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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:SCML2-PPHLN1 (FusionGDB2 ID:79669)

Fusion Gene Summary for SCML2-PPHLN1

check button Fusion gene summary
Fusion gene informationFusion gene name: SCML2-PPHLN1
Fusion gene ID: 79669
HgeneTgene
Gene symbol

SCML2

PPHLN1

Gene ID

10389

51535

Gene nameScm polycomb group protein like 2periphilin 1
Synonyms-CR|HSPC206|HSPC232
Cytomap

Xp22.13

12q12

Type of geneprotein-codingprotein-coding
Descriptionsex comb on midleg-like protein 2sex comb on midleg like 2periphilin-1CDC7 expression repressorgastric cancer antigen Ga50
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000251900, ENST00000398048, 
ENST00000491988, 		ENST00000550535, 
ENST00000317560, ENST00000337898, 
ENST00000358314, ENST00000395568, 
ENST00000432191, ENST00000449194, 
ENST00000552761, ENST00000256678, 
ENST00000395580, ENST00000549190, 
Fusion gene scores* DoF score5 X 6 X 2=6012 X 11 X 8=1056
# samples 613
** MAII scorelog2(6/60*10)=0log2(13/1056*10)=-3.02202630633
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SCML2 [Title/Abstract] AND PPHLN1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointSCML2(18278291)-PPHLN1(42729685), # samples:1
Anticipated loss of major functional domain due to fusion event.SCML2-PPHLN1 seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor due to the frame-shifted ORF.
SCML2-PPHLN1 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
SCML2-PPHLN1 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgenePPHLN1

GO:0045814

negative regulation of gene expression, epigenetic

26022416|28581500

TgenePPHLN1

GO:0090309

positive regulation of methylation-dependent chromatin silencing

28581500

TgenePPHLN1

GO:0097355

protein localization to heterochromatin

28581500


check buttonFusion gene breakpoints across SCML2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across PPHLN1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-E2-A14T-01ASCML2chrX

18278291

-PPHLN1chr12

42729685

+


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Fusion Gene ORF analysis for SCML2-PPHLN1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000251900ENST00000550535SCML2chrX

18278291

-PPHLN1chr12

42729685

+
5CDS-3UTRENST00000398048ENST00000550535SCML2chrX

18278291

-PPHLN1chr12

42729685

+
5CDS-5UTRENST00000251900ENST00000317560SCML2chrX

18278291

-PPHLN1chr12

42729685

+
5CDS-5UTRENST00000251900ENST00000337898SCML2chrX

18278291

-PPHLN1chr12

42729685

+
5CDS-5UTRENST00000251900ENST00000358314SCML2chrX

18278291

-PPHLN1chr12

42729685

+
5CDS-5UTRENST00000251900ENST00000395568SCML2chrX

18278291

-PPHLN1chr12

42729685

+
5CDS-5UTRENST00000251900ENST00000432191SCML2chrX

18278291

-PPHLN1chr12

42729685

+
5CDS-5UTRENST00000251900ENST00000449194SCML2chrX

18278291

-PPHLN1chr12

42729685

+
5CDS-5UTRENST00000251900ENST00000552761SCML2chrX

18278291

-PPHLN1chr12

42729685

+
5CDS-5UTRENST00000398048ENST00000317560SCML2chrX

18278291

-PPHLN1chr12

42729685

+
5CDS-5UTRENST00000398048ENST00000337898SCML2chrX

18278291

-PPHLN1chr12

42729685

+
5CDS-5UTRENST00000398048ENST00000358314SCML2chrX

18278291

-PPHLN1chr12

42729685

+
5CDS-5UTRENST00000398048ENST00000395568SCML2chrX

18278291

-PPHLN1chr12

42729685

+
5CDS-5UTRENST00000398048ENST00000432191SCML2chrX

18278291

-PPHLN1chr12

42729685

+
5CDS-5UTRENST00000398048ENST00000449194SCML2chrX

18278291

-PPHLN1chr12

42729685

+
5CDS-5UTRENST00000398048ENST00000552761SCML2chrX

18278291

-PPHLN1chr12

42729685

+
5CDS-intronENST00000251900ENST00000256678SCML2chrX

18278291

-PPHLN1chr12

42729685

+
5CDS-intronENST00000398048ENST00000256678SCML2chrX

18278291

-PPHLN1chr12

42729685

+
Frame-shiftENST00000398048ENST00000395580SCML2chrX

18278291

-PPHLN1chr12

42729685

+
Frame-shiftENST00000398048ENST00000549190SCML2chrX

18278291

-PPHLN1chr12

42729685

+
In-frameENST00000251900ENST00000395580SCML2chrX

18278291

-PPHLN1chr12

42729685

+
In-frameENST00000251900ENST00000549190SCML2chrX

18278291

-PPHLN1chr12

42729685

+
intron-3CDSENST00000491988ENST00000395580SCML2chrX

18278291

-PPHLN1chr12

42729685

+
intron-3CDSENST00000491988ENST00000549190SCML2chrX

18278291

-PPHLN1chr12

42729685

+
intron-3UTRENST00000491988ENST00000550535SCML2chrX

18278291

-PPHLN1chr12

42729685

+
intron-5UTRENST00000491988ENST00000317560SCML2chrX

18278291

-PPHLN1chr12

42729685

+
intron-5UTRENST00000491988ENST00000337898SCML2chrX

18278291

-PPHLN1chr12

42729685

+
intron-5UTRENST00000491988ENST00000358314SCML2chrX

18278291

-PPHLN1chr12

42729685

+
intron-5UTRENST00000491988ENST00000395568SCML2chrX

18278291

-PPHLN1chr12

42729685

+
intron-5UTRENST00000491988ENST00000432191SCML2chrX

18278291

-PPHLN1chr12

42729685

+
intron-5UTRENST00000491988ENST00000449194SCML2chrX

18278291

-PPHLN1chr12

42729685

+
intron-5UTRENST00000491988ENST00000552761SCML2chrX

18278291

-PPHLN1chr12

42729685

+
intron-intronENST00000491988ENST00000256678SCML2chrX

18278291

-PPHLN1chr12

42729685

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000251900SCML2chrX18278291-ENST00000549190PPHLN1chr1242729685+279112291122352746
ENST00000251900SCML2chrX18278291-ENST00000395580PPHLN1chr1242729685+279412291122352746

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000251900ENST00000549190SCML2chrX18278291-PPHLN1chr1242729685+0.0008052670.9991947
ENST00000251900ENST00000395580SCML2chrX18278291-PPHLN1chr1242729685+0.0007869690.999213

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Fusion Genomic Features for SCML2-PPHLN1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
SCML2chrX18278290-PPHLN1chr1242729684+1.84E-060.9999982
SCML2chrX18278290-PPHLN1chr1242729684+1.84E-060.9999982

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for SCML2-PPHLN1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chrX:18278291/chr12:42729685)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSCML2chrX:18278291chr12:42729685ENST00000251900-915139_240356701.0RepeatNote=MBT 2
HgeneSCML2chrX:18278291chr12:42729685ENST00000251900-91533_131356701.0RepeatNote=MBT 1
TgenePPHLN1chrX:18278291chr12:42729685ENST00000358314010140_2150368.0Compositional biasNote=Ser-rich
TgenePPHLN1chrX:18278291chr12:42729685ENST00000395568013140_2150459.0Compositional biasNote=Ser-rich
TgenePPHLN1chrX:18278291chr12:42729685ENST00000395580111140_2150375.0Compositional biasNote=Ser-rich
TgenePPHLN1chrX:18278291chr12:42729685ENST00000432191012140_2150435.0Compositional biasNote=Ser-rich
TgenePPHLN1chrX:18278291chr12:42729685ENST00000552761110140_2150320.0Compositional biasNote=Ser-rich
TgenePPHLN1chrX:18278291chr12:42729685ENST00000358314010103_1090368.0MotifNuclear localization signal
TgenePPHLN1chrX:18278291chr12:42729685ENST00000395568013103_1090459.0MotifNuclear localization signal
TgenePPHLN1chrX:18278291chr12:42729685ENST00000395580111103_1090375.0MotifNuclear localization signal
TgenePPHLN1chrX:18278291chr12:42729685ENST00000432191012103_1090435.0MotifNuclear localization signal
TgenePPHLN1chrX:18278291chr12:42729685ENST00000552761110103_1090320.0MotifNuclear localization signal

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSCML2chrX:18278291chr12:42729685ENST00000251900-915631_700356701.0DomainNote=SAM


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Fusion Gene Sequence for SCML2-PPHLN1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>79669_79669_1_SCML2-PPHLN1_SCML2_chrX_18278291_ENST00000251900_PPHLN1_chr12_42729685_ENST00000395580_length(transcript)=2794nt_BP=1229nt
GGCGGCAGTGGCGGTTGCGGGGCATGCGCGGCTCCGCGCGCGGCTTCTCAAACATGGCGGCGGCGGTGTGAAGCTCGGTGCCGGCTCGCG
CGATCGGTGGGACAGAATTTCGTTGTTTTCACCGACGAGACTGGAGGAAACAACACCAAATAGGGATACCATGGGACAAACAGTGAATGA
AGATTCCATGGATGTCAAGAAGGAGAATCAAGAGAAAACTCCTCAGTCAAGTACATCTTCTGTACAAAGGGATGATTTCCACTGGGAGGA
GTATTTGAAAGAGACTGGGTCTATAAGTGCTCCTTCAGAGTGCTTCCGTCAGTCTCAGATTCCACCTGTGAATGATTTCAAAGTTGGTAT
GAAATTGGAAGCCCGTGACCCTCGCAATGCCACTTCAGTATGTATTGCTACGGTTATTGGAATTACTGGGGCCAGGTTACGGTTACGACT
GGATGGTAGTGACAACAGAAATGATTTTTGGAGGCTTGTCGATTCCCCAGACATACAACCTGTTGGGACATGTGAAAAGGAAGGAGACTT
ACTTCAACCTCCACTAGGGTACCAGATGAATACATCCTCCTGGCCGATGTTCCTCTTAAAGACACTAAATGGGTCTGAAATGGCATCTGC
CACATTATTTAAGAAGGAACCACCAAAGCCCCCACTAAATAATTTTAAAGTGGGGATGAAACTGGAAGCTATTGACAAAAAGAACCCGTA
TCTCATCTGTCCTGCGACCATTGGAGATGTTAAAGGGGATGAAGTTCATATCACATTTGATGGCTGGAGTGGAGCTTTTGATTACTGGTG
CAAGTATGATTCTCGAGATATTTTCCCAGCTGGGTGGTGTCGCCTGACAGGAGATGTATTACAACCCCCAGGAACTAGTGTTCCTATTGT
AAAGAATATAGCAAAAACAGAGTCTTCTCCTTCCGAAGCAAGCCAGCATTCAATGCAGTCTCCACAGAAAACTACTCTAATATTACCAAC
ACAGCAGGTCAGGAGATCAAGTCGAATTAAACCACCTGGACCTACTGCAGTCCCCAAAAGGAGCAGTTCTGTTAAAAATATCACACCAAG
GAAAAAAGGTCCAAACTCAGGAAAAAAGGAAAAACCTTTGCCCGTGATATGTTCTACATCTGCAGCTTCTCTAAAATCGCTGACCAGAGA
CCGTGGCATGTTATATAAAGATGTCGCTTCTGGGCCATGTAAAATAGTGATGTCTACAGTGGCTTACAGAAGAGACGAAATGTGGTCTGA
GGGACGATATGAATATGAAAGAATTCCGAGAGAACGAGCACCTCCTCGAAGTCATCCCAGTGATGGCTACAATAGACTAGTTAATATTGT
GCCAAAGAAACCACCACTGCTAGACAGACCTGGTGAAGGAAGCTACAATAGATATTACAGTCATGTTGATTACCGAGACTATGACGAGGG
CCGCAGTTTTTCTCATGATCGAAGAAGTGGTCCACCTCACAGAGGAGATGAATCTGGTTATAGATGGACAAGAGACGATCATTCTGCAAG
CAGGCAACCTGAATACAGGGACATGAGAGATGGCTTTAGAAGAAAAAGTTTCTACTCTTCCCATTATGCGAGAGAGCGGTCTCCTTATAA
AAGGGACAATACTTTTTTCAGAGAATCACCTGTTGGCCGAAAGGATTCTCCACACAGCAGATCTGGTTCCAGTGTCAGTAGCAGAAGCTA
CTCTCCAGAAAGGAGCAAATCATACTCTTTCCATCAGTCTCAACATAGAAAGTCCGTGCGTCCTGGTGCCTCCTACAAACGGCAGAATGA
AGGAAATCCTGAAAGAGATAAAGAGAGGCCTGTCCAGTCTTTGAAAACATCAAGAGATACTTCACCCTCAAGTGGTTCAGCAGTTTCTTC
ATCAAAGGTGTTAGACAAACCCAGTAGGCTAACTGAAAAGGAACTTGCTGAGGCTGCAAGCAAGTGGGCTGCTGAAAAGCTAGAGAAATC
AGATGAAAGTAACTTGCCTGAAATTTCTGAGTATGAGGCGGGATCCACAGCACCATTGTTTACTGACCAGCCAGAGGAACCTGAGTCAAA
CACAACACATGGGATAGAATTATTTGAAGATAGTCAGCTAACCACTCGCTCTAAAGCAATAGCATCAAAAACCAAAGAGATTGAACAGGT
TTACCGACAAGACTGTGAAACTTTCGGGATGGTGGTGAAAATGCTGATTGAAAAAGATCCTTCATTAGAAAAGTCTATACAGTTTGCATT
GAGGCAGAATTTACATGAAATAGGTGAGCGGTGTGTTGAAGAACTCAAGCATTTCATTGCAGAGTATGATACTTCCACTCAAGATTTTGG
AGAGCCTTTTTAGATTTTTCTGCTCAGGCTAAAAAAAAAAAAAAACAGTTTCTAAAAATTTTTTTTCCTGGATTGTGTAAATCCTTAATA
TATGGAATTTTTGTGATGCAGAGAAATACTTTATGATAGTTGACAACATTTCAGTATTAAATAAACATCTAAAATAGTCTGTTTAAAATG
TTTGATTCAAATTTTTGTATTTTTTGTAGAGATGGGGTTCACCATGTTGGCCAGGCTAGTCTCTAACTCCTGGCCTCAAGTGATCTGCCT
GCCTCAGCCTCTCAAAGTGTTGAGATTACAGGCGTGAGCCACCGCTCCCTGCCCAACACATATACCATCTGAAAATGTTAGAATTCTGAG
TTGTGATTTTATTGACTTGTTGCTTGCTTTTTCTTAGGCTTTGTAACTTGTAATATGTTAAAGTGTACTATCCTAATAAACTGAATACTT

>79669_79669_1_SCML2-PPHLN1_SCML2_chrX_18278291_ENST00000251900_PPHLN1_chr12_42729685_ENST00000395580_length(amino acids)=746AA_BP=370
MFSPTRLEETTPNRDTMGQTVNEDSMDVKKENQEKTPQSSTSSVQRDDFHWEEYLKETGSISAPSECFRQSQIPPVNDFKVGMKLEARDP
RNATSVCIATVIGITGARLRLRLDGSDNRNDFWRLVDSPDIQPVGTCEKEGDLLQPPLGYQMNTSSWPMFLLKTLNGSEMASATLFKKEP
PKPPLNNFKVGMKLEAIDKKNPYLICPATIGDVKGDEVHITFDGWSGAFDYWCKYDSRDIFPAGWCRLTGDVLQPPGTSVPIVKNIAKTE
SSPSEASQHSMQSPQKTTLILPTQQVRRSSRIKPPGPTAVPKRSSSVKNITPRKKGPNSGKKEKPLPVICSTSAASLKSLTRDRGMLYKD
VASGPCKIVMSTVAYRRDEMWSEGRYEYERIPRERAPPRSHPSDGYNRLVNIVPKKPPLLDRPGEGSYNRYYSHVDYRDYDEGRSFSHDR
RSGPPHRGDESGYRWTRDDHSASRQPEYRDMRDGFRRKSFYSSHYARERSPYKRDNTFFRESPVGRKDSPHSRSGSSVSSRSYSPERSKS
YSFHQSQHRKSVRPGASYKRQNEGNPERDKERPVQSLKTSRDTSPSSGSAVSSSKVLDKPSRLTEKELAEAASKWAAEKLEKSDESNLPE
ISEYEAGSTAPLFTDQPEEPESNTTHGIELFEDSQLTTRSKAIASKTKEIEQVYRQDCETFGMVVKMLIEKDPSLEKSIQFALRQNLHEI

--------------------------------------------------------------
>79669_79669_2_SCML2-PPHLN1_SCML2_chrX_18278291_ENST00000251900_PPHLN1_chr12_42729685_ENST00000549190_length(transcript)=2791nt_BP=1229nt
GGCGGCAGTGGCGGTTGCGGGGCATGCGCGGCTCCGCGCGCGGCTTCTCAAACATGGCGGCGGCGGTGTGAAGCTCGGTGCCGGCTCGCG
CGATCGGTGGGACAGAATTTCGTTGTTTTCACCGACGAGACTGGAGGAAACAACACCAAATAGGGATACCATGGGACAAACAGTGAATGA
AGATTCCATGGATGTCAAGAAGGAGAATCAAGAGAAAACTCCTCAGTCAAGTACATCTTCTGTACAAAGGGATGATTTCCACTGGGAGGA
GTATTTGAAAGAGACTGGGTCTATAAGTGCTCCTTCAGAGTGCTTCCGTCAGTCTCAGATTCCACCTGTGAATGATTTCAAAGTTGGTAT
GAAATTGGAAGCCCGTGACCCTCGCAATGCCACTTCAGTATGTATTGCTACGGTTATTGGAATTACTGGGGCCAGGTTACGGTTACGACT
GGATGGTAGTGACAACAGAAATGATTTTTGGAGGCTTGTCGATTCCCCAGACATACAACCTGTTGGGACATGTGAAAAGGAAGGAGACTT
ACTTCAACCTCCACTAGGGTACCAGATGAATACATCCTCCTGGCCGATGTTCCTCTTAAAGACACTAAATGGGTCTGAAATGGCATCTGC
CACATTATTTAAGAAGGAACCACCAAAGCCCCCACTAAATAATTTTAAAGTGGGGATGAAACTGGAAGCTATTGACAAAAAGAACCCGTA
TCTCATCTGTCCTGCGACCATTGGAGATGTTAAAGGGGATGAAGTTCATATCACATTTGATGGCTGGAGTGGAGCTTTTGATTACTGGTG
CAAGTATGATTCTCGAGATATTTTCCCAGCTGGGTGGTGTCGCCTGACAGGAGATGTATTACAACCCCCAGGAACTAGTGTTCCTATTGT
AAAGAATATAGCAAAAACAGAGTCTTCTCCTTCCGAAGCAAGCCAGCATTCAATGCAGTCTCCACAGAAAACTACTCTAATATTACCAAC
ACAGCAGGTCAGGAGATCAAGTCGAATTAAACCACCTGGACCTACTGCAGTCCCCAAAAGGAGCAGTTCTGTTAAAAATATCACACCAAG
GAAAAAAGGTCCAAACTCAGGAAAAAAGGAAAAACCTTTGCCCGTGATATGTTCTACATCTGCAGCTTCTCTAAAATCGCTGACCAGAGA
CCGTGGCATGTTATATAAAGATGTCGCTTCTGGGCCATGTAAAATAGTGATGTCTACAGTGGCTTACAGAAGAGACGAAATGTGGTCTGA
GGGACGATATGAATATGAAAGAATTCCGAGAGAACGAGCACCTCCTCGAAGTCATCCCAGTGATGGCTACAATAGACTAGTTAATATTGT
GCCAAAGAAACCACCACTGCTAGACAGACCTGGTGAAGGAAGCTACAATAGATATTACAGTCATGTTGATTACCGAGACTATGACGAGGG
CCGCAGTTTTTCTCATGATCGAAGAAGTGGTCCACCTCACAGAGGAGATGAATCTGGTTATAGATGGACAAGAGACGATCATTCTGCAAG
CAGGCAACCTGAATACAGGGACATGAGAGATGGCTTTAGAAGAAAAAGTTTCTACTCTTCCCATTATGCGAGAGAGCGGTCTCCTTATAA
AAGGGACAATACTTTTTTCAGAGAATCACCTGTTGGCCGAAAGGATTCTCCACACAGCAGATCTGGTTCCAGTGTCAGTAGCAGAAGCTA
CTCTCCAGAAAGGAGCAAATCATACTCTTTCCATCAGTCTCAACATAGAAAGTCCGTGCGTCCTGGTGCCTCCTACAAACGGCAGAATGA
AGGAAATCCTGAAAGAGATAAAGAGAGGCCTGTCCAGTCTTTGAAAACATCAAGAGATACTTCACCCTCAAGTGGTTCAGCAGTTTCTTC
ATCAAAGGTGTTAGACAAACCCAGTAGGCTAACTGAAAAGGAACTTGCTGAGGCTGCAAGCAAGTGGGCTGCTGAAAAGCTAGAGAAATC
AGATGAAAGTAACTTGCCTGAAATTTCTGAGTATGAGGCGGGATCCACAGCACCATTGTTTACTGACCAGCCAGAGGAACCTGAGTCAAA
CACAACACATGGGATAGAATTATTTGAAGATAGTCAGCTAACCACTCGCTCTAAAGCAATAGCATCAAAAACCAAAGAGATTGAACAGGT
TTACCGACAAGACTGTGAAACTTTCGGGATGGTGGTGAAAATGCTGATTGAAAAAGATCCTTCATTAGAAAAGTCTATACAGTTTGCATT
GAGGCAGAATTTACATGAAATAGGTGAGCGGTGTGTTGAAGAACTCAAGCATTTCATTGCAGAGTATGATACTTCCACTCAAGATTTTGG
AGAGCCTTTTTAGATTTTTCTGCTCAGGCTAAAAAAAAAAAAAAACAGTTTCTAAAAATTTTTTTTCCTGGATTGTGTAAATCCTTAATA
TATGGAATTTTTGTGATGCAGAGAAATACTTTATGATAGTTGACAACATTTCAGTATTAAATAAACATCTAAAATAGTCTGTTTAAAATG
TTTGATTCAAATTTTTGTATTTTTTGTAGAGATGGGGTTCACCATGTTGGCCAGGCTAGTCTCTAACTCCTGGCCTCAAGTGATCTGCCT
GCCTCAGCCTCTCAAAGTGTTGAGATTACAGGCGTGAGCCACCGCTCCCTGCCCAACACATATACCATCTGAAAATGTTAGAATTCTGAG
TTGTGATTTTATTGACTTGTTGCTTGCTTTTTCTTAGGCTTTGTAACTTGTAATATGTTAAAGTGTACTATCCTAATAAACTGAATACTT

>79669_79669_2_SCML2-PPHLN1_SCML2_chrX_18278291_ENST00000251900_PPHLN1_chr12_42729685_ENST00000549190_length(amino acids)=746AA_BP=370
MFSPTRLEETTPNRDTMGQTVNEDSMDVKKENQEKTPQSSTSSVQRDDFHWEEYLKETGSISAPSECFRQSQIPPVNDFKVGMKLEARDP
RNATSVCIATVIGITGARLRLRLDGSDNRNDFWRLVDSPDIQPVGTCEKEGDLLQPPLGYQMNTSSWPMFLLKTLNGSEMASATLFKKEP
PKPPLNNFKVGMKLEAIDKKNPYLICPATIGDVKGDEVHITFDGWSGAFDYWCKYDSRDIFPAGWCRLTGDVLQPPGTSVPIVKNIAKTE
SSPSEASQHSMQSPQKTTLILPTQQVRRSSRIKPPGPTAVPKRSSSVKNITPRKKGPNSGKKEKPLPVICSTSAASLKSLTRDRGMLYKD
VASGPCKIVMSTVAYRRDEMWSEGRYEYERIPRERAPPRSHPSDGYNRLVNIVPKKPPLLDRPGEGSYNRYYSHVDYRDYDEGRSFSHDR
RSGPPHRGDESGYRWTRDDHSASRQPEYRDMRDGFRRKSFYSSHYARERSPYKRDNTFFRESPVGRKDSPHSRSGSSVSSRSYSPERSKS
YSFHQSQHRKSVRPGASYKRQNEGNPERDKERPVQSLKTSRDTSPSSGSAVSSSKVLDKPSRLTEKELAEAASKWAAEKLEKSDESNLPE
ISEYEAGSTAPLFTDQPEEPESNTTHGIELFEDSQLTTRSKAIASKTKEIEQVYRQDCETFGMVVKMLIEKDPSLEKSIQFALRQNLHEI

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Fusion Gene PPI Analysis for SCML2-PPHLN1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for SCML2-PPHLN1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for SCML2-PPHLN1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource