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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:SDSL-DTX1 (FusionGDB2 ID:79963)

Fusion Gene Summary for SDSL-DTX1

check button Fusion gene summary
Fusion gene informationFusion gene name: SDSL-DTX1
Fusion gene ID: 79963
HgeneTgene
Gene symbol

SDSL

DTX1

Gene ID

113675

1840

Gene nameserine dehydratase likedeltex E3 ubiquitin ligase 1
SynonymsSDH 2|SDS-RS1|TDH|cSDHRNF140|hDx-1
Cytomap

12q24.13

12q24.13

Type of geneprotein-codingprotein-coding
Descriptionserine dehydratase-likeL-serine deaminaseL-serine dehydratase/L-threonine deaminaseL-threonine dehydrataseserine dehydratase 2serine dehydratase related sequence 1E3 ubiquitin-protein ligase DTX1RING-type E3 ubiquitin transferase DTX1deltex 1, E3 ubiquitin ligasedeltex homolog 1deltex1hDTX1protein deltex-1
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000345635, ENST00000403593, 
ENST00000547974, ENST00000257600, 
Fusion gene scores* DoF score3 X 3 X 3=274 X 3 X 4=48
# samples 45
** MAII scorelog2(4/27*10)=0.567040592723894
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(5/48*10)=0.0588936890535686
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: SDSL [Title/Abstract] AND DTX1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointSDSL(113866264)-DTX1(113515229), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across SDSL (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across DTX1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-VQ-A8E0-01ASDSLchr12

113866264

+DTX1chr12

113515229

+
ChimerDB4STADTCGA-VQ-A8E0SDSLchr12

113866264

+DTX1chr12

113515228

+


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Fusion Gene ORF analysis for SDSL-DTX1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000345635ENST00000547974SDSLchr12

113866264

+DTX1chr12

113515229

+
5CDS-intronENST00000345635ENST00000547974SDSLchr12

113866264

+DTX1chr12

113515228

+
5CDS-intronENST00000403593ENST00000547974SDSLchr12

113866264

+DTX1chr12

113515229

+
5CDS-intronENST00000403593ENST00000547974SDSLchr12

113866264

+DTX1chr12

113515228

+
In-frameENST00000345635ENST00000257600SDSLchr12

113866264

+DTX1chr12

113515229

+
In-frameENST00000345635ENST00000257600SDSLchr12

113866264

+DTX1chr12

113515228

+
In-frameENST00000403593ENST00000257600SDSLchr12

113866264

+DTX1chr12

113515229

+
In-frameENST00000403593ENST00000257600SDSLchr12

113866264

+DTX1chr12

113515228

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000403593SDSLchr12113866264+ENST00000257600DTX1chr12113515229+31694762292079616
ENST00000345635SDSLchr12113866264+ENST00000257600DTX1chr12113515229+31174241772027616
ENST00000403593SDSLchr12113866264+ENST00000257600DTX1chr12113515228+31694762292079616
ENST00000345635SDSLchr12113866264+ENST00000257600DTX1chr12113515228+31174241772027616

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000403593ENST00000257600SDSLchr12113866264+DTX1chr12113515229+0.0572653260.9427347
ENST00000345635ENST00000257600SDSLchr12113866264+DTX1chr12113515229+0.0626458450.93735415
ENST00000403593ENST00000257600SDSLchr12113866264+DTX1chr12113515228+0.0572653260.9427347
ENST00000345635ENST00000257600SDSLchr12113866264+DTX1chr12113515228+0.0626458450.93735415

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Fusion Genomic Features for SDSL-DTX1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
SDSLchr12113866264+DTX1chr12113515228+1.63E-101
SDSLchr12113866264+DTX1chr12113515228+1.63E-101
SDSLchr12113866264+DTX1chr12113515228+1.63E-101
SDSLchr12113866264+DTX1chr12113515228+1.63E-101

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for SDSL-DTX1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:113866264/chr12:113515229)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneDTX1chr12:113866264chr12:113515228ENST0000025760009227_37586621.0Compositional biasNote=Pro-rich
TgeneDTX1chr12:113866264chr12:113515229ENST0000025760009227_37586621.0Compositional biasNote=Pro-rich
TgeneDTX1chr12:113866264chr12:113515228ENST000002576000995_17186621.0DomainWWE 2
TgeneDTX1chr12:113866264chr12:113515229ENST000002576000995_17186621.0DomainWWE 2
TgeneDTX1chr12:113866264chr12:113515228ENST0000025760009230_23386621.0MotifSH3-binding
TgeneDTX1chr12:113866264chr12:113515229ENST0000025760009230_23386621.0MotifSH3-binding
TgeneDTX1chr12:113866264chr12:113515228ENST0000025760009411_47286621.0Zinc fingerRING-type
TgeneDTX1chr12:113866264chr12:113515229ENST0000025760009411_47286621.0Zinc fingerRING-type

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneDTX1chr12:113866264chr12:113515228ENST000002576000914_9486621.0DomainWWE 1
TgeneDTX1chr12:113866264chr12:113515229ENST000002576000914_9486621.0DomainWWE 1


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Fusion Gene Sequence for SDSL-DTX1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>79963_79963_1_SDSL-DTX1_SDSL_chr12_113866264_ENST00000345635_DTX1_chr12_113515228_ENST00000257600_length(transcript)=3117nt_BP=424nt
CTGGTTCCCTGGCAGGCTGGAGGGCAGGAGCTGGGGCCACGCTGGTCTGGGATAGTTGGGCAGGGAGACGGAGTCTCGATCTGTCACCCA
GGCTGGAGTGCAGTGGCACAACCTTGGCTCACTGCAACCTCCGCCTCCCAGGTTCAAGTGATTCTCCTGCCTCAGCCTTCTGAGTAGCTG
GAATTACAAGCTGTCTACCTGGTCTCCAGAATGGACGGCCCTGTGGCAGAGCATGCCAAGCAGGAGCCCTTTCACGTGGTCACACCTCTG
TTGGAGAGCTGGGCGCTGTCCCAGGTGGCGGGCATGCCTGTCTTCCTCAAGTGTGAGAATGTGCAGCCCAGCGGCTCCTTCAAGATTCGG
GGCATTGGGCATTTCTGCCAGGAGATGGCCAAGAAGGGATGCAGACACCTGGTGTGCTCCTCAGGCACCATGCGGCCCGTGCGGCGCAAC
TTCTACGACCCGTCGTCGGCGCCGGGCAAGGGCATCGTGTGGGAGTGGGAGAACGACGGCGGCGCATGGACGGCCTACGATATGGACATC
TGCATCACCATCCAGAACGCCTACGAGAAGCAGCACCCGTGGCTCGACCTCTCATCGCTAGGCTTCTGCTACCTCATCTACTTCAACAGC
ATGTCGCAGATGAACCGCCAGACGCGCCGGCGCCGCCGCCTGCGCCGCCGCCTGGACCTCGCCTACCCGCTCACCGTGGGCTCCATCCCT
AAGTCGCAGTCGTGGCCCGTGGGCGCCAGCTCGGGCCAGCCCTGCTCCTGCCAGCAGTGCCTGCTGGTCAACAGCACGCGCGCCGCCTCC
AACGCCATCCTGGCCTCGCAGCGCCGCAAGGCGCCCCCCGCGCCCCCGCTGCCGCCGCCGCCGCCACCTGGAGGGCCTCCAGGCGCGCTT
GCCGTGCGCCCCAGCGCCACCTTCACAGGCGCCGCGCTCTGGGCAGCGCCCGCCGCCGGCCCCGCCGAGCCCGCGCCGCCTCCCGGGGCG
CCCCCACGGAGCCCGGGCGCCCCCGGCGGAGCGCGCACCCCGGGGCAGAACAACCTCAACCGGCCCGGGCCCCAGCGCACCACCAGCGTG
AGCGCGCGCGCCTCCATCCCGCCGGGGGTCCCCGCACTCCCGGTGAAGAACTTGAATGGTACTGGGCCGGTCCATCCGGCCCTGGCAGGG
ATGACCGGGATACTGCTGTGCGCGGCCGGGCTGCCCGTGTGCCTGACGCGGGCCCCCAAGCCCATCCTGCACCCGCCGCCCGTGAGCAAG
AGCGACGTGAAGCCCGTGCCTGGCGTGCCCGGGGTGTGCCGCAAGACCAAGAAGAAGCACCTTAAAAAGAGTAAGAATCCCGAGGATGTG
GTTCGAAGATACATGCAGAAGGTGAAAAACCCACCTGATGAGGACTGCACCATCTGCATGGAGCGACTGGTCACAGCATCAGGCTACGAG
GGCGTGCTTCGGCACAAGGGCGTGCGGCCTGAGCTCGTGGGCCGCCTGGGCCGCTGTGGCCACATGTACCACCTGCTGTGCCTCGTGGCC
ATGTACTCCAATGGCAACAAGGATGGCAGCCTGCAGTGCCCCACCTGCAAGGCCATCTACGGGGAGAAGACGGGTACGCAGCCGCCTGGG
AAGATGGAGTTCCACCTCATCCCCCACTCGCTGCCCGGCTTCCCTGATACCCAGACCATCCGCATCGTCTATGACATCCCCACAGGCATC
CAGGGCCCTGAGCACCCCAACCCCGGGAAGAAGTTCACCGCAAGAGGATTCCCTCGCCACTGCTATCTACCCAACAACGAGAAAGGCCGG
AAGGTGCTGCGGCTGCTCATCACGGCCTGGGAGAGAAGACTCATCTTCACTATCGGCACGTCCAACACCACGGGCGAGTCGGACACCGTG
GTGTGGAACGAGATCCACCACAAGACCGAGTTTGGATCCAACCTCACGGGCCACGGCTACCCGGACGCTAGCTACCTAGACAACGTGCTG
GCTGAGCTCACAGCCCAGGGCGTATCCGAGGCTGCAGCCAAGGCTTGAGGCCCAAGGCTGCCCACCTTCCCTCCTGCTTTGCCCCTGGTC
CGGCAAATGCCTCCTTCGCCAGGTGTGTCCTGGTAGCCCAGGTTCAGGGCTGGGGAGGAGCCTGCGGAAGGGGCCGCAGCCATTCAGGGG
ACCTGCCTGGTGGCAGCTGGGATGAAGAGAGATGGCATGTCAGGCTGGCCCCGAATCATAGCTCCCTGAGAGGGCCAAGCAGAGAGTACT
GGAAACCTCCCTACCAAAAAGACAGAGACCCGCCCCCTCACACACAAACACACATGTCCTGTTGAACTCATGCACGCACACCCACGTGCC
TGTACTTGCCCCCAGGCTGGAAGAGAAGAGACAGAAAGACCCCATGACCCCCCCATGTGGATCCCCATCTGTGTCTCAGTTGCATCTGTA
CAGCCTTGTCTGCAAACTGGAGGATGCGGGGCAAGCCCTTAGGGGCCTGCCAGGGCTCGGGGGGCAAAGAGGGACTCGGGAAACTCAGTG
TACCCCAGATGCCTCACCCATTCCGTGTCATCACCCATGTCTGCCACCCACTGATTGGGCAATTGTGGGCCCATGGGGTGGAAGCCCCCA
GATGACTGAGCAGTTCTACAAAAGAATGGCCAGCACGAGCGGGGACTAGAGGGTCCTGATTTTGTGTCTGTGCCTCTTCATCTCTCTGGA
CTCTGATCTCCTTCTCCCTTCCCATCTCCAGGCCTTCTGTCTGTCCCAGATAAAGGCGCTGTTCTCCCATCCTCCCTACCCCATCCTCTC
CACCAAATCGCTCCCAATTTTGAGAGCCAAAGGCTGGCGCTTCTGACTTCAGGAGCGAAAGGAGGAGGCCTAGTTTGGGCCGATGTATTT
TAAAGCAGAGTGGACAGCAGAGAGTCAATTTCCCTTTCGTTGGGAGTGGGCAGTGGGGTGGCTAATTGTCTTCGGCCAACCAGGGGCCTG
TTGCCCAGGCAACTCACCAGCTCCGCCTCTGCTGATTGGCTGCCACGGTGGGAGTCAGCCAAGATTTAAAGGGATGCCAGCGATTGCTCT

>79963_79963_1_SDSL-DTX1_SDSL_chr12_113866264_ENST00000345635_DTX1_chr12_113515228_ENST00000257600_length(amino acids)=616AA_BP=22
MELQAVYLVSRMDGPVAEHAKQEPFHVVTPLLESWALSQVAGMPVFLKCENVQPSGSFKIRGIGHFCQEMAKKGCRHLVCSSGTMRPVRR
NFYDPSSAPGKGIVWEWENDGGAWTAYDMDICITIQNAYEKQHPWLDLSSLGFCYLIYFNSMSQMNRQTRRRRRLRRRLDLAYPLTVGSI
PKSQSWPVGASSGQPCSCQQCLLVNSTRAASNAILASQRRKAPPAPPLPPPPPPGGPPGALAVRPSATFTGAALWAAPAAGPAEPAPPPG
APPRSPGAPGGARTPGQNNLNRPGPQRTTSVSARASIPPGVPALPVKNLNGTGPVHPALAGMTGILLCAAGLPVCLTRAPKPILHPPPVS
KSDVKPVPGVPGVCRKTKKKHLKKSKNPEDVVRRYMQKVKNPPDEDCTICMERLVTASGYEGVLRHKGVRPELVGRLGRCGHMYHLLCLV
AMYSNGNKDGSLQCPTCKAIYGEKTGTQPPGKMEFHLIPHSLPGFPDTQTIRIVYDIPTGIQGPEHPNPGKKFTARGFPRHCYLPNNEKG

--------------------------------------------------------------
>79963_79963_2_SDSL-DTX1_SDSL_chr12_113866264_ENST00000345635_DTX1_chr12_113515229_ENST00000257600_length(transcript)=3117nt_BP=424nt
CTGGTTCCCTGGCAGGCTGGAGGGCAGGAGCTGGGGCCACGCTGGTCTGGGATAGTTGGGCAGGGAGACGGAGTCTCGATCTGTCACCCA
GGCTGGAGTGCAGTGGCACAACCTTGGCTCACTGCAACCTCCGCCTCCCAGGTTCAAGTGATTCTCCTGCCTCAGCCTTCTGAGTAGCTG
GAATTACAAGCTGTCTACCTGGTCTCCAGAATGGACGGCCCTGTGGCAGAGCATGCCAAGCAGGAGCCCTTTCACGTGGTCACACCTCTG
TTGGAGAGCTGGGCGCTGTCCCAGGTGGCGGGCATGCCTGTCTTCCTCAAGTGTGAGAATGTGCAGCCCAGCGGCTCCTTCAAGATTCGG
GGCATTGGGCATTTCTGCCAGGAGATGGCCAAGAAGGGATGCAGACACCTGGTGTGCTCCTCAGGCACCATGCGGCCCGTGCGGCGCAAC
TTCTACGACCCGTCGTCGGCGCCGGGCAAGGGCATCGTGTGGGAGTGGGAGAACGACGGCGGCGCATGGACGGCCTACGATATGGACATC
TGCATCACCATCCAGAACGCCTACGAGAAGCAGCACCCGTGGCTCGACCTCTCATCGCTAGGCTTCTGCTACCTCATCTACTTCAACAGC
ATGTCGCAGATGAACCGCCAGACGCGCCGGCGCCGCCGCCTGCGCCGCCGCCTGGACCTCGCCTACCCGCTCACCGTGGGCTCCATCCCT
AAGTCGCAGTCGTGGCCCGTGGGCGCCAGCTCGGGCCAGCCCTGCTCCTGCCAGCAGTGCCTGCTGGTCAACAGCACGCGCGCCGCCTCC
AACGCCATCCTGGCCTCGCAGCGCCGCAAGGCGCCCCCCGCGCCCCCGCTGCCGCCGCCGCCGCCACCTGGAGGGCCTCCAGGCGCGCTT
GCCGTGCGCCCCAGCGCCACCTTCACAGGCGCCGCGCTCTGGGCAGCGCCCGCCGCCGGCCCCGCCGAGCCCGCGCCGCCTCCCGGGGCG
CCCCCACGGAGCCCGGGCGCCCCCGGCGGAGCGCGCACCCCGGGGCAGAACAACCTCAACCGGCCCGGGCCCCAGCGCACCACCAGCGTG
AGCGCGCGCGCCTCCATCCCGCCGGGGGTCCCCGCACTCCCGGTGAAGAACTTGAATGGTACTGGGCCGGTCCATCCGGCCCTGGCAGGG
ATGACCGGGATACTGCTGTGCGCGGCCGGGCTGCCCGTGTGCCTGACGCGGGCCCCCAAGCCCATCCTGCACCCGCCGCCCGTGAGCAAG
AGCGACGTGAAGCCCGTGCCTGGCGTGCCCGGGGTGTGCCGCAAGACCAAGAAGAAGCACCTTAAAAAGAGTAAGAATCCCGAGGATGTG
GTTCGAAGATACATGCAGAAGGTGAAAAACCCACCTGATGAGGACTGCACCATCTGCATGGAGCGACTGGTCACAGCATCAGGCTACGAG
GGCGTGCTTCGGCACAAGGGCGTGCGGCCTGAGCTCGTGGGCCGCCTGGGCCGCTGTGGCCACATGTACCACCTGCTGTGCCTCGTGGCC
ATGTACTCCAATGGCAACAAGGATGGCAGCCTGCAGTGCCCCACCTGCAAGGCCATCTACGGGGAGAAGACGGGTACGCAGCCGCCTGGG
AAGATGGAGTTCCACCTCATCCCCCACTCGCTGCCCGGCTTCCCTGATACCCAGACCATCCGCATCGTCTATGACATCCCCACAGGCATC
CAGGGCCCTGAGCACCCCAACCCCGGGAAGAAGTTCACCGCAAGAGGATTCCCTCGCCACTGCTATCTACCCAACAACGAGAAAGGCCGG
AAGGTGCTGCGGCTGCTCATCACGGCCTGGGAGAGAAGACTCATCTTCACTATCGGCACGTCCAACACCACGGGCGAGTCGGACACCGTG
GTGTGGAACGAGATCCACCACAAGACCGAGTTTGGATCCAACCTCACGGGCCACGGCTACCCGGACGCTAGCTACCTAGACAACGTGCTG
GCTGAGCTCACAGCCCAGGGCGTATCCGAGGCTGCAGCCAAGGCTTGAGGCCCAAGGCTGCCCACCTTCCCTCCTGCTTTGCCCCTGGTC
CGGCAAATGCCTCCTTCGCCAGGTGTGTCCTGGTAGCCCAGGTTCAGGGCTGGGGAGGAGCCTGCGGAAGGGGCCGCAGCCATTCAGGGG
ACCTGCCTGGTGGCAGCTGGGATGAAGAGAGATGGCATGTCAGGCTGGCCCCGAATCATAGCTCCCTGAGAGGGCCAAGCAGAGAGTACT
GGAAACCTCCCTACCAAAAAGACAGAGACCCGCCCCCTCACACACAAACACACATGTCCTGTTGAACTCATGCACGCACACCCACGTGCC
TGTACTTGCCCCCAGGCTGGAAGAGAAGAGACAGAAAGACCCCATGACCCCCCCATGTGGATCCCCATCTGTGTCTCAGTTGCATCTGTA
CAGCCTTGTCTGCAAACTGGAGGATGCGGGGCAAGCCCTTAGGGGCCTGCCAGGGCTCGGGGGGCAAAGAGGGACTCGGGAAACTCAGTG
TACCCCAGATGCCTCACCCATTCCGTGTCATCACCCATGTCTGCCACCCACTGATTGGGCAATTGTGGGCCCATGGGGTGGAAGCCCCCA
GATGACTGAGCAGTTCTACAAAAGAATGGCCAGCACGAGCGGGGACTAGAGGGTCCTGATTTTGTGTCTGTGCCTCTTCATCTCTCTGGA
CTCTGATCTCCTTCTCCCTTCCCATCTCCAGGCCTTCTGTCTGTCCCAGATAAAGGCGCTGTTCTCCCATCCTCCCTACCCCATCCTCTC
CACCAAATCGCTCCCAATTTTGAGAGCCAAAGGCTGGCGCTTCTGACTTCAGGAGCGAAAGGAGGAGGCCTAGTTTGGGCCGATGTATTT
TAAAGCAGAGTGGACAGCAGAGAGTCAATTTCCCTTTCGTTGGGAGTGGGCAGTGGGGTGGCTAATTGTCTTCGGCCAACCAGGGGCCTG
TTGCCCAGGCAACTCACCAGCTCCGCCTCTGCTGATTGGCTGCCACGGTGGGAGTCAGCCAAGATTTAAAGGGATGCCAGCGATTGCTCT

>79963_79963_2_SDSL-DTX1_SDSL_chr12_113866264_ENST00000345635_DTX1_chr12_113515229_ENST00000257600_length(amino acids)=616AA_BP=22
MELQAVYLVSRMDGPVAEHAKQEPFHVVTPLLESWALSQVAGMPVFLKCENVQPSGSFKIRGIGHFCQEMAKKGCRHLVCSSGTMRPVRR
NFYDPSSAPGKGIVWEWENDGGAWTAYDMDICITIQNAYEKQHPWLDLSSLGFCYLIYFNSMSQMNRQTRRRRRLRRRLDLAYPLTVGSI
PKSQSWPVGASSGQPCSCQQCLLVNSTRAASNAILASQRRKAPPAPPLPPPPPPGGPPGALAVRPSATFTGAALWAAPAAGPAEPAPPPG
APPRSPGAPGGARTPGQNNLNRPGPQRTTSVSARASIPPGVPALPVKNLNGTGPVHPALAGMTGILLCAAGLPVCLTRAPKPILHPPPVS
KSDVKPVPGVPGVCRKTKKKHLKKSKNPEDVVRRYMQKVKNPPDEDCTICMERLVTASGYEGVLRHKGVRPELVGRLGRCGHMYHLLCLV
AMYSNGNKDGSLQCPTCKAIYGEKTGTQPPGKMEFHLIPHSLPGFPDTQTIRIVYDIPTGIQGPEHPNPGKKFTARGFPRHCYLPNNEKG

--------------------------------------------------------------
>79963_79963_3_SDSL-DTX1_SDSL_chr12_113866264_ENST00000403593_DTX1_chr12_113515228_ENST00000257600_length(transcript)=3169nt_BP=476nt
GGTGCATGAGTCATAGGCAGTGCCCGGGAAAGCGGTGAGGGTTGCTCTCATCCCCTCTCCTCCTCCGTCTTCACCCGGAGGCTTAGGGTC
TGGAGCTTTCTCTTTAACAAAGGAGGAGGGACCAAGGTTGCCGGAAGCTGCCTGAAGCTGGACAGAGCCGGTTCCTGGAAAGAGCTGGTT
CCCTGGCAGGCTGGAGGGCAGGAGCTGGGGCCACGCTGGTCTGGGATAGTTGGGCAGGGAGGCTGTCTACCTGGTCTCCAGAATGGACGG
CCCTGTGGCAGAGCATGCCAAGCAGGAGCCCTTTCACGTGGTCACACCTCTGTTGGAGAGCTGGGCGCTGTCCCAGGTGGCGGGCATGCC
TGTCTTCCTCAAGTGTGAGAATGTGCAGCCCAGCGGCTCCTTCAAGATTCGGGGCATTGGGCATTTCTGCCAGGAGATGGCCAAGAAGGG
ATGCAGACACCTGGTGTGCTCCTCAGGCACCATGCGGCCCGTGCGGCGCAACTTCTACGACCCGTCGTCGGCGCCGGGCAAGGGCATCGT
GTGGGAGTGGGAGAACGACGGCGGCGCATGGACGGCCTACGATATGGACATCTGCATCACCATCCAGAACGCCTACGAGAAGCAGCACCC
GTGGCTCGACCTCTCATCGCTAGGCTTCTGCTACCTCATCTACTTCAACAGCATGTCGCAGATGAACCGCCAGACGCGCCGGCGCCGCCG
CCTGCGCCGCCGCCTGGACCTCGCCTACCCGCTCACCGTGGGCTCCATCCCTAAGTCGCAGTCGTGGCCCGTGGGCGCCAGCTCGGGCCA
GCCCTGCTCCTGCCAGCAGTGCCTGCTGGTCAACAGCACGCGCGCCGCCTCCAACGCCATCCTGGCCTCGCAGCGCCGCAAGGCGCCCCC
CGCGCCCCCGCTGCCGCCGCCGCCGCCACCTGGAGGGCCTCCAGGCGCGCTTGCCGTGCGCCCCAGCGCCACCTTCACAGGCGCCGCGCT
CTGGGCAGCGCCCGCCGCCGGCCCCGCCGAGCCCGCGCCGCCTCCCGGGGCGCCCCCACGGAGCCCGGGCGCCCCCGGCGGAGCGCGCAC
CCCGGGGCAGAACAACCTCAACCGGCCCGGGCCCCAGCGCACCACCAGCGTGAGCGCGCGCGCCTCCATCCCGCCGGGGGTCCCCGCACT
CCCGGTGAAGAACTTGAATGGTACTGGGCCGGTCCATCCGGCCCTGGCAGGGATGACCGGGATACTGCTGTGCGCGGCCGGGCTGCCCGT
GTGCCTGACGCGGGCCCCCAAGCCCATCCTGCACCCGCCGCCCGTGAGCAAGAGCGACGTGAAGCCCGTGCCTGGCGTGCCCGGGGTGTG
CCGCAAGACCAAGAAGAAGCACCTTAAAAAGAGTAAGAATCCCGAGGATGTGGTTCGAAGATACATGCAGAAGGTGAAAAACCCACCTGA
TGAGGACTGCACCATCTGCATGGAGCGACTGGTCACAGCATCAGGCTACGAGGGCGTGCTTCGGCACAAGGGCGTGCGGCCTGAGCTCGT
GGGCCGCCTGGGCCGCTGTGGCCACATGTACCACCTGCTGTGCCTCGTGGCCATGTACTCCAATGGCAACAAGGATGGCAGCCTGCAGTG
CCCCACCTGCAAGGCCATCTACGGGGAGAAGACGGGTACGCAGCCGCCTGGGAAGATGGAGTTCCACCTCATCCCCCACTCGCTGCCCGG
CTTCCCTGATACCCAGACCATCCGCATCGTCTATGACATCCCCACAGGCATCCAGGGCCCTGAGCACCCCAACCCCGGGAAGAAGTTCAC
CGCAAGAGGATTCCCTCGCCACTGCTATCTACCCAACAACGAGAAAGGCCGGAAGGTGCTGCGGCTGCTCATCACGGCCTGGGAGAGAAG
ACTCATCTTCACTATCGGCACGTCCAACACCACGGGCGAGTCGGACACCGTGGTGTGGAACGAGATCCACCACAAGACCGAGTTTGGATC
CAACCTCACGGGCCACGGCTACCCGGACGCTAGCTACCTAGACAACGTGCTGGCTGAGCTCACAGCCCAGGGCGTATCCGAGGCTGCAGC
CAAGGCTTGAGGCCCAAGGCTGCCCACCTTCCCTCCTGCTTTGCCCCTGGTCCGGCAAATGCCTCCTTCGCCAGGTGTGTCCTGGTAGCC
CAGGTTCAGGGCTGGGGAGGAGCCTGCGGAAGGGGCCGCAGCCATTCAGGGGACCTGCCTGGTGGCAGCTGGGATGAAGAGAGATGGCAT
GTCAGGCTGGCCCCGAATCATAGCTCCCTGAGAGGGCCAAGCAGAGAGTACTGGAAACCTCCCTACCAAAAAGACAGAGACCCGCCCCCT
CACACACAAACACACATGTCCTGTTGAACTCATGCACGCACACCCACGTGCCTGTACTTGCCCCCAGGCTGGAAGAGAAGAGACAGAAAG
ACCCCATGACCCCCCCATGTGGATCCCCATCTGTGTCTCAGTTGCATCTGTACAGCCTTGTCTGCAAACTGGAGGATGCGGGGCAAGCCC
TTAGGGGCCTGCCAGGGCTCGGGGGGCAAAGAGGGACTCGGGAAACTCAGTGTACCCCAGATGCCTCACCCATTCCGTGTCATCACCCAT
GTCTGCCACCCACTGATTGGGCAATTGTGGGCCCATGGGGTGGAAGCCCCCAGATGACTGAGCAGTTCTACAAAAGAATGGCCAGCACGA
GCGGGGACTAGAGGGTCCTGATTTTGTGTCTGTGCCTCTTCATCTCTCTGGACTCTGATCTCCTTCTCCCTTCCCATCTCCAGGCCTTCT
GTCTGTCCCAGATAAAGGCGCTGTTCTCCCATCCTCCCTACCCCATCCTCTCCACCAAATCGCTCCCAATTTTGAGAGCCAAAGGCTGGC
GCTTCTGACTTCAGGAGCGAAAGGAGGAGGCCTAGTTTGGGCCGATGTATTTTAAAGCAGAGTGGACAGCAGAGAGTCAATTTCCCTTTC
GTTGGGAGTGGGCAGTGGGGTGGCTAATTGTCTTCGGCCAACCAGGGGCCTGTTGCCCAGGCAACTCACCAGCTCCGCCTCTGCTGATTG
GCTGCCACGGTGGGAGTCAGCCAAGATTTAAAGGGATGCCAGCGATTGCTCTTTTCAAAACCTACCAGTCCCACTGTGGGTGGAGAAATA

>79963_79963_3_SDSL-DTX1_SDSL_chr12_113866264_ENST00000403593_DTX1_chr12_113515228_ENST00000257600_length(amino acids)=616AA_BP=22
MGREAVYLVSRMDGPVAEHAKQEPFHVVTPLLESWALSQVAGMPVFLKCENVQPSGSFKIRGIGHFCQEMAKKGCRHLVCSSGTMRPVRR
NFYDPSSAPGKGIVWEWENDGGAWTAYDMDICITIQNAYEKQHPWLDLSSLGFCYLIYFNSMSQMNRQTRRRRRLRRRLDLAYPLTVGSI
PKSQSWPVGASSGQPCSCQQCLLVNSTRAASNAILASQRRKAPPAPPLPPPPPPGGPPGALAVRPSATFTGAALWAAPAAGPAEPAPPPG
APPRSPGAPGGARTPGQNNLNRPGPQRTTSVSARASIPPGVPALPVKNLNGTGPVHPALAGMTGILLCAAGLPVCLTRAPKPILHPPPVS
KSDVKPVPGVPGVCRKTKKKHLKKSKNPEDVVRRYMQKVKNPPDEDCTICMERLVTASGYEGVLRHKGVRPELVGRLGRCGHMYHLLCLV
AMYSNGNKDGSLQCPTCKAIYGEKTGTQPPGKMEFHLIPHSLPGFPDTQTIRIVYDIPTGIQGPEHPNPGKKFTARGFPRHCYLPNNEKG

--------------------------------------------------------------
>79963_79963_4_SDSL-DTX1_SDSL_chr12_113866264_ENST00000403593_DTX1_chr12_113515229_ENST00000257600_length(transcript)=3169nt_BP=476nt
GGTGCATGAGTCATAGGCAGTGCCCGGGAAAGCGGTGAGGGTTGCTCTCATCCCCTCTCCTCCTCCGTCTTCACCCGGAGGCTTAGGGTC
TGGAGCTTTCTCTTTAACAAAGGAGGAGGGACCAAGGTTGCCGGAAGCTGCCTGAAGCTGGACAGAGCCGGTTCCTGGAAAGAGCTGGTT
CCCTGGCAGGCTGGAGGGCAGGAGCTGGGGCCACGCTGGTCTGGGATAGTTGGGCAGGGAGGCTGTCTACCTGGTCTCCAGAATGGACGG
CCCTGTGGCAGAGCATGCCAAGCAGGAGCCCTTTCACGTGGTCACACCTCTGTTGGAGAGCTGGGCGCTGTCCCAGGTGGCGGGCATGCC
TGTCTTCCTCAAGTGTGAGAATGTGCAGCCCAGCGGCTCCTTCAAGATTCGGGGCATTGGGCATTTCTGCCAGGAGATGGCCAAGAAGGG
ATGCAGACACCTGGTGTGCTCCTCAGGCACCATGCGGCCCGTGCGGCGCAACTTCTACGACCCGTCGTCGGCGCCGGGCAAGGGCATCGT
GTGGGAGTGGGAGAACGACGGCGGCGCATGGACGGCCTACGATATGGACATCTGCATCACCATCCAGAACGCCTACGAGAAGCAGCACCC
GTGGCTCGACCTCTCATCGCTAGGCTTCTGCTACCTCATCTACTTCAACAGCATGTCGCAGATGAACCGCCAGACGCGCCGGCGCCGCCG
CCTGCGCCGCCGCCTGGACCTCGCCTACCCGCTCACCGTGGGCTCCATCCCTAAGTCGCAGTCGTGGCCCGTGGGCGCCAGCTCGGGCCA
GCCCTGCTCCTGCCAGCAGTGCCTGCTGGTCAACAGCACGCGCGCCGCCTCCAACGCCATCCTGGCCTCGCAGCGCCGCAAGGCGCCCCC
CGCGCCCCCGCTGCCGCCGCCGCCGCCACCTGGAGGGCCTCCAGGCGCGCTTGCCGTGCGCCCCAGCGCCACCTTCACAGGCGCCGCGCT
CTGGGCAGCGCCCGCCGCCGGCCCCGCCGAGCCCGCGCCGCCTCCCGGGGCGCCCCCACGGAGCCCGGGCGCCCCCGGCGGAGCGCGCAC
CCCGGGGCAGAACAACCTCAACCGGCCCGGGCCCCAGCGCACCACCAGCGTGAGCGCGCGCGCCTCCATCCCGCCGGGGGTCCCCGCACT
CCCGGTGAAGAACTTGAATGGTACTGGGCCGGTCCATCCGGCCCTGGCAGGGATGACCGGGATACTGCTGTGCGCGGCCGGGCTGCCCGT
GTGCCTGACGCGGGCCCCCAAGCCCATCCTGCACCCGCCGCCCGTGAGCAAGAGCGACGTGAAGCCCGTGCCTGGCGTGCCCGGGGTGTG
CCGCAAGACCAAGAAGAAGCACCTTAAAAAGAGTAAGAATCCCGAGGATGTGGTTCGAAGATACATGCAGAAGGTGAAAAACCCACCTGA
TGAGGACTGCACCATCTGCATGGAGCGACTGGTCACAGCATCAGGCTACGAGGGCGTGCTTCGGCACAAGGGCGTGCGGCCTGAGCTCGT
GGGCCGCCTGGGCCGCTGTGGCCACATGTACCACCTGCTGTGCCTCGTGGCCATGTACTCCAATGGCAACAAGGATGGCAGCCTGCAGTG
CCCCACCTGCAAGGCCATCTACGGGGAGAAGACGGGTACGCAGCCGCCTGGGAAGATGGAGTTCCACCTCATCCCCCACTCGCTGCCCGG
CTTCCCTGATACCCAGACCATCCGCATCGTCTATGACATCCCCACAGGCATCCAGGGCCCTGAGCACCCCAACCCCGGGAAGAAGTTCAC
CGCAAGAGGATTCCCTCGCCACTGCTATCTACCCAACAACGAGAAAGGCCGGAAGGTGCTGCGGCTGCTCATCACGGCCTGGGAGAGAAG
ACTCATCTTCACTATCGGCACGTCCAACACCACGGGCGAGTCGGACACCGTGGTGTGGAACGAGATCCACCACAAGACCGAGTTTGGATC
CAACCTCACGGGCCACGGCTACCCGGACGCTAGCTACCTAGACAACGTGCTGGCTGAGCTCACAGCCCAGGGCGTATCCGAGGCTGCAGC
CAAGGCTTGAGGCCCAAGGCTGCCCACCTTCCCTCCTGCTTTGCCCCTGGTCCGGCAAATGCCTCCTTCGCCAGGTGTGTCCTGGTAGCC
CAGGTTCAGGGCTGGGGAGGAGCCTGCGGAAGGGGCCGCAGCCATTCAGGGGACCTGCCTGGTGGCAGCTGGGATGAAGAGAGATGGCAT
GTCAGGCTGGCCCCGAATCATAGCTCCCTGAGAGGGCCAAGCAGAGAGTACTGGAAACCTCCCTACCAAAAAGACAGAGACCCGCCCCCT
CACACACAAACACACATGTCCTGTTGAACTCATGCACGCACACCCACGTGCCTGTACTTGCCCCCAGGCTGGAAGAGAAGAGACAGAAAG
ACCCCATGACCCCCCCATGTGGATCCCCATCTGTGTCTCAGTTGCATCTGTACAGCCTTGTCTGCAAACTGGAGGATGCGGGGCAAGCCC
TTAGGGGCCTGCCAGGGCTCGGGGGGCAAAGAGGGACTCGGGAAACTCAGTGTACCCCAGATGCCTCACCCATTCCGTGTCATCACCCAT
GTCTGCCACCCACTGATTGGGCAATTGTGGGCCCATGGGGTGGAAGCCCCCAGATGACTGAGCAGTTCTACAAAAGAATGGCCAGCACGA
GCGGGGACTAGAGGGTCCTGATTTTGTGTCTGTGCCTCTTCATCTCTCTGGACTCTGATCTCCTTCTCCCTTCCCATCTCCAGGCCTTCT
GTCTGTCCCAGATAAAGGCGCTGTTCTCCCATCCTCCCTACCCCATCCTCTCCACCAAATCGCTCCCAATTTTGAGAGCCAAAGGCTGGC
GCTTCTGACTTCAGGAGCGAAAGGAGGAGGCCTAGTTTGGGCCGATGTATTTTAAAGCAGAGTGGACAGCAGAGAGTCAATTTCCCTTTC
GTTGGGAGTGGGCAGTGGGGTGGCTAATTGTCTTCGGCCAACCAGGGGCCTGTTGCCCAGGCAACTCACCAGCTCCGCCTCTGCTGATTG
GCTGCCACGGTGGGAGTCAGCCAAGATTTAAAGGGATGCCAGCGATTGCTCTTTTCAAAACCTACCAGTCCCACTGTGGGTGGAGAAATA

>79963_79963_4_SDSL-DTX1_SDSL_chr12_113866264_ENST00000403593_DTX1_chr12_113515229_ENST00000257600_length(amino acids)=616AA_BP=22
MGREAVYLVSRMDGPVAEHAKQEPFHVVTPLLESWALSQVAGMPVFLKCENVQPSGSFKIRGIGHFCQEMAKKGCRHLVCSSGTMRPVRR
NFYDPSSAPGKGIVWEWENDGGAWTAYDMDICITIQNAYEKQHPWLDLSSLGFCYLIYFNSMSQMNRQTRRRRRLRRRLDLAYPLTVGSI
PKSQSWPVGASSGQPCSCQQCLLVNSTRAASNAILASQRRKAPPAPPLPPPPPPGGPPGALAVRPSATFTGAALWAAPAAGPAEPAPPPG
APPRSPGAPGGARTPGQNNLNRPGPQRTTSVSARASIPPGVPALPVKNLNGTGPVHPALAGMTGILLCAAGLPVCLTRAPKPILHPPPVS
KSDVKPVPGVPGVCRKTKKKHLKKSKNPEDVVRRYMQKVKNPPDEDCTICMERLVTASGYEGVLRHKGVRPELVGRLGRCGHMYHLLCLV
AMYSNGNKDGSLQCPTCKAIYGEKTGTQPPGKMEFHLIPHSLPGFPDTQTIRIVYDIPTGIQGPEHPNPGKKFTARGFPRHCYLPNNEKG

--------------------------------------------------------------

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Fusion Gene PPI Analysis for SDSL-DTX1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for SDSL-DTX1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for SDSL-DTX1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource