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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:SCD5-SEC31A (FusionGDB2 ID:79579)

Fusion Gene Summary for SCD5-SEC31A

check button Fusion gene summary
Fusion gene informationFusion gene name: SCD5-SEC31A
Fusion gene ID: 79579
HgeneTgene
Gene symbol

SCD5

SEC31A

Gene ID

79966

22872

Gene namestearoyl-CoA desaturase 5SEC31 homolog A, COPII coat complex component
SynonymsACOD4|FADS4|HSCD5|SCD2|SCD4ABP125|ABP130|HSPC275|HSPC334|NEDSOSB|SEC31L1
Cytomap

4q21.22

4q21.22

Type of geneprotein-codingprotein-coding
Descriptionstearoyl-CoA desaturase 5acyl-CoA-desaturase 4stearoyl-CoA 9-desaturasestearoyl-CoA desaturase 2stearoyl-CoA desaturase 4protein transport protein Sec31ASEC31 homolog A, COPII coating complex componentSEC31-like protein 1SEC31-related protein Aweb1-like proteinyeast Sec31p homolog
Modification date2020031320200313
UniProtAcc.

O94979

Ensembl transtripts involved in fusion geneENST00000273908, ENST00000282709, 
ENST00000319540, 		ENST00000436790, 
ENST00000264405, ENST00000311785, 
ENST00000326950, ENST00000348405, 
ENST00000355196, ENST00000395310, 
ENST00000432794, ENST00000443462, 
ENST00000448323, ENST00000500777, 
ENST00000505472, ENST00000505984, 
ENST00000508479, ENST00000508502, 
ENST00000509142, ENST00000513858, 
Fusion gene scores* DoF score11 X 9 X 7=69327 X 19 X 11=5643
# samples 1328
** MAII scorelog2(13/693*10)=-2.41434372910876
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(28/5643*10)=-4.33296361729939
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SCD5 [Title/Abstract] AND SEC31A [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointSCD5(83719459)-SEC31A(83765662), # samples:2
SEC31A(83812241)-SCD5(83557976), # samples:2
Anticipated loss of major functional domain due to fusion event.SEC31A-SCD5 seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
SEC31A-SCD5 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneSCD5

GO:0006636

unsaturated fatty acid biosynthetic process

15907797

TgeneSEC31A

GO:0051592

response to calcium ion

17196169

TgeneSEC31A

GO:0090110

cargo loading into COPII-coated vesicle

17499046|18843296


check buttonFusion gene breakpoints across SCD5 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across SEC31A (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4ACCTCGA-OR-A5J7-01ASCD5chr4

83719459

-SEC31Achr4

83765662

-


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Fusion Gene ORF analysis for SCD5-SEC31A

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000273908ENST00000436790SCD5chr4

83719459

-SEC31Achr4

83765662

-
5CDS-intronENST00000282709ENST00000436790SCD5chr4

83719459

-SEC31Achr4

83765662

-
5CDS-intronENST00000319540ENST00000436790SCD5chr4

83719459

-SEC31Achr4

83765662

-
In-frameENST00000273908ENST00000264405SCD5chr4

83719459

-SEC31Achr4

83765662

-
In-frameENST00000273908ENST00000311785SCD5chr4

83719459

-SEC31Achr4

83765662

-
In-frameENST00000273908ENST00000326950SCD5chr4

83719459

-SEC31Achr4

83765662

-
In-frameENST00000273908ENST00000348405SCD5chr4

83719459

-SEC31Achr4

83765662

-
In-frameENST00000273908ENST00000355196SCD5chr4

83719459

-SEC31Achr4

83765662

-
In-frameENST00000273908ENST00000395310SCD5chr4

83719459

-SEC31Achr4

83765662

-
In-frameENST00000273908ENST00000432794SCD5chr4

83719459

-SEC31Achr4

83765662

-
In-frameENST00000273908ENST00000443462SCD5chr4

83719459

-SEC31Achr4

83765662

-
In-frameENST00000273908ENST00000448323SCD5chr4

83719459

-SEC31Achr4

83765662

-
In-frameENST00000273908ENST00000500777SCD5chr4

83719459

-SEC31Achr4

83765662

-
In-frameENST00000273908ENST00000505472SCD5chr4

83719459

-SEC31Achr4

83765662

-
In-frameENST00000273908ENST00000505984SCD5chr4

83719459

-SEC31Achr4

83765662

-
In-frameENST00000273908ENST00000508479SCD5chr4

83719459

-SEC31Achr4

83765662

-
In-frameENST00000273908ENST00000508502SCD5chr4

83719459

-SEC31Achr4

83765662

-
In-frameENST00000273908ENST00000509142SCD5chr4

83719459

-SEC31Achr4

83765662

-
In-frameENST00000273908ENST00000513858SCD5chr4

83719459

-SEC31Achr4

83765662

-
In-frameENST00000282709ENST00000264405SCD5chr4

83719459

-SEC31Achr4

83765662

-
In-frameENST00000282709ENST00000311785SCD5chr4

83719459

-SEC31Achr4

83765662

-
In-frameENST00000282709ENST00000326950SCD5chr4

83719459

-SEC31Achr4

83765662

-
In-frameENST00000282709ENST00000348405SCD5chr4

83719459

-SEC31Achr4

83765662

-
In-frameENST00000282709ENST00000355196SCD5chr4

83719459

-SEC31Achr4

83765662

-
In-frameENST00000282709ENST00000395310SCD5chr4

83719459

-SEC31Achr4

83765662

-
In-frameENST00000282709ENST00000432794SCD5chr4

83719459

-SEC31Achr4

83765662

-
In-frameENST00000282709ENST00000443462SCD5chr4

83719459

-SEC31Achr4

83765662

-
In-frameENST00000282709ENST00000448323SCD5chr4

83719459

-SEC31Achr4

83765662

-
In-frameENST00000282709ENST00000500777SCD5chr4

83719459

-SEC31Achr4

83765662

-
In-frameENST00000282709ENST00000505472SCD5chr4

83719459

-SEC31Achr4

83765662

-
In-frameENST00000282709ENST00000505984SCD5chr4

83719459

-SEC31Achr4

83765662

-
In-frameENST00000282709ENST00000508479SCD5chr4

83719459

-SEC31Achr4

83765662

-
In-frameENST00000282709ENST00000508502SCD5chr4

83719459

-SEC31Achr4

83765662

-
In-frameENST00000282709ENST00000509142SCD5chr4

83719459

-SEC31Achr4

83765662

-
In-frameENST00000282709ENST00000513858SCD5chr4

83719459

-SEC31Achr4

83765662

-
In-frameENST00000319540ENST00000264405SCD5chr4

83719459

-SEC31Achr4

83765662

-
In-frameENST00000319540ENST00000311785SCD5chr4

83719459

-SEC31Achr4

83765662

-
In-frameENST00000319540ENST00000326950SCD5chr4

83719459

-SEC31Achr4

83765662

-
In-frameENST00000319540ENST00000348405SCD5chr4

83719459

-SEC31Achr4

83765662

-
In-frameENST00000319540ENST00000355196SCD5chr4

83719459

-SEC31Achr4

83765662

-
In-frameENST00000319540ENST00000395310SCD5chr4

83719459

-SEC31Achr4

83765662

-
In-frameENST00000319540ENST00000432794SCD5chr4

83719459

-SEC31Achr4

83765662

-
In-frameENST00000319540ENST00000443462SCD5chr4

83719459

-SEC31Achr4

83765662

-
In-frameENST00000319540ENST00000448323SCD5chr4

83719459

-SEC31Achr4

83765662

-
In-frameENST00000319540ENST00000500777SCD5chr4

83719459

-SEC31Achr4

83765662

-
In-frameENST00000319540ENST00000505472SCD5chr4

83719459

-SEC31Achr4

83765662

-
In-frameENST00000319540ENST00000505984SCD5chr4

83719459

-SEC31Achr4

83765662

-
In-frameENST00000319540ENST00000508479SCD5chr4

83719459

-SEC31Achr4

83765662

-
In-frameENST00000319540ENST00000508502SCD5chr4

83719459

-SEC31Achr4

83765662

-
In-frameENST00000319540ENST00000509142SCD5chr4

83719459

-SEC31Achr4

83765662

-
In-frameENST00000319540ENST00000513858SCD5chr4

83719459

-SEC31Achr4

83765662

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for SCD5-SEC31A


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for SCD5-SEC31A


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr4:83719459/chr4:83765662)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.SEC31A

O94979

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER) (PubMed:10788476). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules (By similarity). {ECO:0000250|UniProtKB:Q9Z2Q1, ECO:0000269|PubMed:10788476}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSCD5chr4:83719459chr4:83765662ENST00000273908-141_4977257.0Topological domainCytoplasmic
HgeneSCD5chr4:83719459chr4:83765662ENST00000273908-1471_7277257.0Topological domainLumenal
HgeneSCD5chr4:83719459chr4:83765662ENST00000319540-151_4977331.0Topological domainCytoplasmic
HgeneSCD5chr4:83719459chr4:83765662ENST00000319540-1571_7277331.0Topological domainLumenal
HgeneSCD5chr4:83719459chr4:83765662ENST00000273908-1450_7077257.0TransmembraneHelical
HgeneSCD5chr4:83719459chr4:83765662ENST00000319540-1550_7077331.0TransmembraneHelical
TgeneSEC31Achr4:83719459chr4:83765662ENST000003269501725800_10917951182.0Compositional biasNote=Pro-rich
TgeneSEC31Achr4:83719459chr4:83765662ENST000003484051725800_10917951182.0Compositional biasNote=Pro-rich
TgeneSEC31Achr4:83719459chr4:83765662ENST000005007771623800_10917951068.0Compositional biasNote=Pro-rich
TgeneSEC31Achr4:83719459chr4:83765662ENST000005138581724800_10917951068.0Compositional biasNote=Pro-rich
TgeneSEC31Achr4:83719459chr4:83765662ENST000003117851926842_8488341107.0MotifNote=ALG-2-binding site motif-2 (ABS-2)%2C
TgeneSEC31Achr4:83719459chr4:83765662ENST000003269501725842_8487951182.0MotifNote=ALG-2-binding site motif-2 (ABS-2)%2C
TgeneSEC31Achr4:83719459chr4:83765662ENST000003484051725842_8487951182.0MotifNote=ALG-2-binding site motif-2 (ABS-2)%2C
TgeneSEC31Achr4:83719459chr4:83765662ENST000003551962129842_8488341221.0MotifNote=ALG-2-binding site motif-2 (ABS-2)%2C
TgeneSEC31Achr4:83719459chr4:83765662ENST000003953101927842_8488341221.0MotifNote=ALG-2-binding site motif-2 (ABS-2)%2C
TgeneSEC31Achr4:83719459chr4:83765662ENST000004327941928842_8488341234.0MotifNote=ALG-2-binding site motif-2 (ABS-2)%2C
TgeneSEC31Achr4:83719459chr4:83765662ENST000004434621826842_8488291201.0MotifNote=ALG-2-binding site motif-2 (ABS-2)%2C
TgeneSEC31Achr4:83719459chr4:83765662ENST000004483231927842_8488341221.0MotifNote=ALG-2-binding site motif-2 (ABS-2)%2C
TgeneSEC31Achr4:83719459chr4:83765662ENST000005007771623842_8487951068.0MotifNote=ALG-2-binding site motif-2 (ABS-2)%2C
TgeneSEC31Achr4:83719459chr4:83765662ENST000005085021927842_8488341206.0MotifNote=ALG-2-binding site motif-2 (ABS-2)%2C
TgeneSEC31Achr4:83719459chr4:83765662ENST000005091421926842_8488341107.0MotifNote=ALG-2-binding site motif-2 (ABS-2)%2C
TgeneSEC31Achr4:83719459chr4:83765662ENST000005138581724842_8487951068.0MotifNote=ALG-2-binding site motif-2 (ABS-2)%2C

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSCD5chr4:83719459chr4:83765662ENST00000273908-14131_13577257.0MotifHistidine box-2
HgeneSCD5chr4:83719459chr4:83765662ENST00000273908-14272_27677257.0MotifHistidine box-3
HgeneSCD5chr4:83719459chr4:83765662ENST00000273908-1494_9977257.0MotifHistidine box-1
HgeneSCD5chr4:83719459chr4:83765662ENST00000319540-15131_13577331.0MotifHistidine box-2
HgeneSCD5chr4:83719459chr4:83765662ENST00000319540-15272_27677331.0MotifHistidine box-3
HgeneSCD5chr4:83719459chr4:83765662ENST00000319540-1594_9977331.0MotifHistidine box-1
HgeneSCD5chr4:83719459chr4:83765662ENST00000273908-14215_21577257.0Topological domainLumenal
HgeneSCD5chr4:83719459chr4:83765662ENST00000273908-14239_33077257.0Topological domainCytoplasmic
HgeneSCD5chr4:83719459chr4:83765662ENST00000273908-1494_19377257.0Topological domainCytoplasmic
HgeneSCD5chr4:83719459chr4:83765662ENST00000319540-15215_21577331.0Topological domainLumenal
HgeneSCD5chr4:83719459chr4:83765662ENST00000319540-15239_33077331.0Topological domainCytoplasmic
HgeneSCD5chr4:83719459chr4:83765662ENST00000319540-1594_19377331.0Topological domainCytoplasmic
HgeneSCD5chr4:83719459chr4:83765662ENST00000273908-14194_21477257.0TransmembraneHelical
HgeneSCD5chr4:83719459chr4:83765662ENST00000273908-14216_23877257.0TransmembraneHelical
HgeneSCD5chr4:83719459chr4:83765662ENST00000273908-1473_9377257.0TransmembraneHelical
HgeneSCD5chr4:83719459chr4:83765662ENST00000319540-15194_21477331.0TransmembraneHelical
HgeneSCD5chr4:83719459chr4:83765662ENST00000319540-15216_23877331.0TransmembraneHelical
HgeneSCD5chr4:83719459chr4:83765662ENST00000319540-1573_9377331.0TransmembraneHelical
TgeneSEC31Achr4:83719459chr4:83765662ENST000003117851926800_10918341107.0Compositional biasNote=Pro-rich
TgeneSEC31Achr4:83719459chr4:83765662ENST000003551962129800_10918341221.0Compositional biasNote=Pro-rich
TgeneSEC31Achr4:83719459chr4:83765662ENST000003953101927800_10918341221.0Compositional biasNote=Pro-rich
TgeneSEC31Achr4:83719459chr4:83765662ENST000004327941928800_10918341234.0Compositional biasNote=Pro-rich
TgeneSEC31Achr4:83719459chr4:83765662ENST000004434621826800_10918291201.0Compositional biasNote=Pro-rich
TgeneSEC31Achr4:83719459chr4:83765662ENST000004483231927800_10918341221.0Compositional biasNote=Pro-rich
TgeneSEC31Achr4:83719459chr4:83765662ENST000005085021927800_10918341206.0Compositional biasNote=Pro-rich
TgeneSEC31Achr4:83719459chr4:83765662ENST000005091421926800_10918341107.0Compositional biasNote=Pro-rich
TgeneSEC31Achr4:83719459chr4:83765662ENST000003117851926120_1608341107.0RepeatNote=WD 3
TgeneSEC31Achr4:83719459chr4:83765662ENST000003117851926166_2068341107.0RepeatNote=WD 4
TgeneSEC31Achr4:83719459chr4:83765662ENST000003117851926209_2548341107.0RepeatNote=WD 5
TgeneSEC31Achr4:83719459chr4:83765662ENST000003117851926258_2988341107.0RepeatNote=WD 6
TgeneSEC31Achr4:83719459chr4:83765662ENST000003117851926301_3428341107.0RepeatNote=WD 7
TgeneSEC31Achr4:83719459chr4:83765662ENST0000031178519264_478341107.0RepeatNote=WD 1
TgeneSEC31Achr4:83719459chr4:83765662ENST00000311785192668_1118341107.0RepeatNote=WD 2
TgeneSEC31Achr4:83719459chr4:83765662ENST000003269501725120_1607951182.0RepeatNote=WD 3
TgeneSEC31Achr4:83719459chr4:83765662ENST000003269501725166_2067951182.0RepeatNote=WD 4
TgeneSEC31Achr4:83719459chr4:83765662ENST000003269501725209_2547951182.0RepeatNote=WD 5
TgeneSEC31Achr4:83719459chr4:83765662ENST000003269501725258_2987951182.0RepeatNote=WD 6
TgeneSEC31Achr4:83719459chr4:83765662ENST000003269501725301_3427951182.0RepeatNote=WD 7
TgeneSEC31Achr4:83719459chr4:83765662ENST0000032695017254_477951182.0RepeatNote=WD 1
TgeneSEC31Achr4:83719459chr4:83765662ENST00000326950172568_1117951182.0RepeatNote=WD 2
TgeneSEC31Achr4:83719459chr4:83765662ENST000003484051725120_1607951182.0RepeatNote=WD 3
TgeneSEC31Achr4:83719459chr4:83765662ENST000003484051725166_2067951182.0RepeatNote=WD 4
TgeneSEC31Achr4:83719459chr4:83765662ENST000003484051725209_2547951182.0RepeatNote=WD 5
TgeneSEC31Achr4:83719459chr4:83765662ENST000003484051725258_2987951182.0RepeatNote=WD 6
TgeneSEC31Achr4:83719459chr4:83765662ENST000003484051725301_3427951182.0RepeatNote=WD 7
TgeneSEC31Achr4:83719459chr4:83765662ENST0000034840517254_477951182.0RepeatNote=WD 1
TgeneSEC31Achr4:83719459chr4:83765662ENST00000348405172568_1117951182.0RepeatNote=WD 2
TgeneSEC31Achr4:83719459chr4:83765662ENST000003551962129120_1608341221.0RepeatNote=WD 3
TgeneSEC31Achr4:83719459chr4:83765662ENST000003551962129166_2068341221.0RepeatNote=WD 4
TgeneSEC31Achr4:83719459chr4:83765662ENST000003551962129209_2548341221.0RepeatNote=WD 5
TgeneSEC31Achr4:83719459chr4:83765662ENST000003551962129258_2988341221.0RepeatNote=WD 6
TgeneSEC31Achr4:83719459chr4:83765662ENST000003551962129301_3428341221.0RepeatNote=WD 7
TgeneSEC31Achr4:83719459chr4:83765662ENST0000035519621294_478341221.0RepeatNote=WD 1
TgeneSEC31Achr4:83719459chr4:83765662ENST00000355196212968_1118341221.0RepeatNote=WD 2
TgeneSEC31Achr4:83719459chr4:83765662ENST000003953101927120_1608341221.0RepeatNote=WD 3
TgeneSEC31Achr4:83719459chr4:83765662ENST000003953101927166_2068341221.0RepeatNote=WD 4
TgeneSEC31Achr4:83719459chr4:83765662ENST000003953101927209_2548341221.0RepeatNote=WD 5
TgeneSEC31Achr4:83719459chr4:83765662ENST000003953101927258_2988341221.0RepeatNote=WD 6
TgeneSEC31Achr4:83719459chr4:83765662ENST000003953101927301_3428341221.0RepeatNote=WD 7
TgeneSEC31Achr4:83719459chr4:83765662ENST0000039531019274_478341221.0RepeatNote=WD 1
TgeneSEC31Achr4:83719459chr4:83765662ENST00000395310192768_1118341221.0RepeatNote=WD 2
TgeneSEC31Achr4:83719459chr4:83765662ENST000004327941928120_1608341234.0RepeatNote=WD 3
TgeneSEC31Achr4:83719459chr4:83765662ENST000004327941928166_2068341234.0RepeatNote=WD 4
TgeneSEC31Achr4:83719459chr4:83765662ENST000004327941928209_2548341234.0RepeatNote=WD 5
TgeneSEC31Achr4:83719459chr4:83765662ENST000004327941928258_2988341234.0RepeatNote=WD 6
TgeneSEC31Achr4:83719459chr4:83765662ENST000004327941928301_3428341234.0RepeatNote=WD 7
TgeneSEC31Achr4:83719459chr4:83765662ENST0000043279419284_478341234.0RepeatNote=WD 1
TgeneSEC31Achr4:83719459chr4:83765662ENST00000432794192868_1118341234.0RepeatNote=WD 2
TgeneSEC31Achr4:83719459chr4:83765662ENST000004434621826120_1608291201.0RepeatNote=WD 3
TgeneSEC31Achr4:83719459chr4:83765662ENST000004434621826166_2068291201.0RepeatNote=WD 4
TgeneSEC31Achr4:83719459chr4:83765662ENST000004434621826209_2548291201.0RepeatNote=WD 5
TgeneSEC31Achr4:83719459chr4:83765662ENST000004434621826258_2988291201.0RepeatNote=WD 6
TgeneSEC31Achr4:83719459chr4:83765662ENST000004434621826301_3428291201.0RepeatNote=WD 7
TgeneSEC31Achr4:83719459chr4:83765662ENST0000044346218264_478291201.0RepeatNote=WD 1
TgeneSEC31Achr4:83719459chr4:83765662ENST00000443462182668_1118291201.0RepeatNote=WD 2
TgeneSEC31Achr4:83719459chr4:83765662ENST000004483231927120_1608341221.0RepeatNote=WD 3
TgeneSEC31Achr4:83719459chr4:83765662ENST000004483231927166_2068341221.0RepeatNote=WD 4
TgeneSEC31Achr4:83719459chr4:83765662ENST000004483231927209_2548341221.0RepeatNote=WD 5
TgeneSEC31Achr4:83719459chr4:83765662ENST000004483231927258_2988341221.0RepeatNote=WD 6
TgeneSEC31Achr4:83719459chr4:83765662ENST000004483231927301_3428341221.0RepeatNote=WD 7
TgeneSEC31Achr4:83719459chr4:83765662ENST0000044832319274_478341221.0RepeatNote=WD 1
TgeneSEC31Achr4:83719459chr4:83765662ENST00000448323192768_1118341221.0RepeatNote=WD 2
TgeneSEC31Achr4:83719459chr4:83765662ENST000005007771623120_1607951068.0RepeatNote=WD 3
TgeneSEC31Achr4:83719459chr4:83765662ENST000005007771623166_2067951068.0RepeatNote=WD 4
TgeneSEC31Achr4:83719459chr4:83765662ENST000005007771623209_2547951068.0RepeatNote=WD 5
TgeneSEC31Achr4:83719459chr4:83765662ENST000005007771623258_2987951068.0RepeatNote=WD 6
TgeneSEC31Achr4:83719459chr4:83765662ENST000005007771623301_3427951068.0RepeatNote=WD 7
TgeneSEC31Achr4:83719459chr4:83765662ENST0000050077716234_477951068.0RepeatNote=WD 1
TgeneSEC31Achr4:83719459chr4:83765662ENST00000500777162368_1117951068.0RepeatNote=WD 2
TgeneSEC31Achr4:83719459chr4:83765662ENST000005085021927120_1608341206.0RepeatNote=WD 3
TgeneSEC31Achr4:83719459chr4:83765662ENST000005085021927166_2068341206.0RepeatNote=WD 4
TgeneSEC31Achr4:83719459chr4:83765662ENST000005085021927209_2548341206.0RepeatNote=WD 5
TgeneSEC31Achr4:83719459chr4:83765662ENST000005085021927258_2988341206.0RepeatNote=WD 6
TgeneSEC31Achr4:83719459chr4:83765662ENST000005085021927301_3428341206.0RepeatNote=WD 7
TgeneSEC31Achr4:83719459chr4:83765662ENST0000050850219274_478341206.0RepeatNote=WD 1
TgeneSEC31Achr4:83719459chr4:83765662ENST00000508502192768_1118341206.0RepeatNote=WD 2
TgeneSEC31Achr4:83719459chr4:83765662ENST000005091421926120_1608341107.0RepeatNote=WD 3
TgeneSEC31Achr4:83719459chr4:83765662ENST000005091421926166_2068341107.0RepeatNote=WD 4
TgeneSEC31Achr4:83719459chr4:83765662ENST000005091421926209_2548341107.0RepeatNote=WD 5
TgeneSEC31Achr4:83719459chr4:83765662ENST000005091421926258_2988341107.0RepeatNote=WD 6
TgeneSEC31Achr4:83719459chr4:83765662ENST000005091421926301_3428341107.0RepeatNote=WD 7
TgeneSEC31Achr4:83719459chr4:83765662ENST0000050914219264_478341107.0RepeatNote=WD 1
TgeneSEC31Achr4:83719459chr4:83765662ENST00000509142192668_1118341107.0RepeatNote=WD 2
TgeneSEC31Achr4:83719459chr4:83765662ENST000005138581724120_1607951068.0RepeatNote=WD 3
TgeneSEC31Achr4:83719459chr4:83765662ENST000005138581724166_2067951068.0RepeatNote=WD 4
TgeneSEC31Achr4:83719459chr4:83765662ENST000005138581724209_2547951068.0RepeatNote=WD 5
TgeneSEC31Achr4:83719459chr4:83765662ENST000005138581724258_2987951068.0RepeatNote=WD 6
TgeneSEC31Achr4:83719459chr4:83765662ENST000005138581724301_3427951068.0RepeatNote=WD 7
TgeneSEC31Achr4:83719459chr4:83765662ENST0000051385817244_477951068.0RepeatNote=WD 1
TgeneSEC31Achr4:83719459chr4:83765662ENST00000513858172468_1117951068.0RepeatNote=WD 2


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Fusion Gene Sequence for SCD5-SEC31A


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for SCD5-SEC31A


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
TgeneSEC31Achr4:83719459chr4:83765662ENST000003269501725800_1113795.01182.0PDCD6
TgeneSEC31Achr4:83719459chr4:83765662ENST000003484051725800_1113795.01182.0PDCD6
TgeneSEC31Achr4:83719459chr4:83765662ENST000005007771623800_1113795.01068.0PDCD6
TgeneSEC31Achr4:83719459chr4:83765662ENST000005138581724800_1113795.01068.0PDCD6


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
TgeneSEC31Achr4:83719459chr4:83765662ENST000003117851926800_1113834.01107.0PDCD6
TgeneSEC31Achr4:83719459chr4:83765662ENST000003551962129800_1113834.01221.0PDCD6
TgeneSEC31Achr4:83719459chr4:83765662ENST000003953101927800_1113834.01221.0PDCD6
TgeneSEC31Achr4:83719459chr4:83765662ENST000004327941928800_1113834.01234.0PDCD6
TgeneSEC31Achr4:83719459chr4:83765662ENST000004434621826800_1113829.01201.0PDCD6
TgeneSEC31Achr4:83719459chr4:83765662ENST000004483231927800_1113834.01221.0PDCD6
TgeneSEC31Achr4:83719459chr4:83765662ENST000005085021927800_1113834.01206.0PDCD6
TgeneSEC31Achr4:83719459chr4:83765662ENST000005091421926800_1113834.01107.0PDCD6
TgeneSEC31Achr4:83719459chr4:83765662ENST000003117851926161_471834.01107.0SEC13
TgeneSEC31Achr4:83719459chr4:83765662ENST000003269501725161_471795.01182.0SEC13
TgeneSEC31Achr4:83719459chr4:83765662ENST000003484051725161_471795.01182.0SEC13
TgeneSEC31Achr4:83719459chr4:83765662ENST000003551962129161_471834.01221.0SEC13
TgeneSEC31Achr4:83719459chr4:83765662ENST000003953101927161_471834.01221.0SEC13
TgeneSEC31Achr4:83719459chr4:83765662ENST000004327941928161_471834.01234.0SEC13
TgeneSEC31Achr4:83719459chr4:83765662ENST000004434621826161_471829.01201.0SEC13
TgeneSEC31Achr4:83719459chr4:83765662ENST000004483231927161_471834.01221.0SEC13
TgeneSEC31Achr4:83719459chr4:83765662ENST000005007771623161_471795.01068.0SEC13
TgeneSEC31Achr4:83719459chr4:83765662ENST000005085021927161_471834.01206.0SEC13
TgeneSEC31Achr4:83719459chr4:83765662ENST000005091421926161_471834.01107.0SEC13
TgeneSEC31Achr4:83719459chr4:83765662ENST000005138581724161_471795.01068.0SEC13


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for SCD5-SEC31A


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for SCD5-SEC31A


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource