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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:SCAMP1-ARSB (FusionGDB2 ID:79461)

Fusion Gene Summary for SCAMP1-ARSB

check button Fusion gene summary
Fusion gene informationFusion gene name: SCAMP1-ARSB
Fusion gene ID: 79461
HgeneTgene
Gene symbol

SCAMP1

ARSB

Gene ID

9522

411

Gene namesecretory carrier membrane protein 1arylsulfatase B
SynonymsSCAMP|SCAMP37ASB|G4S|MPS6
Cytomap

5q14.1

5q14.1

Type of geneprotein-codingprotein-coding
Descriptionsecretory carrier-associated membrane protein 1arylsulfatase BN-acetylgalactosamine-4-sulfatase
Modification date2020031320200313
UniProtAcc.

P15848

Ensembl transtripts involved in fusion geneENST00000339292, ENST00000538629, 
ENST00000264914, ENST00000396151, 
ENST00000565165, ENST00000521800, 
Fusion gene scores* DoF score4 X 4 X 4=6410 X 8 X 5=400
# samples 511
** MAII scorelog2(5/64*10)=-0.356143810225275
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(11/400*10)=-1.86249647625006
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SCAMP1 [Title/Abstract] AND ARSB [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointSCAMP1(77745857)-ARSB(78135249), # samples:2
Anticipated loss of major functional domain due to fusion event.SCAMP1-ARSB seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneSCAMP1

GO:0015031

protein transport

15840657


check buttonFusion gene breakpoints across SCAMP1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across ARSB (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-HF-A5NB-01ASCAMP1chr5

77745857

+ARSBchr5

78135249

-
ChimerDB4STADTCGA-HF-A5NB-01ASCAMP1chr5

77745859

+ARSBchr5

78135248

-
ChimerDB4STADTCGA-HF-A5NBSCAMP1chr5

77717784

+ARSBchr5

78135249

-
ChimerDB4STADTCGA-HF-A5NBSCAMP1chr5

77745857

+ARSBchr5

78135249

-


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Fusion Gene ORF analysis for SCAMP1-ARSB

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000339292ENST00000264914SCAMP1chr5

77745857

+ARSBchr5

78135249

-
3UTR-3CDSENST00000339292ENST00000264914SCAMP1chr5

77745859

+ARSBchr5

78135248

-
3UTR-3CDSENST00000339292ENST00000264914SCAMP1chr5

77717784

+ARSBchr5

78135249

-
3UTR-3CDSENST00000339292ENST00000396151SCAMP1chr5

77745857

+ARSBchr5

78135249

-
3UTR-3CDSENST00000339292ENST00000396151SCAMP1chr5

77745859

+ARSBchr5

78135248

-
3UTR-3CDSENST00000339292ENST00000396151SCAMP1chr5

77717784

+ARSBchr5

78135249

-
3UTR-3CDSENST00000339292ENST00000565165SCAMP1chr5

77745857

+ARSBchr5

78135249

-
3UTR-3CDSENST00000339292ENST00000565165SCAMP1chr5

77745859

+ARSBchr5

78135248

-
3UTR-3CDSENST00000339292ENST00000565165SCAMP1chr5

77717784

+ARSBchr5

78135249

-
3UTR-intronENST00000339292ENST00000521800SCAMP1chr5

77745857

+ARSBchr5

78135249

-
3UTR-intronENST00000339292ENST00000521800SCAMP1chr5

77745859

+ARSBchr5

78135248

-
3UTR-intronENST00000339292ENST00000521800SCAMP1chr5

77717784

+ARSBchr5

78135249

-
5CDS-intronENST00000538629ENST00000521800SCAMP1chr5

77745857

+ARSBchr5

78135249

-
5CDS-intronENST00000538629ENST00000521800SCAMP1chr5

77745859

+ARSBchr5

78135248

-
5CDS-intronENST00000538629ENST00000521800SCAMP1chr5

77717784

+ARSBchr5

78135249

-
Frame-shiftENST00000538629ENST00000264914SCAMP1chr5

77745857

+ARSBchr5

78135249

-
Frame-shiftENST00000538629ENST00000264914SCAMP1chr5

77745859

+ARSBchr5

78135248

-
Frame-shiftENST00000538629ENST00000396151SCAMP1chr5

77745857

+ARSBchr5

78135249

-
Frame-shiftENST00000538629ENST00000396151SCAMP1chr5

77745859

+ARSBchr5

78135248

-
Frame-shiftENST00000538629ENST00000565165SCAMP1chr5

77745857

+ARSBchr5

78135249

-
Frame-shiftENST00000538629ENST00000565165SCAMP1chr5

77745859

+ARSBchr5

78135248

-
In-frameENST00000538629ENST00000264914SCAMP1chr5

77717784

+ARSBchr5

78135249

-
In-frameENST00000538629ENST00000396151SCAMP1chr5

77717784

+ARSBchr5

78135249

-
In-frameENST00000538629ENST00000565165SCAMP1chr5

77717784

+ARSBchr5

78135249

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000538629SCAMP1chr577717784+ENST00000264914ARSBchr578135249-44377891571248363
ENST00000538629SCAMP1chr577717784+ENST00000396151ARSBchr578135249-1464789157888243
ENST00000538629SCAMP1chr577717784+ENST00000565165ARSBchr578135249-920789157888243

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000538629ENST00000264914SCAMP1chr577717784+ARSBchr578135249-0.0001409170.9998591
ENST00000538629ENST00000396151SCAMP1chr577717784+ARSBchr578135249-0.0003837860.99961615
ENST00000538629ENST00000565165SCAMP1chr577717784+ARSBchr578135249-0.0003639260.99963605

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Fusion Genomic Features for SCAMP1-ARSB


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for SCAMP1-ARSB


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr5:77745857/chr5:78135249)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.ARSB

P15848

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Removes sulfate groups from chondroitin-4-sulfate (C4S) and regulates its degradation (PubMed:19306108). Involved in the regulation of cell adhesion, cell migration and invasion in colonic epithelium (PubMed:19306108). In the central nervous system, is a regulator of neurite outgrowth and neuronal plasticity, acting through the control of sulfate glycosaminoglycans and neurocan levels (By similarity). {ECO:0000250|UniProtKB:P50430, ECO:0000269|PubMed:19306108}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for SCAMP1-ARSB


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>79461_79461_1_SCAMP1-ARSB_SCAMP1_chr5_77717784_ENST00000538629_ARSB_chr5_78135249_ENST00000264914_length(transcript)=4437nt_BP=789nt
GCACCGGGCATGCTCAGTGGCGCGGCCGGCTGGGTGGCCCGCGAGCTGCACCCGGATCTGCTCGGCGGCGGCGACGTGAGCGCGCAGGGG
GGCGGCGGCCTCGCCTCGTCTCTCTCTCTGCGCCTGGGTCGGGTGGGTGACGCCGAGAGCCAGAGAGATGTCGGATTTCGACAGTAACCC
GTTTGCCGACCCGGATCTCAACAATCCCTTCAAGGATCCATCAGTTACACAAGTGACAAGAAATGTTCCACCAGGACTTGATGAATATAA
TCCATTCTCGGATTCTAGAACACCTCCACCAGGCGGTGTGAAGATGCCTAATGTACCCAATACACAACCAGCAATAATGAAACCAACAGA
GGAACATCCAGCTTATACACAGATTGCAAAGGAACATGCATTGGCCCAAGCTGAACTTCTTAAGCGCCAGGAAGAACTAGAAAGAAAAGC
CGCAGAATTAGATCGTCGGGAACGAGAAATGCAAAACCTCAGTCAACATGGTAGAAAAAATAATTGGCCACCTCTTCCTAGCAATTTTCC
TGTCGGACCTTGTTTCTATCAGGATTTTTCTGTAGACATTCCTGTAGAATTCCAAAAGACAGTAAAGCTTATGTACTACTTGTGGATGTT
CCATGCAGTAACACTGTTTCTAAATATCTTCGGATGCTTGGCTTGGTTTTGTGTTGATTCTGCAAGAGCGGTTGATTTTGGATTGAGTAT
CCTGTGGTTCTTGCTTTTTACTCCTTGTTCATTTGTCTGTTGGTACAGACCACTTTATGGAGCTTTCAGTGAAGGAAGCCCATCCCCCAG
AATTGAGCTGCTGCATAATATTGACCCGAACTTCGTGGACTCTTCACCGTGTCCCAGGAACAGCATGGCTCCAGCAAAGGATGACTCTTC
TCTTCCAGAATATTCAGCCTTTAACACATCTGTCCATGCTGCAATTAGACATGGAAATTGGAAACTCCTCACGGGCTACCCAGGCTGTGG
TTACTGGTTCCCTCCACCGTCTCAATACAATGTTTCTGAGATACCCTCATCAGACCCACCAACCAAGACCCTCTGGCTCTTTGATATTGA
TCGGGACCCTGAAGAAAGACATGACCTGTCCAGAGAATATCCTCACATCGTCACAAAGCTCCTGTCCCGCCTACAGTTCTACCATAAACA
CTCAGTCCCCGTGTACTTCCCTGCACAGGACCCCCGCTGTGATCCCAAGGCCACTGGGGTGTGGGGCCCTTGGATGTAGGATTTCAGGGA
GGCTAGAAAACCTTTCAATTGGAAGTTGGACCTCAGGCCTTTTCTCACGACTCTTGTCTCATTTGTTATCCCAACCTGGGTTCACTTGGC
CCTTCTCTTGCTCTTAAACCACACCGAGGTGTCTAATTTCAACCCCTAATGCATTTAAGAAGCTGATAAAATCTGCAACACTCCTGCTGT
TGGCTGGAGCATGTGTCTAGAGGTGGGGGTGGCTGGGTTTATCCCCCTTTCCTAAGCCTTGGGACAGCTGGGAACTTAACTTGAAATAGG
AAGTTCTCACTGAATCCTGGAGGCTGGAACAGCTGGCTCTTTTAGACTCACAAGTCAGACGTTCGATTCCCCTCTGCCAATAGCCAGTTT
TATTGGAGTGAATCACATTTCTTACGCAAATGAAGGGAGCAGACAGTGATTAATGGTTCTGTTGGCCAAGGCTTCTCCCTGTCGGTGAAG
GATCATGTTCAGGCACTCCAAGTGAACCACCCCTCTTGGTTCACCCCTTACTCACTTATCTCATCACAGAGCATAAGGCCCATTTTGTTG
TTCAGGTCAACAGCAAAATGCCTGCACCATGACTGTGGCTTTTAAAATAAAGAAATGTGTTTTTATCGTAATTTATTTCCCCCCAGCCAT
TGCTCACTCTGTCTAGACTTCCTGCCACTTCCAATTCTTCTGTGGCTTTTCCTGCCTTTCCTTTTGACCTCAGTAGTCCTATCCCTGGGA
AGGCCACTTTGCTTCTCTACCTGAGCACCCCTGATTTCTGGAACGCTGCTGAGCCCTGCCTTACTTTTGCCCCTAGGGCTGAAGCTAGAG
GCCTCCCCGTAATAGGCGGTGGAGTTGCTCTGTGAGGATGTTCATGGTAGACACTAAGAGGGCTGGGTGGGAGATGCTTGGCTCTGTGGC
ATCTGTTCAGCGAGGCTTTTCCTATATTGCATGGAGTTAGTCATTGTGATTGTAGCTTTATTTCATAATATATTAAGACTTGCACTGCTA
TTTACTAGCAGTGAGAAGAAACCTCAGGAAAGGATATGAAAAAGCAAGTGGCCAGTGTCTGGGATACTGGGCCTTGGTAAAGCAGAGGAG
GGCACACCCACAGTCCTCTTATTCTCTGTTTTACTGCTTGTTTTGAGGTTCTGGGGTCTGGCAAAGAGGATGCAGTTTGACACCTGCAGC
CCTTTCTCAATCCCACTAATGTCTTACTAATGTGGAACAGTCCATATTAGCTCCAGAGAGTGTCAAACCCAGAGAAATGTGTGCAAAAAT
GATACTCTTTTCTGCATTAGCCCCACCATTGTGTTCACCAATGCTTGGAACACTGCCTGAAGGCACTCATTTTTTAATTTTTATTTTATT
TTTAATTTTTTATATCTTTATGAGACGATCTCACTCTGTCACCAGGTTGGAGTACAGTGGTACAATCACAACTCACCGTAGCCTCAAACT
CCTGGGCTCAAGTGATTCTCCCACCTCAGGCACCCAAATAGCTGGAACTACAGGCATATACCGCCACACCCAGCTAATTTTATTTTTTGA
AAAGACAAGGTTCCCTATGTTGCCCAGCTGGTCTTAAACTCCTGGGCTCCAGCAATTATCCCAGCTTGGGCTCCAAAAGTGCTGGGATTA
CAGGCATGAGTCACCATGCCTGGCCTCATTTTTTAAAACAAATGAATAAATGGACAAATGAGTAAATGAGAAAGTCTCACACCATGAAAG
ATGCTAGTCCAATGAGCTGAATACAGAGGTAATATAAATGTCTTCCAGCTGTTGCTTTTCTGTTCTCAAGCTGCCCCTCCTGGGGTAGGA
GCATAATCTACATCACTGGGCAGTCACAGGACACTCTATAGCAAGGTTGTAGCGTCCTCTCCAGTGGGGGGAGAAAAGGAACTGTGCCTA
CCAAAGGTACTCTCTTGTCAGCAATTTCCATTTCTATACTTTATGGGACACTAGAAACTAAAAGCAACAAATAATCTGATATAAGTCCTT
GTATAGTCATCCTTCAATTCAGTAGCAATATTTTCTGGTCACTACTAACCTGTATTGTATTAAAATGAGACTATTGGAAGGAAATGGTGC
TAAAACTAATAACATCTCTTACCAACCTTTACCCAACTCCTGGGTTGGCAAACAGCTGACCAAACTGCCATCACCTCCCACTTGGAAGTG
TATGGCCGACAGCATGAAATAGCTGAGCCCAGATGTTCCTTCTGCATCCTCCGAATCCCAGGGCTGGGTGTAGGTAGCCGTTGGAGGCCA
TCGCTACAGGGCACCTATCTGTTATCGCTGCTGTCCTCCCAACAGCTGTCTCCAGTTCTAGTTCCTTGGTTTTCAGGCACAGTGGGGGAT
GTTCTGCACCCAGTGGACTTCAAAAGAGTTTTGAAGACTTAATTTTTTGTAAAACAAGTACTTGAGATTTTGGTTTATCCATAATAGAAT
GTATTTCATTAGATTCTCTGATTCTATATAAGAATGTGAAAAGATTGATATATTGTTGTTAGAAATAATGTTATTTCTTTCCAATTTTTT
TTTTTTTTTTTTTTGAGATGGAGTCTCGCTCTGTCACCCAGGCTGGAGTGCAGTGGTGTGATCTCGGCTCACTGCAGCCTCTAACTCCCA
GGTTCAAGCTATTCTCCTGCCTCAGCCTCCCAAGTAGCTGGATTACAGGCATACACCACCACGCCTGGCTATGTTTTGTATTTTTCGTAG
AGATAGGGTTTCACCATGTTGGCCAGGCTGGTCTCAAACTCCTGACCTCAAGTGATCCACCCACTTCAGCTTCCCAAAGCACTGGGATTA
CAGGTGTGAGCCACTGTGCCCGGCAAATTTTTTTACCTTTACAGAAGGTTTTGCTTATTTAATTGTGAGCTCATTTTTCTTTGTTACTTT
TGTCCCCCCAGATTTGGGGGACAAAATAAAATTAATCTTTTAAAATGTGTCAGCCATATGTATGGGGCTTCCATTTGGGGTGAGGAGAAA
GTTCTGGAACTAGATAGTGGTCATGGTTATACAACATCATAAATGCAATTACTGCCACTGAATTGTATGTTTTAAAGTGGTTAAAATGTT
AAGTTTTATGTTTTATTACAATTTTTAAATGTGTCAACCAACTTTATAGTACATAAATTATATCTCAGTAAAGCTGTTAAATAAATAAAT

>79461_79461_1_SCAMP1-ARSB_SCAMP1_chr5_77717784_ENST00000538629_ARSB_chr5_78135249_ENST00000264914_length(amino acids)=363AA_BP=210
MSDFDSNPFADPDLNNPFKDPSVTQVTRNVPPGLDEYNPFSDSRTPPPGGVKMPNVPNTQPAIMKPTEEHPAYTQIAKEHALAQAELLKR
QEELERKAAELDRREREMQNLSQHGRKNNWPPLPSNFPVGPCFYQDFSVDIPVEFQKTVKLMYYLWMFHAVTLFLNIFGCLAWFCVDSAR
AVDFGLSILWFLLFTPCSFVCWYRPLYGAFSEGSPSPRIELLHNIDPNFVDSSPCPRNSMAPAKDDSSLPEYSAFNTSVHAAIRHGNWKL
LTGYPGCGYWFPPPSQYNVSEIPSSDPPTKTLWLFDIDRDPEERHDLSREYPHIVTKLLSRLQFYHKHSVPVYFPAQDPRCDPKATGVWG

--------------------------------------------------------------
>79461_79461_2_SCAMP1-ARSB_SCAMP1_chr5_77717784_ENST00000538629_ARSB_chr5_78135249_ENST00000396151_length(transcript)=1464nt_BP=789nt
GCACCGGGCATGCTCAGTGGCGCGGCCGGCTGGGTGGCCCGCGAGCTGCACCCGGATCTGCTCGGCGGCGGCGACGTGAGCGCGCAGGGG
GGCGGCGGCCTCGCCTCGTCTCTCTCTCTGCGCCTGGGTCGGGTGGGTGACGCCGAGAGCCAGAGAGATGTCGGATTTCGACAGTAACCC
GTTTGCCGACCCGGATCTCAACAATCCCTTCAAGGATCCATCAGTTACACAAGTGACAAGAAATGTTCCACCAGGACTTGATGAATATAA
TCCATTCTCGGATTCTAGAACACCTCCACCAGGCGGTGTGAAGATGCCTAATGTACCCAATACACAACCAGCAATAATGAAACCAACAGA
GGAACATCCAGCTTATACACAGATTGCAAAGGAACATGCATTGGCCCAAGCTGAACTTCTTAAGCGCCAGGAAGAACTAGAAAGAAAAGC
CGCAGAATTAGATCGTCGGGAACGAGAAATGCAAAACCTCAGTCAACATGGTAGAAAAAATAATTGGCCACCTCTTCCTAGCAATTTTCC
TGTCGGACCTTGTTTCTATCAGGATTTTTCTGTAGACATTCCTGTAGAATTCCAAAAGACAGTAAAGCTTATGTACTACTTGTGGATGTT
CCATGCAGTAACACTGTTTCTAAATATCTTCGGATGCTTGGCTTGGTTTTGTGTTGATTCTGCAAGAGCGGTTGATTTTGGATTGAGTAT
CCTGTGGTTCTTGCTTTTTACTCCTTGTTCATTTGTCTGTTGGTACAGACCACTTTATGGAGCTTTCAGTGAAGGAAGCCCATCCCCCAG
AATTGAGCTGCTGCATAATATTGACCCGAACTTCGTGGACTCTTCACCGTACTGGCCTGAGTGCTCGCTGCTGTTGTAGCTACCACCAAC
TTTCTACTGAAGATGATAACCCAGGGCATAAGAAATGACTTCAGACCCAAGGTTCTGAAAGGGCCCCTCAAGGCCTCGGGTGGCTCCTGC
AGAAGTGGCAGAAGAGGCGGGAACTAGGAACCTGGCATCATAGGAAAAGTGCCTTCTCCAAGAAAGAAGGGGCCCCAGGAGGCTGTCTTA
CTTAGATCAACCATAAACTACCACAGATGGGTCATTTCTTATATTATTTCAAAATATCTTTGAAGATGAGAATTCATTTGTGTCCTTCAT
AGACCAAAGTTCTTTGTGTTACCTTTTCCCAAAAGTAAATTCCTTTCCCTTTATTCATTCCTTGTGGAAATAAAATGCAAGCCCTTTATA
CTTGTCTTACAGTAATATGGCACATGTAGCTTACTTTTGAGCATCCCAGTGAATAATGTTTGGAACTTTTCTTATTACCTAATAGCATAT
AGAGAAGAGTGAAGTCAGCTAAAAACAGAAATTTTGAAAAGCCATCTTCAGGAAAATGTAGGCCCAGATGCTTTCCTCCACCTTTTTTGA

>79461_79461_2_SCAMP1-ARSB_SCAMP1_chr5_77717784_ENST00000538629_ARSB_chr5_78135249_ENST00000396151_length(amino acids)=243AA_BP=210
MSDFDSNPFADPDLNNPFKDPSVTQVTRNVPPGLDEYNPFSDSRTPPPGGVKMPNVPNTQPAIMKPTEEHPAYTQIAKEHALAQAELLKR
QEELERKAAELDRREREMQNLSQHGRKNNWPPLPSNFPVGPCFYQDFSVDIPVEFQKTVKLMYYLWMFHAVTLFLNIFGCLAWFCVDSAR

--------------------------------------------------------------
>79461_79461_3_SCAMP1-ARSB_SCAMP1_chr5_77717784_ENST00000538629_ARSB_chr5_78135249_ENST00000565165_length(transcript)=920nt_BP=789nt
GCACCGGGCATGCTCAGTGGCGCGGCCGGCTGGGTGGCCCGCGAGCTGCACCCGGATCTGCTCGGCGGCGGCGACGTGAGCGCGCAGGGG
GGCGGCGGCCTCGCCTCGTCTCTCTCTCTGCGCCTGGGTCGGGTGGGTGACGCCGAGAGCCAGAGAGATGTCGGATTTCGACAGTAACCC
GTTTGCCGACCCGGATCTCAACAATCCCTTCAAGGATCCATCAGTTACACAAGTGACAAGAAATGTTCCACCAGGACTTGATGAATATAA
TCCATTCTCGGATTCTAGAACACCTCCACCAGGCGGTGTGAAGATGCCTAATGTACCCAATACACAACCAGCAATAATGAAACCAACAGA
GGAACATCCAGCTTATACACAGATTGCAAAGGAACATGCATTGGCCCAAGCTGAACTTCTTAAGCGCCAGGAAGAACTAGAAAGAAAAGC
CGCAGAATTAGATCGTCGGGAACGAGAAATGCAAAACCTCAGTCAACATGGTAGAAAAAATAATTGGCCACCTCTTCCTAGCAATTTTCC
TGTCGGACCTTGTTTCTATCAGGATTTTTCTGTAGACATTCCTGTAGAATTCCAAAAGACAGTAAAGCTTATGTACTACTTGTGGATGTT
CCATGCAGTAACACTGTTTCTAAATATCTTCGGATGCTTGGCTTGGTTTTGTGTTGATTCTGCAAGAGCGGTTGATTTTGGATTGAGTAT
CCTGTGGTTCTTGCTTTTTACTCCTTGTTCATTTGTCTGTTGGTACAGACCACTTTATGGAGCTTTCAGTGAAGGAAGCCCATCCCCCAG
AATTGAGCTGCTGCATAATATTGACCCGAACTTCGTGGACTCTTCACCGTACTGGCCTGAGTGCTCGCTGCTGTTGTAGCTACCACCAAC

>79461_79461_3_SCAMP1-ARSB_SCAMP1_chr5_77717784_ENST00000538629_ARSB_chr5_78135249_ENST00000565165_length(amino acids)=243AA_BP=210
MSDFDSNPFADPDLNNPFKDPSVTQVTRNVPPGLDEYNPFSDSRTPPPGGVKMPNVPNTQPAIMKPTEEHPAYTQIAKEHALAQAELLKR
QEELERKAAELDRREREMQNLSQHGRKNNWPPLPSNFPVGPCFYQDFSVDIPVEFQKTVKLMYYLWMFHAVTLFLNIFGCLAWFCVDSAR

--------------------------------------------------------------

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Fusion Gene PPI Analysis for SCAMP1-ARSB


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for SCAMP1-ARSB


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for SCAMP1-ARSB


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource