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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:SCAF4-RAB10 (FusionGDB2 ID:79418)

Fusion Gene Summary for SCAF4-RAB10

check button Fusion gene summary
Fusion gene informationFusion gene name: SCAF4-RAB10
Fusion gene ID: 79418
HgeneTgene
Gene symbol

SCAF4

RAB10

Gene ID

57466

10890

Gene nameSR-related CTD associated factor 4RAB10, member RAS oncogene family
SynonymsSFRS15|SRA4-
Cytomap

21q22.11

2p23.3

Type of geneprotein-codingprotein-coding
DescriptionSR-related and CTD-associated factor 4CTD-binding SR-like protein rA4SR-like CTD-associated factor 4pre-mRNA splicing SR protein rA4splicing factor serine alanine 15splicing factor, arginine/serine-rich 15ras-related protein Rab-10GTP-binding protein RAB10ras-related GTP-binding protein
Modification date2020031420200327
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000286835, ENST00000399804, 
ENST00000434667, 		ENST00000462003, 
ENST00000264710, 
Fusion gene scores* DoF score21 X 11 X 5=115515 X 10 X 6=900
# samples 2015
** MAII scorelog2(20/1155*10)=-2.5298209465287
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(15/900*10)=-2.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SCAF4 [Title/Abstract] AND RAB10 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointSCAF4(33057361)-RAB10(26321530), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneSCAF4

GO:2000805

negative regulation of termination of RNA polymerase II transcription, poly(A)-coupled

31104839


check buttonFusion gene breakpoints across SCAF4 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across RAB10 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4OVTCGA-13-0890SCAF4chr21

33057361

-RAB10chr2

26321530

+


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Fusion Gene ORF analysis for SCAF4-RAB10

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000286835ENST00000462003SCAF4chr21

33057361

-RAB10chr2

26321530

+
5CDS-3UTRENST00000399804ENST00000462003SCAF4chr21

33057361

-RAB10chr2

26321530

+
5CDS-3UTRENST00000434667ENST00000462003SCAF4chr21

33057361

-RAB10chr2

26321530

+
In-frameENST00000286835ENST00000264710SCAF4chr21

33057361

-RAB10chr2

26321530

+
In-frameENST00000399804ENST00000264710SCAF4chr21

33057361

-RAB10chr2

26321530

+
In-frameENST00000434667ENST00000264710SCAF4chr21

33057361

-RAB10chr2

26321530

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000399804SCAF4chr2133057361-ENST00000264710RAB10chr226321530+571428053023280992
ENST00000286835SCAF4chr2133057361-ENST00000264710RAB10chr226321530+5780287130233461014
ENST00000434667SCAF4chr2133057361-ENST00000264710RAB10chr226321530+562827191953194999

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000399804ENST00000264710SCAF4chr2133057361-RAB10chr226321530+0.0001612210.9998387
ENST00000286835ENST00000264710SCAF4chr2133057361-RAB10chr226321530+0.0001735320.9998265
ENST00000434667ENST00000264710SCAF4chr2133057361-RAB10chr226321530+8.95E-050.9999105

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Fusion Genomic Features for SCAF4-RAB10


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
SCAF4chr2133057361-RAB10chr226321530+5.88E-091
SCAF4chr2133057361-RAB10chr226321530+5.88E-091

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for SCAF4-RAB10


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr21:33057361/chr2:26321530)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSCAF4chr21:33057361chr2:26321530ENST00000286835-1920155_1588291148.0Compositional biasNote=Poly-Pro
HgeneSCAF4chr21:33057361chr2:26321530ENST00000286835-1920304_3118291148.0Compositional biasNote=Poly-Ala
HgeneSCAF4chr21:33057361chr2:26321530ENST00000286835-1920313_3168291148.0Compositional biasNote=Poly-Pro
HgeneSCAF4chr21:33057361chr2:26321530ENST00000286835-1920716_7238291148.0Compositional biasNote=Poly-Pro
HgeneSCAF4chr21:33057361chr2:26321530ENST00000286835-1920740_7468291148.0Compositional biasNote=Poly-Pro
HgeneSCAF4chr21:33057361chr2:26321530ENST00000399804-1920155_1588071126.0Compositional biasNote=Poly-Pro
HgeneSCAF4chr21:33057361chr2:26321530ENST00000399804-1920304_3118071126.0Compositional biasNote=Poly-Ala
HgeneSCAF4chr21:33057361chr2:26321530ENST00000399804-1920313_3168071126.0Compositional biasNote=Poly-Pro
HgeneSCAF4chr21:33057361chr2:26321530ENST00000399804-1920716_7238071126.0Compositional biasNote=Poly-Pro
HgeneSCAF4chr21:33057361chr2:26321530ENST00000399804-1920740_7468071126.0Compositional biasNote=Poly-Pro
HgeneSCAF4chr21:33057361chr2:26321530ENST00000434667-1819155_1588141133.0Compositional biasNote=Poly-Pro
HgeneSCAF4chr21:33057361chr2:26321530ENST00000434667-1819304_3118141133.0Compositional biasNote=Poly-Ala
HgeneSCAF4chr21:33057361chr2:26321530ENST00000434667-1819313_3168141133.0Compositional biasNote=Poly-Pro
HgeneSCAF4chr21:33057361chr2:26321530ENST00000434667-1819716_7238141133.0Compositional biasNote=Poly-Pro
HgeneSCAF4chr21:33057361chr2:26321530ENST00000434667-1819740_7468141133.0Compositional biasNote=Poly-Pro
HgeneSCAF4chr21:33057361chr2:26321530ENST00000286835-19201_1398291148.0DomainCID
HgeneSCAF4chr21:33057361chr2:26321530ENST00000286835-1920508_5828291148.0DomainRRM
HgeneSCAF4chr21:33057361chr2:26321530ENST00000399804-19201_1398071126.0DomainCID
HgeneSCAF4chr21:33057361chr2:26321530ENST00000399804-1920508_5828071126.0DomainRRM
HgeneSCAF4chr21:33057361chr2:26321530ENST00000434667-18191_1398141133.0DomainCID
HgeneSCAF4chr21:33057361chr2:26321530ENST00000434667-1819508_5828141133.0DomainRRM
TgeneRAB10chr21:33057361chr2:26321530ENST0000026471006122_12542201.0Nucleotide bindingGTP
TgeneRAB10chr21:33057361chr2:26321530ENST0000026471006152_15442201.0Nucleotide bindingGTP
TgeneRAB10chr21:33057361chr2:26321530ENST000002647100664_6842201.0Nucleotide bindingGTP

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSCAF4chr21:33057361chr2:26321530ENST00000286835-1920957_9668291148.0Compositional biasNote=Poly-Gln
HgeneSCAF4chr21:33057361chr2:26321530ENST00000399804-1920957_9668071126.0Compositional biasNote=Poly-Gln
HgeneSCAF4chr21:33057361chr2:26321530ENST00000434667-1819957_9668141133.0Compositional biasNote=Poly-Gln
TgeneRAB10chr21:33057361chr2:26321530ENST000002647100638_4642201.0MotifEffector region
TgeneRAB10chr21:33057361chr2:26321530ENST000002647100618_2442201.0Nucleotide bindingGTP
TgeneRAB10chr21:33057361chr2:26321530ENST000002647100635_4142201.0Nucleotide bindingGTP


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Fusion Gene Sequence for SCAF4-RAB10


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>79418_79418_1_SCAF4-RAB10_SCAF4_chr21_33057361_ENST00000286835_RAB10_chr2_26321530_ENST00000264710_length(transcript)=5780nt_BP=2871nt
CGCTGGAGAGAGGGAGAGAGAGGCCCGCCCGCTCGCCGGCCGGGCCAGTGTGAGCCAGTGCGTGAGGGCGCGGGGGGCCGTGTCAGCGAG
ACGCAGAGCGCAGCCGCCACCACCAAACGGACATGTTGAAGACCAGCGCTGCCGCCGCCTCCTTTTCCTCATCCTGCGAACGGGACTGAG
AGGGGGCCCGCCACCTCTCCGCCTCTGCCTCGGCCGCCCGCCTCGCCGCTTCGGGCGCAGCCTCTTCCTGCCCGGGCCTCGGACTCCGCC
GCTCGTCGCCTCCCCCCGGCCACCAGGCCCGGCTGGTTTCCCAGCCCCGCTCCGCCGCGGCGCGAGGTCTATGTGACCGGCGGGCCCGGA
GCAGCCGCCGCCGCAGCGCGAACATGGACGCCGTCAACGCCTTCAACCAGGAGCTCTTTTCGCTTATGGATATGAAACCTCCCATCTCTA
GAGCCAAGATGATTCTCATCACTAAAGCTGCTATTAAAGCTATTAAGCTTTATAAGCATGTAGTTCAAATAGTAGAAAAGTTCATCAAAA
AGTGTAAACCAGAATACAAGGTTCCGGGATTATATGTAATTGACTCAATTGTGCGACAGTCTCGTCATCAGTTTGGAACTGATAAAGATG
TTTTTGGGCCAAGATTCTCTAAAAACATAACTGCCACATTCCAATATTTATATCTTTGTCCATCTGAAGATAAGAGTAAAATAGTTCGTG
TGCTGAACCTTTGGCAAAAAAATGGAGTGTTCAAAATTGAAATTATTCAACCTCTTTTGGACATGGCAGCGGGAACCAGTAATGCAGCCC
CAGTAGCAGAAAATGTTACCAATAATGAAGGCTCACCTCCACCTCCAGTAAAAGTTTCTTCTGAACCTCCCACACAAGCCACTCCAAACT
CCGTCCCAGCTGTACCACAGTTGCCCAGCTCTGATGCTTTTGCTGCTGTGGCTCAGCTGTTTCAGACAACTCAAGGCCAACAGCTTCAGC
AGATCCTTCAGACTTTTCAACAGCCTCCAAAACCACAGTCTCCTGCCCTTGACAATGCTGTGATGGCTCAGGTTCAGGCTATCACAGCTC
AGTTAAAGACAACTCCTACACAACCATCTGAACAAAAAGCTGCTTTCCCCCCACCTGAACAGAAAACTGCATTTGACAAGAAGTTGCTTG
ATAGATTTGACTATGATGATGAGCCAGAAGCTGTGGAAGAATCAAAGAAAGAGGATACCACTGCCGTCACCACGACAGCACCTGCTGCCG
CAGTACCCCCTGCACCCACCGCCACCGTGCCTGCTGCTGCTGCACCCGCTGCTGCCTCTCCTCCTCCTCCACAGGCACCATTTGGCTTTC
CTGGAGATGGCATGCAGCAGCCAGCATACACACAGCATCAAAATATGGATCAGTTTCAGCCACGAATGATGGGAATACAACAGGATCCAA
TGCACCATCAGGTTCCACTTCCTCCTAATGGACAAATGCCAGGATTTGGACTTCTTCCTACACCTCCATTTCCTCCCATGGCTCAGCCTG
TGATTCCTCCAACTCCACCAGTGCAGCAGCCTTTCCAAGCTTCTTTTCAGGCACAAAATGAACCACTTACACAGAAGCCGCATCAGCAGG
AAATGGAAGTAGAACAACCTTGTATTCAAGAGGTTAAGCGACATATGTCTGATAACAGAAAGTCAAGATCTAGGTCAGCATCCAGGTCAC
CAAAAAGGAGGCGATCTAGATCTGGTTCTAGATCTCGAAGGTCTCGGCATCGACGTTCTCGATCTCGGTCCAGGGATAGACGCCGACATT
CTCCCCGATCTCGATCTCAAGAAAGACGGGATCGAGAAAAAGAGAGAGAACGTCGACAAAAAGGCCTCCCTCAAGTGAAACCGGAAACTG
CAAGTGTTTGCAGTACTACCCTCTGGGTGGGGCAGCTGGACAAAAGAACTACTCAGCAGGATGTTGCCAGTCTCTTGGAAGAGTTTGGTC
CAATTGAATCAATTAATATGATTCCTCCCAGGGGTTGTGCCTATATTGTTATGGTTCATAGGCAAGATGCCTATCGTGCCCTGCAGAAAC
TGAGCCGAGGAAACTATAAAGTGAACCAGAAATCCATAAAGATTGCCTGGGCCTTAAACAAAGGAATAAAGGCAGATTATAAGCAGTATT
GGGATGTAGAACTTGGTGTTACTTATATTCCATGGGACAAAGTCAAGCCTGAGGAACTGGAGAGTTTTTGTGAAGGAGGAATGTTGGACA
GTGACACACTTAACCCAGATTGGAAAGGAATTCCTAAGAAGCCTGAAAATGAAGTTGCTCAAAATGGAGGTGCTGAAACCTCACACACAG
AACCAGTATCACCCATACCTAAACCATTACCTGTGCCTGTCCCTCCTATTCCTGTTCCTGCACCTATAACAGTGCCACCTCCACAGGTCC
CACCACATCAACCGGGTCCACCTGTAGTTGGTGCTCTCCAGCCGCCTGCTTTCACGCCTCCTCTGGGAATACCGCCTCCAGGCTTTGGTC
CTGGTGTTCCTCCTCCCCCTCCTCCTCCACCATTTTTGCGCCCAGGATTCAACCCAATGCATTTACCACCAGGTTTTCTGCCTCCTGGAC
CCCCACCTCCTATAACTCCACCAGTATCCATTCCTCCTCCTCACACTCCACCAATAAGCATCCCAAACTCTACTATCGCTGGTATAAATG
AAGACACTACAAAAGACTTATCTATTGGAAATCCCATTCCAACAGTGGTGTCTGGGGCTAGAGGAAACGCCGAGTCTGGTGACAGCGTGA
AAATGTATGGCTCTGCCGTGCCACCTGCTGCACCCACGAATCTGCCCACCCCTCCTGTAACCCAGCCTGTTTCACTTCTTGGAATAGACT
TCAAGATCAAAACAGTTGAATTACAAGGAAAGAAGATCAAGCTACAGATATGGGATACAGCAGGCCAGGAGCGATTTCACACCATCACAA
CCTCCTACTACAGAGGCGCAATGGGTATCATGCTAGTATATGACATCACCAATGGTAAAAGTTTTGAAAACATCAGCAAATGGCTTAGAA
ACATAGATGAGCATGCCAATGAAGATGTGGAAAGAATGTTACTAGGAAACAAGTGTGATATGGACGACAAAAGAGTTGTACCTAAAGGAA
AAGGAGAACAGATTGCAAGGGAGCATGGTATTAGGTTTTTTGAGACTAGTGCAAAAGCAAATATAAACATCGAAAAGGCGTTCCTCACGT
TAGCTGAAGATATCCTTCGAAAGACCCCTGTAAAAGAGCCCAACAGTGAAAATGTAGATATCAGCAGTGGAGGAGGCGTGACAGGCTGGA
AGAGCAAATGCTGCTGAGCATTCTCCTGTTCCATCAGTTGCCATCCACTACCCCGTTTTCTCTTCTTGCTGCAAAATAAACCACTCTGTC
CATTTTTAACTCTAAACAGATATTTTTGTTTCTCATCTTAACTATCCAAGCCACCTATTTTATTTGTTCTTTCATCTGTGACTGCTTGCT
GACTTTATCATAATTTTCTTCAAACAAAAAAATGTATAGAAAAATCATGTCTGTGAGTTCATTTTTAAATGTACTTGCTCAGCTCAACTG
CATTTCAGTTGTATTATAGTCCAGTTCTTATCAACATTAAAACCTATAGCAATCATTTCAAATCTATTCTGCAAATTGTATAAGAATAAA
GTTAGAATTAACAATTTTATTTTGTACAACAGTGGAATTTTCTGTCATGGATAATGTGCTTGAGTCCCTATAATCTATAGACATGTGATA
GCAAAAGAAACAAACAAAAGCCAGGAAAACACTCATTTTCGCCTTGAATATGTAAATGGGATTAATTTTGTCCTGTGCCTTATGTGGAAA
GGAACTTCTTTGGTTTTCCTTTTTTGTTCTGGTGGAAGCATGTGCAGGAGACATATCATCCAAACATAAACCATTAAAATGTTTGTGGTT
TGCTTGGCTGTAATTTTCAAAGTAGTTAATTGAGGACAAAGGGTAATGCAGAAGTGATAGCTTTGGTTTGCTGAGTCTTGTTTTAAGTGG
CCTTGATATTTAAAACTATTCCTGCCACCATTTCTTCTCCTTGGCCACTTCTTCCTTGCGTCTCCCTGCATGCTGCTTTATTTGCTTCTC
CCTCCCCAACCACCTCATGGTATATTTAAGAGTGAAAGGGACAAACTAGTAGGTTTGTCAAGTTTAATATAAAGCACTGATGTAACTTGC
TAGGTAAACGGAAAGATAAGTTCTAACTGCCTACTATCCAATGTCAGTTAATTGGTGTCTTCCCCCCTCATTTGCTCTCTTCCCTAAAAT
GTGTCCCAGATGCCTTCATTTGCTGTTTTACTTCTATGTTCTGCTTTTCCTCCTCTCTTTGTTCCCTTCCTGTCTATCCATTGAGTTTAT
GAAATGGAAGAGTTAACTGCATGCACTAGTGTTTGGAGGGTGTTGTGGTTTGTCTTTCTAATTAGGTGTATAGCCTATTCACTTTCCTAG
AATAAATCTCTTAACCTAAATTTGAGTAGTCTGCATTTTGGCAACTCCTCTAGCAGCTTGGTAGCCTAGTACAGGTTGTTTTTTTAAAAA
AGGAAAAGCAGGAAGGAGGAGTGAATTTTATTAACATGTTTGCCAAATGTATTGAGATTTGGCCTCTGAAGAACACTTTTTCAGTGTTAA
GTTTCTTTACCTTAAGATTCAGAAATACTTTAGAATATTATTAATTTTAAGTCCTGTCTTTACATCCTTTTGGAAAACTTGTATTACCAT
GGGTTTGGAAAAAGGACAACGAAAGGCTTTTCATGTAAAGATAAGATCTTTAGCTATCTCTAACCCTGTCCTTTTTTCACTGCATTTTTT
CTAGTTTTGCTTCATTGCTTATCATTAGGATAGGGTAAGTGAAGTTTGCTATGCTGCTAGCATCCTAAGATGATACCTTTGTTGAAAGAA
TTGTGAATAGCATGATTCATTTCTAGCAGAGGCTGAGTTTAGGACAGCAGCTTCCATTGAGAAGTCTTTCTGTGTCGTGAATAGCATTTT
AATGACCTCTTGGCTCACATAAGCAAACAACATAGGGACGTATCTGCTATGAAAATCCACAAATTTTTCAGATAGTGCCCTAAAAACAAT
TTTATATGCCTCACTGGTTGTTATTCTTAGGTTATTCCCACACTTGACTTTATCATTGTTTACTACTAGTAAAAAGCAGCATTGCCAAAT
AATCCCTAATTTTCCACTAAAAATATAATGAAATGATGTTAAGCTTTTTGAAAAGTTTAGGTTAAACCTACTGTTGTTAGATTAATGTAT
TTGTTGCTTCCCTTTATCTGGAATGTGGCATTAGCTTTTTTATTTTAACCCTCTTTAATTCTTATTCAATTCCATGACTTAAGGTTGGAG
AGCTAAACACTGGGATTTTTGGATAACAGACTGACAGTTTTGCATAATTATAATCGGCATTGTACATAGAAAGGATATGGCTACCTTTTG
TTAAATCTGCACTTTCTAAATATCAAAAAAGGGAAATGAAGTATAAATCAATTTTTGTATAATCTGTTTGAAACATGAGTTTTATTTGCT
TAATATTAGGGCTTTGCCCCTTTTCTGTAAGTCTCTTGGGATCCTGTGTAGAAGCTGTTCTCATTAAACACCAAACAGTTAAGTCCATTC
TCTGGTACTAGCTACAAATTCGGTTTCATATTCTACTTAACAATTTAAATAAACTGAAATATTTCTAGATGGTCTACTTCTGTTCATATA

>79418_79418_1_SCAF4-RAB10_SCAF4_chr21_33057361_ENST00000286835_RAB10_chr2_26321530_ENST00000264710_length(amino acids)=1014AA_BP=856
MVSQPRSAAARGLCDRRARSSRRRSANMDAVNAFNQELFSLMDMKPPISRAKMILITKAAIKAIKLYKHVVQIVEKFIKKCKPEYKVPGL
YVIDSIVRQSRHQFGTDKDVFGPRFSKNITATFQYLYLCPSEDKSKIVRVLNLWQKNGVFKIEIIQPLLDMAAGTSNAAPVAENVTNNEG
SPPPPVKVSSEPPTQATPNSVPAVPQLPSSDAFAAVAQLFQTTQGQQLQQILQTFQQPPKPQSPALDNAVMAQVQAITAQLKTTPTQPSE
QKAAFPPPEQKTAFDKKLLDRFDYDDEPEAVEESKKEDTTAVTTTAPAAAVPPAPTATVPAAAAPAAASPPPPQAPFGFPGDGMQQPAYT
QHQNMDQFQPRMMGIQQDPMHHQVPLPPNGQMPGFGLLPTPPFPPMAQPVIPPTPPVQQPFQASFQAQNEPLTQKPHQQEMEVEQPCIQE
VKRHMSDNRKSRSRSASRSPKRRRSRSGSRSRRSRHRRSRSRSRDRRRHSPRSRSQERRDREKERERRQKGLPQVKPETASVCSTTLWVG
QLDKRTTQQDVASLLEEFGPIESINMIPPRGCAYIVMVHRQDAYRALQKLSRGNYKVNQKSIKIAWALNKGIKADYKQYWDVELGVTYIP
WDKVKPEELESFCEGGMLDSDTLNPDWKGIPKKPENEVAQNGGAETSHTEPVSPIPKPLPVPVPPIPVPAPITVPPPQVPPHQPGPPVVG
ALQPPAFTPPLGIPPPGFGPGVPPPPPPPPFLRPGFNPMHLPPGFLPPGPPPPITPPVSIPPPHTPPISIPNSTIAGINEDTTKDLSIGN
PIPTVVSGARGNAESGDSVKMYGSAVPPAAPTNLPTPPVTQPVSLLGIDFKIKTVELQGKKIKLQIWDTAGQERFHTITTSYYRGAMGIM
LVYDITNGKSFENISKWLRNIDEHANEDVERMLLGNKCDMDDKRVVPKGKGEQIAREHGIRFFETSAKANINIEKAFLTLAEDILRKTPV

--------------------------------------------------------------
>79418_79418_2_SCAF4-RAB10_SCAF4_chr21_33057361_ENST00000399804_RAB10_chr2_26321530_ENST00000264710_length(transcript)=5714nt_BP=2805nt
CGCTGGAGAGAGGGAGAGAGAGGCCCGCCCGCTCGCCGGCCGGGCCAGTGTGAGCCAGTGCGTGAGGGCGCGGGGGGCCGTGTCAGCGAG
ACGCAGAGCGCAGCCGCCACCACCAAACGGACATGTTGAAGACCAGCGCTGCCGCCGCCTCCTTTTCCTCATCCTGCGAACGGGACTGAG
AGGGGGCCCGCCACCTCTCCGCCTCTGCCTCGGCCGCCCGCCTCGCCGCTTCGGGCGCAGCCTCTTCCTGCCCGGGCCTCGGACTCCGCC
GCTCGTCGCCTCCCCCCGGCCACCAGGCCCGGCTGGTTTCCCAGCCCCGCTCCGCCGCGGCGCGAGGTCTATGTGACCGGCGGGCCCGGA
GCAGCCGCCGCCGCAGCGCGAACATGGACGCCGTCAACGCCTTCAACCAGGAGCTCTTTTCGCTTATGGATATGAAACCTCCCATCTCTA
GAGCCAAGATGATTCTCATCACTAAAGCTGCTATTAAAGCTATTAAGCTTTATAAGCATGTAGTTCAAATAGTAGAAAAGTTCATCAAAA
AGTGTAAACCAGAATACAAGGTTCCGGGATTATATGTAATTGACTCAATTGTGCGACAGTCTCGTCATCAGTTTGGAACTGATAAAGATG
TTTTTGGGCCAAGATTCTCTAAAAACATAACTGCCACATTCCAATATTTATATCTTTGTCCATCTGAAGATAAGAGTAAAATAGTTCGTG
TGCTGAACCTTTGGCAAAAAAATGGAGTGTTCAAAATTGAAATTATTCAACCTCTTTTGGACATGGCAGCGGGAACCAGTAATGCAGCCC
CAGTAGCAGAAAATGTTACCAATAATGAAGGCTCACCTCCACCTCCAGTAAAAGTTTCTTCTGAACCTCCCACACAAGCCACTCCAAACT
CCGTCCCAGCTGTACCACAGTTGCCCAGCTCTGATGCTTTTGCTGCTGTGGCTCAGCTGTTTCAGACAACTCAAGGCCAACAGCTTCAGC
AGATCCTTCAGACTTTTCAACAGCCTCCAAAACCACAGTCTCCTGCCCTTGACAATGCTGTGATGGCTCAGGTTCAGGCTATCACAGCTC
AGTTAAAGACAACTCCTACACAACCATCTGAACAAAAAGCTGCTTTCCCCCCACCTGAACAGAAAACTGCATTTGACAAGAAGTTGCTTG
ATAGATTTGACTATGATGATGAGCCAGAAGCTGTGGAAGAATCAAAGAAAGAGGATACCACTGCCGTCACCACGACAGCACCTGCTGCCG
CAGTACCCCCTGCACCCACCGCCACCGTGCCTGCTGCTGCTGCACCCGCTGCTGCCTCTCCTCCTCCTCCACAGGCACCATTTGGCTTTC
CTGGAGATGGCATGCAGCAGCCAGCATACACACAGCATCAAAATATGGATCAGTTTCAGCCACGAATGATGGGAATACAACAGGATCCAA
TGCACCATCAGGTTCCACTTCCTCCTAATGGACAAATGCCAGGATTTGGACTTCTTCCTACACCTCCATTTCCTCCCATGGCTCAGCCTG
TGATTCCTCCAACTCCACCAGTGCAGCAGCCTTTCCAAGCTTCTTTTCAGGCACAAAATGAACCACTTACACAGAAGCCGCATCAGCAGG
AAATGGAAGTAGAACAACCTTGTATTCAAGAGGTTAAGCGACATATGTCTGATAACAGAAAGTCAAGATCTAGGTCAGCATCCAGGTCAC
CAAAAAGGAGGCGATCTAGATCTGGTTCTAGATCTCGAAGGTCTCGGCATCGACGTTCTCGATCTCGGTCCAGGGATAGACGCCGACATT
CTCCCCGATCTCGATCTCAAGAAAGACGGGATCGAGAAAAAGAGAGAGAACGTCGACAAAAAGGCCTCCCTCAAGTGAAACCGGAAACTG
CAAGTGTTTGCAGTACTACCCTCTGGGTGGGGCAGCTGGACAAAAGAACTACTCAGCAGGATGTTGCCAGTCTCTTGGAAGAGTTTGGTC
CAATTGAATCAATTAATATGATTCCTCCCAGGGGTTGTGCCTATATTGTTATGGTTCATAGGCAAGATGCCTATCGTGCCCTGCAGAAAC
TGAGCCGAGGAAACTATAAAGTGAACCAGAAATCCATAAAGATTGCCTGGGCCTTAAACAAAGGAATAAAGGCAGATTATAAGCAGTATT
GGGATGTAGAACTTGGTGTTACTTATATTCCATGGGACAAAGTCAAGCCTGAGGAACTGGAGAGTTTTTGTGAAGGAGGAATGTTGGACA
GTGACACACTTAACCCAGATTGGAAAGGAATTCCTAAGAAGCCTGAAAATGAAGTTGCTCAAAATGGAGGTGCTGAAACCTCACACACAG
AACCAGTATCACCCATACCTAAACCATTACCTGTGCCTGTCCCTCCTATTCCTGTTCCTGCACCTATAACAGTGCCACCTCCACAGGTCC
CACCACATCAACCGGGTCCACCTGTAGTTGGTGCTCTCCAGCCGCCTGCTTTCACGCCTCCTCTGGGAATACCGCCTCCAGGCTTTGGTC
CTGGTGTTCCTCCTCCCCCTCCTCCTCCACCATTTTTGCGCCCAGGATTCAACCCAATGCATTTACCACCAGGTTTTCTGCCTCCTGGAC
CCCCACCTCCTATAACTCCACCAGTATCCATTCCTCCTCCTCACACTCCACCAATAAGCATCCCAAACTTGGTGTCTGGGGCTAGAGGAA
ACGCCGAGTCTGGTGACAGCGTGAAAATGTATGGCTCTGCCGTGCCACCTGCTGCACCCACGAATCTGCCCACCCCTCCTGTAACCCAGC
CTGTTTCACTTCTTGGAATAGACTTCAAGATCAAAACAGTTGAATTACAAGGAAAGAAGATCAAGCTACAGATATGGGATACAGCAGGCC
AGGAGCGATTTCACACCATCACAACCTCCTACTACAGAGGCGCAATGGGTATCATGCTAGTATATGACATCACCAATGGTAAAAGTTTTG
AAAACATCAGCAAATGGCTTAGAAACATAGATGAGCATGCCAATGAAGATGTGGAAAGAATGTTACTAGGAAACAAGTGTGATATGGACG
ACAAAAGAGTTGTACCTAAAGGAAAAGGAGAACAGATTGCAAGGGAGCATGGTATTAGGTTTTTTGAGACTAGTGCAAAAGCAAATATAA
ACATCGAAAAGGCGTTCCTCACGTTAGCTGAAGATATCCTTCGAAAGACCCCTGTAAAAGAGCCCAACAGTGAAAATGTAGATATCAGCA
GTGGAGGAGGCGTGACAGGCTGGAAGAGCAAATGCTGCTGAGCATTCTCCTGTTCCATCAGTTGCCATCCACTACCCCGTTTTCTCTTCT
TGCTGCAAAATAAACCACTCTGTCCATTTTTAACTCTAAACAGATATTTTTGTTTCTCATCTTAACTATCCAAGCCACCTATTTTATTTG
TTCTTTCATCTGTGACTGCTTGCTGACTTTATCATAATTTTCTTCAAACAAAAAAATGTATAGAAAAATCATGTCTGTGAGTTCATTTTT
AAATGTACTTGCTCAGCTCAACTGCATTTCAGTTGTATTATAGTCCAGTTCTTATCAACATTAAAACCTATAGCAATCATTTCAAATCTA
TTCTGCAAATTGTATAAGAATAAAGTTAGAATTAACAATTTTATTTTGTACAACAGTGGAATTTTCTGTCATGGATAATGTGCTTGAGTC
CCTATAATCTATAGACATGTGATAGCAAAAGAAACAAACAAAAGCCAGGAAAACACTCATTTTCGCCTTGAATATGTAAATGGGATTAAT
TTTGTCCTGTGCCTTATGTGGAAAGGAACTTCTTTGGTTTTCCTTTTTTGTTCTGGTGGAAGCATGTGCAGGAGACATATCATCCAAACA
TAAACCATTAAAATGTTTGTGGTTTGCTTGGCTGTAATTTTCAAAGTAGTTAATTGAGGACAAAGGGTAATGCAGAAGTGATAGCTTTGG
TTTGCTGAGTCTTGTTTTAAGTGGCCTTGATATTTAAAACTATTCCTGCCACCATTTCTTCTCCTTGGCCACTTCTTCCTTGCGTCTCCC
TGCATGCTGCTTTATTTGCTTCTCCCTCCCCAACCACCTCATGGTATATTTAAGAGTGAAAGGGACAAACTAGTAGGTTTGTCAAGTTTA
ATATAAAGCACTGATGTAACTTGCTAGGTAAACGGAAAGATAAGTTCTAACTGCCTACTATCCAATGTCAGTTAATTGGTGTCTTCCCCC
CTCATTTGCTCTCTTCCCTAAAATGTGTCCCAGATGCCTTCATTTGCTGTTTTACTTCTATGTTCTGCTTTTCCTCCTCTCTTTGTTCCC
TTCCTGTCTATCCATTGAGTTTATGAAATGGAAGAGTTAACTGCATGCACTAGTGTTTGGAGGGTGTTGTGGTTTGTCTTTCTAATTAGG
TGTATAGCCTATTCACTTTCCTAGAATAAATCTCTTAACCTAAATTTGAGTAGTCTGCATTTTGGCAACTCCTCTAGCAGCTTGGTAGCC
TAGTACAGGTTGTTTTTTTAAAAAAGGAAAAGCAGGAAGGAGGAGTGAATTTTATTAACATGTTTGCCAAATGTATTGAGATTTGGCCTC
TGAAGAACACTTTTTCAGTGTTAAGTTTCTTTACCTTAAGATTCAGAAATACTTTAGAATATTATTAATTTTAAGTCCTGTCTTTACATC
CTTTTGGAAAACTTGTATTACCATGGGTTTGGAAAAAGGACAACGAAAGGCTTTTCATGTAAAGATAAGATCTTTAGCTATCTCTAACCC
TGTCCTTTTTTCACTGCATTTTTTCTAGTTTTGCTTCATTGCTTATCATTAGGATAGGGTAAGTGAAGTTTGCTATGCTGCTAGCATCCT
AAGATGATACCTTTGTTGAAAGAATTGTGAATAGCATGATTCATTTCTAGCAGAGGCTGAGTTTAGGACAGCAGCTTCCATTGAGAAGTC
TTTCTGTGTCGTGAATAGCATTTTAATGACCTCTTGGCTCACATAAGCAAACAACATAGGGACGTATCTGCTATGAAAATCCACAAATTT
TTCAGATAGTGCCCTAAAAACAATTTTATATGCCTCACTGGTTGTTATTCTTAGGTTATTCCCACACTTGACTTTATCATTGTTTACTAC
TAGTAAAAAGCAGCATTGCCAAATAATCCCTAATTTTCCACTAAAAATATAATGAAATGATGTTAAGCTTTTTGAAAAGTTTAGGTTAAA
CCTACTGTTGTTAGATTAATGTATTTGTTGCTTCCCTTTATCTGGAATGTGGCATTAGCTTTTTTATTTTAACCCTCTTTAATTCTTATT
CAATTCCATGACTTAAGGTTGGAGAGCTAAACACTGGGATTTTTGGATAACAGACTGACAGTTTTGCATAATTATAATCGGCATTGTACA
TAGAAAGGATATGGCTACCTTTTGTTAAATCTGCACTTTCTAAATATCAAAAAAGGGAAATGAAGTATAAATCAATTTTTGTATAATCTG
TTTGAAACATGAGTTTTATTTGCTTAATATTAGGGCTTTGCCCCTTTTCTGTAAGTCTCTTGGGATCCTGTGTAGAAGCTGTTCTCATTA
AACACCAAACAGTTAAGTCCATTCTCTGGTACTAGCTACAAATTCGGTTTCATATTCTACTTAACAATTTAAATAAACTGAAATATTTCT

>79418_79418_2_SCAF4-RAB10_SCAF4_chr21_33057361_ENST00000399804_RAB10_chr2_26321530_ENST00000264710_length(amino acids)=992AA_BP=834
MVSQPRSAAARGLCDRRARSSRRRSANMDAVNAFNQELFSLMDMKPPISRAKMILITKAAIKAIKLYKHVVQIVEKFIKKCKPEYKVPGL
YVIDSIVRQSRHQFGTDKDVFGPRFSKNITATFQYLYLCPSEDKSKIVRVLNLWQKNGVFKIEIIQPLLDMAAGTSNAAPVAENVTNNEG
SPPPPVKVSSEPPTQATPNSVPAVPQLPSSDAFAAVAQLFQTTQGQQLQQILQTFQQPPKPQSPALDNAVMAQVQAITAQLKTTPTQPSE
QKAAFPPPEQKTAFDKKLLDRFDYDDEPEAVEESKKEDTTAVTTTAPAAAVPPAPTATVPAAAAPAAASPPPPQAPFGFPGDGMQQPAYT
QHQNMDQFQPRMMGIQQDPMHHQVPLPPNGQMPGFGLLPTPPFPPMAQPVIPPTPPVQQPFQASFQAQNEPLTQKPHQQEMEVEQPCIQE
VKRHMSDNRKSRSRSASRSPKRRRSRSGSRSRRSRHRRSRSRSRDRRRHSPRSRSQERRDREKERERRQKGLPQVKPETASVCSTTLWVG
QLDKRTTQQDVASLLEEFGPIESINMIPPRGCAYIVMVHRQDAYRALQKLSRGNYKVNQKSIKIAWALNKGIKADYKQYWDVELGVTYIP
WDKVKPEELESFCEGGMLDSDTLNPDWKGIPKKPENEVAQNGGAETSHTEPVSPIPKPLPVPVPPIPVPAPITVPPPQVPPHQPGPPVVG
ALQPPAFTPPLGIPPPGFGPGVPPPPPPPPFLRPGFNPMHLPPGFLPPGPPPPITPPVSIPPPHTPPISIPNLVSGARGNAESGDSVKMY
GSAVPPAAPTNLPTPPVTQPVSLLGIDFKIKTVELQGKKIKLQIWDTAGQERFHTITTSYYRGAMGIMLVYDITNGKSFENISKWLRNID
EHANEDVERMLLGNKCDMDDKRVVPKGKGEQIAREHGIRFFETSAKANINIEKAFLTLAEDILRKTPVKEPNSENVDISSGGGVTGWKSK

--------------------------------------------------------------
>79418_79418_3_SCAF4-RAB10_SCAF4_chr21_33057361_ENST00000434667_RAB10_chr2_26321530_ENST00000264710_length(transcript)=5628nt_BP=2719nt
CACCACCAAACGGACATGTTGAAGACCAGCGCTGCCGCCGCCTCCTTTTCCTCATCCTGCGAACGGGACTGAGAGGGGGCCCGCCACCTC
TCCGCCTCTGCCTCGGCCGCCCGCCTCGCCGCTTCGGGCGCAGCCTCTTCCTGCCCGGGCCTCGGACTCCGCCGCTCGTCGCCTCCCCCC
GGCCACCAGGCCCGGCTGGTTTCCCAGCCCCGCTCCGCCGCGGCGCGAGGTCTATGTGACCGGCGGGCCCGGAGCAGCCGCCGCCGCAGC
GCGAACATGGACGCCGTCAACGCCTTCAACCAGGAGCTCTTTTCGCTTATGGATATGAAACCTCCCATCTCTAGAGCCAAGATGATTCTC
ATCACTAAAGCTGCTATTAAAGCTATTAAGTGTAAACCAGAATACAAGGTTCCGGGATTATATGTAATTGACTCAATTGTGCGACAGTCT
CGTCATCAGTTTGGAACTGATAAAGATGTTTTTGGGCCAAGATTCTCTAAAAACATAACTGCCACATTCCAATATTTATATCTTTGTCCA
TCTGAAGATAAGAGTAAAATAGTTCGTGTGCTGAACCTTTGGCAAAAAAATGGAGTGTTCAAAATTGAAATTATTCAACCTCTTTTGGAC
ATGGCAGCGGGAACCAGTAATGCAGCCCCAGTAGCAGAAAATGTTACCAATAATGAAGGCTCACCTCCACCTCCAGTAAAAGTTTCTTCT
GAACCTCCCACACAAGCCACTCCAAACTCCGTCCCAGCTGTACCACAGTTGCCCAGCTCTGATGCTTTTGCTGCTGTGGCTCAGCTGTTT
CAGACAACTCAAGGCCAACAGCTTCAGCAGATCCTTCAGACTTTTCAACAGCCTCCAAAACCACAGTCTCCTGCCCTTGACAATGCTGTG
ATGGCTCAGGTTCAGGCTATCACAGCTCAGTTAAAGACAACTCCTACACAACCATCTGAACAAAAAGCTGCTTTCCCCCCACCTGAACAG
AAAACTGCATTTGACAAGAAGTTGCTTGATAGATTTGACTATGATGATGAGCCAGAAGCTGTGGAAGAATCAAAGAAAGAGGATACCACT
GCCGTCACCACGACAGCACCTGCTGCCGCAGTACCCCCTGCACCCACCGCCACCGTGCCTGCTGCTGCTGCACCCGCTGCTGCCTCTCCT
CCTCCTCCACAGGCACCATTTGGCTTTCCTGGAGATGGCATGCAGCAGCCAGCATACACACAGCATCAAAATATGGATCAGTTTCAGCCA
CGAATGATGGGAATACAACAGGATCCAATGCACCATCAGGTTCCACTTCCTCCTAATGGACAAATGCCAGGATTTGGACTTCTTCCTACA
CCTCCATTTCCTCCCATGGCTCAGCCTGTGATTCCTCCAACTCCACCAGTGCAGCAGCCTTTCCAAGCTTCTTTTCAGGCACAAAATGAA
CCACTTACACAGAAGCCGCATCAGCAGGAAATGGAAGTAGAACAACCTTGTATTCAAGAGGTTAAGCGACATATGTCTGATAACAGAAAG
TCAAGATCTAGGTCAGCATCCAGGTCACCAAAAAGGAGGCGATCTAGATCTGGTTCTAGATCTCGAAGGTCTCGGCATCGACGTTCTCGA
TCTCGGTCCAGGGATAGACGCCGACATTCTCCCCGATCTCGATCTCAAGAAAGACGGGATCGAGAAAAAGAGAGAGAACGTCGACAAAAA
GGCCTCCCTCAAGTGAAACCGGAAACTGCAAGTGTTTGCAGTACTACCCTCTGGGTGGGGCAGCTGGACAAAAGAACTACTCAGCAGGAT
GTTGCCAGTCTCTTGGAAGAGTTTGGTCCAATTGAATCAATTAATATGATTCCTCCCAGGGGTTGTGCCTATATTGTTATGGTTCATAGG
CAAGATGCCTATCGTGCCCTGCAGAAACTGAGCCGAGGAAACTATAAAGTGAACCAGAAATCCATAAAGATTGCCTGGGCCTTAAACAAA
GGAATAAAGGCAGATTATAAGCAGTATTGGGATGTAGAACTTGGTGTTACTTATATTCCATGGGACAAAGTCAAGCCTGAGGAACTGGAG
AGTTTTTGTGAAGGAGGAATGTTGGACAGTGACACACTTAACCCAGATTGGAAAGGAATTCCTAAGAAGCCTGAAAATGAAGTTGCTCAA
AATGGAGGTGCTGAAACCTCACACACAGAACCAGTATCACCCATACCTAAACCATTACCTGTGCCTGTCCCTCCTATTCCTGTTCCTGCA
CCTATAACAGTGCCACCTCCACAGGTCCCACCACATCAACCGGGTCCACCTGTAGTTGGTGCTCTCCAGCCGCCTGCTTTCACGCCTCCT
CTGGGAATACCGCCTCCAGGCTTTGGTCCTGGTGTTCCTCCTCCCCCTCCTCCTCCACCATTTTTGCGCCCAGGATTCAACCCAATGCAT
TTACCACCAGGTTTTCTGCCTCCTGGACCCCCACCTCCTATAACTCCACCAGTATCCATTCCTCCTCCTCACACTCCACCAATAAGCATC
CCAAACTCTACTATCGCTGGTATAAATGAAGACACTACAAAAGACTTATCTATTGGAAATCCCATTCCAACAGTGGTGTCTGGGGCTAGA
GGAAACGCCGAGTCTGGTGACAGCGTGAAAATGTATGGCTCTGCCGTGCCACCTGCTGCACCCACGAATCTGCCCACCCCTCCTGTAACC
CAGCCTGTTTCACTTCTTGGAATAGACTTCAAGATCAAAACAGTTGAATTACAAGGAAAGAAGATCAAGCTACAGATATGGGATACAGCA
GGCCAGGAGCGATTTCACACCATCACAACCTCCTACTACAGAGGCGCAATGGGTATCATGCTAGTATATGACATCACCAATGGTAAAAGT
TTTGAAAACATCAGCAAATGGCTTAGAAACATAGATGAGCATGCCAATGAAGATGTGGAAAGAATGTTACTAGGAAACAAGTGTGATATG
GACGACAAAAGAGTTGTACCTAAAGGAAAAGGAGAACAGATTGCAAGGGAGCATGGTATTAGGTTTTTTGAGACTAGTGCAAAAGCAAAT
ATAAACATCGAAAAGGCGTTCCTCACGTTAGCTGAAGATATCCTTCGAAAGACCCCTGTAAAAGAGCCCAACAGTGAAAATGTAGATATC
AGCAGTGGAGGAGGCGTGACAGGCTGGAAGAGCAAATGCTGCTGAGCATTCTCCTGTTCCATCAGTTGCCATCCACTACCCCGTTTTCTC
TTCTTGCTGCAAAATAAACCACTCTGTCCATTTTTAACTCTAAACAGATATTTTTGTTTCTCATCTTAACTATCCAAGCCACCTATTTTA
TTTGTTCTTTCATCTGTGACTGCTTGCTGACTTTATCATAATTTTCTTCAAACAAAAAAATGTATAGAAAAATCATGTCTGTGAGTTCAT
TTTTAAATGTACTTGCTCAGCTCAACTGCATTTCAGTTGTATTATAGTCCAGTTCTTATCAACATTAAAACCTATAGCAATCATTTCAAA
TCTATTCTGCAAATTGTATAAGAATAAAGTTAGAATTAACAATTTTATTTTGTACAACAGTGGAATTTTCTGTCATGGATAATGTGCTTG
AGTCCCTATAATCTATAGACATGTGATAGCAAAAGAAACAAACAAAAGCCAGGAAAACACTCATTTTCGCCTTGAATATGTAAATGGGAT
TAATTTTGTCCTGTGCCTTATGTGGAAAGGAACTTCTTTGGTTTTCCTTTTTTGTTCTGGTGGAAGCATGTGCAGGAGACATATCATCCA
AACATAAACCATTAAAATGTTTGTGGTTTGCTTGGCTGTAATTTTCAAAGTAGTTAATTGAGGACAAAGGGTAATGCAGAAGTGATAGCT
TTGGTTTGCTGAGTCTTGTTTTAAGTGGCCTTGATATTTAAAACTATTCCTGCCACCATTTCTTCTCCTTGGCCACTTCTTCCTTGCGTC
TCCCTGCATGCTGCTTTATTTGCTTCTCCCTCCCCAACCACCTCATGGTATATTTAAGAGTGAAAGGGACAAACTAGTAGGTTTGTCAAG
TTTAATATAAAGCACTGATGTAACTTGCTAGGTAAACGGAAAGATAAGTTCTAACTGCCTACTATCCAATGTCAGTTAATTGGTGTCTTC
CCCCCTCATTTGCTCTCTTCCCTAAAATGTGTCCCAGATGCCTTCATTTGCTGTTTTACTTCTATGTTCTGCTTTTCCTCCTCTCTTTGT
TCCCTTCCTGTCTATCCATTGAGTTTATGAAATGGAAGAGTTAACTGCATGCACTAGTGTTTGGAGGGTGTTGTGGTTTGTCTTTCTAAT
TAGGTGTATAGCCTATTCACTTTCCTAGAATAAATCTCTTAACCTAAATTTGAGTAGTCTGCATTTTGGCAACTCCTCTAGCAGCTTGGT
AGCCTAGTACAGGTTGTTTTTTTAAAAAAGGAAAAGCAGGAAGGAGGAGTGAATTTTATTAACATGTTTGCCAAATGTATTGAGATTTGG
CCTCTGAAGAACACTTTTTCAGTGTTAAGTTTCTTTACCTTAAGATTCAGAAATACTTTAGAATATTATTAATTTTAAGTCCTGTCTTTA
CATCCTTTTGGAAAACTTGTATTACCATGGGTTTGGAAAAAGGACAACGAAAGGCTTTTCATGTAAAGATAAGATCTTTAGCTATCTCTA
ACCCTGTCCTTTTTTCACTGCATTTTTTCTAGTTTTGCTTCATTGCTTATCATTAGGATAGGGTAAGTGAAGTTTGCTATGCTGCTAGCA
TCCTAAGATGATACCTTTGTTGAAAGAATTGTGAATAGCATGATTCATTTCTAGCAGAGGCTGAGTTTAGGACAGCAGCTTCCATTGAGA
AGTCTTTCTGTGTCGTGAATAGCATTTTAATGACCTCTTGGCTCACATAAGCAAACAACATAGGGACGTATCTGCTATGAAAATCCACAA
ATTTTTCAGATAGTGCCCTAAAAACAATTTTATATGCCTCACTGGTTGTTATTCTTAGGTTATTCCCACACTTGACTTTATCATTGTTTA
CTACTAGTAAAAAGCAGCATTGCCAAATAATCCCTAATTTTCCACTAAAAATATAATGAAATGATGTTAAGCTTTTTGAAAAGTTTAGGT
TAAACCTACTGTTGTTAGATTAATGTATTTGTTGCTTCCCTTTATCTGGAATGTGGCATTAGCTTTTTTATTTTAACCCTCTTTAATTCT
TATTCAATTCCATGACTTAAGGTTGGAGAGCTAAACACTGGGATTTTTGGATAACAGACTGACAGTTTTGCATAATTATAATCGGCATTG
TACATAGAAAGGATATGGCTACCTTTTGTTAAATCTGCACTTTCTAAATATCAAAAAAGGGAAATGAAGTATAAATCAATTTTTGTATAA
TCTGTTTGAAACATGAGTTTTATTTGCTTAATATTAGGGCTTTGCCCCTTTTCTGTAAGTCTCTTGGGATCCTGTGTAGAAGCTGTTCTC
ATTAAACACCAAACAGTTAAGTCCATTCTCTGGTACTAGCTACAAATTCGGTTTCATATTCTACTTAACAATTTAAATAAACTGAAATAT

>79418_79418_3_SCAF4-RAB10_SCAF4_chr21_33057361_ENST00000434667_RAB10_chr2_26321530_ENST00000264710_length(amino acids)=999AA_BP=841
MVSQPRSAAARGLCDRRARSSRRRSANMDAVNAFNQELFSLMDMKPPISRAKMILITKAAIKAIKCKPEYKVPGLYVIDSIVRQSRHQFG
TDKDVFGPRFSKNITATFQYLYLCPSEDKSKIVRVLNLWQKNGVFKIEIIQPLLDMAAGTSNAAPVAENVTNNEGSPPPPVKVSSEPPTQ
ATPNSVPAVPQLPSSDAFAAVAQLFQTTQGQQLQQILQTFQQPPKPQSPALDNAVMAQVQAITAQLKTTPTQPSEQKAAFPPPEQKTAFD
KKLLDRFDYDDEPEAVEESKKEDTTAVTTTAPAAAVPPAPTATVPAAAAPAAASPPPPQAPFGFPGDGMQQPAYTQHQNMDQFQPRMMGI
QQDPMHHQVPLPPNGQMPGFGLLPTPPFPPMAQPVIPPTPPVQQPFQASFQAQNEPLTQKPHQQEMEVEQPCIQEVKRHMSDNRKSRSRS
ASRSPKRRRSRSGSRSRRSRHRRSRSRSRDRRRHSPRSRSQERRDREKERERRQKGLPQVKPETASVCSTTLWVGQLDKRTTQQDVASLL
EEFGPIESINMIPPRGCAYIVMVHRQDAYRALQKLSRGNYKVNQKSIKIAWALNKGIKADYKQYWDVELGVTYIPWDKVKPEELESFCEG
GMLDSDTLNPDWKGIPKKPENEVAQNGGAETSHTEPVSPIPKPLPVPVPPIPVPAPITVPPPQVPPHQPGPPVVGALQPPAFTPPLGIPP
PGFGPGVPPPPPPPPFLRPGFNPMHLPPGFLPPGPPPPITPPVSIPPPHTPPISIPNSTIAGINEDTTKDLSIGNPIPTVVSGARGNAES
GDSVKMYGSAVPPAAPTNLPTPPVTQPVSLLGIDFKIKTVELQGKKIKLQIWDTAGQERFHTITTSYYRGAMGIMLVYDITNGKSFENIS
KWLRNIDEHANEDVERMLLGNKCDMDDKRVVPKGKGEQIAREHGIRFFETSAKANINIEKAFLTLAEDILRKTPVKEPNSENVDISSGGG

--------------------------------------------------------------

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Fusion Gene PPI Analysis for SCAF4-RAB10


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for SCAF4-RAB10


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for SCAF4-RAB10


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource