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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:SCRIB-NRBP2 (FusionGDB2 ID:79740)

Fusion Gene Summary for SCRIB-NRBP2

check button Fusion gene summary
Fusion gene informationFusion gene name: SCRIB-NRBP2
Fusion gene ID: 79740
HgeneTgene
Gene symbol

SCRIB

NRBP2

Gene ID

23513

340371

Gene namescribble planar cell polarity proteinnuclear receptor binding protein 2
SynonymsCRIB1|SCRB1|SCRIB1|VartulTRG16|pp9320
Cytomap

8q24.3

8q24.3

Type of geneprotein-codingprotein-coding
Descriptionprotein scribble homologscribbled homologscribbled planar cell polarity proteinnuclear receptor-binding protein 2transformation-related protein 16
Modification date2020031320200320
UniProtAcc.

Q9NSY0

Ensembl transtripts involved in fusion geneENST00000320476, ENST00000356994, 
ENST00000377533, ENST00000546337, 
ENST00000327830, ENST00000442628, 
Fusion gene scores* DoF score5 X 9 X 4=1803 X 3 X 3=27
# samples 63
** MAII scorelog2(6/180*10)=-1.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: SCRIB [Title/Abstract] AND NRBP2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointSCRIB(144897384)-NRBP2(144922401), # samples:3
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneSCRIB

GO:0008283

cell proliferation

16965391

HgeneSCRIB

GO:0045930

negative regulation of mitotic cell cycle

16965391


check buttonFusion gene breakpoints across SCRIB (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across NRBP2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LGGTCGA-HT-A5RC-01ASCRIBchr8

144897383

-NRBP2chr8

144922400

-
ChimerDB4LGGTCGA-HT-A5RC-01ASCRIBchr8

144897384

-NRBP2chr8

144922401

-
ChimerDB4LGGTCGA-HT-A5RCSCRIBchr8

144897384

-NRBP2chr8

144922401

-


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Fusion Gene ORF analysis for SCRIB-NRBP2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000320476ENST00000327830SCRIBchr8

144897383

-NRBP2chr8

144922400

-
5CDS-5UTRENST00000320476ENST00000327830SCRIBchr8

144897384

-NRBP2chr8

144922401

-
5CDS-5UTRENST00000356994ENST00000327830SCRIBchr8

144897383

-NRBP2chr8

144922400

-
5CDS-5UTRENST00000356994ENST00000327830SCRIBchr8

144897384

-NRBP2chr8

144922401

-
In-frameENST00000320476ENST00000442628SCRIBchr8

144897383

-NRBP2chr8

144922400

-
In-frameENST00000320476ENST00000442628SCRIBchr8

144897384

-NRBP2chr8

144922401

-
In-frameENST00000356994ENST00000442628SCRIBchr8

144897383

-NRBP2chr8

144922400

-
In-frameENST00000356994ENST00000442628SCRIBchr8

144897384

-NRBP2chr8

144922401

-
intron-3CDSENST00000377533ENST00000442628SCRIBchr8

144897383

-NRBP2chr8

144922400

-
intron-3CDSENST00000377533ENST00000442628SCRIBchr8

144897384

-NRBP2chr8

144922401

-
intron-3CDSENST00000546337ENST00000442628SCRIBchr8

144897383

-NRBP2chr8

144922400

-
intron-3CDSENST00000546337ENST00000442628SCRIBchr8

144897384

-NRBP2chr8

144922401

-
intron-5UTRENST00000377533ENST00000327830SCRIBchr8

144897383

-NRBP2chr8

144922400

-
intron-5UTRENST00000377533ENST00000327830SCRIBchr8

144897384

-NRBP2chr8

144922401

-
intron-5UTRENST00000546337ENST00000327830SCRIBchr8

144897383

-NRBP2chr8

144922400

-
intron-5UTRENST00000546337ENST00000327830SCRIBchr8

144897384

-NRBP2chr8

144922401

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for SCRIB-NRBP2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for SCRIB-NRBP2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr8:144897384/chr8:144922401)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.NRBP2

Q9NSY0

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: May regulate apoptosis of neural progenitor cells during their differentiation. {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSCRIBchr8:144897383chr8:144922400ENST00000320476-1361379_1419531631.0Coiled coilOntology_term=ECO:0000255
HgeneSCRIBchr8:144897383chr8:144922400ENST00000320476-136458_474531631.0Coiled coilOntology_term=ECO:0000255
HgeneSCRIBchr8:144897383chr8:144922400ENST00000320476-136656_701531631.0Coiled coilOntology_term=ECO:0000255
HgeneSCRIBchr8:144897383chr8:144922400ENST00000356994-1371379_1419531656.0Coiled coilOntology_term=ECO:0000255
HgeneSCRIBchr8:144897383chr8:144922400ENST00000356994-137458_474531656.0Coiled coilOntology_term=ECO:0000255
HgeneSCRIBchr8:144897383chr8:144922400ENST00000356994-137656_701531656.0Coiled coilOntology_term=ECO:0000255
HgeneSCRIBchr8:144897383chr8:144922400ENST00000377533-1361379_141901550.0Coiled coilOntology_term=ECO:0000255
HgeneSCRIBchr8:144897383chr8:144922400ENST00000377533-136458_47401550.0Coiled coilOntology_term=ECO:0000255
HgeneSCRIBchr8:144897383chr8:144922400ENST00000377533-136656_70101550.0Coiled coilOntology_term=ECO:0000255
HgeneSCRIBchr8:144897384chr8:144922401ENST00000320476-1361379_1419531631.0Coiled coilOntology_term=ECO:0000255
HgeneSCRIBchr8:144897384chr8:144922401ENST00000320476-136458_474531631.0Coiled coilOntology_term=ECO:0000255
HgeneSCRIBchr8:144897384chr8:144922401ENST00000320476-136656_701531631.0Coiled coilOntology_term=ECO:0000255
HgeneSCRIBchr8:144897384chr8:144922401ENST00000356994-1371379_1419531656.0Coiled coilOntology_term=ECO:0000255
HgeneSCRIBchr8:144897384chr8:144922401ENST00000356994-137458_474531656.0Coiled coilOntology_term=ECO:0000255
HgeneSCRIBchr8:144897384chr8:144922401ENST00000356994-137656_701531656.0Coiled coilOntology_term=ECO:0000255
HgeneSCRIBchr8:144897384chr8:144922401ENST00000377533-1361379_141901550.0Coiled coilOntology_term=ECO:0000255
HgeneSCRIBchr8:144897384chr8:144922401ENST00000377533-136458_47401550.0Coiled coilOntology_term=ECO:0000255
HgeneSCRIBchr8:144897384chr8:144922401ENST00000377533-136656_70101550.0Coiled coilOntology_term=ECO:0000255
HgeneSCRIBchr8:144897383chr8:144922400ENST00000320476-1361296_1349531631.0Compositional biasNote=Pro-rich
HgeneSCRIBchr8:144897383chr8:144922400ENST00000320476-136660_695531631.0Compositional biasNote=Glu-rich
HgeneSCRIBchr8:144897383chr8:144922400ENST00000356994-1371296_1349531656.0Compositional biasNote=Pro-rich
HgeneSCRIBchr8:144897383chr8:144922400ENST00000356994-137660_695531656.0Compositional biasNote=Glu-rich
HgeneSCRIBchr8:144897383chr8:144922400ENST00000377533-1361296_134901550.0Compositional biasNote=Pro-rich
HgeneSCRIBchr8:144897383chr8:144922400ENST00000377533-136660_69501550.0Compositional biasNote=Glu-rich
HgeneSCRIBchr8:144897384chr8:144922401ENST00000320476-1361296_1349531631.0Compositional biasNote=Pro-rich
HgeneSCRIBchr8:144897384chr8:144922401ENST00000320476-136660_695531631.0Compositional biasNote=Glu-rich
HgeneSCRIBchr8:144897384chr8:144922401ENST00000356994-1371296_1349531656.0Compositional biasNote=Pro-rich
HgeneSCRIBchr8:144897384chr8:144922401ENST00000356994-137660_695531656.0Compositional biasNote=Glu-rich
HgeneSCRIBchr8:144897384chr8:144922401ENST00000377533-1361296_134901550.0Compositional biasNote=Pro-rich
HgeneSCRIBchr8:144897384chr8:144922401ENST00000377533-136660_69501550.0Compositional biasNote=Glu-rich
HgeneSCRIBchr8:144897383chr8:144922400ENST00000320476-1361004_1093531631.0DomainPDZ 3
HgeneSCRIBchr8:144897383chr8:144922400ENST00000320476-1361100_1194531631.0DomainPDZ 4
HgeneSCRIBchr8:144897383chr8:144922400ENST00000320476-136728_815531631.0DomainPDZ 1
HgeneSCRIBchr8:144897383chr8:144922400ENST00000320476-136862_950531631.0DomainPDZ 2
HgeneSCRIBchr8:144897383chr8:144922400ENST00000356994-1371004_1093531656.0DomainPDZ 3
HgeneSCRIBchr8:144897383chr8:144922400ENST00000356994-1371100_1194531656.0DomainPDZ 4
HgeneSCRIBchr8:144897383chr8:144922400ENST00000356994-137728_815531656.0DomainPDZ 1
HgeneSCRIBchr8:144897383chr8:144922400ENST00000356994-137862_950531656.0DomainPDZ 2
HgeneSCRIBchr8:144897383chr8:144922400ENST00000377533-1361004_109301550.0DomainPDZ 3
HgeneSCRIBchr8:144897383chr8:144922400ENST00000377533-1361100_119401550.0DomainPDZ 4
HgeneSCRIBchr8:144897383chr8:144922400ENST00000377533-136728_81501550.0DomainPDZ 1
HgeneSCRIBchr8:144897383chr8:144922400ENST00000377533-136862_95001550.0DomainPDZ 2
HgeneSCRIBchr8:144897384chr8:144922401ENST00000320476-1361004_1093531631.0DomainPDZ 3
HgeneSCRIBchr8:144897384chr8:144922401ENST00000320476-1361100_1194531631.0DomainPDZ 4
HgeneSCRIBchr8:144897384chr8:144922401ENST00000320476-136728_815531631.0DomainPDZ 1
HgeneSCRIBchr8:144897384chr8:144922401ENST00000320476-136862_950531631.0DomainPDZ 2
HgeneSCRIBchr8:144897384chr8:144922401ENST00000356994-1371004_1093531656.0DomainPDZ 3
HgeneSCRIBchr8:144897384chr8:144922401ENST00000356994-1371100_1194531656.0DomainPDZ 4
HgeneSCRIBchr8:144897384chr8:144922401ENST00000356994-137728_815531656.0DomainPDZ 1
HgeneSCRIBchr8:144897384chr8:144922401ENST00000356994-137862_950531656.0DomainPDZ 2
HgeneSCRIBchr8:144897384chr8:144922401ENST00000377533-1361004_109301550.0DomainPDZ 3
HgeneSCRIBchr8:144897384chr8:144922401ENST00000377533-1361100_119401550.0DomainPDZ 4
HgeneSCRIBchr8:144897384chr8:144922401ENST00000377533-136728_81501550.0DomainPDZ 1
HgeneSCRIBchr8:144897384chr8:144922401ENST00000377533-136862_95001550.0DomainPDZ 2
HgeneSCRIBchr8:144897383chr8:144922400ENST00000320476-1361_818531631.0RegionNote=Sufficient for targeting to adherens junction and to inhibit cell proliferation
HgeneSCRIBchr8:144897383chr8:144922400ENST00000356994-1371_818531656.0RegionNote=Sufficient for targeting to adherens junction and to inhibit cell proliferation
HgeneSCRIBchr8:144897383chr8:144922400ENST00000377533-1361_81801550.0RegionNote=Sufficient for targeting to adherens junction and to inhibit cell proliferation
HgeneSCRIBchr8:144897384chr8:144922401ENST00000320476-1361_818531631.0RegionNote=Sufficient for targeting to adherens junction and to inhibit cell proliferation
HgeneSCRIBchr8:144897384chr8:144922401ENST00000356994-1371_818531656.0RegionNote=Sufficient for targeting to adherens junction and to inhibit cell proliferation
HgeneSCRIBchr8:144897384chr8:144922401ENST00000377533-1361_81801550.0RegionNote=Sufficient for targeting to adherens junction and to inhibit cell proliferation
HgeneSCRIBchr8:144897383chr8:144922400ENST00000320476-136106_127531631.0RepeatNote=LRR 4
HgeneSCRIBchr8:144897383chr8:144922400ENST00000320476-136129_150531631.0RepeatNote=LRR 5
HgeneSCRIBchr8:144897383chr8:144922400ENST00000320476-136152_174531631.0RepeatNote=LRR 6
HgeneSCRIBchr8:144897383chr8:144922400ENST00000320476-136175_197531631.0RepeatNote=LRR 7
HgeneSCRIBchr8:144897383chr8:144922400ENST00000320476-136198_219531631.0RepeatNote=LRR 8
HgeneSCRIBchr8:144897383chr8:144922400ENST00000320476-136221_243531631.0RepeatNote=LRR 9
HgeneSCRIBchr8:144897383chr8:144922400ENST00000320476-136244_265531631.0RepeatNote=LRR 10
HgeneSCRIBchr8:144897383chr8:144922400ENST00000320476-136267_288531631.0RepeatNote=LRR 11
HgeneSCRIBchr8:144897383chr8:144922400ENST00000320476-136290_312531631.0RepeatNote=LRR 12
HgeneSCRIBchr8:144897383chr8:144922400ENST00000320476-136313_334531631.0RepeatNote=LRR 13
HgeneSCRIBchr8:144897383chr8:144922400ENST00000320476-136336_357531631.0RepeatNote=LRR 14
HgeneSCRIBchr8:144897383chr8:144922400ENST00000320476-136359_381531631.0RepeatNote=LRR 15
HgeneSCRIBchr8:144897383chr8:144922400ENST00000320476-13637_58531631.0RepeatNote=LRR 1
HgeneSCRIBchr8:144897383chr8:144922400ENST00000320476-136382_402531631.0RepeatNote=LRR 16
HgeneSCRIBchr8:144897383chr8:144922400ENST00000320476-13660_81531631.0RepeatNote=LRR 2
HgeneSCRIBchr8:144897383chr8:144922400ENST00000320476-13683_104531631.0RepeatNote=LRR 3
HgeneSCRIBchr8:144897383chr8:144922400ENST00000356994-137106_127531656.0RepeatNote=LRR 4
HgeneSCRIBchr8:144897383chr8:144922400ENST00000356994-137129_150531656.0RepeatNote=LRR 5
HgeneSCRIBchr8:144897383chr8:144922400ENST00000356994-137152_174531656.0RepeatNote=LRR 6
HgeneSCRIBchr8:144897383chr8:144922400ENST00000356994-137175_197531656.0RepeatNote=LRR 7
HgeneSCRIBchr8:144897383chr8:144922400ENST00000356994-137198_219531656.0RepeatNote=LRR 8
HgeneSCRIBchr8:144897383chr8:144922400ENST00000356994-137221_243531656.0RepeatNote=LRR 9
HgeneSCRIBchr8:144897383chr8:144922400ENST00000356994-137244_265531656.0RepeatNote=LRR 10
HgeneSCRIBchr8:144897383chr8:144922400ENST00000356994-137267_288531656.0RepeatNote=LRR 11
HgeneSCRIBchr8:144897383chr8:144922400ENST00000356994-137290_312531656.0RepeatNote=LRR 12
HgeneSCRIBchr8:144897383chr8:144922400ENST00000356994-137313_334531656.0RepeatNote=LRR 13
HgeneSCRIBchr8:144897383chr8:144922400ENST00000356994-137336_357531656.0RepeatNote=LRR 14
HgeneSCRIBchr8:144897383chr8:144922400ENST00000356994-137359_381531656.0RepeatNote=LRR 15
HgeneSCRIBchr8:144897383chr8:144922400ENST00000356994-13737_58531656.0RepeatNote=LRR 1
HgeneSCRIBchr8:144897383chr8:144922400ENST00000356994-137382_402531656.0RepeatNote=LRR 16
HgeneSCRIBchr8:144897383chr8:144922400ENST00000356994-13760_81531656.0RepeatNote=LRR 2
HgeneSCRIBchr8:144897383chr8:144922400ENST00000356994-13783_104531656.0RepeatNote=LRR 3
HgeneSCRIBchr8:144897383chr8:144922400ENST00000377533-136106_12701550.0RepeatNote=LRR 4
HgeneSCRIBchr8:144897383chr8:144922400ENST00000377533-136129_15001550.0RepeatNote=LRR 5
HgeneSCRIBchr8:144897383chr8:144922400ENST00000377533-136152_17401550.0RepeatNote=LRR 6
HgeneSCRIBchr8:144897383chr8:144922400ENST00000377533-136175_19701550.0RepeatNote=LRR 7
HgeneSCRIBchr8:144897383chr8:144922400ENST00000377533-136198_21901550.0RepeatNote=LRR 8
HgeneSCRIBchr8:144897383chr8:144922400ENST00000377533-136221_24301550.0RepeatNote=LRR 9
HgeneSCRIBchr8:144897383chr8:144922400ENST00000377533-136244_26501550.0RepeatNote=LRR 10
HgeneSCRIBchr8:144897383chr8:144922400ENST00000377533-136267_28801550.0RepeatNote=LRR 11
HgeneSCRIBchr8:144897383chr8:144922400ENST00000377533-136290_31201550.0RepeatNote=LRR 12
HgeneSCRIBchr8:144897383chr8:144922400ENST00000377533-136313_33401550.0RepeatNote=LRR 13
HgeneSCRIBchr8:144897383chr8:144922400ENST00000377533-136336_35701550.0RepeatNote=LRR 14
HgeneSCRIBchr8:144897383chr8:144922400ENST00000377533-136359_38101550.0RepeatNote=LRR 15
HgeneSCRIBchr8:144897383chr8:144922400ENST00000377533-13637_5801550.0RepeatNote=LRR 1
HgeneSCRIBchr8:144897383chr8:144922400ENST00000377533-136382_40201550.0RepeatNote=LRR 16
HgeneSCRIBchr8:144897383chr8:144922400ENST00000377533-13660_8101550.0RepeatNote=LRR 2
HgeneSCRIBchr8:144897383chr8:144922400ENST00000377533-13683_10401550.0RepeatNote=LRR 3
HgeneSCRIBchr8:144897384chr8:144922401ENST00000320476-136106_127531631.0RepeatNote=LRR 4
HgeneSCRIBchr8:144897384chr8:144922401ENST00000320476-136129_150531631.0RepeatNote=LRR 5
HgeneSCRIBchr8:144897384chr8:144922401ENST00000320476-136152_174531631.0RepeatNote=LRR 6
HgeneSCRIBchr8:144897384chr8:144922401ENST00000320476-136175_197531631.0RepeatNote=LRR 7
HgeneSCRIBchr8:144897384chr8:144922401ENST00000320476-136198_219531631.0RepeatNote=LRR 8
HgeneSCRIBchr8:144897384chr8:144922401ENST00000320476-136221_243531631.0RepeatNote=LRR 9
HgeneSCRIBchr8:144897384chr8:144922401ENST00000320476-136244_265531631.0RepeatNote=LRR 10
HgeneSCRIBchr8:144897384chr8:144922401ENST00000320476-136267_288531631.0RepeatNote=LRR 11
HgeneSCRIBchr8:144897384chr8:144922401ENST00000320476-136290_312531631.0RepeatNote=LRR 12
HgeneSCRIBchr8:144897384chr8:144922401ENST00000320476-136313_334531631.0RepeatNote=LRR 13
HgeneSCRIBchr8:144897384chr8:144922401ENST00000320476-136336_357531631.0RepeatNote=LRR 14
HgeneSCRIBchr8:144897384chr8:144922401ENST00000320476-136359_381531631.0RepeatNote=LRR 15
HgeneSCRIBchr8:144897384chr8:144922401ENST00000320476-13637_58531631.0RepeatNote=LRR 1
HgeneSCRIBchr8:144897384chr8:144922401ENST00000320476-136382_402531631.0RepeatNote=LRR 16
HgeneSCRIBchr8:144897384chr8:144922401ENST00000320476-13660_81531631.0RepeatNote=LRR 2
HgeneSCRIBchr8:144897384chr8:144922401ENST00000320476-13683_104531631.0RepeatNote=LRR 3
HgeneSCRIBchr8:144897384chr8:144922401ENST00000356994-137106_127531656.0RepeatNote=LRR 4
HgeneSCRIBchr8:144897384chr8:144922401ENST00000356994-137129_150531656.0RepeatNote=LRR 5
HgeneSCRIBchr8:144897384chr8:144922401ENST00000356994-137152_174531656.0RepeatNote=LRR 6
HgeneSCRIBchr8:144897384chr8:144922401ENST00000356994-137175_197531656.0RepeatNote=LRR 7
HgeneSCRIBchr8:144897384chr8:144922401ENST00000356994-137198_219531656.0RepeatNote=LRR 8
HgeneSCRIBchr8:144897384chr8:144922401ENST00000356994-137221_243531656.0RepeatNote=LRR 9
HgeneSCRIBchr8:144897384chr8:144922401ENST00000356994-137244_265531656.0RepeatNote=LRR 10
HgeneSCRIBchr8:144897384chr8:144922401ENST00000356994-137267_288531656.0RepeatNote=LRR 11
HgeneSCRIBchr8:144897384chr8:144922401ENST00000356994-137290_312531656.0RepeatNote=LRR 12
HgeneSCRIBchr8:144897384chr8:144922401ENST00000356994-137313_334531656.0RepeatNote=LRR 13
HgeneSCRIBchr8:144897384chr8:144922401ENST00000356994-137336_357531656.0RepeatNote=LRR 14
HgeneSCRIBchr8:144897384chr8:144922401ENST00000356994-137359_381531656.0RepeatNote=LRR 15
HgeneSCRIBchr8:144897384chr8:144922401ENST00000356994-13737_58531656.0RepeatNote=LRR 1
HgeneSCRIBchr8:144897384chr8:144922401ENST00000356994-137382_402531656.0RepeatNote=LRR 16
HgeneSCRIBchr8:144897384chr8:144922401ENST00000356994-13760_81531656.0RepeatNote=LRR 2
HgeneSCRIBchr8:144897384chr8:144922401ENST00000356994-13783_104531656.0RepeatNote=LRR 3
HgeneSCRIBchr8:144897384chr8:144922401ENST00000377533-136106_12701550.0RepeatNote=LRR 4
HgeneSCRIBchr8:144897384chr8:144922401ENST00000377533-136129_15001550.0RepeatNote=LRR 5
HgeneSCRIBchr8:144897384chr8:144922401ENST00000377533-136152_17401550.0RepeatNote=LRR 6
HgeneSCRIBchr8:144897384chr8:144922401ENST00000377533-136175_19701550.0RepeatNote=LRR 7
HgeneSCRIBchr8:144897384chr8:144922401ENST00000377533-136198_21901550.0RepeatNote=LRR 8
HgeneSCRIBchr8:144897384chr8:144922401ENST00000377533-136221_24301550.0RepeatNote=LRR 9
HgeneSCRIBchr8:144897384chr8:144922401ENST00000377533-136244_26501550.0RepeatNote=LRR 10
HgeneSCRIBchr8:144897384chr8:144922401ENST00000377533-136267_28801550.0RepeatNote=LRR 11
HgeneSCRIBchr8:144897384chr8:144922401ENST00000377533-136290_31201550.0RepeatNote=LRR 12
HgeneSCRIBchr8:144897384chr8:144922401ENST00000377533-136313_33401550.0RepeatNote=LRR 13
HgeneSCRIBchr8:144897384chr8:144922401ENST00000377533-136336_35701550.0RepeatNote=LRR 14
HgeneSCRIBchr8:144897384chr8:144922401ENST00000377533-136359_38101550.0RepeatNote=LRR 15
HgeneSCRIBchr8:144897384chr8:144922401ENST00000377533-13637_5801550.0RepeatNote=LRR 1
HgeneSCRIBchr8:144897384chr8:144922401ENST00000377533-136382_40201550.0RepeatNote=LRR 16
HgeneSCRIBchr8:144897384chr8:144922401ENST00000377533-13660_8101550.0RepeatNote=LRR 2
HgeneSCRIBchr8:144897384chr8:144922401ENST00000377533-13683_10401550.0RepeatNote=LRR 3
TgeneNRBP2chr8:144897383chr8:144922400ENST0000044262801838_30643502.0DomainProtein kinase
TgeneNRBP2chr8:144897384chr8:144922401ENST0000044262801838_30643502.0DomainProtein kinase


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Fusion Gene Sequence for SCRIB-NRBP2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for SCRIB-NRBP2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneSCRIBchr8:144897383chr8:144922400ENST00000320476-136717_122953.01631.0ARHGEF7
HgeneSCRIBchr8:144897383chr8:144922400ENST00000356994-137717_122953.01656.0ARHGEF7
HgeneSCRIBchr8:144897383chr8:144922400ENST00000377533-136717_122901550.0ARHGEF7
HgeneSCRIBchr8:144897384chr8:144922401ENST00000320476-136717_122953.01631.0ARHGEF7
HgeneSCRIBchr8:144897384chr8:144922401ENST00000356994-137717_122953.01656.0ARHGEF7
HgeneSCRIBchr8:144897384chr8:144922401ENST00000377533-136717_122901550.0ARHGEF7
HgeneSCRIBchr8:144897383chr8:144922400ENST00000320476-1361105_111753.01631.0tick-borne encephalitis virus RNA-directed RNA polymerase NS5
HgeneSCRIBchr8:144897383chr8:144922400ENST00000356994-1371105_111753.01656.0tick-borne encephalitis virus RNA-directed RNA polymerase NS5
HgeneSCRIBchr8:144897383chr8:144922400ENST00000377533-1361105_111701550.0tick-borne encephalitis virus RNA-directed RNA polymerase NS5
HgeneSCRIBchr8:144897384chr8:144922401ENST00000320476-1361105_111753.01631.0tick-borne encephalitis virus RNA-directed RNA polymerase NS5
HgeneSCRIBchr8:144897384chr8:144922401ENST00000356994-1371105_111753.01656.0tick-borne encephalitis virus RNA-directed RNA polymerase NS5
HgeneSCRIBchr8:144897384chr8:144922401ENST00000377533-1361105_111701550.0tick-borne encephalitis virus RNA-directed RNA polymerase NS5


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for SCRIB-NRBP2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for SCRIB-NRBP2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource