRNLASRLKDWFGALHEDANRVIKPTSSNTAQGRFDTSILPICKDSLGWMFNKLDMNYDLLLDPSEINAIYLDKYEPCIKPLFNSCDS
FKDGKLSNNEWCYCFQKPGGLPCQNEMNRIQKLSKGKSLLGAFIPRCNEEGYYKATQCHGSTGQCWCVDKYGNELAGSRKQGAVSCEEEQ

--------------------------------------------------------------
>79371_79371_4_SBNO2-SPOCK1_SBNO2_chr19_1147308_ENST00000587024_SPOCK1_chr5_136476383_ENST00000394945_length(transcript)=4934nt_BP=490nt
GAAACCCGGAAGTGAGCGGCGGCAGCTGCGAGGCTCGGAGAAACAGGCGCCGCGGGCTCCGCGCCCGGCCGGACCCGGGCCCGAGATCAT
GATGCTGCCGCCACCGCCGCCACCACGGAGCGAGAAGCCCAGATAGACGCCCCGGCGGCCCCGGGTCCTGGAGTCCCGCCGCCTGCTGCC
CGGCCGAGGACCCCACCCCGCCTGCCGCCCGATGCTTGCAGTGGGGCCCGCCATGGACAGGGATTACCCGCAGCATGAACCCCCGCCGGC
GGGCAGCCTCCTGTACAGCCCGCCGCCCCTGCAGAGCGCCATGCTGCACTGCCCCTACTGGAACACCTTCTCGCTGCCGCCATACCCTGC
CTTCTCCAGCGACAGCCGCCCGTTCATGAGCTCCGCCTCCTTCCTCGGCAGCCAGCCCTGCCCAGACACCAGCTATGCCCCCGTGGCCAC
CGCCTCCAGCTTGCCACCAAAGACCTGCGACTTTGCTCAGCCCTGGACCCATCCAAGGACCCCTGCCTGAAGGTAAAATGCAGCCCTCAC
AAAGTGTGTGTGACCCAGGACTACCAGACCGCCCTGTGTGTCAGCCGCAAGCACCTGCTCCCCAGGCAAAAGAAGGGGAACGTGGCCCAG
AAACACTGGGTTGGACCTTCGAATTTGGTCAAGTGCAAGCCCTGTCCCGTGGCACAGTCAGCCATGGTCTGCGGCTCAGATGGCCACTCC
TACACATCCAAGTGCAAATTGGAGTTCCATGCTTGTTCTACTGGCAAAAGCCTCGCCACCCTCTGTGATGGGCCCTGTCCCTGTCTCCCA
GAGCCTGAGCCACCAAAGCACAAGGCAGAAAGGAGTGCCTGCACAGACAAGGAGTTGCGGAACCTTGCCTCCCGGCTGAAGGATTGGTTT
GGAGCTCTCCACGAGGATGCGAACAGAGTCATCAAGCCCACCAGCTCCAACACAGCCCAAGGCAGGTTTGACACTAGCATCCTGCCCATC
TGCAAGGACTCCCTGGGCTGGATGTTCAACAAGTTGGACATGAACTATGACCTCCTGCTTGACCCTTCAGAGATCAATGCCATCTACCTG
GATAAGTACGAGCCCTGTATCAAGCCTCTTTTCAACTCGTGTGACTCCTTCAAGGATGGCAAGCTTTCTAACAATGAGTGGTGCTACTGC
TTCCAGAAGCCTGGAGGTCTCCCTTGCCAGAATGAAATGAACAGAATTCAGAAGCTGAGTAAGGGGAAAAGCCTGTTGGGGGCCTTCATA
CCTCGGTGTAATGAGGAGGGCTATTACAAAGCCACACAGTGCCACGGCAGCACGGGGCAGTGCTGGTGTGTGGACAAATATGGGAATGAG
TTGGCTGGCTCCAGGAAACAGGGTGCTGTGAGCTGTGAAGAGGAGCAGGAAACCTCAGGGGATTTTGGCAGTGGTGGGTCCGTGGTCCTG
CTGGATGACCTAGAATATGAACGGGAGCTGGGACCAAAGGACAAAGAGGGGAAGCTGAGGGTGCACACCCGAGCCGTGACAGAGGATGAT
GAGGATGAGGATGATGACAAAGAGGATGAGGTCGGGTACATATGGTAGTGCCCACAAGAAAGAGGACACAAGTTTTGCACAAAATTGCAA
GTCACTTCCTATTCCTGCATTTGTATCTAAGACTCCAAGGCACCAAGGTCTCTTCTCCATTGTTGCTCTCTATACCCGACCTAAGGTTTG
GAAGACAACTGCTTGTTCCCAGAGGATTCTGATTTTGCATATGTTTGTATGGGAGAAAGGGTGTTGTGTTTTTTTTTTGTTGTTGTTTAT
TTTTTGGATAGGGAAGTCATTGGCTTAATTAGAGCCTCCTTCCTTTCTGTGAGATTTTTCCAACAAGCATGTGATTTACGTGGAATTCTG
ACAGTGCAGGGAGCCCCAACCCTCTTAAATGTCAAAGACCCTTTTTGATTACCCACACTGGTGGTTATTACAGCATGGTTCCCAGCCTTA
CAGTGTCTAAGTGCTTCTCTTGTGTCCTGTAGATGTTGTGAAAAAGAAAAAAACAAAAAATACACCACACTGTACTTTTTCCCCCTGCCC
CCGTTACTGCCGGTGATTATTATTAAAAATTAGTTTTTTTCACATCATTATATCTGGCTTCCTATAAACAACAGCCTTAATTCAGTCAAG
ACTCCCTTTGGGGAATTCATTTTATTAAAAATTGGTGTCTGGATACTTCCCTGTACATGCATAAATATGCATGCATGTACAGAAAGACTG
TATGTGTGTGCCTTGCACACACACCCATACCTCTCAGAAAAAGTGTTTGGGTATCTTAAAAACTCGAAAAACAATGATAAATTTCTCAGC
TTGTCCAGACCTGGAACAAAATTTCTGGAATAAGAAATTTGTATTAAAGTCCTTTTTTGCACTAACAGTTGGCTCTTGTAGCCTGCAGGC
TGAGGAAGTCTCTTCTCTGTGCATCAGCAGAGTTACTGAAAGCCTCTGATTGAGAAAAAACCTCCGTCTGCCTAAATCACTTTTCTCGCA
GAAGCCATGCGACTCCCACACGACACGGGCAGCTTCACAAGCCATCTCTTTCATTTCTGCTTGAAGCCCCTTGGCTGCAGCAATCCTGTC
TGCCATAGGTTTCTTCCTTCCTTACCTACTCAAGGGCTTTTTCTAAGGCATGCACACATATCTCCTGTTCTCTGAGAGTACCATGGTGTT
CCTTAAAAGAAGAAAATTTCTAATTCTGAACTCAATGTTTTGCTTTTACTCCCTTTCTACTGACAAATCATGATAAGGGCACAAAAGCTG
TACAGATTTTTTTTTTTAACCACTCAATCCCAAATGGAGGCCTACAAAGAACATCGTAATAACACATGGAAGCAAACCCTGGGTTTTTAA
GAGCAAATTCTGTCCCCCCCTCACTCCCCCAAGTGACAAGATACTAATGAAGAAAGTTCTTCACCATAGTGTTTGTTTTAACTAAACTCA
TTGGAGTCTAGTTCCAAATTTGGTAGGGTCATCATCTCTACATTCCTTAGGATTTCTCTCCCTATCAAGCTGGCCCAGATACAAGTACCA
AACAGTAGTCTCTGAAGTTCCCCCATTTCCTTCAGTACCAGTCTATAAGCTACTGTCCGCCACTGATTTTCATTTATCAGGGTGTCCTAA
TCAGAATCAGCCACCCAAGCAAGCCTCTCTGGCCCACATATCTATCTCTTGCCTTCCCCCATGAACTTCAGCCTGTCCACACAAAAGCCA
CATAAACTCAAGCAAGAAATATGTTCAGCCAAAACATGATTATAGTGGCAGCTGACCAATCCCCCATCCCAAATTGACCATTTAGATGTA
CCAACTCACCTTAAATTAGCATGTTCCAATCCAGTCGGCATTGCCTGAATACAGTAGCATCATACCTATAGTTGGTCTTAGATAAGAAAT
GAACTACTTGATATAGCAAAGTCCTTTGGCTTCGTAAATAACCCTGAGGTTTTGTACTTACTTTCCCCATAGGAAGACAGACCATAGGCA
AACTCTGTTTTGGGATCTCAACTCCATCACCTTTGTTTCAATATTTTTTTTCTCTCTTGAACAAAACTGAGATAATTTAGAAAACAGGTG
CTTAATTGCAATAAAATTACTATGAAGTATATTAAAAATCACGACATTGTAAAATCTCACTTTAGATCATCAAAGAAAACCATTGTTACT
ATCTCCTTTGAGCTTAGGAAAATGTACAAGAGAACAAATTAAAATTGAAAAATTGATTTCACTTAGAAAAACTTCTAGGAACAGGGTGAA
CCACTGATTTTAATTTGCCTAATTATCTTATGACAAGTATCAAATTAAGATGACACTTAAAGATCCTTAGCATTAACTTAATGATGGAGA
AGAGTGCTCAATAGACAGTTCCCAGTAAGGTAATGAGATGCCATTTTCAGAGACATTCTAAGAAGATATTTTGATTCATTAAAACATTAA
ATAAAAAGCCCTCCTCAGATTGGAACCCCCAAATCGATGGAGCCACATTAATAATACTTTTCATGCCTCACTTTGACATGACAGCATTCG
ATTTTTTTAAAGATCTTTAATACTTTCCATGAGTACTAAAGATTGTAATGAGTTACCTTATCCTTAGAAGTAGAATGTTTGCTTTCTTCT
TCTTGGAAATAGTCCTCCAAAAAGTCCACTTGTACCAGTGACAAGAAGTCACTTGTATAGTGACCAAGTACACATAAAATACTGATTATA
AAAATATTGTAATAAACCACTTCCTCATTTGATACAGGTATTAAGCTGAATCCTCACTAATTCACTTTTGAAAAGTTCTTAATGAACAGT
TTTATTCTTATTCCATGAACAGCTCTTTTAATACAATTTCCTTGGTATCCAACTTAAATCCCAGAATTTTGTTCCACCATGGTTAGTTAT
TTGCCATATGAATGTATTCTTGTTTCTACCAATATTCTAGGCATGAGAATACCTTAATACTGAGTTGGAGATTTTGTATCTGTTTCTCCT
CCTTTACGCCCATTTTCCTACCCACAGCAGCAAATGACAACGTGTCTGTCCAGGTCTGTCCCCCTGCTCATCCCAGGATGCCACTCACAT
TTTTTTCTTCTTGTTACCTTGACCACGCTGTACAGTAACATCCAAGAGCCCATTCTACAGTGGGTGGTTTTGGTCTTTTTATAACTTTTT
CTCAAAGTCACTGATGTTTGTTCCTGTTAAATGTATAGCATTGTAATGAGAGCCCATCAAATCCTGAGTGTCAGTTTGTTGTCCCTATTG
TAGATGAAATAGTGATGTAGCAAAAACCTAGTAAATTCTGAATGCTTTTCCACGTAGACTTATCTGGAATGTGAACACAACTCTTTGGTT

>79371_79371_4_SBNO2-SPOCK1_SBNO2_chr19_1147308_ENST00000587024_SPOCK1_chr5_136476383_ENST00000394945_length(amino acids)=419AA_BP=56
MPLLEHLLAAAIPCLLQRQPPVHELRLLPRQPALPRHQLCPRGHRLQLATKDLRLCSALDPSKDPCLKVKCSPHKVCVTQDYQTALCVSR
KHLLPRQKKGNVAQKHWVGPSNLVKCKPCPVAQSAMVCGSDGHSYTSKCKLEFHACSTGKSLATLCDGPCPCLPEPEPPKHKAERSACTD
KELRNLASRLKDWFGALHEDANRVIKPTSSNTAQGRFDTSILPICKDSLGWMFNKLDMNYDLLLDPSEINAIYLDKYEPCIKPLFNSCDS
FKDGKLSNNEWCYCFQKPGGLPCQNEMNRIQKLSKGKSLLGAFIPRCNEEGYYKATQCHGSTGQCWCVDKYGNELAGSRKQGAVSCEEEQ

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for SBNO2-SPOCK1

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for SBNO2-SPOCK1

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for SBNO2-SPOCK1

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source