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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:SCNN1A-DCP1B (FusionGDB2 ID:79707)

Fusion Gene Summary for SCNN1A-DCP1B

check button Fusion gene summary
Fusion gene informationFusion gene name: SCNN1A-DCP1B
Fusion gene ID: 79707
HgeneTgene
Gene symbol

SCNN1A

DCP1B

Gene ID

6337

196513

Gene namesodium channel epithelial 1 subunit alphadecapping mRNA 1B
SynonymsBESC2|ENaCa|ENaCalpha|LIDLS3|SCNEA|SCNN1DCP1
Cytomap

12p13.31

12p13.33

Type of geneprotein-codingprotein-coding
Descriptionamiloride-sensitive sodium channel subunit alphaalpha ENaC-2alpha-ENaCalpha-NaCHamiloride-sensitive epithelial sodium channel alpha subunitamiloride-sensitive sodium channel subunit alpha 2epithelial Na(+) channel subunit alphanasal epithelial sodimRNA-decapping enzyme 1BDCP1 decapping enzyme homolog Bdecapping enzyme hDcp1b
Modification date2020031320200328
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000396966, ENST00000228916, 
ENST00000358945, ENST00000360168, 
ENST00000540037, ENST00000543768, 
ENST00000538979, 		ENST00000280665, 
ENST00000397173, ENST00000540622, 
ENST00000541700, 
Fusion gene scores* DoF score3 X 4 X 3=365 X 4 X 5=100
# samples 67
** MAII scorelog2(6/36*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(7/100*10)=-0.514573172829758
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SCNN1A [Title/Abstract] AND DCP1B [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointSCNN1A(6457893)-DCP1B(2055452), # samples:3
Anticipated loss of major functional domain due to fusion event.SCNN1A-DCP1B seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
SCNN1A-DCP1B seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneSCNN1A

GO:0035725

sodium ion transmembrane transport

24124190

HgeneSCNN1A

GO:0050891

multicellular organismal water homeostasis

24124190

HgeneSCNN1A

GO:0055078

sodium ion homeostasis

24124190


check buttonFusion gene breakpoints across SCNN1A (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across DCP1B (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4HNSCTCGA-BA-6871-01ASCNN1Achr12

6457893

-DCP1Bchr12

2055452

-
ChimerDB4HNSCTCGA-BA-6871SCNN1Achr12

6457237

-DCP1Bchr12

2055452

-
ChimerDB4HNSCTCGA-BA-6871SCNN1Achr12

6457893

-DCP1Bchr12

2055452

-


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Fusion Gene ORF analysis for SCNN1A-DCP1B

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000396966ENST00000280665SCNN1Achr12

6457893

-DCP1Bchr12

2055452

-
3UTR-3CDSENST00000396966ENST00000397173SCNN1Achr12

6457893

-DCP1Bchr12

2055452

-
3UTR-intronENST00000396966ENST00000540622SCNN1Achr12

6457893

-DCP1Bchr12

2055452

-
3UTR-intronENST00000396966ENST00000541700SCNN1Achr12

6457893

-DCP1Bchr12

2055452

-
5CDS-intronENST00000228916ENST00000540622SCNN1Achr12

6457893

-DCP1Bchr12

2055452

-
5CDS-intronENST00000228916ENST00000541700SCNN1Achr12

6457893

-DCP1Bchr12

2055452

-
5CDS-intronENST00000358945ENST00000540622SCNN1Achr12

6457893

-DCP1Bchr12

2055452

-
5CDS-intronENST00000358945ENST00000541700SCNN1Achr12

6457893

-DCP1Bchr12

2055452

-
5CDS-intronENST00000360168ENST00000540622SCNN1Achr12

6457893

-DCP1Bchr12

2055452

-
5CDS-intronENST00000360168ENST00000541700SCNN1Achr12

6457893

-DCP1Bchr12

2055452

-
5CDS-intronENST00000540037ENST00000540622SCNN1Achr12

6457893

-DCP1Bchr12

2055452

-
5CDS-intronENST00000540037ENST00000541700SCNN1Achr12

6457893

-DCP1Bchr12

2055452

-
5CDS-intronENST00000543768ENST00000540622SCNN1Achr12

6457893

-DCP1Bchr12

2055452

-
5CDS-intronENST00000543768ENST00000541700SCNN1Achr12

6457893

-DCP1Bchr12

2055452

-
Frame-shiftENST00000228916ENST00000397173SCNN1Achr12

6457893

-DCP1Bchr12

2055452

-
Frame-shiftENST00000358945ENST00000280665SCNN1Achr12

6457893

-DCP1Bchr12

2055452

-
Frame-shiftENST00000358945ENST00000397173SCNN1Achr12

6457893

-DCP1Bchr12

2055452

-
Frame-shiftENST00000360168ENST00000280665SCNN1Achr12

6457893

-DCP1Bchr12

2055452

-
Frame-shiftENST00000360168ENST00000397173SCNN1Achr12

6457893

-DCP1Bchr12

2055452

-
Frame-shiftENST00000540037ENST00000280665SCNN1Achr12

6457893

-DCP1Bchr12

2055452

-
Frame-shiftENST00000543768ENST00000280665SCNN1Achr12

6457893

-DCP1Bchr12

2055452

-
Frame-shiftENST00000543768ENST00000397173SCNN1Achr12

6457893

-DCP1Bchr12

2055452

-
In-frameENST00000228916ENST00000280665SCNN1Achr12

6457893

-DCP1Bchr12

2055452

-
In-frameENST00000540037ENST00000397173SCNN1Achr12

6457893

-DCP1Bchr12

2055452

-
intron-3CDSENST00000228916ENST00000280665SCNN1Achr12

6457237

-DCP1Bchr12

2055452

-
intron-3CDSENST00000228916ENST00000397173SCNN1Achr12

6457237

-DCP1Bchr12

2055452

-
intron-3CDSENST00000358945ENST00000280665SCNN1Achr12

6457237

-DCP1Bchr12

2055452

-
intron-3CDSENST00000358945ENST00000397173SCNN1Achr12

6457237

-DCP1Bchr12

2055452

-
intron-3CDSENST00000360168ENST00000280665SCNN1Achr12

6457237

-DCP1Bchr12

2055452

-
intron-3CDSENST00000360168ENST00000397173SCNN1Achr12

6457237

-DCP1Bchr12

2055452

-
intron-3CDSENST00000396966ENST00000280665SCNN1Achr12

6457237

-DCP1Bchr12

2055452

-
intron-3CDSENST00000396966ENST00000397173SCNN1Achr12

6457237

-DCP1Bchr12

2055452

-
intron-3CDSENST00000538979ENST00000280665SCNN1Achr12

6457893

-DCP1Bchr12

2055452

-
intron-3CDSENST00000538979ENST00000280665SCNN1Achr12

6457237

-DCP1Bchr12

2055452

-
intron-3CDSENST00000538979ENST00000397173SCNN1Achr12

6457893

-DCP1Bchr12

2055452

-
intron-3CDSENST00000538979ENST00000397173SCNN1Achr12

6457237

-DCP1Bchr12

2055452

-
intron-3CDSENST00000540037ENST00000280665SCNN1Achr12

6457237

-DCP1Bchr12

2055452

-
intron-3CDSENST00000540037ENST00000397173SCNN1Achr12

6457237

-DCP1Bchr12

2055452

-
intron-3CDSENST00000543768ENST00000280665SCNN1Achr12

6457237

-DCP1Bchr12

2055452

-
intron-3CDSENST00000543768ENST00000397173SCNN1Achr12

6457237

-DCP1Bchr12

2055452

-
intron-intronENST00000228916ENST00000540622SCNN1Achr12

6457237

-DCP1Bchr12

2055452

-
intron-intronENST00000228916ENST00000541700SCNN1Achr12

6457237

-DCP1Bchr12

2055452

-
intron-intronENST00000358945ENST00000540622SCNN1Achr12

6457237

-DCP1Bchr12

2055452

-
intron-intronENST00000358945ENST00000541700SCNN1Achr12

6457237

-DCP1Bchr12

2055452

-
intron-intronENST00000360168ENST00000540622SCNN1Achr12

6457237

-DCP1Bchr12

2055452

-
intron-intronENST00000360168ENST00000541700SCNN1Achr12

6457237

-DCP1Bchr12

2055452

-
intron-intronENST00000396966ENST00000540622SCNN1Achr12

6457237

-DCP1Bchr12

2055452

-
intron-intronENST00000396966ENST00000541700SCNN1Achr12

6457237

-DCP1Bchr12

2055452

-
intron-intronENST00000538979ENST00000540622SCNN1Achr12

6457893

-DCP1Bchr12

2055452

-
intron-intronENST00000538979ENST00000540622SCNN1Achr12

6457237

-DCP1Bchr12

2055452

-
intron-intronENST00000538979ENST00000541700SCNN1Achr12

6457893

-DCP1Bchr12

2055452

-
intron-intronENST00000538979ENST00000541700SCNN1Achr12

6457237

-DCP1Bchr12

2055452

-
intron-intronENST00000540037ENST00000540622SCNN1Achr12

6457237

-DCP1Bchr12

2055452

-
intron-intronENST00000540037ENST00000541700SCNN1Achr12

6457237

-DCP1Bchr12

2055452

-
intron-intronENST00000543768ENST00000540622SCNN1Achr12

6457237

-DCP1Bchr12

2055452

-
intron-intronENST00000543768ENST00000541700SCNN1Achr12

6457237

-DCP1Bchr12

2055452

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000540037SCNN1Achr126457893-ENST00000397173DCP1Bchr122055452-176816339041713269
ENST00000228916SCNN1Achr126457893-ENST00000280665DCP1Bchr122055452-19611728541808584

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000540037ENST00000397173SCNN1Achr126457893-DCP1Bchr122055452-0.0043842260.9956157
ENST00000228916ENST00000280665SCNN1Achr126457893-DCP1Bchr122055452-0.0045626360.9954373

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Fusion Genomic Features for SCNN1A-DCP1B


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for SCNN1A-DCP1B


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:6457893/chr12:2055452)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSCNN1Achr12:6457893chr12:2055452ENST00000228916-12131_85543670.0Topological domainCytoplasmic
HgeneSCNN1Achr12:6457893chr12:2055452ENST00000360168-1112107_562602729.0Topological domainExtracellular
HgeneSCNN1Achr12:6457893chr12:2055452ENST00000360168-11121_85602729.0Topological domainCytoplasmic
HgeneSCNN1Achr12:6457893chr12:2055452ENST00000543768-1213107_562566693.0Topological domainExtracellular
HgeneSCNN1Achr12:6457893chr12:2055452ENST00000543768-12131_85566693.0Topological domainCytoplasmic
HgeneSCNN1Achr12:6457893chr12:2055452ENST00000228916-121386_106543670.0TransmembraneHelical%3B Name%3D1
HgeneSCNN1Achr12:6457893chr12:2055452ENST00000360168-1112563_583602729.0TransmembraneHelical%3B Name%3D2
HgeneSCNN1Achr12:6457893chr12:2055452ENST00000360168-111286_106602729.0TransmembraneHelical%3B Name%3D1
HgeneSCNN1Achr12:6457893chr12:2055452ENST00000543768-121386_106566693.0TransmembraneHelical%3B Name%3D1

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSCNN1Achr12:6457893chr12:2055452ENST00000228916-1213107_562543670.0Topological domainExtracellular
HgeneSCNN1Achr12:6457893chr12:2055452ENST00000228916-1213584_669543670.0Topological domainCytoplasmic
HgeneSCNN1Achr12:6457893chr12:2055452ENST00000360168-1112584_669602729.0Topological domainCytoplasmic
HgeneSCNN1Achr12:6457893chr12:2055452ENST00000543768-1213584_669566693.0Topological domainCytoplasmic
HgeneSCNN1Achr12:6457893chr12:2055452ENST00000228916-1213563_583543670.0TransmembraneHelical%3B Name%3D2
HgeneSCNN1Achr12:6457893chr12:2055452ENST00000543768-1213563_583566693.0TransmembraneHelical%3B Name%3D2
TgeneDCP1Bchr12:6457893chr12:2055452ENST0000028066579252_261591618.0Compositional biasNote=Poly-Gln


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Fusion Gene Sequence for SCNN1A-DCP1B


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>79707_79707_1_SCNN1A-DCP1B_SCNN1A_chr12_6457893_ENST00000228916_DCP1B_chr12_2055452_ENST00000280665_length(transcript)=1961nt_BP=1728nt
CCGGCCAGCGGGCGGGCTCCCCAGCCAGGCCGCTGCACCTGTCAGGGGAACAAGCTGGAGGAGCAGGACCCTAGACCTCTGCAGCCCATA
CCAGGTCTCATGGAGGGGAACAAGCTGGAGGAGCAGGACTCTAGCCCTCCACAGTCCACTCCAGGGCTCATGAAGGGGAACAAGCGTGAG
GAGCAGGGGCTGGGCCCCGAACCTGCGGCGCCCCAGCAGCCCACGGCGGAGGAGGAGGCCCTGATCGAGTTCCACCGCTCCTACCGAGAG
CTCTTCGAGTTCTTCTGCAACAACACCACCATCCACGGCGCCATCCGCCTGGTGTGCTCCCAGCACAACCGCATGAAGACGGCCTTCTGG
GCAGTGCTGTGGCTCTGCACCTTTGGCATGATGTACTGGCAATTCGGCCTGCTTTTCGGAGAGTACTTCAGCTACCCCGTCAGCCTCAAC
ATCAACCTCAACTCGGACAAGCTCGTCTTCCCCGCAGTGACCATCTGCACCCTCAATCCCTACAGGTACCCGGAAATTAAAGAGGAGCTG
GAGGAGCTGGACCGCATCACAGAGCAGACGCTCTTTGACCTGTACAAATACAGCTCCTTCACCACTCTCGTGGCCGGCTCCCGCAGCCGT
CGCGACCTGCGGGGGACTCTGCCGCACCCCTTGCAGCGCCTGAGGGTCCCGCCCCCGCCTCACGGGGCCCGTCGAGCCCGTAGCGTGGCC
TCCAGCTTGCGGGACAACAACCCCCAGGTGGACTGGAAGGACTGGAAGATCGGCTTCCAGCTGTGCAACCAGAACAAATCGGACTGCTTC
TACCAGACATACTCATCAGGGGTGGATGCGGTGAGGGAGTGGTACCGCTTCCACTACATCAACATCCTGTCGAGGCTGCCAGAGACTCTG
CCATCCCTGGAGGAGGACACGCTGGGCAACTTCATCTTCGCCTGCCGCTTCAACCAGGTCTCCTGCAACCAGGCGAATTACTCTCACTTC
CACCACCCGATGTATGGAAACTGCTATACTTTCAATGACAAGAACAACTCCAACCTCTGGATGTCTTCCATGCCTGGAATCAACAACGGT
CTGTCCCTGATGCTGCGCGCAGAGCAGAATGACTTCATTCCCCTGCTGTCCACAGTGACTGGGGCCCGGGTAATGGTGCACGGGCAGGAT
GAACCTGCCTTTATGGATGATGGTGGCTTTAACTTGCGGCCTGGCGTGGAGACCTCCATCAGCATGAGGAAGGAAACCCTGGACAGACTT
GGGGGCGATTATGGCGACTGCACCAAGAATGGCAGTGATGTTCCTGTTGAGAACCTTTACCCTTCAAAGTACACACAGCAGGTGTGTATT
CACTCCTGCTTCCAGGAGAGCATGATCAAGGAGTGTGGCTGTGCCTACATCTTCTATCCGCGGCCCCAGAACGTGGAGTACTGTGACTAC
AGAAAGCACAGTTCCTGGGGGTACTGCTACTATAAGCTCCAGGTTGACTTCTCCTCAGACCACCTGGGCTGTTTCACCAAGTGCCGGAAG
CCATGCAGCGTGACCAGCTACCAGCTCTCTGCTGGTTACTCACGATGGCCCTCGGTGACATCCCAGGAATGGGTCTTCCAGATGCTATCG
CGACAGAACAATTACACCGTCAACAACAAGAGAAATGGAGTGGCCAAAGTCAACATCTTCTTCAAGGAGCTGAACTACAAAACCAATTCT
GAGTCTCCCTCTGTCACGAATGATGACAACTTCTTAAATATAATCTATGAAGCCTATCTCTTCAGCATGACTCAAGCAGCCATGAAAAAG
ACTATGTGACAGCAAGGCCTTTTAAAACTGATTTTCAAGGTCCTTCTAGAACTCCGGCACAAGGTTCTTTCATGTTGAGTGTTGTTTCCT

>79707_79707_1_SCNN1A-DCP1B_SCNN1A_chr12_6457893_ENST00000228916_DCP1B_chr12_2055452_ENST00000280665_length(amino acids)=584AA_BP=552
MEEQDPRPLQPIPGLMEGNKLEEQDSSPPQSTPGLMKGNKREEQGLGPEPAAPQQPTAEEEALIEFHRSYRELFEFFCNNTTIHGAIRLV
CSQHNRMKTAFWAVLWLCTFGMMYWQFGLLFGEYFSYPVSLNINLNSDKLVFPAVTICTLNPYRYPEIKEELEELDRITEQTLFDLYKYS
SFTTLVAGSRSRRDLRGTLPHPLQRLRVPPPPHGARRARSVASSLRDNNPQVDWKDWKIGFQLCNQNKSDCFYQTYSSGVDAVREWYRFH
YINILSRLPETLPSLEEDTLGNFIFACRFNQVSCNQANYSHFHHPMYGNCYTFNDKNNSNLWMSSMPGINNGLSLMLRAEQNDFIPLLST
VTGARVMVHGQDEPAFMDDGGFNLRPGVETSISMRKETLDRLGGDYGDCTKNGSDVPVENLYPSKYTQQVCIHSCFQESMIKECGCAYIF
YPRPQNVEYCDYRKHSSWGYCYYKLQVDFSSDHLGCFTKCRKPCSVTSYQLSAGYSRWPSVTSQEWVFQMLSRQNNYTVNNKRNGVAKVN

--------------------------------------------------------------
>79707_79707_2_SCNN1A-DCP1B_SCNN1A_chr12_6457893_ENST00000540037_DCP1B_chr12_2055452_ENST00000397173_length(transcript)=1768nt_BP=1633nt
GCGGCACTCAAGCCGAAAGGCCACCGACACTCGCCTGCGGGGATCAGGGCGGGATGACCTGGGTACCGCGGTCACGCCAAGGCCGAGGCC
CTCACCCTTCCCCTCTTTGGGAAAGGGCAGACAAGTTCCGGGTTCCCTTCTAGGTCCGGGCGAGGGGGAGAGCGCCCCACAGACGACAGG
CGCCTCCTGCCTCTCTCCTTCAATAAACAGTCCACAGTGTCCCGGCTGGGCTCGCCGTGGCCTCCGCCTTCCCGGCGGACACACCTGTTT
ACCCTTCACCGCCGGACGGCCAGGAGGCGCCACGACGACCCCAGCCCCGCCCAGGCTTCTCCGGGATGGACCGGCCTCCCGGGGCACAGA
TGAGGACCCTGACCCCGGAGGGGCCAGACACTCGCTCCAGGGCCCCTGGCCTGACCCTCTTCCCCTCGCCCCTTCAGGTACCCGGAAATT
AAAGAGGAGCTGGAGGAGCTGGACCGCATCACAGAGCAGACGCTCTTTGACCTGTACAAATACAGCTCCTTCACCACTCTCGTGGCCGGC
TCCCGCAGCCGTCGCGACCTGCGGGGGACTCTGCCGCACCCCTTGCAGCGCCTGAGGGTCCCGCCCCCGCCTCACGGGGCCCGTCGAGCC
CGTAGCGTGGCCTCCAGCTTGCGGGACAACAACCCCCAGGTGGACTGGAAGGACTGGAAGATCGGCTTCCAGCTGTGCAACCAGAACAAA
TCGGACTGCTTCTACCAGACATACTCATCAGGGGTGGATGCGGTGAGGGAGTGGTACCGCTTCCACTACATCAACATCCTGTCGAGGCTG
CCAGAGACTCTGCCATCCCTGGAGGAGGACACGCTGGGCAACTTCATCTTCGCCTGCCGCTTCAACCAGGAATTACTCTCACTTCCACCA
CCCGATGTATGGAAACTGCTATACTTTCAATGACAAGAACAACTCCAACCTCTGGATGTCTTCCATGCCTGGAATCAACAACGGTCTGTC
CCTGATGCTGCGCGCAGAGCAGAATGACTTCATTCCCCTGCTGTCCACAGTGACTGGGGCCCGGGTAATGGTGCACGGGCAGGATGAACC
TGCCTTTATGGATGATGGTGGCTTTAACTTGCGGCCTGGCGTGGAGACCTCCATCAGCATGAGGAAGGAAACCCTGGACAGACTTGGGGG
CGATTATGGCGACTGCACCAAGAATGGCAGTGATGTTCCTGTTGAGAACCTTTACCCTTCAAAGTACACACAGCAGGTGTGTATTCACTC
CTGCTTCCAGGAGAGCATGATCAAGGAGTGTGGCTGTGCCTACATCTTCTATCCGCGGCCCCAGAACGTGGAGTACTGTGACTACAGAAA
GCACAGTTCCTGGGGGTACTGCTACTATAAGCTCCAGGTTGACTTCTCCTCAGACCACCTGGGCTGTTTCACCAAGTGCCGGAAGCCATG
CAGCGTGACCAGCTACCAGCTCTCTGCTGGTTACTCACGATGGCCCTCGGTGACATCCCAGGAATGGGTCTTCCAGATGCTATCGCGACA
GAACAATTACACCGTCAACAACAAGAGAAATGGAGTGGCCAAAGTCAACATCTTCTTCAAGGAGCTGAACTACAAAACCAATTCTGAGTC
TCCCTCTGTCACGAATGATGACAACTTCTTAAATATAATCTATGAAGCCTATCTCTTCAGCATGACTCAAGCAGCCATGAAAAAGACTAT

>79707_79707_2_SCNN1A-DCP1B_SCNN1A_chr12_6457893_ENST00000540037_DCP1B_chr12_2055452_ENST00000397173_length(amino acids)=269AA_BP=237
MYGNCYTFNDKNNSNLWMSSMPGINNGLSLMLRAEQNDFIPLLSTVTGARVMVHGQDEPAFMDDGGFNLRPGVETSISMRKETLDRLGGD
YGDCTKNGSDVPVENLYPSKYTQQVCIHSCFQESMIKECGCAYIFYPRPQNVEYCDYRKHSSWGYCYYKLQVDFSSDHLGCFTKCRKPCS

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Fusion Gene PPI Analysis for SCNN1A-DCP1B


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for SCNN1A-DCP1B


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for SCNN1A-DCP1B


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource