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 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:SEC24A-DDX46 (FusionGDB2 ID:80075) |
Fusion Gene Summary for SEC24A-DDX46 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: SEC24A-DDX46 | Fusion gene ID: 80075 | Hgene | Tgene | Gene symbol | SEC24A | DDX46 | Gene ID | 10802 | 9879 |
| Gene name | SEC24 homolog A, COPII coat complex component | DEAD-box helicase 46 | |
| Synonyms | - | PRPF5|Prp5 | |
| Cytomap | 5q31.1 | 5q31.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | protein transport protein Sec24ASEC24 family, member ASEC24 related gene family, member ASEC24-related protein A | probable ATP-dependent RNA helicase DDX46DEAD (Asp-Glu-Ala-Asp) box polypeptide 46DEAD box protein 46PRP5 homologPrp5-like DEAD-box proteinRNA helicase | |
| Modification date | 20200327 | 20200313 | |
| UniProtAcc | . | Q7L014 | |
| Ensembl transtripts involved in fusion gene | ENST00000322887, ENST00000398844, | ENST00000509178, ENST00000354283, ENST00000452510, | |
| Fusion gene scores | * DoF score | 8 X 6 X 8=384 | 11 X 9 X 6=594 |
| # samples | 9 | 12 | |
| ** MAII score | log2(9/384*10)=-2.09310940439148 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(12/594*10)=-2.30742852519225 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: SEC24A [Title/Abstract] AND DDX46 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | DDX46(134126242)-SEC24A(134010305), # samples:3 SEC24A(134002686)-DDX46(134113264), # samples:2 | ||
| Anticipated loss of major functional domain due to fusion event. | DDX46-SEC24A seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | SEC24A | GO:0090110 | cargo loading into COPII-coated vesicle | 17499046|18843296 |
| Fusion gene breakpoints across SEC24A (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene breakpoints across DDX46 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | LUAD | TCGA-78-7155-01A | SEC24A | chr5 | 134002686 | + | DDX46 | chr5 | 134113264 | + |
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Fusion Gene ORF analysis for SEC24A-DDX46 |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-intron | ENST00000322887 | ENST00000509178 | SEC24A | chr5 | 134002686 | + | DDX46 | chr5 | 134113264 | + |
| 5CDS-intron | ENST00000398844 | ENST00000509178 | SEC24A | chr5 | 134002686 | + | DDX46 | chr5 | 134113264 | + |
| In-frame | ENST00000322887 | ENST00000354283 | SEC24A | chr5 | 134002686 | + | DDX46 | chr5 | 134113264 | + |
| In-frame | ENST00000322887 | ENST00000452510 | SEC24A | chr5 | 134002686 | + | DDX46 | chr5 | 134113264 | + |
| In-frame | ENST00000398844 | ENST00000354283 | SEC24A | chr5 | 134002686 | + | DDX46 | chr5 | 134113264 | + |
| In-frame | ENST00000398844 | ENST00000452510 | SEC24A | chr5 | 134002686 | + | DDX46 | chr5 | 134113264 | + |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000398844 | SEC24A | chr5 | 134002686 | + | ENST00000452510 | DDX46 | chr5 | 134113264 | + | 5945 | 1027 | 288 | 3512 | 1074 |
| ENST00000398844 | SEC24A | chr5 | 134002686 | + | ENST00000354283 | DDX46 | chr5 | 134113264 | + | 4100 | 1027 | 288 | 3509 | 1073 |
| ENST00000322887 | SEC24A | chr5 | 134002686 | + | ENST00000452510 | DDX46 | chr5 | 134113264 | + | 5910 | 992 | 253 | 3477 | 1074 |
| ENST00000322887 | SEC24A | chr5 | 134002686 | + | ENST00000354283 | DDX46 | chr5 | 134113264 | + | 4065 | 992 | 253 | 3474 | 1073 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000398844 | ENST00000452510 | SEC24A | chr5 | 134002686 | + | DDX46 | chr5 | 134113264 | + | 0.000269683 | 0.9997303 |
| ENST00000398844 | ENST00000354283 | SEC24A | chr5 | 134002686 | + | DDX46 | chr5 | 134113264 | + | 0.000647359 | 0.99935263 |
| ENST00000322887 | ENST00000452510 | SEC24A | chr5 | 134002686 | + | DDX46 | chr5 | 134113264 | + | 0.000257456 | 0.99974257 |
| ENST00000322887 | ENST00000354283 | SEC24A | chr5 | 134002686 | + | DDX46 | chr5 | 134113264 | + | 0.000615477 | 0.9993845 |
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Fusion Genomic Features for SEC24A-DDX46 |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| SEC24A | chr5 | 134002686 | + | DDX46 | chr5 | 134113263 | + | 1.31E-13 | 1 |
| SEC24A | chr5 | 134002686 | + | DDX46 | chr5 | 134113263 | + | 1.31E-13 | 1 |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
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| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for SEC24A-DDX46 |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr5:134126242/chr5:134010305) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| . | DDX46 |
| FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. | FUNCTION: Plays an essential role in splicing, either prior to, or during splicing A complex formation. {ECO:0000269|PubMed:12234937}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | SEC24A | chr5:134002686 | chr5:134113264 | ENST00000322887 | + | 3 | 13 | 89_237 | 246 | 614.0 | Compositional bias | Note=Pro-rich |
| Hgene | SEC24A | chr5:134002686 | chr5:134113264 | ENST00000398844 | + | 3 | 23 | 89_237 | 246 | 1094.0 | Compositional bias | Note=Pro-rich |
| Tgene | DDX46 | chr5:134002686 | chr5:134113264 | ENST00000354283 | 4 | 23 | 202_209 | 204 | 1032.0 | Compositional bias | Note=Poly-Asp | |
| Tgene | DDX46 | chr5:134002686 | chr5:134113264 | ENST00000452510 | 4 | 23 | 202_209 | 204 | 1033.0 | Compositional bias | Note=Poly-Asp | |
| Tgene | DDX46 | chr5:134002686 | chr5:134113264 | ENST00000354283 | 4 | 23 | 403_581 | 204 | 1032.0 | Domain | Helicase ATP-binding | |
| Tgene | DDX46 | chr5:134002686 | chr5:134113264 | ENST00000354283 | 4 | 23 | 592_753 | 204 | 1032.0 | Domain | Helicase C-terminal | |
| Tgene | DDX46 | chr5:134002686 | chr5:134113264 | ENST00000452510 | 4 | 23 | 403_581 | 204 | 1033.0 | Domain | Helicase ATP-binding | |
| Tgene | DDX46 | chr5:134002686 | chr5:134113264 | ENST00000452510 | 4 | 23 | 592_753 | 204 | 1033.0 | Domain | Helicase C-terminal | |
| Tgene | DDX46 | chr5:134002686 | chr5:134113264 | ENST00000354283 | 4 | 23 | 372_400 | 204 | 1032.0 | Motif | Note=Q motif | |
| Tgene | DDX46 | chr5:134002686 | chr5:134113264 | ENST00000354283 | 4 | 23 | 529_532 | 204 | 1032.0 | Motif | Note=DEAD box | |
| Tgene | DDX46 | chr5:134002686 | chr5:134113264 | ENST00000452510 | 4 | 23 | 372_400 | 204 | 1033.0 | Motif | Note=Q motif | |
| Tgene | DDX46 | chr5:134002686 | chr5:134113264 | ENST00000452510 | 4 | 23 | 529_532 | 204 | 1033.0 | Motif | Note=DEAD box | |
| Tgene | DDX46 | chr5:134002686 | chr5:134113264 | ENST00000354283 | 4 | 23 | 416_423 | 204 | 1032.0 | Nucleotide binding | ATP | |
| Tgene | DDX46 | chr5:134002686 | chr5:134113264 | ENST00000452510 | 4 | 23 | 416_423 | 204 | 1033.0 | Nucleotide binding | ATP |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | SEC24A | chr5:134002686 | chr5:134113264 | ENST00000322887 | + | 3 | 13 | 431_455 | 246 | 614.0 | Region | Note=Zinc finger-like |
| Hgene | SEC24A | chr5:134002686 | chr5:134113264 | ENST00000398844 | + | 3 | 23 | 431_455 | 246 | 1094.0 | Region | Note=Zinc finger-like |
| Hgene | SEC24A | chr5:134002686 | chr5:134113264 | ENST00000322887 | + | 3 | 13 | 966_1038 | 246 | 614.0 | Repeat | Gelsolin-like |
| Hgene | SEC24A | chr5:134002686 | chr5:134113264 | ENST00000398844 | + | 3 | 23 | 966_1038 | 246 | 1094.0 | Repeat | Gelsolin-like |
| Tgene | DDX46 | chr5:134002686 | chr5:134113264 | ENST00000354283 | 4 | 23 | 152_197 | 204 | 1032.0 | Coiled coil | Ontology_term=ECO:0000255 | |
| Tgene | DDX46 | chr5:134002686 | chr5:134113264 | ENST00000452510 | 4 | 23 | 152_197 | 204 | 1033.0 | Coiled coil | Ontology_term=ECO:0000255 | |
| Tgene | DDX46 | chr5:134002686 | chr5:134113264 | ENST00000354283 | 4 | 23 | 3_103 | 204 | 1032.0 | Compositional bias | Note=Arg-rich | |
| Tgene | DDX46 | chr5:134002686 | chr5:134113264 | ENST00000452510 | 4 | 23 | 3_103 | 204 | 1033.0 | Compositional bias | Note=Arg-rich |
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Fusion Gene Sequence for SEC24A-DDX46 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >80075_80075_1_SEC24A-DDX46_SEC24A_chr5_134002686_ENST00000322887_DDX46_chr5_134113264_ENST00000354283_length(transcript)=4065nt_BP=992nt CTGCCGCCTTCTAGCCGGGCGTTCGCGGCCCCGCCGGCCCGACTCTCAAGCCTCAGCTCCCAGGCTAGGCTGTGGCCGCCGGTGGCCTGG GGAGAGTGCGGCGCCATGCCTCGGGCTTAATGCGCCCCCCCCTCTTCTCCCAGTCTTCAGTCTTAAGTCGTTAGCCTCCTCCCTCCGCTT TCAGCAGTGGTCTTTCAGCTCTCTTCTTGTGCGCTGTTGTCGACCCCGACCAGCCCCTTCCAACCCAGTCATCATGTCCCAGCCGGGAAT ACCGGCCTCCGGCGGCGCCCCAGCCAGCCTCCAGGCCCAGAACGGAGCCGCCTTGGCCTCGGGGTCTCCCTACACCAACGGTCCTGTCCA AAATGCATTGCTGTCTTCACAAGAGTCAGTGAGCCAAGGATACAATTTCCAGCTTCCAGGATCCTACCCTCATCCAATACCAGCAAAGAC TTTGAATCCAGTCTCTGGACAGTCTAACTATGGTGGTTCTCAGGGATCTGGGCAGACTCTTAATAGACCACCTGTGGCCTCTAATCCAGT GACACCTTCGCTTCATAGTGGTCCTGCTCCCCGAATGCCATTACCTGCTTCTCAGAACCCAGCTACTACACCAATGCCTTCTAGTAGCTT TCTTCCTGAAGCCAACCTGCCACCACCTTTGAATTGGCAATATAACTATCCATCCACAGCCTCACAAACAAACCATTGTCCTCGTGCATC ATCCCAACCAACTGTATCTGGAAATACAAGTTTAACCACAAATCATCAATATGTTTCTTCTGGATATCCTTCACTTCAAAATAGCTTCAT AAAGTCAGGTCCTTCTGTACCTCCCTTAGTGAATCCACCTCTGCCTACAACTTTTCAACCAGGAGCTCCTCATGGGCCCCCTCCAGCTGG AGGCCCACCCCCAGTGAGGGCCCTCACGCCCCTGACATCATCATATAGAGATGTACCCCAGCCCTTATTTAATTCAGCTGTCAACCAAGA AGATGACGAAGATGATCCTGCAGAAGCTGAAAAGGAGGGAAATGAAATGGAGGGTGAGGAGTTAGATCCATTAGATGCTTACATGGAAGA AGTGAAAGAGGAAGTAAAAAAATTTAACATGAGAAGTGTAAAAGGTGGTGGGGGAAATGAAAAGAAGTCTGGGCCAACGGTCACAAAAGT TGTCACTGTTGTGACAACCAAAAAAGCAGTTGTGGATTCTGATAAGAAGAAAGGTGAGCTGATGGAGAATGACCAGGATGCCATGGAGTA TTCTTCAGAGGAGGAAGAAGTTGATCTTCAGACAGCCCTTACAGGGTATCAAACAAAACAGCGAAAGCTTCTAGAACCAGTTGATCATGG AAAAATTGAGTATGAGCCATTTAGGAAAAACTTCTATGTTGAAGTTCCAGAACTAGCAAAAATGTCTCAAGAAGAGGTAAATGTGTTTCG ATTGGAAATGGAGGGCATTACAGTTAAAGGAAAAGGTTGCCCCAAACCAATTAAATCCTGGGTCCAGTGTGGAATTTCCATGAAGATCTT AAATTCCCTCAAGAAGCATGGCTATGAAAAGCCCACGCCCATCCAAACCCAAGCTATTCCTGCTATAATGTCTGGACGAGATTTGATTGG CATTGCCAAAACAGGAAGTGGAAAGACCATTGCTTTTCTGTTGCCCATGTTTAGACACATCATGGATCAGAGGTCATTAGAGGAAGGAGA GGGGCCAATAGCTGTCATCATGACTCCAACTCGAGAACTGGCTTTACAGATTACTAAAGAGTGTAAGAAGTTTTCCAAGACTTTGGGACT TAGAGTGGTCTGTGTTTACGGAGGAACAGGAATCAGTGAGCAGATTGCTGAGCTGAAAAGAGGTGCTGAAATTATTGTTTGCACACCTGG TCGAATGATTGACATGTTAGCCGCTAACAGTGGTCGGGTCACAAATCTTCGAAGAGTGACATATGTTGTTTTAGATGAAGCAGACAGAAT GTTTGACATGGGTTTTGAACCCCAGGTCATGCGCATCGTGGATAATGTTCGTCCTGATCGACAGACGGTTATGTTTTCAGCTACTTTCCC CAGAGCTATGGAGGCTTTGGCTCGCAGGATCCTCAGTAAACCTATTGAAGTACAAGTTGGAGGCAGGAGTGTGGTTTGCTCAGATGTGGA GCAACAAGTGATTGTGATTGAAGAAGAAAAGAAATTCTTGAAGTTACTTGAGCTTCTAGGCCATTATCAAGAGTCAGGATCTGTCATTAT ATTTGTGGATAAGCAGGAACATGCTGATGGTCTTCTTAAGGATTTAATGAGAGCATCTTATCCTTGCATGTCTCTTCATGGAGGCATTGA TCAATATGACAGAGATAGCATCATAAATGACTTTAAGAATGGGACCTGCAAACTTCTTGTGGCTACCTCTGTTGCTGCCCGAGGTCTAGA TGTGAAACATCTGATTCTTGTAGTAAATTATAGCTGCCCCAACCATTATGAGGATTATGTACACAGAGCAGGGCGGACTGGAAGAGCAGG AAACAAGGGTTATGCTTATACTTTTATCACAGAGGATCAAGCTCGCTATGCTGGTGACATAATTAAAGCTCTTGAATTGTCAGGGACTGC AGTACCTCCTGATTTAGAGAAACTGTGGAGTGATTTCAAAGATCAGCAGAAAGCTGAGGGGAAAATAATTAAAAAGAGTAGTGGGTTCTC TGGTAAGGGATTCAAGTTTGATGAAACAGAACAAGCTTTGGCTAATGAGAGGAAGAAGTTACAAAAAGCAGCTCTTGGTCTACAAGATTC AGATGATGAGGATGCTGCAGTTGATATTGATGAGCAAATTGAAAGCATGTTTAATTCAAAGAAGAGAGTAAAGGATATGGCTGCTCCTGG AACATCAAGTGTTCCTGCTCCAACTGCAGGAAATGCTGAGAAATTAGAAATTGCTAAGAGATTGGCTCTTAGAATCAATGCCCAGAAGAA TTTGGGCATCGAGTCTCAGGATGTGATGCAGCAGGCCACCAATGCAATTCTTAGGGGTGGCACCATTCTGGCTCCCACTGTTTCTGCAAA AACCATTGCAGAACAACTTGCTGAAAAGATCAATGCCAAGCTCAATTATGTGCCGTTAGAGAAACAAGAAGAAGAGAGACAGGATGGTGG ACAGAATGAATCTTTTAAGAGATATGAAGAAGAATTAGAGATCAATGACTTCCCACAGACTGCTAGGTGGAAAGTTACCTCTAAGGAAGC TCTGCAGAGAATCAGTGAATACTCTGAAGCCGCAATTACAATCAGAGGAACCTACTTCCCTCCTGGCAAAGAACCCAAGGAAGGCGAGCG GAAGATTTACTTGGCAATTGAAAGTGCCAATGAACTGGCTGTGCAGAAAGCAAAGGCAGAAATCACCAGGCTCATAAAAGAAGAGCTGAT CCGGCTGCAAAATTCATACCAACCAACAAATAAAGGAAGATACAAAGTCTTATAGACATCCGGAAAAAAGATTTTTACCTGTGCTGGTCT ATGATGTATGTGGCAGTTGCTGTCTGCAGTTTACAATGTATTGTAAATGAAGATTTTTTAAATTCTATCTTGCTGATTTTTTTTAAATAT AAGAAACTGGTACTTGGTAAAGAAATCTGTCCGTAAGTACCCCCACAATCAGTCAAACTATATTTAAAGCCAGCCTGTTTTCAGAGTATG ATGTCCTTTAATGTAAACTCAAATATCAATATTTTAAATGTCCGGATAATATTCTAGAGGTTTAAAAAATGGAAATATTTGAACTTTCTA TTGAAGACAATAAAGTACACAAGTCGTTAAGGGGCTATTCACTTTATCCTGTACTTTCAATGAAATTGTGATCATTTCCTAAGAAAAGGT AAAATTCACTATCATATTTTGTGTCCCCACCTTGATGTTACATGACTCTGGAACAATATGAACTGGATTTAAGAATGTTATAATAGAAGT CTTACAAAATGGGTTGAGAGTTTTTGTTTCAATTTTTATCATCATAAATGGGCAAAAAGTAGTTGGACTAATTTCGGTTTTTATACAAGT >80075_80075_1_SEC24A-DDX46_SEC24A_chr5_134002686_ENST00000322887_DDX46_chr5_134113264_ENST00000354283_length(amino acids)=1073AA_BP=0 MSQPGIPASGGAPASLQAQNGAALASGSPYTNGPVQNALLSSQESVSQGYNFQLPGSYPHPIPAKTLNPVSGQSNYGGSQGSGQTLNRPP VASNPVTPSLHSGPAPRMPLPASQNPATTPMPSSSFLPEANLPPPLNWQYNYPSTASQTNHCPRASSQPTVSGNTSLTTNHQYVSSGYPS LQNSFIKSGPSVPPLVNPPLPTTFQPGAPHGPPPAGGPPPVRALTPLTSSYRDVPQPLFNSAVNQEDDEDDPAEAEKEGNEMEGEELDPL DAYMEEVKEEVKKFNMRSVKGGGGNEKKSGPTVTKVVTVVTTKKAVVDSDKKKGELMENDQDAMEYSSEEEEVDLQTALTGYQTKQRKLL EPVDHGKIEYEPFRKNFYVEVPELAKMSQEEVNVFRLEMEGITVKGKGCPKPIKSWVQCGISMKILNSLKKHGYEKPTPIQTQAIPAIMS GRDLIGIAKTGSGKTIAFLLPMFRHIMDQRSLEEGEGPIAVIMTPTRELALQITKECKKFSKTLGLRVVCVYGGTGISEQIAELKRGAEI IVCTPGRMIDMLAANSGRVTNLRRVTYVVLDEADRMFDMGFEPQVMRIVDNVRPDRQTVMFSATFPRAMEALARRILSKPIEVQVGGRSV VCSDVEQQVIVIEEEKKFLKLLELLGHYQESGSVIIFVDKQEHADGLLKDLMRASYPCMSLHGGIDQYDRDSIINDFKNGTCKLLVATSV AARGLDVKHLILVVNYSCPNHYEDYVHRAGRTGRAGNKGYAYTFITEDQARYAGDIIKALELSGTAVPPDLEKLWSDFKDQQKAEGKIIK KSSGFSGKGFKFDETEQALANERKKLQKAALGLQDSDDEDAAVDIDEQIESMFNSKKRVKDMAAPGTSSVPAPTAGNAEKLEIAKRLALR INAQKNLGIESQDVMQQATNAILRGGTILAPTVSAKTIAEQLAEKINAKLNYVPLEKQEEERQDGGQNESFKRYEEELEINDFPQTARWK -------------------------------------------------------------- >80075_80075_2_SEC24A-DDX46_SEC24A_chr5_134002686_ENST00000322887_DDX46_chr5_134113264_ENST00000452510_length(transcript)=5910nt_BP=992nt CTGCCGCCTTCTAGCCGGGCGTTCGCGGCCCCGCCGGCCCGACTCTCAAGCCTCAGCTCCCAGGCTAGGCTGTGGCCGCCGGTGGCCTGG GGAGAGTGCGGCGCCATGCCTCGGGCTTAATGCGCCCCCCCCTCTTCTCCCAGTCTTCAGTCTTAAGTCGTTAGCCTCCTCCCTCCGCTT TCAGCAGTGGTCTTTCAGCTCTCTTCTTGTGCGCTGTTGTCGACCCCGACCAGCCCCTTCCAACCCAGTCATCATGTCCCAGCCGGGAAT ACCGGCCTCCGGCGGCGCCCCAGCCAGCCTCCAGGCCCAGAACGGAGCCGCCTTGGCCTCGGGGTCTCCCTACACCAACGGTCCTGTCCA AAATGCATTGCTGTCTTCACAAGAGTCAGTGAGCCAAGGATACAATTTCCAGCTTCCAGGATCCTACCCTCATCCAATACCAGCAAAGAC TTTGAATCCAGTCTCTGGACAGTCTAACTATGGTGGTTCTCAGGGATCTGGGCAGACTCTTAATAGACCACCTGTGGCCTCTAATCCAGT GACACCTTCGCTTCATAGTGGTCCTGCTCCCCGAATGCCATTACCTGCTTCTCAGAACCCAGCTACTACACCAATGCCTTCTAGTAGCTT TCTTCCTGAAGCCAACCTGCCACCACCTTTGAATTGGCAATATAACTATCCATCCACAGCCTCACAAACAAACCATTGTCCTCGTGCATC ATCCCAACCAACTGTATCTGGAAATACAAGTTTAACCACAAATCATCAATATGTTTCTTCTGGATATCCTTCACTTCAAAATAGCTTCAT AAAGTCAGGTCCTTCTGTACCTCCCTTAGTGAATCCACCTCTGCCTACAACTTTTCAACCAGGAGCTCCTCATGGGCCCCCTCCAGCTGG AGGCCCACCCCCAGTGAGGGCCCTCACGCCCCTGACATCATCATATAGAGATGTACCCCAGCCCTTATTTAATTCAGCTGTCAACCAAGA AGATGACGAAGATGATCCTGCAGAAGCTGAAAAGGAGGGAAATGAAATGGAGGGTGAGGAGTTAGATCCATTAGATGCTTACATGGAAGA AGTGAAAGAGGAAGTAAAAAAATTTAACATGAGAAGTGTAAAAGGTGGTGGGGGAAATGAAAAGAAGTCTGGGCCAACGGTCACAAAAGT TGTCACTGTTGTGACAACCAAAAAAGCAGTTGTGGATTCTGATAAGAAGAAAGGTGAGCTGATGGAGAATGACCAGGATGCCATGGAGTA TTCTTCAGAGGAGGAAGAAGTTGATCTTCAGACAGCCCTTACAGGGTATCAAACAAAACAGCGAAAGCTTCTAGAACCAGTTGATCATGG AAAAATTGAGTATGAGCCATTTAGGAAAAACTTCTATGTTGAAGTTCCAGAACTAGCAAAAATGTCTCAAGAAGAGGTAAATGTGTTTCG ATTGGAAATGGAGGGCATTACAGTTAAAGGAAAAGGTTGCCCCAAACCAATTAAATCCTGGGTCCAGTGTGGAATTTCCATGAAGATCTT AAATTCCCTCAAGAAGCATGGCTATGAAAAGCCCACGCCCATCCAAACCCAAGCTATTCCTGCTATAATGTCTGGACGAGATTTGATTGG CATTGCCAAAACAGGAAGTGGAAAGACCATTGCTTTTCTGTTGCCCATGTTTAGACACATCATGGATCAGAGGTCATTAGAGGAAGGAGA GGGGCCAATAGCTGTCATCATGACTCCAACTCGAGAACTGGCTTTACAGATTACTAAAGAGTGTAAGAAGTTTTCCAAGACTTTGGGACT TAGAGTGGTCTGTGTTTACGGAGGAACAGGAATCAGTGAGCAGATTGCTGAGCTGAAAAGAGGTGCTGAAATTATTGTTTGCACACCTGG TCGAATGATTGACATGTTAGCCGCTAACAGTGGTCGGGTCACAAATCTTCGAAGAGTGACATATGTTGTTTTAGATGAAGCAGACAGAAT GTTTGACATGGGTTTTGAACCCCAGGTCATGCGCATCGTGGATAATGTTCGTCCTGATCGACAGACGGTTATGTTTTCAGCTACTTTCCC CAGAGCTATGGAGGCTTTGGCTCGCAGGATCCTCAGTAAACCTATTGAAGTACAAGTTGGAGGCAGGAGTGTGGTTTGCTCAGATGTGGA GCAACAAGTGATTGTGATTGAAGAAGAAAAGAAATTCTTGAAGTTACTTGAGCTTCTAGGCCATTATCAAGAGTCAGGATCTGTCATTAT ATTTGTGGATAAGCAGGAACATGCTGATGGTCTTCTTAAGGATTTAATGAGAGCATCTTATCCTTGCATGTCTCTTCATGGAGGCATTGA TCAATATGACAGAGATAGCATCATAAATGACTTTAAGAATGGGACCTGCAAACTTCTTGTGGCTACCTCTGTTGCTGCCCGAGGTCTAGA TGTGAAACATCTGATTCTTGTAGTAAATTATAGCTGCCCCAACCATTATGAGGATTATGTACACAGAGCAGGGCGGACTGGAAGAGCAGG AAACAAGGGTTATGCTTATACTTTTATCACAGAGGATCAAGCTCGCTATGCTGGTGACATAATTAAAGCTCTTGAATTGTCAGGGACTGC AGTACCTCCTGATTTAGAGAAACTGTGGAGTGATTTCAAAGATCAGCAGAAAGCTGAGGGGAAAATAATTAAAAAGAGTAGTGGGTTCTC TGGTAAGGGATTCAAGTTTGATGAAACAGAACAAGCTTTGGCTAATGAGAGGAAGAAGTTACAAAAAGCAGCTCTTGGTCTACAAGATTC AGATGATGAGGATGCTGCAGTTGATATTGATGAGCAAATTGAAAGCATGTTTAATTCAAAGAAGAGAGTAAAGGATATGGCTGCTCCTGG AACATCAAGTGTTCCTGCTCCAACTGCAGGAAATGCTGAGAAATTAGAAATTGCTAAGAGATTGGCTCTTAGAATCAATGCCCAGAAGAA TTTGGGCATCGAGTCTCAGGTAGATGTGATGCAGCAGGCCACCAATGCAATTCTTAGGGGTGGCACCATTCTGGCTCCCACTGTTTCTGC AAAAACCATTGCAGAACAACTTGCTGAAAAGATCAATGCCAAGCTCAATTATGTGCCGTTAGAGAAACAAGAAGAAGAGAGACAGGATGG TGGACAGAATGAATCTTTTAAGAGATATGAAGAAGAATTAGAGATCAATGACTTCCCACAGACTGCTAGGTGGAAAGTTACCTCTAAGGA AGCTCTGCAGAGAATCAGTGAATACTCTGAAGCCGCAATTACAATCAGAGGAACCTACTTCCCTCCTGGCAAAGAACCCAAGGAAGGCGA GCGGAAGATTTACTTGGCAATTGAAAGTGCCAATGAACTGGCTGTGCAGAAAGCAAAGGCAGAAATCACCAGGCTCATAAAAGAAGAGCT GATCCGGCTGCAAAATTCATACCAACCAACAAATAAAGGAAGATACAAAGTCTTATAGACATCCGGAAAAAAGATTTTTACCTGTGCTGG TCTATGATGTATGTGGCAGTTGCTGTCTGCAGTTTACAATGTATTGTAAATGAAGATTTTTTAAATTCTATCTTGCTGATTTTTTTTAAA TATAAGAAACTGGTACTTGGTAAAGAAATCTGTCCGTAAGTACCCCCACAATCAGTCAAACTATATTTAAAGCCAGCCTGTTTTCAGAGT ATGATGTCCTTTAATGTAAACTCAAATATCAATATTTTAAATGTCCGGATAATATTCTAGAGGTTTAAAAAATGGAAATATTTGAACTTT CTATTGAAGACAATAAAGTACACAAGTCGTTAAGGGGCTATTCACTTTATCCTGTACTTTCAATGAAATTGTGATCATTTCCTAAGAAAA GGTAAAATTCACTATCATATTTTGTGTCCCCACCTTGATGTTACATGACTCTGGAACAATATGAACTGGATTTAAGAATGTTATAATAGA AGTCTTACAAAATGGGTTGAGAGTTTTTGTTTCAATTTTTATCATCATAAATGGGCAAAAAGTAGTTGGACTAATTTCGGTTTTTATACA AGTAAAGATTTAATAGTATAAGGATTTTTTTGCATTTCTTTACACTGAGTGTAAAACTCTACAAAGAGTTATAGTATTTACTACTTTGAG GTTTCCCTCACAACTTCTGGCTCCATACCTAGCCCCTCTTTTATAATCTTCCTTAAAAGAAAGAGTGTAGCCTATAAATACTAAATATGA TACCTTTTCCTTCTAGAAAGTGTTTATTTATATATCTATACATGTTGTATGTACAAATATCCTACTACTTTTAATCTGATTTTTCTTCAG GATTATTGAGTAGGTTGTGAATTTTCTTTCTTAAAAATTGTAAAACATAATGGTACCCAAGTTTTAAACTTAGATGTGCTTCATCTTAGT GAAATTTAATTCACAAGGAATCATAAATTGTGTTTTTGAGGCTGGGCGCAGTGACTCACACCTGTATCCCAGCAATTTGGGAGGCCGAGG TGGGCAGATCACTTGAGGTCAGGAGTTCAAGACTAGCCTGGTCAACATGGTGAAACCCTGTCTCTACTAAAAATACAAAAATTAGTCGGC ATGGTGGTGGGTGGCTGTAATCCCAGCTACTCAGGAGGCTGAGGCAGAAGAATCTGAGCCAAGATAACACCATTGCACTCCAGCCTGGGC GACAGAGTGAGACTATCTCAAAAATAAATAAATAAATAAATAAATAGTATTTTTGAGCCTTCAAGATACAGTTCCTGAATATTCTAATTT AAATTGTTATAATTGGATTACCTAATATTCTTTTCAAGACTCCTGATGTATTAACTTCATGTTATTGTCACTTTTCAAAAAAGGAATTTT TTTCAGGAGTTAAATAAAGTCAGTCTTTTATATCCAAGGGTTTCAAACCCACAGATTAAACCAACCACAGATCAAAAATAGAAAAAAAAA AAAAAAGAAAAAAAGAATGTAAAATTTTAAAAATACAGTTTAACAGCTGTAAAAGTTTTACTATAACATTTACATTGTGTTAGGTATTTT AAGTAATTTAAAGGTTACAGTATACAGGCGGTTAAAGTATACAGGAGGATGTGCATCGGTTATATGCATATAGCAAGCCATTTCATATAA GAGGCTTGAACATCCATGGATTTTGGTATAGAGGAGGGGTTTAAGGGGTGTCCTGCAATCAGTCCCCCTCTCATACCAAAGGATGACTGT ATATTTCTTAAATGAAGAGACTTTCATTCTTTAAATATTATTGACTTACAGTTTAAAAATAAATAAATAAAAGCATACTATAGTTGTAAA AACAAATAATTTTAATAGTATATTCAGTGGCTGAAGTGATAGGGAGTATTAATCATTATTTCTTCAGTATAAAGTTATTCTTCCTGAAAA AGTAAGATATACCTGGGAAATATTCTTGGATCCTTCACACATCCACTTAATTTCTTGAAGGAAGAAAACAGACAAAAGACATGTAACAAC AGAAACAAATAAACCACTTACTGTAAAATTTCAGAAATTGTGGGCTCATTCCCTCCCTCTAGTTTATTTATTTGCTCATCTTTATCACCT AATGGTAGTTTGTTTTCTTTGGTAGAGTATATGGCAGTCCCACATCGATGATAATTGGTGCTCCCTTCATCCAACTGGATCACTTTGAGA TTCAGTTTTACATCATTTTAGCATTTTGTTTGTATATCAGTTGTGATGAGCCACTGATAAAATTTTGTTCTAAAATGAAACATATTACTT TGTTAGTACATTTTTTAGTGTCACACTGACTTTTAAAATTTGAATGATATATAGACTTTGTTTTTTTAATGCAATATGAATATTTGCTCA >80075_80075_2_SEC24A-DDX46_SEC24A_chr5_134002686_ENST00000322887_DDX46_chr5_134113264_ENST00000452510_length(amino acids)=1074AA_BP=0 MSQPGIPASGGAPASLQAQNGAALASGSPYTNGPVQNALLSSQESVSQGYNFQLPGSYPHPIPAKTLNPVSGQSNYGGSQGSGQTLNRPP VASNPVTPSLHSGPAPRMPLPASQNPATTPMPSSSFLPEANLPPPLNWQYNYPSTASQTNHCPRASSQPTVSGNTSLTTNHQYVSSGYPS LQNSFIKSGPSVPPLVNPPLPTTFQPGAPHGPPPAGGPPPVRALTPLTSSYRDVPQPLFNSAVNQEDDEDDPAEAEKEGNEMEGEELDPL DAYMEEVKEEVKKFNMRSVKGGGGNEKKSGPTVTKVVTVVTTKKAVVDSDKKKGELMENDQDAMEYSSEEEEVDLQTALTGYQTKQRKLL EPVDHGKIEYEPFRKNFYVEVPELAKMSQEEVNVFRLEMEGITVKGKGCPKPIKSWVQCGISMKILNSLKKHGYEKPTPIQTQAIPAIMS GRDLIGIAKTGSGKTIAFLLPMFRHIMDQRSLEEGEGPIAVIMTPTRELALQITKECKKFSKTLGLRVVCVYGGTGISEQIAELKRGAEI IVCTPGRMIDMLAANSGRVTNLRRVTYVVLDEADRMFDMGFEPQVMRIVDNVRPDRQTVMFSATFPRAMEALARRILSKPIEVQVGGRSV VCSDVEQQVIVIEEEKKFLKLLELLGHYQESGSVIIFVDKQEHADGLLKDLMRASYPCMSLHGGIDQYDRDSIINDFKNGTCKLLVATSV AARGLDVKHLILVVNYSCPNHYEDYVHRAGRTGRAGNKGYAYTFITEDQARYAGDIIKALELSGTAVPPDLEKLWSDFKDQQKAEGKIIK KSSGFSGKGFKFDETEQALANERKKLQKAALGLQDSDDEDAAVDIDEQIESMFNSKKRVKDMAAPGTSSVPAPTAGNAEKLEIAKRLALR INAQKNLGIESQVDVMQQATNAILRGGTILAPTVSAKTIAEQLAEKINAKLNYVPLEKQEEERQDGGQNESFKRYEEELEINDFPQTARW -------------------------------------------------------------- >80075_80075_3_SEC24A-DDX46_SEC24A_chr5_134002686_ENST00000398844_DDX46_chr5_134113264_ENST00000354283_length(transcript)=4100nt_BP=1027nt CCGGCCAGGGCCTCCCTCCTTCTCTCTAGGTTTGGCTGCCGCCTTCTAGCCGGGCGTTCGCGGCCCCGCCGGCCCGACTCTCAAGCCTCA GCTCCCAGGCTAGGCTGTGGCCGCCGGTGGCCTGGGGAGAGTGCGGCGCCATGCCTCGGGCTTAATGCGCCCCCCCCTCTTCTCCCAGTC TTCAGTCTTAAGTCGTTAGCCTCCTCCCTCCGCTTTCAGCAGTGGTCTTTCAGCTCTCTTCTTGTGCGCTGTTGTCGACCCCGACCAGCC CCTTCCAACCCAGTCATCATGTCCCAGCCGGGAATACCGGCCTCCGGCGGCGCCCCAGCCAGCCTCCAGGCCCAGAACGGAGCCGCCTTG GCCTCGGGGTCTCCCTACACCAACGGTCCTGTCCAAAATGCATTGCTGTCTTCACAAGAGTCAGTGAGCCAAGGATACAATTTCCAGCTT CCAGGATCCTACCCTCATCCAATACCAGCAAAGACTTTGAATCCAGTCTCTGGACAGTCTAACTATGGTGGTTCTCAGGGATCTGGGCAG ACTCTTAATAGACCACCTGTGGCCTCTAATCCAGTGACACCTTCGCTTCATAGTGGTCCTGCTCCCCGAATGCCATTACCTGCTTCTCAG AACCCAGCTACTACACCAATGCCTTCTAGTAGCTTTCTTCCTGAAGCCAACCTGCCACCACCTTTGAATTGGCAATATAACTATCCATCC ACAGCCTCACAAACAAACCATTGTCCTCGTGCATCATCCCAACCAACTGTATCTGGAAATACAAGTTTAACCACAAATCATCAATATGTT TCTTCTGGATATCCTTCACTTCAAAATAGCTTCATAAAGTCAGGTCCTTCTGTACCTCCCTTAGTGAATCCACCTCTGCCTACAACTTTT CAACCAGGAGCTCCTCATGGGCCCCCTCCAGCTGGAGGCCCACCCCCAGTGAGGGCCCTCACGCCCCTGACATCATCATATAGAGATGTA CCCCAGCCCTTATTTAATTCAGCTGTCAACCAAGAAGATGACGAAGATGATCCTGCAGAAGCTGAAAAGGAGGGAAATGAAATGGAGGGT GAGGAGTTAGATCCATTAGATGCTTACATGGAAGAAGTGAAAGAGGAAGTAAAAAAATTTAACATGAGAAGTGTAAAAGGTGGTGGGGGA AATGAAAAGAAGTCTGGGCCAACGGTCACAAAAGTTGTCACTGTTGTGACAACCAAAAAAGCAGTTGTGGATTCTGATAAGAAGAAAGGT GAGCTGATGGAGAATGACCAGGATGCCATGGAGTATTCTTCAGAGGAGGAAGAAGTTGATCTTCAGACAGCCCTTACAGGGTATCAAACA AAACAGCGAAAGCTTCTAGAACCAGTTGATCATGGAAAAATTGAGTATGAGCCATTTAGGAAAAACTTCTATGTTGAAGTTCCAGAACTA GCAAAAATGTCTCAAGAAGAGGTAAATGTGTTTCGATTGGAAATGGAGGGCATTACAGTTAAAGGAAAAGGTTGCCCCAAACCAATTAAA TCCTGGGTCCAGTGTGGAATTTCCATGAAGATCTTAAATTCCCTCAAGAAGCATGGCTATGAAAAGCCCACGCCCATCCAAACCCAAGCT ATTCCTGCTATAATGTCTGGACGAGATTTGATTGGCATTGCCAAAACAGGAAGTGGAAAGACCATTGCTTTTCTGTTGCCCATGTTTAGA CACATCATGGATCAGAGGTCATTAGAGGAAGGAGAGGGGCCAATAGCTGTCATCATGACTCCAACTCGAGAACTGGCTTTACAGATTACT AAAGAGTGTAAGAAGTTTTCCAAGACTTTGGGACTTAGAGTGGTCTGTGTTTACGGAGGAACAGGAATCAGTGAGCAGATTGCTGAGCTG AAAAGAGGTGCTGAAATTATTGTTTGCACACCTGGTCGAATGATTGACATGTTAGCCGCTAACAGTGGTCGGGTCACAAATCTTCGAAGA GTGACATATGTTGTTTTAGATGAAGCAGACAGAATGTTTGACATGGGTTTTGAACCCCAGGTCATGCGCATCGTGGATAATGTTCGTCCT GATCGACAGACGGTTATGTTTTCAGCTACTTTCCCCAGAGCTATGGAGGCTTTGGCTCGCAGGATCCTCAGTAAACCTATTGAAGTACAA GTTGGAGGCAGGAGTGTGGTTTGCTCAGATGTGGAGCAACAAGTGATTGTGATTGAAGAAGAAAAGAAATTCTTGAAGTTACTTGAGCTT CTAGGCCATTATCAAGAGTCAGGATCTGTCATTATATTTGTGGATAAGCAGGAACATGCTGATGGTCTTCTTAAGGATTTAATGAGAGCA TCTTATCCTTGCATGTCTCTTCATGGAGGCATTGATCAATATGACAGAGATAGCATCATAAATGACTTTAAGAATGGGACCTGCAAACTT CTTGTGGCTACCTCTGTTGCTGCCCGAGGTCTAGATGTGAAACATCTGATTCTTGTAGTAAATTATAGCTGCCCCAACCATTATGAGGAT TATGTACACAGAGCAGGGCGGACTGGAAGAGCAGGAAACAAGGGTTATGCTTATACTTTTATCACAGAGGATCAAGCTCGCTATGCTGGT GACATAATTAAAGCTCTTGAATTGTCAGGGACTGCAGTACCTCCTGATTTAGAGAAACTGTGGAGTGATTTCAAAGATCAGCAGAAAGCT GAGGGGAAAATAATTAAAAAGAGTAGTGGGTTCTCTGGTAAGGGATTCAAGTTTGATGAAACAGAACAAGCTTTGGCTAATGAGAGGAAG AAGTTACAAAAAGCAGCTCTTGGTCTACAAGATTCAGATGATGAGGATGCTGCAGTTGATATTGATGAGCAAATTGAAAGCATGTTTAAT TCAAAGAAGAGAGTAAAGGATATGGCTGCTCCTGGAACATCAAGTGTTCCTGCTCCAACTGCAGGAAATGCTGAGAAATTAGAAATTGCT AAGAGATTGGCTCTTAGAATCAATGCCCAGAAGAATTTGGGCATCGAGTCTCAGGATGTGATGCAGCAGGCCACCAATGCAATTCTTAGG GGTGGCACCATTCTGGCTCCCACTGTTTCTGCAAAAACCATTGCAGAACAACTTGCTGAAAAGATCAATGCCAAGCTCAATTATGTGCCG TTAGAGAAACAAGAAGAAGAGAGACAGGATGGTGGACAGAATGAATCTTTTAAGAGATATGAAGAAGAATTAGAGATCAATGACTTCCCA CAGACTGCTAGGTGGAAAGTTACCTCTAAGGAAGCTCTGCAGAGAATCAGTGAATACTCTGAAGCCGCAATTACAATCAGAGGAACCTAC TTCCCTCCTGGCAAAGAACCCAAGGAAGGCGAGCGGAAGATTTACTTGGCAATTGAAAGTGCCAATGAACTGGCTGTGCAGAAAGCAAAG GCAGAAATCACCAGGCTCATAAAAGAAGAGCTGATCCGGCTGCAAAATTCATACCAACCAACAAATAAAGGAAGATACAAAGTCTTATAG ACATCCGGAAAAAAGATTTTTACCTGTGCTGGTCTATGATGTATGTGGCAGTTGCTGTCTGCAGTTTACAATGTATTGTAAATGAAGATT TTTTAAATTCTATCTTGCTGATTTTTTTTAAATATAAGAAACTGGTACTTGGTAAAGAAATCTGTCCGTAAGTACCCCCACAATCAGTCA AACTATATTTAAAGCCAGCCTGTTTTCAGAGTATGATGTCCTTTAATGTAAACTCAAATATCAATATTTTAAATGTCCGGATAATATTCT AGAGGTTTAAAAAATGGAAATATTTGAACTTTCTATTGAAGACAATAAAGTACACAAGTCGTTAAGGGGCTATTCACTTTATCCTGTACT TTCAATGAAATTGTGATCATTTCCTAAGAAAAGGTAAAATTCACTATCATATTTTGTGTCCCCACCTTGATGTTACATGACTCTGGAACA ATATGAACTGGATTTAAGAATGTTATAATAGAAGTCTTACAAAATGGGTTGAGAGTTTTTGTTTCAATTTTTATCATCATAAATGGGCAA >80075_80075_3_SEC24A-DDX46_SEC24A_chr5_134002686_ENST00000398844_DDX46_chr5_134113264_ENST00000354283_length(amino acids)=1073AA_BP=0 MSQPGIPASGGAPASLQAQNGAALASGSPYTNGPVQNALLSSQESVSQGYNFQLPGSYPHPIPAKTLNPVSGQSNYGGSQGSGQTLNRPP VASNPVTPSLHSGPAPRMPLPASQNPATTPMPSSSFLPEANLPPPLNWQYNYPSTASQTNHCPRASSQPTVSGNTSLTTNHQYVSSGYPS LQNSFIKSGPSVPPLVNPPLPTTFQPGAPHGPPPAGGPPPVRALTPLTSSYRDVPQPLFNSAVNQEDDEDDPAEAEKEGNEMEGEELDPL DAYMEEVKEEVKKFNMRSVKGGGGNEKKSGPTVTKVVTVVTTKKAVVDSDKKKGELMENDQDAMEYSSEEEEVDLQTALTGYQTKQRKLL EPVDHGKIEYEPFRKNFYVEVPELAKMSQEEVNVFRLEMEGITVKGKGCPKPIKSWVQCGISMKILNSLKKHGYEKPTPIQTQAIPAIMS GRDLIGIAKTGSGKTIAFLLPMFRHIMDQRSLEEGEGPIAVIMTPTRELALQITKECKKFSKTLGLRVVCVYGGTGISEQIAELKRGAEI IVCTPGRMIDMLAANSGRVTNLRRVTYVVLDEADRMFDMGFEPQVMRIVDNVRPDRQTVMFSATFPRAMEALARRILSKPIEVQVGGRSV VCSDVEQQVIVIEEEKKFLKLLELLGHYQESGSVIIFVDKQEHADGLLKDLMRASYPCMSLHGGIDQYDRDSIINDFKNGTCKLLVATSV AARGLDVKHLILVVNYSCPNHYEDYVHRAGRTGRAGNKGYAYTFITEDQARYAGDIIKALELSGTAVPPDLEKLWSDFKDQQKAEGKIIK KSSGFSGKGFKFDETEQALANERKKLQKAALGLQDSDDEDAAVDIDEQIESMFNSKKRVKDMAAPGTSSVPAPTAGNAEKLEIAKRLALR INAQKNLGIESQDVMQQATNAILRGGTILAPTVSAKTIAEQLAEKINAKLNYVPLEKQEEERQDGGQNESFKRYEEELEINDFPQTARWK -------------------------------------------------------------- >80075_80075_4_SEC24A-DDX46_SEC24A_chr5_134002686_ENST00000398844_DDX46_chr5_134113264_ENST00000452510_length(transcript)=5945nt_BP=1027nt CCGGCCAGGGCCTCCCTCCTTCTCTCTAGGTTTGGCTGCCGCCTTCTAGCCGGGCGTTCGCGGCCCCGCCGGCCCGACTCTCAAGCCTCA GCTCCCAGGCTAGGCTGTGGCCGCCGGTGGCCTGGGGAGAGTGCGGCGCCATGCCTCGGGCTTAATGCGCCCCCCCCTCTTCTCCCAGTC TTCAGTCTTAAGTCGTTAGCCTCCTCCCTCCGCTTTCAGCAGTGGTCTTTCAGCTCTCTTCTTGTGCGCTGTTGTCGACCCCGACCAGCC CCTTCCAACCCAGTCATCATGTCCCAGCCGGGAATACCGGCCTCCGGCGGCGCCCCAGCCAGCCTCCAGGCCCAGAACGGAGCCGCCTTG GCCTCGGGGTCTCCCTACACCAACGGTCCTGTCCAAAATGCATTGCTGTCTTCACAAGAGTCAGTGAGCCAAGGATACAATTTCCAGCTT CCAGGATCCTACCCTCATCCAATACCAGCAAAGACTTTGAATCCAGTCTCTGGACAGTCTAACTATGGTGGTTCTCAGGGATCTGGGCAG ACTCTTAATAGACCACCTGTGGCCTCTAATCCAGTGACACCTTCGCTTCATAGTGGTCCTGCTCCCCGAATGCCATTACCTGCTTCTCAG AACCCAGCTACTACACCAATGCCTTCTAGTAGCTTTCTTCCTGAAGCCAACCTGCCACCACCTTTGAATTGGCAATATAACTATCCATCC ACAGCCTCACAAACAAACCATTGTCCTCGTGCATCATCCCAACCAACTGTATCTGGAAATACAAGTTTAACCACAAATCATCAATATGTT TCTTCTGGATATCCTTCACTTCAAAATAGCTTCATAAAGTCAGGTCCTTCTGTACCTCCCTTAGTGAATCCACCTCTGCCTACAACTTTT CAACCAGGAGCTCCTCATGGGCCCCCTCCAGCTGGAGGCCCACCCCCAGTGAGGGCCCTCACGCCCCTGACATCATCATATAGAGATGTA CCCCAGCCCTTATTTAATTCAGCTGTCAACCAAGAAGATGACGAAGATGATCCTGCAGAAGCTGAAAAGGAGGGAAATGAAATGGAGGGT GAGGAGTTAGATCCATTAGATGCTTACATGGAAGAAGTGAAAGAGGAAGTAAAAAAATTTAACATGAGAAGTGTAAAAGGTGGTGGGGGA AATGAAAAGAAGTCTGGGCCAACGGTCACAAAAGTTGTCACTGTTGTGACAACCAAAAAAGCAGTTGTGGATTCTGATAAGAAGAAAGGT GAGCTGATGGAGAATGACCAGGATGCCATGGAGTATTCTTCAGAGGAGGAAGAAGTTGATCTTCAGACAGCCCTTACAGGGTATCAAACA AAACAGCGAAAGCTTCTAGAACCAGTTGATCATGGAAAAATTGAGTATGAGCCATTTAGGAAAAACTTCTATGTTGAAGTTCCAGAACTA GCAAAAATGTCTCAAGAAGAGGTAAATGTGTTTCGATTGGAAATGGAGGGCATTACAGTTAAAGGAAAAGGTTGCCCCAAACCAATTAAA TCCTGGGTCCAGTGTGGAATTTCCATGAAGATCTTAAATTCCCTCAAGAAGCATGGCTATGAAAAGCCCACGCCCATCCAAACCCAAGCT ATTCCTGCTATAATGTCTGGACGAGATTTGATTGGCATTGCCAAAACAGGAAGTGGAAAGACCATTGCTTTTCTGTTGCCCATGTTTAGA CACATCATGGATCAGAGGTCATTAGAGGAAGGAGAGGGGCCAATAGCTGTCATCATGACTCCAACTCGAGAACTGGCTTTACAGATTACT AAAGAGTGTAAGAAGTTTTCCAAGACTTTGGGACTTAGAGTGGTCTGTGTTTACGGAGGAACAGGAATCAGTGAGCAGATTGCTGAGCTG AAAAGAGGTGCTGAAATTATTGTTTGCACACCTGGTCGAATGATTGACATGTTAGCCGCTAACAGTGGTCGGGTCACAAATCTTCGAAGA GTGACATATGTTGTTTTAGATGAAGCAGACAGAATGTTTGACATGGGTTTTGAACCCCAGGTCATGCGCATCGTGGATAATGTTCGTCCT GATCGACAGACGGTTATGTTTTCAGCTACTTTCCCCAGAGCTATGGAGGCTTTGGCTCGCAGGATCCTCAGTAAACCTATTGAAGTACAA GTTGGAGGCAGGAGTGTGGTTTGCTCAGATGTGGAGCAACAAGTGATTGTGATTGAAGAAGAAAAGAAATTCTTGAAGTTACTTGAGCTT CTAGGCCATTATCAAGAGTCAGGATCTGTCATTATATTTGTGGATAAGCAGGAACATGCTGATGGTCTTCTTAAGGATTTAATGAGAGCA TCTTATCCTTGCATGTCTCTTCATGGAGGCATTGATCAATATGACAGAGATAGCATCATAAATGACTTTAAGAATGGGACCTGCAAACTT CTTGTGGCTACCTCTGTTGCTGCCCGAGGTCTAGATGTGAAACATCTGATTCTTGTAGTAAATTATAGCTGCCCCAACCATTATGAGGAT TATGTACACAGAGCAGGGCGGACTGGAAGAGCAGGAAACAAGGGTTATGCTTATACTTTTATCACAGAGGATCAAGCTCGCTATGCTGGT GACATAATTAAAGCTCTTGAATTGTCAGGGACTGCAGTACCTCCTGATTTAGAGAAACTGTGGAGTGATTTCAAAGATCAGCAGAAAGCT GAGGGGAAAATAATTAAAAAGAGTAGTGGGTTCTCTGGTAAGGGATTCAAGTTTGATGAAACAGAACAAGCTTTGGCTAATGAGAGGAAG AAGTTACAAAAAGCAGCTCTTGGTCTACAAGATTCAGATGATGAGGATGCTGCAGTTGATATTGATGAGCAAATTGAAAGCATGTTTAAT TCAAAGAAGAGAGTAAAGGATATGGCTGCTCCTGGAACATCAAGTGTTCCTGCTCCAACTGCAGGAAATGCTGAGAAATTAGAAATTGCT AAGAGATTGGCTCTTAGAATCAATGCCCAGAAGAATTTGGGCATCGAGTCTCAGGTAGATGTGATGCAGCAGGCCACCAATGCAATTCTT AGGGGTGGCACCATTCTGGCTCCCACTGTTTCTGCAAAAACCATTGCAGAACAACTTGCTGAAAAGATCAATGCCAAGCTCAATTATGTG CCGTTAGAGAAACAAGAAGAAGAGAGACAGGATGGTGGACAGAATGAATCTTTTAAGAGATATGAAGAAGAATTAGAGATCAATGACTTC CCACAGACTGCTAGGTGGAAAGTTACCTCTAAGGAAGCTCTGCAGAGAATCAGTGAATACTCTGAAGCCGCAATTACAATCAGAGGAACC TACTTCCCTCCTGGCAAAGAACCCAAGGAAGGCGAGCGGAAGATTTACTTGGCAATTGAAAGTGCCAATGAACTGGCTGTGCAGAAAGCA AAGGCAGAAATCACCAGGCTCATAAAAGAAGAGCTGATCCGGCTGCAAAATTCATACCAACCAACAAATAAAGGAAGATACAAAGTCTTA TAGACATCCGGAAAAAAGATTTTTACCTGTGCTGGTCTATGATGTATGTGGCAGTTGCTGTCTGCAGTTTACAATGTATTGTAAATGAAG ATTTTTTAAATTCTATCTTGCTGATTTTTTTTAAATATAAGAAACTGGTACTTGGTAAAGAAATCTGTCCGTAAGTACCCCCACAATCAG TCAAACTATATTTAAAGCCAGCCTGTTTTCAGAGTATGATGTCCTTTAATGTAAACTCAAATATCAATATTTTAAATGTCCGGATAATAT TCTAGAGGTTTAAAAAATGGAAATATTTGAACTTTCTATTGAAGACAATAAAGTACACAAGTCGTTAAGGGGCTATTCACTTTATCCTGT ACTTTCAATGAAATTGTGATCATTTCCTAAGAAAAGGTAAAATTCACTATCATATTTTGTGTCCCCACCTTGATGTTACATGACTCTGGA ACAATATGAACTGGATTTAAGAATGTTATAATAGAAGTCTTACAAAATGGGTTGAGAGTTTTTGTTTCAATTTTTATCATCATAAATGGG CAAAAAGTAGTTGGACTAATTTCGGTTTTTATACAAGTAAAGATTTAATAGTATAAGGATTTTTTTGCATTTCTTTACACTGAGTGTAAA ACTCTACAAAGAGTTATAGTATTTACTACTTTGAGGTTTCCCTCACAACTTCTGGCTCCATACCTAGCCCCTCTTTTATAATCTTCCTTA AAAGAAAGAGTGTAGCCTATAAATACTAAATATGATACCTTTTCCTTCTAGAAAGTGTTTATTTATATATCTATACATGTTGTATGTACA AATATCCTACTACTTTTAATCTGATTTTTCTTCAGGATTATTGAGTAGGTTGTGAATTTTCTTTCTTAAAAATTGTAAAACATAATGGTA CCCAAGTTTTAAACTTAGATGTGCTTCATCTTAGTGAAATTTAATTCACAAGGAATCATAAATTGTGTTTTTGAGGCTGGGCGCAGTGAC TCACACCTGTATCCCAGCAATTTGGGAGGCCGAGGTGGGCAGATCACTTGAGGTCAGGAGTTCAAGACTAGCCTGGTCAACATGGTGAAA CCCTGTCTCTACTAAAAATACAAAAATTAGTCGGCATGGTGGTGGGTGGCTGTAATCCCAGCTACTCAGGAGGCTGAGGCAGAAGAATCT GAGCCAAGATAACACCATTGCACTCCAGCCTGGGCGACAGAGTGAGACTATCTCAAAAATAAATAAATAAATAAATAAATAGTATTTTTG AGCCTTCAAGATACAGTTCCTGAATATTCTAATTTAAATTGTTATAATTGGATTACCTAATATTCTTTTCAAGACTCCTGATGTATTAAC TTCATGTTATTGTCACTTTTCAAAAAAGGAATTTTTTTCAGGAGTTAAATAAAGTCAGTCTTTTATATCCAAGGGTTTCAAACCCACAGA TTAAACCAACCACAGATCAAAAATAGAAAAAAAAAAAAAAAGAAAAAAAGAATGTAAAATTTTAAAAATACAGTTTAACAGCTGTAAAAG TTTTACTATAACATTTACATTGTGTTAGGTATTTTAAGTAATTTAAAGGTTACAGTATACAGGCGGTTAAAGTATACAGGAGGATGTGCA TCGGTTATATGCATATAGCAAGCCATTTCATATAAGAGGCTTGAACATCCATGGATTTTGGTATAGAGGAGGGGTTTAAGGGGTGTCCTG CAATCAGTCCCCCTCTCATACCAAAGGATGACTGTATATTTCTTAAATGAAGAGACTTTCATTCTTTAAATATTATTGACTTACAGTTTA AAAATAAATAAATAAAAGCATACTATAGTTGTAAAAACAAATAATTTTAATAGTATATTCAGTGGCTGAAGTGATAGGGAGTATTAATCA TTATTTCTTCAGTATAAAGTTATTCTTCCTGAAAAAGTAAGATATACCTGGGAAATATTCTTGGATCCTTCACACATCCACTTAATTTCT TGAAGGAAGAAAACAGACAAAAGACATGTAACAACAGAAACAAATAAACCACTTACTGTAAAATTTCAGAAATTGTGGGCTCATTCCCTC CCTCTAGTTTATTTATTTGCTCATCTTTATCACCTAATGGTAGTTTGTTTTCTTTGGTAGAGTATATGGCAGTCCCACATCGATGATAAT TGGTGCTCCCTTCATCCAACTGGATCACTTTGAGATTCAGTTTTACATCATTTTAGCATTTTGTTTGTATATCAGTTGTGATGAGCCACT GATAAAATTTTGTTCTAAAATGAAACATATTACTTTGTTAGTACATTTTTTAGTGTCACACTGACTTTTAAAATTTGAATGATATATAGA CTTTGTTTTTTTAATGCAATATGAATATTTGCTCATGTTTTCTAAATTCCTTATAAAATAAAATTAATTCGAATTCAATCTGCACTTTCT >80075_80075_4_SEC24A-DDX46_SEC24A_chr5_134002686_ENST00000398844_DDX46_chr5_134113264_ENST00000452510_length(amino acids)=1074AA_BP=0 MSQPGIPASGGAPASLQAQNGAALASGSPYTNGPVQNALLSSQESVSQGYNFQLPGSYPHPIPAKTLNPVSGQSNYGGSQGSGQTLNRPP VASNPVTPSLHSGPAPRMPLPASQNPATTPMPSSSFLPEANLPPPLNWQYNYPSTASQTNHCPRASSQPTVSGNTSLTTNHQYVSSGYPS LQNSFIKSGPSVPPLVNPPLPTTFQPGAPHGPPPAGGPPPVRALTPLTSSYRDVPQPLFNSAVNQEDDEDDPAEAEKEGNEMEGEELDPL DAYMEEVKEEVKKFNMRSVKGGGGNEKKSGPTVTKVVTVVTTKKAVVDSDKKKGELMENDQDAMEYSSEEEEVDLQTALTGYQTKQRKLL EPVDHGKIEYEPFRKNFYVEVPELAKMSQEEVNVFRLEMEGITVKGKGCPKPIKSWVQCGISMKILNSLKKHGYEKPTPIQTQAIPAIMS GRDLIGIAKTGSGKTIAFLLPMFRHIMDQRSLEEGEGPIAVIMTPTRELALQITKECKKFSKTLGLRVVCVYGGTGISEQIAELKRGAEI IVCTPGRMIDMLAANSGRVTNLRRVTYVVLDEADRMFDMGFEPQVMRIVDNVRPDRQTVMFSATFPRAMEALARRILSKPIEVQVGGRSV VCSDVEQQVIVIEEEKKFLKLLELLGHYQESGSVIIFVDKQEHADGLLKDLMRASYPCMSLHGGIDQYDRDSIINDFKNGTCKLLVATSV AARGLDVKHLILVVNYSCPNHYEDYVHRAGRTGRAGNKGYAYTFITEDQARYAGDIIKALELSGTAVPPDLEKLWSDFKDQQKAEGKIIK KSSGFSGKGFKFDETEQALANERKKLQKAALGLQDSDDEDAAVDIDEQIESMFNSKKRVKDMAAPGTSSVPAPTAGNAEKLEIAKRLALR INAQKNLGIESQVDVMQQATNAILRGGTILAPTVSAKTIAEQLAEKINAKLNYVPLEKQEEERQDGGQNESFKRYEEELEINDFPQTARW -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for SEC24A-DDX46 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for SEC24A-DDX46 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for SEC24A-DDX46 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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