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 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:SEC24A-PCBD2 (FusionGDB2 ID:80078) |
Fusion Gene Summary for SEC24A-PCBD2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: SEC24A-PCBD2 | Fusion gene ID: 80078 | Hgene | Tgene | Gene symbol | SEC24A | PCBD2 | Gene ID | 10802 | 84105 |
| Gene name | SEC24 homolog A, COPII coat complex component | pterin-4 alpha-carbinolamine dehydratase 2 | |
| Synonyms | - | DCOH2|DCOHM|PHS2 | |
| Cytomap | 5q31.1 | 5q31.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | protein transport protein Sec24ASEC24 family, member ASEC24 related gene family, member ASEC24-related protein A | pterin-4-alpha-carbinolamine dehydratase 24-alpha-hydroxy-tetrahydropterin dehydratase 26-pyruvoyl-tetrahydropterin synthase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1) 2DcoH-like protein DCoHmHNF-1-alpha dimerization cofactorPH | |
| Modification date | 20200327 | 20200313 | |
| UniProtAcc | . | . | |
| Ensembl transtripts involved in fusion gene | ENST00000322887, ENST00000398844, | ENST00000510013, ENST00000254908, ENST00000512783, | |
| Fusion gene scores | * DoF score | 8 X 6 X 8=384 | 12 X 26 X 5=1560 |
| # samples | 9 | 22 | |
| ** MAII score | log2(9/384*10)=-2.09310940439148 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(22/1560*10)=-2.82597060022495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: SEC24A [Title/Abstract] AND PCBD2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | SEC24A(134028347)-PCBD2(134294730), # samples:1 | ||
| Anticipated loss of major functional domain due to fusion event. | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | SEC24A | GO:0090110 | cargo loading into COPII-coated vesicle | 17499046|18843296 |
| Tgene | PCBD2 | GO:0045893 | positive regulation of transcription, DNA-templated | 11980910 |
| Fusion gene breakpoints across SEC24A (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene breakpoints across PCBD2 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | HNSC | TCGA-HD-7832-01A | SEC24A | chr5 | 134028347 | + | PCBD2 | chr5 | 134294730 | + |
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Fusion Gene ORF analysis for SEC24A-PCBD2 |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-3UTR | ENST00000322887 | ENST00000510013 | SEC24A | chr5 | 134028347 | + | PCBD2 | chr5 | 134294730 | + |
| 5CDS-3UTR | ENST00000398844 | ENST00000510013 | SEC24A | chr5 | 134028347 | + | PCBD2 | chr5 | 134294730 | + |
| In-frame | ENST00000322887 | ENST00000254908 | SEC24A | chr5 | 134028347 | + | PCBD2 | chr5 | 134294730 | + |
| In-frame | ENST00000322887 | ENST00000512783 | SEC24A | chr5 | 134028347 | + | PCBD2 | chr5 | 134294730 | + |
| In-frame | ENST00000398844 | ENST00000254908 | SEC24A | chr5 | 134028347 | + | PCBD2 | chr5 | 134294730 | + |
| In-frame | ENST00000398844 | ENST00000512783 | SEC24A | chr5 | 134028347 | + | PCBD2 | chr5 | 134294730 | + |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000398844 | SEC24A | chr5 | 134028347 | + | ENST00000254908 | PCBD2 | chr5 | 134294730 | + | 2840 | 2067 | 288 | 2243 | 651 |
| ENST00000398844 | SEC24A | chr5 | 134028347 | + | ENST00000512783 | PCBD2 | chr5 | 134294730 | + | 7452 | 2067 | 288 | 2243 | 651 |
| ENST00000322887 | SEC24A | chr5 | 134028347 | + | ENST00000254908 | PCBD2 | chr5 | 134294730 | + | 2805 | 2032 | 253 | 2208 | 651 |
| ENST00000322887 | SEC24A | chr5 | 134028347 | + | ENST00000512783 | PCBD2 | chr5 | 134294730 | + | 7417 | 2032 | 253 | 2208 | 651 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000398844 | ENST00000254908 | SEC24A | chr5 | 134028347 | + | PCBD2 | chr5 | 134294730 | + | 0.001643717 | 0.9983563 |
| ENST00000398844 | ENST00000512783 | SEC24A | chr5 | 134028347 | + | PCBD2 | chr5 | 134294730 | + | 0.000659958 | 0.99934 |
| ENST00000322887 | ENST00000254908 | SEC24A | chr5 | 134028347 | + | PCBD2 | chr5 | 134294730 | + | 0.001604823 | 0.99839514 |
| ENST00000322887 | ENST00000512783 | SEC24A | chr5 | 134028347 | + | PCBD2 | chr5 | 134294730 | + | 0.000642242 | 0.99935776 |
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Fusion Genomic Features for SEC24A-PCBD2 |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| SEC24A | chr5 | 134028347 | + | PCBD2 | chr5 | 134294729 | + | 3.12E-10 | 1 |
| SEC24A | chr5 | 134028347 | + | PCBD2 | chr5 | 134294729 | + | 3.12E-10 | 1 |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
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| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for SEC24A-PCBD2 |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr5:134028347/chr5:134294730) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| . | . |
| FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. | FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | SEC24A | chr5:134028347 | chr5:134294730 | ENST00000322887 | + | 12 | 13 | 89_237 | 593 | 614.0 | Compositional bias | Note=Pro-rich |
| Hgene | SEC24A | chr5:134028347 | chr5:134294730 | ENST00000398844 | + | 12 | 23 | 89_237 | 593 | 1094.0 | Compositional bias | Note=Pro-rich |
| Hgene | SEC24A | chr5:134028347 | chr5:134294730 | ENST00000322887 | + | 12 | 13 | 431_455 | 593 | 614.0 | Region | Note=Zinc finger-like |
| Hgene | SEC24A | chr5:134028347 | chr5:134294730 | ENST00000398844 | + | 12 | 23 | 431_455 | 593 | 1094.0 | Region | Note=Zinc finger-like |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | SEC24A | chr5:134028347 | chr5:134294730 | ENST00000322887 | + | 12 | 13 | 966_1038 | 593 | 614.0 | Repeat | Gelsolin-like |
| Hgene | SEC24A | chr5:134028347 | chr5:134294730 | ENST00000398844 | + | 12 | 23 | 966_1038 | 593 | 1094.0 | Repeat | Gelsolin-like |
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Fusion Gene Sequence for SEC24A-PCBD2 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >80078_80078_1_SEC24A-PCBD2_SEC24A_chr5_134028347_ENST00000322887_PCBD2_chr5_134294730_ENST00000254908_length(transcript)=2805nt_BP=2032nt CTGCCGCCTTCTAGCCGGGCGTTCGCGGCCCCGCCGGCCCGACTCTCAAGCCTCAGCTCCCAGGCTAGGCTGTGGCCGCCGGTGGCCTGG GGAGAGTGCGGCGCCATGCCTCGGGCTTAATGCGCCCCCCCCTCTTCTCCCAGTCTTCAGTCTTAAGTCGTTAGCCTCCTCCCTCCGCTT TCAGCAGTGGTCTTTCAGCTCTCTTCTTGTGCGCTGTTGTCGACCCCGACCAGCCCCTTCCAACCCAGTCATCATGTCCCAGCCGGGAAT ACCGGCCTCCGGCGGCGCCCCAGCCAGCCTCCAGGCCCAGAACGGAGCCGCCTTGGCCTCGGGGTCTCCCTACACCAACGGTCCTGTCCA AAATGCATTGCTGTCTTCACAAGAGTCAGTGAGCCAAGGATACAATTTCCAGCTTCCAGGATCCTACCCTCATCCAATACCAGCAAAGAC TTTGAATCCAGTCTCTGGACAGTCTAACTATGGTGGTTCTCAGGGATCTGGGCAGACTCTTAATAGACCACCTGTGGCCTCTAATCCAGT GACACCTTCGCTTCATAGTGGTCCTGCTCCCCGAATGCCATTACCTGCTTCTCAGAACCCAGCTACTACACCAATGCCTTCTAGTAGCTT TCTTCCTGAAGCCAACCTGCCACCACCTTTGAATTGGCAATATAACTATCCATCCACAGCCTCACAAACAAACCATTGTCCTCGTGCATC ATCCCAACCAACTGTATCTGGAAATACAAGTTTAACCACAAATCATCAATATGTTTCTTCTGGATATCCTTCACTTCAAAATAGCTTCAT AAAGTCAGGTCCTTCTGTACCTCCCTTAGTGAATCCACCTCTGCCTACAACTTTTCAACCAGGAGCTCCTCATGGGCCCCCTCCAGCTGG AGGCCCACCCCCAGTGAGGGCCCTCACGCCCCTGACATCATCATATAGAGATGTACCCCAGCCCTTATTTAATTCAGCTGTCAACCAAGA AGGTATTACATCAAATACCAATAACGGATCTATGGTGGTCCACAGTAGTTACGACGAGATTGAAGGAGGTGGCTTATTGGCAACACCACA GCTTACTAACAAGAATCCCAAAATGAGCCGAAGTGTTGGATATTCATATCCCTCCTTACCACCTGGTTATCAGAACACAACACCACCTGG TGCAACTGGAGTACCACCCTCTTCCTTGAATTACCCAAGTGGGCCACAAGCCTTTACTCAGACTCCCTTAGGTGCTAATCATTTAACCAC AAGCATGAGTGGATTAAGTCTACAACCAGAGGGTCTAAGAGTTGTCAATCTTCTTCAAGAAAGAAACATGCTTCCGTCAACACCTTTGAA GCCTCCAGTTCCAAATTTGCATGAAGACATCCAGAAACTCAACTGTAACCCAGAGTTATTTCGATGCACGCTGACTAGCATTCCTCAGAC GCAGGCCTTATTGAATAAAGCCAAACTTCCTTTGGGGCTGCTGCTTCATCCTTTCAAAGACTTAGTGCAATTGCCTGTGGTTACCTCCAG TACAATTGTGAGATGCCGTTCATGCAGGACGTACATCAATCCTTTCGTCAGCTTTCTTGATCAAAGGAGATGGAAGTGTAACTTATGTTA TCGAGTCAATGATGTTCCTGAAGAATTCTTGTACAACCCTTTGACCAGAGTTTATGGAGAACCTCACAGAAGACCAGAAGTTCAAAATGC TACTATTGAGTTTATGGCTCCTTCAGAATACATGTTACGACCACCTCAGCCTCCAGTGTATCTCTTTGTATTTGATGTGTCTCACAATGC AGTCGAAACTGGATACTTGAATTCAGTTTGCCAGAGTTTGTTAGACAATCTGGATTTGCTTCCTGGCAACACTAGAACAAAAATTGGCTT CATAACATTTGACAGTACAATCCATTTCTACGGTCTTCAGGAAAGTCTCTCTCAACCTCAGATGCTAATAGTTTCAGATATTGAAGATGT TTTTATACCTATGCCAGAGAACTTATTAGTAAACTTAAATGAAAGTAAAGAGGCATTTGGCTTTATGTCCCGAGTTGCCCTACAAGCAGA GAAGATGAATCATCACCCAGAATGGTTCAATGTATACAACAAGGTCCAGATAACTCTCACCTCACATGACTGTGGTGAACTGACCAAAAA AGATGTGAAGCTGGCCAAGTTTATTGAAAAAGCAGCTGCTTCTGTGTGATTTCTTCCAAAATACATGTAAAATCTTGTACACATCTTAGC TGCAATGTATGTTGAAGGAAATTTATGTGAACAAATAGAGTTGTTCTTTTTCTCTTTTTTTTAAGACAGAGTGTTGCTCTGTCGCCCAGG CCAGAGTGCAGTGGTATGATCTCGGCTCACTGTAACCTCCGCCTCCCAGGTTCAGGTGATTCTCCTGCCTCAGCCTCCTGAGTAGCTGGG ATTACAAGCACGTGTCACCACGCCTGGCTAATTTTTGTATTTTTAGTATAGACAGGGTTTTACCACGTTGGTCAGGCTGGTCTCGAACTC CTGACCTCGTGATCCGCCTGCCTCAGCCTCCCAAAGTGCTGGGATTACAGGCATGAGCCACCATGCCTGGCTGTTGAATTGTTCTTAAGG CATCATATCTAGAAGCAAAGAAAAAAGAAAAATAACAATTTAAGTTGTGTAAATTGTTTGCCTTTATATATTACATTTGGTAAAATCAGT GCTTAAATACGCAATGATTTAAACTGGAACCTGAGGTATTTTTCATGCTATCTAATCATATACCTAAGATAAACCAACCCAGTTACTTAT >80078_80078_1_SEC24A-PCBD2_SEC24A_chr5_134028347_ENST00000322887_PCBD2_chr5_134294730_ENST00000254908_length(amino acids)=651AA_BP=0 MSQPGIPASGGAPASLQAQNGAALASGSPYTNGPVQNALLSSQESVSQGYNFQLPGSYPHPIPAKTLNPVSGQSNYGGSQGSGQTLNRPP VASNPVTPSLHSGPAPRMPLPASQNPATTPMPSSSFLPEANLPPPLNWQYNYPSTASQTNHCPRASSQPTVSGNTSLTTNHQYVSSGYPS LQNSFIKSGPSVPPLVNPPLPTTFQPGAPHGPPPAGGPPPVRALTPLTSSYRDVPQPLFNSAVNQEGITSNTNNGSMVVHSSYDEIEGGG LLATPQLTNKNPKMSRSVGYSYPSLPPGYQNTTPPGATGVPPSSLNYPSGPQAFTQTPLGANHLTTSMSGLSLQPEGLRVVNLLQERNML PSTPLKPPVPNLHEDIQKLNCNPELFRCTLTSIPQTQALLNKAKLPLGLLLHPFKDLVQLPVVTSSTIVRCRSCRTYINPFVSFLDQRRW KCNLCYRVNDVPEEFLYNPLTRVYGEPHRRPEVQNATIEFMAPSEYMLRPPQPPVYLFVFDVSHNAVETGYLNSVCQSLLDNLDLLPGNT RTKIGFITFDSTIHFYGLQESLSQPQMLIVSDIEDVFIPMPENLLVNLNESKEAFGFMSRVALQAEKMNHHPEWFNVYNKVQITLTSHDC -------------------------------------------------------------- >80078_80078_2_SEC24A-PCBD2_SEC24A_chr5_134028347_ENST00000322887_PCBD2_chr5_134294730_ENST00000512783_length(transcript)=7417nt_BP=2032nt CTGCCGCCTTCTAGCCGGGCGTTCGCGGCCCCGCCGGCCCGACTCTCAAGCCTCAGCTCCCAGGCTAGGCTGTGGCCGCCGGTGGCCTGG GGAGAGTGCGGCGCCATGCCTCGGGCTTAATGCGCCCCCCCCTCTTCTCCCAGTCTTCAGTCTTAAGTCGTTAGCCTCCTCCCTCCGCTT TCAGCAGTGGTCTTTCAGCTCTCTTCTTGTGCGCTGTTGTCGACCCCGACCAGCCCCTTCCAACCCAGTCATCATGTCCCAGCCGGGAAT ACCGGCCTCCGGCGGCGCCCCAGCCAGCCTCCAGGCCCAGAACGGAGCCGCCTTGGCCTCGGGGTCTCCCTACACCAACGGTCCTGTCCA AAATGCATTGCTGTCTTCACAAGAGTCAGTGAGCCAAGGATACAATTTCCAGCTTCCAGGATCCTACCCTCATCCAATACCAGCAAAGAC TTTGAATCCAGTCTCTGGACAGTCTAACTATGGTGGTTCTCAGGGATCTGGGCAGACTCTTAATAGACCACCTGTGGCCTCTAATCCAGT GACACCTTCGCTTCATAGTGGTCCTGCTCCCCGAATGCCATTACCTGCTTCTCAGAACCCAGCTACTACACCAATGCCTTCTAGTAGCTT TCTTCCTGAAGCCAACCTGCCACCACCTTTGAATTGGCAATATAACTATCCATCCACAGCCTCACAAACAAACCATTGTCCTCGTGCATC ATCCCAACCAACTGTATCTGGAAATACAAGTTTAACCACAAATCATCAATATGTTTCTTCTGGATATCCTTCACTTCAAAATAGCTTCAT AAAGTCAGGTCCTTCTGTACCTCCCTTAGTGAATCCACCTCTGCCTACAACTTTTCAACCAGGAGCTCCTCATGGGCCCCCTCCAGCTGG AGGCCCACCCCCAGTGAGGGCCCTCACGCCCCTGACATCATCATATAGAGATGTACCCCAGCCCTTATTTAATTCAGCTGTCAACCAAGA AGGTATTACATCAAATACCAATAACGGATCTATGGTGGTCCACAGTAGTTACGACGAGATTGAAGGAGGTGGCTTATTGGCAACACCACA GCTTACTAACAAGAATCCCAAAATGAGCCGAAGTGTTGGATATTCATATCCCTCCTTACCACCTGGTTATCAGAACACAACACCACCTGG TGCAACTGGAGTACCACCCTCTTCCTTGAATTACCCAAGTGGGCCACAAGCCTTTACTCAGACTCCCTTAGGTGCTAATCATTTAACCAC AAGCATGAGTGGATTAAGTCTACAACCAGAGGGTCTAAGAGTTGTCAATCTTCTTCAAGAAAGAAACATGCTTCCGTCAACACCTTTGAA GCCTCCAGTTCCAAATTTGCATGAAGACATCCAGAAACTCAACTGTAACCCAGAGTTATTTCGATGCACGCTGACTAGCATTCCTCAGAC GCAGGCCTTATTGAATAAAGCCAAACTTCCTTTGGGGCTGCTGCTTCATCCTTTCAAAGACTTAGTGCAATTGCCTGTGGTTACCTCCAG TACAATTGTGAGATGCCGTTCATGCAGGACGTACATCAATCCTTTCGTCAGCTTTCTTGATCAAAGGAGATGGAAGTGTAACTTATGTTA TCGAGTCAATGATGTTCCTGAAGAATTCTTGTACAACCCTTTGACCAGAGTTTATGGAGAACCTCACAGAAGACCAGAAGTTCAAAATGC TACTATTGAGTTTATGGCTCCTTCAGAATACATGTTACGACCACCTCAGCCTCCAGTGTATCTCTTTGTATTTGATGTGTCTCACAATGC AGTCGAAACTGGATACTTGAATTCAGTTTGCCAGAGTTTGTTAGACAATCTGGATTTGCTTCCTGGCAACACTAGAACAAAAATTGGCTT CATAACATTTGACAGTACAATCCATTTCTACGGTCTTCAGGAAAGTCTCTCTCAACCTCAGATGCTAATAGTTTCAGATATTGAAGATGT TTTTATACCTATGCCAGAGAACTTATTAGTAAACTTAAATGAAAGTAAAGAGGCATTTGGCTTTATGTCCCGAGTTGCCCTACAAGCAGA GAAGATGAATCATCACCCAGAATGGTTCAATGTATACAACAAGGTCCAGATAACTCTCACCTCACATGACTGTGGTGAACTGACCAAAAA AGATGTGAAGCTGGCCAAGTTTATTGAAAAAGCAGCTGCTTCTGTGTGATTTCTTCCAAAATACATAAGTCTGAGAGGCTAAACTTGATG GCTGTGTTAACATATGTCACGTGTAGCACAGTGGAGAAAGCAGGATATGGCTCATAATGACAGTGGTGAAGACCTGCGAATGAAGTTGCT AGTTATCACCTACATTAGGGTTTGACATAGGTCTATGTTATGGGTCGCTGCATCTGCTGGAACTCACAGACTTTACTATAGAGAATCAAA GATCCCGTATCCGAAGTCTATGGAAATGCTCATGGTGGTAAATTCCAACAGAATGAAACACCAAACTTGCTTAAAGTAACTCACGTTTCA ATTTGAAAGAGATATTGTCAAAATTGGAGGCCCCCAGGTTCCTGTCTGTTCCAAATCTTTGCATGATGACAGTGGTTTCTCTGATGTGGT AAGCTTTGGCTTTCTTCTGTTTTCTTTCTAAAAGATCACTGGAGTAGAGAGGAGTTAAACAGACATGACCTTTGACCTCTTGCATGACCT CCACAGATAGCAAACCGGGCCGACACATGGTTGACGATGTCCTTTTCTACAATGAAGTTAATGAAAGTTCTGAAAATAGTGATTACTTTC TGACATTGATAGGATTTAGGAAACCTCTGGATAAATAGCTTAAGCATGGCTGTTTATGTTTTTGCTATAGACAAAAAGCAGCAGCATGTA CATTGTATTTGGACACAAGCCTGCCTCGGTTAATATATTGAACTATTGGACCACTAGGGTTAGTAGGGAGCGGTCTGTACACTTTCTGAT TCAGCATTCAGAAACATTCTAGGTGGACTCTGTAGCTTTCAGTTTTGTAAAGTTATCAGAAAAACATCGGGAGGGTTTGGCCATCATATG TGAGCTTTGTGTTTCAATGCCAGTTACTCAGGATTAGTAAATTAATGACTGTCCAGAGGACTTCAGGGTCACCAAGCTGCTGCACCTGCC ATTGGCTGACTCTCCCCGGCTATCTGTGGCTGAGATGGTGCTGCTTAGGTCACGCAGAGCATGAGCTGCTGCTGAAAGGGCACAGGAGAT GGCCCTTGGGCTTCTCATCCCAGGATGCCTGCCCTGCCCACCAATCCATGAGAAGATATGTATGATTTCAGTAGGCCCTGGATCAGCTTG TCACCTCTGGTTTCCTGTTTGCTTTCCACTCACTCAGCTGGAGTTTCATTTCCAGACTAAAGTCTTCATCATTGGCTTCAGAAACAGCAT TCATCTGTGGCTGTGCTGATGTAGTACACCAAGAACAACTGGGCTCTTCTCTGTCACTTTCAGTGGGCTACCTTCCCTCACCTCTCCAAG CAGCATGAAAGAATTCTTTACATTTTTAATCTCTTTTTTGTTTTTCCCTGAAAGTATGCTTTGGTGCTTAAAGAGAGAAGTCACAAAAGT ATACTACTGAGTTTCCTGGAGATGAAATCCTGTTGTCCCTAGCTATGTGAATGAGCACAGGGATCCCTGATGCCATTATTTTGTATATTC ATACGGCACACACTTACTGAGGGCCTTCTGTGTGCCCTAGGGGATTGAGCACAGTGACATATCAGGGCAGGTAGAAACAGATGGAGAGCT GATGCGGGCTGTCTTAGAGCAGCTGCCCCAGGAGGCCCCTGTGGATGGATGTTGGGCAGGAGCCCTGAGACGTTAGGGGCATATAACTAA AGGACATAGCAGGAGTTATAGGAGGAGCTGATCCCTGAGGGAAACAATGAAGACGGAGAAGATGGGGCTAAAGTTTGAATTGTGGGGACA TTAATCACAGTGATTCTTAAAACTTTGCTGTTGATGATTTTAAATGGAGAAAATGAGTACGTAAGATGTTATTTCCCAGTTCAGTATATT GGTTGCCCACAAAGTATTTTCCTACCATGAATGGTCATATATACTTGTTGTAGAATACCAGGGACAGCAGAGATGGTGGGGTAGTTACTT CCTTTTCTTACAGCCCAAGAACTTTGGTGTCCAGGAGATTGACCAATTTAGCCACTGAGCATTTAATACAACACAGGGCTACCCAGATCC CACTGTCCTGATTTGCCCTGAAAGCCAAAGGAGTTAGGAGAAGGTGAGTGGGGAGAATATATTAATCCTGAGAGTTGAACAGAGCAAAAA TCCCTATTACTTTTGTACTTAAAACATCTCTGCCACATGTGCTCACTCTTTATATTCTGTTTAGGTGGTTTATATGTGCACATCCCATCC TATGCCTGCAGTTAGCCAACTCAGGGTTTATATTGCCTCCTTTCTTTTTTTCTTTTTTTTTTTTTTTTTAAGAGATGGGGTCTCATTCTA TCATGCAGACTGGAGTGCAGTGGTGTGATCACAGCTCATTGTAACCTCCAACGCCTGGACTAAAGTGATCCTCCTACCTTGGCCTCTCTG GTAGCTGGGACTACAGGTGCATGCCACCACACCCACCTAATTTTTTTTATTTTTATTTTTTGTAGAGACAGTCTCACTATCTTGCTCAGG CTAGTCCTGAACTCCTGGGCTCAAGTTATCTTGCTGCCTCAGCCTCCCATGGGTAATTTTTATTTCCTTTTTTTTTTTTTTTGGAGATGG AGTTTCGCTCTTGTCGCCCAGGCTGGAGTGCAATGGCACGATCTTGGCTCACTGCAGTCTCCACCTCCTGGGTTCAAGTGATTCTCCATC CTCAGCCTCCTGAGTAGCTGAGATTACAGGCAACTGCCACCATGCGCGGCTAATTTATGTATTTTTTTTTAGTAAGAGATGGGGTTTCAC CATGTTGGCCAGACTAGTCTTAAACTCCTGACCTCAAGCGACCTGCCTGCCTTGGCCTCCCAAAGTGCTGGGATTACAGGCATGAGCCGC TATGCCTCGTCGCTGATTTTTATTTCTTATTTTTTTTTTAGAGATGGGGGTCTCACTATGTTGCTCAGGCTGATCTCAAACTCCTGGCCT CAAGTGATCCTCCCACCTTAGCCTCCCAAGTTGCTGGGATTATAAGTGTGAGCCACTATCCCTACCTCACTATTACCTTCTTTGCTTCTC TTGTTTTCTTTTGTTCTAAGTCAAACCCATCACAATCTTTTCTTGTCCTTCCAGGTGTTTTCCAGTGCTGTGCCCTGGATGTGCTCTCTT TCTCTTAGAGCCCAGAGAACTTGCTTTTCCCCCTTATATATGACCCTTAACTTTTTCTAACACATTATTAAGGGCCTGTGTCTATCAGCT GGGGGCACTTCTTGAAGGGAGGGCCTTTGTGTGGTCTGTTTCTAGTGACTTCCAGCTTTAACCCAGAGCCTCATGATTGCTGGGTGCCCA TAGCCTTTTTGCTGAATGGAGGCACTCAGTCTCCTTGGGAAGAGAGAATCCATGATAGACCCACTTGGGAGCTCCCCACTTCAGGGGCCT ACACACTGGTAATGCAACAGAATGCCCAAGAGTGACCTCATAAAGCAAGGATTCCCTTCGTGGCCCCTTCTCTGCTGCCTCTCAGAATCC AGACGCTAAGGAAAATCCCTAAGCAGAGATTTTCTGTTGGATGCTAAAAGCAAGGAATAAAAGTTGAAAATTTGGAAAATGTCTCAACAC CGTCACCAGCGCCACTCGAGAGTCATTTCTAGTTCACCAGTTGACACTACATCGGTGGGATTTTGCCCAACATTCAAGAAATTTAAGTAA ATATTATCTATCTCCATTGCCTGTTAAGAAATGTGCTAGTAGAAGTGTGAGGGCAGGGTGTCAGTGTTCTCTCAGCCTCTTCCCTCAGAT ACTCGTCTGCTTACCAAAATAAGTTGCATGTCCTTGACAATCTGGTTTCTATGATTGGTGAGGCTGGCATGCTATTACCTTTATGTGCCC TGTAGACTTGAATGACCAGTTTGACCAGTTTGACTGTTAGATAATCTGAAGGCTTTTCTCTTTTTTTATAATAGACCCCATCTCAAATCA GATAATGAAAATTACATATCTTGATATATTAGAAAAGTATATACATTCTGGCTGGGCACGGTGGCTCACACCTGTAATCCCTGCACTTTG AGAGGCTGGGGCGGATCACTTGAGGTCAGGAGTTTGAGACCAGCCTGGCCAACGTGGCGAAACCCCATCTCTACTAAAAATACACAGATT AGCCCGGAGTGATGGTGTGCACCTGTTGTCCCAGCTACTCAGGATGCTGAGGCAGGAGAATCCCTTTAACCTGGGGGGCGAAGGTTGCAG TGAGCCAAGATTGCACCACTGCACTCCAGCCTGGGTGACAGAACGAGACTCTGTCTCAGAAAAAAAAAAAAAGAAAAGGAAAAAGAAAAA TATATATTCTATATTTTTTTAACTTATGAGAATGTGTTCATTTCATTTGTAACATATAATGGGAAACAGTAATACGTACTCTGAGAAAAA TTGCAAAGCACAGATAAATGGAAATAAACAGGAAAAAGAATCACCTATAACCTCACCATCCATAGACAGACACTGTTAAAATTTTGGCAT ATTTCCTGCTGATTTTTTCTACTGCTGATTTTTGCACAGGTGAGATAATTTTGAACAGAGAATTTTGTATCTTTGGTTTTTGTGTTTTGC TGCACACAAAAACAAAAGATATAAAAATGGATCATAAACATTTTTCTAAATCCTGAAAAATGCATAGACATATTTTAGTGCCTGTATTTC ACAAGATGGACATACCATAATTTACTTACACAGTCCTTTTTGTTAGATGTTTAAGTTGTTTTCAAGCTTCTCAGTGCTGGAAAAAATACT GAGATAGACATGTTTAGTTGAAGTTATTTCATTTCAGGTTATATTATCTTGGGTCAGAGAATGAATGGTTCTCAGGCTTTTCAAAAGAGC TGGTCAGTTTTTATGCCTCTGGCAGTTTTTGAGAGTGCTCAATCATACTACACTGTTGCCAGCATTAGATCTTATCACATTTAAGTCATT GCTAATTTTATAAACAAAAACAATGGTTTTACTTTGCATCTCCCTGATTGGTATTGCTGTAGAACATATTTGGAGAAGTTTGTTTGTCTT TGGTGTTTATTTCATGAATAGATTGTGTGCCCATTTTCTCTTGGGGTATTCAGTTTTTTATTACTGATGTGAGCATGTGTATGGGTGATT ATTTGATGATTATCAGTTTTGCTTAGTAGACTGGCAATATTTAGTCTTGCTGTCACTGTGTTCCCAGTGCCTACTAGATTGCTTGATATG >80078_80078_2_SEC24A-PCBD2_SEC24A_chr5_134028347_ENST00000322887_PCBD2_chr5_134294730_ENST00000512783_length(amino acids)=651AA_BP=0 MSQPGIPASGGAPASLQAQNGAALASGSPYTNGPVQNALLSSQESVSQGYNFQLPGSYPHPIPAKTLNPVSGQSNYGGSQGSGQTLNRPP VASNPVTPSLHSGPAPRMPLPASQNPATTPMPSSSFLPEANLPPPLNWQYNYPSTASQTNHCPRASSQPTVSGNTSLTTNHQYVSSGYPS LQNSFIKSGPSVPPLVNPPLPTTFQPGAPHGPPPAGGPPPVRALTPLTSSYRDVPQPLFNSAVNQEGITSNTNNGSMVVHSSYDEIEGGG LLATPQLTNKNPKMSRSVGYSYPSLPPGYQNTTPPGATGVPPSSLNYPSGPQAFTQTPLGANHLTTSMSGLSLQPEGLRVVNLLQERNML PSTPLKPPVPNLHEDIQKLNCNPELFRCTLTSIPQTQALLNKAKLPLGLLLHPFKDLVQLPVVTSSTIVRCRSCRTYINPFVSFLDQRRW KCNLCYRVNDVPEEFLYNPLTRVYGEPHRRPEVQNATIEFMAPSEYMLRPPQPPVYLFVFDVSHNAVETGYLNSVCQSLLDNLDLLPGNT RTKIGFITFDSTIHFYGLQESLSQPQMLIVSDIEDVFIPMPENLLVNLNESKEAFGFMSRVALQAEKMNHHPEWFNVYNKVQITLTSHDC -------------------------------------------------------------- >80078_80078_3_SEC24A-PCBD2_SEC24A_chr5_134028347_ENST00000398844_PCBD2_chr5_134294730_ENST00000254908_length(transcript)=2840nt_BP=2067nt CCGGCCAGGGCCTCCCTCCTTCTCTCTAGGTTTGGCTGCCGCCTTCTAGCCGGGCGTTCGCGGCCCCGCCGGCCCGACTCTCAAGCCTCA GCTCCCAGGCTAGGCTGTGGCCGCCGGTGGCCTGGGGAGAGTGCGGCGCCATGCCTCGGGCTTAATGCGCCCCCCCCTCTTCTCCCAGTC TTCAGTCTTAAGTCGTTAGCCTCCTCCCTCCGCTTTCAGCAGTGGTCTTTCAGCTCTCTTCTTGTGCGCTGTTGTCGACCCCGACCAGCC CCTTCCAACCCAGTCATCATGTCCCAGCCGGGAATACCGGCCTCCGGCGGCGCCCCAGCCAGCCTCCAGGCCCAGAACGGAGCCGCCTTG GCCTCGGGGTCTCCCTACACCAACGGTCCTGTCCAAAATGCATTGCTGTCTTCACAAGAGTCAGTGAGCCAAGGATACAATTTCCAGCTT CCAGGATCCTACCCTCATCCAATACCAGCAAAGACTTTGAATCCAGTCTCTGGACAGTCTAACTATGGTGGTTCTCAGGGATCTGGGCAG ACTCTTAATAGACCACCTGTGGCCTCTAATCCAGTGACACCTTCGCTTCATAGTGGTCCTGCTCCCCGAATGCCATTACCTGCTTCTCAG AACCCAGCTACTACACCAATGCCTTCTAGTAGCTTTCTTCCTGAAGCCAACCTGCCACCACCTTTGAATTGGCAATATAACTATCCATCC ACAGCCTCACAAACAAACCATTGTCCTCGTGCATCATCCCAACCAACTGTATCTGGAAATACAAGTTTAACCACAAATCATCAATATGTT TCTTCTGGATATCCTTCACTTCAAAATAGCTTCATAAAGTCAGGTCCTTCTGTACCTCCCTTAGTGAATCCACCTCTGCCTACAACTTTT CAACCAGGAGCTCCTCATGGGCCCCCTCCAGCTGGAGGCCCACCCCCAGTGAGGGCCCTCACGCCCCTGACATCATCATATAGAGATGTA CCCCAGCCCTTATTTAATTCAGCTGTCAACCAAGAAGGTATTACATCAAATACCAATAACGGATCTATGGTGGTCCACAGTAGTTACGAC GAGATTGAAGGAGGTGGCTTATTGGCAACACCACAGCTTACTAACAAGAATCCCAAAATGAGCCGAAGTGTTGGATATTCATATCCCTCC TTACCACCTGGTTATCAGAACACAACACCACCTGGTGCAACTGGAGTACCACCCTCTTCCTTGAATTACCCAAGTGGGCCACAAGCCTTT ACTCAGACTCCCTTAGGTGCTAATCATTTAACCACAAGCATGAGTGGATTAAGTCTACAACCAGAGGGTCTAAGAGTTGTCAATCTTCTT CAAGAAAGAAACATGCTTCCGTCAACACCTTTGAAGCCTCCAGTTCCAAATTTGCATGAAGACATCCAGAAACTCAACTGTAACCCAGAG TTATTTCGATGCACGCTGACTAGCATTCCTCAGACGCAGGCCTTATTGAATAAAGCCAAACTTCCTTTGGGGCTGCTGCTTCATCCTTTC AAAGACTTAGTGCAATTGCCTGTGGTTACCTCCAGTACAATTGTGAGATGCCGTTCATGCAGGACGTACATCAATCCTTTCGTCAGCTTT CTTGATCAAAGGAGATGGAAGTGTAACTTATGTTATCGAGTCAATGATGTTCCTGAAGAATTCTTGTACAACCCTTTGACCAGAGTTTAT GGAGAACCTCACAGAAGACCAGAAGTTCAAAATGCTACTATTGAGTTTATGGCTCCTTCAGAATACATGTTACGACCACCTCAGCCTCCA GTGTATCTCTTTGTATTTGATGTGTCTCACAATGCAGTCGAAACTGGATACTTGAATTCAGTTTGCCAGAGTTTGTTAGACAATCTGGAT TTGCTTCCTGGCAACACTAGAACAAAAATTGGCTTCATAACATTTGACAGTACAATCCATTTCTACGGTCTTCAGGAAAGTCTCTCTCAA CCTCAGATGCTAATAGTTTCAGATATTGAAGATGTTTTTATACCTATGCCAGAGAACTTATTAGTAAACTTAAATGAAAGTAAAGAGGCA TTTGGCTTTATGTCCCGAGTTGCCCTACAAGCAGAGAAGATGAATCATCACCCAGAATGGTTCAATGTATACAACAAGGTCCAGATAACT CTCACCTCACATGACTGTGGTGAACTGACCAAAAAAGATGTGAAGCTGGCCAAGTTTATTGAAAAAGCAGCTGCTTCTGTGTGATTTCTT CCAAAATACATGTAAAATCTTGTACACATCTTAGCTGCAATGTATGTTGAAGGAAATTTATGTGAACAAATAGAGTTGTTCTTTTTCTCT TTTTTTTAAGACAGAGTGTTGCTCTGTCGCCCAGGCCAGAGTGCAGTGGTATGATCTCGGCTCACTGTAACCTCCGCCTCCCAGGTTCAG GTGATTCTCCTGCCTCAGCCTCCTGAGTAGCTGGGATTACAAGCACGTGTCACCACGCCTGGCTAATTTTTGTATTTTTAGTATAGACAG GGTTTTACCACGTTGGTCAGGCTGGTCTCGAACTCCTGACCTCGTGATCCGCCTGCCTCAGCCTCCCAAAGTGCTGGGATTACAGGCATG AGCCACCATGCCTGGCTGTTGAATTGTTCTTAAGGCATCATATCTAGAAGCAAAGAAAAAAGAAAAATAACAATTTAAGTTGTGTAAATT GTTTGCCTTTATATATTACATTTGGTAAAATCAGTGCTTAAATACGCAATGATTTAAACTGGAACCTGAGGTATTTTTCATGCTATCTAA >80078_80078_3_SEC24A-PCBD2_SEC24A_chr5_134028347_ENST00000398844_PCBD2_chr5_134294730_ENST00000254908_length(amino acids)=651AA_BP=0 MSQPGIPASGGAPASLQAQNGAALASGSPYTNGPVQNALLSSQESVSQGYNFQLPGSYPHPIPAKTLNPVSGQSNYGGSQGSGQTLNRPP VASNPVTPSLHSGPAPRMPLPASQNPATTPMPSSSFLPEANLPPPLNWQYNYPSTASQTNHCPRASSQPTVSGNTSLTTNHQYVSSGYPS LQNSFIKSGPSVPPLVNPPLPTTFQPGAPHGPPPAGGPPPVRALTPLTSSYRDVPQPLFNSAVNQEGITSNTNNGSMVVHSSYDEIEGGG LLATPQLTNKNPKMSRSVGYSYPSLPPGYQNTTPPGATGVPPSSLNYPSGPQAFTQTPLGANHLTTSMSGLSLQPEGLRVVNLLQERNML PSTPLKPPVPNLHEDIQKLNCNPELFRCTLTSIPQTQALLNKAKLPLGLLLHPFKDLVQLPVVTSSTIVRCRSCRTYINPFVSFLDQRRW KCNLCYRVNDVPEEFLYNPLTRVYGEPHRRPEVQNATIEFMAPSEYMLRPPQPPVYLFVFDVSHNAVETGYLNSVCQSLLDNLDLLPGNT RTKIGFITFDSTIHFYGLQESLSQPQMLIVSDIEDVFIPMPENLLVNLNESKEAFGFMSRVALQAEKMNHHPEWFNVYNKVQITLTSHDC -------------------------------------------------------------- >80078_80078_4_SEC24A-PCBD2_SEC24A_chr5_134028347_ENST00000398844_PCBD2_chr5_134294730_ENST00000512783_length(transcript)=7452nt_BP=2067nt CCGGCCAGGGCCTCCCTCCTTCTCTCTAGGTTTGGCTGCCGCCTTCTAGCCGGGCGTTCGCGGCCCCGCCGGCCCGACTCTCAAGCCTCA GCTCCCAGGCTAGGCTGTGGCCGCCGGTGGCCTGGGGAGAGTGCGGCGCCATGCCTCGGGCTTAATGCGCCCCCCCCTCTTCTCCCAGTC TTCAGTCTTAAGTCGTTAGCCTCCTCCCTCCGCTTTCAGCAGTGGTCTTTCAGCTCTCTTCTTGTGCGCTGTTGTCGACCCCGACCAGCC CCTTCCAACCCAGTCATCATGTCCCAGCCGGGAATACCGGCCTCCGGCGGCGCCCCAGCCAGCCTCCAGGCCCAGAACGGAGCCGCCTTG GCCTCGGGGTCTCCCTACACCAACGGTCCTGTCCAAAATGCATTGCTGTCTTCACAAGAGTCAGTGAGCCAAGGATACAATTTCCAGCTT CCAGGATCCTACCCTCATCCAATACCAGCAAAGACTTTGAATCCAGTCTCTGGACAGTCTAACTATGGTGGTTCTCAGGGATCTGGGCAG ACTCTTAATAGACCACCTGTGGCCTCTAATCCAGTGACACCTTCGCTTCATAGTGGTCCTGCTCCCCGAATGCCATTACCTGCTTCTCAG AACCCAGCTACTACACCAATGCCTTCTAGTAGCTTTCTTCCTGAAGCCAACCTGCCACCACCTTTGAATTGGCAATATAACTATCCATCC ACAGCCTCACAAACAAACCATTGTCCTCGTGCATCATCCCAACCAACTGTATCTGGAAATACAAGTTTAACCACAAATCATCAATATGTT TCTTCTGGATATCCTTCACTTCAAAATAGCTTCATAAAGTCAGGTCCTTCTGTACCTCCCTTAGTGAATCCACCTCTGCCTACAACTTTT CAACCAGGAGCTCCTCATGGGCCCCCTCCAGCTGGAGGCCCACCCCCAGTGAGGGCCCTCACGCCCCTGACATCATCATATAGAGATGTA CCCCAGCCCTTATTTAATTCAGCTGTCAACCAAGAAGGTATTACATCAAATACCAATAACGGATCTATGGTGGTCCACAGTAGTTACGAC GAGATTGAAGGAGGTGGCTTATTGGCAACACCACAGCTTACTAACAAGAATCCCAAAATGAGCCGAAGTGTTGGATATTCATATCCCTCC TTACCACCTGGTTATCAGAACACAACACCACCTGGTGCAACTGGAGTACCACCCTCTTCCTTGAATTACCCAAGTGGGCCACAAGCCTTT ACTCAGACTCCCTTAGGTGCTAATCATTTAACCACAAGCATGAGTGGATTAAGTCTACAACCAGAGGGTCTAAGAGTTGTCAATCTTCTT CAAGAAAGAAACATGCTTCCGTCAACACCTTTGAAGCCTCCAGTTCCAAATTTGCATGAAGACATCCAGAAACTCAACTGTAACCCAGAG TTATTTCGATGCACGCTGACTAGCATTCCTCAGACGCAGGCCTTATTGAATAAAGCCAAACTTCCTTTGGGGCTGCTGCTTCATCCTTTC AAAGACTTAGTGCAATTGCCTGTGGTTACCTCCAGTACAATTGTGAGATGCCGTTCATGCAGGACGTACATCAATCCTTTCGTCAGCTTT CTTGATCAAAGGAGATGGAAGTGTAACTTATGTTATCGAGTCAATGATGTTCCTGAAGAATTCTTGTACAACCCTTTGACCAGAGTTTAT GGAGAACCTCACAGAAGACCAGAAGTTCAAAATGCTACTATTGAGTTTATGGCTCCTTCAGAATACATGTTACGACCACCTCAGCCTCCA GTGTATCTCTTTGTATTTGATGTGTCTCACAATGCAGTCGAAACTGGATACTTGAATTCAGTTTGCCAGAGTTTGTTAGACAATCTGGAT TTGCTTCCTGGCAACACTAGAACAAAAATTGGCTTCATAACATTTGACAGTACAATCCATTTCTACGGTCTTCAGGAAAGTCTCTCTCAA CCTCAGATGCTAATAGTTTCAGATATTGAAGATGTTTTTATACCTATGCCAGAGAACTTATTAGTAAACTTAAATGAAAGTAAAGAGGCA TTTGGCTTTATGTCCCGAGTTGCCCTACAAGCAGAGAAGATGAATCATCACCCAGAATGGTTCAATGTATACAACAAGGTCCAGATAACT CTCACCTCACATGACTGTGGTGAACTGACCAAAAAAGATGTGAAGCTGGCCAAGTTTATTGAAAAAGCAGCTGCTTCTGTGTGATTTCTT CCAAAATACATAAGTCTGAGAGGCTAAACTTGATGGCTGTGTTAACATATGTCACGTGTAGCACAGTGGAGAAAGCAGGATATGGCTCAT AATGACAGTGGTGAAGACCTGCGAATGAAGTTGCTAGTTATCACCTACATTAGGGTTTGACATAGGTCTATGTTATGGGTCGCTGCATCT GCTGGAACTCACAGACTTTACTATAGAGAATCAAAGATCCCGTATCCGAAGTCTATGGAAATGCTCATGGTGGTAAATTCCAACAGAATG AAACACCAAACTTGCTTAAAGTAACTCACGTTTCAATTTGAAAGAGATATTGTCAAAATTGGAGGCCCCCAGGTTCCTGTCTGTTCCAAA TCTTTGCATGATGACAGTGGTTTCTCTGATGTGGTAAGCTTTGGCTTTCTTCTGTTTTCTTTCTAAAAGATCACTGGAGTAGAGAGGAGT TAAACAGACATGACCTTTGACCTCTTGCATGACCTCCACAGATAGCAAACCGGGCCGACACATGGTTGACGATGTCCTTTTCTACAATGA AGTTAATGAAAGTTCTGAAAATAGTGATTACTTTCTGACATTGATAGGATTTAGGAAACCTCTGGATAAATAGCTTAAGCATGGCTGTTT ATGTTTTTGCTATAGACAAAAAGCAGCAGCATGTACATTGTATTTGGACACAAGCCTGCCTCGGTTAATATATTGAACTATTGGACCACT AGGGTTAGTAGGGAGCGGTCTGTACACTTTCTGATTCAGCATTCAGAAACATTCTAGGTGGACTCTGTAGCTTTCAGTTTTGTAAAGTTA TCAGAAAAACATCGGGAGGGTTTGGCCATCATATGTGAGCTTTGTGTTTCAATGCCAGTTACTCAGGATTAGTAAATTAATGACTGTCCA GAGGACTTCAGGGTCACCAAGCTGCTGCACCTGCCATTGGCTGACTCTCCCCGGCTATCTGTGGCTGAGATGGTGCTGCTTAGGTCACGC AGAGCATGAGCTGCTGCTGAAAGGGCACAGGAGATGGCCCTTGGGCTTCTCATCCCAGGATGCCTGCCCTGCCCACCAATCCATGAGAAG ATATGTATGATTTCAGTAGGCCCTGGATCAGCTTGTCACCTCTGGTTTCCTGTTTGCTTTCCACTCACTCAGCTGGAGTTTCATTTCCAG ACTAAAGTCTTCATCATTGGCTTCAGAAACAGCATTCATCTGTGGCTGTGCTGATGTAGTACACCAAGAACAACTGGGCTCTTCTCTGTC ACTTTCAGTGGGCTACCTTCCCTCACCTCTCCAAGCAGCATGAAAGAATTCTTTACATTTTTAATCTCTTTTTTGTTTTTCCCTGAAAGT ATGCTTTGGTGCTTAAAGAGAGAAGTCACAAAAGTATACTACTGAGTTTCCTGGAGATGAAATCCTGTTGTCCCTAGCTATGTGAATGAG CACAGGGATCCCTGATGCCATTATTTTGTATATTCATACGGCACACACTTACTGAGGGCCTTCTGTGTGCCCTAGGGGATTGAGCACAGT GACATATCAGGGCAGGTAGAAACAGATGGAGAGCTGATGCGGGCTGTCTTAGAGCAGCTGCCCCAGGAGGCCCCTGTGGATGGATGTTGG GCAGGAGCCCTGAGACGTTAGGGGCATATAACTAAAGGACATAGCAGGAGTTATAGGAGGAGCTGATCCCTGAGGGAAACAATGAAGACG GAGAAGATGGGGCTAAAGTTTGAATTGTGGGGACATTAATCACAGTGATTCTTAAAACTTTGCTGTTGATGATTTTAAATGGAGAAAATG AGTACGTAAGATGTTATTTCCCAGTTCAGTATATTGGTTGCCCACAAAGTATTTTCCTACCATGAATGGTCATATATACTTGTTGTAGAA TACCAGGGACAGCAGAGATGGTGGGGTAGTTACTTCCTTTTCTTACAGCCCAAGAACTTTGGTGTCCAGGAGATTGACCAATTTAGCCAC TGAGCATTTAATACAACACAGGGCTACCCAGATCCCACTGTCCTGATTTGCCCTGAAAGCCAAAGGAGTTAGGAGAAGGTGAGTGGGGAG AATATATTAATCCTGAGAGTTGAACAGAGCAAAAATCCCTATTACTTTTGTACTTAAAACATCTCTGCCACATGTGCTCACTCTTTATAT TCTGTTTAGGTGGTTTATATGTGCACATCCCATCCTATGCCTGCAGTTAGCCAACTCAGGGTTTATATTGCCTCCTTTCTTTTTTTCTTT TTTTTTTTTTTTTTAAGAGATGGGGTCTCATTCTATCATGCAGACTGGAGTGCAGTGGTGTGATCACAGCTCATTGTAACCTCCAACGCC TGGACTAAAGTGATCCTCCTACCTTGGCCTCTCTGGTAGCTGGGACTACAGGTGCATGCCACCACACCCACCTAATTTTTTTTATTTTTA TTTTTTGTAGAGACAGTCTCACTATCTTGCTCAGGCTAGTCCTGAACTCCTGGGCTCAAGTTATCTTGCTGCCTCAGCCTCCCATGGGTA ATTTTTATTTCCTTTTTTTTTTTTTTTGGAGATGGAGTTTCGCTCTTGTCGCCCAGGCTGGAGTGCAATGGCACGATCTTGGCTCACTGC AGTCTCCACCTCCTGGGTTCAAGTGATTCTCCATCCTCAGCCTCCTGAGTAGCTGAGATTACAGGCAACTGCCACCATGCGCGGCTAATT TATGTATTTTTTTTTAGTAAGAGATGGGGTTTCACCATGTTGGCCAGACTAGTCTTAAACTCCTGACCTCAAGCGACCTGCCTGCCTTGG CCTCCCAAAGTGCTGGGATTACAGGCATGAGCCGCTATGCCTCGTCGCTGATTTTTATTTCTTATTTTTTTTTTAGAGATGGGGGTCTCA CTATGTTGCTCAGGCTGATCTCAAACTCCTGGCCTCAAGTGATCCTCCCACCTTAGCCTCCCAAGTTGCTGGGATTATAAGTGTGAGCCA CTATCCCTACCTCACTATTACCTTCTTTGCTTCTCTTGTTTTCTTTTGTTCTAAGTCAAACCCATCACAATCTTTTCTTGTCCTTCCAGG TGTTTTCCAGTGCTGTGCCCTGGATGTGCTCTCTTTCTCTTAGAGCCCAGAGAACTTGCTTTTCCCCCTTATATATGACCCTTAACTTTT TCTAACACATTATTAAGGGCCTGTGTCTATCAGCTGGGGGCACTTCTTGAAGGGAGGGCCTTTGTGTGGTCTGTTTCTAGTGACTTCCAG CTTTAACCCAGAGCCTCATGATTGCTGGGTGCCCATAGCCTTTTTGCTGAATGGAGGCACTCAGTCTCCTTGGGAAGAGAGAATCCATGA TAGACCCACTTGGGAGCTCCCCACTTCAGGGGCCTACACACTGGTAATGCAACAGAATGCCCAAGAGTGACCTCATAAAGCAAGGATTCC CTTCGTGGCCCCTTCTCTGCTGCCTCTCAGAATCCAGACGCTAAGGAAAATCCCTAAGCAGAGATTTTCTGTTGGATGCTAAAAGCAAGG AATAAAAGTTGAAAATTTGGAAAATGTCTCAACACCGTCACCAGCGCCACTCGAGAGTCATTTCTAGTTCACCAGTTGACACTACATCGG TGGGATTTTGCCCAACATTCAAGAAATTTAAGTAAATATTATCTATCTCCATTGCCTGTTAAGAAATGTGCTAGTAGAAGTGTGAGGGCA GGGTGTCAGTGTTCTCTCAGCCTCTTCCCTCAGATACTCGTCTGCTTACCAAAATAAGTTGCATGTCCTTGACAATCTGGTTTCTATGAT TGGTGAGGCTGGCATGCTATTACCTTTATGTGCCCTGTAGACTTGAATGACCAGTTTGACCAGTTTGACTGTTAGATAATCTGAAGGCTT TTCTCTTTTTTTATAATAGACCCCATCTCAAATCAGATAATGAAAATTACATATCTTGATATATTAGAAAAGTATATACATTCTGGCTGG GCACGGTGGCTCACACCTGTAATCCCTGCACTTTGAGAGGCTGGGGCGGATCACTTGAGGTCAGGAGTTTGAGACCAGCCTGGCCAACGT GGCGAAACCCCATCTCTACTAAAAATACACAGATTAGCCCGGAGTGATGGTGTGCACCTGTTGTCCCAGCTACTCAGGATGCTGAGGCAG GAGAATCCCTTTAACCTGGGGGGCGAAGGTTGCAGTGAGCCAAGATTGCACCACTGCACTCCAGCCTGGGTGACAGAACGAGACTCTGTC TCAGAAAAAAAAAAAAAGAAAAGGAAAAAGAAAAATATATATTCTATATTTTTTTAACTTATGAGAATGTGTTCATTTCATTTGTAACAT ATAATGGGAAACAGTAATACGTACTCTGAGAAAAATTGCAAAGCACAGATAAATGGAAATAAACAGGAAAAAGAATCACCTATAACCTCA CCATCCATAGACAGACACTGTTAAAATTTTGGCATATTTCCTGCTGATTTTTTCTACTGCTGATTTTTGCACAGGTGAGATAATTTTGAA CAGAGAATTTTGTATCTTTGGTTTTTGTGTTTTGCTGCACACAAAAACAAAAGATATAAAAATGGATCATAAACATTTTTCTAAATCCTG AAAAATGCATAGACATATTTTAGTGCCTGTATTTCACAAGATGGACATACCATAATTTACTTACACAGTCCTTTTTGTTAGATGTTTAAG TTGTTTTCAAGCTTCTCAGTGCTGGAAAAAATACTGAGATAGACATGTTTAGTTGAAGTTATTTCATTTCAGGTTATATTATCTTGGGTC AGAGAATGAATGGTTCTCAGGCTTTTCAAAAGAGCTGGTCAGTTTTTATGCCTCTGGCAGTTTTTGAGAGTGCTCAATCATACTACACTG TTGCCAGCATTAGATCTTATCACATTTAAGTCATTGCTAATTTTATAAACAAAAACAATGGTTTTACTTTGCATCTCCCTGATTGGTATT GCTGTAGAACATATTTGGAGAAGTTTGTTTGTCTTTGGTGTTTATTTCATGAATAGATTGTGTGCCCATTTTCTCTTGGGGTATTCAGTT TTTTATTACTGATGTGAGCATGTGTATGGGTGATTATTTGATGATTATCAGTTTTGCTTAGTAGACTGGCAATATTTAGTCTTGCTGTCA >80078_80078_4_SEC24A-PCBD2_SEC24A_chr5_134028347_ENST00000398844_PCBD2_chr5_134294730_ENST00000512783_length(amino acids)=651AA_BP=0 MSQPGIPASGGAPASLQAQNGAALASGSPYTNGPVQNALLSSQESVSQGYNFQLPGSYPHPIPAKTLNPVSGQSNYGGSQGSGQTLNRPP VASNPVTPSLHSGPAPRMPLPASQNPATTPMPSSSFLPEANLPPPLNWQYNYPSTASQTNHCPRASSQPTVSGNTSLTTNHQYVSSGYPS LQNSFIKSGPSVPPLVNPPLPTTFQPGAPHGPPPAGGPPPVRALTPLTSSYRDVPQPLFNSAVNQEGITSNTNNGSMVVHSSYDEIEGGG LLATPQLTNKNPKMSRSVGYSYPSLPPGYQNTTPPGATGVPPSSLNYPSGPQAFTQTPLGANHLTTSMSGLSLQPEGLRVVNLLQERNML PSTPLKPPVPNLHEDIQKLNCNPELFRCTLTSIPQTQALLNKAKLPLGLLLHPFKDLVQLPVVTSSTIVRCRSCRTYINPFVSFLDQRRW KCNLCYRVNDVPEEFLYNPLTRVYGEPHRRPEVQNATIEFMAPSEYMLRPPQPPVYLFVFDVSHNAVETGYLNSVCQSLLDNLDLLPGNT RTKIGFITFDSTIHFYGLQESLSQPQMLIVSDIEDVFIPMPENLLVNLNESKEAFGFMSRVALQAEKMNHHPEWFNVYNKVQITLTSHDC -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for SEC24A-PCBD2 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for SEC24A-PCBD2 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for SEC24A-PCBD2 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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