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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:SEC13-GOLPH3L (FusionGDB2 ID:79977)

Fusion Gene Summary for SEC13-GOLPH3L

check button Fusion gene summary
Fusion gene informationFusion gene name: SEC13-GOLPH3L
Fusion gene ID: 79977
HgeneTgene
Gene symbol

SEC13

GOLPH3L

Gene ID

6396

55204

Gene nameSEC13 homolog, nuclear pore and COPII coat complex componentgolgi phosphoprotein 3 like
SynonymsD3S1231E|SEC13L1|SEC13R|npp-20GPP34R
Cytomap

3p25.3

1q21.3

Type of geneprotein-codingprotein-coding
Descriptionprotein SEC13 homologGATOR complex protein SEC13SEC13 homolog, nuclear pore and COPII coating complex componentSEC13-like 1 isoformSEC13-like protein 1SEC13-related proteinGolgi phosphoprotein 3-likeGPP34-related protein
Modification date2020032020200313
UniProtAcc.

Q9H4A5

Ensembl transtripts involved in fusion geneENST00000350697, ENST00000337354, 
ENST00000383801, ENST00000397109, 
ENST00000397117, ENST00000492602, 
ENST00000479757, ENST00000271732, 
ENST00000540514, 
Fusion gene scores* DoF score2 X 3 X 2=128 X 5 X 7=280
# samples 310
** MAII scorelog2(3/12*10)=1.32192809488736
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(10/280*10)=-1.48542682717024
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SEC13 [Title/Abstract] AND GOLPH3L [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointSEC13(10362734)-GOLPH3L(150634404), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneSEC13

GO:0090110

cargo loading into COPII-coated vesicle

17499046|18843296


check buttonFusion gene breakpoints across SEC13 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across GOLPH3L (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BLCATCGA-ZF-AA4T-01ASEC13chr3

10362734

-GOLPH3Lchr1

150634404

-
ChimerDB4BLCATCGA-ZF-AA4TSEC13chr3

10362733

-GOLPH3Lchr1

150634404

-


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Fusion Gene ORF analysis for SEC13-GOLPH3L

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000350697ENST00000479757SEC13chr3

10362734

-GOLPH3Lchr1

150634404

-
5CDS-intronENST00000350697ENST00000479757SEC13chr3

10362733

-GOLPH3Lchr1

150634404

-
5UTR-3CDSENST00000337354ENST00000271732SEC13chr3

10362734

-GOLPH3Lchr1

150634404

-
5UTR-3CDSENST00000337354ENST00000271732SEC13chr3

10362733

-GOLPH3Lchr1

150634404

-
5UTR-3CDSENST00000337354ENST00000540514SEC13chr3

10362734

-GOLPH3Lchr1

150634404

-
5UTR-3CDSENST00000337354ENST00000540514SEC13chr3

10362733

-GOLPH3Lchr1

150634404

-
5UTR-3CDSENST00000383801ENST00000271732SEC13chr3

10362734

-GOLPH3Lchr1

150634404

-
5UTR-3CDSENST00000383801ENST00000271732SEC13chr3

10362733

-GOLPH3Lchr1

150634404

-
5UTR-3CDSENST00000383801ENST00000540514SEC13chr3

10362734

-GOLPH3Lchr1

150634404

-
5UTR-3CDSENST00000383801ENST00000540514SEC13chr3

10362733

-GOLPH3Lchr1

150634404

-
5UTR-intronENST00000337354ENST00000479757SEC13chr3

10362734

-GOLPH3Lchr1

150634404

-
5UTR-intronENST00000337354ENST00000479757SEC13chr3

10362733

-GOLPH3Lchr1

150634404

-
5UTR-intronENST00000383801ENST00000479757SEC13chr3

10362734

-GOLPH3Lchr1

150634404

-
5UTR-intronENST00000383801ENST00000479757SEC13chr3

10362733

-GOLPH3Lchr1

150634404

-
In-frameENST00000350697ENST00000271732SEC13chr3

10362734

-GOLPH3Lchr1

150634404

-
In-frameENST00000350697ENST00000271732SEC13chr3

10362733

-GOLPH3Lchr1

150634404

-
In-frameENST00000350697ENST00000540514SEC13chr3

10362734

-GOLPH3Lchr1

150634404

-
In-frameENST00000350697ENST00000540514SEC13chr3

10362733

-GOLPH3Lchr1

150634404

-
intron-3CDSENST00000397109ENST00000271732SEC13chr3

10362734

-GOLPH3Lchr1

150634404

-
intron-3CDSENST00000397109ENST00000271732SEC13chr3

10362733

-GOLPH3Lchr1

150634404

-
intron-3CDSENST00000397109ENST00000540514SEC13chr3

10362734

-GOLPH3Lchr1

150634404

-
intron-3CDSENST00000397109ENST00000540514SEC13chr3

10362733

-GOLPH3Lchr1

150634404

-
intron-3CDSENST00000397117ENST00000271732SEC13chr3

10362734

-GOLPH3Lchr1

150634404

-
intron-3CDSENST00000397117ENST00000271732SEC13chr3

10362733

-GOLPH3Lchr1

150634404

-
intron-3CDSENST00000397117ENST00000540514SEC13chr3

10362734

-GOLPH3Lchr1

150634404

-
intron-3CDSENST00000397117ENST00000540514SEC13chr3

10362733

-GOLPH3Lchr1

150634404

-
intron-3CDSENST00000492602ENST00000271732SEC13chr3

10362734

-GOLPH3Lchr1

150634404

-
intron-3CDSENST00000492602ENST00000271732SEC13chr3

10362733

-GOLPH3Lchr1

150634404

-
intron-3CDSENST00000492602ENST00000540514SEC13chr3

10362734

-GOLPH3Lchr1

150634404

-
intron-3CDSENST00000492602ENST00000540514SEC13chr3

10362733

-GOLPH3Lchr1

150634404

-
intron-intronENST00000397109ENST00000479757SEC13chr3

10362734

-GOLPH3Lchr1

150634404

-
intron-intronENST00000397109ENST00000479757SEC13chr3

10362733

-GOLPH3Lchr1

150634404

-
intron-intronENST00000397117ENST00000479757SEC13chr3

10362734

-GOLPH3Lchr1

150634404

-
intron-intronENST00000397117ENST00000479757SEC13chr3

10362733

-GOLPH3Lchr1

150634404

-
intron-intronENST00000492602ENST00000479757SEC13chr3

10362734

-GOLPH3Lchr1

150634404

-
intron-intronENST00000492602ENST00000479757SEC13chr3

10362733

-GOLPH3Lchr1

150634404

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000350697SEC13chr310362734-ENST00000271732GOLPH3Lchr1150634404-276812987671194
ENST00000350697SEC13chr310362734-ENST00000540514GOLPH3Lchr1150634404-78212987671194
ENST00000350697SEC13chr310362733-ENST00000271732GOLPH3Lchr1150634404-276812987671194
ENST00000350697SEC13chr310362733-ENST00000540514GOLPH3Lchr1150634404-78212987671194

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000350697ENST00000271732SEC13chr310362734-GOLPH3Lchr1150634404-0.0041385810.9958615
ENST00000350697ENST00000540514SEC13chr310362734-GOLPH3Lchr1150634404-0.0059550420.99404496
ENST00000350697ENST00000271732SEC13chr310362733-GOLPH3Lchr1150634404-0.0041385810.9958615
ENST00000350697ENST00000540514SEC13chr310362733-GOLPH3Lchr1150634404-0.0059550420.99404496

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Fusion Genomic Features for SEC13-GOLPH3L


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for SEC13-GOLPH3L


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:10362734/chr1:150634404)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.GOLPH3L

Q9H4A5

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Phosphatidylinositol-4-phosphate-binding protein that may antagonize the action of GOLPH3 which is required for the process of vesicle budding at the Golgi and anterograde transport to the plasma membrane. {ECO:0000269|PubMed:23345592}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneGOLPH3Lchr3:10362733chr1:150634404ENST0000027173225176_187105286.0RegionBeta-hairpin required for oligomerization
TgeneGOLPH3Lchr3:10362734chr1:150634404ENST0000027173225176_187105286.0RegionBeta-hairpin required for oligomerization

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSEC13chr3:10362733chr1:150634404ENST00000337354-110101_1440326.0RepeatNote=WD 3
HgeneSEC13chr3:10362733chr1:150634404ENST00000337354-11011_500326.0RepeatNote=WD 1
HgeneSEC13chr3:10362733chr1:150634404ENST00000337354-110148_2040326.0RepeatNote=WD 4
HgeneSEC13chr3:10362733chr1:150634404ENST00000337354-110210_2530326.0RepeatNote=WD 5
HgeneSEC13chr3:10362733chr1:150634404ENST00000337354-110260_2990326.0RepeatNote=WD 6
HgeneSEC13chr3:10362733chr1:150634404ENST00000337354-11055_960326.0RepeatNote=WD 2
HgeneSEC13chr3:10362733chr1:150634404ENST00000350697-19101_1441323.0RepeatNote=WD 3
HgeneSEC13chr3:10362733chr1:150634404ENST00000350697-1911_501323.0RepeatNote=WD 1
HgeneSEC13chr3:10362733chr1:150634404ENST00000350697-19148_2041323.0RepeatNote=WD 4
HgeneSEC13chr3:10362733chr1:150634404ENST00000350697-19210_2531323.0RepeatNote=WD 5
HgeneSEC13chr3:10362733chr1:150634404ENST00000350697-19260_2991323.0RepeatNote=WD 6
HgeneSEC13chr3:10362733chr1:150634404ENST00000350697-1955_961323.0RepeatNote=WD 2
HgeneSEC13chr3:10362733chr1:150634404ENST00000397109-19101_1440309.0RepeatNote=WD 3
HgeneSEC13chr3:10362733chr1:150634404ENST00000397109-1911_500309.0RepeatNote=WD 1
HgeneSEC13chr3:10362733chr1:150634404ENST00000397109-19148_2040309.0RepeatNote=WD 4
HgeneSEC13chr3:10362733chr1:150634404ENST00000397109-19210_2530309.0RepeatNote=WD 5
HgeneSEC13chr3:10362733chr1:150634404ENST00000397109-19260_2990309.0RepeatNote=WD 6
HgeneSEC13chr3:10362733chr1:150634404ENST00000397109-1955_960309.0RepeatNote=WD 2
HgeneSEC13chr3:10362734chr1:150634404ENST00000337354-110101_1440326.0RepeatNote=WD 3
HgeneSEC13chr3:10362734chr1:150634404ENST00000337354-11011_500326.0RepeatNote=WD 1
HgeneSEC13chr3:10362734chr1:150634404ENST00000337354-110148_2040326.0RepeatNote=WD 4
HgeneSEC13chr3:10362734chr1:150634404ENST00000337354-110210_2530326.0RepeatNote=WD 5
HgeneSEC13chr3:10362734chr1:150634404ENST00000337354-110260_2990326.0RepeatNote=WD 6
HgeneSEC13chr3:10362734chr1:150634404ENST00000337354-11055_960326.0RepeatNote=WD 2
HgeneSEC13chr3:10362734chr1:150634404ENST00000350697-19101_1441323.0RepeatNote=WD 3
HgeneSEC13chr3:10362734chr1:150634404ENST00000350697-1911_501323.0RepeatNote=WD 1
HgeneSEC13chr3:10362734chr1:150634404ENST00000350697-19148_2041323.0RepeatNote=WD 4
HgeneSEC13chr3:10362734chr1:150634404ENST00000350697-19210_2531323.0RepeatNote=WD 5
HgeneSEC13chr3:10362734chr1:150634404ENST00000350697-19260_2991323.0RepeatNote=WD 6
HgeneSEC13chr3:10362734chr1:150634404ENST00000350697-1955_961323.0RepeatNote=WD 2
HgeneSEC13chr3:10362734chr1:150634404ENST00000397109-19101_1440309.0RepeatNote=WD 3
HgeneSEC13chr3:10362734chr1:150634404ENST00000397109-1911_500309.0RepeatNote=WD 1
HgeneSEC13chr3:10362734chr1:150634404ENST00000397109-19148_2040309.0RepeatNote=WD 4
HgeneSEC13chr3:10362734chr1:150634404ENST00000397109-19210_2530309.0RepeatNote=WD 5
HgeneSEC13chr3:10362734chr1:150634404ENST00000397109-19260_2990309.0RepeatNote=WD 6
HgeneSEC13chr3:10362734chr1:150634404ENST00000397109-1955_960309.0RepeatNote=WD 2


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Fusion Gene Sequence for SEC13-GOLPH3L


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>79977_79977_1_SEC13-GOLPH3L_SEC13_chr3_10362733_ENST00000350697_GOLPH3L_chr1_150634404_ENST00000271732_length(transcript)=2768nt_BP=129nt
CCGAGCGCGTTGCTGCCCGGAGGCTCCTACGCCACGGCCCGTCGGGCCCGGCGCCGGAAGTGAGCTGTTCCGAGGCGCCGCCGGGAGCTG
CCACGTCCGAGACCTGGAGCAGCCACCGCCGCAATCATGGTACTGCTAAAGTCAGACAGCCCAACAGGTGATGTTTTACTGGATGAAACT
CTGAAACACATCAAAGCAACTGAACCCACAGAAACTGTCCAAACATGGATAGAGCTACTCACTGGTGAGACCTGGAACCCCTTCAAATTA
CAGTACCAGCTGAGAAATGTACGAGAGCGCATCGCAAAGAACCTAGTAGAGAAAGGTATTCTAACCACTGAGAAGCAGAATTTCCTGCTA
TTTGACATGACTACTCATCCAGTGACCAATACAACAGAGAAACAGCGACTAGTGAAAAAACTTCAAGATAGTGTACTAGAGCGGTGGGTA
AATGACCCTCAGCGTATGGACAAGCGAACACTAGCACTCCTGGTGCTAGCCCACTCCTCTGATGTGCTAGAGAATGTCTTCTCCTCTCTG
ACAGATGACAAGTATGATGTGGCAATGAATCGAGCCAAGGACTTAGTAGAACTGGACCCTGAAGTGGAAGGGACAAAGCCTAGTGCCACA
GAAATGATCTGGGCTGTGCTGGCAGCCTTCAATAAATCTTAAAGCCGGCAGGTGGATTTCTCCTTTTCCCCTGCTGGCTGGTGACTGTCA
GAGACCCCATCACTGAGTTTTGTGTGATGAGATGTTTTCATCATTTTTGTTTCCTTTTCTTGAATCAGACTTGTGATTTGGGGAGAGCAA
CTTCAGGGCTTCTCCATAGACCTTGACCATTATAAGCAGACCTTATTTCTCCCTACACTTCCACTCCATAGGTAAATAAACTGGGTGAAG
CCACACACACCCAATGAACATTTTCTCCCATTTGGTGGTTTAGTTTCACCCAGTGTGCTTTTGGATAAGCAGAAATATCTAAATGGGATT
TTGAGTTCTCCAGCTATAGAATGTGAATGAGATAAAAAGTGAACTATCTATTATATTTTTCTGAGTTTGTTTTCTATCATAAATACATGT
TTTCACAGCCTTTGTCTCTCAGACTCTGCTAAATAATGTAGCTTATTGAAATAACTGTCGCTGAATAAGGAGCAATGAGAAACAAAACTA
ATTTTTGGAGCAGATGGTCTCTGGAATTGCATATCCTGCTAGTGATTTTCTCATCTTTCCTTTTCTAACCTAATGAGAATGTCCCAGATT
CAATTACCTGGATGTCAAAGTCCTAGAGCCAGAAATATATTCTCTCATCCCTCTTAGCATTCTCTTGCTCCCTCATTCACTAGGGCAAAT
GTCTAAATGAAGAAAAGTCTCTCTCAACACCTCGTTCATGCAATCAGCATTAGAATTTGTAAGGAAGGAAGGGGGGTGGCATGAAAATTT
CCATTCTTGGGGTATATGACTGTCCTGTTTCCCCCAGGCCACTTTTTTTTTTTTTTTCTTTTGAGACAGGGTCTTGCTCTTGCCCAGGCA
GGAGTACAGTAGTGCAATCACAGCTGACTGCAGCCTTGACCTCCAGGGCTCAAGGATCCTCCTGCCTCAGTCTCCCAACTAAGTGGGACT
ACAGGCACGTGCCACCATACTCAGCTTTTTTTTGTTTGTTTTAGACAAGAGTCTCGCTTTGTTGCCCAGGCTGGTCTTGAATTCCTGGGC
TCAAGCAATTCTTCCACCTCAGCCTCCCAAAGTGCTGAGATTACTGGCTTGAGCCACTGCACCCACCCCTCCAGACTACTTTAAATGTCT
CTGCTCTGACTGAATTGAAGGAATTGTAAGTTTCAGTTGCTGAATATATCAGTATATCTGAACTCCAGATCTTTTTATTTCCTATTTTTG
GCTTCCTACATAAATTAATAAAGTCTGTCTATATTTAAGGTTTCTGGGAGTAGTTTTGTCTATATTTAATCCATAGATGTGCTCCTAGTC
ATCAGTCTTATTTCAGTAAAACCATCTTTCTGGCCAAATCTCTAACACGTTTTTTACTTCAGTAGTGAGGGCAATGAGAAGCTTTATTAA
GAAAGATCCTATTTAAAGGGCTAATTTGGTATTGAAAGCATGCTGATATAAAGTCCAGTATTTGAGGATATAAAGAGGATGTGCACTGAG
CTGTGCTGATGTTCAGCATTTATTATACTTTAATGGGATAGTGCTTCTTGACCATTATAGAACAACAAACTGTCAAAGGGTTAATACAGA
TGACCCAGACCTGACATTAAATCCTCTTGATTAGAAATAATTAAATGAATTATTTATTCATTTCTCTCCTCTGCCAAATCTACTTAGCCC
CACAAAAATGCCCCAGCTCAGTTAACATTTTTTTGTTTTTCACTTTAGGTATCTCTTAGGCAAATAGAGATATAAATTGTAATAGGAAAC
AGTCTCTAAATGTGAGGCTGAATACAGCTTCAGTCTGGCTCTCTAATAGGACAAAAGCCAGTCCATGTGTTGTCTCTAACTGATTTAGCT
TTTTCTTTTCTTTGAACAATTCGGCATGAATTGAAACCAGGTTTTCCTGTGGAAAGTTATAGCTTGATTGGGAGATAGAAGTTGAATTGA
GTTCTTTCTTGCAACTCTTAGTGTTTATTTTTATATCTCAGTAAGACGAGGATACCTTCAGTTTGAATCTGCATAATGTTCACTGCCAAA

>79977_79977_1_SEC13-GOLPH3L_SEC13_chr3_10362733_ENST00000350697_GOLPH3L_chr1_150634404_ENST00000271732_length(amino acids)=194AA_BP=14
MPRPRPGAATAAIMVLLKSDSPTGDVLLDETLKHIKATEPTETVQTWIELLTGETWNPFKLQYQLRNVRERIAKNLVEKGILTTEKQNFL
LFDMTTHPVTNTTEKQRLVKKLQDSVLERWVNDPQRMDKRTLALLVLAHSSDVLENVFSSLTDDKYDVAMNRAKDLVELDPEVEGTKPSA

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>79977_79977_2_SEC13-GOLPH3L_SEC13_chr3_10362733_ENST00000350697_GOLPH3L_chr1_150634404_ENST00000540514_length(transcript)=782nt_BP=129nt
CCGAGCGCGTTGCTGCCCGGAGGCTCCTACGCCACGGCCCGTCGGGCCCGGCGCCGGAAGTGAGCTGTTCCGAGGCGCCGCCGGGAGCTG
CCACGTCCGAGACCTGGAGCAGCCACCGCCGCAATCATGGTACTGCTAAAGTCAGACAGCCCAACAGGTGATGTTTTACTGGATGAAACT
CTGAAACACATCAAAGCAACTGAACCCACAGAAACTGTCCAAACATGGATAGAGCTACTCACTGGTGAGACCTGGAACCCCTTCAAATTA
CAGTACCAGCTGAGAAATGTACGAGAGCGCATCGCAAAGAACCTAGTAGAGAAAGGTATTCTAACCACTGAGAAGCAGAATTTCCTGCTA
TTTGACATGACTACTCATCCAGTGACCAATACAACAGAGAAACAGCGACTAGTGAAAAAACTTCAAGATAGTGTACTAGAGCGGTGGGTA
AATGACCCTCAGCGTATGGACAAGCGAACACTAGCACTCCTGGTGCTAGCCCACTCCTCTGATGTGCTAGAGAATGTCTTCTCCTCTCTG
ACAGATGACAAGTATGATGTGGCAATGAATCGAGCCAAGGACTTAGTAGAACTGGACCCTGAAGTGGAAGGGACAAAGCCTAGTGCCACA
GAAATGATCTGGGCTGTGCTGGCAGCCTTCAATAAATCTTAAAGCCGGCAGGTGGATTTCTCCTTTTCCCCTGCTGGCTGGTGACTGTCA

>79977_79977_2_SEC13-GOLPH3L_SEC13_chr3_10362733_ENST00000350697_GOLPH3L_chr1_150634404_ENST00000540514_length(amino acids)=194AA_BP=14
MPRPRPGAATAAIMVLLKSDSPTGDVLLDETLKHIKATEPTETVQTWIELLTGETWNPFKLQYQLRNVRERIAKNLVEKGILTTEKQNFL
LFDMTTHPVTNTTEKQRLVKKLQDSVLERWVNDPQRMDKRTLALLVLAHSSDVLENVFSSLTDDKYDVAMNRAKDLVELDPEVEGTKPSA

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>79977_79977_3_SEC13-GOLPH3L_SEC13_chr3_10362734_ENST00000350697_GOLPH3L_chr1_150634404_ENST00000271732_length(transcript)=2768nt_BP=129nt
CCGAGCGCGTTGCTGCCCGGAGGCTCCTACGCCACGGCCCGTCGGGCCCGGCGCCGGAAGTGAGCTGTTCCGAGGCGCCGCCGGGAGCTG
CCACGTCCGAGACCTGGAGCAGCCACCGCCGCAATCATGGTACTGCTAAAGTCAGACAGCCCAACAGGTGATGTTTTACTGGATGAAACT
CTGAAACACATCAAAGCAACTGAACCCACAGAAACTGTCCAAACATGGATAGAGCTACTCACTGGTGAGACCTGGAACCCCTTCAAATTA
CAGTACCAGCTGAGAAATGTACGAGAGCGCATCGCAAAGAACCTAGTAGAGAAAGGTATTCTAACCACTGAGAAGCAGAATTTCCTGCTA
TTTGACATGACTACTCATCCAGTGACCAATACAACAGAGAAACAGCGACTAGTGAAAAAACTTCAAGATAGTGTACTAGAGCGGTGGGTA
AATGACCCTCAGCGTATGGACAAGCGAACACTAGCACTCCTGGTGCTAGCCCACTCCTCTGATGTGCTAGAGAATGTCTTCTCCTCTCTG
ACAGATGACAAGTATGATGTGGCAATGAATCGAGCCAAGGACTTAGTAGAACTGGACCCTGAAGTGGAAGGGACAAAGCCTAGTGCCACA
GAAATGATCTGGGCTGTGCTGGCAGCCTTCAATAAATCTTAAAGCCGGCAGGTGGATTTCTCCTTTTCCCCTGCTGGCTGGTGACTGTCA
GAGACCCCATCACTGAGTTTTGTGTGATGAGATGTTTTCATCATTTTTGTTTCCTTTTCTTGAATCAGACTTGTGATTTGGGGAGAGCAA
CTTCAGGGCTTCTCCATAGACCTTGACCATTATAAGCAGACCTTATTTCTCCCTACACTTCCACTCCATAGGTAAATAAACTGGGTGAAG
CCACACACACCCAATGAACATTTTCTCCCATTTGGTGGTTTAGTTTCACCCAGTGTGCTTTTGGATAAGCAGAAATATCTAAATGGGATT
TTGAGTTCTCCAGCTATAGAATGTGAATGAGATAAAAAGTGAACTATCTATTATATTTTTCTGAGTTTGTTTTCTATCATAAATACATGT
TTTCACAGCCTTTGTCTCTCAGACTCTGCTAAATAATGTAGCTTATTGAAATAACTGTCGCTGAATAAGGAGCAATGAGAAACAAAACTA
ATTTTTGGAGCAGATGGTCTCTGGAATTGCATATCCTGCTAGTGATTTTCTCATCTTTCCTTTTCTAACCTAATGAGAATGTCCCAGATT
CAATTACCTGGATGTCAAAGTCCTAGAGCCAGAAATATATTCTCTCATCCCTCTTAGCATTCTCTTGCTCCCTCATTCACTAGGGCAAAT
GTCTAAATGAAGAAAAGTCTCTCTCAACACCTCGTTCATGCAATCAGCATTAGAATTTGTAAGGAAGGAAGGGGGGTGGCATGAAAATTT
CCATTCTTGGGGTATATGACTGTCCTGTTTCCCCCAGGCCACTTTTTTTTTTTTTTTCTTTTGAGACAGGGTCTTGCTCTTGCCCAGGCA
GGAGTACAGTAGTGCAATCACAGCTGACTGCAGCCTTGACCTCCAGGGCTCAAGGATCCTCCTGCCTCAGTCTCCCAACTAAGTGGGACT
ACAGGCACGTGCCACCATACTCAGCTTTTTTTTGTTTGTTTTAGACAAGAGTCTCGCTTTGTTGCCCAGGCTGGTCTTGAATTCCTGGGC
TCAAGCAATTCTTCCACCTCAGCCTCCCAAAGTGCTGAGATTACTGGCTTGAGCCACTGCACCCACCCCTCCAGACTACTTTAAATGTCT
CTGCTCTGACTGAATTGAAGGAATTGTAAGTTTCAGTTGCTGAATATATCAGTATATCTGAACTCCAGATCTTTTTATTTCCTATTTTTG
GCTTCCTACATAAATTAATAAAGTCTGTCTATATTTAAGGTTTCTGGGAGTAGTTTTGTCTATATTTAATCCATAGATGTGCTCCTAGTC
ATCAGTCTTATTTCAGTAAAACCATCTTTCTGGCCAAATCTCTAACACGTTTTTTACTTCAGTAGTGAGGGCAATGAGAAGCTTTATTAA
GAAAGATCCTATTTAAAGGGCTAATTTGGTATTGAAAGCATGCTGATATAAAGTCCAGTATTTGAGGATATAAAGAGGATGTGCACTGAG
CTGTGCTGATGTTCAGCATTTATTATACTTTAATGGGATAGTGCTTCTTGACCATTATAGAACAACAAACTGTCAAAGGGTTAATACAGA
TGACCCAGACCTGACATTAAATCCTCTTGATTAGAAATAATTAAATGAATTATTTATTCATTTCTCTCCTCTGCCAAATCTACTTAGCCC
CACAAAAATGCCCCAGCTCAGTTAACATTTTTTTGTTTTTCACTTTAGGTATCTCTTAGGCAAATAGAGATATAAATTGTAATAGGAAAC
AGTCTCTAAATGTGAGGCTGAATACAGCTTCAGTCTGGCTCTCTAATAGGACAAAAGCCAGTCCATGTGTTGTCTCTAACTGATTTAGCT
TTTTCTTTTCTTTGAACAATTCGGCATGAATTGAAACCAGGTTTTCCTGTGGAAAGTTATAGCTTGATTGGGAGATAGAAGTTGAATTGA
GTTCTTTCTTGCAACTCTTAGTGTTTATTTTTATATCTCAGTAAGACGAGGATACCTTCAGTTTGAATCTGCATAATGTTCACTGCCAAA

>79977_79977_3_SEC13-GOLPH3L_SEC13_chr3_10362734_ENST00000350697_GOLPH3L_chr1_150634404_ENST00000271732_length(amino acids)=194AA_BP=14
MPRPRPGAATAAIMVLLKSDSPTGDVLLDETLKHIKATEPTETVQTWIELLTGETWNPFKLQYQLRNVRERIAKNLVEKGILTTEKQNFL
LFDMTTHPVTNTTEKQRLVKKLQDSVLERWVNDPQRMDKRTLALLVLAHSSDVLENVFSSLTDDKYDVAMNRAKDLVELDPEVEGTKPSA

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>79977_79977_4_SEC13-GOLPH3L_SEC13_chr3_10362734_ENST00000350697_GOLPH3L_chr1_150634404_ENST00000540514_length(transcript)=782nt_BP=129nt
CCGAGCGCGTTGCTGCCCGGAGGCTCCTACGCCACGGCCCGTCGGGCCCGGCGCCGGAAGTGAGCTGTTCCGAGGCGCCGCCGGGAGCTG
CCACGTCCGAGACCTGGAGCAGCCACCGCCGCAATCATGGTACTGCTAAAGTCAGACAGCCCAACAGGTGATGTTTTACTGGATGAAACT
CTGAAACACATCAAAGCAACTGAACCCACAGAAACTGTCCAAACATGGATAGAGCTACTCACTGGTGAGACCTGGAACCCCTTCAAATTA
CAGTACCAGCTGAGAAATGTACGAGAGCGCATCGCAAAGAACCTAGTAGAGAAAGGTATTCTAACCACTGAGAAGCAGAATTTCCTGCTA
TTTGACATGACTACTCATCCAGTGACCAATACAACAGAGAAACAGCGACTAGTGAAAAAACTTCAAGATAGTGTACTAGAGCGGTGGGTA
AATGACCCTCAGCGTATGGACAAGCGAACACTAGCACTCCTGGTGCTAGCCCACTCCTCTGATGTGCTAGAGAATGTCTTCTCCTCTCTG
ACAGATGACAAGTATGATGTGGCAATGAATCGAGCCAAGGACTTAGTAGAACTGGACCCTGAAGTGGAAGGGACAAAGCCTAGTGCCACA
GAAATGATCTGGGCTGTGCTGGCAGCCTTCAATAAATCTTAAAGCCGGCAGGTGGATTTCTCCTTTTCCCCTGCTGGCTGGTGACTGTCA

>79977_79977_4_SEC13-GOLPH3L_SEC13_chr3_10362734_ENST00000350697_GOLPH3L_chr1_150634404_ENST00000540514_length(amino acids)=194AA_BP=14
MPRPRPGAATAAIMVLLKSDSPTGDVLLDETLKHIKATEPTETVQTWIELLTGETWNPFKLQYQLRNVRERIAKNLVEKGILTTEKQNFL
LFDMTTHPVTNTTEKQRLVKKLQDSVLERWVNDPQRMDKRTLALLVLAHSSDVLENVFSSLTDDKYDVAMNRAKDLVELDPEVEGTKPSA

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Fusion Gene PPI Analysis for SEC13-GOLPH3L


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for SEC13-GOLPH3L


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for SEC13-GOLPH3L


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource