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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:SDCCAG8-TFB2M (FusionGDB2 ID:79855)

Fusion Gene Summary for SDCCAG8-TFB2M

check button Fusion gene summary
Fusion gene informationFusion gene name: SDCCAG8-TFB2M
Fusion gene ID: 79855
HgeneTgene
Gene symbol

SDCCAG8

TFB2M

Gene ID

10806

64216

Gene nameSHH signaling and ciliogenesis regulator SDCCAG8transcription factor B2, mitochondrial
SynonymsBBS16|CCCAP|CCCAP SLSN7|HSPC085|NPHP10|NY-CO-8|SLSN7|hCCCAPHkp1|mtTFB2
Cytomap

1q43-q44

1q44

Type of geneprotein-codingprotein-coding
Descriptionserologically defined colon cancer antigen 8Bardet-Biedl syndrome 16antigen NY-CO-8centrosomal colon cancer autoantigen proteinnephrocystin 10dimethyladenosine transferase 2, mitochondrialHCV NS5A-transactivated protein 5S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase 2h-mtTFBh-mtTFB2hTFB2Mhepatitis C virus NS5A-transactivated protein 5mitochondrial 12S rRNA dimethylase
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000355875, ENST00000366541, 
ENST00000391846, ENST00000343783, 
ENST00000496361, 		ENST00000544618, 
ENST00000366514, 
Fusion gene scores* DoF score12 X 9 X 7=7564 X 5 X 5=100
# samples 135
** MAII scorelog2(13/756*10)=-2.53987461119262
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(5/100*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SDCCAG8 [Title/Abstract] AND TFB2M [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointSDCCAG8(243437958)-TFB2M(246714604), # samples:3
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneTFB2M

GO:0006390

mitochondrial transcription

12068295

TgeneTFB2M

GO:0006391

transcription initiation from mitochondrial promoter

20410300|29149603

TgeneTFB2M

GO:0045893

positive regulation of transcription, DNA-templated

20410300


check buttonFusion gene breakpoints across SDCCAG8 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across TFB2M (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SKCMTCGA-ER-A197-06ASDCCAG8chr1

243437958

-TFB2Mchr1

246714604

-
ChimerDB4SKCMTCGA-ER-A197-06ASDCCAG8chr1

243437958

+TFB2Mchr1

246714604

-


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Fusion Gene ORF analysis for SDCCAG8-TFB2M

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000355875ENST00000544618SDCCAG8chr1

243437958

+TFB2Mchr1

246714604

-
5CDS-3UTRENST00000366541ENST00000544618SDCCAG8chr1

243437958

+TFB2Mchr1

246714604

-
5CDS-3UTRENST00000391846ENST00000544618SDCCAG8chr1

243437958

+TFB2Mchr1

246714604

-
In-frameENST00000355875ENST00000366514SDCCAG8chr1

243437958

+TFB2Mchr1

246714604

-
In-frameENST00000366541ENST00000366514SDCCAG8chr1

243437958

+TFB2Mchr1

246714604

-
In-frameENST00000391846ENST00000366514SDCCAG8chr1

243437958

+TFB2Mchr1

246714604

-
intron-3CDSENST00000343783ENST00000366514SDCCAG8chr1

243437958

+TFB2Mchr1

246714604

-
intron-3CDSENST00000496361ENST00000366514SDCCAG8chr1

243437958

+TFB2Mchr1

246714604

-
intron-3UTRENST00000343783ENST00000544618SDCCAG8chr1

243437958

+TFB2Mchr1

246714604

-
intron-3UTRENST00000496361ENST00000544618SDCCAG8chr1

243437958

+TFB2Mchr1

246714604

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000355875SDCCAG8chr1243437958+ENST00000366514TFB2Mchr1246714604-15335761561061301
ENST00000366541SDCCAG8chr1243437958+ENST00000366514TFB2Mchr1246714604-14955381181023301
ENST00000391846SDCCAG8chr1243437958+ENST00000366514TFB2Mchr1246714604-15335761561061301

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000355875ENST00000366514SDCCAG8chr1243437958+TFB2Mchr1246714604-0.0012891020.9987109
ENST00000366541ENST00000366514SDCCAG8chr1243437958+TFB2Mchr1246714604-0.0010954270.9989046
ENST00000391846ENST00000366514SDCCAG8chr1243437958+TFB2Mchr1246714604-0.0012891020.9987109

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Fusion Genomic Features for SDCCAG8-TFB2M


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for SDCCAG8-TFB2M


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:243437958/chr1:246714604)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneTFB2Mchr1:243437958chr1:246714604ENST0000036651438330_331235397.0RegionDNA binding

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSDCCAG8chr1:243437958chr1:246714604ENST00000366541+418129_175140714.0Coiled coilOntology_term=ECO:0000255
HgeneSDCCAG8chr1:243437958chr1:246714604ENST00000366541+418223_273140714.0Coiled coilOntology_term=ECO:0000255
HgeneSDCCAG8chr1:243437958chr1:246714604ENST00000366541+418348_707140714.0Coiled coilOntology_term=ECO:0000255
HgeneSDCCAG8chr1:243437958chr1:246714604ENST00000391846+410129_175140361.0Coiled coilOntology_term=ECO:0000255
HgeneSDCCAG8chr1:243437958chr1:246714604ENST00000391846+410223_273140361.0Coiled coilOntology_term=ECO:0000255
HgeneSDCCAG8chr1:243437958chr1:246714604ENST00000391846+410348_707140361.0Coiled coilOntology_term=ECO:0000255
HgeneSDCCAG8chr1:243437958chr1:246714604ENST00000366541+418534_692140714.0Compositional biasNote=Gln-rich
HgeneSDCCAG8chr1:243437958chr1:246714604ENST00000391846+410534_692140361.0Compositional biasNote=Gln-rich
HgeneSDCCAG8chr1:243437958chr1:246714604ENST00000366541+418216_713140714.0RegionSufficient for homodimerization
HgeneSDCCAG8chr1:243437958chr1:246714604ENST00000391846+410216_713140361.0RegionSufficient for homodimerization


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Fusion Gene Sequence for SDCCAG8-TFB2M


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>79855_79855_1_SDCCAG8-TFB2M_SDCCAG8_chr1_243437958_ENST00000355875_TFB2M_chr1_246714604_ENST00000366514_length(transcript)=1533nt_BP=576nt
AGCCCCCAAGAGCTCTGTGCGGGATTCTAGGCTCCCCTGTGACAGCCGCGGCAGGAAGCAGGCGGGCGCTCCCCGGCCACAGGCCTGTTG
TTCTCGGAAGGGAGAAAGCTGGACATTTCCCCACGTAACTCCCAGCTCTGGGCCTAGAGTGCGTGCATGGCGAAGTCCCCGGAGAACTCT
ACCCTGGAGGAGATTCTGGGGCAGTATCAACGGAGTCTCCGGGAACATGCCAGCAGAAGCATTCACCAACTGACATGTGCCCTGAAAGAA
GGCGATGTCACTATTGGAGAAGATGCACCAAATCTTTCTTTTAGCACCAGTGTGGGAAATGAGGACGCCAGGACAGCCTGGCCCGAATTA
CAACAGAGCCATGCTGTTAATCAGCTCAAAGATTTGTTGCGCCAACAAGCAGATAAGGAAAGTGAAGTATCTCCGTCAAGAAGAAGAAAA
ATGTCCCCCTTGAGGTCATTAGAACATGAGGAAACCAATATGCCTACTATGCACGACCTTGTTCATACTATTAATGACCAGTCTCAATAT
ATTCATCATTTAGAGGCAGAAGTTAAGTTCTGCAAGAAACTAATGGCAGATCCCGGAAATCCAGACTTGTATCATGTATTAAGTGTTATC
TGGCAATTAGCTTGTGAGATTAAGGTTCTGCACATGGAGCCTTGGTCATCATTTGATATATACACCCGGAAAGGGCCGCTGGAAAACCCA
AAGCGTAGGGAATTATTAGACCAATTACAACAAAAGCTGTATCTTATTCAAATGATTCCTCGTCAAAATTTATTTACCAAGAACTTAACA
CCTATGAACTATAATATATTTTTTCACTTGTTAAAGCACTGTTTTGGGAGGCGCAGCGCCACTGTAATAGACCACTTACGTTCATTGACT
CCACTTGATGCGAGAGATATATTGATGCAAATAGGAAAACAGGAGGATGAGAAAGTAGTTAACATGCACCCTCAAGACTTCAAAACACTT
TTTGAAACTATAGAGCGTTCCAAAGATTGTGCTTATAAATGGCTGTATGATGAAACCCTGGAAGATAGGTAGCAACTAGACTGTCGTTTT
TGGTGGAGCGGTTCATTTATTTGGAAACTATGACATGAAAACCAAATTTGAAAACTCACATCCTTTCAGCAGAAGGTAACTGTTCTTGTC
TTGCACAAGCCAGGCAGATCATTTCTCCTAAGCTGATATCATTGGCTTATTGGATGAAACAGTGTCTGCTATTTTATTCACAATTGAATA
AAATGAAAACTTCAATTAATTGTGGATTTGATCAGATTGAATTCGTTTTGTTTCAGATTCCTATTTAAATATTTCACTTGTACTGTTGCT
GATTTTTGCATCTTCTTGAAGAGCAAGAGTCTGTACATTATTAAGCTTAGAAAGTAAGCAAAACTGATTTACTGGTTTGCCTTTCAGTTT
GTTGAAATGTATTGTCAAGTACTGTACAATGAAATTGTTTAAATTTTAATATGATTTAAGCTTTTTAGAAATTAAAATATTTTAAATAAG

>79855_79855_1_SDCCAG8-TFB2M_SDCCAG8_chr1_243437958_ENST00000355875_TFB2M_chr1_246714604_ENST00000366514_length(amino acids)=301AA_BP=140
MAKSPENSTLEEILGQYQRSLREHASRSIHQLTCALKEGDVTIGEDAPNLSFSTSVGNEDARTAWPELQQSHAVNQLKDLLRQQADKESE
VSPSRRRKMSPLRSLEHEETNMPTMHDLVHTINDQSQYIHHLEAEVKFCKKLMADPGNPDLYHVLSVIWQLACEIKVLHMEPWSSFDIYT
RKGPLENPKRRELLDQLQQKLYLIQMIPRQNLFTKNLTPMNYNIFFHLLKHCFGRRSATVIDHLRSLTPLDARDILMQIGKQEDEKVVNM

--------------------------------------------------------------
>79855_79855_2_SDCCAG8-TFB2M_SDCCAG8_chr1_243437958_ENST00000366541_TFB2M_chr1_246714604_ENST00000366514_length(transcript)=1495nt_BP=538nt
GTGACAGCCGCGGCAGGAAGCAGGCGGGCGCTCCCCGGCCACAGGCCTGTTGTTCTCGGAAGGGAGAAAGCTGGACATTTCCCCACGTAA
CTCCCAGCTCTGGGCCTAGAGTGCGTGCATGGCGAAGTCCCCGGAGAACTCTACCCTGGAGGAGATTCTGGGGCAGTATCAACGGAGTCT
CCGGGAACATGCCAGCAGAAGCATTCACCAACTGACATGTGCCCTGAAAGAAGGCGATGTCACTATTGGAGAAGATGCACCAAATCTTTC
TTTTAGCACCAGTGTGGGAAATGAGGACGCCAGGACAGCCTGGCCCGAATTACAACAGAGCCATGCTGTTAATCAGCTCAAAGATTTGTT
GCGCCAACAAGCAGATAAGGAAAGTGAAGTATCTCCGTCAAGAAGAAGAAAAATGTCCCCCTTGAGGTCATTAGAACATGAGGAAACCAA
TATGCCTACTATGCACGACCTTGTTCATACTATTAATGACCAGTCTCAATATATTCATCATTTAGAGGCAGAAGTTAAGTTCTGCAAGAA
ACTAATGGCAGATCCCGGAAATCCAGACTTGTATCATGTATTAAGTGTTATCTGGCAATTAGCTTGTGAGATTAAGGTTCTGCACATGGA
GCCTTGGTCATCATTTGATATATACACCCGGAAAGGGCCGCTGGAAAACCCAAAGCGTAGGGAATTATTAGACCAATTACAACAAAAGCT
GTATCTTATTCAAATGATTCCTCGTCAAAATTTATTTACCAAGAACTTAACACCTATGAACTATAATATATTTTTTCACTTGTTAAAGCA
CTGTTTTGGGAGGCGCAGCGCCACTGTAATAGACCACTTACGTTCATTGACTCCACTTGATGCGAGAGATATATTGATGCAAATAGGAAA
ACAGGAGGATGAGAAAGTAGTTAACATGCACCCTCAAGACTTCAAAACACTTTTTGAAACTATAGAGCGTTCCAAAGATTGTGCTTATAA
ATGGCTGTATGATGAAACCCTGGAAGATAGGTAGCAACTAGACTGTCGTTTTTGGTGGAGCGGTTCATTTATTTGGAAACTATGACATGA
AAACCAAATTTGAAAACTCACATCCTTTCAGCAGAAGGTAACTGTTCTTGTCTTGCACAAGCCAGGCAGATCATTTCTCCTAAGCTGATA
TCATTGGCTTATTGGATGAAACAGTGTCTGCTATTTTATTCACAATTGAATAAAATGAAAACTTCAATTAATTGTGGATTTGATCAGATT
GAATTCGTTTTGTTTCAGATTCCTATTTAAATATTTCACTTGTACTGTTGCTGATTTTTGCATCTTCTTGAAGAGCAAGAGTCTGTACAT
TATTAAGCTTAGAAAGTAAGCAAAACTGATTTACTGGTTTGCCTTTCAGTTTGTTGAAATGTATTGTCAAGTACTGTACAATGAAATTGT

>79855_79855_2_SDCCAG8-TFB2M_SDCCAG8_chr1_243437958_ENST00000366541_TFB2M_chr1_246714604_ENST00000366514_length(amino acids)=301AA_BP=140
MAKSPENSTLEEILGQYQRSLREHASRSIHQLTCALKEGDVTIGEDAPNLSFSTSVGNEDARTAWPELQQSHAVNQLKDLLRQQADKESE
VSPSRRRKMSPLRSLEHEETNMPTMHDLVHTINDQSQYIHHLEAEVKFCKKLMADPGNPDLYHVLSVIWQLACEIKVLHMEPWSSFDIYT
RKGPLENPKRRELLDQLQQKLYLIQMIPRQNLFTKNLTPMNYNIFFHLLKHCFGRRSATVIDHLRSLTPLDARDILMQIGKQEDEKVVNM

--------------------------------------------------------------
>79855_79855_3_SDCCAG8-TFB2M_SDCCAG8_chr1_243437958_ENST00000391846_TFB2M_chr1_246714604_ENST00000366514_length(transcript)=1533nt_BP=576nt
AGCCCCCAAGAGCTCTGTGCGGGATTCTAGGCTCCCCTGTGACAGCCGCGGCAGGAAGCAGGCGGGCGCTCCCCGGCCACAGGCCTGTTG
TTCTCGGAAGGGAGAAAGCTGGACATTTCCCCACGTAACTCCCAGCTCTGGGCCTAGAGTGCGTGCATGGCGAAGTCCCCGGAGAACTCT
ACCCTGGAGGAGATTCTGGGGCAGTATCAACGGAGTCTCCGGGAACATGCCAGCAGAAGCATTCACCAACTGACATGTGCCCTGAAAGAA
GGCGATGTCACTATTGGAGAAGATGCACCAAATCTTTCTTTTAGCACCAGTGTGGGAAATGAGGACGCCAGGACAGCCTGGCCCGAATTA
CAACAGAGCCATGCTGTTAATCAGCTCAAAGATTTGTTGCGCCAACAAGCAGATAAGGAAAGTGAAGTATCTCCGTCAAGAAGAAGAAAA
ATGTCCCCCTTGAGGTCATTAGAACATGAGGAAACCAATATGCCTACTATGCACGACCTTGTTCATACTATTAATGACCAGTCTCAATAT
ATTCATCATTTAGAGGCAGAAGTTAAGTTCTGCAAGAAACTAATGGCAGATCCCGGAAATCCAGACTTGTATCATGTATTAAGTGTTATC
TGGCAATTAGCTTGTGAGATTAAGGTTCTGCACATGGAGCCTTGGTCATCATTTGATATATACACCCGGAAAGGGCCGCTGGAAAACCCA
AAGCGTAGGGAATTATTAGACCAATTACAACAAAAGCTGTATCTTATTCAAATGATTCCTCGTCAAAATTTATTTACCAAGAACTTAACA
CCTATGAACTATAATATATTTTTTCACTTGTTAAAGCACTGTTTTGGGAGGCGCAGCGCCACTGTAATAGACCACTTACGTTCATTGACT
CCACTTGATGCGAGAGATATATTGATGCAAATAGGAAAACAGGAGGATGAGAAAGTAGTTAACATGCACCCTCAAGACTTCAAAACACTT
TTTGAAACTATAGAGCGTTCCAAAGATTGTGCTTATAAATGGCTGTATGATGAAACCCTGGAAGATAGGTAGCAACTAGACTGTCGTTTT
TGGTGGAGCGGTTCATTTATTTGGAAACTATGACATGAAAACCAAATTTGAAAACTCACATCCTTTCAGCAGAAGGTAACTGTTCTTGTC
TTGCACAAGCCAGGCAGATCATTTCTCCTAAGCTGATATCATTGGCTTATTGGATGAAACAGTGTCTGCTATTTTATTCACAATTGAATA
AAATGAAAACTTCAATTAATTGTGGATTTGATCAGATTGAATTCGTTTTGTTTCAGATTCCTATTTAAATATTTCACTTGTACTGTTGCT
GATTTTTGCATCTTCTTGAAGAGCAAGAGTCTGTACATTATTAAGCTTAGAAAGTAAGCAAAACTGATTTACTGGTTTGCCTTTCAGTTT
GTTGAAATGTATTGTCAAGTACTGTACAATGAAATTGTTTAAATTTTAATATGATTTAAGCTTTTTAGAAATTAAAATATTTTAAATAAG

>79855_79855_3_SDCCAG8-TFB2M_SDCCAG8_chr1_243437958_ENST00000391846_TFB2M_chr1_246714604_ENST00000366514_length(amino acids)=301AA_BP=140
MAKSPENSTLEEILGQYQRSLREHASRSIHQLTCALKEGDVTIGEDAPNLSFSTSVGNEDARTAWPELQQSHAVNQLKDLLRQQADKESE
VSPSRRRKMSPLRSLEHEETNMPTMHDLVHTINDQSQYIHHLEAEVKFCKKLMADPGNPDLYHVLSVIWQLACEIKVLHMEPWSSFDIYT
RKGPLENPKRRELLDQLQQKLYLIQMIPRQNLFTKNLTPMNYNIFFHLLKHCFGRRSATVIDHLRSLTPLDARDILMQIGKQEDEKVVNM

--------------------------------------------------------------

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Fusion Gene PPI Analysis for SDCCAG8-TFB2M


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for SDCCAG8-TFB2M


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for SDCCAG8-TFB2M


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource