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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:SEC23A-PSMC1 (FusionGDB2 ID:80049)

Fusion Gene Summary for SEC23A-PSMC1

check button Fusion gene summary
Fusion gene informationFusion gene name: SEC23A-PSMC1
Fusion gene ID: 80049
HgeneTgene
Gene symbol

SEC23A

PSMC1

Gene ID

10484

5700

Gene nameSec23 homolog A, COPII coat complex componentproteasome 26S subunit, ATPase 1
SynonymsCLSD|hSec23AP26S4|S4|p56
Cytomap

14q21.1

14q32.11

Type of geneprotein-codingprotein-coding
Descriptionprotein transport protein Sec23ASEC23-related protein ASec23 homolog A, coat complex II component26S proteasome regulatory subunit 426S protease regulatory subunit 426S proteasome AAA-ATPase subunit RPT2proteasome (prosome, macropain) 26S subunit, ATPase, 1proteasome 26S ATPase subunit 1
Modification date2020032720200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000307712, ENST00000545328, 
ENST00000548032, ENST00000553970, 
ENST00000557280, ENST00000536508, 
ENST00000537403, ENST00000553925, 
ENST00000261303, ENST00000543772, 
Fusion gene scores* DoF score10 X 12 X 6=7203 X 4 X 2=24
# samples 124
** MAII scorelog2(12/720*10)=-2.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(4/24*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: SEC23A [Title/Abstract] AND PSMC1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointSEC23A(39565102)-PSMC1(90738617), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneSEC23A

GO:0090110

cargo loading into COPII-coated vesicle

17499046|18843296


check buttonFusion gene breakpoints across SEC23A (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across PSMC1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-E2-A15P-01ASEC23Achr14

39565102

-PSMC1chr14

90738617

+
ChimerDB4BRCATCGA-E2-A15PSEC23Achr14

39565101

-PSMC1chr14

90738616

+


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Fusion Gene ORF analysis for SEC23A-PSMC1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000307712ENST00000261303SEC23Achr14

39565102

-PSMC1chr14

90738617

+
In-frameENST00000307712ENST00000261303SEC23Achr14

39565101

-PSMC1chr14

90738616

+
In-frameENST00000307712ENST00000543772SEC23Achr14

39565102

-PSMC1chr14

90738617

+
In-frameENST00000307712ENST00000543772SEC23Achr14

39565101

-PSMC1chr14

90738616

+
In-frameENST00000545328ENST00000261303SEC23Achr14

39565102

-PSMC1chr14

90738617

+
In-frameENST00000545328ENST00000261303SEC23Achr14

39565101

-PSMC1chr14

90738616

+
In-frameENST00000545328ENST00000543772SEC23Achr14

39565102

-PSMC1chr14

90738617

+
In-frameENST00000545328ENST00000543772SEC23Achr14

39565101

-PSMC1chr14

90738616

+
In-frameENST00000548032ENST00000261303SEC23Achr14

39565102

-PSMC1chr14

90738617

+
In-frameENST00000548032ENST00000261303SEC23Achr14

39565101

-PSMC1chr14

90738616

+
In-frameENST00000548032ENST00000543772SEC23Achr14

39565102

-PSMC1chr14

90738617

+
In-frameENST00000548032ENST00000543772SEC23Achr14

39565101

-PSMC1chr14

90738616

+
In-frameENST00000553970ENST00000261303SEC23Achr14

39565102

-PSMC1chr14

90738617

+
In-frameENST00000553970ENST00000261303SEC23Achr14

39565101

-PSMC1chr14

90738616

+
In-frameENST00000553970ENST00000543772SEC23Achr14

39565102

-PSMC1chr14

90738617

+
In-frameENST00000553970ENST00000543772SEC23Achr14

39565101

-PSMC1chr14

90738616

+
In-frameENST00000557280ENST00000261303SEC23Achr14

39565102

-PSMC1chr14

90738617

+
In-frameENST00000557280ENST00000261303SEC23Achr14

39565101

-PSMC1chr14

90738616

+
In-frameENST00000557280ENST00000543772SEC23Achr14

39565102

-PSMC1chr14

90738617

+
In-frameENST00000557280ENST00000543772SEC23Achr14

39565101

-PSMC1chr14

90738616

+
intron-3CDSENST00000536508ENST00000261303SEC23Achr14

39565102

-PSMC1chr14

90738617

+
intron-3CDSENST00000536508ENST00000261303SEC23Achr14

39565101

-PSMC1chr14

90738616

+
intron-3CDSENST00000536508ENST00000543772SEC23Achr14

39565102

-PSMC1chr14

90738617

+
intron-3CDSENST00000536508ENST00000543772SEC23Achr14

39565101

-PSMC1chr14

90738616

+
intron-3CDSENST00000537403ENST00000261303SEC23Achr14

39565102

-PSMC1chr14

90738617

+
intron-3CDSENST00000537403ENST00000261303SEC23Achr14

39565101

-PSMC1chr14

90738616

+
intron-3CDSENST00000537403ENST00000543772SEC23Achr14

39565102

-PSMC1chr14

90738617

+
intron-3CDSENST00000537403ENST00000543772SEC23Achr14

39565101

-PSMC1chr14

90738616

+
intron-3CDSENST00000553925ENST00000261303SEC23Achr14

39565102

-PSMC1chr14

90738617

+
intron-3CDSENST00000553925ENST00000261303SEC23Achr14

39565101

-PSMC1chr14

90738616

+
intron-3CDSENST00000553925ENST00000543772SEC23Achr14

39565102

-PSMC1chr14

90738617

+
intron-3CDSENST00000553925ENST00000543772SEC23Achr14

39565101

-PSMC1chr14

90738616

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000307712SEC23Achr1439565102-ENST00000261303PSMC1chr1490738617+1089739524195109
ENST00000307712SEC23Achr1439565102-ENST00000543772PSMC1chr1490738617+1017739524195109
ENST00000545328SEC23Achr1439565102-ENST00000261303PSMC1chr1490738617+79644677547699
ENST00000545328SEC23Achr1439565102-ENST00000543772PSMC1chr1490738617+72444622547081
ENST00000548032SEC23Achr1439565102-ENST00000261303PSMC1chr1490738617+77342375245399
ENST00000548032SEC23Achr1439565102-ENST00000543772PSMC1chr1490738617+70142320244781
ENST00000557280SEC23Achr1439565102-ENST00000261303PSMC1chr1490738617+79444477347499
ENST00000557280SEC23Achr1439565102-ENST00000543772PSMC1chr1490738617+72244422346881
ENST00000553970SEC23Achr1439565102-ENST00000261303PSMC1chr1490738617+80445478348499
ENST00000553970SEC23Achr1439565102-ENST00000543772PSMC1chr1490738617+73245423347881
ENST00000307712SEC23Achr1439565101-ENST00000261303PSMC1chr1490738616+1089739524195109
ENST00000307712SEC23Achr1439565101-ENST00000543772PSMC1chr1490738616+1017739524195109
ENST00000545328SEC23Achr1439565101-ENST00000261303PSMC1chr1490738616+79644677547699
ENST00000545328SEC23Achr1439565101-ENST00000543772PSMC1chr1490738616+72444622547081
ENST00000548032SEC23Achr1439565101-ENST00000261303PSMC1chr1490738616+77342375245399
ENST00000548032SEC23Achr1439565101-ENST00000543772PSMC1chr1490738616+70142320244781
ENST00000557280SEC23Achr1439565101-ENST00000261303PSMC1chr1490738616+79444477347499
ENST00000557280SEC23Achr1439565101-ENST00000543772PSMC1chr1490738616+72244422346881
ENST00000553970SEC23Achr1439565101-ENST00000261303PSMC1chr1490738616+80445478348499
ENST00000553970SEC23Achr1439565101-ENST00000543772PSMC1chr1490738616+73245423347881

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000307712ENST00000261303SEC23Achr1439565102-PSMC1chr1490738617+0.67278950.3272105
ENST00000307712ENST00000543772SEC23Achr1439565102-PSMC1chr1490738617+0.49515820.5048418
ENST00000545328ENST00000261303SEC23Achr1439565102-PSMC1chr1490738617+0.35710810.64289194
ENST00000545328ENST00000543772SEC23Achr1439565102-PSMC1chr1490738617+0.191625650.80837435
ENST00000548032ENST00000261303SEC23Achr1439565102-PSMC1chr1490738617+0.336511280.6634887
ENST00000548032ENST00000543772SEC23Achr1439565102-PSMC1chr1490738617+0.169805470.8301946
ENST00000557280ENST00000261303SEC23Achr1439565102-PSMC1chr1490738617+0.354146450.6458535
ENST00000557280ENST00000543772SEC23Achr1439565102-PSMC1chr1490738617+0.188884270.8111157
ENST00000553970ENST00000261303SEC23Achr1439565102-PSMC1chr1490738617+0.328151940.67184806
ENST00000553970ENST00000543772SEC23Achr1439565102-PSMC1chr1490738617+0.183952450.81604755
ENST00000307712ENST00000261303SEC23Achr1439565101-PSMC1chr1490738616+0.67278950.3272105
ENST00000307712ENST00000543772SEC23Achr1439565101-PSMC1chr1490738616+0.49515820.5048418
ENST00000545328ENST00000261303SEC23Achr1439565101-PSMC1chr1490738616+0.35710810.64289194
ENST00000545328ENST00000543772SEC23Achr1439565101-PSMC1chr1490738616+0.191625650.80837435
ENST00000548032ENST00000261303SEC23Achr1439565101-PSMC1chr1490738616+0.336511280.6634887
ENST00000548032ENST00000543772SEC23Achr1439565101-PSMC1chr1490738616+0.169805470.8301946
ENST00000557280ENST00000261303SEC23Achr1439565101-PSMC1chr1490738616+0.354146450.6458535
ENST00000557280ENST00000543772SEC23Achr1439565101-PSMC1chr1490738616+0.188884270.8111157
ENST00000553970ENST00000261303SEC23Achr1439565101-PSMC1chr1490738616+0.328151940.67184806
ENST00000553970ENST00000543772SEC23Achr1439565101-PSMC1chr1490738616+0.183952450.81604755

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Fusion Genomic Features for SEC23A-PSMC1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
SEC23Achr1439565101-PSMC1chr1490738616+0.0001276540.9998723
SEC23Achr1439565101-PSMC1chr1490738616+0.0001276540.9998723
SEC23Achr1439565101-PSMC1chr1490738616+0.0001276540.9998723
SEC23Achr1439565101-PSMC1chr1490738616+0.0001276540.9998723

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for SEC23A-PSMC1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr14:39565102/chr14:90738617)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSEC23Achr14:39565101chr14:90738616ENST00000307712-220632_71873766.0RepeatGelsolin-like
HgeneSEC23Achr14:39565102chr14:90738617ENST00000307712-220632_71873766.0RepeatGelsolin-like
TgenePSMC1chr14:39565101chr14:90738616ENST00000261303911226_233396441.0Nucleotide bindingATP
TgenePSMC1chr14:39565102chr14:90738617ENST00000261303911226_233396441.0Nucleotide bindingATP


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Fusion Gene Sequence for SEC23A-PSMC1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>80049_80049_1_SEC23A-PSMC1_SEC23A_chr14_39565101_ENST00000307712_PSMC1_chr14_90738616_ENST00000261303_length(transcript)=1089nt_BP=739nt
ACGCTGTGGCTTTAGGGAGCTGGGAAAGGCGCTCTCTCCCGGTCCCGCTCTGCCCGGTCCCACGCCCCTCGGCCGTCCGGCTGCCTGGGT
CTTCCGGGTTCTTCCGCCCCTCTGGCTCGGTCCCCGCTACCTCTCCTCCCTCCTCCCCTCTCGGTACCTTCGCCCGCCGCGCGCCTTTCT
CAAATCCTCCGGTTATTAAGCAAGCTCAGGGGTCCGGTGGCCTGCCCTGGTAACTCTGCGCCCGCCCCTTCCTGCCCCCTTCCTGCCCTC
ACGCCCCGTCCCCTCCTCTTGACGTGGCAGAGGCGGCGCCAGCCATGTTGGCCGGGCGGAGGTCTTCGCTGAGGCCCGGGGCGGGGTGGC
GCCACCCCTGATTGCGGTGCCACGGACTGCTCCTGCTGGGCGGAGAGGACAGATTTTGCAAAGCGGAGGCTGCGACGGGTCCTGCAGGGG
GACAGTGAGGAAAGGGCCGCCTCGTCTCCGCTCCTGGGGGACCGCAGAAATAAGAATCAAACTCCACAATGACAACCTATTTGGAATTCA
TTCAACAAAATGAAGAACGAGATGGAGTCCGATTTAGTTGGAATGTTTGGCCATCAAGTCGACTGGAAGCTACAAGAATGGTTGTTCCTG
TGGCAGCCCTGTTTACACCACTGAAAGAGAGACCTGACTTACCACCTATTCAATATGAACCTGTTCTGTGTAGTAGGACCACTTGCCGTG
CAGTTTTGAATCCTTTATGGCAATCTGTACAGAAGCTGGTCTGATGGCCTTAAGAGAACGTAGAATGAAAGTAACAAATGAAGACTTCAA
AAAATCTAAAGAAAATGTTCTTTATAAGAAACAGGAAGGCACCCCTGAGGGGCTGTATCTCTAATGAACCATGGCTGTCATCAGGAAAAT
GGTTGGGAGATTTCTCAATCCCTGAAAGGGATGAGGTTGGGGGAGTTGCCCAGAGGAATCCCTGTTCCCACTGATTTTTATTAGCAAAAC
ATCCTGTGTCTTTTGGAGTACGATGTGTAAGTGCCCATTGGGTGGCCTGTTGGTCACTGTGCAGCAGTCTGCTTCCCAATAAAGCGTGCT

>80049_80049_1_SEC23A-PSMC1_SEC23A_chr14_39565101_ENST00000307712_PSMC1_chr14_90738616_ENST00000261303_length(amino acids)=109AA_BP=
MSLWSLILISAVPQERRRGGPFLTVPLQDPSQPPLCKICPLRPAGAVRGTAIRGGATPPRASAKTSARPTWLAPPLPRQEEGTGREGRKG

--------------------------------------------------------------
>80049_80049_2_SEC23A-PSMC1_SEC23A_chr14_39565101_ENST00000307712_PSMC1_chr14_90738616_ENST00000543772_length(transcript)=1017nt_BP=739nt
ACGCTGTGGCTTTAGGGAGCTGGGAAAGGCGCTCTCTCCCGGTCCCGCTCTGCCCGGTCCCACGCCCCTCGGCCGTCCGGCTGCCTGGGT
CTTCCGGGTTCTTCCGCCCCTCTGGCTCGGTCCCCGCTACCTCTCCTCCCTCCTCCCCTCTCGGTACCTTCGCCCGCCGCGCGCCTTTCT
CAAATCCTCCGGTTATTAAGCAAGCTCAGGGGTCCGGTGGCCTGCCCTGGTAACTCTGCGCCCGCCCCTTCCTGCCCCCTTCCTGCCCTC
ACGCCCCGTCCCCTCCTCTTGACGTGGCAGAGGCGGCGCCAGCCATGTTGGCCGGGCGGAGGTCTTCGCTGAGGCCCGGGGCGGGGTGGC
GCCACCCCTGATTGCGGTGCCACGGACTGCTCCTGCTGGGCGGAGAGGACAGATTTTGCAAAGCGGAGGCTGCGACGGGTCCTGCAGGGG
GACAGTGAGGAAAGGGCCGCCTCGTCTCCGCTCCTGGGGGACCGCAGAAATAAGAATCAAACTCCACAATGACAACCTATTTGGAATTCA
TTCAACAAAATGAAGAACGAGATGGAGTCCGATTTAGTTGGAATGTTTGGCCATCAAGTCGACTGGAAGCTACAAGAATGGTTGTTCCTG
TGGCAGCCCTGTTTACACCACTGAAAGAGAGACCTGACTTACCACCTATTCAATATGAACCTGTTCTGTGTAGTAGGACCACTTGCCGTG
CAGTTTTGAATCCTTTATGGCAATCTGTACAGAAGCTGGTCTGATGGCCTTAAGAGAACGTAGAATGAAAGTAACAAATGAAGACTTCAA
AAAATCTAAAGAAAATGTTCTTTATAAGAAACAGGAAGGCACCCCTGAGGGGCTGTATCTCTAATGAACCATGGCTGTCATCAGGAAAAT
GGTTGGGAGATTTCTCAATCCCTGAAAGGGATGAGGTTGGGGGAGTTGCCCAGAGGAATCCCTGTTCCCACTGATTTTTATTAGCAAAAC

>80049_80049_2_SEC23A-PSMC1_SEC23A_chr14_39565101_ENST00000307712_PSMC1_chr14_90738616_ENST00000543772_length(amino acids)=109AA_BP=
MSLWSLILISAVPQERRRGGPFLTVPLQDPSQPPLCKICPLRPAGAVRGTAIRGGATPPRASAKTSARPTWLAPPLPRQEEGTGREGRKG

--------------------------------------------------------------
>80049_80049_3_SEC23A-PSMC1_SEC23A_chr14_39565101_ENST00000545328_PSMC1_chr14_90738616_ENST00000261303_length(transcript)=796nt_BP=446nt
GTGGCAGAGGCGGCGCCAGCCATGTTGGCCGGGCGGAGGTCTTCGCTGAGGCCCGGGGCGGGGTGGCGCCACCCCTGATTGCGGTGCCAC
GGACTGCTCCTGCTGGGCGGAGAGGACAGATTTTGCAAAGCGGAGGCTGCGACGGGTCCTGCAGGGGGACAGTGAGGAAAGGGCCGCCTC
GTCTCCGCTCCTGGGGGACCGCAGAAATAAGAATCAAACTCCACAATGACAACCTATTTGGAATTCATTCAACAAAATGAAGAACGAGAT
GGAGTCCGATTTAGTTGGAATGTTTGGCCATCAAGTCGACTGGAAGCTACAAGAATGGTTGTTCCTGTGGCAGCCCTGTTTACACCACTG
AAAGAGAGACCTGACTTACCACCTATTCAATATGAACCTGTTCTGTGTAGTAGGACCACTTGCCGTGCAGTTTTGAATCCTTTATGGCAA
TCTGTACAGAAGCTGGTCTGATGGCCTTAAGAGAACGTAGAATGAAAGTAACAAATGAAGACTTCAAAAAATCTAAAGAAAATGTTCTTT
ATAAGAAACAGGAAGGCACCCCTGAGGGGCTGTATCTCTAATGAACCATGGCTGTCATCAGGAAAATGGTTGGGAGATTTCTCAATCCCT
GAAAGGGATGAGGTTGGGGGAGTTGCCCAGAGGAATCCCTGTTCCCACTGATTTTTATTAGCAAAACATCCTGTGTCTTTTGGAGTACGA

>80049_80049_3_SEC23A-PSMC1_SEC23A_chr14_39565101_ENST00000545328_PSMC1_chr14_90738616_ENST00000261303_length(amino acids)=99AA_BP=
MGSRLLHSDQQATQWALTHRTPKDTGCFANKNQWEQGFLWATPPTSSLSGIEKSPNHFPDDSHGSLEIQPLRGAFLFLIKNIFFRFFEVF

--------------------------------------------------------------
>80049_80049_4_SEC23A-PSMC1_SEC23A_chr14_39565101_ENST00000545328_PSMC1_chr14_90738616_ENST00000543772_length(transcript)=724nt_BP=446nt
GTGGCAGAGGCGGCGCCAGCCATGTTGGCCGGGCGGAGGTCTTCGCTGAGGCCCGGGGCGGGGTGGCGCCACCCCTGATTGCGGTGCCAC
GGACTGCTCCTGCTGGGCGGAGAGGACAGATTTTGCAAAGCGGAGGCTGCGACGGGTCCTGCAGGGGGACAGTGAGGAAAGGGCCGCCTC
GTCTCCGCTCCTGGGGGACCGCAGAAATAAGAATCAAACTCCACAATGACAACCTATTTGGAATTCATTCAACAAAATGAAGAACGAGAT
GGAGTCCGATTTAGTTGGAATGTTTGGCCATCAAGTCGACTGGAAGCTACAAGAATGGTTGTTCCTGTGGCAGCCCTGTTTACACCACTG
AAAGAGAGACCTGACTTACCACCTATTCAATATGAACCTGTTCTGTGTAGTAGGACCACTTGCCGTGCAGTTTTGAATCCTTTATGGCAA
TCTGTACAGAAGCTGGTCTGATGGCCTTAAGAGAACGTAGAATGAAAGTAACAAATGAAGACTTCAAAAAATCTAAAGAAAATGTTCTTT
ATAAGAAACAGGAAGGCACCCCTGAGGGGCTGTATCTCTAATGAACCATGGCTGTCATCAGGAAAATGGTTGGGAGATTTCTCAATCCCT
GAAAGGGATGAGGTTGGGGGAGTTGCCCAGAGGAATCCCTGTTCCCACTGATTTTTATTAGCAAAACATCCTGTGTCTTTTGGAGTACGA

>80049_80049_4_SEC23A-PSMC1_SEC23A_chr14_39565101_ENST00000545328_PSMC1_chr14_90738616_ENST00000543772_length(amino acids)=81AA_BP=

--------------------------------------------------------------
>80049_80049_5_SEC23A-PSMC1_SEC23A_chr14_39565101_ENST00000548032_PSMC1_chr14_90738616_ENST00000261303_length(transcript)=773nt_BP=423nt
GTTGGCCGGGCGGAGGTCTTCGCTGAGGCCCGGGGCGGGGTGGCGCCACCCCTGATTGCGGTGCCACGGACTGCTCCTGCTGGGCGGAGA
GGACAGATTTTGCAAAGCGGAGGCTGCGACGGGTCCTGCAGGGGGACAGTGAGGAAAGGGCCGCCTCGTCTCCGCTCCTGGGGGACCGCA
GAAATAAGAATCAAACTCCACAATGACAACCTATTTGGAATTCATTCAACAAAATGAAGAACGAGATGGAGTCCGATTTAGTTGGAATGT
TTGGCCATCAAGTCGACTGGAAGCTACAAGAATGGTTGTTCCTGTGGCAGCCCTGTTTACACCACTGAAAGAGAGACCTGACTTACCACC
TATTCAATATGAACCTGTTCTGTGTAGTAGGACCACTTGCCGTGCAGTTTTGAATCCTTTATGGCAATCTGTACAGAAGCTGGTCTGATG
GCCTTAAGAGAACGTAGAATGAAAGTAACAAATGAAGACTTCAAAAAATCTAAAGAAAATGTTCTTTATAAGAAACAGGAAGGCACCCCT
GAGGGGCTGTATCTCTAATGAACCATGGCTGTCATCAGGAAAATGGTTGGGAGATTTCTCAATCCCTGAAAGGGATGAGGTTGGGGGAGT
TGCCCAGAGGAATCCCTGTTCCCACTGATTTTTATTAGCAAAACATCCTGTGTCTTTTGGAGTACGATGTGTAAGTGCCCATTGGGTGGC

>80049_80049_5_SEC23A-PSMC1_SEC23A_chr14_39565101_ENST00000548032_PSMC1_chr14_90738616_ENST00000261303_length(amino acids)=99AA_BP=
MGSRLLHSDQQATQWALTHRTPKDTGCFANKNQWEQGFLWATPPTSSLSGIEKSPNHFPDDSHGSLEIQPLRGAFLFLIKNIFFRFFEVF

--------------------------------------------------------------
>80049_80049_6_SEC23A-PSMC1_SEC23A_chr14_39565101_ENST00000548032_PSMC1_chr14_90738616_ENST00000543772_length(transcript)=701nt_BP=423nt
GTTGGCCGGGCGGAGGTCTTCGCTGAGGCCCGGGGCGGGGTGGCGCCACCCCTGATTGCGGTGCCACGGACTGCTCCTGCTGGGCGGAGA
GGACAGATTTTGCAAAGCGGAGGCTGCGACGGGTCCTGCAGGGGGACAGTGAGGAAAGGGCCGCCTCGTCTCCGCTCCTGGGGGACCGCA
GAAATAAGAATCAAACTCCACAATGACAACCTATTTGGAATTCATTCAACAAAATGAAGAACGAGATGGAGTCCGATTTAGTTGGAATGT
TTGGCCATCAAGTCGACTGGAAGCTACAAGAATGGTTGTTCCTGTGGCAGCCCTGTTTACACCACTGAAAGAGAGACCTGACTTACCACC
TATTCAATATGAACCTGTTCTGTGTAGTAGGACCACTTGCCGTGCAGTTTTGAATCCTTTATGGCAATCTGTACAGAAGCTGGTCTGATG
GCCTTAAGAGAACGTAGAATGAAAGTAACAAATGAAGACTTCAAAAAATCTAAAGAAAATGTTCTTTATAAGAAACAGGAAGGCACCCCT
GAGGGGCTGTATCTCTAATGAACCATGGCTGTCATCAGGAAAATGGTTGGGAGATTTCTCAATCCCTGAAAGGGATGAGGTTGGGGGAGT

>80049_80049_6_SEC23A-PSMC1_SEC23A_chr14_39565101_ENST00000548032_PSMC1_chr14_90738616_ENST00000543772_length(amino acids)=81AA_BP=

--------------------------------------------------------------
>80049_80049_7_SEC23A-PSMC1_SEC23A_chr14_39565101_ENST00000553970_PSMC1_chr14_90738616_ENST00000261303_length(transcript)=804nt_BP=454nt
CTCTTGACGTGGCAGAGGCGGCGCCAGCCATGTTGGCCGGGCGGAGGTCTTCGCTGAGGCCCGGGGCGGGGTGGCGCCACCCCTGATTGC
GGTGCCACGGACTGCTCCTGCTGGGCGGAGAGGACAGATTTTGCAAAGCGGAGGCTGCGACGGGTCCTGCAGGGGGACAGTGAGGAAAGG
GCCGCCTCGTCTCCGCTCCTGGGGGACCGCAGAAATAAGAATCAAACTCCACAATGACAACCTATTTGGAATTCATTCAACAAAATGAAG
AACGAGATGGAGTCCGATTTAGTTGGAATGTTTGGCCATCAAGTCGACTGGAAGCTACAAGAATGGTTGTTCCTGTGGCAGCCCTGTTTA
CACCACTGAAAGAGAGACCTGACTTACCACCTATTCAATATGAACCTGTTCTGTGTAGTAGGACCACTTGCCGTGCAGTTTTGAATCCTT
TATGGCAATCTGTACAGAAGCTGGTCTGATGGCCTTAAGAGAACGTAGAATGAAAGTAACAAATGAAGACTTCAAAAAATCTAAAGAAAA
TGTTCTTTATAAGAAACAGGAAGGCACCCCTGAGGGGCTGTATCTCTAATGAACCATGGCTGTCATCAGGAAAATGGTTGGGAGATTTCT
CAATCCCTGAAAGGGATGAGGTTGGGGGAGTTGCCCAGAGGAATCCCTGTTCCCACTGATTTTTATTAGCAAAACATCCTGTGTCTTTTG

>80049_80049_7_SEC23A-PSMC1_SEC23A_chr14_39565101_ENST00000553970_PSMC1_chr14_90738616_ENST00000261303_length(amino acids)=99AA_BP=
MGSRLLHSDQQATQWALTHRTPKDTGCFANKNQWEQGFLWATPPTSSLSGIEKSPNHFPDDSHGSLEIQPLRGAFLFLIKNIFFRFFEVF

--------------------------------------------------------------
>80049_80049_8_SEC23A-PSMC1_SEC23A_chr14_39565101_ENST00000553970_PSMC1_chr14_90738616_ENST00000543772_length(transcript)=732nt_BP=454nt
CTCTTGACGTGGCAGAGGCGGCGCCAGCCATGTTGGCCGGGCGGAGGTCTTCGCTGAGGCCCGGGGCGGGGTGGCGCCACCCCTGATTGC
GGTGCCACGGACTGCTCCTGCTGGGCGGAGAGGACAGATTTTGCAAAGCGGAGGCTGCGACGGGTCCTGCAGGGGGACAGTGAGGAAAGG
GCCGCCTCGTCTCCGCTCCTGGGGGACCGCAGAAATAAGAATCAAACTCCACAATGACAACCTATTTGGAATTCATTCAACAAAATGAAG
AACGAGATGGAGTCCGATTTAGTTGGAATGTTTGGCCATCAAGTCGACTGGAAGCTACAAGAATGGTTGTTCCTGTGGCAGCCCTGTTTA
CACCACTGAAAGAGAGACCTGACTTACCACCTATTCAATATGAACCTGTTCTGTGTAGTAGGACCACTTGCCGTGCAGTTTTGAATCCTT
TATGGCAATCTGTACAGAAGCTGGTCTGATGGCCTTAAGAGAACGTAGAATGAAAGTAACAAATGAAGACTTCAAAAAATCTAAAGAAAA
TGTTCTTTATAAGAAACAGGAAGGCACCCCTGAGGGGCTGTATCTCTAATGAACCATGGCTGTCATCAGGAAAATGGTTGGGAGATTTCT
CAATCCCTGAAAGGGATGAGGTTGGGGGAGTTGCCCAGAGGAATCCCTGTTCCCACTGATTTTTATTAGCAAAACATCCTGTGTCTTTTG

>80049_80049_8_SEC23A-PSMC1_SEC23A_chr14_39565101_ENST00000553970_PSMC1_chr14_90738616_ENST00000543772_length(amino acids)=81AA_BP=

--------------------------------------------------------------
>80049_80049_9_SEC23A-PSMC1_SEC23A_chr14_39565101_ENST00000557280_PSMC1_chr14_90738616_ENST00000261303_length(transcript)=794nt_BP=444nt
GGCAGAGGCGGCGCCAGCCATGTTGGCCGGGCGGAGGTCTTCGCTGAGGCCCGGGGCGGGGTGGCGCCACCCCTGATTGCGGTGCCACGG
ACTGCTCCTGCTGGGCGGAGAGGACAGATTTTGCAAAGCGGAGGCTGCGACGGGTCCTGCAGGGGGACAGTGAGGAAAGGGCCGCCTCGT
CTCCGCTCCTGGGGGACCGCAGAAATAAGAATCAAACTCCACAATGACAACCTATTTGGAATTCATTCAACAAAATGAAGAACGAGATGG
AGTCCGATTTAGTTGGAATGTTTGGCCATCAAGTCGACTGGAAGCTACAAGAATGGTTGTTCCTGTGGCAGCCCTGTTTACACCACTGAA
AGAGAGACCTGACTTACCACCTATTCAATATGAACCTGTTCTGTGTAGTAGGACCACTTGCCGTGCAGTTTTGAATCCTTTATGGCAATC
TGTACAGAAGCTGGTCTGATGGCCTTAAGAGAACGTAGAATGAAAGTAACAAATGAAGACTTCAAAAAATCTAAAGAAAATGTTCTTTAT
AAGAAACAGGAAGGCACCCCTGAGGGGCTGTATCTCTAATGAACCATGGCTGTCATCAGGAAAATGGTTGGGAGATTTCTCAATCCCTGA
AAGGGATGAGGTTGGGGGAGTTGCCCAGAGGAATCCCTGTTCCCACTGATTTTTATTAGCAAAACATCCTGTGTCTTTTGGAGTACGATG

>80049_80049_9_SEC23A-PSMC1_SEC23A_chr14_39565101_ENST00000557280_PSMC1_chr14_90738616_ENST00000261303_length(amino acids)=99AA_BP=
MGSRLLHSDQQATQWALTHRTPKDTGCFANKNQWEQGFLWATPPTSSLSGIEKSPNHFPDDSHGSLEIQPLRGAFLFLIKNIFFRFFEVF

--------------------------------------------------------------
>80049_80049_10_SEC23A-PSMC1_SEC23A_chr14_39565101_ENST00000557280_PSMC1_chr14_90738616_ENST00000543772_length(transcript)=722nt_BP=444nt
GGCAGAGGCGGCGCCAGCCATGTTGGCCGGGCGGAGGTCTTCGCTGAGGCCCGGGGCGGGGTGGCGCCACCCCTGATTGCGGTGCCACGG
ACTGCTCCTGCTGGGCGGAGAGGACAGATTTTGCAAAGCGGAGGCTGCGACGGGTCCTGCAGGGGGACAGTGAGGAAAGGGCCGCCTCGT
CTCCGCTCCTGGGGGACCGCAGAAATAAGAATCAAACTCCACAATGACAACCTATTTGGAATTCATTCAACAAAATGAAGAACGAGATGG
AGTCCGATTTAGTTGGAATGTTTGGCCATCAAGTCGACTGGAAGCTACAAGAATGGTTGTTCCTGTGGCAGCCCTGTTTACACCACTGAA
AGAGAGACCTGACTTACCACCTATTCAATATGAACCTGTTCTGTGTAGTAGGACCACTTGCCGTGCAGTTTTGAATCCTTTATGGCAATC
TGTACAGAAGCTGGTCTGATGGCCTTAAGAGAACGTAGAATGAAAGTAACAAATGAAGACTTCAAAAAATCTAAAGAAAATGTTCTTTAT
AAGAAACAGGAAGGCACCCCTGAGGGGCTGTATCTCTAATGAACCATGGCTGTCATCAGGAAAATGGTTGGGAGATTTCTCAATCCCTGA
AAGGGATGAGGTTGGGGGAGTTGCCCAGAGGAATCCCTGTTCCCACTGATTTTTATTAGCAAAACATCCTGTGTCTTTTGGAGTACGATG

>80049_80049_10_SEC23A-PSMC1_SEC23A_chr14_39565101_ENST00000557280_PSMC1_chr14_90738616_ENST00000543772_length(amino acids)=81AA_BP=

--------------------------------------------------------------
>80049_80049_11_SEC23A-PSMC1_SEC23A_chr14_39565102_ENST00000307712_PSMC1_chr14_90738617_ENST00000261303_length(transcript)=1089nt_BP=739nt
ACGCTGTGGCTTTAGGGAGCTGGGAAAGGCGCTCTCTCCCGGTCCCGCTCTGCCCGGTCCCACGCCCCTCGGCCGTCCGGCTGCCTGGGT
CTTCCGGGTTCTTCCGCCCCTCTGGCTCGGTCCCCGCTACCTCTCCTCCCTCCTCCCCTCTCGGTACCTTCGCCCGCCGCGCGCCTTTCT
CAAATCCTCCGGTTATTAAGCAAGCTCAGGGGTCCGGTGGCCTGCCCTGGTAACTCTGCGCCCGCCCCTTCCTGCCCCCTTCCTGCCCTC
ACGCCCCGTCCCCTCCTCTTGACGTGGCAGAGGCGGCGCCAGCCATGTTGGCCGGGCGGAGGTCTTCGCTGAGGCCCGGGGCGGGGTGGC
GCCACCCCTGATTGCGGTGCCACGGACTGCTCCTGCTGGGCGGAGAGGACAGATTTTGCAAAGCGGAGGCTGCGACGGGTCCTGCAGGGG
GACAGTGAGGAAAGGGCCGCCTCGTCTCCGCTCCTGGGGGACCGCAGAAATAAGAATCAAACTCCACAATGACAACCTATTTGGAATTCA
TTCAACAAAATGAAGAACGAGATGGAGTCCGATTTAGTTGGAATGTTTGGCCATCAAGTCGACTGGAAGCTACAAGAATGGTTGTTCCTG
TGGCAGCCCTGTTTACACCACTGAAAGAGAGACCTGACTTACCACCTATTCAATATGAACCTGTTCTGTGTAGTAGGACCACTTGCCGTG
CAGTTTTGAATCCTTTATGGCAATCTGTACAGAAGCTGGTCTGATGGCCTTAAGAGAACGTAGAATGAAAGTAACAAATGAAGACTTCAA
AAAATCTAAAGAAAATGTTCTTTATAAGAAACAGGAAGGCACCCCTGAGGGGCTGTATCTCTAATGAACCATGGCTGTCATCAGGAAAAT
GGTTGGGAGATTTCTCAATCCCTGAAAGGGATGAGGTTGGGGGAGTTGCCCAGAGGAATCCCTGTTCCCACTGATTTTTATTAGCAAAAC
ATCCTGTGTCTTTTGGAGTACGATGTGTAAGTGCCCATTGGGTGGCCTGTTGGTCACTGTGCAGCAGTCTGCTTCCCAATAAAGCGTGCT

>80049_80049_11_SEC23A-PSMC1_SEC23A_chr14_39565102_ENST00000307712_PSMC1_chr14_90738617_ENST00000261303_length(amino acids)=109AA_BP=
MSLWSLILISAVPQERRRGGPFLTVPLQDPSQPPLCKICPLRPAGAVRGTAIRGGATPPRASAKTSARPTWLAPPLPRQEEGTGREGRKG

--------------------------------------------------------------
>80049_80049_12_SEC23A-PSMC1_SEC23A_chr14_39565102_ENST00000307712_PSMC1_chr14_90738617_ENST00000543772_length(transcript)=1017nt_BP=739nt
ACGCTGTGGCTTTAGGGAGCTGGGAAAGGCGCTCTCTCCCGGTCCCGCTCTGCCCGGTCCCACGCCCCTCGGCCGTCCGGCTGCCTGGGT
CTTCCGGGTTCTTCCGCCCCTCTGGCTCGGTCCCCGCTACCTCTCCTCCCTCCTCCCCTCTCGGTACCTTCGCCCGCCGCGCGCCTTTCT
CAAATCCTCCGGTTATTAAGCAAGCTCAGGGGTCCGGTGGCCTGCCCTGGTAACTCTGCGCCCGCCCCTTCCTGCCCCCTTCCTGCCCTC
ACGCCCCGTCCCCTCCTCTTGACGTGGCAGAGGCGGCGCCAGCCATGTTGGCCGGGCGGAGGTCTTCGCTGAGGCCCGGGGCGGGGTGGC
GCCACCCCTGATTGCGGTGCCACGGACTGCTCCTGCTGGGCGGAGAGGACAGATTTTGCAAAGCGGAGGCTGCGACGGGTCCTGCAGGGG
GACAGTGAGGAAAGGGCCGCCTCGTCTCCGCTCCTGGGGGACCGCAGAAATAAGAATCAAACTCCACAATGACAACCTATTTGGAATTCA
TTCAACAAAATGAAGAACGAGATGGAGTCCGATTTAGTTGGAATGTTTGGCCATCAAGTCGACTGGAAGCTACAAGAATGGTTGTTCCTG
TGGCAGCCCTGTTTACACCACTGAAAGAGAGACCTGACTTACCACCTATTCAATATGAACCTGTTCTGTGTAGTAGGACCACTTGCCGTG
CAGTTTTGAATCCTTTATGGCAATCTGTACAGAAGCTGGTCTGATGGCCTTAAGAGAACGTAGAATGAAAGTAACAAATGAAGACTTCAA
AAAATCTAAAGAAAATGTTCTTTATAAGAAACAGGAAGGCACCCCTGAGGGGCTGTATCTCTAATGAACCATGGCTGTCATCAGGAAAAT
GGTTGGGAGATTTCTCAATCCCTGAAAGGGATGAGGTTGGGGGAGTTGCCCAGAGGAATCCCTGTTCCCACTGATTTTTATTAGCAAAAC

>80049_80049_12_SEC23A-PSMC1_SEC23A_chr14_39565102_ENST00000307712_PSMC1_chr14_90738617_ENST00000543772_length(amino acids)=109AA_BP=
MSLWSLILISAVPQERRRGGPFLTVPLQDPSQPPLCKICPLRPAGAVRGTAIRGGATPPRASAKTSARPTWLAPPLPRQEEGTGREGRKG

--------------------------------------------------------------
>80049_80049_13_SEC23A-PSMC1_SEC23A_chr14_39565102_ENST00000545328_PSMC1_chr14_90738617_ENST00000261303_length(transcript)=796nt_BP=446nt
GTGGCAGAGGCGGCGCCAGCCATGTTGGCCGGGCGGAGGTCTTCGCTGAGGCCCGGGGCGGGGTGGCGCCACCCCTGATTGCGGTGCCAC
GGACTGCTCCTGCTGGGCGGAGAGGACAGATTTTGCAAAGCGGAGGCTGCGACGGGTCCTGCAGGGGGACAGTGAGGAAAGGGCCGCCTC
GTCTCCGCTCCTGGGGGACCGCAGAAATAAGAATCAAACTCCACAATGACAACCTATTTGGAATTCATTCAACAAAATGAAGAACGAGAT
GGAGTCCGATTTAGTTGGAATGTTTGGCCATCAAGTCGACTGGAAGCTACAAGAATGGTTGTTCCTGTGGCAGCCCTGTTTACACCACTG
AAAGAGAGACCTGACTTACCACCTATTCAATATGAACCTGTTCTGTGTAGTAGGACCACTTGCCGTGCAGTTTTGAATCCTTTATGGCAA
TCTGTACAGAAGCTGGTCTGATGGCCTTAAGAGAACGTAGAATGAAAGTAACAAATGAAGACTTCAAAAAATCTAAAGAAAATGTTCTTT
ATAAGAAACAGGAAGGCACCCCTGAGGGGCTGTATCTCTAATGAACCATGGCTGTCATCAGGAAAATGGTTGGGAGATTTCTCAATCCCT
GAAAGGGATGAGGTTGGGGGAGTTGCCCAGAGGAATCCCTGTTCCCACTGATTTTTATTAGCAAAACATCCTGTGTCTTTTGGAGTACGA

>80049_80049_13_SEC23A-PSMC1_SEC23A_chr14_39565102_ENST00000545328_PSMC1_chr14_90738617_ENST00000261303_length(amino acids)=99AA_BP=
MGSRLLHSDQQATQWALTHRTPKDTGCFANKNQWEQGFLWATPPTSSLSGIEKSPNHFPDDSHGSLEIQPLRGAFLFLIKNIFFRFFEVF

--------------------------------------------------------------
>80049_80049_14_SEC23A-PSMC1_SEC23A_chr14_39565102_ENST00000545328_PSMC1_chr14_90738617_ENST00000543772_length(transcript)=724nt_BP=446nt
GTGGCAGAGGCGGCGCCAGCCATGTTGGCCGGGCGGAGGTCTTCGCTGAGGCCCGGGGCGGGGTGGCGCCACCCCTGATTGCGGTGCCAC
GGACTGCTCCTGCTGGGCGGAGAGGACAGATTTTGCAAAGCGGAGGCTGCGACGGGTCCTGCAGGGGGACAGTGAGGAAAGGGCCGCCTC
GTCTCCGCTCCTGGGGGACCGCAGAAATAAGAATCAAACTCCACAATGACAACCTATTTGGAATTCATTCAACAAAATGAAGAACGAGAT
GGAGTCCGATTTAGTTGGAATGTTTGGCCATCAAGTCGACTGGAAGCTACAAGAATGGTTGTTCCTGTGGCAGCCCTGTTTACACCACTG
AAAGAGAGACCTGACTTACCACCTATTCAATATGAACCTGTTCTGTGTAGTAGGACCACTTGCCGTGCAGTTTTGAATCCTTTATGGCAA
TCTGTACAGAAGCTGGTCTGATGGCCTTAAGAGAACGTAGAATGAAAGTAACAAATGAAGACTTCAAAAAATCTAAAGAAAATGTTCTTT
ATAAGAAACAGGAAGGCACCCCTGAGGGGCTGTATCTCTAATGAACCATGGCTGTCATCAGGAAAATGGTTGGGAGATTTCTCAATCCCT
GAAAGGGATGAGGTTGGGGGAGTTGCCCAGAGGAATCCCTGTTCCCACTGATTTTTATTAGCAAAACATCCTGTGTCTTTTGGAGTACGA

>80049_80049_14_SEC23A-PSMC1_SEC23A_chr14_39565102_ENST00000545328_PSMC1_chr14_90738617_ENST00000543772_length(amino acids)=81AA_BP=

--------------------------------------------------------------
>80049_80049_15_SEC23A-PSMC1_SEC23A_chr14_39565102_ENST00000548032_PSMC1_chr14_90738617_ENST00000261303_length(transcript)=773nt_BP=423nt
GTTGGCCGGGCGGAGGTCTTCGCTGAGGCCCGGGGCGGGGTGGCGCCACCCCTGATTGCGGTGCCACGGACTGCTCCTGCTGGGCGGAGA
GGACAGATTTTGCAAAGCGGAGGCTGCGACGGGTCCTGCAGGGGGACAGTGAGGAAAGGGCCGCCTCGTCTCCGCTCCTGGGGGACCGCA
GAAATAAGAATCAAACTCCACAATGACAACCTATTTGGAATTCATTCAACAAAATGAAGAACGAGATGGAGTCCGATTTAGTTGGAATGT
TTGGCCATCAAGTCGACTGGAAGCTACAAGAATGGTTGTTCCTGTGGCAGCCCTGTTTACACCACTGAAAGAGAGACCTGACTTACCACC
TATTCAATATGAACCTGTTCTGTGTAGTAGGACCACTTGCCGTGCAGTTTTGAATCCTTTATGGCAATCTGTACAGAAGCTGGTCTGATG
GCCTTAAGAGAACGTAGAATGAAAGTAACAAATGAAGACTTCAAAAAATCTAAAGAAAATGTTCTTTATAAGAAACAGGAAGGCACCCCT
GAGGGGCTGTATCTCTAATGAACCATGGCTGTCATCAGGAAAATGGTTGGGAGATTTCTCAATCCCTGAAAGGGATGAGGTTGGGGGAGT
TGCCCAGAGGAATCCCTGTTCCCACTGATTTTTATTAGCAAAACATCCTGTGTCTTTTGGAGTACGATGTGTAAGTGCCCATTGGGTGGC

>80049_80049_15_SEC23A-PSMC1_SEC23A_chr14_39565102_ENST00000548032_PSMC1_chr14_90738617_ENST00000261303_length(amino acids)=99AA_BP=
MGSRLLHSDQQATQWALTHRTPKDTGCFANKNQWEQGFLWATPPTSSLSGIEKSPNHFPDDSHGSLEIQPLRGAFLFLIKNIFFRFFEVF

--------------------------------------------------------------
>80049_80049_16_SEC23A-PSMC1_SEC23A_chr14_39565102_ENST00000548032_PSMC1_chr14_90738617_ENST00000543772_length(transcript)=701nt_BP=423nt
GTTGGCCGGGCGGAGGTCTTCGCTGAGGCCCGGGGCGGGGTGGCGCCACCCCTGATTGCGGTGCCACGGACTGCTCCTGCTGGGCGGAGA
GGACAGATTTTGCAAAGCGGAGGCTGCGACGGGTCCTGCAGGGGGACAGTGAGGAAAGGGCCGCCTCGTCTCCGCTCCTGGGGGACCGCA
GAAATAAGAATCAAACTCCACAATGACAACCTATTTGGAATTCATTCAACAAAATGAAGAACGAGATGGAGTCCGATTTAGTTGGAATGT
TTGGCCATCAAGTCGACTGGAAGCTACAAGAATGGTTGTTCCTGTGGCAGCCCTGTTTACACCACTGAAAGAGAGACCTGACTTACCACC
TATTCAATATGAACCTGTTCTGTGTAGTAGGACCACTTGCCGTGCAGTTTTGAATCCTTTATGGCAATCTGTACAGAAGCTGGTCTGATG
GCCTTAAGAGAACGTAGAATGAAAGTAACAAATGAAGACTTCAAAAAATCTAAAGAAAATGTTCTTTATAAGAAACAGGAAGGCACCCCT
GAGGGGCTGTATCTCTAATGAACCATGGCTGTCATCAGGAAAATGGTTGGGAGATTTCTCAATCCCTGAAAGGGATGAGGTTGGGGGAGT

>80049_80049_16_SEC23A-PSMC1_SEC23A_chr14_39565102_ENST00000548032_PSMC1_chr14_90738617_ENST00000543772_length(amino acids)=81AA_BP=

--------------------------------------------------------------
>80049_80049_17_SEC23A-PSMC1_SEC23A_chr14_39565102_ENST00000553970_PSMC1_chr14_90738617_ENST00000261303_length(transcript)=804nt_BP=454nt
CTCTTGACGTGGCAGAGGCGGCGCCAGCCATGTTGGCCGGGCGGAGGTCTTCGCTGAGGCCCGGGGCGGGGTGGCGCCACCCCTGATTGC
GGTGCCACGGACTGCTCCTGCTGGGCGGAGAGGACAGATTTTGCAAAGCGGAGGCTGCGACGGGTCCTGCAGGGGGACAGTGAGGAAAGG
GCCGCCTCGTCTCCGCTCCTGGGGGACCGCAGAAATAAGAATCAAACTCCACAATGACAACCTATTTGGAATTCATTCAACAAAATGAAG
AACGAGATGGAGTCCGATTTAGTTGGAATGTTTGGCCATCAAGTCGACTGGAAGCTACAAGAATGGTTGTTCCTGTGGCAGCCCTGTTTA
CACCACTGAAAGAGAGACCTGACTTACCACCTATTCAATATGAACCTGTTCTGTGTAGTAGGACCACTTGCCGTGCAGTTTTGAATCCTT
TATGGCAATCTGTACAGAAGCTGGTCTGATGGCCTTAAGAGAACGTAGAATGAAAGTAACAAATGAAGACTTCAAAAAATCTAAAGAAAA
TGTTCTTTATAAGAAACAGGAAGGCACCCCTGAGGGGCTGTATCTCTAATGAACCATGGCTGTCATCAGGAAAATGGTTGGGAGATTTCT
CAATCCCTGAAAGGGATGAGGTTGGGGGAGTTGCCCAGAGGAATCCCTGTTCCCACTGATTTTTATTAGCAAAACATCCTGTGTCTTTTG

>80049_80049_17_SEC23A-PSMC1_SEC23A_chr14_39565102_ENST00000553970_PSMC1_chr14_90738617_ENST00000261303_length(amino acids)=99AA_BP=
MGSRLLHSDQQATQWALTHRTPKDTGCFANKNQWEQGFLWATPPTSSLSGIEKSPNHFPDDSHGSLEIQPLRGAFLFLIKNIFFRFFEVF

--------------------------------------------------------------
>80049_80049_18_SEC23A-PSMC1_SEC23A_chr14_39565102_ENST00000553970_PSMC1_chr14_90738617_ENST00000543772_length(transcript)=732nt_BP=454nt
CTCTTGACGTGGCAGAGGCGGCGCCAGCCATGTTGGCCGGGCGGAGGTCTTCGCTGAGGCCCGGGGCGGGGTGGCGCCACCCCTGATTGC
GGTGCCACGGACTGCTCCTGCTGGGCGGAGAGGACAGATTTTGCAAAGCGGAGGCTGCGACGGGTCCTGCAGGGGGACAGTGAGGAAAGG
GCCGCCTCGTCTCCGCTCCTGGGGGACCGCAGAAATAAGAATCAAACTCCACAATGACAACCTATTTGGAATTCATTCAACAAAATGAAG
AACGAGATGGAGTCCGATTTAGTTGGAATGTTTGGCCATCAAGTCGACTGGAAGCTACAAGAATGGTTGTTCCTGTGGCAGCCCTGTTTA
CACCACTGAAAGAGAGACCTGACTTACCACCTATTCAATATGAACCTGTTCTGTGTAGTAGGACCACTTGCCGTGCAGTTTTGAATCCTT
TATGGCAATCTGTACAGAAGCTGGTCTGATGGCCTTAAGAGAACGTAGAATGAAAGTAACAAATGAAGACTTCAAAAAATCTAAAGAAAA
TGTTCTTTATAAGAAACAGGAAGGCACCCCTGAGGGGCTGTATCTCTAATGAACCATGGCTGTCATCAGGAAAATGGTTGGGAGATTTCT
CAATCCCTGAAAGGGATGAGGTTGGGGGAGTTGCCCAGAGGAATCCCTGTTCCCACTGATTTTTATTAGCAAAACATCCTGTGTCTTTTG

>80049_80049_18_SEC23A-PSMC1_SEC23A_chr14_39565102_ENST00000553970_PSMC1_chr14_90738617_ENST00000543772_length(amino acids)=81AA_BP=

--------------------------------------------------------------
>80049_80049_19_SEC23A-PSMC1_SEC23A_chr14_39565102_ENST00000557280_PSMC1_chr14_90738617_ENST00000261303_length(transcript)=794nt_BP=444nt
GGCAGAGGCGGCGCCAGCCATGTTGGCCGGGCGGAGGTCTTCGCTGAGGCCCGGGGCGGGGTGGCGCCACCCCTGATTGCGGTGCCACGG
ACTGCTCCTGCTGGGCGGAGAGGACAGATTTTGCAAAGCGGAGGCTGCGACGGGTCCTGCAGGGGGACAGTGAGGAAAGGGCCGCCTCGT
CTCCGCTCCTGGGGGACCGCAGAAATAAGAATCAAACTCCACAATGACAACCTATTTGGAATTCATTCAACAAAATGAAGAACGAGATGG
AGTCCGATTTAGTTGGAATGTTTGGCCATCAAGTCGACTGGAAGCTACAAGAATGGTTGTTCCTGTGGCAGCCCTGTTTACACCACTGAA
AGAGAGACCTGACTTACCACCTATTCAATATGAACCTGTTCTGTGTAGTAGGACCACTTGCCGTGCAGTTTTGAATCCTTTATGGCAATC
TGTACAGAAGCTGGTCTGATGGCCTTAAGAGAACGTAGAATGAAAGTAACAAATGAAGACTTCAAAAAATCTAAAGAAAATGTTCTTTAT
AAGAAACAGGAAGGCACCCCTGAGGGGCTGTATCTCTAATGAACCATGGCTGTCATCAGGAAAATGGTTGGGAGATTTCTCAATCCCTGA
AAGGGATGAGGTTGGGGGAGTTGCCCAGAGGAATCCCTGTTCCCACTGATTTTTATTAGCAAAACATCCTGTGTCTTTTGGAGTACGATG

>80049_80049_19_SEC23A-PSMC1_SEC23A_chr14_39565102_ENST00000557280_PSMC1_chr14_90738617_ENST00000261303_length(amino acids)=99AA_BP=
MGSRLLHSDQQATQWALTHRTPKDTGCFANKNQWEQGFLWATPPTSSLSGIEKSPNHFPDDSHGSLEIQPLRGAFLFLIKNIFFRFFEVF

--------------------------------------------------------------
>80049_80049_20_SEC23A-PSMC1_SEC23A_chr14_39565102_ENST00000557280_PSMC1_chr14_90738617_ENST00000543772_length(transcript)=722nt_BP=444nt
GGCAGAGGCGGCGCCAGCCATGTTGGCCGGGCGGAGGTCTTCGCTGAGGCCCGGGGCGGGGTGGCGCCACCCCTGATTGCGGTGCCACGG
ACTGCTCCTGCTGGGCGGAGAGGACAGATTTTGCAAAGCGGAGGCTGCGACGGGTCCTGCAGGGGGACAGTGAGGAAAGGGCCGCCTCGT
CTCCGCTCCTGGGGGACCGCAGAAATAAGAATCAAACTCCACAATGACAACCTATTTGGAATTCATTCAACAAAATGAAGAACGAGATGG
AGTCCGATTTAGTTGGAATGTTTGGCCATCAAGTCGACTGGAAGCTACAAGAATGGTTGTTCCTGTGGCAGCCCTGTTTACACCACTGAA
AGAGAGACCTGACTTACCACCTATTCAATATGAACCTGTTCTGTGTAGTAGGACCACTTGCCGTGCAGTTTTGAATCCTTTATGGCAATC
TGTACAGAAGCTGGTCTGATGGCCTTAAGAGAACGTAGAATGAAAGTAACAAATGAAGACTTCAAAAAATCTAAAGAAAATGTTCTTTAT
AAGAAACAGGAAGGCACCCCTGAGGGGCTGTATCTCTAATGAACCATGGCTGTCATCAGGAAAATGGTTGGGAGATTTCTCAATCCCTGA
AAGGGATGAGGTTGGGGGAGTTGCCCAGAGGAATCCCTGTTCCCACTGATTTTTATTAGCAAAACATCCTGTGTCTTTTGGAGTACGATG

>80049_80049_20_SEC23A-PSMC1_SEC23A_chr14_39565102_ENST00000557280_PSMC1_chr14_90738617_ENST00000543772_length(amino acids)=81AA_BP=

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Fusion Gene PPI Analysis for SEC23A-PSMC1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for SEC23A-PSMC1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for SEC23A-PSMC1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource