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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:SCYL3-KIFAP3 (FusionGDB2 ID:79787)

Fusion Gene Summary for SCYL3-KIFAP3

check button Fusion gene summary
Fusion gene informationFusion gene name: SCYL3-KIFAP3
Fusion gene ID: 79787
HgeneTgene
Gene symbol

SCYL3

KIFAP3

Gene ID

57147

22920

Gene nameSCY1 like pseudokinase 3kinesin associated protein 3
SynonymsPACE-1|PACE1FLA3|KAP-1|KAP-3|KAP3|SMAP|Smg-GDS|dJ190I16.1
Cytomap

1q24.2

1q24.2

Type of geneprotein-codingprotein-coding
Descriptionprotein-associating with the carboxyl-terminal domain of ezrinSCY1-like 3SCY1-like protein 3SCY1-like, kinase-like 3ezrin-binding partner PACE-1 (PACE-1)ezrin-binding protein PACE-1kinesin-associated protein 3small G protein GDP dissociation stimulatorsmg GDS-associated protein
Modification date2020031320200313
UniProtAcc.

Q92845

Ensembl transtripts involved in fusion geneENST00000367770, ENST00000367771, 
ENST00000367772, ENST00000470238, 
ENST00000490550, ENST00000361580, 
ENST00000367765, ENST00000367767, 
ENST00000538366, ENST00000540905, 
Fusion gene scores* DoF score4 X 3 X 5=6010 X 9 X 7=630
# samples 59
** MAII scorelog2(5/60*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(9/630*10)=-2.8073549220576
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SCYL3 [Title/Abstract] AND KIFAP3 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointSCYL3(169842837)-KIFAP3(169923251), # samples:3
SCYL3(169857817)-KIFAP3(169985765), # samples:3
Anticipated loss of major functional domain due to fusion event.SCYL3-KIFAP3 seems lost the major protein functional domain in Hgene partner, which is a kinase due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across SCYL3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across KIFAP3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUSCTCGA-77-A5GH-01ASCYL3chr1

169842837

-KIFAP3chr1

169923251

-
ChimerDB4LUSCTCGA-77-A5GHSCYL3chr1

169842837

-KIFAP3chr1

169923251

-
ChimerDB4STADTCGA-BR-8297-01ASCYL3chr1

169857817

-KIFAP3chr1

169985765

-


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Fusion Gene ORF analysis for SCYL3-KIFAP3

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000367770ENST00000490550SCYL3chr1

169842837

-KIFAP3chr1

169923251

-
5CDS-intronENST00000367770ENST00000490550SCYL3chr1

169857817

-KIFAP3chr1

169985765

-
5CDS-intronENST00000367771ENST00000490550SCYL3chr1

169842837

-KIFAP3chr1

169923251

-
5CDS-intronENST00000367771ENST00000490550SCYL3chr1

169857817

-KIFAP3chr1

169985765

-
5CDS-intronENST00000367772ENST00000490550SCYL3chr1

169842837

-KIFAP3chr1

169923251

-
5CDS-intronENST00000367772ENST00000490550SCYL3chr1

169857817

-KIFAP3chr1

169985765

-
5UTR-3CDSENST00000470238ENST00000361580SCYL3chr1

169842837

-KIFAP3chr1

169923251

-
5UTR-3CDSENST00000470238ENST00000361580SCYL3chr1

169857817

-KIFAP3chr1

169985765

-
5UTR-3CDSENST00000470238ENST00000367765SCYL3chr1

169842837

-KIFAP3chr1

169923251

-
5UTR-3CDSENST00000470238ENST00000367765SCYL3chr1

169857817

-KIFAP3chr1

169985765

-
5UTR-3CDSENST00000470238ENST00000367767SCYL3chr1

169842837

-KIFAP3chr1

169923251

-
5UTR-3CDSENST00000470238ENST00000367767SCYL3chr1

169857817

-KIFAP3chr1

169985765

-
5UTR-3CDSENST00000470238ENST00000538366SCYL3chr1

169842837

-KIFAP3chr1

169923251

-
5UTR-3CDSENST00000470238ENST00000538366SCYL3chr1

169857817

-KIFAP3chr1

169985765

-
5UTR-3CDSENST00000470238ENST00000540905SCYL3chr1

169842837

-KIFAP3chr1

169923251

-
5UTR-3CDSENST00000470238ENST00000540905SCYL3chr1

169857817

-KIFAP3chr1

169985765

-
5UTR-intronENST00000470238ENST00000490550SCYL3chr1

169842837

-KIFAP3chr1

169923251

-
5UTR-intronENST00000470238ENST00000490550SCYL3chr1

169857817

-KIFAP3chr1

169985765

-
Frame-shiftENST00000367770ENST00000361580SCYL3chr1

169842837

-KIFAP3chr1

169923251

-
Frame-shiftENST00000367770ENST00000367765SCYL3chr1

169842837

-KIFAP3chr1

169923251

-
Frame-shiftENST00000367770ENST00000367767SCYL3chr1

169842837

-KIFAP3chr1

169923251

-
Frame-shiftENST00000367770ENST00000538366SCYL3chr1

169842837

-KIFAP3chr1

169923251

-
Frame-shiftENST00000367770ENST00000540905SCYL3chr1

169842837

-KIFAP3chr1

169923251

-
Frame-shiftENST00000367771ENST00000361580SCYL3chr1

169842837

-KIFAP3chr1

169923251

-
Frame-shiftENST00000367771ENST00000361580SCYL3chr1

169857817

-KIFAP3chr1

169985765

-
Frame-shiftENST00000367771ENST00000367765SCYL3chr1

169842837

-KIFAP3chr1

169923251

-
Frame-shiftENST00000367771ENST00000367765SCYL3chr1

169857817

-KIFAP3chr1

169985765

-
Frame-shiftENST00000367771ENST00000367767SCYL3chr1

169842837

-KIFAP3chr1

169923251

-
Frame-shiftENST00000367771ENST00000367767SCYL3chr1

169857817

-KIFAP3chr1

169985765

-
Frame-shiftENST00000367771ENST00000538366SCYL3chr1

169842837

-KIFAP3chr1

169923251

-
Frame-shiftENST00000367771ENST00000538366SCYL3chr1

169857817

-KIFAP3chr1

169985765

-
Frame-shiftENST00000367771ENST00000540905SCYL3chr1

169842837

-KIFAP3chr1

169923251

-
Frame-shiftENST00000367771ENST00000540905SCYL3chr1

169857817

-KIFAP3chr1

169985765

-
Frame-shiftENST00000367772ENST00000361580SCYL3chr1

169842837

-KIFAP3chr1

169923251

-
Frame-shiftENST00000367772ENST00000361580SCYL3chr1

169857817

-KIFAP3chr1

169985765

-
Frame-shiftENST00000367772ENST00000367765SCYL3chr1

169842837

-KIFAP3chr1

169923251

-
Frame-shiftENST00000367772ENST00000367765SCYL3chr1

169857817

-KIFAP3chr1

169985765

-
Frame-shiftENST00000367772ENST00000367767SCYL3chr1

169842837

-KIFAP3chr1

169923251

-
Frame-shiftENST00000367772ENST00000367767SCYL3chr1

169857817

-KIFAP3chr1

169985765

-
Frame-shiftENST00000367772ENST00000538366SCYL3chr1

169842837

-KIFAP3chr1

169923251

-
Frame-shiftENST00000367772ENST00000538366SCYL3chr1

169857817

-KIFAP3chr1

169985765

-
Frame-shiftENST00000367772ENST00000540905SCYL3chr1

169842837

-KIFAP3chr1

169923251

-
Frame-shiftENST00000367772ENST00000540905SCYL3chr1

169857817

-KIFAP3chr1

169985765

-
In-frameENST00000367770ENST00000361580SCYL3chr1

169857817

-KIFAP3chr1

169985765

-
In-frameENST00000367770ENST00000367765SCYL3chr1

169857817

-KIFAP3chr1

169985765

-
In-frameENST00000367770ENST00000367767SCYL3chr1

169857817

-KIFAP3chr1

169985765

-
In-frameENST00000367770ENST00000538366SCYL3chr1

169857817

-KIFAP3chr1

169985765

-
In-frameENST00000367770ENST00000540905SCYL3chr1

169857817

-KIFAP3chr1

169985765

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000367770SCYL3chr1169857817-ENST00000367765KIFAP3chr1169985765-1922213481571507
ENST00000367770SCYL3chr1169857817-ENST00000367767KIFAP3chr1169985765-1922213481571507
ENST00000367770SCYL3chr1169857817-ENST00000361580KIFAP3chr1169985765-1922213481571507
ENST00000367770SCYL3chr1169857817-ENST00000538366KIFAP3chr1169985765-1816213481571507
ENST00000367770SCYL3chr1169857817-ENST00000540905KIFAP3chr1169985765-1911213481571507

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000367770ENST00000367765SCYL3chr1169857817-KIFAP3chr1169985765-0.0003572580.9996427
ENST00000367770ENST00000367767SCYL3chr1169857817-KIFAP3chr1169985765-0.0003572580.9996427
ENST00000367770ENST00000361580SCYL3chr1169857817-KIFAP3chr1169985765-0.0003572580.9996427
ENST00000367770ENST00000538366SCYL3chr1169857817-KIFAP3chr1169985765-0.0004715460.9995285
ENST00000367770ENST00000540905SCYL3chr1169857817-KIFAP3chr1169985765-0.0003672780.9996327

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Fusion Genomic Features for SCYL3-KIFAP3


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for SCYL3-KIFAP3


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:169842837/chr1:169923251)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.KIFAP3

Q92845

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Involved in tethering the chromosomes to the spindle pole and in chromosome movement. Binds to the tail domain of the KIF3A/KIF3B heterodimer to form a heterotrimeric KIF3 complex and may regulate the membrane binding of this complex (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneKIFAP3chr1:169857817chr1:169985765ENST00000361580820374_412340793.0RepeatNote=ARM 2
TgeneKIFAP3chr1:169857817chr1:169985765ENST00000361580820494_533340793.0RepeatNote=ARM 3
TgeneKIFAP3chr1:169857817chr1:169985765ENST00000361580820578_620340793.0RepeatNote=ARM 4
TgeneKIFAP3chr1:169857817chr1:169985765ENST00000361580820621_662340793.0RepeatNote=ARM 5
TgeneKIFAP3chr1:169857817chr1:169985765ENST00000367765820333_373300753.0RepeatNote=ARM 1
TgeneKIFAP3chr1:169857817chr1:169985765ENST00000367765820374_412300753.0RepeatNote=ARM 2
TgeneKIFAP3chr1:169857817chr1:169985765ENST00000367765820494_533300753.0RepeatNote=ARM 3
TgeneKIFAP3chr1:169857817chr1:169985765ENST00000367765820578_620300753.0RepeatNote=ARM 4
TgeneKIFAP3chr1:169857817chr1:169985765ENST00000367765820621_662300753.0RepeatNote=ARM 5
TgeneKIFAP3chr1:169857817chr1:169985765ENST00000367767719333_373296749.0RepeatNote=ARM 1
TgeneKIFAP3chr1:169857817chr1:169985765ENST00000367767719374_412296749.0RepeatNote=ARM 2
TgeneKIFAP3chr1:169857817chr1:169985765ENST00000367767719494_533296749.0RepeatNote=ARM 3
TgeneKIFAP3chr1:169857817chr1:169985765ENST00000367767719578_620296749.0RepeatNote=ARM 4
TgeneKIFAP3chr1:169857817chr1:169985765ENST00000367767719621_662296749.0RepeatNote=ARM 5
TgeneKIFAP3chr1:169857817chr1:169985765ENST00000538366921333_373262715.0RepeatNote=ARM 1
TgeneKIFAP3chr1:169857817chr1:169985765ENST00000538366921374_412262715.0RepeatNote=ARM 2
TgeneKIFAP3chr1:169857817chr1:169985765ENST00000538366921494_533262715.0RepeatNote=ARM 3
TgeneKIFAP3chr1:169857817chr1:169985765ENST00000538366921578_620262715.0RepeatNote=ARM 4
TgeneKIFAP3chr1:169857817chr1:169985765ENST00000538366921621_662262715.0RepeatNote=ARM 5

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSCYL3chr1:169857817chr1:169985765ENST00000367770-1132_24555743.0DomainProtein kinase
HgeneSCYL3chr1:169857817chr1:169985765ENST00000367771-2132_24555689.0DomainProtein kinase
HgeneSCYL3chr1:169857817chr1:169985765ENST00000367772-2142_24555743.0DomainProtein kinase
HgeneSCYL3chr1:169857817chr1:169985765ENST00000367770-113199_23855743.0RepeatNote=HEAT 1
HgeneSCYL3chr1:169857817chr1:169985765ENST00000367770-113285_32355743.0RepeatNote=HEAT 2
HgeneSCYL3chr1:169857817chr1:169985765ENST00000367770-113333_37055743.0RepeatNote=HEAT 3
HgeneSCYL3chr1:169857817chr1:169985765ENST00000367770-113372_40955743.0RepeatNote=HEAT 4
HgeneSCYL3chr1:169857817chr1:169985765ENST00000367771-213199_23855689.0RepeatNote=HEAT 1
HgeneSCYL3chr1:169857817chr1:169985765ENST00000367771-213285_32355689.0RepeatNote=HEAT 2
HgeneSCYL3chr1:169857817chr1:169985765ENST00000367771-213333_37055689.0RepeatNote=HEAT 3
HgeneSCYL3chr1:169857817chr1:169985765ENST00000367771-213372_40955689.0RepeatNote=HEAT 4
HgeneSCYL3chr1:169857817chr1:169985765ENST00000367772-214199_23855743.0RepeatNote=HEAT 1
HgeneSCYL3chr1:169857817chr1:169985765ENST00000367772-214285_32355743.0RepeatNote=HEAT 2
HgeneSCYL3chr1:169857817chr1:169985765ENST00000367772-214333_37055743.0RepeatNote=HEAT 3
HgeneSCYL3chr1:169857817chr1:169985765ENST00000367772-214372_40955743.0RepeatNote=HEAT 4
TgeneKIFAP3chr1:169857817chr1:169985765ENST00000361580820333_373340793.0RepeatNote=ARM 1


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Fusion Gene Sequence for SCYL3-KIFAP3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>79787_79787_1_SCYL3-KIFAP3_SCYL3_chr1_169857817_ENST00000367770_KIFAP3_chr1_169985765_ENST00000361580_length(transcript)=1922nt_BP=213nt
CTGCTTGGCTTTGAGGAAGAGTGGCAGTACTGCCTCACTGCATAAGGGATGGGATCAGAGAACAGTGCTTTAAAGAGCTATACACTGAGA
GAACCACCATTTACCTTACCCTCTGGACTTGCTGTTTATCCCGCTGTACTGCAAGATGGCAAATTTGCTTCAGTTTTTGTGTATAAGAGA
GAAAATGAAGACAAGGTTAATAAAGCTGCCAAGGTGGAAATGGATATTGTTGAAAAACTGGTGAAAATGATACCTTGTGAGCATGAAGAC
CTGCTGAATATCACCCTCCGACTTTTACTAAACCTATCCTTTGACACAGGACTGAGGAATAAGATGGTACAAGTTGGACTGCTTCCCAAG
CTCACTGCACTCCTAGGCAATGACAACTACAAACAAATAGCAATGTGTGTTCTTTACCACATAAGCATGGATGACCGCTTTAAATCAATG
TTTGCATACACTGACTGTATACCACAGTTAATGAAGATGCTGTTTGAATGTTCAGATGAACGAATTGACTTGGAACTCATTTCTTTCTGC
ATTAATCTTGCTGCTAACAAAAGAAATGTACAGCTTATCTGTGAAGGAAATGGGCTGAAGATGCTCATGAAGAGGGCTCTGAAGTTTAAG
GATCCATTGCTGATGAAAATGATTAGAAACATTTCTCAGCATGATGGACCAACTAAAAATCTGTTTATTGATTATGTTGGGGACCTTGCA
GCCCAGATCTCTAATGATGAAGAAGAGGAGTTTGTGATTGAATGTTTGGGAACTCTTGCAAACTTGACCATTCCAGACTTAGACTGGGAA
TTGGTTCTTAAAGAATATAAGTTGGTTCCATACCTCAAGGATAAACTAAAACCAGGTGCTGCAGAAGATGATCTTGTTTTAGAAGTGGTT
ATAATGATTGGAACTGTATCCATGGATGACTCTTGTGCTGCATTGCTAGCCAAATCTGGCATAATCCCTGCACTCATTGAATTGCTAAAT
GCTCAACAAGAAGATGATGAATTTGTGTGTCAGATAATTTATGTCTTCTACCAGATGGTTTTCCACCAAGCCACAAGAGACGTCATAATC
AAGGAAACACAGGCTCCAGCATATCTCATAGACCTAATGCATGATAAGAATAATGAAATCCGAAAGGTCTGTGATAATACATTAGATATT
ATAGCGGAATATGATGAAGAATGGGCTAAGAAAATTCAGAGTGAAAAGTTTCGCTGGCATAACTCTCAGTGGCTGGAGATGGTAGAGAGT
CGTCAGATGGATGAGAGTGAGCAGTACTTGTATGGTGATGATCGAATTGAGCCATACATTCATGAAGGAGATATTCTCGAAAGACCTGAC
CTTTTCTACAACTCAGATGGATTAATTGCCTCTGAAGGAGCCATAAGTCCCGATTTCTTCAATGATTACCACCTTCAAAATGGAGATGTT
GTTGGGCAGCATTCATTTCCTGGCAGCCTTGGAATGGATGGCTTTGGCCAACCAGTTGGCATTCTTGGACGCCCTGCCACAGCATATGGA
TTCCGCCCTGATGAACCTTACTACTATGGCTATGGATCTTGATAAAGTATCTGTTTCCATGTGTAATCTCAGCTTAGAAGAAATCTGTGT
GGGTTGGGTTAATTTTGGATCTTTGCCTAATAATGCATGTTGATGTTATTGTGGGTCTGTGTTTGTTTTTATTTTTATATGTTGTTAGCT
GCAGATTAACCCCAGCCCCTCTGTCTTCTGTTAAGTACAGTTGATACTGACATTGTTCACTCATCAAACCACATCTTGATGCTAAGTAAC
ATTTCCCATGAGCCACAAAACTGAATGCTGAAAAGCTACTAGACTGGAAAACAAACACTGCATTATGTATGTTAAGTGACTAATTTAATT

>79787_79787_1_SCYL3-KIFAP3_SCYL3_chr1_169857817_ENST00000367770_KIFAP3_chr1_169985765_ENST00000361580_length(amino acids)=507AA_BP=55
MGSENSALKSYTLREPPFTLPSGLAVYPAVLQDGKFASVFVYKRENEDKVNKAAKVEMDIVEKLVKMIPCEHEDLLNITLRLLLNLSFDT
GLRNKMVQVGLLPKLTALLGNDNYKQIAMCVLYHISMDDRFKSMFAYTDCIPQLMKMLFECSDERIDLELISFCINLAANKRNVQLICEG
NGLKMLMKRALKFKDPLLMKMIRNISQHDGPTKNLFIDYVGDLAAQISNDEEEEFVIECLGTLANLTIPDLDWELVLKEYKLVPYLKDKL
KPGAAEDDLVLEVVIMIGTVSMDDSCAALLAKSGIIPALIELLNAQQEDDEFVCQIIYVFYQMVFHQATRDVIIKETQAPAYLIDLMHDK
NNEIRKVCDNTLDIIAEYDEEWAKKIQSEKFRWHNSQWLEMVESRQMDESEQYLYGDDRIEPYIHEGDILERPDLFYNSDGLIASEGAIS

--------------------------------------------------------------
>79787_79787_2_SCYL3-KIFAP3_SCYL3_chr1_169857817_ENST00000367770_KIFAP3_chr1_169985765_ENST00000367765_length(transcript)=1922nt_BP=213nt
CTGCTTGGCTTTGAGGAAGAGTGGCAGTACTGCCTCACTGCATAAGGGATGGGATCAGAGAACAGTGCTTTAAAGAGCTATACACTGAGA
GAACCACCATTTACCTTACCCTCTGGACTTGCTGTTTATCCCGCTGTACTGCAAGATGGCAAATTTGCTTCAGTTTTTGTGTATAAGAGA
GAAAATGAAGACAAGGTTAATAAAGCTGCCAAGGTGGAAATGGATATTGTTGAAAAACTGGTGAAAATGATACCTTGTGAGCATGAAGAC
CTGCTGAATATCACCCTCCGACTTTTACTAAACCTATCCTTTGACACAGGACTGAGGAATAAGATGGTACAAGTTGGACTGCTTCCCAAG
CTCACTGCACTCCTAGGCAATGACAACTACAAACAAATAGCAATGTGTGTTCTTTACCACATAAGCATGGATGACCGCTTTAAATCAATG
TTTGCATACACTGACTGTATACCACAGTTAATGAAGATGCTGTTTGAATGTTCAGATGAACGAATTGACTTGGAACTCATTTCTTTCTGC
ATTAATCTTGCTGCTAACAAAAGAAATGTACAGCTTATCTGTGAAGGAAATGGGCTGAAGATGCTCATGAAGAGGGCTCTGAAGTTTAAG
GATCCATTGCTGATGAAAATGATTAGAAACATTTCTCAGCATGATGGACCAACTAAAAATCTGTTTATTGATTATGTTGGGGACCTTGCA
GCCCAGATCTCTAATGATGAAGAAGAGGAGTTTGTGATTGAATGTTTGGGAACTCTTGCAAACTTGACCATTCCAGACTTAGACTGGGAA
TTGGTTCTTAAAGAATATAAGTTGGTTCCATACCTCAAGGATAAACTAAAACCAGGTGCTGCAGAAGATGATCTTGTTTTAGAAGTGGTT
ATAATGATTGGAACTGTATCCATGGATGACTCTTGTGCTGCATTGCTAGCCAAATCTGGCATAATCCCTGCACTCATTGAATTGCTAAAT
GCTCAACAAGAAGATGATGAATTTGTGTGTCAGATAATTTATGTCTTCTACCAGATGGTTTTCCACCAAGCCACAAGAGACGTCATAATC
AAGGAAACACAGGCTCCAGCATATCTCATAGACCTAATGCATGATAAGAATAATGAAATCCGAAAGGTCTGTGATAATACATTAGATATT
ATAGCGGAATATGATGAAGAATGGGCTAAGAAAATTCAGAGTGAAAAGTTTCGCTGGCATAACTCTCAGTGGCTGGAGATGGTAGAGAGT
CGTCAGATGGATGAGAGTGAGCAGTACTTGTATGGTGATGATCGAATTGAGCCATACATTCATGAAGGAGATATTCTCGAAAGACCTGAC
CTTTTCTACAACTCAGATGGATTAATTGCCTCTGAAGGAGCCATAAGTCCCGATTTCTTCAATGATTACCACCTTCAAAATGGAGATGTT
GTTGGGCAGCATTCATTTCCTGGCAGCCTTGGAATGGATGGCTTTGGCCAACCAGTTGGCATTCTTGGACGCCCTGCCACAGCATATGGA
TTCCGCCCTGATGAACCTTACTACTATGGCTATGGATCTTGATAAAGTATCTGTTTCCATGTGTAATCTCAGCTTAGAAGAAATCTGTGT
GGGTTGGGTTAATTTTGGATCTTTGCCTAATAATGCATGTTGATGTTATTGTGGGTCTGTGTTTGTTTTTATTTTTATATGTTGTTAGCT
GCAGATTAACCCCAGCCCCTCTGTCTTCTGTTAAGTACAGTTGATACTGACATTGTTCACTCATCAAACCACATCTTGATGCTAAGTAAC
ATTTCCCATGAGCCACAAAACTGAATGCTGAAAAGCTACTAGACTGGAAAACAAACACTGCATTATGTATGTTAAGTGACTAATTTAATT

>79787_79787_2_SCYL3-KIFAP3_SCYL3_chr1_169857817_ENST00000367770_KIFAP3_chr1_169985765_ENST00000367765_length(amino acids)=507AA_BP=55
MGSENSALKSYTLREPPFTLPSGLAVYPAVLQDGKFASVFVYKRENEDKVNKAAKVEMDIVEKLVKMIPCEHEDLLNITLRLLLNLSFDT
GLRNKMVQVGLLPKLTALLGNDNYKQIAMCVLYHISMDDRFKSMFAYTDCIPQLMKMLFECSDERIDLELISFCINLAANKRNVQLICEG
NGLKMLMKRALKFKDPLLMKMIRNISQHDGPTKNLFIDYVGDLAAQISNDEEEEFVIECLGTLANLTIPDLDWELVLKEYKLVPYLKDKL
KPGAAEDDLVLEVVIMIGTVSMDDSCAALLAKSGIIPALIELLNAQQEDDEFVCQIIYVFYQMVFHQATRDVIIKETQAPAYLIDLMHDK
NNEIRKVCDNTLDIIAEYDEEWAKKIQSEKFRWHNSQWLEMVESRQMDESEQYLYGDDRIEPYIHEGDILERPDLFYNSDGLIASEGAIS

--------------------------------------------------------------
>79787_79787_3_SCYL3-KIFAP3_SCYL3_chr1_169857817_ENST00000367770_KIFAP3_chr1_169985765_ENST00000367767_length(transcript)=1922nt_BP=213nt
CTGCTTGGCTTTGAGGAAGAGTGGCAGTACTGCCTCACTGCATAAGGGATGGGATCAGAGAACAGTGCTTTAAAGAGCTATACACTGAGA
GAACCACCATTTACCTTACCCTCTGGACTTGCTGTTTATCCCGCTGTACTGCAAGATGGCAAATTTGCTTCAGTTTTTGTGTATAAGAGA
GAAAATGAAGACAAGGTTAATAAAGCTGCCAAGGTGGAAATGGATATTGTTGAAAAACTGGTGAAAATGATACCTTGTGAGCATGAAGAC
CTGCTGAATATCACCCTCCGACTTTTACTAAACCTATCCTTTGACACAGGACTGAGGAATAAGATGGTACAAGTTGGACTGCTTCCCAAG
CTCACTGCACTCCTAGGCAATGACAACTACAAACAAATAGCAATGTGTGTTCTTTACCACATAAGCATGGATGACCGCTTTAAATCAATG
TTTGCATACACTGACTGTATACCACAGTTAATGAAGATGCTGTTTGAATGTTCAGATGAACGAATTGACTTGGAACTCATTTCTTTCTGC
ATTAATCTTGCTGCTAACAAAAGAAATGTACAGCTTATCTGTGAAGGAAATGGGCTGAAGATGCTCATGAAGAGGGCTCTGAAGTTTAAG
GATCCATTGCTGATGAAAATGATTAGAAACATTTCTCAGCATGATGGACCAACTAAAAATCTGTTTATTGATTATGTTGGGGACCTTGCA
GCCCAGATCTCTAATGATGAAGAAGAGGAGTTTGTGATTGAATGTTTGGGAACTCTTGCAAACTTGACCATTCCAGACTTAGACTGGGAA
TTGGTTCTTAAAGAATATAAGTTGGTTCCATACCTCAAGGATAAACTAAAACCAGGTGCTGCAGAAGATGATCTTGTTTTAGAAGTGGTT
ATAATGATTGGAACTGTATCCATGGATGACTCTTGTGCTGCATTGCTAGCCAAATCTGGCATAATCCCTGCACTCATTGAATTGCTAAAT
GCTCAACAAGAAGATGATGAATTTGTGTGTCAGATAATTTATGTCTTCTACCAGATGGTTTTCCACCAAGCCACAAGAGACGTCATAATC
AAGGAAACACAGGCTCCAGCATATCTCATAGACCTAATGCATGATAAGAATAATGAAATCCGAAAGGTCTGTGATAATACATTAGATATT
ATAGCGGAATATGATGAAGAATGGGCTAAGAAAATTCAGAGTGAAAAGTTTCGCTGGCATAACTCTCAGTGGCTGGAGATGGTAGAGAGT
CGTCAGATGGATGAGAGTGAGCAGTACTTGTATGGTGATGATCGAATTGAGCCATACATTCATGAAGGAGATATTCTCGAAAGACCTGAC
CTTTTCTACAACTCAGATGGATTAATTGCCTCTGAAGGAGCCATAAGTCCCGATTTCTTCAATGATTACCACCTTCAAAATGGAGATGTT
GTTGGGCAGCATTCATTTCCTGGCAGCCTTGGAATGGATGGCTTTGGCCAACCAGTTGGCATTCTTGGACGCCCTGCCACAGCATATGGA
TTCCGCCCTGATGAACCTTACTACTATGGCTATGGATCTTGATAAAGTATCTGTTTCCATGTGTAATCTCAGCTTAGAAGAAATCTGTGT
GGGTTGGGTTAATTTTGGATCTTTGCCTAATAATGCATGTTGATGTTATTGTGGGTCTGTGTTTGTTTTTATTTTTATATGTTGTTAGCT
GCAGATTAACCCCAGCCCCTCTGTCTTCTGTTAAGTACAGTTGATACTGACATTGTTCACTCATCAAACCACATCTTGATGCTAAGTAAC
ATTTCCCATGAGCCACAAAACTGAATGCTGAAAAGCTACTAGACTGGAAAACAAACACTGCATTATGTATGTTAAGTGACTAATTTAATT

>79787_79787_3_SCYL3-KIFAP3_SCYL3_chr1_169857817_ENST00000367770_KIFAP3_chr1_169985765_ENST00000367767_length(amino acids)=507AA_BP=55
MGSENSALKSYTLREPPFTLPSGLAVYPAVLQDGKFASVFVYKRENEDKVNKAAKVEMDIVEKLVKMIPCEHEDLLNITLRLLLNLSFDT
GLRNKMVQVGLLPKLTALLGNDNYKQIAMCVLYHISMDDRFKSMFAYTDCIPQLMKMLFECSDERIDLELISFCINLAANKRNVQLICEG
NGLKMLMKRALKFKDPLLMKMIRNISQHDGPTKNLFIDYVGDLAAQISNDEEEEFVIECLGTLANLTIPDLDWELVLKEYKLVPYLKDKL
KPGAAEDDLVLEVVIMIGTVSMDDSCAALLAKSGIIPALIELLNAQQEDDEFVCQIIYVFYQMVFHQATRDVIIKETQAPAYLIDLMHDK
NNEIRKVCDNTLDIIAEYDEEWAKKIQSEKFRWHNSQWLEMVESRQMDESEQYLYGDDRIEPYIHEGDILERPDLFYNSDGLIASEGAIS

--------------------------------------------------------------
>79787_79787_4_SCYL3-KIFAP3_SCYL3_chr1_169857817_ENST00000367770_KIFAP3_chr1_169985765_ENST00000538366_length(transcript)=1816nt_BP=213nt
CTGCTTGGCTTTGAGGAAGAGTGGCAGTACTGCCTCACTGCATAAGGGATGGGATCAGAGAACAGTGCTTTAAAGAGCTATACACTGAGA
GAACCACCATTTACCTTACCCTCTGGACTTGCTGTTTATCCCGCTGTACTGCAAGATGGCAAATTTGCTTCAGTTTTTGTGTATAAGAGA
GAAAATGAAGACAAGGTTAATAAAGCTGCCAAGGTGGAAATGGATATTGTTGAAAAACTGGTGAAAATGATACCTTGTGAGCATGAAGAC
CTGCTGAATATCACCCTCCGACTTTTACTAAACCTATCCTTTGACACAGGACTGAGGAATAAGATGGTACAAGTTGGACTGCTTCCCAAG
CTCACTGCACTCCTAGGCAATGACAACTACAAACAAATAGCAATGTGTGTTCTTTACCACATAAGCATGGATGACCGCTTTAAATCAATG
TTTGCATACACTGACTGTATACCACAGTTAATGAAGATGCTGTTTGAATGTTCAGATGAACGAATTGACTTGGAACTCATTTCTTTCTGC
ATTAATCTTGCTGCTAACAAAAGAAATGTACAGCTTATCTGTGAAGGAAATGGGCTGAAGATGCTCATGAAGAGGGCTCTGAAGTTTAAG
GATCCATTGCTGATGAAAATGATTAGAAACATTTCTCAGCATGATGGACCAACTAAAAATCTGTTTATTGATTATGTTGGGGACCTTGCA
GCCCAGATCTCTAATGATGAAGAAGAGGAGTTTGTGATTGAATGTTTGGGAACTCTTGCAAACTTGACCATTCCAGACTTAGACTGGGAA
TTGGTTCTTAAAGAATATAAGTTGGTTCCATACCTCAAGGATAAACTAAAACCAGGTGCTGCAGAAGATGATCTTGTTTTAGAAGTGGTT
ATAATGATTGGAACTGTATCCATGGATGACTCTTGTGCTGCATTGCTAGCCAAATCTGGCATAATCCCTGCACTCATTGAATTGCTAAAT
GCTCAACAAGAAGATGATGAATTTGTGTGTCAGATAATTTATGTCTTCTACCAGATGGTTTTCCACCAAGCCACAAGAGACGTCATAATC
AAGGAAACACAGGCTCCAGCATATCTCATAGACCTAATGCATGATAAGAATAATGAAATCCGAAAGGTCTGTGATAATACATTAGATATT
ATAGCGGAATATGATGAAGAATGGGCTAAGAAAATTCAGAGTGAAAAGTTTCGCTGGCATAACTCTCAGTGGCTGGAGATGGTAGAGAGT
CGTCAGATGGATGAGAGTGAGCAGTACTTGTATGGTGATGATCGAATTGAGCCATACATTCATGAAGGAGATATTCTCGAAAGACCTGAC
CTTTTCTACAACTCAGATGGATTAATTGCCTCTGAAGGAGCCATAAGTCCCGATTTCTTCAATGATTACCACCTTCAAAATGGAGATGTT
GTTGGGCAGCATTCATTTCCTGGCAGCCTTGGAATGGATGGCTTTGGCCAACCAGTTGGCATTCTTGGACGCCCTGCCACAGCATATGGA
TTCCGCCCTGATGAACCTTACTACTATGGCTATGGATCTTGATAAAGTATCTGTTTCCATGTGTAATCTCAGCTTAGAAGAAATCTGTGT
GGGTTGGGTTAATTTTGGATCTTTGCCTAATAATGCATGTTGATGTTATTGTGGGTCTGTGTTTGTTTTTATTTTTATATGTTGTTAGCT
GCAGATTAACCCCAGCCCCTCTGTCTTCTGTTAAGTACAGTTGATACTGACATTGTTCACTCATCAAACCACATCTTGATGCTAAGTAAC

>79787_79787_4_SCYL3-KIFAP3_SCYL3_chr1_169857817_ENST00000367770_KIFAP3_chr1_169985765_ENST00000538366_length(amino acids)=507AA_BP=55
MGSENSALKSYTLREPPFTLPSGLAVYPAVLQDGKFASVFVYKRENEDKVNKAAKVEMDIVEKLVKMIPCEHEDLLNITLRLLLNLSFDT
GLRNKMVQVGLLPKLTALLGNDNYKQIAMCVLYHISMDDRFKSMFAYTDCIPQLMKMLFECSDERIDLELISFCINLAANKRNVQLICEG
NGLKMLMKRALKFKDPLLMKMIRNISQHDGPTKNLFIDYVGDLAAQISNDEEEEFVIECLGTLANLTIPDLDWELVLKEYKLVPYLKDKL
KPGAAEDDLVLEVVIMIGTVSMDDSCAALLAKSGIIPALIELLNAQQEDDEFVCQIIYVFYQMVFHQATRDVIIKETQAPAYLIDLMHDK
NNEIRKVCDNTLDIIAEYDEEWAKKIQSEKFRWHNSQWLEMVESRQMDESEQYLYGDDRIEPYIHEGDILERPDLFYNSDGLIASEGAIS

--------------------------------------------------------------
>79787_79787_5_SCYL3-KIFAP3_SCYL3_chr1_169857817_ENST00000367770_KIFAP3_chr1_169985765_ENST00000540905_length(transcript)=1911nt_BP=213nt
CTGCTTGGCTTTGAGGAAGAGTGGCAGTACTGCCTCACTGCATAAGGGATGGGATCAGAGAACAGTGCTTTAAAGAGCTATACACTGAGA
GAACCACCATTTACCTTACCCTCTGGACTTGCTGTTTATCCCGCTGTACTGCAAGATGGCAAATTTGCTTCAGTTTTTGTGTATAAGAGA
GAAAATGAAGACAAGGTTAATAAAGCTGCCAAGGTGGAAATGGATATTGTTGAAAAACTGGTGAAAATGATACCTTGTGAGCATGAAGAC
CTGCTGAATATCACCCTCCGACTTTTACTAAACCTATCCTTTGACACAGGACTGAGGAATAAGATGGTACAAGTTGGACTGCTTCCCAAG
CTCACTGCACTCCTAGGCAATGACAACTACAAACAAATAGCAATGTGTGTTCTTTACCACATAAGCATGGATGACCGCTTTAAATCAATG
TTTGCATACACTGACTGTATACCACAGTTAATGAAGATGCTGTTTGAATGTTCAGATGAACGAATTGACTTGGAACTCATTTCTTTCTGC
ATTAATCTTGCTGCTAACAAAAGAAATGTACAGCTTATCTGTGAAGGAAATGGGCTGAAGATGCTCATGAAGAGGGCTCTGAAGTTTAAG
GATCCATTGCTGATGAAAATGATTAGAAACATTTCTCAGCATGATGGACCAACTAAAAATCTGTTTATTGATTATGTTGGGGACCTTGCA
GCCCAGATCTCTAATGATGAAGAAGAGGAGTTTGTGATTGAATGTTTGGGAACTCTTGCAAACTTGACCATTCCAGACTTAGACTGGGAA
TTGGTTCTTAAAGAATATAAGTTGGTTCCATACCTCAAGGATAAACTAAAACCAGGTGCTGCAGAAGATGATCTTGTTTTAGAAGTGGTT
ATAATGATTGGAACTGTATCCATGGATGACTCTTGTGCTGCATTGCTAGCCAAATCTGGCATAATCCCTGCACTCATTGAATTGCTAAAT
GCTCAACAAGAAGATGATGAATTTGTGTGTCAGATAATTTATGTCTTCTACCAGATGGTTTTCCACCAAGCCACAAGAGACGTCATAATC
AAGGAAACACAGGCTCCAGCATATCTCATAGACCTAATGCATGATAAGAATAATGAAATCCGAAAGGTCTGTGATAATACATTAGATATT
ATAGCGGAATATGATGAAGAATGGGCTAAGAAAATTCAGAGTGAAAAGTTTCGCTGGCATAACTCTCAGTGGCTGGAGATGGTAGAGAGT
CGTCAGATGGATGAGAGTGAGCAGTACTTGTATGGTGATGATCGAATTGAGCCATACATTCATGAAGGAGATATTCTCGAAAGACCTGAC
CTTTTCTACAACTCAGATGGATTAATTGCCTCTGAAGGAGCCATAAGTCCCGATTTCTTCAATGATTACCACCTTCAAAATGGAGATGTT
GTTGGGCAGCATTCATTTCCTGGCAGCCTTGGAATGGATGGCTTTGGCCAACCAGTTGGCATTCTTGGACGCCCTGCCACAGCATATGGA
TTCCGCCCTGATGAACCTTACTACTATGGCTATGGATCTTGATAAAGTATCTGTTTCCATGTGTAATCTCAGCTTAGAAGAAATCTGTGT
GGGTTGGGTTAATTTTGGATCTTTGCCTAATAATGCATGTTGATGTTATTGTGGGTCTGTGTTTGTTTTTATTTTTATATGTTGTTAGCT
GCAGATTAACCCCAGCCCCTCTGTCTTCTGTTAAGTACAGTTGATACTGACATTGTTCACTCATCAAACCACATCTTGATGCTAAGTAAC
ATTTCCCATGAGCCACAAAACTGAATGCTGAAAAGCTACTAGACTGGAAAACAAACACTGCATTATGTATGTTAAGTGACTAATTTAATT

>79787_79787_5_SCYL3-KIFAP3_SCYL3_chr1_169857817_ENST00000367770_KIFAP3_chr1_169985765_ENST00000540905_length(amino acids)=507AA_BP=55
MGSENSALKSYTLREPPFTLPSGLAVYPAVLQDGKFASVFVYKRENEDKVNKAAKVEMDIVEKLVKMIPCEHEDLLNITLRLLLNLSFDT
GLRNKMVQVGLLPKLTALLGNDNYKQIAMCVLYHISMDDRFKSMFAYTDCIPQLMKMLFECSDERIDLELISFCINLAANKRNVQLICEG
NGLKMLMKRALKFKDPLLMKMIRNISQHDGPTKNLFIDYVGDLAAQISNDEEEEFVIECLGTLANLTIPDLDWELVLKEYKLVPYLKDKL
KPGAAEDDLVLEVVIMIGTVSMDDSCAALLAKSGIIPALIELLNAQQEDDEFVCQIIYVFYQMVFHQATRDVIIKETQAPAYLIDLMHDK
NNEIRKVCDNTLDIIAEYDEEWAKKIQSEKFRWHNSQWLEMVESRQMDESEQYLYGDDRIEPYIHEGDILERPDLFYNSDGLIASEGAIS

--------------------------------------------------------------

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Fusion Gene PPI Analysis for SCYL3-KIFAP3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneSCYL3chr1:169857817chr1:169985765ENST00000367770-113548_74255.0743.0EZR
HgeneSCYL3chr1:169857817chr1:169985765ENST00000367771-213548_74255.0689.0EZR
HgeneSCYL3chr1:169857817chr1:169985765ENST00000367772-214548_74255.0743.0EZR


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for SCYL3-KIFAP3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for SCYL3-KIFAP3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource