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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:SCUBE2-DENND5A (FusionGDB2 ID:79753)

Fusion Gene Summary for SCUBE2-DENND5A

check button Fusion gene summary
Fusion gene informationFusion gene name: SCUBE2-DENND5A
Fusion gene ID: 79753
HgeneTgene
Gene symbol

SCUBE2

DENND5A

Gene ID

57758

23258

Gene namesignal peptide, CUB domain and EGF like domain containing 2DENN domain containing 5A
SynonymsCEGB1|CEGF1|CEGP1|scube/YouEIEE49|RAB6IP1
Cytomap

11p15.4

11p15.4

Type of geneprotein-codingprotein-coding
Descriptionsignal peptide, CUB and EGF-like domain-containing protein 2DENN domain-containing protein 5ADENN/MADD domain containing 5ARAB6 interacting protein 1rab6-interacting protein 1
Modification date2020031320200313
UniProtAcc.

Q6IQ26

Ensembl transtripts involved in fusion geneENST00000309263, ENST00000450649, 
ENST00000457346, ENST00000520467, 
ENST00000534295, 		ENST00000527700, 
ENST00000526523, ENST00000328194, 
ENST00000530044, 
Fusion gene scores* DoF score6 X 6 X 4=14415 X 15 X 6=1350
# samples 616
** MAII scorelog2(6/144*10)=-1.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(16/1350*10)=-3.07681559705083
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SCUBE2 [Title/Abstract] AND DENND5A [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointDENND5A(9286508)-SCUBE2(9144441), # samples:2
DENND5A(9171628)-SCUBE2(9043502), # samples:2
SCUBE2(9087438)-DENND5A(9192324), # samples:1
Anticipated loss of major functional domain due to fusion event.DENND5A-SCUBE2 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
DENND5A-SCUBE2 seems lost the major protein functional domain in Tgene partner, which is a tumor suppressor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across SCUBE2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across DENND5A (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-D8-A27R-01ASCUBE2chr11

9087438

-DENND5Achr11

9192324

-


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Fusion Gene ORF analysis for SCUBE2-DENND5A

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000309263ENST00000527700SCUBE2chr11

9087438

-DENND5Achr11

9192324

-
5CDS-5UTRENST00000450649ENST00000527700SCUBE2chr11

9087438

-DENND5Achr11

9192324

-
5CDS-5UTRENST00000457346ENST00000527700SCUBE2chr11

9087438

-DENND5Achr11

9192324

-
5CDS-5UTRENST00000520467ENST00000527700SCUBE2chr11

9087438

-DENND5Achr11

9192324

-
5CDS-intronENST00000309263ENST00000526523SCUBE2chr11

9087438

-DENND5Achr11

9192324

-
5CDS-intronENST00000450649ENST00000526523SCUBE2chr11

9087438

-DENND5Achr11

9192324

-
5CDS-intronENST00000457346ENST00000526523SCUBE2chr11

9087438

-DENND5Achr11

9192324

-
5CDS-intronENST00000520467ENST00000526523SCUBE2chr11

9087438

-DENND5Achr11

9192324

-
In-frameENST00000309263ENST00000328194SCUBE2chr11

9087438

-DENND5Achr11

9192324

-
In-frameENST00000309263ENST00000530044SCUBE2chr11

9087438

-DENND5Achr11

9192324

-
In-frameENST00000450649ENST00000328194SCUBE2chr11

9087438

-DENND5Achr11

9192324

-
In-frameENST00000450649ENST00000530044SCUBE2chr11

9087438

-DENND5Achr11

9192324

-
In-frameENST00000457346ENST00000328194SCUBE2chr11

9087438

-DENND5Achr11

9192324

-
In-frameENST00000457346ENST00000530044SCUBE2chr11

9087438

-DENND5Achr11

9192324

-
In-frameENST00000520467ENST00000328194SCUBE2chr11

9087438

-DENND5Achr11

9192324

-
In-frameENST00000520467ENST00000530044SCUBE2chr11

9087438

-DENND5Achr11

9192324

-
intron-3CDSENST00000534295ENST00000328194SCUBE2chr11

9087438

-DENND5Achr11

9192324

-
intron-3CDSENST00000534295ENST00000530044SCUBE2chr11

9087438

-DENND5Achr11

9192324

-
intron-5UTRENST00000534295ENST00000527700SCUBE2chr11

9087438

-DENND5Achr11

9192324

-
intron-intronENST00000534295ENST00000526523SCUBE2chr11

9087438

-DENND5Achr11

9192324

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000457346SCUBE2chr119087438-ENST00000328194DENND5Achr119192324-3729925512882943
ENST00000457346SCUBE2chr119087438-ENST00000530044DENND5Achr119192324-3061925512744897
ENST00000309263SCUBE2chr119087438-ENST00000328194DENND5Achr119192324-3727923492880943
ENST00000309263SCUBE2chr119087438-ENST00000530044DENND5Achr119192324-3059923492742897
ENST00000450649SCUBE2chr119087438-ENST00000328194DENND5Achr119192324-3672868182825935
ENST00000450649SCUBE2chr119087438-ENST00000530044DENND5Achr119192324-3004868182687889
ENST00000520467SCUBE2chr119087438-ENST00000328194DENND5Achr119192324-3725921472878943
ENST00000520467SCUBE2chr119087438-ENST00000530044DENND5Achr119192324-3057921472740897

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000457346ENST00000328194SCUBE2chr119087438-DENND5Achr119192324-0.0024215330.99757844
ENST00000457346ENST00000530044SCUBE2chr119087438-DENND5Achr119192324-0.0069302850.9930697
ENST00000309263ENST00000328194SCUBE2chr119087438-DENND5Achr119192324-0.0024281130.9975719
ENST00000309263ENST00000530044SCUBE2chr119087438-DENND5Achr119192324-0.0069432860.99305665
ENST00000450649ENST00000328194SCUBE2chr119087438-DENND5Achr119192324-0.0023385560.9976615
ENST00000450649ENST00000530044SCUBE2chr119087438-DENND5Achr119192324-0.0070542530.99294573
ENST00000520467ENST00000328194SCUBE2chr119087438-DENND5Achr119192324-0.0024540140.997546
ENST00000520467ENST00000530044SCUBE2chr119087438-DENND5Achr119192324-0.006985040.99301493

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Fusion Genomic Features for SCUBE2-DENND5A


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for SCUBE2-DENND5A


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr11:9286508/chr11:9144441)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.DENND5A

Q6IQ26

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Guanine nucleotide exchange factor (GEF) which may activate RAB6A and RAB39A and/or RAB39B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. Involved in the negative regulation of neurite outgrowth (By similarity). {ECO:0000250|UniProtKB:G3V7Q0, ECO:0000269|PubMed:20937701}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSCUBE2chr11:9087438chr11:9192324ENST00000309263-722128_1682831000.0DomainEGF-like 3%3B calcium-binding
HgeneSCUBE2chr11:9087438chr11:9192324ENST00000309263-722177_2132831000.0DomainEGF-like 4
HgeneSCUBE2chr11:9087438chr11:9192324ENST00000309263-722217_2522831000.0DomainEGF-like 5
HgeneSCUBE2chr11:9087438chr11:9192324ENST00000309263-72245_852831000.0DomainEGF-like 1%3B calcium-binding
HgeneSCUBE2chr11:9087438chr11:9192324ENST00000309263-72286_1272831000.0DomainEGF-like 2%3B calcium-binding
HgeneSCUBE2chr11:9087438chr11:9192324ENST00000450649-718128_168283808.0DomainEGF-like 3%3B calcium-binding
HgeneSCUBE2chr11:9087438chr11:9192324ENST00000450649-718177_213283808.0DomainEGF-like 4
HgeneSCUBE2chr11:9087438chr11:9192324ENST00000450649-718217_252283808.0DomainEGF-like 5
HgeneSCUBE2chr11:9087438chr11:9192324ENST00000450649-71845_85283808.0DomainEGF-like 1%3B calcium-binding
HgeneSCUBE2chr11:9087438chr11:9192324ENST00000450649-71886_127283808.0DomainEGF-like 2%3B calcium-binding
HgeneSCUBE2chr11:9087438chr11:9192324ENST00000520467-722128_168283972.0DomainEGF-like 3%3B calcium-binding
HgeneSCUBE2chr11:9087438chr11:9192324ENST00000520467-722177_213283972.0DomainEGF-like 4
HgeneSCUBE2chr11:9087438chr11:9192324ENST00000520467-722217_252283972.0DomainEGF-like 5
HgeneSCUBE2chr11:9087438chr11:9192324ENST00000520467-72245_85283972.0DomainEGF-like 1%3B calcium-binding
HgeneSCUBE2chr11:9087438chr11:9192324ENST00000520467-72286_127283972.0DomainEGF-like 2%3B calcium-binding
TgeneDENND5Achr11:9087438chr11:9192324ENST000003281947231134_12826351288.0DomainRUN 2
TgeneDENND5Achr11:9087438chr11:9192324ENST00000328194723787_9506351288.0DomainRUN 1
TgeneDENND5Achr11:9087438chr11:9192324ENST00000328194723954_10626351288.0DomainPLAT
TgeneDENND5Achr11:9087438chr11:9192324ENST000005300447231134_12826351242.0DomainRUN 2
TgeneDENND5Achr11:9087438chr11:9192324ENST00000530044723787_9506351242.0DomainRUN 1
TgeneDENND5Achr11:9087438chr11:9192324ENST00000530044723954_10626351242.0DomainPLAT

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSCUBE2chr11:9087438chr11:9192324ENST00000309263-722286_3212831000.0DomainEGF-like 6
HgeneSCUBE2chr11:9087438chr11:9192324ENST00000309263-722323_3632831000.0DomainEGF-like 7%3B calcium-binding
HgeneSCUBE2chr11:9087438chr11:9192324ENST00000309263-722364_4022831000.0DomainEGF-like 8%3B calcium-binding
HgeneSCUBE2chr11:9087438chr11:9192324ENST00000309263-722403_4432831000.0DomainEGF-like 9%3B calcium-binding
HgeneSCUBE2chr11:9087438chr11:9192324ENST00000309263-722809_9212831000.0DomainCUB
HgeneSCUBE2chr11:9087438chr11:9192324ENST00000450649-718286_321283808.0DomainEGF-like 6
HgeneSCUBE2chr11:9087438chr11:9192324ENST00000450649-718323_363283808.0DomainEGF-like 7%3B calcium-binding
HgeneSCUBE2chr11:9087438chr11:9192324ENST00000450649-718364_402283808.0DomainEGF-like 8%3B calcium-binding
HgeneSCUBE2chr11:9087438chr11:9192324ENST00000450649-718403_443283808.0DomainEGF-like 9%3B calcium-binding
HgeneSCUBE2chr11:9087438chr11:9192324ENST00000450649-718809_921283808.0DomainCUB
HgeneSCUBE2chr11:9087438chr11:9192324ENST00000520467-722286_321283972.0DomainEGF-like 6
HgeneSCUBE2chr11:9087438chr11:9192324ENST00000520467-722323_363283972.0DomainEGF-like 7%3B calcium-binding
HgeneSCUBE2chr11:9087438chr11:9192324ENST00000520467-722364_402283972.0DomainEGF-like 8%3B calcium-binding
HgeneSCUBE2chr11:9087438chr11:9192324ENST00000520467-722403_443283972.0DomainEGF-like 9%3B calcium-binding
HgeneSCUBE2chr11:9087438chr11:9192324ENST00000520467-722809_921283972.0DomainCUB
TgeneDENND5Achr11:9087438chr11:9192324ENST000003281947233_96351288.0Compositional biasNote=Poly-Gly
TgeneDENND5Achr11:9087438chr11:9192324ENST00000328194723593_5986351288.0Compositional biasNote=Poly-Asp
TgeneDENND5Achr11:9087438chr11:9192324ENST000005300447233_96351242.0Compositional biasNote=Poly-Gly
TgeneDENND5Achr11:9087438chr11:9192324ENST00000530044723593_5986351242.0Compositional biasNote=Poly-Asp
TgeneDENND5Achr11:9087438chr11:9192324ENST00000328194723278_4146351288.0DomaincDENN
TgeneDENND5Achr11:9087438chr11:9192324ENST00000328194723416_5986351288.0DomaindDENN
TgeneDENND5Achr11:9087438chr11:9192324ENST0000032819472357_2596351288.0DomainuDENN
TgeneDENND5Achr11:9087438chr11:9192324ENST00000530044723278_4146351242.0DomaincDENN
TgeneDENND5Achr11:9087438chr11:9192324ENST00000530044723416_5986351242.0DomaindDENN
TgeneDENND5Achr11:9087438chr11:9192324ENST0000053004472357_2596351242.0DomainuDENN


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Fusion Gene Sequence for SCUBE2-DENND5A


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>79753_79753_1_SCUBE2-DENND5A_SCUBE2_chr11_9087438_ENST00000309263_DENND5A_chr11_9192324_ENST00000328194_length(transcript)=3727nt_BP=923nt
GCGCACACCTCCCCGCGCCGCCGCCGCCACCGCCCGCACTCCGCCGCCTCTGCCCGCAACCGCTGAGCCATCCATGGGGGTCGCGGGCCG
CAACCGTCCCGGGGCGGCCTGGGCGGTGCTGCTGCTGCTGCTGCTGCTGCCGCCACTGCTGCTGCTGGCGGGGGCCGTCCCGCCGGGTCG
GGGCCGTGCCGCGGGGCCGCAGGAGGATGTAGATGAGTGTGCCCAAGGGCTAGATGACTGCCATGCCGACGCCCTGTGTCAGAACACACC
CACCTCCTACAAGTGCTCCTGCAAGCCTGGCTACCAAGGGGAAGGCAGGCAGTGTGAGGACATCGATGAATGTGGAAATGAGCTCAATGG
AGGCTGTGTCCATGACTGTTTGAATATTCCAGGCAATTATCGTTGCACTTGTTTTGATGGCTTCATGTTGGCTCATGACGGTCATAATTG
TCTTGATGTGGACGAGTGCCTGGAGAACAATGGCGGCTGCCAGCATACCTGTGTCAACGTCATGGGGAGCTATGAGTGCTGCTGCAAGGA
GGGGTTTTTCCTGAGTGACAATCAGCACACCTGCATTCACCGCTCGGAAGAGGGCCTGAGCTGCATGAATAAGGATCACGGCTGTAGTCA
CATCTGCAAGGAGGCCCCAAGGGGCAGCGTCGCCTGTGAGTGCAGGCCTGGTTTTGAGCTGGCCAAGAACCAGAGAGACTGCATCTTGAC
CTGTAACCATGGGAACGGTGGGTGCCAGCACTCCTGTGACGATACAGCCGATGGCCCAGAGTGCAGCTGCCATCCACAGTACAAGATGCA
CACAGATGGGAGGAGCTGCCTTGAGCGAGAGGACACTGTCCTGGAGGTGACAGAGAGCAACACCACATCAGTGGTGGATGGGGATAAACG
GGTGAAACGGCGGCTGCTCATGGAGAAAGCAATTGAGCTGCGTCTGGCAAAAATTGACCATACTGCAATTCACCCACATTTACTTGACAT
GAAGATTGGACAAGGGAAATATGAGCCGGGCTTCTTCCCTAAGCTGCAGTCTGATGTACTTTCCACTGGGCCAGCCAGCAACAAGTGGAC
GAAAAGGAATGCCCCTGCCCAGTGGAGGCGGAAAGATCGGCAGAAGCAGCACACAGAACACCTGCGTTTAGATAATGACCAGAGGGAGAA
GTACATCCAGGAAGCCAGGACTATGGGCAGCACTATCCGCCAGCCCAAACTGTCCAACCTCTCTCCATCAGTGATTGCCCAGACCAATTG
GAAGTTTGTAGAGGGCCTGCTGAAGGAATGCCGCAATAAGACCAAGAGGATGCTGGTGGAAAAGATGGGCCGAGAAGCTGTGGAGCTAGG
GCATGGGGAGGTGAACATCACAGGGGTGGAAGAGAACACCCTGATTGCCAGCCTTTGTGATCTCCTGGAAAGGATCTGGAGTCATGGACT
ACAAGTGAAACAGGGGAAATCAGCCTTATGGTCCCACCTGTTACATTATCAGGACAACCGGCAGAGAAAACTCACATCAGGAAGCCTCAG
TACCTCAGGAATACTTCTTGATTCAGAACGTAGGAAGTCTGATGCCAGCTCACTCATGCCTCCCCTGAGGATCTCCCTGATTCAGGATAT
GAGGCACATCCAGAACATCGGGGAAATCAAGACTGATGTGGGAAAGGCCAGAGCATGGGTGCGACTGTCCATGGAAAAAAAGTTACTTTC
CAGACACCTGAAGCAGCTCCTCTCAGACCATGAGCTCACCAAAAAGTTATATAAGCGCTATGCCTTCCTGCGCTGTGATGACGAGAAGGA
GCAGTTCCTCTATCACCTCCTGTCTTTCAATGCCGTCGATTACTTTTGCTTCACCAATGTCTTCACAACTATCCTGATCCCGTACCACAT
TCTGATCGTACCAAGCAAGAAGCTGGGGGGCTCCATGTTCACTGCCAACCCATGGATCTGTATATCAGGAGAATTGGGTGAGACACAGAT
CATGCAGATTCCCAGGAATGTGCTAGAGATGACCTTCGAGTGCCAGAACTTGGGGAAGCTTACTACTGTCCAGATTGGCCATGATAACTC
TGGGCTGTATGCCAAATGGCTGGTGGAGTATGTGATGGTCAGGAATGAGATCACAGGACATACCTACAAGTTCCCGTGTGGCCGGTGGTT
AGGGAAGGGCATGGATGATGGAAGCCTGGAGCGGATCCTAGTTGGGGAGCTGCTCACATCCCAGCCTGAGGTGGATGAGAGGCCATGCCG
GACCCCGCCGCTGCAGCAGTCCCCCAGTGTCATCCGGAGGCTTGTTACCATCTCACCCAACAACAAGCCCAAGCTGAACACTGGGCAGAT
CCAGGAGTCCATCGGGGAGGCAGTCAATGGCATTGTGAAGCACTTCCATAAGCCTGAGAAAGAGCGAGGCAGTCTGACGCTGTTGCTCTG
TGGAGAGTGTGGCCTTGTCTCGGCCTTGGAACAGGCTTTCCAGCATGGATTTAAATCGCCCCGGCTCTTCAAAAATGTCTTCATTTGGGA
TTTCCTGGAAAAAGCACAAACCTATTATGAGACATTAGAGAAGAATGAAGTAGTCCCTGAGGAAAACTGGCATACAAGAGCCCGGAACTT
CTGCCGATTTGTCACTGCAATCAACAATACTCCCCGGAACATCGGCAAGGATGGCAAGTTTCAGATGCTGGTGTGCTTGGGAGCCAGAGA
TCACCTCCTACACCACTGGATTGCCCTGCTGGCTGACTGCCCCATCACTGCACACATGTATGAGGATGTGGCACTGATCAAAGACCATAC
ACTTGTCAATTCCTTGATTCGTGTGCTGCAGACATTGCAGGAGTTCAACATCACGCTGGAGACGTCCCTTGTCAAGGGCATCGACATCTG
ACCTCCCAGCACCAGCCAGCAGCAGGACTGAGAAAGACTCACCCTGCAGCTCTGACCTTTTTTCCCAAAGGGACTTAAGCGATTGTGCAG
GAGTAGGAGACAAAATGTACACTCACTGTAAAAAGAAAACTAGAGGATTTTTGGAATAAATAATCTATTTTAGAGTTTATTTGCTGATTT
GCTTTTTACACACTTTCATGTGAAAGAGTGATAGGGAGAGGGAGCGAGGCTGGTGCCGCTTATTTTGAAGCTGGTGCCCTCCCTCGCCGT
GGCCACATGCTGGAAGCCTGAGGCCTCCCTGGACTGAGCCTGTGGCACTGCGTGCGGGACAGTTATGTTTCCTTGCCCCGTCGCATTAAT
GAGGCCCTTCCACATCATTTTTAAACTAATGTTTTTCTATATTAACATTATTATGGATATTTGGCTTTCATAGGCCACACACAGGTGTGC
TGCGCGGGAAGCCCCATGCTCCAATCAAAGGGATTTTTAGTAGTGCCTCTAAGCAAGCACCGATGAGTCAGTCCCACGTATTTTCTTTTT
TGTCAGTATTGTTTGGGAAGGAGACATGCCGGGATGTGTCATCGTGCCAAATACCACATTTCCTGTTGGCACAGTTTCACAGAAGTAAAC
ATAAGCATGTTTTAACAGGTTTTTCTTTTCTTTTTTCTTTTTTAAAATGTTTTATTTATTTAACCCGCCATTGTGTGTTTTTAAGTATTT
TCTTTTTTTAAGGAAAGGAAAAGCTTGTCACAATCTAACTGGCTATGTTATTATTATTAAATTTATGTTTTGCAACTTAGAAACCAGCTA

>79753_79753_1_SCUBE2-DENND5A_SCUBE2_chr11_9087438_ENST00000309263_DENND5A_chr11_9192324_ENST00000328194_length(amino acids)=943AA_BP=291
MPATAEPSMGVAGRNRPGAAWAVLLLLLLLPPLLLLAGAVPPGRGRAAGPQEDVDECAQGLDDCHADALCQNTPTSYKCSCKPGYQGEGR
QCEDIDECGNELNGGCVHDCLNIPGNYRCTCFDGFMLAHDGHNCLDVDECLENNGGCQHTCVNVMGSYECCCKEGFFLSDNQHTCIHRSE
EGLSCMNKDHGCSHICKEAPRGSVACECRPGFELAKNQRDCILTCNHGNGGCQHSCDDTADGPECSCHPQYKMHTDGRSCLEREDTVLEV
TESNTTSVVDGDKRVKRRLLMEKAIELRLAKIDHTAIHPHLLDMKIGQGKYEPGFFPKLQSDVLSTGPASNKWTKRNAPAQWRRKDRQKQ
HTEHLRLDNDQREKYIQEARTMGSTIRQPKLSNLSPSVIAQTNWKFVEGLLKECRNKTKRMLVEKMGREAVELGHGEVNITGVEENTLIA
SLCDLLERIWSHGLQVKQGKSALWSHLLHYQDNRQRKLTSGSLSTSGILLDSERRKSDASSLMPPLRISLIQDMRHIQNIGEIKTDVGKA
RAWVRLSMEKKLLSRHLKQLLSDHELTKKLYKRYAFLRCDDEKEQFLYHLLSFNAVDYFCFTNVFTTILIPYHILIVPSKKLGGSMFTAN
PWICISGELGETQIMQIPRNVLEMTFECQNLGKLTTVQIGHDNSGLYAKWLVEYVMVRNEITGHTYKFPCGRWLGKGMDDGSLERILVGE
LLTSQPEVDERPCRTPPLQQSPSVIRRLVTISPNNKPKLNTGQIQESIGEAVNGIVKHFHKPEKERGSLTLLLCGECGLVSALEQAFQHG
FKSPRLFKNVFIWDFLEKAQTYYETLEKNEVVPEENWHTRARNFCRFVTAINNTPRNIGKDGKFQMLVCLGARDHLLHHWIALLADCPIT

--------------------------------------------------------------
>79753_79753_2_SCUBE2-DENND5A_SCUBE2_chr11_9087438_ENST00000309263_DENND5A_chr11_9192324_ENST00000530044_length(transcript)=3059nt_BP=923nt
GCGCACACCTCCCCGCGCCGCCGCCGCCACCGCCCGCACTCCGCCGCCTCTGCCCGCAACCGCTGAGCCATCCATGGGGGTCGCGGGCCG
CAACCGTCCCGGGGCGGCCTGGGCGGTGCTGCTGCTGCTGCTGCTGCTGCCGCCACTGCTGCTGCTGGCGGGGGCCGTCCCGCCGGGTCG
GGGCCGTGCCGCGGGGCCGCAGGAGGATGTAGATGAGTGTGCCCAAGGGCTAGATGACTGCCATGCCGACGCCCTGTGTCAGAACACACC
CACCTCCTACAAGTGCTCCTGCAAGCCTGGCTACCAAGGGGAAGGCAGGCAGTGTGAGGACATCGATGAATGTGGAAATGAGCTCAATGG
AGGCTGTGTCCATGACTGTTTGAATATTCCAGGCAATTATCGTTGCACTTGTTTTGATGGCTTCATGTTGGCTCATGACGGTCATAATTG
TCTTGATGTGGACGAGTGCCTGGAGAACAATGGCGGCTGCCAGCATACCTGTGTCAACGTCATGGGGAGCTATGAGTGCTGCTGCAAGGA
GGGGTTTTTCCTGAGTGACAATCAGCACACCTGCATTCACCGCTCGGAAGAGGGCCTGAGCTGCATGAATAAGGATCACGGCTGTAGTCA
CATCTGCAAGGAGGCCCCAAGGGGCAGCGTCGCCTGTGAGTGCAGGCCTGGTTTTGAGCTGGCCAAGAACCAGAGAGACTGCATCTTGAC
CTGTAACCATGGGAACGGTGGGTGCCAGCACTCCTGTGACGATACAGCCGATGGCCCAGAGTGCAGCTGCCATCCACAGTACAAGATGCA
CACAGATGGGAGGAGCTGCCTTGAGCGAGAGGACACTGTCCTGGAGGTGACAGAGAGCAACACCACATCAGTGGTGGATGGGGATAAACG
GGTGAAACGGCGGCTGCTCATGGAGAAAGCAATTGAGCTGCGTCTGGCAAAAATTGACCATACTGCAATTCACCCACATTTACTTGACAT
GAAGATTGGACAAGGGAAATATGAGCCGGGCTTCTTCCCTAAGCTGCAGTCTGATGTACTTTCCACTGGGCCAGCCAGCAACAAGTGGAC
GAAAAGGAATGCCCCTGCCCAGTGGAGGCGGAAAGATCGGCAGAAGCAGCACACAGAACACCTGCGTTTAGATAATGACCAGAGGGAGAA
GTACATCCAGGAAGCCAGGACTATGGGCAGCACTATCCGCCAGCCCAAACTGTCCAACCTCTCTCCATCAGTGATTGCCCAGACCAATTG
GAAGTTTGTAGAGGGCCTGCTGAAGGAATGCCGCAATAAGACCAAGAGGATGCTGGTGGAAAAGATGGGCCGAGAAGCTGTGGAGCTAGG
GCATGGGGAGGTGAACATCACAGGGGTGGAAGAGAACACCCTGATTGCCAGCCTTTGTGATCTCCTGGAAAGGATCTGGAGTCATGGACT
ACAAGTGAAACAGGGGAAATCAGCCTTATGGTCCCACCTGTTACATTATCAGGACAACCGGCAGAGAAAACTCACATCAGGAAGCCTCAG
TACCTCAGGAATACTTCTTGATTCAGAACGTAGGAAGTCTGATGCCAGCTCACTCATGCCTCCCCTGAGGATCTCCCTGATTCAGGATAT
GAGGCACATCCAGAACATCGGGGAAATCAAGACTGATGTGGGAAAGGCCAGAGCATGGGTGCGACTGTCCATGGAAAAAAAGTTACTTTC
CAGACACCTGAAGCAGCTCCTCTCAGACCATGAGCTCACCAAAAAGTTATATAAGCGCTATGCCTTCCTGCGCTGTGATGACGAGAAGGA
GCAGTTCCTCTATCACCTCCTGTCTTTCAATGCCGTCGATTACTTTTGCTTCACCAATGTCTTCACAACTATCCTGATCCCGTACCACAT
TCTGATCGTACCAAGCAAGAAGCTGGGGGGCTCCATGTTCACTGCCAACCCATGGATCTGTATATCAGGAGAATTGGGTGAGACACAGAT
CATGCAGATTCCCAGGAATGTGCTAGAGATGACCTTCGAGTGCCAGAACTTGGGGAAGCTTACTACTGTCCAGATTGGCCATGATAACTC
TGGGCTGTATGCCAAATGGCTGGTGGAGTATGTGATGGTCAGGAATGAGATCACAGGACATACCTACAAGTTCCCGTGTGGCCGGTGGTT
AGGGAAGGGCATGGATGATGGAAGCCTGGAGCGGATCCTAGTTGGGGAGCTGCTCACATCCCAGCCTGAGGTGGATGAGAGGCCATGCCG
GACCCCGCCGCTGCAGCAGTCCCCCAGTGTCATCCGGAGGCTTGTTACCATCTCACCCAACAACAAGCCCAAGCTGAACACTGGGCAGAT
CCAGGAGTCCATCGGGGAGGCAGTCAATGGCATTGTGAAGCACTTCCATAAGCCTGAGAAAGAGCGAGGCAGTCTGACGCTGTTGCTCTG
TGGAGAGTGTGGCCTTGTCTCGGCCTTGGAACAGGCTTTCCAGCATGGATTTAAATCGCCCCGGCTCTTCAAAAATGTCTTCATTTGGGA
TTTCCTGGAAAAAGCACAAACCTATTATGAGACATTAGAGAAGAATGAAGTAGTCCCTGAGGAAAACTGGCATACAAGAGCCCGGAACTT
CTGCCGATTTGTCACTGCAATCAACAATACTCCCCGGAACATCGGCAAGGATGAGATCACCTCCTACACCACTGGATTGCCCTGCTGGCT
GACTGCCCCATCACTGCACACATGTATGAGGATGTGGCACTGATCAAAGACCATACACTTGTCAATTCCTTGATTCGTGTGCTGCAGACA
TTGCAGGAGTTCAACATCACGCTGGAGACGTCCCTTGTCAAGGGCATCGACATCTGACCTCCCAGCACCAGCCAGCAGCAGGACTGAGAA
AGACTCACCCTGCAGCTCTGACCTTTTTTCCCAAAGGGACTTAAGCGATTGTGCAGGAGTAGGAGACAAAATGTACACTCACTGTAAAAA

>79753_79753_2_SCUBE2-DENND5A_SCUBE2_chr11_9087438_ENST00000309263_DENND5A_chr11_9192324_ENST00000530044_length(amino acids)=897AA_BP=291
MPATAEPSMGVAGRNRPGAAWAVLLLLLLLPPLLLLAGAVPPGRGRAAGPQEDVDECAQGLDDCHADALCQNTPTSYKCSCKPGYQGEGR
QCEDIDECGNELNGGCVHDCLNIPGNYRCTCFDGFMLAHDGHNCLDVDECLENNGGCQHTCVNVMGSYECCCKEGFFLSDNQHTCIHRSE
EGLSCMNKDHGCSHICKEAPRGSVACECRPGFELAKNQRDCILTCNHGNGGCQHSCDDTADGPECSCHPQYKMHTDGRSCLEREDTVLEV
TESNTTSVVDGDKRVKRRLLMEKAIELRLAKIDHTAIHPHLLDMKIGQGKYEPGFFPKLQSDVLSTGPASNKWTKRNAPAQWRRKDRQKQ
HTEHLRLDNDQREKYIQEARTMGSTIRQPKLSNLSPSVIAQTNWKFVEGLLKECRNKTKRMLVEKMGREAVELGHGEVNITGVEENTLIA
SLCDLLERIWSHGLQVKQGKSALWSHLLHYQDNRQRKLTSGSLSTSGILLDSERRKSDASSLMPPLRISLIQDMRHIQNIGEIKTDVGKA
RAWVRLSMEKKLLSRHLKQLLSDHELTKKLYKRYAFLRCDDEKEQFLYHLLSFNAVDYFCFTNVFTTILIPYHILIVPSKKLGGSMFTAN
PWICISGELGETQIMQIPRNVLEMTFECQNLGKLTTVQIGHDNSGLYAKWLVEYVMVRNEITGHTYKFPCGRWLGKGMDDGSLERILVGE
LLTSQPEVDERPCRTPPLQQSPSVIRRLVTISPNNKPKLNTGQIQESIGEAVNGIVKHFHKPEKERGSLTLLLCGECGLVSALEQAFQHG

--------------------------------------------------------------
>79753_79753_3_SCUBE2-DENND5A_SCUBE2_chr11_9087438_ENST00000450649_DENND5A_chr11_9192324_ENST00000328194_length(transcript)=3672nt_BP=868nt
GCAACCGCTGAGCCATCCATGGGGGTCGCGGGCCGCAACCGTCCCGGGGCGGCCTGGGCGGTGCTGCTGCTGCTGCTGCTGCTGCCGCCA
CTGCTGCTGCTGGCGGGGGCCGTCCCGCCGGGTCGGGGCCGTGCCGCGGGGCCGCAGGAGGATGTAGATGAGTGTGCCCAAGGGCTAGAT
GACTGCCATGCCGACGCCCTGTGTCAGAACACACCCACCTCCTACAAGTGCTCCTGCAAGCCTGGCTACCAAGGGGAAGGCAGGCAGTGT
GAGGACATCGATGAATGTGGAAATGAGCTCAATGGAGGCTGTGTCCATGACTGTTTGAATATTCCAGGCAATTATCGTTGCACTTGTTTT
GATGGCTTCATGTTGGCTCATGACGGTCATAATTGTCTTGATGTGGACGAGTGCCTGGAGAACAATGGCGGCTGCCAGCATACCTGTGTC
AACGTCATGGGGAGCTATGAGTGCTGCTGCAAGGAGGGGTTTTTCCTGAGTGACAATCAGCACACCTGCATTCACCGCTCGGAAGAGGGC
CTGAGCTGCATGAATAAGGATCACGGCTGTAGTCACATCTGCAAGGAGGCCCCAAGGGGCAGCGTCGCCTGTGAGTGCAGGCCTGGTTTT
GAGCTGGCCAAGAACCAGAGAGACTGCATCTTGACCTGTAACCATGGGAACGGTGGGTGCCAGCACTCCTGTGACGATACAGCCGATGGC
CCAGAGTGCAGCTGCCATCCACAGTACAAGATGCACACAGATGGGAGGAGCTGCCTTGAGCGAGAGGACACTGTCCTGGAGGTGACAGAG
AGCAACACCACATCAGTGGTGGATGGGGATAAACGGGTGAAACGGCGGCTGCTCATGGAGAAAGCAATTGAGCTGCGTCTGGCAAAAATT
GACCATACTGCAATTCACCCACATTTACTTGACATGAAGATTGGACAAGGGAAATATGAGCCGGGCTTCTTCCCTAAGCTGCAGTCTGAT
GTACTTTCCACTGGGCCAGCCAGCAACAAGTGGACGAAAAGGAATGCCCCTGCCCAGTGGAGGCGGAAAGATCGGCAGAAGCAGCACACA
GAACACCTGCGTTTAGATAATGACCAGAGGGAGAAGTACATCCAGGAAGCCAGGACTATGGGCAGCACTATCCGCCAGCCCAAACTGTCC
AACCTCTCTCCATCAGTGATTGCCCAGACCAATTGGAAGTTTGTAGAGGGCCTGCTGAAGGAATGCCGCAATAAGACCAAGAGGATGCTG
GTGGAAAAGATGGGCCGAGAAGCTGTGGAGCTAGGGCATGGGGAGGTGAACATCACAGGGGTGGAAGAGAACACCCTGATTGCCAGCCTT
TGTGATCTCCTGGAAAGGATCTGGAGTCATGGACTACAAGTGAAACAGGGGAAATCAGCCTTATGGTCCCACCTGTTACATTATCAGGAC
AACCGGCAGAGAAAACTCACATCAGGAAGCCTCAGTACCTCAGGAATACTTCTTGATTCAGAACGTAGGAAGTCTGATGCCAGCTCACTC
ATGCCTCCCCTGAGGATCTCCCTGATTCAGGATATGAGGCACATCCAGAACATCGGGGAAATCAAGACTGATGTGGGAAAGGCCAGAGCA
TGGGTGCGACTGTCCATGGAAAAAAAGTTACTTTCCAGACACCTGAAGCAGCTCCTCTCAGACCATGAGCTCACCAAAAAGTTATATAAG
CGCTATGCCTTCCTGCGCTGTGATGACGAGAAGGAGCAGTTCCTCTATCACCTCCTGTCTTTCAATGCCGTCGATTACTTTTGCTTCACC
AATGTCTTCACAACTATCCTGATCCCGTACCACATTCTGATCGTACCAAGCAAGAAGCTGGGGGGCTCCATGTTCACTGCCAACCCATGG
ATCTGTATATCAGGAGAATTGGGTGAGACACAGATCATGCAGATTCCCAGGAATGTGCTAGAGATGACCTTCGAGTGCCAGAACTTGGGG
AAGCTTACTACTGTCCAGATTGGCCATGATAACTCTGGGCTGTATGCCAAATGGCTGGTGGAGTATGTGATGGTCAGGAATGAGATCACA
GGACATACCTACAAGTTCCCGTGTGGCCGGTGGTTAGGGAAGGGCATGGATGATGGAAGCCTGGAGCGGATCCTAGTTGGGGAGCTGCTC
ACATCCCAGCCTGAGGTGGATGAGAGGCCATGCCGGACCCCGCCGCTGCAGCAGTCCCCCAGTGTCATCCGGAGGCTTGTTACCATCTCA
CCCAACAACAAGCCCAAGCTGAACACTGGGCAGATCCAGGAGTCCATCGGGGAGGCAGTCAATGGCATTGTGAAGCACTTCCATAAGCCT
GAGAAAGAGCGAGGCAGTCTGACGCTGTTGCTCTGTGGAGAGTGTGGCCTTGTCTCGGCCTTGGAACAGGCTTTCCAGCATGGATTTAAA
TCGCCCCGGCTCTTCAAAAATGTCTTCATTTGGGATTTCCTGGAAAAAGCACAAACCTATTATGAGACATTAGAGAAGAATGAAGTAGTC
CCTGAGGAAAACTGGCATACAAGAGCCCGGAACTTCTGCCGATTTGTCACTGCAATCAACAATACTCCCCGGAACATCGGCAAGGATGGC
AAGTTTCAGATGCTGGTGTGCTTGGGAGCCAGAGATCACCTCCTACACCACTGGATTGCCCTGCTGGCTGACTGCCCCATCACTGCACAC
ATGTATGAGGATGTGGCACTGATCAAAGACCATACACTTGTCAATTCCTTGATTCGTGTGCTGCAGACATTGCAGGAGTTCAACATCACG
CTGGAGACGTCCCTTGTCAAGGGCATCGACATCTGACCTCCCAGCACCAGCCAGCAGCAGGACTGAGAAAGACTCACCCTGCAGCTCTGA
CCTTTTTTCCCAAAGGGACTTAAGCGATTGTGCAGGAGTAGGAGACAAAATGTACACTCACTGTAAAAAGAAAACTAGAGGATTTTTGGA
ATAAATAATCTATTTTAGAGTTTATTTGCTGATTTGCTTTTTACACACTTTCATGTGAAAGAGTGATAGGGAGAGGGAGCGAGGCTGGTG
CCGCTTATTTTGAAGCTGGTGCCCTCCCTCGCCGTGGCCACATGCTGGAAGCCTGAGGCCTCCCTGGACTGAGCCTGTGGCACTGCGTGC
GGGACAGTTATGTTTCCTTGCCCCGTCGCATTAATGAGGCCCTTCCACATCATTTTTAAACTAATGTTTTTCTATATTAACATTATTATG
GATATTTGGCTTTCATAGGCCACACACAGGTGTGCTGCGCGGGAAGCCCCATGCTCCAATCAAAGGGATTTTTAGTAGTGCCTCTAAGCA
AGCACCGATGAGTCAGTCCCACGTATTTTCTTTTTTGTCAGTATTGTTTGGGAAGGAGACATGCCGGGATGTGTCATCGTGCCAAATACC
ACATTTCCTGTTGGCACAGTTTCACAGAAGTAAACATAAGCATGTTTTAACAGGTTTTTCTTTTCTTTTTTCTTTTTTAAAATGTTTTAT
TTATTTAACCCGCCATTGTGTGTTTTTAAGTATTTTCTTTTTTTAAGGAAAGGAAAAGCTTGTCACAATCTAACTGGCTATGTTATTATT

>79753_79753_3_SCUBE2-DENND5A_SCUBE2_chr11_9087438_ENST00000450649_DENND5A_chr11_9192324_ENST00000328194_length(amino acids)=935AA_BP=283
MGVAGRNRPGAAWAVLLLLLLLPPLLLLAGAVPPGRGRAAGPQEDVDECAQGLDDCHADALCQNTPTSYKCSCKPGYQGEGRQCEDIDEC
GNELNGGCVHDCLNIPGNYRCTCFDGFMLAHDGHNCLDVDECLENNGGCQHTCVNVMGSYECCCKEGFFLSDNQHTCIHRSEEGLSCMNK
DHGCSHICKEAPRGSVACECRPGFELAKNQRDCILTCNHGNGGCQHSCDDTADGPECSCHPQYKMHTDGRSCLEREDTVLEVTESNTTSV
VDGDKRVKRRLLMEKAIELRLAKIDHTAIHPHLLDMKIGQGKYEPGFFPKLQSDVLSTGPASNKWTKRNAPAQWRRKDRQKQHTEHLRLD
NDQREKYIQEARTMGSTIRQPKLSNLSPSVIAQTNWKFVEGLLKECRNKTKRMLVEKMGREAVELGHGEVNITGVEENTLIASLCDLLER
IWSHGLQVKQGKSALWSHLLHYQDNRQRKLTSGSLSTSGILLDSERRKSDASSLMPPLRISLIQDMRHIQNIGEIKTDVGKARAWVRLSM
EKKLLSRHLKQLLSDHELTKKLYKRYAFLRCDDEKEQFLYHLLSFNAVDYFCFTNVFTTILIPYHILIVPSKKLGGSMFTANPWICISGE
LGETQIMQIPRNVLEMTFECQNLGKLTTVQIGHDNSGLYAKWLVEYVMVRNEITGHTYKFPCGRWLGKGMDDGSLERILVGELLTSQPEV
DERPCRTPPLQQSPSVIRRLVTISPNNKPKLNTGQIQESIGEAVNGIVKHFHKPEKERGSLTLLLCGECGLVSALEQAFQHGFKSPRLFK
NVFIWDFLEKAQTYYETLEKNEVVPEENWHTRARNFCRFVTAINNTPRNIGKDGKFQMLVCLGARDHLLHHWIALLADCPITAHMYEDVA

--------------------------------------------------------------
>79753_79753_4_SCUBE2-DENND5A_SCUBE2_chr11_9087438_ENST00000450649_DENND5A_chr11_9192324_ENST00000530044_length(transcript)=3004nt_BP=868nt
GCAACCGCTGAGCCATCCATGGGGGTCGCGGGCCGCAACCGTCCCGGGGCGGCCTGGGCGGTGCTGCTGCTGCTGCTGCTGCTGCCGCCA
CTGCTGCTGCTGGCGGGGGCCGTCCCGCCGGGTCGGGGCCGTGCCGCGGGGCCGCAGGAGGATGTAGATGAGTGTGCCCAAGGGCTAGAT
GACTGCCATGCCGACGCCCTGTGTCAGAACACACCCACCTCCTACAAGTGCTCCTGCAAGCCTGGCTACCAAGGGGAAGGCAGGCAGTGT
GAGGACATCGATGAATGTGGAAATGAGCTCAATGGAGGCTGTGTCCATGACTGTTTGAATATTCCAGGCAATTATCGTTGCACTTGTTTT
GATGGCTTCATGTTGGCTCATGACGGTCATAATTGTCTTGATGTGGACGAGTGCCTGGAGAACAATGGCGGCTGCCAGCATACCTGTGTC
AACGTCATGGGGAGCTATGAGTGCTGCTGCAAGGAGGGGTTTTTCCTGAGTGACAATCAGCACACCTGCATTCACCGCTCGGAAGAGGGC
CTGAGCTGCATGAATAAGGATCACGGCTGTAGTCACATCTGCAAGGAGGCCCCAAGGGGCAGCGTCGCCTGTGAGTGCAGGCCTGGTTTT
GAGCTGGCCAAGAACCAGAGAGACTGCATCTTGACCTGTAACCATGGGAACGGTGGGTGCCAGCACTCCTGTGACGATACAGCCGATGGC
CCAGAGTGCAGCTGCCATCCACAGTACAAGATGCACACAGATGGGAGGAGCTGCCTTGAGCGAGAGGACACTGTCCTGGAGGTGACAGAG
AGCAACACCACATCAGTGGTGGATGGGGATAAACGGGTGAAACGGCGGCTGCTCATGGAGAAAGCAATTGAGCTGCGTCTGGCAAAAATT
GACCATACTGCAATTCACCCACATTTACTTGACATGAAGATTGGACAAGGGAAATATGAGCCGGGCTTCTTCCCTAAGCTGCAGTCTGAT
GTACTTTCCACTGGGCCAGCCAGCAACAAGTGGACGAAAAGGAATGCCCCTGCCCAGTGGAGGCGGAAAGATCGGCAGAAGCAGCACACA
GAACACCTGCGTTTAGATAATGACCAGAGGGAGAAGTACATCCAGGAAGCCAGGACTATGGGCAGCACTATCCGCCAGCCCAAACTGTCC
AACCTCTCTCCATCAGTGATTGCCCAGACCAATTGGAAGTTTGTAGAGGGCCTGCTGAAGGAATGCCGCAATAAGACCAAGAGGATGCTG
GTGGAAAAGATGGGCCGAGAAGCTGTGGAGCTAGGGCATGGGGAGGTGAACATCACAGGGGTGGAAGAGAACACCCTGATTGCCAGCCTT
TGTGATCTCCTGGAAAGGATCTGGAGTCATGGACTACAAGTGAAACAGGGGAAATCAGCCTTATGGTCCCACCTGTTACATTATCAGGAC
AACCGGCAGAGAAAACTCACATCAGGAAGCCTCAGTACCTCAGGAATACTTCTTGATTCAGAACGTAGGAAGTCTGATGCCAGCTCACTC
ATGCCTCCCCTGAGGATCTCCCTGATTCAGGATATGAGGCACATCCAGAACATCGGGGAAATCAAGACTGATGTGGGAAAGGCCAGAGCA
TGGGTGCGACTGTCCATGGAAAAAAAGTTACTTTCCAGACACCTGAAGCAGCTCCTCTCAGACCATGAGCTCACCAAAAAGTTATATAAG
CGCTATGCCTTCCTGCGCTGTGATGACGAGAAGGAGCAGTTCCTCTATCACCTCCTGTCTTTCAATGCCGTCGATTACTTTTGCTTCACC
AATGTCTTCACAACTATCCTGATCCCGTACCACATTCTGATCGTACCAAGCAAGAAGCTGGGGGGCTCCATGTTCACTGCCAACCCATGG
ATCTGTATATCAGGAGAATTGGGTGAGACACAGATCATGCAGATTCCCAGGAATGTGCTAGAGATGACCTTCGAGTGCCAGAACTTGGGG
AAGCTTACTACTGTCCAGATTGGCCATGATAACTCTGGGCTGTATGCCAAATGGCTGGTGGAGTATGTGATGGTCAGGAATGAGATCACA
GGACATACCTACAAGTTCCCGTGTGGCCGGTGGTTAGGGAAGGGCATGGATGATGGAAGCCTGGAGCGGATCCTAGTTGGGGAGCTGCTC
ACATCCCAGCCTGAGGTGGATGAGAGGCCATGCCGGACCCCGCCGCTGCAGCAGTCCCCCAGTGTCATCCGGAGGCTTGTTACCATCTCA
CCCAACAACAAGCCCAAGCTGAACACTGGGCAGATCCAGGAGTCCATCGGGGAGGCAGTCAATGGCATTGTGAAGCACTTCCATAAGCCT
GAGAAAGAGCGAGGCAGTCTGACGCTGTTGCTCTGTGGAGAGTGTGGCCTTGTCTCGGCCTTGGAACAGGCTTTCCAGCATGGATTTAAA
TCGCCCCGGCTCTTCAAAAATGTCTTCATTTGGGATTTCCTGGAAAAAGCACAAACCTATTATGAGACATTAGAGAAGAATGAAGTAGTC
CCTGAGGAAAACTGGCATACAAGAGCCCGGAACTTCTGCCGATTTGTCACTGCAATCAACAATACTCCCCGGAACATCGGCAAGGATGAG
ATCACCTCCTACACCACTGGATTGCCCTGCTGGCTGACTGCCCCATCACTGCACACATGTATGAGGATGTGGCACTGATCAAAGACCATA
CACTTGTCAATTCCTTGATTCGTGTGCTGCAGACATTGCAGGAGTTCAACATCACGCTGGAGACGTCCCTTGTCAAGGGCATCGACATCT
GACCTCCCAGCACCAGCCAGCAGCAGGACTGAGAAAGACTCACCCTGCAGCTCTGACCTTTTTTCCCAAAGGGACTTAAGCGATTGTGCA
GGAGTAGGAGACAAAATGTACACTCACTGTAAAAAGAAAACTAGAGGATTTTTGGAATAAATAATCTATTTTAGAGTTTATTTGCTGATT

>79753_79753_4_SCUBE2-DENND5A_SCUBE2_chr11_9087438_ENST00000450649_DENND5A_chr11_9192324_ENST00000530044_length(amino acids)=889AA_BP=283
MGVAGRNRPGAAWAVLLLLLLLPPLLLLAGAVPPGRGRAAGPQEDVDECAQGLDDCHADALCQNTPTSYKCSCKPGYQGEGRQCEDIDEC
GNELNGGCVHDCLNIPGNYRCTCFDGFMLAHDGHNCLDVDECLENNGGCQHTCVNVMGSYECCCKEGFFLSDNQHTCIHRSEEGLSCMNK
DHGCSHICKEAPRGSVACECRPGFELAKNQRDCILTCNHGNGGCQHSCDDTADGPECSCHPQYKMHTDGRSCLEREDTVLEVTESNTTSV
VDGDKRVKRRLLMEKAIELRLAKIDHTAIHPHLLDMKIGQGKYEPGFFPKLQSDVLSTGPASNKWTKRNAPAQWRRKDRQKQHTEHLRLD
NDQREKYIQEARTMGSTIRQPKLSNLSPSVIAQTNWKFVEGLLKECRNKTKRMLVEKMGREAVELGHGEVNITGVEENTLIASLCDLLER
IWSHGLQVKQGKSALWSHLLHYQDNRQRKLTSGSLSTSGILLDSERRKSDASSLMPPLRISLIQDMRHIQNIGEIKTDVGKARAWVRLSM
EKKLLSRHLKQLLSDHELTKKLYKRYAFLRCDDEKEQFLYHLLSFNAVDYFCFTNVFTTILIPYHILIVPSKKLGGSMFTANPWICISGE
LGETQIMQIPRNVLEMTFECQNLGKLTTVQIGHDNSGLYAKWLVEYVMVRNEITGHTYKFPCGRWLGKGMDDGSLERILVGELLTSQPEV
DERPCRTPPLQQSPSVIRRLVTISPNNKPKLNTGQIQESIGEAVNGIVKHFHKPEKERGSLTLLLCGECGLVSALEQAFQHGFKSPRLFK

--------------------------------------------------------------
>79753_79753_5_SCUBE2-DENND5A_SCUBE2_chr11_9087438_ENST00000457346_DENND5A_chr11_9192324_ENST00000328194_length(transcript)=3729nt_BP=925nt
CCGCGCACACCTCCCCGCGCCGCCGCCGCCACCGCCCGCACTCCGCCGCCTCTGCCCGCAACCGCTGAGCCATCCATGGGGGTCGCGGGC
CGCAACCGTCCCGGGGCGGCCTGGGCGGTGCTGCTGCTGCTGCTGCTGCTGCCGCCACTGCTGCTGCTGGCGGGGGCCGTCCCGCCGGGT
CGGGGCCGTGCCGCGGGGCCGCAGGAGGATGTAGATGAGTGTGCCCAAGGGCTAGATGACTGCCATGCCGACGCCCTGTGTCAGAACACA
CCCACCTCCTACAAGTGCTCCTGCAAGCCTGGCTACCAAGGGGAAGGCAGGCAGTGTGAGGACATCGATGAATGTGGAAATGAGCTCAAT
GGAGGCTGTGTCCATGACTGTTTGAATATTCCAGGCAATTATCGTTGCACTTGTTTTGATGGCTTCATGTTGGCTCATGACGGTCATAAT
TGTCTTGATGTGGACGAGTGCCTGGAGAACAATGGCGGCTGCCAGCATACCTGTGTCAACGTCATGGGGAGCTATGAGTGCTGCTGCAAG
GAGGGGTTTTTCCTGAGTGACAATCAGCACACCTGCATTCACCGCTCGGAAGAGGGCCTGAGCTGCATGAATAAGGATCACGGCTGTAGT
CACATCTGCAAGGAGGCCCCAAGGGGCAGCGTCGCCTGTGAGTGCAGGCCTGGTTTTGAGCTGGCCAAGAACCAGAGAGACTGCATCTTG
ACCTGTAACCATGGGAACGGTGGGTGCCAGCACTCCTGTGACGATACAGCCGATGGCCCAGAGTGCAGCTGCCATCCACAGTACAAGATG
CACACAGATGGGAGGAGCTGCCTTGAGCGAGAGGACACTGTCCTGGAGGTGACAGAGAGCAACACCACATCAGTGGTGGATGGGGATAAA
CGGGTGAAACGGCGGCTGCTCATGGAGAAAGCAATTGAGCTGCGTCTGGCAAAAATTGACCATACTGCAATTCACCCACATTTACTTGAC
ATGAAGATTGGACAAGGGAAATATGAGCCGGGCTTCTTCCCTAAGCTGCAGTCTGATGTACTTTCCACTGGGCCAGCCAGCAACAAGTGG
ACGAAAAGGAATGCCCCTGCCCAGTGGAGGCGGAAAGATCGGCAGAAGCAGCACACAGAACACCTGCGTTTAGATAATGACCAGAGGGAG
AAGTACATCCAGGAAGCCAGGACTATGGGCAGCACTATCCGCCAGCCCAAACTGTCCAACCTCTCTCCATCAGTGATTGCCCAGACCAAT
TGGAAGTTTGTAGAGGGCCTGCTGAAGGAATGCCGCAATAAGACCAAGAGGATGCTGGTGGAAAAGATGGGCCGAGAAGCTGTGGAGCTA
GGGCATGGGGAGGTGAACATCACAGGGGTGGAAGAGAACACCCTGATTGCCAGCCTTTGTGATCTCCTGGAAAGGATCTGGAGTCATGGA
CTACAAGTGAAACAGGGGAAATCAGCCTTATGGTCCCACCTGTTACATTATCAGGACAACCGGCAGAGAAAACTCACATCAGGAAGCCTC
AGTACCTCAGGAATACTTCTTGATTCAGAACGTAGGAAGTCTGATGCCAGCTCACTCATGCCTCCCCTGAGGATCTCCCTGATTCAGGAT
ATGAGGCACATCCAGAACATCGGGGAAATCAAGACTGATGTGGGAAAGGCCAGAGCATGGGTGCGACTGTCCATGGAAAAAAAGTTACTT
TCCAGACACCTGAAGCAGCTCCTCTCAGACCATGAGCTCACCAAAAAGTTATATAAGCGCTATGCCTTCCTGCGCTGTGATGACGAGAAG
GAGCAGTTCCTCTATCACCTCCTGTCTTTCAATGCCGTCGATTACTTTTGCTTCACCAATGTCTTCACAACTATCCTGATCCCGTACCAC
ATTCTGATCGTACCAAGCAAGAAGCTGGGGGGCTCCATGTTCACTGCCAACCCATGGATCTGTATATCAGGAGAATTGGGTGAGACACAG
ATCATGCAGATTCCCAGGAATGTGCTAGAGATGACCTTCGAGTGCCAGAACTTGGGGAAGCTTACTACTGTCCAGATTGGCCATGATAAC
TCTGGGCTGTATGCCAAATGGCTGGTGGAGTATGTGATGGTCAGGAATGAGATCACAGGACATACCTACAAGTTCCCGTGTGGCCGGTGG
TTAGGGAAGGGCATGGATGATGGAAGCCTGGAGCGGATCCTAGTTGGGGAGCTGCTCACATCCCAGCCTGAGGTGGATGAGAGGCCATGC
CGGACCCCGCCGCTGCAGCAGTCCCCCAGTGTCATCCGGAGGCTTGTTACCATCTCACCCAACAACAAGCCCAAGCTGAACACTGGGCAG
ATCCAGGAGTCCATCGGGGAGGCAGTCAATGGCATTGTGAAGCACTTCCATAAGCCTGAGAAAGAGCGAGGCAGTCTGACGCTGTTGCTC
TGTGGAGAGTGTGGCCTTGTCTCGGCCTTGGAACAGGCTTTCCAGCATGGATTTAAATCGCCCCGGCTCTTCAAAAATGTCTTCATTTGG
GATTTCCTGGAAAAAGCACAAACCTATTATGAGACATTAGAGAAGAATGAAGTAGTCCCTGAGGAAAACTGGCATACAAGAGCCCGGAAC
TTCTGCCGATTTGTCACTGCAATCAACAATACTCCCCGGAACATCGGCAAGGATGGCAAGTTTCAGATGCTGGTGTGCTTGGGAGCCAGA
GATCACCTCCTACACCACTGGATTGCCCTGCTGGCTGACTGCCCCATCACTGCACACATGTATGAGGATGTGGCACTGATCAAAGACCAT
ACACTTGTCAATTCCTTGATTCGTGTGCTGCAGACATTGCAGGAGTTCAACATCACGCTGGAGACGTCCCTTGTCAAGGGCATCGACATC
TGACCTCCCAGCACCAGCCAGCAGCAGGACTGAGAAAGACTCACCCTGCAGCTCTGACCTTTTTTCCCAAAGGGACTTAAGCGATTGTGC
AGGAGTAGGAGACAAAATGTACACTCACTGTAAAAAGAAAACTAGAGGATTTTTGGAATAAATAATCTATTTTAGAGTTTATTTGCTGAT
TTGCTTTTTACACACTTTCATGTGAAAGAGTGATAGGGAGAGGGAGCGAGGCTGGTGCCGCTTATTTTGAAGCTGGTGCCCTCCCTCGCC
GTGGCCACATGCTGGAAGCCTGAGGCCTCCCTGGACTGAGCCTGTGGCACTGCGTGCGGGACAGTTATGTTTCCTTGCCCCGTCGCATTA
ATGAGGCCCTTCCACATCATTTTTAAACTAATGTTTTTCTATATTAACATTATTATGGATATTTGGCTTTCATAGGCCACACACAGGTGT
GCTGCGCGGGAAGCCCCATGCTCCAATCAAAGGGATTTTTAGTAGTGCCTCTAAGCAAGCACCGATGAGTCAGTCCCACGTATTTTCTTT
TTTGTCAGTATTGTTTGGGAAGGAGACATGCCGGGATGTGTCATCGTGCCAAATACCACATTTCCTGTTGGCACAGTTTCACAGAAGTAA
ACATAAGCATGTTTTAACAGGTTTTTCTTTTCTTTTTTCTTTTTTAAAATGTTTTATTTATTTAACCCGCCATTGTGTGTTTTTAAGTAT
TTTCTTTTTTTAAGGAAAGGAAAAGCTTGTCACAATCTAACTGGCTATGTTATTATTATTAAATTTATGTTTTGCAACTTAGAAACCAGC

>79753_79753_5_SCUBE2-DENND5A_SCUBE2_chr11_9087438_ENST00000457346_DENND5A_chr11_9192324_ENST00000328194_length(amino acids)=943AA_BP=291
MPATAEPSMGVAGRNRPGAAWAVLLLLLLLPPLLLLAGAVPPGRGRAAGPQEDVDECAQGLDDCHADALCQNTPTSYKCSCKPGYQGEGR
QCEDIDECGNELNGGCVHDCLNIPGNYRCTCFDGFMLAHDGHNCLDVDECLENNGGCQHTCVNVMGSYECCCKEGFFLSDNQHTCIHRSE
EGLSCMNKDHGCSHICKEAPRGSVACECRPGFELAKNQRDCILTCNHGNGGCQHSCDDTADGPECSCHPQYKMHTDGRSCLEREDTVLEV
TESNTTSVVDGDKRVKRRLLMEKAIELRLAKIDHTAIHPHLLDMKIGQGKYEPGFFPKLQSDVLSTGPASNKWTKRNAPAQWRRKDRQKQ
HTEHLRLDNDQREKYIQEARTMGSTIRQPKLSNLSPSVIAQTNWKFVEGLLKECRNKTKRMLVEKMGREAVELGHGEVNITGVEENTLIA
SLCDLLERIWSHGLQVKQGKSALWSHLLHYQDNRQRKLTSGSLSTSGILLDSERRKSDASSLMPPLRISLIQDMRHIQNIGEIKTDVGKA
RAWVRLSMEKKLLSRHLKQLLSDHELTKKLYKRYAFLRCDDEKEQFLYHLLSFNAVDYFCFTNVFTTILIPYHILIVPSKKLGGSMFTAN
PWICISGELGETQIMQIPRNVLEMTFECQNLGKLTTVQIGHDNSGLYAKWLVEYVMVRNEITGHTYKFPCGRWLGKGMDDGSLERILVGE
LLTSQPEVDERPCRTPPLQQSPSVIRRLVTISPNNKPKLNTGQIQESIGEAVNGIVKHFHKPEKERGSLTLLLCGECGLVSALEQAFQHG
FKSPRLFKNVFIWDFLEKAQTYYETLEKNEVVPEENWHTRARNFCRFVTAINNTPRNIGKDGKFQMLVCLGARDHLLHHWIALLADCPIT

--------------------------------------------------------------
>79753_79753_6_SCUBE2-DENND5A_SCUBE2_chr11_9087438_ENST00000457346_DENND5A_chr11_9192324_ENST00000530044_length(transcript)=3061nt_BP=925nt
CCGCGCACACCTCCCCGCGCCGCCGCCGCCACCGCCCGCACTCCGCCGCCTCTGCCCGCAACCGCTGAGCCATCCATGGGGGTCGCGGGC
CGCAACCGTCCCGGGGCGGCCTGGGCGGTGCTGCTGCTGCTGCTGCTGCTGCCGCCACTGCTGCTGCTGGCGGGGGCCGTCCCGCCGGGT
CGGGGCCGTGCCGCGGGGCCGCAGGAGGATGTAGATGAGTGTGCCCAAGGGCTAGATGACTGCCATGCCGACGCCCTGTGTCAGAACACA
CCCACCTCCTACAAGTGCTCCTGCAAGCCTGGCTACCAAGGGGAAGGCAGGCAGTGTGAGGACATCGATGAATGTGGAAATGAGCTCAAT
GGAGGCTGTGTCCATGACTGTTTGAATATTCCAGGCAATTATCGTTGCACTTGTTTTGATGGCTTCATGTTGGCTCATGACGGTCATAAT
TGTCTTGATGTGGACGAGTGCCTGGAGAACAATGGCGGCTGCCAGCATACCTGTGTCAACGTCATGGGGAGCTATGAGTGCTGCTGCAAG
GAGGGGTTTTTCCTGAGTGACAATCAGCACACCTGCATTCACCGCTCGGAAGAGGGCCTGAGCTGCATGAATAAGGATCACGGCTGTAGT
CACATCTGCAAGGAGGCCCCAAGGGGCAGCGTCGCCTGTGAGTGCAGGCCTGGTTTTGAGCTGGCCAAGAACCAGAGAGACTGCATCTTG
ACCTGTAACCATGGGAACGGTGGGTGCCAGCACTCCTGTGACGATACAGCCGATGGCCCAGAGTGCAGCTGCCATCCACAGTACAAGATG
CACACAGATGGGAGGAGCTGCCTTGAGCGAGAGGACACTGTCCTGGAGGTGACAGAGAGCAACACCACATCAGTGGTGGATGGGGATAAA
CGGGTGAAACGGCGGCTGCTCATGGAGAAAGCAATTGAGCTGCGTCTGGCAAAAATTGACCATACTGCAATTCACCCACATTTACTTGAC
ATGAAGATTGGACAAGGGAAATATGAGCCGGGCTTCTTCCCTAAGCTGCAGTCTGATGTACTTTCCACTGGGCCAGCCAGCAACAAGTGG
ACGAAAAGGAATGCCCCTGCCCAGTGGAGGCGGAAAGATCGGCAGAAGCAGCACACAGAACACCTGCGTTTAGATAATGACCAGAGGGAG
AAGTACATCCAGGAAGCCAGGACTATGGGCAGCACTATCCGCCAGCCCAAACTGTCCAACCTCTCTCCATCAGTGATTGCCCAGACCAAT
TGGAAGTTTGTAGAGGGCCTGCTGAAGGAATGCCGCAATAAGACCAAGAGGATGCTGGTGGAAAAGATGGGCCGAGAAGCTGTGGAGCTA
GGGCATGGGGAGGTGAACATCACAGGGGTGGAAGAGAACACCCTGATTGCCAGCCTTTGTGATCTCCTGGAAAGGATCTGGAGTCATGGA
CTACAAGTGAAACAGGGGAAATCAGCCTTATGGTCCCACCTGTTACATTATCAGGACAACCGGCAGAGAAAACTCACATCAGGAAGCCTC
AGTACCTCAGGAATACTTCTTGATTCAGAACGTAGGAAGTCTGATGCCAGCTCACTCATGCCTCCCCTGAGGATCTCCCTGATTCAGGAT
ATGAGGCACATCCAGAACATCGGGGAAATCAAGACTGATGTGGGAAAGGCCAGAGCATGGGTGCGACTGTCCATGGAAAAAAAGTTACTT
TCCAGACACCTGAAGCAGCTCCTCTCAGACCATGAGCTCACCAAAAAGTTATATAAGCGCTATGCCTTCCTGCGCTGTGATGACGAGAAG
GAGCAGTTCCTCTATCACCTCCTGTCTTTCAATGCCGTCGATTACTTTTGCTTCACCAATGTCTTCACAACTATCCTGATCCCGTACCAC
ATTCTGATCGTACCAAGCAAGAAGCTGGGGGGCTCCATGTTCACTGCCAACCCATGGATCTGTATATCAGGAGAATTGGGTGAGACACAG
ATCATGCAGATTCCCAGGAATGTGCTAGAGATGACCTTCGAGTGCCAGAACTTGGGGAAGCTTACTACTGTCCAGATTGGCCATGATAAC
TCTGGGCTGTATGCCAAATGGCTGGTGGAGTATGTGATGGTCAGGAATGAGATCACAGGACATACCTACAAGTTCCCGTGTGGCCGGTGG
TTAGGGAAGGGCATGGATGATGGAAGCCTGGAGCGGATCCTAGTTGGGGAGCTGCTCACATCCCAGCCTGAGGTGGATGAGAGGCCATGC
CGGACCCCGCCGCTGCAGCAGTCCCCCAGTGTCATCCGGAGGCTTGTTACCATCTCACCCAACAACAAGCCCAAGCTGAACACTGGGCAG
ATCCAGGAGTCCATCGGGGAGGCAGTCAATGGCATTGTGAAGCACTTCCATAAGCCTGAGAAAGAGCGAGGCAGTCTGACGCTGTTGCTC
TGTGGAGAGTGTGGCCTTGTCTCGGCCTTGGAACAGGCTTTCCAGCATGGATTTAAATCGCCCCGGCTCTTCAAAAATGTCTTCATTTGG
GATTTCCTGGAAAAAGCACAAACCTATTATGAGACATTAGAGAAGAATGAAGTAGTCCCTGAGGAAAACTGGCATACAAGAGCCCGGAAC
TTCTGCCGATTTGTCACTGCAATCAACAATACTCCCCGGAACATCGGCAAGGATGAGATCACCTCCTACACCACTGGATTGCCCTGCTGG
CTGACTGCCCCATCACTGCACACATGTATGAGGATGTGGCACTGATCAAAGACCATACACTTGTCAATTCCTTGATTCGTGTGCTGCAGA
CATTGCAGGAGTTCAACATCACGCTGGAGACGTCCCTTGTCAAGGGCATCGACATCTGACCTCCCAGCACCAGCCAGCAGCAGGACTGAG
AAAGACTCACCCTGCAGCTCTGACCTTTTTTCCCAAAGGGACTTAAGCGATTGTGCAGGAGTAGGAGACAAAATGTACACTCACTGTAAA
AAGAAAACTAGAGGATTTTTGGAATAAATAATCTATTTTAGAGTTTATTTGCTGATTTGCTTTTTACACACTTTCATGTGAAAGAGTGAT

>79753_79753_6_SCUBE2-DENND5A_SCUBE2_chr11_9087438_ENST00000457346_DENND5A_chr11_9192324_ENST00000530044_length(amino acids)=897AA_BP=291
MPATAEPSMGVAGRNRPGAAWAVLLLLLLLPPLLLLAGAVPPGRGRAAGPQEDVDECAQGLDDCHADALCQNTPTSYKCSCKPGYQGEGR
QCEDIDECGNELNGGCVHDCLNIPGNYRCTCFDGFMLAHDGHNCLDVDECLENNGGCQHTCVNVMGSYECCCKEGFFLSDNQHTCIHRSE
EGLSCMNKDHGCSHICKEAPRGSVACECRPGFELAKNQRDCILTCNHGNGGCQHSCDDTADGPECSCHPQYKMHTDGRSCLEREDTVLEV
TESNTTSVVDGDKRVKRRLLMEKAIELRLAKIDHTAIHPHLLDMKIGQGKYEPGFFPKLQSDVLSTGPASNKWTKRNAPAQWRRKDRQKQ
HTEHLRLDNDQREKYIQEARTMGSTIRQPKLSNLSPSVIAQTNWKFVEGLLKECRNKTKRMLVEKMGREAVELGHGEVNITGVEENTLIA
SLCDLLERIWSHGLQVKQGKSALWSHLLHYQDNRQRKLTSGSLSTSGILLDSERRKSDASSLMPPLRISLIQDMRHIQNIGEIKTDVGKA
RAWVRLSMEKKLLSRHLKQLLSDHELTKKLYKRYAFLRCDDEKEQFLYHLLSFNAVDYFCFTNVFTTILIPYHILIVPSKKLGGSMFTAN
PWICISGELGETQIMQIPRNVLEMTFECQNLGKLTTVQIGHDNSGLYAKWLVEYVMVRNEITGHTYKFPCGRWLGKGMDDGSLERILVGE
LLTSQPEVDERPCRTPPLQQSPSVIRRLVTISPNNKPKLNTGQIQESIGEAVNGIVKHFHKPEKERGSLTLLLCGECGLVSALEQAFQHG

--------------------------------------------------------------
>79753_79753_7_SCUBE2-DENND5A_SCUBE2_chr11_9087438_ENST00000520467_DENND5A_chr11_9192324_ENST00000328194_length(transcript)=3725nt_BP=921nt
GCACACCTCCCCGCGCCGCCGCCGCCACCGCCCGCACTCCGCCGCCTCTGCCCGCAACCGCTGAGCCATCCATGGGGGTCGCGGGCCGCA
ACCGTCCCGGGGCGGCCTGGGCGGTGCTGCTGCTGCTGCTGCTGCTGCCGCCACTGCTGCTGCTGGCGGGGGCCGTCCCGCCGGGTCGGG
GCCGTGCCGCGGGGCCGCAGGAGGATGTAGATGAGTGTGCCCAAGGGCTAGATGACTGCCATGCCGACGCCCTGTGTCAGAACACACCCA
CCTCCTACAAGTGCTCCTGCAAGCCTGGCTACCAAGGGGAAGGCAGGCAGTGTGAGGACATCGATGAATGTGGAAATGAGCTCAATGGAG
GCTGTGTCCATGACTGTTTGAATATTCCAGGCAATTATCGTTGCACTTGTTTTGATGGCTTCATGTTGGCTCATGACGGTCATAATTGTC
TTGATGTGGACGAGTGCCTGGAGAACAATGGCGGCTGCCAGCATACCTGTGTCAACGTCATGGGGAGCTATGAGTGCTGCTGCAAGGAGG
GGTTTTTCCTGAGTGACAATCAGCACACCTGCATTCACCGCTCGGAAGAGGGCCTGAGCTGCATGAATAAGGATCACGGCTGTAGTCACA
TCTGCAAGGAGGCCCCAAGGGGCAGCGTCGCCTGTGAGTGCAGGCCTGGTTTTGAGCTGGCCAAGAACCAGAGAGACTGCATCTTGACCT
GTAACCATGGGAACGGTGGGTGCCAGCACTCCTGTGACGATACAGCCGATGGCCCAGAGTGCAGCTGCCATCCACAGTACAAGATGCACA
CAGATGGGAGGAGCTGCCTTGAGCGAGAGGACACTGTCCTGGAGGTGACAGAGAGCAACACCACATCAGTGGTGGATGGGGATAAACGGG
TGAAACGGCGGCTGCTCATGGAGAAAGCAATTGAGCTGCGTCTGGCAAAAATTGACCATACTGCAATTCACCCACATTTACTTGACATGA
AGATTGGACAAGGGAAATATGAGCCGGGCTTCTTCCCTAAGCTGCAGTCTGATGTACTTTCCACTGGGCCAGCCAGCAACAAGTGGACGA
AAAGGAATGCCCCTGCCCAGTGGAGGCGGAAAGATCGGCAGAAGCAGCACACAGAACACCTGCGTTTAGATAATGACCAGAGGGAGAAGT
ACATCCAGGAAGCCAGGACTATGGGCAGCACTATCCGCCAGCCCAAACTGTCCAACCTCTCTCCATCAGTGATTGCCCAGACCAATTGGA
AGTTTGTAGAGGGCCTGCTGAAGGAATGCCGCAATAAGACCAAGAGGATGCTGGTGGAAAAGATGGGCCGAGAAGCTGTGGAGCTAGGGC
ATGGGGAGGTGAACATCACAGGGGTGGAAGAGAACACCCTGATTGCCAGCCTTTGTGATCTCCTGGAAAGGATCTGGAGTCATGGACTAC
AAGTGAAACAGGGGAAATCAGCCTTATGGTCCCACCTGTTACATTATCAGGACAACCGGCAGAGAAAACTCACATCAGGAAGCCTCAGTA
CCTCAGGAATACTTCTTGATTCAGAACGTAGGAAGTCTGATGCCAGCTCACTCATGCCTCCCCTGAGGATCTCCCTGATTCAGGATATGA
GGCACATCCAGAACATCGGGGAAATCAAGACTGATGTGGGAAAGGCCAGAGCATGGGTGCGACTGTCCATGGAAAAAAAGTTACTTTCCA
GACACCTGAAGCAGCTCCTCTCAGACCATGAGCTCACCAAAAAGTTATATAAGCGCTATGCCTTCCTGCGCTGTGATGACGAGAAGGAGC
AGTTCCTCTATCACCTCCTGTCTTTCAATGCCGTCGATTACTTTTGCTTCACCAATGTCTTCACAACTATCCTGATCCCGTACCACATTC
TGATCGTACCAAGCAAGAAGCTGGGGGGCTCCATGTTCACTGCCAACCCATGGATCTGTATATCAGGAGAATTGGGTGAGACACAGATCA
TGCAGATTCCCAGGAATGTGCTAGAGATGACCTTCGAGTGCCAGAACTTGGGGAAGCTTACTACTGTCCAGATTGGCCATGATAACTCTG
GGCTGTATGCCAAATGGCTGGTGGAGTATGTGATGGTCAGGAATGAGATCACAGGACATACCTACAAGTTCCCGTGTGGCCGGTGGTTAG
GGAAGGGCATGGATGATGGAAGCCTGGAGCGGATCCTAGTTGGGGAGCTGCTCACATCCCAGCCTGAGGTGGATGAGAGGCCATGCCGGA
CCCCGCCGCTGCAGCAGTCCCCCAGTGTCATCCGGAGGCTTGTTACCATCTCACCCAACAACAAGCCCAAGCTGAACACTGGGCAGATCC
AGGAGTCCATCGGGGAGGCAGTCAATGGCATTGTGAAGCACTTCCATAAGCCTGAGAAAGAGCGAGGCAGTCTGACGCTGTTGCTCTGTG
GAGAGTGTGGCCTTGTCTCGGCCTTGGAACAGGCTTTCCAGCATGGATTTAAATCGCCCCGGCTCTTCAAAAATGTCTTCATTTGGGATT
TCCTGGAAAAAGCACAAACCTATTATGAGACATTAGAGAAGAATGAAGTAGTCCCTGAGGAAAACTGGCATACAAGAGCCCGGAACTTCT
GCCGATTTGTCACTGCAATCAACAATACTCCCCGGAACATCGGCAAGGATGGCAAGTTTCAGATGCTGGTGTGCTTGGGAGCCAGAGATC
ACCTCCTACACCACTGGATTGCCCTGCTGGCTGACTGCCCCATCACTGCACACATGTATGAGGATGTGGCACTGATCAAAGACCATACAC
TTGTCAATTCCTTGATTCGTGTGCTGCAGACATTGCAGGAGTTCAACATCACGCTGGAGACGTCCCTTGTCAAGGGCATCGACATCTGAC
CTCCCAGCACCAGCCAGCAGCAGGACTGAGAAAGACTCACCCTGCAGCTCTGACCTTTTTTCCCAAAGGGACTTAAGCGATTGTGCAGGA
GTAGGAGACAAAATGTACACTCACTGTAAAAAGAAAACTAGAGGATTTTTGGAATAAATAATCTATTTTAGAGTTTATTTGCTGATTTGC
TTTTTACACACTTTCATGTGAAAGAGTGATAGGGAGAGGGAGCGAGGCTGGTGCCGCTTATTTTGAAGCTGGTGCCCTCCCTCGCCGTGG
CCACATGCTGGAAGCCTGAGGCCTCCCTGGACTGAGCCTGTGGCACTGCGTGCGGGACAGTTATGTTTCCTTGCCCCGTCGCATTAATGA
GGCCCTTCCACATCATTTTTAAACTAATGTTTTTCTATATTAACATTATTATGGATATTTGGCTTTCATAGGCCACACACAGGTGTGCTG
CGCGGGAAGCCCCATGCTCCAATCAAAGGGATTTTTAGTAGTGCCTCTAAGCAAGCACCGATGAGTCAGTCCCACGTATTTTCTTTTTTG
TCAGTATTGTTTGGGAAGGAGACATGCCGGGATGTGTCATCGTGCCAAATACCACATTTCCTGTTGGCACAGTTTCACAGAAGTAAACAT
AAGCATGTTTTAACAGGTTTTTCTTTTCTTTTTTCTTTTTTAAAATGTTTTATTTATTTAACCCGCCATTGTGTGTTTTTAAGTATTTTC
TTTTTTTAAGGAAAGGAAAAGCTTGTCACAATCTAACTGGCTATGTTATTATTATTAAATTTATGTTTTGCAACTTAGAAACCAGCTACA

>79753_79753_7_SCUBE2-DENND5A_SCUBE2_chr11_9087438_ENST00000520467_DENND5A_chr11_9192324_ENST00000328194_length(amino acids)=943AA_BP=291
MPATAEPSMGVAGRNRPGAAWAVLLLLLLLPPLLLLAGAVPPGRGRAAGPQEDVDECAQGLDDCHADALCQNTPTSYKCSCKPGYQGEGR
QCEDIDECGNELNGGCVHDCLNIPGNYRCTCFDGFMLAHDGHNCLDVDECLENNGGCQHTCVNVMGSYECCCKEGFFLSDNQHTCIHRSE
EGLSCMNKDHGCSHICKEAPRGSVACECRPGFELAKNQRDCILTCNHGNGGCQHSCDDTADGPECSCHPQYKMHTDGRSCLEREDTVLEV
TESNTTSVVDGDKRVKRRLLMEKAIELRLAKIDHTAIHPHLLDMKIGQGKYEPGFFPKLQSDVLSTGPASNKWTKRNAPAQWRRKDRQKQ
HTEHLRLDNDQREKYIQEARTMGSTIRQPKLSNLSPSVIAQTNWKFVEGLLKECRNKTKRMLVEKMGREAVELGHGEVNITGVEENTLIA
SLCDLLERIWSHGLQVKQGKSALWSHLLHYQDNRQRKLTSGSLSTSGILLDSERRKSDASSLMPPLRISLIQDMRHIQNIGEIKTDVGKA
RAWVRLSMEKKLLSRHLKQLLSDHELTKKLYKRYAFLRCDDEKEQFLYHLLSFNAVDYFCFTNVFTTILIPYHILIVPSKKLGGSMFTAN
PWICISGELGETQIMQIPRNVLEMTFECQNLGKLTTVQIGHDNSGLYAKWLVEYVMVRNEITGHTYKFPCGRWLGKGMDDGSLERILVGE
LLTSQPEVDERPCRTPPLQQSPSVIRRLVTISPNNKPKLNTGQIQESIGEAVNGIVKHFHKPEKERGSLTLLLCGECGLVSALEQAFQHG
FKSPRLFKNVFIWDFLEKAQTYYETLEKNEVVPEENWHTRARNFCRFVTAINNTPRNIGKDGKFQMLVCLGARDHLLHHWIALLADCPIT

--------------------------------------------------------------
>79753_79753_8_SCUBE2-DENND5A_SCUBE2_chr11_9087438_ENST00000520467_DENND5A_chr11_9192324_ENST00000530044_length(transcript)=3057nt_BP=921nt
GCACACCTCCCCGCGCCGCCGCCGCCACCGCCCGCACTCCGCCGCCTCTGCCCGCAACCGCTGAGCCATCCATGGGGGTCGCGGGCCGCA
ACCGTCCCGGGGCGGCCTGGGCGGTGCTGCTGCTGCTGCTGCTGCTGCCGCCACTGCTGCTGCTGGCGGGGGCCGTCCCGCCGGGTCGGG
GCCGTGCCGCGGGGCCGCAGGAGGATGTAGATGAGTGTGCCCAAGGGCTAGATGACTGCCATGCCGACGCCCTGTGTCAGAACACACCCA
CCTCCTACAAGTGCTCCTGCAAGCCTGGCTACCAAGGGGAAGGCAGGCAGTGTGAGGACATCGATGAATGTGGAAATGAGCTCAATGGAG
GCTGTGTCCATGACTGTTTGAATATTCCAGGCAATTATCGTTGCACTTGTTTTGATGGCTTCATGTTGGCTCATGACGGTCATAATTGTC
TTGATGTGGACGAGTGCCTGGAGAACAATGGCGGCTGCCAGCATACCTGTGTCAACGTCATGGGGAGCTATGAGTGCTGCTGCAAGGAGG
GGTTTTTCCTGAGTGACAATCAGCACACCTGCATTCACCGCTCGGAAGAGGGCCTGAGCTGCATGAATAAGGATCACGGCTGTAGTCACA
TCTGCAAGGAGGCCCCAAGGGGCAGCGTCGCCTGTGAGTGCAGGCCTGGTTTTGAGCTGGCCAAGAACCAGAGAGACTGCATCTTGACCT
GTAACCATGGGAACGGTGGGTGCCAGCACTCCTGTGACGATACAGCCGATGGCCCAGAGTGCAGCTGCCATCCACAGTACAAGATGCACA
CAGATGGGAGGAGCTGCCTTGAGCGAGAGGACACTGTCCTGGAGGTGACAGAGAGCAACACCACATCAGTGGTGGATGGGGATAAACGGG
TGAAACGGCGGCTGCTCATGGAGAAAGCAATTGAGCTGCGTCTGGCAAAAATTGACCATACTGCAATTCACCCACATTTACTTGACATGA
AGATTGGACAAGGGAAATATGAGCCGGGCTTCTTCCCTAAGCTGCAGTCTGATGTACTTTCCACTGGGCCAGCCAGCAACAAGTGGACGA
AAAGGAATGCCCCTGCCCAGTGGAGGCGGAAAGATCGGCAGAAGCAGCACACAGAACACCTGCGTTTAGATAATGACCAGAGGGAGAAGT
ACATCCAGGAAGCCAGGACTATGGGCAGCACTATCCGCCAGCCCAAACTGTCCAACCTCTCTCCATCAGTGATTGCCCAGACCAATTGGA
AGTTTGTAGAGGGCCTGCTGAAGGAATGCCGCAATAAGACCAAGAGGATGCTGGTGGAAAAGATGGGCCGAGAAGCTGTGGAGCTAGGGC
ATGGGGAGGTGAACATCACAGGGGTGGAAGAGAACACCCTGATTGCCAGCCTTTGTGATCTCCTGGAAAGGATCTGGAGTCATGGACTAC
AAGTGAAACAGGGGAAATCAGCCTTATGGTCCCACCTGTTACATTATCAGGACAACCGGCAGAGAAAACTCACATCAGGAAGCCTCAGTA
CCTCAGGAATACTTCTTGATTCAGAACGTAGGAAGTCTGATGCCAGCTCACTCATGCCTCCCCTGAGGATCTCCCTGATTCAGGATATGA
GGCACATCCAGAACATCGGGGAAATCAAGACTGATGTGGGAAAGGCCAGAGCATGGGTGCGACTGTCCATGGAAAAAAAGTTACTTTCCA
GACACCTGAAGCAGCTCCTCTCAGACCATGAGCTCACCAAAAAGTTATATAAGCGCTATGCCTTCCTGCGCTGTGATGACGAGAAGGAGC
AGTTCCTCTATCACCTCCTGTCTTTCAATGCCGTCGATTACTTTTGCTTCACCAATGTCTTCACAACTATCCTGATCCCGTACCACATTC
TGATCGTACCAAGCAAGAAGCTGGGGGGCTCCATGTTCACTGCCAACCCATGGATCTGTATATCAGGAGAATTGGGTGAGACACAGATCA
TGCAGATTCCCAGGAATGTGCTAGAGATGACCTTCGAGTGCCAGAACTTGGGGAAGCTTACTACTGTCCAGATTGGCCATGATAACTCTG
GGCTGTATGCCAAATGGCTGGTGGAGTATGTGATGGTCAGGAATGAGATCACAGGACATACCTACAAGTTCCCGTGTGGCCGGTGGTTAG
GGAAGGGCATGGATGATGGAAGCCTGGAGCGGATCCTAGTTGGGGAGCTGCTCACATCCCAGCCTGAGGTGGATGAGAGGCCATGCCGGA
CCCCGCCGCTGCAGCAGTCCCCCAGTGTCATCCGGAGGCTTGTTACCATCTCACCCAACAACAAGCCCAAGCTGAACACTGGGCAGATCC
AGGAGTCCATCGGGGAGGCAGTCAATGGCATTGTGAAGCACTTCCATAAGCCTGAGAAAGAGCGAGGCAGTCTGACGCTGTTGCTCTGTG
GAGAGTGTGGCCTTGTCTCGGCCTTGGAACAGGCTTTCCAGCATGGATTTAAATCGCCCCGGCTCTTCAAAAATGTCTTCATTTGGGATT
TCCTGGAAAAAGCACAAACCTATTATGAGACATTAGAGAAGAATGAAGTAGTCCCTGAGGAAAACTGGCATACAAGAGCCCGGAACTTCT
GCCGATTTGTCACTGCAATCAACAATACTCCCCGGAACATCGGCAAGGATGAGATCACCTCCTACACCACTGGATTGCCCTGCTGGCTGA
CTGCCCCATCACTGCACACATGTATGAGGATGTGGCACTGATCAAAGACCATACACTTGTCAATTCCTTGATTCGTGTGCTGCAGACATT
GCAGGAGTTCAACATCACGCTGGAGACGTCCCTTGTCAAGGGCATCGACATCTGACCTCCCAGCACCAGCCAGCAGCAGGACTGAGAAAG
ACTCACCCTGCAGCTCTGACCTTTTTTCCCAAAGGGACTTAAGCGATTGTGCAGGAGTAGGAGACAAAATGTACACTCACTGTAAAAAGA

>79753_79753_8_SCUBE2-DENND5A_SCUBE2_chr11_9087438_ENST00000520467_DENND5A_chr11_9192324_ENST00000530044_length(amino acids)=897AA_BP=291
MPATAEPSMGVAGRNRPGAAWAVLLLLLLLPPLLLLAGAVPPGRGRAAGPQEDVDECAQGLDDCHADALCQNTPTSYKCSCKPGYQGEGR
QCEDIDECGNELNGGCVHDCLNIPGNYRCTCFDGFMLAHDGHNCLDVDECLENNGGCQHTCVNVMGSYECCCKEGFFLSDNQHTCIHRSE
EGLSCMNKDHGCSHICKEAPRGSVACECRPGFELAKNQRDCILTCNHGNGGCQHSCDDTADGPECSCHPQYKMHTDGRSCLEREDTVLEV
TESNTTSVVDGDKRVKRRLLMEKAIELRLAKIDHTAIHPHLLDMKIGQGKYEPGFFPKLQSDVLSTGPASNKWTKRNAPAQWRRKDRQKQ
HTEHLRLDNDQREKYIQEARTMGSTIRQPKLSNLSPSVIAQTNWKFVEGLLKECRNKTKRMLVEKMGREAVELGHGEVNITGVEENTLIA
SLCDLLERIWSHGLQVKQGKSALWSHLLHYQDNRQRKLTSGSLSTSGILLDSERRKSDASSLMPPLRISLIQDMRHIQNIGEIKTDVGKA
RAWVRLSMEKKLLSRHLKQLLSDHELTKKLYKRYAFLRCDDEKEQFLYHLLSFNAVDYFCFTNVFTTILIPYHILIVPSKKLGGSMFTAN
PWICISGELGETQIMQIPRNVLEMTFECQNLGKLTTVQIGHDNSGLYAKWLVEYVMVRNEITGHTYKFPCGRWLGKGMDDGSLERILVGE
LLTSQPEVDERPCRTPPLQQSPSVIRRLVTISPNNKPKLNTGQIQESIGEAVNGIVKHFHKPEKERGSLTLLLCGECGLVSALEQAFQHG

--------------------------------------------------------------

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Fusion Gene PPI Analysis for SCUBE2-DENND5A


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneSCUBE2chr11:9087438chr11:9192324ENST00000309263-722847_856283.33333333333331000.0the cholesterol-anchor of SHH
HgeneSCUBE2chr11:9087438chr11:9192324ENST00000450649-718847_856283.3333333333333808.0the cholesterol-anchor of SHH
HgeneSCUBE2chr11:9087438chr11:9192324ENST00000520467-722847_856283.3333333333333972.0the cholesterol-anchor of SHH


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for SCUBE2-DENND5A


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for SCUBE2-DENND5A


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource