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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:SCP2-PJA2 (FusionGDB2 ID:79728)

Fusion Gene Summary for SCP2-PJA2

check button Fusion gene summary
Fusion gene informationFusion gene name: SCP2-PJA2
Fusion gene ID: 79728
HgeneTgene
Gene symbol

SCP2

PJA2

Gene ID

10388

9867

Gene namesynaptonemal complex protein 2praja ring finger ubiquitin ligase 2
SynonymsSCP-2|SCP2|SPGF1Neurodap1|RNF131
Cytomap

20q13.33

5q21.3

Type of geneprotein-codingprotein-coding
Descriptionsynaptonemal complex protein 2synaptonemal complex lateral element proteinE3 ubiquitin-protein ligase Praja-2RING-type E3 ubiquitin transferase Praja-2praja 2, RING-H2 motif containingpraja ring finger 2, E3 ubiquitin protein ligasepraja2ring finger protein 131
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000371514, ENST00000408941, 
ENST00000488965, ENST00000407246, 
ENST00000371509, ENST00000371513, 
ENST00000430330, ENST00000435345, 
ENST00000473584, ENST00000528311, 
ENST00000361189, ENST00000361557, 
ENST00000511624, 
Fusion gene scores* DoF score9 X 8 X 4=2886 X 6 X 3=108
# samples 96
** MAII scorelog2(9/288*10)=-1.67807190511264
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(6/108*10)=-0.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SCP2 [Title/Abstract] AND PJA2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointSCP2(53516929)-PJA2(108714077), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgenePJA2

GO:0016567

protein ubiquitination

21423175


check buttonFusion gene breakpoints across SCP2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across PJA2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/AAI082430SCP2chr1

53516929

-PJA2chr5

108714077

+


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Fusion Gene ORF analysis for SCP2-PJA2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000371514ENST00000361189SCP2chr1

53516929

-PJA2chr5

108714077

+
3UTR-3CDSENST00000371514ENST00000361557SCP2chr1

53516929

-PJA2chr5

108714077

+
3UTR-3CDSENST00000408941ENST00000361189SCP2chr1

53516929

-PJA2chr5

108714077

+
3UTR-3CDSENST00000408941ENST00000361557SCP2chr1

53516929

-PJA2chr5

108714077

+
3UTR-3CDSENST00000488965ENST00000361189SCP2chr1

53516929

-PJA2chr5

108714077

+
3UTR-3CDSENST00000488965ENST00000361557SCP2chr1

53516929

-PJA2chr5

108714077

+
3UTR-intronENST00000371514ENST00000511624SCP2chr1

53516929

-PJA2chr5

108714077

+
3UTR-intronENST00000408941ENST00000511624SCP2chr1

53516929

-PJA2chr5

108714077

+
3UTR-intronENST00000488965ENST00000511624SCP2chr1

53516929

-PJA2chr5

108714077

+
5CDS-intronENST00000407246ENST00000511624SCP2chr1

53516929

-PJA2chr5

108714077

+
In-frameENST00000407246ENST00000361189SCP2chr1

53516929

-PJA2chr5

108714077

+
In-frameENST00000407246ENST00000361557SCP2chr1

53516929

-PJA2chr5

108714077

+
intron-3CDSENST00000371509ENST00000361189SCP2chr1

53516929

-PJA2chr5

108714077

+
intron-3CDSENST00000371509ENST00000361557SCP2chr1

53516929

-PJA2chr5

108714077

+
intron-3CDSENST00000371513ENST00000361189SCP2chr1

53516929

-PJA2chr5

108714077

+
intron-3CDSENST00000371513ENST00000361557SCP2chr1

53516929

-PJA2chr5

108714077

+
intron-3CDSENST00000430330ENST00000361189SCP2chr1

53516929

-PJA2chr5

108714077

+
intron-3CDSENST00000430330ENST00000361557SCP2chr1

53516929

-PJA2chr5

108714077

+
intron-3CDSENST00000435345ENST00000361189SCP2chr1

53516929

-PJA2chr5

108714077

+
intron-3CDSENST00000435345ENST00000361557SCP2chr1

53516929

-PJA2chr5

108714077

+
intron-3CDSENST00000473584ENST00000361189SCP2chr1

53516929

-PJA2chr5

108714077

+
intron-3CDSENST00000473584ENST00000361557SCP2chr1

53516929

-PJA2chr5

108714077

+
intron-3CDSENST00000528311ENST00000361189SCP2chr1

53516929

-PJA2chr5

108714077

+
intron-3CDSENST00000528311ENST00000361557SCP2chr1

53516929

-PJA2chr5

108714077

+
intron-intronENST00000371509ENST00000511624SCP2chr1

53516929

-PJA2chr5

108714077

+
intron-intronENST00000371513ENST00000511624SCP2chr1

53516929

-PJA2chr5

108714077

+
intron-intronENST00000430330ENST00000511624SCP2chr1

53516929

-PJA2chr5

108714077

+
intron-intronENST00000435345ENST00000511624SCP2chr1

53516929

-PJA2chr5

108714077

+
intron-intronENST00000473584ENST00000511624SCP2chr1

53516929

-PJA2chr5

108714077

+
intron-intronENST00000528311ENST00000511624SCP2chr1

53516929

-PJA2chr5

108714077

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000407246SCP2chr153516929-ENST00000361189PJA2chr5108714077+57782239391682547
ENST00000407246SCP2chr153516929-ENST00000361557PJA2chr5108714077+57742239391682547

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000407246ENST00000361189SCP2chr153516929-PJA2chr5108714077+0.0001376090.9998623
ENST00000407246ENST00000361557SCP2chr153516929-PJA2chr5108714077+0.000137840.9998622

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Fusion Genomic Features for SCP2-PJA2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for SCP2-PJA2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:53516929/chr5:108714077)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSCP2chr1:53516929chr5:108714077ENST00000407246-1515433_543709524.0DomainNote=SCP2
HgeneSCP2chr1:53516929chr5:108714077ENST00000407246-1515545_547709524.0MotifMicrobody targeting signal
TgenePJA2chr1:53516929chr5:108714077ENST00000361189010634_6750709.0Zinc fingerRING-type%3B atypical
TgenePJA2chr1:53516929chr5:108714077ENST0000036155709634_6750709.0Zinc fingerRING-type%3B atypical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSCP2chr1:53516929chr5:108714077ENST00000371509-115433_5430504.0DomainNote=SCP2
HgeneSCP2chr1:53516929chr5:108714077ENST00000371513-111433_5430323.0DomainNote=SCP2
HgeneSCP2chr1:53516929chr5:108714077ENST00000371514-116433_5430548.0DomainNote=SCP2
HgeneSCP2chr1:53516929chr5:108714077ENST00000408941-14433_5430361.0DomainNote=SCP2
HgeneSCP2chr1:53516929chr5:108714077ENST00000430330-15433_5430141.0DomainNote=SCP2
HgeneSCP2chr1:53516929chr5:108714077ENST00000435345-15433_5430144.0DomainNote=SCP2
HgeneSCP2chr1:53516929chr5:108714077ENST00000488965-13433_543060.0DomainNote=SCP2
HgeneSCP2chr1:53516929chr5:108714077ENST00000528311-115433_5430467.0DomainNote=SCP2
HgeneSCP2chr1:53516929chr5:108714077ENST00000371509-115545_5470504.0MotifMicrobody targeting signal
HgeneSCP2chr1:53516929chr5:108714077ENST00000371513-111545_5470323.0MotifMicrobody targeting signal
HgeneSCP2chr1:53516929chr5:108714077ENST00000371514-116545_5470548.0MotifMicrobody targeting signal
HgeneSCP2chr1:53516929chr5:108714077ENST00000408941-14545_5470361.0MotifMicrobody targeting signal
HgeneSCP2chr1:53516929chr5:108714077ENST00000430330-15545_5470141.0MotifMicrobody targeting signal
HgeneSCP2chr1:53516929chr5:108714077ENST00000435345-15545_5470144.0MotifMicrobody targeting signal
HgeneSCP2chr1:53516929chr5:108714077ENST00000488965-13545_547060.0MotifMicrobody targeting signal
HgeneSCP2chr1:53516929chr5:108714077ENST00000528311-115545_5470467.0MotifMicrobody targeting signal


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Fusion Gene Sequence for SCP2-PJA2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>79728_79728_1_SCP2-PJA2_SCP2_chr1_53516929_ENST00000407246_PJA2_chr5_108714077_ENST00000361189_length(transcript)=5778nt_BP=2239nt
GTTGCCGCCCGCGGCCCTGGCTTCGGGCTTCAGGGAGCTCTGGTGCAGTCTCCGCCTGTCAGTGCCGGCAGTCGTCCGCGGCGCCCGCCC
CGGTCCCGCACTGGTGCAGCCATGTCCTCTTCCCCGTGGGAGCCTGCGACCCTGCGCCGGGTGTTCGTGGTGGGGGTTGGCATGACCAAG
TTTGTGAAGCCTGGAGCTGAGAATTCAAGAGACTACCCTGACTTGGCAGAAGAAGCAGGTGACTCTACCTGTGGGCAGAGGGCTATCTAT
CACAGTTTGGGAATGACTGGAATTCCTATAATCAATGTCAACAATAACTGTGCTACTGGTTCTACTGCTTTGTTTATGGCCCGCCAGCTG
ATTCAGGGTGGTGTGGCAGAATGTGTCTTGGCTCTTGGGTTTGAGAAGATGAGTAAGGGAAGCCTTGGAATAAAATTTTCAGATAGAACC
ATTCCCACTGATAAGCATGTTGACCTCCTGATCAATAAGTATGGATTGTCTGCTCACCCAGTTGCTCCTCAGATGTTTGGGTATGCTGGA
AAAGAACATATGGAAAAATATGGAACAAAAATTGAACACTTTGCAAAAATTGGATGGAAAAATCATAAACATTCAGTTAATAACCCGTAT
TCCCAGTTCCAAGATGAATACAGTTTAGATGAAGTGATGGCATCTAAAGAAGTTTTTGATTTTTTGACTATCTTACAATGTTGTCCCACT
TCAGATGGTGCTGCAGCAGCAATTTTGGCCAGTGAAGCATTTGTACAGAAGTATGGCCTGCAATCCAAAGCTGTGGAAATTTTGGCACAA
GAAATGATGACTGATTTGCCAAGCTCGTTTGAAGAAAAAAGCATTATTAAAATGGTTGGCTTTGATATGAGTAAAGAAGCTGCAAGAAAA
TGCTATGAGAAATCTGGCCTGACACCAAATGATATTGACGTAATAGAACTTCACGATTGCTTTTCTACCAACGAACTCCTTACTTATGAA
GCACTGGGACTCTGTCCAGAAGGACAAGGTGCAACGCTGGTTGATAGAGGAGATAATACATATGGAGGAAAGTGGGTCATAAATCCTAGT
GGTGGACTGATTTCAAAGGGACACCCACTAGGCGCTACAGGTCTTGCTCAGTGTGCAGAACTCTGCTGGCAGCTGAGAGGGGAAGCCGGA
AAGAGGCAAGTTCCTGGTGCAAAGGTGGCTCTGCAGCATAATTTAGGCATTGGAGGAGCTGTGGTTGTAACACTCTACAAGATGGGTTTT
CCGGAAGCCGCCAGTTCTTTTAGAACTCATCAAATTGAAGCTGTTCCAACCAGCTCTGCAAGTGATGGATTTAAGGCAAATCTTGTTTTT
AAGGAGATTGAGAAGAAACTTGAAGAGGAAGGGGAACAGTTTGTGAAGAAAATCGGTGGTATTTTTGCCTTCAAGGTGAAAGATGGCCCT
GGGGGTAAAGAGGCCACCTGGGTGGTGGATGTGAAGAATGGCAAAGGATCAGTGCTTCCTAACTCAGATAAGAAGGCTGACTGCACAATC
ACAATGGCTGACTCAGACTTCCTGGCTTTAATGACTGGTAAAATGAATCCTCAGTCGGCCTTCTTTCAAGGCAAATTGAAAATCACTGGC
AACATGGGTCTCGCTATGAAGTTACAAAATCTTCAGCTTCAGCCAGGCAACGCTAAGCTCTGAAGAACTCCCTTTGGCTACTTTTGAAAA
TCAAGATGAGATATATAGATATATATCCATACATTTTATTGTCAGAATTTAGACTGAAACTACACATTGGCAAATAGCGTGGGATAGATT
TGTTTCTTAATGGGTGTGACCAATCCTGTTTTTCCTATGCTCTGGGTGAATAGAGCCTGATGGTATACTACTGCTTTGCGGAATTGCATA
CAACTGTGCATTACAAAGTTAATATGGTAATTATGGTCTGGGGTAAAATTGAGTTTCAGAATAAAATTAGGAACAGTAAAATCCAAAGAA
CTATGTAAACAAAAAAGCTTTTGTTTTGCTTACAAAGTATATTTAAGGATTATTCTGCTGAAGATTCAGTTTAAGAGTTTTCCTTGGGAG
AACTAAGTAAGAAACACAATGCCAACAGCTGGCCAGTAATTAGTGTTGTGCACTTCATGTCATTAATCAATTTCTCAATAGTTCTTAAAA
TTAGTGAGATTAAAAATCTAAAAATTTTGCATTTCATGCTATCAGAAACAGTATTTTCTTCCCAAATCAAAATAAAAGATCGGGAACATG
CCCTGTGTGCCGCCGTCATTTCCCACCTGCGGTTATTGAAGCATCTGCAGCTCCTTCCTCTGAGCCTGATCCTGATGCCCCACCTTCAAA
TGACAGTATTGCAGAAGCACCCTAAACCTTGACAGTTGAAATGAGATCAGTGTATCAAAGTAAATCTGCAAATTCCTTCTAAATTTCATG
TGCAAATAATTATATATAAATATATTTAAAAATGCTATATATAGTATATGCCATAGTTTAGAAAGAATATTAACCTTTCTAAACTAAATT
TAGGTTTGCAGAAAGTATTAAACATTTTTAAGCTGAATGTTGAGACAGTGCATCCATTTTCTTTAGTTGAATATGTTTGTATTAATTGTA
AAGCCAAGCTTATCAGTTGACTCTCTCCAGAATAAATAATCATCTGTGTGGCATACGTTATTGGCTTTGTCTGTAATACTGCCACTAAGT
GATTATAATTAAGCTGTCCTGTTTGCATCAAATGTAAAGACTGTGTTCACAACCGTAGTAAAATTTGGTTTCATTGGAAATGAAACAAAT
TCTAAAGTATGCTTTTTCACTAGTCCCTTTGATTTTGCTATATCATAACCTCTTGGTTCATATGCTGAGAAATTTTTCAGAAAGTCCATT
TTTGTTTAAAATTAGAACTTTTCAGAATGCCAAATGAAGGCTAAAATTTTGGCCAGAACATTACAAAAGTTTTAAATCGTAGACGTAACT
CCCCCTGAAATAAAGTTAGGTAGTAAAATCCTTAATGAAACCAGTGGATGTGCTTAACGTAAGGTTAGTAAAGCATACAAAGAATCTAGT
GTGCTCAGGGCTTGGTACAATGAGCTGAATTAGATGGCCTTATGAAACTCTTTCTAACCTCTTACCCAACCTGTTTCTCCTTGGTTAAAA
TTATACTTGAAGGCCCAGAACACTCATGGCACATTTGTTTAATATTGCTTATAGTTAGTTTAAGGTAATTTTGCTTCTACAGTATTTTGG
AAGGTCTGAAAACTTGCACAGGGTCATCTTTGTAATTATATAACCCCAAACTAAGATGCACAATGTCTCCTTCAGGTGATCACACACAGT
GGACGAGTATGTGCAAACATGGACATAATAGTTCACTTACAAATGTGATTTGATGTTAACACTAGAGAATGATGACTGTAGAACATTTGA
GCAAGTAAAATAGTAAAGCACATAGTGAGTGTATGTCCGTCTAACTGGTACATTGATAATTTAGTTTGGGCACATAAAAGGAATATTTAT
ATGGCTTCCCAAATGCAGAGTTACATCTTATTCGTGTATTTCTCTGAGTATTTATATCCCGTCTCCTTTTTTCATTCTTAAAAATAAATG
AATTTTCACTGTTGGCACATATGAGGCTTAAATATAAGGAACATAACACTTGCATTCTAATTTTTGCATATATTGTAAATGTGTCTGGTA
TTTACAGCAAAATACTGTGTATCCTTTTATGGGTAAAACAAAAGTGAACATTGCATGCATGTAATGTGATGAATTTGTAATTTAGGAGTT
CTTTGGGGCTTCTGTGACTTGGGAAATGCTTACATTCAGGCCTTAATGTTGCATTAGCTAGCATGTTTTCCCTCTGATGTATATAGTCAC
TGTTGTATAAACTAATCTTTGCTTGTTTTCTACTCTGTGATCTTTCCATATCATATTTCATTAATGATCAGTTAGTGTCAAGGAGTCAAA
ACAGATTAAAATTAATTTCATGTGTATATGGTGGAAATTTGTGGCTAGTGTGATTTTTGTTTGTTTCCTTTTAAGTACTGTTGATCAGTT
GTGACACTTACTGGTTAAACTTACGTTGCTAAAGATTTCTCTATAATAAGCCACACATTATATTTAGACTATATTAAGGGACCTTGGTTT
TCTTCTAGATAGCAGCTGTCCCAAAGAAAATATTTCTTCTTTGTCTGTTAAGATTTAGCTATTATCTGCCAGTTGTTAAGAGGTTTTGGT
TCCAAACTCAACCAGCAATGTTGAGAGCTGAACTTAAGATAGCTGTTGTACTTTTTGCTTTCCATCTGTTACTGTCCTTCATTCTTGGCT
CCCTACTATCTATAAACAGCTGCTGTGAAGAAGAAAAGTTGAATAAGAGTTGGCTTAAATTTTAAAAAAGAAAAAGAAAATTGAGGTTTT
AGGATTTTCATGGTAACAAGCTCTGGTATAAGCTAAGGCTGGCAAGTTCAGATACTAAAATATTATTTGATCATATCTTGGATCCTTTTG
AAAAAGTTAAGACTATATGAAGGTAAATTAGAAATAAGTATGAATATTAATAAAATAGCATTTATCTTATTTCTCTATTTTATGTTGTGA
CTTAACCTAATTTTATTTTTTTAACATTTTCTTATTTCTTATAATATGAATGCTGATATTTAAAGGTAGATCTATGTGGTATTCTTTGTG
TTTCTTAATTGTTTAACTCTTAAGATTATTTGTGATCTGGATTTATGTATTTGTTAGATACATACGAATTGTTAAAATGGAATGCAAGTT
TTTCAAAAGCCCAGGTCTAAATGTAATGGTTGGTTTATTGTTCTATAACCCCAGCCCATCATTTTCTGTGTAAATCATAAACAATAAACA
GAATATACTCGGTGGTCATTTCTAATACTATTGGTCAGGAACAATGCTGTCCAATCTGTTGCAGTGAGTATATTAAGGATGATATAGCAA
CAGAGTTGCCCTGTCACCATTTCTTTCACAAACCTTGTGTCTCAATTTGGCTACAAAAGACTGCTCTGGCCCATTTAGAGTCTCTTGCAG
TGGATGTTGAGGTGGCCAATCCACCAGCTAGTAAGGAAAGCATTGATGGTCTTCCAGAGACCCTTGTTCTTGAAGATCACACTGCCTATT
TGATGGCTTTGCAGATGGACTAGGAGTTGCTGAAGCTATTTCATATGTGGATCCTCAGTTCCTTACCTACATGGCACTAGAAGAACGCTT
AGCCCAGGCTATGGAGGGAACAGACATCCTTGGAAGAGGGAGAAATTCCTTGGTTACAGTACAATGAAGTCAATGAAAGCAGCAGTGATG
AGGGAAATGAACCTGCCAATGAATTTGCACAGCCAGCTTTCATGTTGGATGGTAACAATAACCTGGAGGATGACTCCAGTGTGAGTGAAG
ACTTAGATGTGGATTGGAGTTCTGAATGCAGTGATGGGGAATGGTCTGCTTCTTTGCCTCATCGATTTTCTGGTACAGAAAAAGATCAAT
CCTCAAGTGATGAAAGCTGGGAGACTCTGCCAGGAAAAGATGAGAATGAACCTGAGCTACAAAGTGATAGCAGTGGCCCTGAAGAAGAAA
ACCAAGAATTATCTCTTCAGGAAGGCATGACTGTATGTTCTTGGATCCACCATACTCAAGAGTTATTACACAAAGGGAAACAGAAAATAA
CCAAATGACATCAGAAAGTGGAGCCACAGCAGGAAGGCAAGAGGTGGATAACACCTTTTGGAATGGCTGTGGAGATTATTACCAACTCTA

>79728_79728_1_SCP2-PJA2_SCP2_chr1_53516929_ENST00000407246_PJA2_chr5_108714077_ENST00000361189_length(amino acids)=547AA_BP=
MVQSPPVSAGSRPRRPPRSRTGAAMSSSPWEPATLRRVFVVGVGMTKFVKPGAENSRDYPDLAEEAGDSTCGQRAIYHSLGMTGIPIINV
NNNCATGSTALFMARQLIQGGVAECVLALGFEKMSKGSLGIKFSDRTIPTDKHVDLLINKYGLSAHPVAPQMFGYAGKEHMEKYGTKIEH
FAKIGWKNHKHSVNNPYSQFQDEYSLDEVMASKEVFDFLTILQCCPTSDGAAAAILASEAFVQKYGLQSKAVEILAQEMMTDLPSSFEEK
SIIKMVGFDMSKEAARKCYEKSGLTPNDIDVIELHDCFSTNELLTYEALGLCPEGQGATLVDRGDNTYGGKWVINPSGGLISKGHPLGAT
GLAQCAELCWQLRGEAGKRQVPGAKVALQHNLGIGGAVVVTLYKMGFPEAASSFRTHQIEAVPTSSASDGFKANLVFKEIEKKLEEEGEQ
FVKKIGGIFAFKVKDGPGGKEATWVVDVKNGKGSVLPNSDKKADCTITMADSDFLALMTGKMNPQSAFFQGKLKITGNMGLAMKLQNLQL

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>79728_79728_2_SCP2-PJA2_SCP2_chr1_53516929_ENST00000407246_PJA2_chr5_108714077_ENST00000361557_length(transcript)=5774nt_BP=2239nt
GTTGCCGCCCGCGGCCCTGGCTTCGGGCTTCAGGGAGCTCTGGTGCAGTCTCCGCCTGTCAGTGCCGGCAGTCGTCCGCGGCGCCCGCCC
CGGTCCCGCACTGGTGCAGCCATGTCCTCTTCCCCGTGGGAGCCTGCGACCCTGCGCCGGGTGTTCGTGGTGGGGGTTGGCATGACCAAG
TTTGTGAAGCCTGGAGCTGAGAATTCAAGAGACTACCCTGACTTGGCAGAAGAAGCAGGTGACTCTACCTGTGGGCAGAGGGCTATCTAT
CACAGTTTGGGAATGACTGGAATTCCTATAATCAATGTCAACAATAACTGTGCTACTGGTTCTACTGCTTTGTTTATGGCCCGCCAGCTG
ATTCAGGGTGGTGTGGCAGAATGTGTCTTGGCTCTTGGGTTTGAGAAGATGAGTAAGGGAAGCCTTGGAATAAAATTTTCAGATAGAACC
ATTCCCACTGATAAGCATGTTGACCTCCTGATCAATAAGTATGGATTGTCTGCTCACCCAGTTGCTCCTCAGATGTTTGGGTATGCTGGA
AAAGAACATATGGAAAAATATGGAACAAAAATTGAACACTTTGCAAAAATTGGATGGAAAAATCATAAACATTCAGTTAATAACCCGTAT
TCCCAGTTCCAAGATGAATACAGTTTAGATGAAGTGATGGCATCTAAAGAAGTTTTTGATTTTTTGACTATCTTACAATGTTGTCCCACT
TCAGATGGTGCTGCAGCAGCAATTTTGGCCAGTGAAGCATTTGTACAGAAGTATGGCCTGCAATCCAAAGCTGTGGAAATTTTGGCACAA
GAAATGATGACTGATTTGCCAAGCTCGTTTGAAGAAAAAAGCATTATTAAAATGGTTGGCTTTGATATGAGTAAAGAAGCTGCAAGAAAA
TGCTATGAGAAATCTGGCCTGACACCAAATGATATTGACGTAATAGAACTTCACGATTGCTTTTCTACCAACGAACTCCTTACTTATGAA
GCACTGGGACTCTGTCCAGAAGGACAAGGTGCAACGCTGGTTGATAGAGGAGATAATACATATGGAGGAAAGTGGGTCATAAATCCTAGT
GGTGGACTGATTTCAAAGGGACACCCACTAGGCGCTACAGGTCTTGCTCAGTGTGCAGAACTCTGCTGGCAGCTGAGAGGGGAAGCCGGA
AAGAGGCAAGTTCCTGGTGCAAAGGTGGCTCTGCAGCATAATTTAGGCATTGGAGGAGCTGTGGTTGTAACACTCTACAAGATGGGTTTT
CCGGAAGCCGCCAGTTCTTTTAGAACTCATCAAATTGAAGCTGTTCCAACCAGCTCTGCAAGTGATGGATTTAAGGCAAATCTTGTTTTT
AAGGAGATTGAGAAGAAACTTGAAGAGGAAGGGGAACAGTTTGTGAAGAAAATCGGTGGTATTTTTGCCTTCAAGGTGAAAGATGGCCCT
GGGGGTAAAGAGGCCACCTGGGTGGTGGATGTGAAGAATGGCAAAGGATCAGTGCTTCCTAACTCAGATAAGAAGGCTGACTGCACAATC
ACAATGGCTGACTCAGACTTCCTGGCTTTAATGACTGGTAAAATGAATCCTCAGTCGGCCTTCTTTCAAGGCAAATTGAAAATCACTGGC
AACATGGGTCTCGCTATGAAGTTACAAAATCTTCAGCTTCAGCCAGGCAACGCTAAGCTCTGAAGAACTCCCTTTGGCTACTTTTGAAAA
TCAAGATGAGATATATAGATATATATCCATACATTTTATTGTCAGAATTTAGACTGAAACTACACATTGGCAAATAGCGTGGGATAGATT
TGTTTCTTAATGGGTGTGACCAATCCTGTTTTTCCTATGCTCTGGGTGAATAGAGCCTGATGGTATACTACTGCTTTGCGGAATTGCATA
CAACTGTGCATTACAAAGTTAATATGGTAATTATGGTCTGGGGTAAAATTGAGTTTCAGAATAAAATTAGGAACAGTAAAATCCAAAGAA
CTATGTAAACAAAAAAGCTTTTGTTTTGCTTACAAAGTATATTTAAGGATTATTCTGCTGAAGATTCAGTTTAAGAGTTTTCCTTGGGAG
AACTAAGTAAGAAACACAATGCCAACAGCTGGCCAGTAATTAGTGTTGTGCACTTCATGTCATTAATCAATTTCTCAATAGTTCTTAAAA
TTAGTGAGATTAAAAATCTAAAAATTTTGCATTTCATGCTATCAGAAACAGTATTTTCTTCCCAAATCAAAATAAAAGATCGGGAACATG
CCCTGTGTGCCGCCGTCATTTCCCACCTGCGGTTATTGAAGCATCTGCAGCTCCTTCCTCTGAGCCTGATCCTGATGCCCCACCTTCAAA
TGACAGTATTGCAGAAGCACCCTAAACCTTGACAGTTGAAATGAGATCAGTGTATCAAAGTAAATCTGCAAATTCCTTCTAAATTTCATG
TGCAAATAATTATATATAAATATATTTAAAAATGCTATATATAGTATATGCCATAGTTTAGAAAGAATATTAACCTTTCTAAACTAAATT
TAGGTTTGCAGAAAGTATTAAACATTTTTAAGCTGAATGTTGAGACAGTGCATCCATTTTCTTTAGTTGAATATGTTTGTATTAATTGTA
AAGCCAAGCTTATCAGTTGACTCTCTCCAGAATAAATAATCATCTGTGTGGCATACGTTATTGGCTTTGTCTGTAATACTGCCACTAAGT
GATTATAATTAAGCTGTCCTGTTTGCATCAAATGTAAAGACTGTGTTCACAACCGTAGTAAAATTTGGTTTCATTGGAAATGAAACAAAT
TCTAAAGTATGCTTTTTCACTAGTCCCTTTGATTTTGCTATATCATAACCTCTTGGTTCATATGCTGAGAAATTTTTCAGAAAGTCCATT
TTTGTTTAAAATTAGAACTTTTCAGAATGCCAAATGAAGGCTAAAATTTTGGCCAGAACATTACAAAAGTTTTAAATCGTAGACGTAACT
CCCCCTGAAATAAAGTTAGGTAGTAAAATCCTTAATGAAACCAGTGGATGTGCTTAACGTAAGGTTAGTAAAGCATACAAAGAATCTAGT
GTGCTCAGGGCTTGGTACAATGAGCTGAATTAGATGGCCTTATGAAACTCTTTCTAACCTCTTACCCAACCTGTTTCTCCTTGGTTAAAA
TTATACTTGAAGGCCCAGAACACTCATGGCACATTTGTTTAATATTGCTTATAGTTAGTTTAAGGTAATTTTGCTTCTACAGTATTTTGG
AAGGTCTGAAAACTTGCACAGGGTCATCTTTGTAATTATATAACCCCAAACTAAGATGCACAATGTCTCCTTCAGGTGATCACACACAGT
GGACGAGTATGTGCAAACATGGACATAATAGTTCACTTACAAATGTGATTTGATGTTAACACTAGAGAATGATGACTGTAGAACATTTGA
GCAAGTAAAATAGTAAAGCACATAGTGAGTGTATGTCCGTCTAACTGGTACATTGATAATTTAGTTTGGGCACATAAAAGGAATATTTAT
ATGGCTTCCCAAATGCAGAGTTACATCTTATTCGTGTATTTCTCTGAGTATTTATATCCCGTCTCCTTTTTTCATTCTTAAAAATAAATG
AATTTTCACTGTTGGCACATATGAGGCTTAAATATAAGGAACATAACACTTGCATTCTAATTTTTGCATATATTGTAAATGTGTCTGGTA
TTTACAGCAAAATACTGTGTATCCTTTTATGGGTAAAACAAAAGTGAACATTGCATGCATGTAATGTGATGAATTTGTAATTTAGGAGTT
CTTTGGGGCTTCTGTGACTTGGGAAATGCTTACATTCAGGCCTTAATGTTGCATTAGCTAGCATGTTTTCCCTCTGATGTATATAGTCAC
TGTTGTATAAACTAATCTTTGCTTGTTTTCTACTCTGTGATCTTTCCATATCATATTTCATTAATGATCAGTTAGTGTCAAGGAGTCAAA
ACAGATTAAAATTAATTTCATGTGTATATGGTGGAAATTTGTGGCTAGTGTGATTTTTGTTTGTTTCCTTTTAAGTACTGTTGATCAGTT
GTGACACTTACTGGTTAAACTTACGTTGCTAAAGATTTCTCTATAATAAGCCACACATTATATTTAGACTATATTAAGGGACCTTGGTTT
TCTTCTAGATAGCAGCTGTCCCAAAGAAAATATTTCTTCTTTGTCTGTTAAGATTTAGCTATTATCTGCCAGTTGTTAAGAGGTTTTGGT
TCCAAACTCAACCAGCAATGTTGAGAGCTGAACTTAAGATAGCTGTTGTACTTTTTGCTTTCCATCTGTTACTGTCCTTCATTCTTGGCT
CCCTACTATCTATAAACAGCTGCTGTGAAGAAGAAAAGTTGAATAAGAGTTGGCTTAAATTTTAAAAAAGAAAAAGAAAATTGAGGTTTT
AGGATTTTCATGGTAACAAGCTCTGGTATAAGCTAAGGCTGGCAAGTTCAGATACTAAAATATTATTTGATCATATCTTGGATCCTTTTG
AAAAAGTTAAGACTATATGAAGGTAAATTAGAAATAAGTATGAATATTAATAAAATAGCATTTATCTTATTTCTCTATTTTATGTTGTGA
CTTAACCTAATTTTATTTTTTTAACATTTTCTTATTTCTTATAATATGAATGCTGATATTTAAAGGTAGATCTATGTGGTATTCTTTGTG
TTTCTTAATTGTTTAACTCTTAAGATTATTTGTGATCTGGATTTATGTATTTGTTAGATACATACGAATTGTTAAAATGGAATGCAAGTT
TTTCAAAAGCCCAGGTCTAAATGTAATGGTTGGTTTATTGTTCTATAACCCCAGCCCATCATTTTCTGTGTAAATCATAAACAATAAACA
GAATATACTCGGTGGTCATTTCTCTATTGGTCAGGAACAATGCTGTCCAATCTGTTGCAGTGAGTATATTAAGGATGATATAGCAACAGA
GTTGCCCTGTCACCATTTCTTTCACAAACCTTGTGTCTCAATTTGGCTACAAAAGACTGCTCTGGCCCATTTAGAGTCTCTTGCAGTGGA
TGTTGAGGTGGCCAATCCACCAGCTAGTAAGGAAAGCATTGATGGTCTTCCAGAGACCCTTGTTCTTGAAGATCACACTGCCTATTTGAT
GGCTTTGCAGATGGACTAGGAGTTGCTGAAGCTATTTCATATGTGGATCCTCAGTTCCTTACCTACATGGCACTAGAAGAACGCTTAGCC
CAGGCTATGGAGGGAACAGACATCCTTGGAAGAGGGAGAAATTCCTTGGTTACAGTACAATGAAGTCAATGAAAGCAGCAGTGATGAGGG
AAATGAACCTGCCAATGAATTTGCACAGCCAGCTTTCATGTTGGATGGTAACAATAACCTGGAGGATGACTCCAGTGTGAGTGAAGACTT
AGATGTGGATTGGAGTTCTGAATGCAGTGATGGGGAATGGTCTGCTTCTTTGCCTCATCGATTTTCTGGTACAGAAAAAGATCAATCCTC
AAGTGATGAAAGCTGGGAGACTCTGCCAGGAAAAGATGAGAATGAACCTGAGCTACAAAGTGATAGCAGTGGCCCTGAAGAAGAAAACCA
AGAATTATCTCTTCAGGAAGGCATGACTGTATGTTCTTGGATCCACCATACTCAAGAGTTATTACACAAAGGGAAACAGAAAATAACCAA
ATGACATCAGAAAGTGGAGCCACAGCAGGAAGGCAAGAGGTGGATAACACCTTTTGGAATGGCTGTGGAGATTATTACCAACTCTATGAC

>79728_79728_2_SCP2-PJA2_SCP2_chr1_53516929_ENST00000407246_PJA2_chr5_108714077_ENST00000361557_length(amino acids)=547AA_BP=
MVQSPPVSAGSRPRRPPRSRTGAAMSSSPWEPATLRRVFVVGVGMTKFVKPGAENSRDYPDLAEEAGDSTCGQRAIYHSLGMTGIPIINV
NNNCATGSTALFMARQLIQGGVAECVLALGFEKMSKGSLGIKFSDRTIPTDKHVDLLINKYGLSAHPVAPQMFGYAGKEHMEKYGTKIEH
FAKIGWKNHKHSVNNPYSQFQDEYSLDEVMASKEVFDFLTILQCCPTSDGAAAAILASEAFVQKYGLQSKAVEILAQEMMTDLPSSFEEK
SIIKMVGFDMSKEAARKCYEKSGLTPNDIDVIELHDCFSTNELLTYEALGLCPEGQGATLVDRGDNTYGGKWVINPSGGLISKGHPLGAT
GLAQCAELCWQLRGEAGKRQVPGAKVALQHNLGIGGAVVVTLYKMGFPEAASSFRTHQIEAVPTSSASDGFKANLVFKEIEKKLEEEGEQ
FVKKIGGIFAFKVKDGPGGKEATWVVDVKNGKGSVLPNSDKKADCTITMADSDFLALMTGKMNPQSAFFQGKLKITGNMGLAMKLQNLQL

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Fusion Gene PPI Analysis for SCP2-PJA2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
TgenePJA2chr1:53516929chr5:108714077ENST00000361189010531_7080709.0PRKAR1A%2C PRKAR2A and PRKAR2B
TgenePJA2chr1:53516929chr5:108714077ENST0000036155709531_7080709.0PRKAR1A%2C PRKAR2A and PRKAR2B


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for SCP2-PJA2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for SCP2-PJA2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource