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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ATP5B-RANBP2 (FusionGDB2 ID:7938)

Fusion Gene Summary for ATP5B-RANBP2

check button Fusion gene summary
Fusion gene informationFusion gene name: ATP5B-RANBP2
Fusion gene ID: 7938
HgeneTgene
Gene symbol

ATP5B

RANBP2

Gene ID

506

5903

Gene nameATP synthase F1 subunit betaRAN binding protein 2
SynonymsATP5B|ATPMB|ATPSB|HEL-S-271ADANE|ANE1|IIAE3|NUP358|TRP1|TRP2
Cytomap

12q13.3

2q13

Type of geneprotein-codingprotein-coding
DescriptionATP synthase subunit beta, mitochondrialATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptideepididymis secretory protein Li 271mitochondrial ATP synthase beta subunitmitochondrial ATP synthetase, beta subunitE3 SUMO-protein ligase RanBP2358 kDa nucleoporinE3 SUMO-protein transferase RanBP2P270acute necrotizing encephalopathy 1 (autosomal dominant)nuclear pore complex protein Nup358nucleoporin 358nucleoporin Nup358ran-binding protein 2transformation-r
Modification date2020032720200313
UniProtAcc.

RGPD8

Ensembl transtripts involved in fusion geneENST00000262030, ENST00000552919, 
ENST00000550162, 		ENST00000283195, 
Fusion gene scores* DoF score17 X 19 X 7=226114 X 14 X 3=588
# samples 2214
** MAII scorelog2(22/2261*10)=-3.36138556322687
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(14/588*10)=-2.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ATP5B [Title/Abstract] AND RANBP2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointATP5B(57032890)-RANBP2(109400052), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneATP5B

GO:0042776

mitochondrial ATP synthesis coupled proton transport

12110673

TgeneRANBP2

GO:0016925

protein sumoylation

17264123|22155184


check buttonFusion gene breakpoints across ATP5B (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across RANBP2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-BR-A4PD-01AATP5Bchr12

57032890

-RANBP2chr2

109400052

+


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Fusion Gene ORF analysis for ATP5B-RANBP2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000262030ENST00000283195ATP5Bchr12

57032890

-RANBP2chr2

109400052

+
In-frameENST00000552919ENST00000283195ATP5Bchr12

57032890

-RANBP2chr2

109400052

+
intron-3CDSENST00000550162ENST00000283195ATP5Bchr12

57032890

-RANBP2chr2

109400052

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000262030ATP5Bchr1257032890-ENST00000283195RANBP2chr2109400052+37561540511562503
ENST00000552919ATP5Bchr1257032890-ENST00000283195RANBP2chr2109400052+36821466101488492

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000262030ENST00000283195ATP5Bchr1257032890-RANBP2chr2109400052+0.0001273140.9998727
ENST00000552919ENST00000283195ATP5Bchr1257032890-RANBP2chr2109400052+0.0001182020.99988174

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Fusion Genomic Features for ATP5B-RANBP2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
ATP5Bchr1257032889-RANBP2chr2109400051+3.24E-091
ATP5Bchr1257032889-RANBP2chr2109400051+3.24E-091

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for ATP5B-RANBP2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:57032890/chr2:109400052)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.RANBP2

RGPD8

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.1765

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneATP5Bchr12:57032890chr2:109400052ENST00000262030-910207_214496530.0Nucleotide bindingATP
TgeneRANBP2chr12:57032890chr2:109400052ENST0000028319527293189_319031233225.0Repeat21
TgeneRANBP2chr12:57032890chr2:109400052ENST0000028319527293205_320631233225.0Repeat22

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneRANBP2chr12:57032890chr2:109400052ENST0000028319527291171_130731233225.0DomainRanBD1 1
TgeneRANBP2chr12:57032890chr2:109400052ENST0000028319527292012_214831233225.0DomainRanBD1 2
TgeneRANBP2chr12:57032890chr2:109400052ENST0000028319527292309_244531233225.0DomainRanBD1 3
TgeneRANBP2chr12:57032890chr2:109400052ENST0000028319527292911_304631233225.0DomainRanBD1 4
TgeneRANBP2chr12:57032890chr2:109400052ENST0000028319527293067_322331233225.0DomainPPIase cyclophilin-type
TgeneRANBP2chr12:57032890chr2:109400052ENST0000028319527291001_320631233225.0Region22 X 2 AA repeats of F-G
TgeneRANBP2chr12:57032890chr2:109400052ENST0000028319527292633_271031233225.0RegionNote=Required for E3 SUMO-ligase activity
TgeneRANBP2chr12:57032890chr2:109400052ENST0000028319527292633_276131233225.0RegionNote=2 X 50 AA approximate repeats
TgeneRANBP2chr12:57032890chr2:109400052ENST0000028319527291001_100231233225.0Repeat1
TgeneRANBP2chr12:57032890chr2:109400052ENST0000028319527291101_110231233225.0Repeat2
TgeneRANBP2chr12:57032890chr2:109400052ENST0000028319527291142_114331233225.0Repeat3
TgeneRANBP2chr12:57032890chr2:109400052ENST0000028319527291459_146031233225.0Repeat4
TgeneRANBP2chr12:57032890chr2:109400052ENST0000028319527291523_152431233225.0Repeat5
TgeneRANBP2chr12:57032890chr2:109400052ENST0000028319527291586_158731233225.0Repeat6
TgeneRANBP2chr12:57032890chr2:109400052ENST000002831952729165_20131233225.0RepeatTPR 4
TgeneRANBP2chr12:57032890chr2:109400052ENST0000028319527291852_185331233225.0Repeat7
TgeneRANBP2chr12:57032890chr2:109400052ENST0000028319527291861_186231233225.0Repeat8
TgeneRANBP2chr12:57032890chr2:109400052ENST0000028319527291900_190131233225.0Repeat9
TgeneRANBP2chr12:57032890chr2:109400052ENST0000028319527291938_193931233225.0Repeat10
TgeneRANBP2chr12:57032890chr2:109400052ENST0000028319527291961_196231233225.0Repeat11
TgeneRANBP2chr12:57032890chr2:109400052ENST0000028319527292260_226131233225.0Repeat12
TgeneRANBP2chr12:57032890chr2:109400052ENST0000028319527292516_251731233225.0Repeat13
TgeneRANBP2chr12:57032890chr2:109400052ENST0000028319527292535_253631233225.0Repeat14
TgeneRANBP2chr12:57032890chr2:109400052ENST0000028319527292545_254631233225.0Repeat15
TgeneRANBP2chr12:57032890chr2:109400052ENST00000283195272926_5931233225.0RepeatTPR 1
TgeneRANBP2chr12:57032890chr2:109400052ENST0000028319527292711_276131233225.0Repeat2
TgeneRANBP2chr12:57032890chr2:109400052ENST0000028319527292840_284131233225.0Repeat16
TgeneRANBP2chr12:57032890chr2:109400052ENST0000028319527292842_284331233225.0Repeat17
TgeneRANBP2chr12:57032890chr2:109400052ENST0000028319527292863_286431233225.0Repeat18
TgeneRANBP2chr12:57032890chr2:109400052ENST000002831952729287_31931233225.0RepeatTPR 5
TgeneRANBP2chr12:57032890chr2:109400052ENST0000028319527292880_288131233225.0Repeat19
TgeneRANBP2chr12:57032890chr2:109400052ENST0000028319527293106_310731233225.0Repeat20
TgeneRANBP2chr12:57032890chr2:109400052ENST000002831952729583_61631233225.0RepeatTPR 6
TgeneRANBP2chr12:57032890chr2:109400052ENST00000283195272960_9331233225.0RepeatTPR 2
TgeneRANBP2chr12:57032890chr2:109400052ENST000002831952729648_68131233225.0RepeatTPR 7
TgeneRANBP2chr12:57032890chr2:109400052ENST00000283195272994_12831233225.0RepeatTPR 3
TgeneRANBP2chr12:57032890chr2:109400052ENST0000028319527291351_138131233225.0Zinc fingerRanBP2-type 1
TgeneRANBP2chr12:57032890chr2:109400052ENST0000028319527291415_144431233225.0Zinc fingerRanBP2-type 2
TgeneRANBP2chr12:57032890chr2:109400052ENST0000028319527291479_150831233225.0Zinc fingerRanBP2-type 3
TgeneRANBP2chr12:57032890chr2:109400052ENST0000028319527291543_157231233225.0Zinc fingerRanBP2-type 4
TgeneRANBP2chr12:57032890chr2:109400052ENST0000028319527291606_163531233225.0Zinc fingerRanBP2-type 5
TgeneRANBP2chr12:57032890chr2:109400052ENST0000028319527291665_169431233225.0Zinc fingerRanBP2-type 6
TgeneRANBP2chr12:57032890chr2:109400052ENST0000028319527291724_175331233225.0Zinc fingerRanBP2-type 7
TgeneRANBP2chr12:57032890chr2:109400052ENST0000028319527291781_181031233225.0Zinc fingerRanBP2-type 8


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Fusion Gene Sequence for ATP5B-RANBP2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>7938_7938_1_ATP5B-RANBP2_ATP5B_chr12_57032890_ENST00000262030_RANBP2_chr2_109400052_ENST00000283195_length(transcript)=3756nt_BP=1540nt
GAGCAGGCGGCTGCGGTTGCTGCAGCCTTCAGTCTCCACCCGGACTACGCCATGTTGGGGTTTGTGGGTCGGGTGGCCGCTGCTCCGGCC
TCCGGGGCCTTGCGGAGACTCACCCCTTCAGCGTCGCTGCCCCCAGCTCAGCTCTTACTGCGGGCCGCTCCGACGGCGGTCCATCCTGTC
AGGGACTATGCGGCGCAAACATCTCCTTCGCCAAAAGCAGGCGCCGCCACCGGGCGCATCGTGGCGGTCATTGGCGCAGTGGTGGACGTC
CAGTTTGATGAGGGACTACCACCAATTCTAAATGCCCTGGAAGTGCAAGGCAGGGAGACCAGACTGGTTTTGGAGGTGGCCCAGCATTTG
GGTGAGAGCACAGTAAGGACTATTGCTATGGATGGTACAGAAGGCTTGGTTAGAGGCCAGAAAGTACTGGATTCTGGTGCACCAATCAAA
ATTCCTGTTGGTCCTGAGACTTTGGGCAGAATCATGAATGTCATTGGAGAACCTATTGATGAAAGAGGTCCCATCAAAACCAAACAATTT
GCTCCCATTCATGCTGAGGCTCCAGAGTTCATGGAAATGAGTGTTGAGCAGGAAATTCTGGTGACTGGTATCAAGGTTGTCGATCTGCTA
GCTCCCTATGCCAAGGGTGGCAAAATTGGGCTTTTTGGTGGTGCTGGAGTTGGCAAGACTGTACTGATCATGGAGTTAATCAACAATGTC
GCCAAAGCCCATGGTGGTTACTCTGTGTTTGCTGGTGTTGGTGAGAGGACCCGTGAAGGCAATGATTTATACCATGAAATGATTGAATCT
GGTGTTATCAACTTAAAAGATGCCACCTCTAAGGTAGCGCTGGTATATGGTCAAATGAATGAACCACCTGGTGCTCGTGCCCGGGTAGCT
CTGACTGGGCTGACTGTGGCTGAATACTTCAGAGACCAAGAAGGTCAAGATGTACTGCTATTTATTGATAACATCTTTCGCTTCACCCAG
GCTGGTTCAGAGGTGTCTGCATTATTGGGCCGAATCCCTTCTGCTGTGGGCTATCAGCCTACCCTGGCCACTGACATGGGTACTATGCAG
GAAAGAATTACCACTACCAAGAAGGGATCTATCACCTCTGTACAGGCTATCTATGTGCCTGCTGATGACTTGACTGACCCTGCCCCTGCT
ACTACGTTTGCCCATTTGGATGCTACCACTGTACTGTCGCGTGCCATTGCTGAGCTGGGCATCTATCCAGCTGTGGATCCTCTAGACTCC
ACCTCTCGTATCATGGATCCCAACATTGTTGGCAGTGAGCATTACGATGTTGCCCGTGGGGTGCAAAAGATCCTGCAGGACTACAAATCC
CTCCAGGATATCATTGCCATCCTGGGTATGGATGAACTTTCTGAGGAAGACAAGTTGACCGTGTCCCGTGCACGGAAAATACAGCGTTTC
TTGTCTCAGCCATTCCAGGTTGCTGAGGTCTTCACAGGTCATATGGGGAAGCTGGTACCCCTGAAGGAGACCATCAAAGGATTCCAGCAG
ATTTTGGCAGGGAGGAGATATCACCAAACATGATGGAACAGGCGGACAGTCCATTTATGGAGACAAATTTGAAGATGAAAATTTTGATGT
GAAACATACTGGTCCTGGTTTACTATCCATGGCCAATCAAGGCCAGAATACCAATAATTCTCAATTTGTTATAACACTGAAGAAAGCAGA
ACATTTGGACTTTAAGCATGTAGTATTTGGGTTTGTTAAGGATGGCATGGATACTGTGAAAAAGATTGAATCATTTGGTTCTCCCAAAGG
GTCTGTTTGTCGAAGAATAACTATCACAGAATGTGGACAGATATAAAATCATTGTTGTTCATAGAAAATTTCATCTGTATAAGCAGTTGG
ATTGAAGCTTAGCTATTACAATTTGATAGTTATGTTCAGCTTTTGAAAATGGACGTTTCCGATTTACAAATGTAAAATTGCAGCTTATAG
CTGTTGTCACTTTTTAATGTGTTATAATTGACCTTGCATGGTGTGAAATAAAAGTTTAAACACTGGTGTATTTCAGGTGTACTTGTGTTT
ATGTACTCCTGACGTATTAAAATGGAATAATACTAATCTTGTTAAAAGCAATAGACCTCAAACTATTGAAGGAATATGATATATGCAATT
TAATTTTAATTCCTTTTAAGATATTTGGACTTCCTGCATGGATATACTTACCATTTGAATAAAGGGACCACAACTTGGATAATTTAATTT
TAGGTTTGAAATATATTTGGTAATCTTAACTATTGGTGTACTCATTTATGCATAGAGACTCGTTTATGAATGGGTAGAGCCACAGAACGT
ATAGAGTTAACCAAAGTGCTCTTCTCTAGAATCTTTACACCTCCTGTGTGGTTACAAGTTAACTTTGTAAGTAGCGTACCTTCCTTCCTT
AAAATATCTAGCTTCCTGTGCCCTTTCATAGATATTCGATTAATTTTTACATTTTAAACAAGTTGACTATTTCCTTTAGGGGTTTTGTTT
CAAACTTTTCTGTCATCTGTCTCTACTACCTCAGAAACTGCAGCTTGGTTCTGATGATAGAAATTGAATTTTTCCTTGTAGTTATTGTGA
TAAAGTATGAATATTTTTAGAAAGTCTATACCATGTTCTTTCGTTAAAGATTTGCTTTATACAAGATTGTTGCAGTACCTTTTTCTGGTA
AATTTTGTAGCAGAAATAAAATGACAATTCCTAAGAGCCACTGACATCCAAAAAATTCATTACTTACGCTTCGGGTTCATTCTAAAGTAA
GGAAGACAATTTAAAGGCAGTAAATTCAAACTGCTGCATAATTTCCAGAGCTCCTAGTTTCTCAAGTTTGATACACACCAAAAACGTATT
TGGAAATGGCTTGTATCAAATGTTAGGCAAATTGCTAAAGAAAAGAGGATGTTCTTATTGGCCTACTCAATATGGAACTACAAAGAATCC
AGGTAGAACACAAAATTTTGTATATTGCAATTATGAATATTGACTGTCTTCCACCCATCTGTGTTCTTTCGGGTGAAATTACCTCATTTT
ATTTAGTGAGGAAAGACAGGTTTATTCCCTGTTACATGGGGATTTGGAAATTGGGTATCCTAAAGCAAGTAACTGTTCAACCACCAGTCA
AAAGAGGGGAGGGATGTTGTGCGAGTAATGAGTGATGGTATACCATCACCATTCCACTCGGCCACAAAGCCAGATACTTGAAATAAACCT
ACTCCAAATGTATCAGTTCAGTCTTGAACCATGGATTACATATGTTTACACTAAATATTTCAAATTGGCTTATTTGGAAATCTATGTAAT
ATAAACTGATGTAAAGTGTGTTGTAACTTTTCAGCTGAGACAGTTGATGCCTTCGTCATGATTTTAGAATAAATTCTTAAGTTAATGCAA
GTGCTTTTTAAGAGACTTTTTACAGATTTGTATGCTTTCCTAAAGCACTAAAGTTACAAATTAAAAAGCTTTAAAAACTTTGACCAAAAA
TTTGACAAAATGACATGTAAACTGACTTTTCCCGTATTAGTATTCCAAAGATGCTTAAAAGTGGCTTGTGGCATTTATGAGAAAGTCTTT
GTGTCACATTTCAGGAAAGGACTTTGATTTCTCTTTGTTATTTAATCACTGATGTGGTCTAAACCCACGATAATATGTATCTTTCCTTTT

>7938_7938_1_ATP5B-RANBP2_ATP5B_chr12_57032890_ENST00000262030_RANBP2_chr2_109400052_ENST00000283195_length(amino acids)=503AA_BP=
MLGFVGRVAAAPASGALRRLTPSASLPPAQLLLRAAPTAVHPVRDYAAQTSPSPKAGAATGRIVAVIGAVVDVQFDEGLPPILNALEVQG
RETRLVLEVAQHLGESTVRTIAMDGTEGLVRGQKVLDSGAPIKIPVGPETLGRIMNVIGEPIDERGPIKTKQFAPIHAEAPEFMEMSVEQ
EILVTGIKVVDLLAPYAKGGKIGLFGGAGVGKTVLIMELINNVAKAHGGYSVFAGVGERTREGNDLYHEMIESGVINLKDATSKVALVYG
QMNEPPGARARVALTGLTVAEYFRDQEGQDVLLFIDNIFRFTQAGSEVSALLGRIPSAVGYQPTLATDMGTMQERITTTKKGSITSVQAI
YVPADDLTDPAPATTFAHLDATTVLSRAIAELGIYPAVDPLDSTSRIMDPNIVGSEHYDVARGVQKILQDYKSLQDIIAILGMDELSEED

--------------------------------------------------------------
>7938_7938_2_ATP5B-RANBP2_ATP5B_chr12_57032890_ENST00000552919_RANBP2_chr2_109400052_ENST00000283195_length(transcript)=3682nt_BP=1466nt
GGACTACGCCATGTTGGGGTTTGTGGGTCGGGTGGCCGCTGCTCCGGCCTCCGGGGCCTTGCGGAGACTCACCCCTTCAGCGTCGCTGCC
CCCAGCTCAGCTCTTACTGCGGGCCGCTCCGACGGCGGTCCATCCTGTCAGGGACTATGCGGCGCAAACATCTCCTTCGCCAAAAGCAGG
CGCCGCCACCGGGCGCATCGTGGCGGTCATTGGCGCAGTGGTGGACGTCCAGTTTGATGAGGGACTACCACCAATTCTAAATGCCCTGGA
AGTGCAAGGCAGGGAGACCAGACTGGTTTTGGAGGTGGCCCAGCATTTGGGTGAGAGCACAGTAAGGACTATTGCTATGGATGGTACAGA
AGGCTTGGTTAGAGGCCAGAAAGTACTGGATTCTGGTGCACCAATCAAAATTCCTGTTGGTCCTGAGACTTTGGGCAGAATCATGAATGT
CATTGGAGAACCTATTGATGAAAGAGGTCCCATCAAAACCAAACAATTTGCTCCCATTCATGCTGAGGCTCCAGAGTTCATGGAAATGAG
TGTTGAGCAGGAAATTCTGGTGACTGGTATCAAGGTTGTCGATCTGCTAGCTCCCTATGCCAAGGGTGGCAAAATTGGGCTTTTTGGTGG
TGCTGGAGTTGGCAAGACTGTACTGATCATGGAGTTAATCAACAATGTCGCCAAAGCCCATGGTGGTTACTCTGTGTTTGCTGGTGTTGG
TGAGAGGACCCGTGAAGGCAATGATTTATACCATGAAATGATTGAATCTGGTGTTATCAACTTAAAAGATGCCACCTCTAAGGTAGCGCT
GGTATATGGTCAAATGAATGAACCACCTGGTGCTCGTGCCCGGGTAGCTCTGACTGGGCTGACTGTGGCTGAATACTTCAGAGACCAAGA
AGGTCAAGATGTACTGCTATTTATTGATGTGTCTGCATTATTGGGCCGAATCCCTTCTGCTGTGGGCTATCAGCCTACCCTGGCCACTGA
CATGGGTACTATGCAGGAAAGAATTACCACTACCAAGAAGGGATCTATCACCTCTGTACAGGCTATCTATGTGCCTGCTGATGACTTGAC
TGACCCTGCCCCTGCTACTACGTTTGCCCATTTGGATGCTACCACTGTACTGTCGCGTGCCATTGCTGAGCTGGGCATCTATCCAGCTGT
GGATCCTCTAGACTCCACCTCTCGTATCATGGATCCCAACATTGTTGGCAGTGAGCATTACGATGTTGCCCGTGGGGTGCAAAAGATCCT
GCAGGACTACAAATCCCTCCAGGATATCATTGCCATCCTGGGTATGGATGAACTTTCTGAGGAAGACAAGTTGACCGTGTCCCGTGCACG
GAAAATACAGCGTTTCTTGTCTCAGCCATTCCAGGTTGCTGAGGTCTTCACAGGTCATATGGGGAAGCTGGTACCCCTGAAGGAGACCAT
CAAAGGATTCCAGCAGATTTTGGCAGGGAGGAGATATCACCAAACATGATGGAACAGGCGGACAGTCCATTTATGGAGACAAATTTGAAG
ATGAAAATTTTGATGTGAAACATACTGGTCCTGGTTTACTATCCATGGCCAATCAAGGCCAGAATACCAATAATTCTCAATTTGTTATAA
CACTGAAGAAAGCAGAACATTTGGACTTTAAGCATGTAGTATTTGGGTTTGTTAAGGATGGCATGGATACTGTGAAAAAGATTGAATCAT
TTGGTTCTCCCAAAGGGTCTGTTTGTCGAAGAATAACTATCACAGAATGTGGACAGATATAAAATCATTGTTGTTCATAGAAAATTTCAT
CTGTATAAGCAGTTGGATTGAAGCTTAGCTATTACAATTTGATAGTTATGTTCAGCTTTTGAAAATGGACGTTTCCGATTTACAAATGTA
AAATTGCAGCTTATAGCTGTTGTCACTTTTTAATGTGTTATAATTGACCTTGCATGGTGTGAAATAAAAGTTTAAACACTGGTGTATTTC
AGGTGTACTTGTGTTTATGTACTCCTGACGTATTAAAATGGAATAATACTAATCTTGTTAAAAGCAATAGACCTCAAACTATTGAAGGAA
TATGATATATGCAATTTAATTTTAATTCCTTTTAAGATATTTGGACTTCCTGCATGGATATACTTACCATTTGAATAAAGGGACCACAAC
TTGGATAATTTAATTTTAGGTTTGAAATATATTTGGTAATCTTAACTATTGGTGTACTCATTTATGCATAGAGACTCGTTTATGAATGGG
TAGAGCCACAGAACGTATAGAGTTAACCAAAGTGCTCTTCTCTAGAATCTTTACACCTCCTGTGTGGTTACAAGTTAACTTTGTAAGTAG
CGTACCTTCCTTCCTTAAAATATCTAGCTTCCTGTGCCCTTTCATAGATATTCGATTAATTTTTACATTTTAAACAAGTTGACTATTTCC
TTTAGGGGTTTTGTTTCAAACTTTTCTGTCATCTGTCTCTACTACCTCAGAAACTGCAGCTTGGTTCTGATGATAGAAATTGAATTTTTC
CTTGTAGTTATTGTGATAAAGTATGAATATTTTTAGAAAGTCTATACCATGTTCTTTCGTTAAAGATTTGCTTTATACAAGATTGTTGCA
GTACCTTTTTCTGGTAAATTTTGTAGCAGAAATAAAATGACAATTCCTAAGAGCCACTGACATCCAAAAAATTCATTACTTACGCTTCGG
GTTCATTCTAAAGTAAGGAAGACAATTTAAAGGCAGTAAATTCAAACTGCTGCATAATTTCCAGAGCTCCTAGTTTCTCAAGTTTGATAC
ACACCAAAAACGTATTTGGAAATGGCTTGTATCAAATGTTAGGCAAATTGCTAAAGAAAAGAGGATGTTCTTATTGGCCTACTCAATATG
GAACTACAAAGAATCCAGGTAGAACACAAAATTTTGTATATTGCAATTATGAATATTGACTGTCTTCCACCCATCTGTGTTCTTTCGGGT
GAAATTACCTCATTTTATTTAGTGAGGAAAGACAGGTTTATTCCCTGTTACATGGGGATTTGGAAATTGGGTATCCTAAAGCAAGTAACT
GTTCAACCACCAGTCAAAAGAGGGGAGGGATGTTGTGCGAGTAATGAGTGATGGTATACCATCACCATTCCACTCGGCCACAAAGCCAGA
TACTTGAAATAAACCTACTCCAAATGTATCAGTTCAGTCTTGAACCATGGATTACATATGTTTACACTAAATATTTCAAATTGGCTTATT
TGGAAATCTATGTAATATAAACTGATGTAAAGTGTGTTGTAACTTTTCAGCTGAGACAGTTGATGCCTTCGTCATGATTTTAGAATAAAT
TCTTAAGTTAATGCAAGTGCTTTTTAAGAGACTTTTTACAGATTTGTATGCTTTCCTAAAGCACTAAAGTTACAAATTAAAAAGCTTTAA
AAACTTTGACCAAAAATTTGACAAAATGACATGTAAACTGACTTTTCCCGTATTAGTATTCCAAAGATGCTTAAAAGTGGCTTGTGGCAT
TTATGAGAAAGTCTTTGTGTCACATTTCAGGAAAGGACTTTGATTTCTCTTTGTTATTTAATCACTGATGTGGTCTAAACCCACGATAAT

>7938_7938_2_ATP5B-RANBP2_ATP5B_chr12_57032890_ENST00000552919_RANBP2_chr2_109400052_ENST00000283195_length(amino acids)=492AA_BP=
MLGFVGRVAAAPASGALRRLTPSASLPPAQLLLRAAPTAVHPVRDYAAQTSPSPKAGAATGRIVAVIGAVVDVQFDEGLPPILNALEVQG
RETRLVLEVAQHLGESTVRTIAMDGTEGLVRGQKVLDSGAPIKIPVGPETLGRIMNVIGEPIDERGPIKTKQFAPIHAEAPEFMEMSVEQ
EILVTGIKVVDLLAPYAKGGKIGLFGGAGVGKTVLIMELINNVAKAHGGYSVFAGVGERTREGNDLYHEMIESGVINLKDATSKVALVYG
QMNEPPGARARVALTGLTVAEYFRDQEGQDVLLFIDVSALLGRIPSAVGYQPTLATDMGTMQERITTTKKGSITSVQAIYVPADDLTDPA
PATTFAHLDATTVLSRAIAELGIYPAVDPLDSTSRIMDPNIVGSEHYDVARGVQKILQDYKSLQDIIAILGMDELSEEDKLTVSRARKIQ

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Fusion Gene PPI Analysis for ATP5B-RANBP2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
TgeneRANBP2chr12:57032890chr2:109400052ENST0000028319527292147_22873123.03225.0BICD2
TgeneRANBP2chr12:57032890chr2:109400052ENST0000028319527292686_27613123.03225.0SUMO1
TgeneRANBP2chr12:57032890chr2:109400052ENST0000028319527292631_26353123.03225.0sumoylated RANGAP1
TgeneRANBP2chr12:57032890chr2:109400052ENST0000028319527292633_26853123.03225.0UBE2I


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ATP5B-RANBP2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ATP5B-RANBP2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource