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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:SCMH1-CUL3 (FusionGDB2 ID:79648)

Fusion Gene Summary for SCMH1-CUL3

Fusion gene summary

Fusion gene information	Fusion gene name: SCMH1-CUL3
	Fusion gene ID: 79648
		Hgene	Tgene
	Gene symbol	SCMH1	CUL3
	Gene ID	22955	8452
	Gene name	Scm polycomb group protein homolog 1	cullin 3
	Synonyms	Scml3	CUL-3\|PHA2E
	Cytomap	1p34.2	2q36.2
	Type of gene	protein-coding	protein-coding
	Description	polycomb protein SCMH1sex comb on midleg homolog 1	cullin-3
	Modification date	20200313	20200327
	UniProtAcc	.	Q13618
	Ensembl transtripts involved in fusion gene	ENST00000337495, ENST00000372596, ENST00000372597, ENST00000326197, ENST00000361191, ENST00000361705, ENST00000372595, ENST00000397171, ENST00000397174, ENST00000402904, ENST00000456518, ENST00000472037,	ENST00000264414, ENST00000344951, ENST00000409096, ENST00000409777, ENST00000432260,
Fusion gene scores	* DoF score	18 X 14 X 11=2772	8 X 8 X 5=320
	# samples	24	9
	** MAII score	log2(24/2772*10)=-3.52982094652869 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(9/320*10)=-1.83007499855769 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: SCMH1 [Title/Abstract] AND CUL3 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	SCMH1(41707731)-CUL3(225343062), # samples:2 SCMH1(41707731)-CUL3(225346795), # samples:2
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	CUL3	GO:0000209	protein polyubiquitination	19261606
Tgene	CUL3	GO:0006511	ubiquitin-dependent protein catabolic process	25401743\|27561354
Tgene	CUL3	GO:0006513	protein monoubiquitination	22358839
Tgene	CUL3	GO:0006888	ER to Golgi vesicle-mediated transport	22358839
Tgene	CUL3	GO:0016567	protein ubiquitination	17543862\|19782033\|19995937\|20389280\|23213400
Tgene	CUL3	GO:0031145	anaphase-promoting complex-dependent catabolic process	10500095
Tgene	CUL3	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	19261606\|19782033\|20389280
Tgene	CUL3	GO:0071630	nuclear protein quality control by the ubiquitin-proteasome system	27561354

Fusion gene breakpoints across SCMH1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across CUL3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	LUAD	TCGA-44-7670-01A	SCMH1	chr1	41707731	-	CUL3	chr2	225343062	-
ChimerDB4	LUAD	TCGA-44-7670-01A	SCMH1	chr1	41707731	-	CUL3	chr2	225346795	-
ChimerDB4	LUAD	TCGA-44-7670	SCMH1	chr1	41707730	-	CUL3	chr2	225346795	-

Top

Fusion Gene ORF analysis for SCMH1-CUL3

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5UTR-3CDS	ENST00000337495	ENST00000264414	SCMH1	chr1	41707731	-	CUL3	chr2	225343062	-
5UTR-3CDS	ENST00000337495	ENST00000264414	SCMH1	chr1	41707731	-	CUL3	chr2	225346795	-
5UTR-3CDS	ENST00000337495	ENST00000264414	SCMH1	chr1	41707730	-	CUL3	chr2	225346795	-
5UTR-3CDS	ENST00000337495	ENST00000344951	SCMH1	chr1	41707731	-	CUL3	chr2	225343062	-
5UTR-3CDS	ENST00000337495	ENST00000344951	SCMH1	chr1	41707731	-	CUL3	chr2	225346795	-
5UTR-3CDS	ENST00000337495	ENST00000344951	SCMH1	chr1	41707730	-	CUL3	chr2	225346795	-
5UTR-3CDS	ENST00000337495	ENST00000409096	SCMH1	chr1	41707731	-	CUL3	chr2	225343062	-
5UTR-3CDS	ENST00000337495	ENST00000409096	SCMH1	chr1	41707731	-	CUL3	chr2	225346795	-
5UTR-3CDS	ENST00000337495	ENST00000409096	SCMH1	chr1	41707730	-	CUL3	chr2	225346795	-
5UTR-3CDS	ENST00000337495	ENST00000409777	SCMH1	chr1	41707731	-	CUL3	chr2	225343062	-
5UTR-3CDS	ENST00000337495	ENST00000409777	SCMH1	chr1	41707731	-	CUL3	chr2	225346795	-
5UTR-3CDS	ENST00000337495	ENST00000409777	SCMH1	chr1	41707730	-	CUL3	chr2	225346795	-
5UTR-3CDS	ENST00000372596	ENST00000264414	SCMH1	chr1	41707731	-	CUL3	chr2	225343062	-
5UTR-3CDS	ENST00000372596	ENST00000264414	SCMH1	chr1	41707731	-	CUL3	chr2	225346795	-
5UTR-3CDS	ENST00000372596	ENST00000264414	SCMH1	chr1	41707730	-	CUL3	chr2	225346795	-
5UTR-3CDS	ENST00000372596	ENST00000344951	SCMH1	chr1	41707731	-	CUL3	chr2	225343062	-
5UTR-3CDS	ENST00000372596	ENST00000344951	SCMH1	chr1	41707731	-	CUL3	chr2	225346795	-
5UTR-3CDS	ENST00000372596	ENST00000344951	SCMH1	chr1	41707730	-	CUL3	chr2	225346795	-
5UTR-3CDS	ENST00000372596	ENST00000409096	SCMH1	chr1	41707731	-	CUL3	chr2	225343062	-
5UTR-3CDS	ENST00000372596	ENST00000409096	SCMH1	chr1	41707731	-	CUL3	chr2	225346795	-
5UTR-3CDS	ENST00000372596	ENST00000409096	SCMH1	chr1	41707730	-	CUL3	chr2	225346795	-
5UTR-3CDS	ENST00000372596	ENST00000409777	SCMH1	chr1	41707731	-	CUL3	chr2	225343062	-
5UTR-3CDS	ENST00000372596	ENST00000409777	SCMH1	chr1	41707731	-	CUL3	chr2	225346795	-
5UTR-3CDS	ENST00000372596	ENST00000409777	SCMH1	chr1	41707730	-	CUL3	chr2	225346795	-
5UTR-3CDS	ENST00000372597	ENST00000264414	SCMH1	chr1	41707731	-	CUL3	chr2	225343062	-
5UTR-3CDS	ENST00000372597	ENST00000264414	SCMH1	chr1	41707731	-	CUL3	chr2	225346795	-
5UTR-3CDS	ENST00000372597	ENST00000264414	SCMH1	chr1	41707730	-	CUL3	chr2	225346795	-
5UTR-3CDS	ENST00000372597	ENST00000344951	SCMH1	chr1	41707731	-	CUL3	chr2	225343062	-
5UTR-3CDS	ENST00000372597	ENST00000344951	SCMH1	chr1	41707731	-	CUL3	chr2	225346795	-
5UTR-3CDS	ENST00000372597	ENST00000344951	SCMH1	chr1	41707730	-	CUL3	chr2	225346795	-
5UTR-3CDS	ENST00000372597	ENST00000409096	SCMH1	chr1	41707731	-	CUL3	chr2	225343062	-
5UTR-3CDS	ENST00000372597	ENST00000409096	SCMH1	chr1	41707731	-	CUL3	chr2	225346795	-
5UTR-3CDS	ENST00000372597	ENST00000409096	SCMH1	chr1	41707730	-	CUL3	chr2	225346795	-
5UTR-3CDS	ENST00000372597	ENST00000409777	SCMH1	chr1	41707731	-	CUL3	chr2	225343062	-
5UTR-3CDS	ENST00000372597	ENST00000409777	SCMH1	chr1	41707731	-	CUL3	chr2	225346795	-
5UTR-3CDS	ENST00000372597	ENST00000409777	SCMH1	chr1	41707730	-	CUL3	chr2	225346795	-
5UTR-intron	ENST00000337495	ENST00000432260	SCMH1	chr1	41707731	-	CUL3	chr2	225343062	-
5UTR-intron	ENST00000337495	ENST00000432260	SCMH1	chr1	41707731	-	CUL3	chr2	225346795	-
5UTR-intron	ENST00000337495	ENST00000432260	SCMH1	chr1	41707730	-	CUL3	chr2	225346795	-
5UTR-intron	ENST00000372596	ENST00000432260	SCMH1	chr1	41707731	-	CUL3	chr2	225343062	-
5UTR-intron	ENST00000372596	ENST00000432260	SCMH1	chr1	41707731	-	CUL3	chr2	225346795	-
5UTR-intron	ENST00000372596	ENST00000432260	SCMH1	chr1	41707730	-	CUL3	chr2	225346795	-
5UTR-intron	ENST00000372597	ENST00000432260	SCMH1	chr1	41707731	-	CUL3	chr2	225343062	-
5UTR-intron	ENST00000372597	ENST00000432260	SCMH1	chr1	41707731	-	CUL3	chr2	225346795	-
5UTR-intron	ENST00000372597	ENST00000432260	SCMH1	chr1	41707730	-	CUL3	chr2	225346795	-
intron-3CDS	ENST00000326197	ENST00000264414	SCMH1	chr1	41707731	-	CUL3	chr2	225343062	-
intron-3CDS	ENST00000326197	ENST00000264414	SCMH1	chr1	41707731	-	CUL3	chr2	225346795	-
intron-3CDS	ENST00000326197	ENST00000264414	SCMH1	chr1	41707730	-	CUL3	chr2	225346795	-
intron-3CDS	ENST00000326197	ENST00000344951	SCMH1	chr1	41707731	-	CUL3	chr2	225343062	-
intron-3CDS	ENST00000326197	ENST00000344951	SCMH1	chr1	41707731	-	CUL3	chr2	225346795	-
intron-3CDS	ENST00000326197	ENST00000344951	SCMH1	chr1	41707730	-	CUL3	chr2	225346795	-
intron-3CDS	ENST00000326197	ENST00000409096	SCMH1	chr1	41707731	-	CUL3	chr2	225343062	-
intron-3CDS	ENST00000326197	ENST00000409096	SCMH1	chr1	41707731	-	CUL3	chr2	225346795	-
intron-3CDS	ENST00000326197	ENST00000409096	SCMH1	chr1	41707730	-	CUL3	chr2	225346795	-
intron-3CDS	ENST00000326197	ENST00000409777	SCMH1	chr1	41707731	-	CUL3	chr2	225343062	-
intron-3CDS	ENST00000326197	ENST00000409777	SCMH1	chr1	41707731	-	CUL3	chr2	225346795	-
intron-3CDS	ENST00000326197	ENST00000409777	SCMH1	chr1	41707730	-	CUL3	chr2	225346795	-
intron-3CDS	ENST00000361191	ENST00000264414	SCMH1	chr1	41707731	-	CUL3	chr2	225343062	-
intron-3CDS	ENST00000361191	ENST00000264414	SCMH1	chr1	41707731	-	CUL3	chr2	225346795	-
intron-3CDS	ENST00000361191	ENST00000264414	SCMH1	chr1	41707730	-	CUL3	chr2	225346795	-
intron-3CDS	ENST00000361191	ENST00000344951	SCMH1	chr1	41707731	-	CUL3	chr2	225343062	-
intron-3CDS	ENST00000361191	ENST00000344951	SCMH1	chr1	41707731	-	CUL3	chr2	225346795	-
intron-3CDS	ENST00000361191	ENST00000344951	SCMH1	chr1	41707730	-	CUL3	chr2	225346795	-
intron-3CDS	ENST00000361191	ENST00000409096	SCMH1	chr1	41707731	-	CUL3	chr2	225343062	-
intron-3CDS	ENST00000361191	ENST00000409096	SCMH1	chr1	41707731	-	CUL3	chr2	225346795	-
intron-3CDS	ENST00000361191	ENST00000409096	SCMH1	chr1	41707730	-	CUL3	chr2	225346795	-
intron-3CDS	ENST00000361191	ENST00000409777	SCMH1	chr1	41707731	-	CUL3	chr2	225343062	-
intron-3CDS	ENST00000361191	ENST00000409777	SCMH1	chr1	41707731	-	CUL3	chr2	225346795	-
intron-3CDS	ENST00000361191	ENST00000409777	SCMH1	chr1	41707730	-	CUL3	chr2	225346795	-
intron-3CDS	ENST00000361705	ENST00000264414	SCMH1	chr1	41707731	-	CUL3	chr2	225343062	-
intron-3CDS	ENST00000361705	ENST00000264414	SCMH1	chr1	41707731	-	CUL3	chr2	225346795	-
intron-3CDS	ENST00000361705	ENST00000264414	SCMH1	chr1	41707730	-	CUL3	chr2	225346795	-
intron-3CDS	ENST00000361705	ENST00000344951	SCMH1	chr1	41707731	-	CUL3	chr2	225343062	-
intron-3CDS	ENST00000361705	ENST00000344951	SCMH1	chr1	41707731	-	CUL3	chr2	225346795	-
intron-3CDS	ENST00000361705	ENST00000344951	SCMH1	chr1	41707730	-	CUL3	chr2	225346795	-
intron-3CDS	ENST00000361705	ENST00000409096	SCMH1	chr1	41707731	-	CUL3	chr2	225343062	-
intron-3CDS	ENST00000361705	ENST00000409096	SCMH1	chr1	41707731	-	CUL3	chr2	225346795	-
intron-3CDS	ENST00000361705	ENST00000409096	SCMH1	chr1	41707730	-	CUL3	chr2	225346795	-
intron-3CDS	ENST00000361705	ENST00000409777	SCMH1	chr1	41707731	-	CUL3	chr2	225343062	-
intron-3CDS	ENST00000361705	ENST00000409777	SCMH1	chr1	41707731	-	CUL3	chr2	225346795	-
intron-3CDS	ENST00000361705	ENST00000409777	SCMH1	chr1	41707730	-	CUL3	chr2	225346795	-
intron-3CDS	ENST00000372595	ENST00000264414	SCMH1	chr1	41707731	-	CUL3	chr2	225343062	-
intron-3CDS	ENST00000372595	ENST00000264414	SCMH1	chr1	41707731	-	CUL3	chr2	225346795	-
intron-3CDS	ENST00000372595	ENST00000264414	SCMH1	chr1	41707730	-	CUL3	chr2	225346795	-
intron-3CDS	ENST00000372595	ENST00000344951	SCMH1	chr1	41707731	-	CUL3	chr2	225343062	-
intron-3CDS	ENST00000372595	ENST00000344951	SCMH1	chr1	41707731	-	CUL3	chr2	225346795	-
intron-3CDS	ENST00000372595	ENST00000344951	SCMH1	chr1	41707730	-	CUL3	chr2	225346795	-
intron-3CDS	ENST00000372595	ENST00000409096	SCMH1	chr1	41707731	-	CUL3	chr2	225343062	-
intron-3CDS	ENST00000372595	ENST00000409096	SCMH1	chr1	41707731	-	CUL3	chr2	225346795	-
intron-3CDS	ENST00000372595	ENST00000409096	SCMH1	chr1	41707730	-	CUL3	chr2	225346795	-
intron-3CDS	ENST00000372595	ENST00000409777	SCMH1	chr1	41707731	-	CUL3	chr2	225343062	-
intron-3CDS	ENST00000372595	ENST00000409777	SCMH1	chr1	41707731	-	CUL3	chr2	225346795	-
intron-3CDS	ENST00000372595	ENST00000409777	SCMH1	chr1	41707730	-	CUL3	chr2	225346795	-
intron-3CDS	ENST00000397171	ENST00000264414	SCMH1	chr1	41707731	-	CUL3	chr2	225343062	-
intron-3CDS	ENST00000397171	ENST00000264414	SCMH1	chr1	41707731	-	CUL3	chr2	225346795	-
intron-3CDS	ENST00000397171	ENST00000264414	SCMH1	chr1	41707730	-	CUL3	chr2	225346795	-
intron-3CDS	ENST00000397171	ENST00000344951	SCMH1	chr1	41707731	-	CUL3	chr2	225343062	-
intron-3CDS	ENST00000397171	ENST00000344951	SCMH1	chr1	41707731	-	CUL3	chr2	225346795	-
intron-3CDS	ENST00000397171	ENST00000344951	SCMH1	chr1	41707730	-	CUL3	chr2	225346795	-
intron-3CDS	ENST00000397171	ENST00000409096	SCMH1	chr1	41707731	-	CUL3	chr2	225343062	-
intron-3CDS	ENST00000397171	ENST00000409096	SCMH1	chr1	41707731	-	CUL3	chr2	225346795	-
intron-3CDS	ENST00000397171	ENST00000409096	SCMH1	chr1	41707730	-	CUL3	chr2	225346795	-
intron-3CDS	ENST00000397171	ENST00000409777	SCMH1	chr1	41707731	-	CUL3	chr2	225343062	-
intron-3CDS	ENST00000397171	ENST00000409777	SCMH1	chr1	41707731	-	CUL3	chr2	225346795	-
intron-3CDS	ENST00000397171	ENST00000409777	SCMH1	chr1	41707730	-	CUL3	chr2	225346795	-
intron-3CDS	ENST00000397174	ENST00000264414	SCMH1	chr1	41707731	-	CUL3	chr2	225343062	-
intron-3CDS	ENST00000397174	ENST00000264414	SCMH1	chr1	41707731	-	CUL3	chr2	225346795	-
intron-3CDS	ENST00000397174	ENST00000264414	SCMH1	chr1	41707730	-	CUL3	chr2	225346795	-
intron-3CDS	ENST00000397174	ENST00000344951	SCMH1	chr1	41707731	-	CUL3	chr2	225343062	-
intron-3CDS	ENST00000397174	ENST00000344951	SCMH1	chr1	41707731	-	CUL3	chr2	225346795	-
intron-3CDS	ENST00000397174	ENST00000344951	SCMH1	chr1	41707730	-	CUL3	chr2	225346795	-
intron-3CDS	ENST00000397174	ENST00000409096	SCMH1	chr1	41707731	-	CUL3	chr2	225343062	-
intron-3CDS	ENST00000397174	ENST00000409096	SCMH1	chr1	41707731	-	CUL3	chr2	225346795	-
intron-3CDS	ENST00000397174	ENST00000409096	SCMH1	chr1	41707730	-	CUL3	chr2	225346795	-
intron-3CDS	ENST00000397174	ENST00000409777	SCMH1	chr1	41707731	-	CUL3	chr2	225343062	-
intron-3CDS	ENST00000397174	ENST00000409777	SCMH1	chr1	41707731	-	CUL3	chr2	225346795	-
intron-3CDS	ENST00000397174	ENST00000409777	SCMH1	chr1	41707730	-	CUL3	chr2	225346795	-
intron-3CDS	ENST00000402904	ENST00000264414	SCMH1	chr1	41707731	-	CUL3	chr2	225343062	-
intron-3CDS	ENST00000402904	ENST00000264414	SCMH1	chr1	41707731	-	CUL3	chr2	225346795	-
intron-3CDS	ENST00000402904	ENST00000264414	SCMH1	chr1	41707730	-	CUL3	chr2	225346795	-
intron-3CDS	ENST00000402904	ENST00000344951	SCMH1	chr1	41707731	-	CUL3	chr2	225343062	-
intron-3CDS	ENST00000402904	ENST00000344951	SCMH1	chr1	41707731	-	CUL3	chr2	225346795	-
intron-3CDS	ENST00000402904	ENST00000344951	SCMH1	chr1	41707730	-	CUL3	chr2	225346795	-
intron-3CDS	ENST00000402904	ENST00000409096	SCMH1	chr1	41707731	-	CUL3	chr2	225343062	-
intron-3CDS	ENST00000402904	ENST00000409096	SCMH1	chr1	41707731	-	CUL3	chr2	225346795	-
intron-3CDS	ENST00000402904	ENST00000409096	SCMH1	chr1	41707730	-	CUL3	chr2	225346795	-
intron-3CDS	ENST00000402904	ENST00000409777	SCMH1	chr1	41707731	-	CUL3	chr2	225343062	-
intron-3CDS	ENST00000402904	ENST00000409777	SCMH1	chr1	41707731	-	CUL3	chr2	225346795	-
intron-3CDS	ENST00000402904	ENST00000409777	SCMH1	chr1	41707730	-	CUL3	chr2	225346795	-
intron-3CDS	ENST00000456518	ENST00000264414	SCMH1	chr1	41707731	-	CUL3	chr2	225343062	-
intron-3CDS	ENST00000456518	ENST00000264414	SCMH1	chr1	41707731	-	CUL3	chr2	225346795	-
intron-3CDS	ENST00000456518	ENST00000264414	SCMH1	chr1	41707730	-	CUL3	chr2	225346795	-
intron-3CDS	ENST00000456518	ENST00000344951	SCMH1	chr1	41707731	-	CUL3	chr2	225343062	-
intron-3CDS	ENST00000456518	ENST00000344951	SCMH1	chr1	41707731	-	CUL3	chr2	225346795	-
intron-3CDS	ENST00000456518	ENST00000344951	SCMH1	chr1	41707730	-	CUL3	chr2	225346795	-
intron-3CDS	ENST00000456518	ENST00000409096	SCMH1	chr1	41707731	-	CUL3	chr2	225343062	-
intron-3CDS	ENST00000456518	ENST00000409096	SCMH1	chr1	41707731	-	CUL3	chr2	225346795	-
intron-3CDS	ENST00000456518	ENST00000409096	SCMH1	chr1	41707730	-	CUL3	chr2	225346795	-
intron-3CDS	ENST00000456518	ENST00000409777	SCMH1	chr1	41707731	-	CUL3	chr2	225343062	-
intron-3CDS	ENST00000456518	ENST00000409777	SCMH1	chr1	41707731	-	CUL3	chr2	225346795	-
intron-3CDS	ENST00000456518	ENST00000409777	SCMH1	chr1	41707730	-	CUL3	chr2	225346795	-
intron-3CDS	ENST00000472037	ENST00000264414	SCMH1	chr1	41707731	-	CUL3	chr2	225343062	-
intron-3CDS	ENST00000472037	ENST00000264414	SCMH1	chr1	41707731	-	CUL3	chr2	225346795	-
intron-3CDS	ENST00000472037	ENST00000264414	SCMH1	chr1	41707730	-	CUL3	chr2	225346795	-
intron-3CDS	ENST00000472037	ENST00000344951	SCMH1	chr1	41707731	-	CUL3	chr2	225343062	-
intron-3CDS	ENST00000472037	ENST00000344951	SCMH1	chr1	41707731	-	CUL3	chr2	225346795	-
intron-3CDS	ENST00000472037	ENST00000344951	SCMH1	chr1	41707730	-	CUL3	chr2	225346795	-
intron-3CDS	ENST00000472037	ENST00000409096	SCMH1	chr1	41707731	-	CUL3	chr2	225343062	-
intron-3CDS	ENST00000472037	ENST00000409096	SCMH1	chr1	41707731	-	CUL3	chr2	225346795	-
intron-3CDS	ENST00000472037	ENST00000409096	SCMH1	chr1	41707730	-	CUL3	chr2	225346795	-
intron-3CDS	ENST00000472037	ENST00000409777	SCMH1	chr1	41707731	-	CUL3	chr2	225343062	-
intron-3CDS	ENST00000472037	ENST00000409777	SCMH1	chr1	41707731	-	CUL3	chr2	225346795	-
intron-3CDS	ENST00000472037	ENST00000409777	SCMH1	chr1	41707730	-	CUL3	chr2	225346795	-
intron-intron	ENST00000326197	ENST00000432260	SCMH1	chr1	41707731	-	CUL3	chr2	225343062	-
intron-intron	ENST00000326197	ENST00000432260	SCMH1	chr1	41707731	-	CUL3	chr2	225346795	-
intron-intron	ENST00000326197	ENST00000432260	SCMH1	chr1	41707730	-	CUL3	chr2	225346795	-
intron-intron	ENST00000361191	ENST00000432260	SCMH1	chr1	41707731	-	CUL3	chr2	225343062	-
intron-intron	ENST00000361191	ENST00000432260	SCMH1	chr1	41707731	-	CUL3	chr2	225346795	-
intron-intron	ENST00000361191	ENST00000432260	SCMH1	chr1	41707730	-	CUL3	chr2	225346795	-
intron-intron	ENST00000361705	ENST00000432260	SCMH1	chr1	41707731	-	CUL3	chr2	225343062	-
intron-intron	ENST00000361705	ENST00000432260	SCMH1	chr1	41707731	-	CUL3	chr2	225346795	-
intron-intron	ENST00000361705	ENST00000432260	SCMH1	chr1	41707730	-	CUL3	chr2	225346795	-
intron-intron	ENST00000372595	ENST00000432260	SCMH1	chr1	41707731	-	CUL3	chr2	225343062	-
intron-intron	ENST00000372595	ENST00000432260	SCMH1	chr1	41707731	-	CUL3	chr2	225346795	-
intron-intron	ENST00000372595	ENST00000432260	SCMH1	chr1	41707730	-	CUL3	chr2	225346795	-
intron-intron	ENST00000397171	ENST00000432260	SCMH1	chr1	41707731	-	CUL3	chr2	225343062	-
intron-intron	ENST00000397171	ENST00000432260	SCMH1	chr1	41707731	-	CUL3	chr2	225346795	-
intron-intron	ENST00000397171	ENST00000432260	SCMH1	chr1	41707730	-	CUL3	chr2	225346795	-
intron-intron	ENST00000397174	ENST00000432260	SCMH1	chr1	41707731	-	CUL3	chr2	225343062	-
intron-intron	ENST00000397174	ENST00000432260	SCMH1	chr1	41707731	-	CUL3	chr2	225346795	-
intron-intron	ENST00000397174	ENST00000432260	SCMH1	chr1	41707730	-	CUL3	chr2	225346795	-
intron-intron	ENST00000402904	ENST00000432260	SCMH1	chr1	41707731	-	CUL3	chr2	225343062	-
intron-intron	ENST00000402904	ENST00000432260	SCMH1	chr1	41707731	-	CUL3	chr2	225346795	-
intron-intron	ENST00000402904	ENST00000432260	SCMH1	chr1	41707730	-	CUL3	chr2	225346795	-
intron-intron	ENST00000456518	ENST00000432260	SCMH1	chr1	41707731	-	CUL3	chr2	225343062	-
intron-intron	ENST00000456518	ENST00000432260	SCMH1	chr1	41707731	-	CUL3	chr2	225346795	-
intron-intron	ENST00000456518	ENST00000432260	SCMH1	chr1	41707730	-	CUL3	chr2	225346795	-
intron-intron	ENST00000472037	ENST00000432260	SCMH1	chr1	41707731	-	CUL3	chr2	225343062	-
intron-intron	ENST00000472037	ENST00000432260	SCMH1	chr1	41707731	-	CUL3	chr2	225346795	-
intron-intron	ENST00000472037	ENST00000432260	SCMH1	chr1	41707730	-	CUL3	chr2	225346795	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

No-coding score

Coding score

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Fusion Genomic Features for SCMH1-CUL3

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for SCMH1-CUL3

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:41707731/:225343062)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	CUL3 Q13618
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Core component of multiple cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. BCR complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins (PubMed:27565346). As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1. The functional specificity of the BCR complex depends on the BTB domain-containing protein as the substrate recognition component. BCR(KLHL42) is involved in ubiquitination of KATNA1. BCR(SPOP) is involved in ubiquitination of BMI1/PCGF4, BRMS1, MACROH2A1 and DAXX, GLI2 and GLI3. Can also form a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex containing homodimeric SPOPL or the heterodimer formed by SPOP and SPOPL; these complexes have lower ubiquitin ligase activity. BCR(KLHL9-KLHL13) controls the dynamic behavior of AURKB on mitotic chromosomes and thereby coordinates faithful mitotic progression and completion of cytokinesis. BCR(KLHL12) is involved in ER-Golgi transport by regulating the size of COPII coats, thereby playing a key role in collagen export, which is required for embryonic stem (ES) cells division: BCR(KLHL12) acts by mediating monoubiquitination of SEC31 (SEC31A or SEC31B) (PubMed:22358839, PubMed:27716508). BCR(KLHL3) acts as a regulator of ion transport in the distal nephron; by mediating ubiquitination of WNK4 (PubMed:23387299, PubMed:23453970, PubMed:23576762). The BCR(KLHL20) E3 ubiquitin ligase complex is involved in interferon response and anterograde Golgi to endosome transport: it mediates both ubiquitination leading to degradation and 'Lys-33'-linked ubiquitination (PubMed:20389280, PubMed:21840486, PubMed:21670212, PubMed:24768539). The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of AURKB (PubMed:19995937). The BCR(KLHL22) ubiquitin ligase complex mediates monoubiquitination of PLK1, leading to PLK1 dissociation from phosphoreceptor proteins and subsequent removal from kinetochores, allowing silencing of the spindle assembly checkpoint (SAC) and chromosome segregation (PubMed:23455478). The BCR(KLHL22) ubiquitin ligase complex is also responsible for the amino acid-stimulated 'Lys-48' polyubiquitination and proteasomal degradation of DEPDC5. Through the degradation of DEPDC5, releases the GATOR1 complex-mediated inhibition of the TORC1 pathway (PubMed:29769719). The BCR(KLHL25) ubiquitin ligase complex is involved in translational homeostasis by mediating ubiquitination and subsequent degradation of hypophosphorylated EIF4EBP1 (4E-BP1) (PubMed:22578813). The BCR(KBTBD8) complex acts by mediating monoubiquitination of NOLC1 and TCOF1, leading to remodel the translational program of differentiating cells in favor of neural crest specification (PubMed:26399832). Involved in ubiquitination of cyclin E and of cyclin D1 (in vitro) thus involved in regulation of G1/S transition. Involved in the ubiquitination of KEAP1, ENC1 and KLHL41 (PubMed:15983046). In concert with ATF2 and RBX1, promotes degradation of KAT5 thereby attenuating its ability to acetylate and activate ATM. The BCR(KCTD17) E3 ubiquitin ligase complex mediates ubiquitination and degradation of TCHP, a down-regulator of cilium assembly, thereby inducing ciliogenesis (PubMed:25270598). The BCR(KLHL24) E3 ubiquitin ligase complex mediates ubiquitination of KRT14, controls KRT14 levels during keratinocytes differentiation, and is essential for skin integrity (PubMed:27798626). The BCR(KLHL18) E3 ubiquitin ligase complex mediates the ubiquitination of AURKA leading to its activation at the centrosome which is required for initiating mitotic entry (PubMed:23213400). The BCR(KEAP1) E3 ubiquitin ligase complex acts as a key sensor of oxidative and electrophilic stress by mediating ubiquitination and degradation of NFE2L2/NRF2, a transcription factor regulating expression of many cytoprotective genes (PubMed:15601839, PubMed:16006525). {ECO:0000269\|PubMed:10500095, ECO:0000269\|PubMed:11311237, ECO:0000269\|PubMed:15601839, ECO:0000269\|PubMed:15897469, ECO:0000269\|PubMed:15983046, ECO:0000269\|PubMed:16006525, ECO:0000269\|PubMed:16524876, ECO:0000269\|PubMed:17543862, ECO:0000269\|PubMed:18397884, ECO:0000269\|PubMed:19261606, ECO:0000269\|PubMed:19995937, ECO:0000269\|PubMed:20389280, ECO:0000269\|PubMed:21670212, ECO:0000269\|PubMed:21840486, ECO:0000269\|PubMed:22085717, ECO:0000269\|PubMed:22358839, ECO:0000269\|PubMed:22578813, ECO:0000269\|PubMed:22632832, ECO:0000269\|PubMed:23213400, ECO:0000269\|PubMed:23387299, ECO:0000269\|PubMed:23453970, ECO:0000269\|PubMed:23455478, ECO:0000269\|PubMed:23576762, ECO:0000269\|PubMed:24768539, ECO:0000269\|PubMed:25270598, ECO:0000269\|PubMed:26399832, ECO:0000269\|PubMed:27565346, ECO:0000269\|PubMed:27716508, ECO:0000269\|PubMed:27798626, ECO:0000269\|PubMed:29769719}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

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Fusion Gene Sequence for SCMH1-CUL3

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for SCMH1-CUL3

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for SCMH1-CUL3

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for SCMH1-CUL3

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source