FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:SCAPER-TSPAN3 (FusionGDB2 ID:79509)

Fusion Gene Summary for SCAPER-TSPAN3

check button Fusion gene summary
Fusion gene informationFusion gene name: SCAPER-TSPAN3
Fusion gene ID: 79509
HgeneTgene
Gene symbol

SCAPER

TSPAN3

Gene ID

49855

10099

Gene nameS-phase cyclin A associated protein in the ERtetraspanin 3
SynonymsIDDRP|MSTP063|ZNF291|Zfp291TM4-A|TM4SF8|TSPAN-3
Cytomap

15q24.3

15q24.3

Type of geneprotein-codingprotein-coding
DescriptionS phase cyclin A-associated protein in the endoplasmic reticulumzinc finger protein 291tetraspanin-3tetraspan 3tetraspan TM4SFtetraspanin TM4-Atransmembrane 4 superfamily member 8
Modification date2020031320200322
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000324767, ENST00000563290, 
ENST00000538941, ENST00000562890, 
ENST00000558394, ENST00000558745, 
ENST00000561277, ENST00000424443, 
ENST00000559494, ENST00000267970, 
ENST00000346495, 
Fusion gene scores* DoF score17 X 15 X 8=204012 X 7 X 9=756
# samples 1713
** MAII scorelog2(17/2040*10)=-3.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(13/756*10)=-2.53987461119262
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SCAPER [Title/Abstract] AND TSPAN3 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointSCAPER(77134075)-TSPAN3(77348597), # samples:3
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across SCAPER (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across TSPAN3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SKCMTCGA-EE-A29D-06ASCAPERchr15

77134075

-TSPAN3chr15

77348597

-


Top

Fusion Gene ORF analysis for SCAPER-TSPAN3

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000324767ENST00000558394SCAPERchr15

77134075

-TSPAN3chr15

77348597

-
5CDS-5UTRENST00000324767ENST00000558745SCAPERchr15

77134075

-TSPAN3chr15

77348597

-
5CDS-5UTRENST00000324767ENST00000561277SCAPERchr15

77134075

-TSPAN3chr15

77348597

-
5CDS-5UTRENST00000563290ENST00000558394SCAPERchr15

77134075

-TSPAN3chr15

77348597

-
5CDS-5UTRENST00000563290ENST00000558745SCAPERchr15

77134075

-TSPAN3chr15

77348597

-
5CDS-5UTRENST00000563290ENST00000561277SCAPERchr15

77134075

-TSPAN3chr15

77348597

-
5CDS-intronENST00000324767ENST00000424443SCAPERchr15

77134075

-TSPAN3chr15

77348597

-
5CDS-intronENST00000324767ENST00000559494SCAPERchr15

77134075

-TSPAN3chr15

77348597

-
5CDS-intronENST00000563290ENST00000424443SCAPERchr15

77134075

-TSPAN3chr15

77348597

-
5CDS-intronENST00000563290ENST00000559494SCAPERchr15

77134075

-TSPAN3chr15

77348597

-
5UTR-3CDSENST00000538941ENST00000267970SCAPERchr15

77134075

-TSPAN3chr15

77348597

-
5UTR-3CDSENST00000538941ENST00000346495SCAPERchr15

77134075

-TSPAN3chr15

77348597

-
5UTR-5UTRENST00000538941ENST00000558394SCAPERchr15

77134075

-TSPAN3chr15

77348597

-
5UTR-5UTRENST00000538941ENST00000558745SCAPERchr15

77134075

-TSPAN3chr15

77348597

-
5UTR-5UTRENST00000538941ENST00000561277SCAPERchr15

77134075

-TSPAN3chr15

77348597

-
5UTR-intronENST00000538941ENST00000424443SCAPERchr15

77134075

-TSPAN3chr15

77348597

-
5UTR-intronENST00000538941ENST00000559494SCAPERchr15

77134075

-TSPAN3chr15

77348597

-
Frame-shiftENST00000563290ENST00000267970SCAPERchr15

77134075

-TSPAN3chr15

77348597

-
Frame-shiftENST00000563290ENST00000346495SCAPERchr15

77134075

-TSPAN3chr15

77348597

-
In-frameENST00000324767ENST00000267970SCAPERchr15

77134075

-TSPAN3chr15

77348597

-
In-frameENST00000324767ENST00000346495SCAPERchr15

77134075

-TSPAN3chr15

77348597

-
intron-3CDSENST00000562890ENST00000267970SCAPERchr15

77134075

-TSPAN3chr15

77348597

-
intron-3CDSENST00000562890ENST00000346495SCAPERchr15

77134075

-TSPAN3chr15

77348597

-
intron-5UTRENST00000562890ENST00000558394SCAPERchr15

77134075

-TSPAN3chr15

77348597

-
intron-5UTRENST00000562890ENST00000558745SCAPERchr15

77134075

-TSPAN3chr15

77348597

-
intron-5UTRENST00000562890ENST00000561277SCAPERchr15

77134075

-TSPAN3chr15

77348597

-
intron-intronENST00000562890ENST00000424443SCAPERchr15

77134075

-TSPAN3chr15

77348597

-
intron-intronENST00000562890ENST00000559494SCAPERchr15

77134075

-TSPAN3chr15

77348597

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000324767SCAPERchr1577134075-ENST00000267970TSPAN3chr1577348597-3969452591150363
ENST00000324767SCAPERchr1577134075-ENST00000346495TSPAN3chr1577348597-1881452591075338

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000324767ENST00000267970SCAPERchr1577134075-TSPAN3chr1577348597-0.0001429240.99985707
ENST00000324767ENST00000346495SCAPERchr1577134075-TSPAN3chr1577348597-0.0001767750.9998233

Top

Fusion Genomic Features for SCAPER-TSPAN3


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for SCAPER-TSPAN3


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr15:77134075/chr15:77348597)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneTSPAN3chr15:77134075chr15:77348597ENST0000026797007107_21221254.0Topological domainExtracellular
TgeneTSPAN3chr15:77134075chr15:77348597ENST0000026797007234_25321254.0Topological domainCytoplasmic
TgeneTSPAN3chr15:77134075chr15:77348597ENST000002679700733_5021254.0Topological domainExtracellular
TgeneTSPAN3chr15:77134075chr15:77348597ENST000002679700772_8521254.0Topological domainCytoplasmic
TgeneTSPAN3chr15:77134075chr15:77348597ENST0000034649506107_21221229.0Topological domainExtracellular
TgeneTSPAN3chr15:77134075chr15:77348597ENST0000034649506234_25321229.0Topological domainCytoplasmic
TgeneTSPAN3chr15:77134075chr15:77348597ENST000003464950633_5021229.0Topological domainExtracellular
TgeneTSPAN3chr15:77134075chr15:77348597ENST000003464950672_8521229.0Topological domainCytoplasmic
TgeneTSPAN3chr15:77134075chr15:77348597ENST0000042444306107_2120190.0Topological domainExtracellular
TgeneTSPAN3chr15:77134075chr15:77348597ENST00000424443061_110190.0Topological domainCytoplasmic
TgeneTSPAN3chr15:77134075chr15:77348597ENST0000042444306234_2530190.0Topological domainCytoplasmic
TgeneTSPAN3chr15:77134075chr15:77348597ENST000004244430633_500190.0Topological domainExtracellular
TgeneTSPAN3chr15:77134075chr15:77348597ENST000004244430672_850190.0Topological domainCytoplasmic
TgeneTSPAN3chr15:77134075chr15:77348597ENST0000026797007213_23321254.0TransmembraneHelical
TgeneTSPAN3chr15:77134075chr15:77348597ENST000002679700751_7121254.0TransmembraneHelical
TgeneTSPAN3chr15:77134075chr15:77348597ENST000002679700786_10621254.0TransmembraneHelical
TgeneTSPAN3chr15:77134075chr15:77348597ENST0000034649506213_23321229.0TransmembraneHelical
TgeneTSPAN3chr15:77134075chr15:77348597ENST000003464950651_7121229.0TransmembraneHelical
TgeneTSPAN3chr15:77134075chr15:77348597ENST000003464950686_10621229.0TransmembraneHelical
TgeneTSPAN3chr15:77134075chr15:77348597ENST000004244430612_320190.0TransmembraneHelical
TgeneTSPAN3chr15:77134075chr15:77348597ENST0000042444306213_2330190.0TransmembraneHelical
TgeneTSPAN3chr15:77134075chr15:77348597ENST000004244430651_710190.0TransmembraneHelical
TgeneTSPAN3chr15:77134075chr15:77348597ENST000004244430686_1060190.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSCAPERchr15:77134075chr15:77348597ENST00000324767-431395_7701311401.0Compositional biasNote=Glu-rich
HgeneSCAPERchr15:77134075chr15:77348597ENST00000538941-432395_77001155.0Compositional biasNote=Glu-rich
HgeneSCAPERchr15:77134075chr15:77348597ENST00000563290-532395_7701311401.0Compositional biasNote=Glu-rich
HgeneSCAPERchr15:77134075chr15:77348597ENST00000324767-431792_8161311401.0Zinc fingerNote=C2H2-type
HgeneSCAPERchr15:77134075chr15:77348597ENST00000538941-432792_81601155.0Zinc fingerNote=C2H2-type
HgeneSCAPERchr15:77134075chr15:77348597ENST00000563290-532792_8161311401.0Zinc fingerNote=C2H2-type
TgeneTSPAN3chr15:77134075chr15:77348597ENST00000267970071_1121254.0Topological domainCytoplasmic
TgeneTSPAN3chr15:77134075chr15:77348597ENST00000346495061_1121229.0Topological domainCytoplasmic
TgeneTSPAN3chr15:77134075chr15:77348597ENST000002679700712_3221254.0TransmembraneHelical
TgeneTSPAN3chr15:77134075chr15:77348597ENST000003464950612_3221229.0TransmembraneHelical


Top

Fusion Gene Sequence for SCAPER-TSPAN3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>79509_79509_1_SCAPER-TSPAN3_SCAPER_chr15_77134075_ENST00000324767_TSPAN3_chr15_77348597_ENST00000267970_length(transcript)=3969nt_BP=452nt
GAGTCATACTCCATGGGTTTATGTGATAAATGATCTTGGCATAGAAGAGAATTTAAAGAATGATGGCTTCATTCCAGCGCTCCAATAGTC
ATGACAAAGTAAGGAGAATAGTTGCAGAGGAGGGTCGTACAGCAAGAAACCTAATAGCTTGGAGTGTTCCACTAGAAAGCAAAGATGATG
ATGGAAAACCTAAATGTCAAACTGGTGGAAAATCTAAGAGGACCATTCAAGGCACTCATAAAACTACTAAACAGAGTACTGCAGTGGACT
GTAAAATAACATCGTCTACGACTGGAGATAAACACTTTGATAAAAGTCCCACTAAAACAAGGCACCCTCGGAAAATTGATCTAAGAGCTC
GATACTGGGCATTTCTTTTTGATAATCTTCGCCGAGCAGTAGATGAAATCTATGTAACTTGCGAATCAGATCAGAGTGTGGTCGAATGTA
AGGGGGCAGCTGGCATTTTATGCTATGTGGGAGCCTATGTCTTCATCACTTATGATGACTATGACCACTTCTTTGAAGATGTGTACACGC
TCATCCCTGCTGTAGTGATCATAGCTGTAGGAGCCCTGCTTTTCATCATTGGGCTAATTGGCTGCTGTGCCACAATCCGGGAAAGTCGCT
GTGGACTTGCCACGTTTGTCATCATCCTGCTCTTGGTTTTTGTCACAGAAGTTGTTGTAGTGGTTTTGGGATATGTTTACAGAGCAAAGG
TGGAAAATGAGGTTGATCGCAGCATTCAGAAAGTGTATAAGACCTACAATGGAACCAACCCTGATGCTGCTAGCCGGGCTATTGATTATG
TACAGAGACAGCTGCATTGTTGTGGAATTCACAACTACTCAGACTGGGAAAATACAGATTGGTTCAAAGAAACCAAAAACCAGAGTGTCC
CTCTTAGCTGCTGCAGAGAGACTGCCAGCAATTGTAATGGCAGCCTGGCCCACCCTTCCGACCTCTATGCTGAGGGGTGTGAGGCTCTAG
TAGTGAAGAAGCTACAAGAAATCATGATGCATGTGATCTGGGCCGCACTGGCATTTGCAGCTATTCAGCTGCTGGGCATGCTGTGTGCTT
GCATCGTGTTGTGCAGAAGGAGTAGAGATCCTGCTTACGAGCTCCTCATCACTGGCGGAACCTATGCATAGTTGACAACTCAAGCCTGAG
CTTTTTGGTCTTGTTCTGATTTGGAAGGTGAATTGAGCAGGTCTGCTGCTGTTGGCCTCTGGAGTTCATTTAGTTAAAGCACATGTACAC
TGGTGTTGGACAGAGCAGCTTGGCTTTTCATGTGCCCACCTACTTACCTACTACCTGCGACTTTCTTTTTCCTTGTTCTAGCTGACTCTT
CATGCCCCTAAGATTTTAAGTACGATGGTGAACGTTCTAATTTCAGAACCAATTGCGAGTCATGTAGTGTGGTAGAATTAAAGGAGGACA
CGAGCCTGCTTCTGTTACCTCCAAGTGGTAACAGGACTGATGCCGAAATGTCACCAGGTCCTTTCAGTCTTCACAGTGGAGAACTCTTGG
CCAAAGGTTTTTGCGGGGAGGAGGAGGAAACCAGCTTTCTGGTTAAGGTTAACACCAGATGGTGCCCCTCATTGGTGTCCTTTTAAAAAA
TATTTACTGTAGTCCAATAAGATAGCAGCTGTACAAAATGACTAAAATAGATTGTAGGATCATATGGCGTATATCTTGGTTCATCTTCAA
AATCAGAGACTGAGCTTTGAAACTAGTGGTTTTTAATCAAAGTTGGCTTTATAGGAGGAGTATAATGTATGCACTACTGTTTTAAAAGAA
TTAGTGTGAGTGTGTTTTTGTATGAATGAGCCCATTCATGGTAAGTCTTAAGCTTGTTGGAAATAATGTACCCATGTAGACTAGCAAAAT
AGTATGTAGATGTGATCTCAGTTGTAAATAGAAAAATCTAATTCAATAAACTCTGTATCAGCCCCCAACATATTATTTTTCATTATTTGG
GGGATATTTCAGTTCCAGAGCAGCAGTATCATGTTTTCTTTGTTGGTGCTGTCTATAGTTCATCATGGTTTACGTGTGTTTTCGTTATAG
CTGTTGCCAGATTCTAAAGGGCTTGATATTCAAAAAACCACAGATGCTTTCAGTCCAGTATATCCTAGAAATATAGAGCTCTACTTTGTG
CAATGCACTGGGGATACAGTGGCGATACTGTCCTTGTCTTCAAGGAGTTCGGAGTCCTAGTATAGGAGACATACATAGGAGAAGATAATT
TTCACACTGCAGTGGTTGTAGTAATAGAATGGGAGTCCAAAGGGGAGTTCCGGAGAGGTCAGGGGTGACTTCCTGGAGGAGATGCCCAAG
CTTGGAGGCTGGATAGGCTTTGTTGAAAGATGGTACACAAGAGTGTGAAACAAAATTGTGTGTGCAGGGAGCTTAAAATACAAGGCTGGG
GAAAGAAGTTGGAGAAGCAGGAAAGCCCAGGCCCTCTAGTGTCTTACGGAACATCCTGTGGAGGTGAGAGCTGACTTGTAGGTGGAAGCA
GCTCTTTGGAGGTTTGATTTGGAAGGTGAACTGAGAAGAAGGTGGTGATGCAAGCCGGCCGTGCTGAAGCCAGGATGAATTGGTGTGACT
GGGCTTCAGTTAGGCTGGCATAGCAGTTGAGAGAGCTTAGCAGTGGGCAGCAGGGCACTGTTGGGGGCGGTGGTGAGCGGTGGATTCTGG
CTGTTTGGAGGCAGGACAGTGGTGGAATTCGATCATTGATTGGACGTGGGACAGAGAAGGGAGAAGAGAAGACTCATCTAGGATGAGTCC
CAGGTTTCTGGCTCAGTCAACTGGGGAAACAAAGTCACAGAGCTAGGGAGTAGTTAGAGAACACATCTGGGGGTGTGACTCATGGTCAGT
TTTGGGCTCGTCAGTTTTGAGATGCCCAAATATCATGCAGATCTGTCCCACCTGAAAATGGAGAAGACACGGGAAAGGAGAGGAGTAAAA
ACTAACTCCTTTTCACAAAGTGGAAGTTACCAGAATGTGATTTCAGAGGCCCCGGGGGATTTATCATGTGACTACTGACCCATCCCACCT
CTTGCCCCTGCCTGTTGCACAGTGGGCAAGAATGTTTGTGACCTTTCACTACCACCACCTCCCCCGAGCATGGTCCCCCCAGTTTTCAAT
ATGAACCATCCTGTGGGTACCCTGTCACAGGCTGGCCCTGAGGTGAGCAATATTTGGACTGTGATGTTGGTTGTTCTCCACTCTTTCTAC
AGGACAGAACAGGGCCTCTAGAGTGGGAAATGGCTTTGGGAAATATGCCAAGCAGTAGCCTTGTTCTTCAACTTGCCCAAGAGGATAATT
CTCCACACCCTTCCTGTACTCAGTCCTCAGTTTGCCTGGTGAGAGAGCAGCCTCCTCCCGTGTGCTCTGCCAGCTGGACCCAGACTGGCC
ATATTACCAGTGAGACCAAAAAGATGGAGGTGGGGAGGTAGCTCTGAGGTCTGGGAAACCATTCCAGCTCCTGCCAGTTTTAACTTGTGT
TTAATTCCTGGCACAGTTGTCCTGGAAATGCCTTTTTCTCTTGCCTGGGAACCACTAGAAGGGGATGTTGTCTGTGTTGGCCAGGGCCAT
GCAAATTCAACATCTTGTTTCTGCCCTTCCCCCGTGTAGCTGAGGCTAGGTGTTGGCATTACCCAGTGCTTGTTCTTCAGAGAGCAAAAG
CACTGCTCGTCATGTCTGAAATTTAGTGAGTGAGCTCACCCACTAGGCTGGTGTTTCCTGCCCGTGGCTGCACATTGGAAGCACCGGGGC
ACTTTGAGAACTACAGATGCCTGGGTCCCAGAGCATCTAAGGTGCTCTAGGGTGTGTCCAGGACACAGCCCTGGTTGAGGACCACTGCTA
TATTGTATGGCCTCTTTTAAAAAAGTTAATTTTACTTGGAAATGATTTCAAAGCTACAGAAAAGTTGCAAGAATAAAAACTGTACAAATG

>79509_79509_1_SCAPER-TSPAN3_SCAPER_chr15_77134075_ENST00000324767_TSPAN3_chr15_77348597_ENST00000267970_length(amino acids)=363AA_BP=131
MMASFQRSNSHDKVRRIVAEEGRTARNLIAWSVPLESKDDDGKPKCQTGGKSKRTIQGTHKTTKQSTAVDCKITSSTTGDKHFDKSPTKT
RHPRKIDLRARYWAFLFDNLRRAVDEIYVTCESDQSVVECKGAAGILCYVGAYVFITYDDYDHFFEDVYTLIPAVVIIAVGALLFIIGLI
GCCATIRESRCGLATFVIILLLVFVTEVVVVVLGYVYRAKVENEVDRSIQKVYKTYNGTNPDAASRAIDYVQRQLHCCGIHNYSDWENTD
WFKETKNQSVPLSCCRETASNCNGSLAHPSDLYAEGCEALVVKKLQEIMMHVIWAALAFAAIQLLGMLCACIVLCRRSRDPAYELLITGG

--------------------------------------------------------------
>79509_79509_2_SCAPER-TSPAN3_SCAPER_chr15_77134075_ENST00000324767_TSPAN3_chr15_77348597_ENST00000346495_length(transcript)=1881nt_BP=452nt
GAGTCATACTCCATGGGTTTATGTGATAAATGATCTTGGCATAGAAGAGAATTTAAAGAATGATGGCTTCATTCCAGCGCTCCAATAGTC
ATGACAAAGTAAGGAGAATAGTTGCAGAGGAGGGTCGTACAGCAAGAAACCTAATAGCTTGGAGTGTTCCACTAGAAAGCAAAGATGATG
ATGGAAAACCTAAATGTCAAACTGGTGGAAAATCTAAGAGGACCATTCAAGGCACTCATAAAACTACTAAACAGAGTACTGCAGTGGACT
GTAAAATAACATCGTCTACGACTGGAGATAAACACTTTGATAAAAGTCCCACTAAAACAAGGCACCCTCGGAAAATTGATCTAAGAGCTC
GATACTGGGCATTTCTTTTTGATAATCTTCGCCGAGCAGTAGATGAAATCTATGTAACTTGCGAATCAGATCAGAGTGTGGTCGAATGTA
AGGGGGCAGCTGGCATTTTATGCTATGTGGGAGCCTATGTCTTCATCACTTATGATGACTATGACCACTTCTTTGAAGATGTGTACACGC
TCATCCCTGCTGTAGTGATCATAGCTGTAGGAGCCCTGCTTTTCATCATTGGGCTAATTGGCTGCTGTGCCACAATCCGGGAAAGTCGCT
GTGGACTTGCCACGGTGGAAAATGAGGTTGATCGCAGCATTCAGAAAGTGTATAAGACCTACAATGGAACCAACCCTGATGCTGCTAGCC
GGGCTATTGATTATGTACAGAGACAGCTGCATTGTTGTGGAATTCACAACTACTCAGACTGGGAAAATACAGATTGGTTCAAAGAAACCA
AAAACCAGAGTGTCCCTCTTAGCTGCTGCAGAGAGACTGCCAGCAATTGTAATGGCAGCCTGGCCCACCCTTCCGACCTCTATGCTGAGG
GGTGTGAGGCTCTAGTAGTGAAGAAGCTACAAGAAATCATGATGCATGTGATCTGGGCCGCACTGGCATTTGCAGCTATTCAGCTGCTGG
GCATGCTGTGTGCTTGCATCGTGTTGTGCAGAAGGAGTAGAGATCCTGCTTACGAGCTCCTCATCACTGGCGGAACCTATGCATAGTTGA
CAACTCAAGCCTGAGCTTTTTGGTCTTGTTCTGATTTGGAAGGTGAATTGAGCAGGTCTGCTGCTGTTGGCCTCTGGAGTTCATTTAGTT
AAAGCACATGTACACTGGTGTTGGACAGAGCAGCTTGGCTTTTCATGTGCCCACCTACTTACCTACTACCTGCGACTTTCTTTTTCCTTG
TTCTAGCTGACTCTTCATGCCCCTAAGATTTTAAGTACGATGGTGAACGTTCTAATTTCAGAACCAATTGCGAGTCATGTAGTGTGGTAG
AATTAAAGGAGGACACGAGCCTGCTTCTGTTACCTCCAAGTGGTAACAGGACTGATGCCGAAATGTCACCAGGTCCTTTCAGTCTTCACA
GTGGAGAACTCTTGGCCAAAGGTTTTTGCGGGGAGGAGGAGGAAACCAGCTTTCTGGTTAAGGTTAACACCAGATGGTGCCCCTCATTGG
TGTCCTTTTAAAAAATATTTACTGTAGTCCAATAAGATAGCAGCTGTACAAAATGACTAAAATAGATTGTAGGATCATATGGCGTATATC
TTGGTTCATCTTCAAAATCAGAGACTGAGCTTTGAAACTAGTGGTTTTTAATCAAAGTTGGCTTTATAGGAGGAGTATAATGTATGCACT
ACTGTTTTAAAAGAATTAGTGTGAGTGTGTTTTTGTATGAATGAGCCCATTCATGGTAAGTCTTAAGCTTGTTGGAAATAATGTACCCAT

>79509_79509_2_SCAPER-TSPAN3_SCAPER_chr15_77134075_ENST00000324767_TSPAN3_chr15_77348597_ENST00000346495_length(amino acids)=338AA_BP=131
MMASFQRSNSHDKVRRIVAEEGRTARNLIAWSVPLESKDDDGKPKCQTGGKSKRTIQGTHKTTKQSTAVDCKITSSTTGDKHFDKSPTKT
RHPRKIDLRARYWAFLFDNLRRAVDEIYVTCESDQSVVECKGAAGILCYVGAYVFITYDDYDHFFEDVYTLIPAVVIIAVGALLFIIGLI
GCCATIRESRCGLATVENEVDRSIQKVYKTYNGTNPDAASRAIDYVQRQLHCCGIHNYSDWENTDWFKETKNQSVPLSCCRETASNCNGS

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for SCAPER-TSPAN3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for SCAPER-TSPAN3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for SCAPER-TSPAN3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource