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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:SEC61A1-DDX46 (FusionGDB2 ID:80127)

Fusion Gene Summary for SEC61A1-DDX46

check button Fusion gene summary
Fusion gene informationFusion gene name: SEC61A1-DDX46
Fusion gene ID: 80127
HgeneTgene
Gene symbol

SEC61A1

DDX46

Gene ID

29927

9879

Gene nameSEC61 translocon subunit alpha 1DEAD-box helicase 46
SynonymsHNFJ4|HSEC61|SEC61|SEC61APRPF5|Prp5
Cytomap

3q21.3

5q31.1

Type of geneprotein-codingprotein-coding
Descriptionprotein transport protein Sec61 subunit alpha isoform 1SEC61 translocon alpha 1 subunitSec61 alpha 1 subunitSec61 alpha-1protein transport protein SEC61 alpha subunitprotein transport protein Sec61 subunit alphasec61 homologprobable ATP-dependent RNA helicase DDX46DEAD (Asp-Glu-Ala-Asp) box polypeptide 46DEAD box protein 46PRP5 homologPrp5-like DEAD-box proteinRNA helicase
Modification date2020031320200313
UniProtAcc.

Q7L014

Ensembl transtripts involved in fusion geneENST00000243253, ENST00000464451, 
ENST00000424880, ENST00000483956, 
ENST00000509178, ENST00000354283, 
ENST00000452510, 
Fusion gene scores* DoF score12 X 9 X 9=97211 X 9 X 6=594
# samples 1212
** MAII scorelog2(12/972*10)=-3.01792190799726
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(12/594*10)=-2.30742852519225
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SEC61A1 [Title/Abstract] AND DDX46 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointSEC61A1(127775683)-DDX46(134113264), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across SEC61A1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across DDX46 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-CD-A48C-01ASEC61A1chr3

127775683

+DDX46chr5

134113264

+


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Fusion Gene ORF analysis for SEC61A1-DDX46

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000243253ENST00000509178SEC61A1chr3

127775683

+DDX46chr5

134113264

+
5CDS-intronENST00000464451ENST00000509178SEC61A1chr3

127775683

+DDX46chr5

134113264

+
In-frameENST00000243253ENST00000354283SEC61A1chr3

127775683

+DDX46chr5

134113264

+
In-frameENST00000243253ENST00000452510SEC61A1chr3

127775683

+DDX46chr5

134113264

+
In-frameENST00000464451ENST00000354283SEC61A1chr3

127775683

+DDX46chr5

134113264

+
In-frameENST00000464451ENST00000452510SEC61A1chr3

127775683

+DDX46chr5

134113264

+
intron-3CDSENST00000424880ENST00000354283SEC61A1chr3

127775683

+DDX46chr5

134113264

+
intron-3CDSENST00000424880ENST00000452510SEC61A1chr3

127775683

+DDX46chr5

134113264

+
intron-3CDSENST00000483956ENST00000354283SEC61A1chr3

127775683

+DDX46chr5

134113264

+
intron-3CDSENST00000483956ENST00000452510SEC61A1chr3

127775683

+DDX46chr5

134113264

+
intron-intronENST00000424880ENST00000509178SEC61A1chr3

127775683

+DDX46chr5

134113264

+
intron-intronENST00000483956ENST00000509178SEC61A1chr3

127775683

+DDX46chr5

134113264

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000464451SEC61A1chr3127775683+ENST00000452510DDX46chr5134113264+55336151731001027
ENST00000464451SEC61A1chr3127775683+ENST00000354283DDX46chr5134113264+36886151730971026
ENST00000243253SEC61A1chr3127775683+ENST00000452510DDX46chr5134113264+54545361843021945
ENST00000243253SEC61A1chr3127775683+ENST00000354283DDX46chr5134113264+36095361843018944

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000464451ENST00000452510SEC61A1chr3127775683+DDX46chr5134113264+9.59E-050.99990416
ENST00000464451ENST00000354283SEC61A1chr3127775683+DDX46chr5134113264+0.0002396030.99976045
ENST00000243253ENST00000452510SEC61A1chr3127775683+DDX46chr5134113264+9.17E-050.9999083
ENST00000243253ENST00000354283SEC61A1chr3127775683+DDX46chr5134113264+0.0002998170.9997002

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Fusion Genomic Features for SEC61A1-DDX46


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
SEC61A1chr3127775683+DDX46chr5134113263+8.26E-091
SEC61A1chr3127775683+DDX46chr5134113263+8.26E-091

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for SEC61A1-DDX46


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:127775683/chr5:134113264)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.DDX46

Q7L014

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Plays an essential role in splicing, either prior to, or during splicing A complex formation. {ECO:0000269|PubMed:12234937}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSEC61A1chr3:127775683chr5:134113264ENST00000243253+5121_33117477.0Topological domainCytoplasmic
HgeneSEC61A1chr3:127775683chr5:134113264ENST00000243253+51254_76117477.0Topological domainLumenal
HgeneSEC61A1chr3:127775683chr5:134113264ENST00000243253+51297_117117477.0Topological domainCytoplasmic
HgeneSEC61A1chr3:127775683chr5:134113264ENST00000243253+51234_53117477.0TransmembraneHelical
HgeneSEC61A1chr3:127775683chr5:134113264ENST00000243253+51277_96117477.0TransmembraneHelical
TgeneDDX46chr3:127775683chr5:134113264ENST00000354283423202_2092041032.0Compositional biasNote=Poly-Asp
TgeneDDX46chr3:127775683chr5:134113264ENST00000452510423202_2092041033.0Compositional biasNote=Poly-Asp
TgeneDDX46chr3:127775683chr5:134113264ENST00000354283423403_5812041032.0DomainHelicase ATP-binding
TgeneDDX46chr3:127775683chr5:134113264ENST00000354283423592_7532041032.0DomainHelicase C-terminal
TgeneDDX46chr3:127775683chr5:134113264ENST00000452510423403_5812041033.0DomainHelicase ATP-binding
TgeneDDX46chr3:127775683chr5:134113264ENST00000452510423592_7532041033.0DomainHelicase C-terminal
TgeneDDX46chr3:127775683chr5:134113264ENST00000354283423372_4002041032.0MotifNote=Q motif
TgeneDDX46chr3:127775683chr5:134113264ENST00000354283423529_5322041032.0MotifNote=DEAD box
TgeneDDX46chr3:127775683chr5:134113264ENST00000452510423372_4002041033.0MotifNote=Q motif
TgeneDDX46chr3:127775683chr5:134113264ENST00000452510423529_5322041033.0MotifNote=DEAD box
TgeneDDX46chr3:127775683chr5:134113264ENST00000354283423416_4232041032.0Nucleotide bindingATP
TgeneDDX46chr3:127775683chr5:134113264ENST00000452510423416_4232041033.0Nucleotide bindingATP

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSEC61A1chr3:127775683chr5:134113264ENST00000243253+512139_144117477.0Topological domainLumenal
HgeneSEC61A1chr3:127775683chr5:134113264ENST00000243253+512166_172117477.0Topological domainCytoplasmic
HgeneSEC61A1chr3:127775683chr5:134113264ENST00000243253+512194_240117477.0Topological domainLumenal
HgeneSEC61A1chr3:127775683chr5:134113264ENST00000243253+512262_288117477.0Topological domainCytoplasmic
HgeneSEC61A1chr3:127775683chr5:134113264ENST00000243253+512310_354117477.0Topological domainLumenal
HgeneSEC61A1chr3:127775683chr5:134113264ENST00000243253+512376_420117477.0Topological domainCytoplasmic
HgeneSEC61A1chr3:127775683chr5:134113264ENST00000243253+512442_445117477.0Topological domainLumenal
HgeneSEC61A1chr3:127775683chr5:134113264ENST00000243253+512463_476117477.0Topological domainCytoplasmic
HgeneSEC61A1chr3:127775683chr5:134113264ENST00000424880+18139_1440357.0Topological domainLumenal
HgeneSEC61A1chr3:127775683chr5:134113264ENST00000424880+18166_1720357.0Topological domainCytoplasmic
HgeneSEC61A1chr3:127775683chr5:134113264ENST00000424880+18194_2400357.0Topological domainLumenal
HgeneSEC61A1chr3:127775683chr5:134113264ENST00000424880+181_330357.0Topological domainCytoplasmic
HgeneSEC61A1chr3:127775683chr5:134113264ENST00000424880+18262_2880357.0Topological domainCytoplasmic
HgeneSEC61A1chr3:127775683chr5:134113264ENST00000424880+18310_3540357.0Topological domainLumenal
HgeneSEC61A1chr3:127775683chr5:134113264ENST00000424880+18376_4200357.0Topological domainCytoplasmic
HgeneSEC61A1chr3:127775683chr5:134113264ENST00000424880+18442_4450357.0Topological domainLumenal
HgeneSEC61A1chr3:127775683chr5:134113264ENST00000424880+18463_4760357.0Topological domainCytoplasmic
HgeneSEC61A1chr3:127775683chr5:134113264ENST00000424880+1854_760357.0Topological domainLumenal
HgeneSEC61A1chr3:127775683chr5:134113264ENST00000424880+1897_1170357.0Topological domainCytoplasmic
HgeneSEC61A1chr3:127775683chr5:134113264ENST00000243253+512118_138117477.0TransmembraneHelical
HgeneSEC61A1chr3:127775683chr5:134113264ENST00000243253+512145_165117477.0TransmembraneHelical
HgeneSEC61A1chr3:127775683chr5:134113264ENST00000243253+512173_193117477.0TransmembraneHelical
HgeneSEC61A1chr3:127775683chr5:134113264ENST00000243253+512241_261117477.0TransmembraneHelical
HgeneSEC61A1chr3:127775683chr5:134113264ENST00000243253+512289_309117477.0TransmembraneHelical
HgeneSEC61A1chr3:127775683chr5:134113264ENST00000243253+512355_375117477.0TransmembraneHelical
HgeneSEC61A1chr3:127775683chr5:134113264ENST00000243253+512421_441117477.0TransmembraneHelical
HgeneSEC61A1chr3:127775683chr5:134113264ENST00000243253+512446_462117477.0TransmembraneHelical
HgeneSEC61A1chr3:127775683chr5:134113264ENST00000424880+18118_1380357.0TransmembraneHelical
HgeneSEC61A1chr3:127775683chr5:134113264ENST00000424880+18145_1650357.0TransmembraneHelical
HgeneSEC61A1chr3:127775683chr5:134113264ENST00000424880+18173_1930357.0TransmembraneHelical
HgeneSEC61A1chr3:127775683chr5:134113264ENST00000424880+18241_2610357.0TransmembraneHelical
HgeneSEC61A1chr3:127775683chr5:134113264ENST00000424880+18289_3090357.0TransmembraneHelical
HgeneSEC61A1chr3:127775683chr5:134113264ENST00000424880+1834_530357.0TransmembraneHelical
HgeneSEC61A1chr3:127775683chr5:134113264ENST00000424880+18355_3750357.0TransmembraneHelical
HgeneSEC61A1chr3:127775683chr5:134113264ENST00000424880+18421_4410357.0TransmembraneHelical
HgeneSEC61A1chr3:127775683chr5:134113264ENST00000424880+18446_4620357.0TransmembraneHelical
HgeneSEC61A1chr3:127775683chr5:134113264ENST00000424880+1877_960357.0TransmembraneHelical
TgeneDDX46chr3:127775683chr5:134113264ENST00000354283423152_1972041032.0Coiled coilOntology_term=ECO:0000255
TgeneDDX46chr3:127775683chr5:134113264ENST00000452510423152_1972041033.0Coiled coilOntology_term=ECO:0000255
TgeneDDX46chr3:127775683chr5:134113264ENST000003542834233_1032041032.0Compositional biasNote=Arg-rich
TgeneDDX46chr3:127775683chr5:134113264ENST000004525104233_1032041033.0Compositional biasNote=Arg-rich


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Fusion Gene Sequence for SEC61A1-DDX46


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>80127_80127_1_SEC61A1-DDX46_SEC61A1_chr3_127775683_ENST00000243253_DDX46_chr5_134113264_ENST00000354283_length(transcript)=3609nt_BP=536nt
AGCGATCCGAGGCCCGGCCCCGGCCCCGCCCCGCGCCGCGCCGCGCCGCTTGCCGCCGGGCTAGCACTGACGTGTCTCTCGGCGGAGCTG
CTGTGCAGTGGAACGCGCTGGGCCGCGGGCAGCGTCGCCTCACGCGGAGCAGAGCTGAGCTGAAGCGGGACCCGGAGCCCGAGCAGCCGC
CGCCATGGCAATCAAATTTCTGGAAGTCATCAAGCCCTTCTGTGTCATCCTGCCGGAAATTCAGAAGCCAGAGAGGAAGATTCAGTTTAA
GGAGAAAGTGCTGTGGACCGCTATCACCCTCTTTATCTTCTTAGTGTGCTGCCAGATTCCCCTGTTTGGGATCATGTCTTCAGATTCAGC
TGACCCTTTCTATTGGATGAGAGTGATTCTAGCCTCTAACAGAGGCACATTGATGGAGCTAGGGATCTCTCCTATTGTCACGTCTGGCCT
TATAATGCAACTCTTGGCTGGCGCCAAGATAATTGAAGTTGGTGACACCCCAAAAGACCGAGCTCTCTTCAACGGAGCCCAAAAGTATGA
CGAAGATGATCCTGCAGAAGCTGAAAAGGAGGGAAATGAAATGGAGGGTGAGGAGTTAGATCCATTAGATGCTTACATGGAAGAAGTGAA
AGAGGAAGTAAAAAAATTTAACATGAGAAGTGTAAAAGGTGGTGGGGGAAATGAAAAGAAGTCTGGGCCAACGGTCACAAAAGTTGTCAC
TGTTGTGACAACCAAAAAAGCAGTTGTGGATTCTGATAAGAAGAAAGGTGAGCTGATGGAGAATGACCAGGATGCCATGGAGTATTCTTC
AGAGGAGGAAGAAGTTGATCTTCAGACAGCCCTTACAGGGTATCAAACAAAACAGCGAAAGCTTCTAGAACCAGTTGATCATGGAAAAAT
TGAGTATGAGCCATTTAGGAAAAACTTCTATGTTGAAGTTCCAGAACTAGCAAAAATGTCTCAAGAAGAGGTAAATGTGTTTCGATTGGA
AATGGAGGGCATTACAGTTAAAGGAAAAGGTTGCCCCAAACCAATTAAATCCTGGGTCCAGTGTGGAATTTCCATGAAGATCTTAAATTC
CCTCAAGAAGCATGGCTATGAAAAGCCCACGCCCATCCAAACCCAAGCTATTCCTGCTATAATGTCTGGACGAGATTTGATTGGCATTGC
CAAAACAGGAAGTGGAAAGACCATTGCTTTTCTGTTGCCCATGTTTAGACACATCATGGATCAGAGGTCATTAGAGGAAGGAGAGGGGCC
AATAGCTGTCATCATGACTCCAACTCGAGAACTGGCTTTACAGATTACTAAAGAGTGTAAGAAGTTTTCCAAGACTTTGGGACTTAGAGT
GGTCTGTGTTTACGGAGGAACAGGAATCAGTGAGCAGATTGCTGAGCTGAAAAGAGGTGCTGAAATTATTGTTTGCACACCTGGTCGAAT
GATTGACATGTTAGCCGCTAACAGTGGTCGGGTCACAAATCTTCGAAGAGTGACATATGTTGTTTTAGATGAAGCAGACAGAATGTTTGA
CATGGGTTTTGAACCCCAGGTCATGCGCATCGTGGATAATGTTCGTCCTGATCGACAGACGGTTATGTTTTCAGCTACTTTCCCCAGAGC
TATGGAGGCTTTGGCTCGCAGGATCCTCAGTAAACCTATTGAAGTACAAGTTGGAGGCAGGAGTGTGGTTTGCTCAGATGTGGAGCAACA
AGTGATTGTGATTGAAGAAGAAAAGAAATTCTTGAAGTTACTTGAGCTTCTAGGCCATTATCAAGAGTCAGGATCTGTCATTATATTTGT
GGATAAGCAGGAACATGCTGATGGTCTTCTTAAGGATTTAATGAGAGCATCTTATCCTTGCATGTCTCTTCATGGAGGCATTGATCAATA
TGACAGAGATAGCATCATAAATGACTTTAAGAATGGGACCTGCAAACTTCTTGTGGCTACCTCTGTTGCTGCCCGAGGTCTAGATGTGAA
ACATCTGATTCTTGTAGTAAATTATAGCTGCCCCAACCATTATGAGGATTATGTACACAGAGCAGGGCGGACTGGAAGAGCAGGAAACAA
GGGTTATGCTTATACTTTTATCACAGAGGATCAAGCTCGCTATGCTGGTGACATAATTAAAGCTCTTGAATTGTCAGGGACTGCAGTACC
TCCTGATTTAGAGAAACTGTGGAGTGATTTCAAAGATCAGCAGAAAGCTGAGGGGAAAATAATTAAAAAGAGTAGTGGGTTCTCTGGTAA
GGGATTCAAGTTTGATGAAACAGAACAAGCTTTGGCTAATGAGAGGAAGAAGTTACAAAAAGCAGCTCTTGGTCTACAAGATTCAGATGA
TGAGGATGCTGCAGTTGATATTGATGAGCAAATTGAAAGCATGTTTAATTCAAAGAAGAGAGTAAAGGATATGGCTGCTCCTGGAACATC
AAGTGTTCCTGCTCCAACTGCAGGAAATGCTGAGAAATTAGAAATTGCTAAGAGATTGGCTCTTAGAATCAATGCCCAGAAGAATTTGGG
CATCGAGTCTCAGGATGTGATGCAGCAGGCCACCAATGCAATTCTTAGGGGTGGCACCATTCTGGCTCCCACTGTTTCTGCAAAAACCAT
TGCAGAACAACTTGCTGAAAAGATCAATGCCAAGCTCAATTATGTGCCGTTAGAGAAACAAGAAGAAGAGAGACAGGATGGTGGACAGAA
TGAATCTTTTAAGAGATATGAAGAAGAATTAGAGATCAATGACTTCCCACAGACTGCTAGGTGGAAAGTTACCTCTAAGGAAGCTCTGCA
GAGAATCAGTGAATACTCTGAAGCCGCAATTACAATCAGAGGAACCTACTTCCCTCCTGGCAAAGAACCCAAGGAAGGCGAGCGGAAGAT
TTACTTGGCAATTGAAAGTGCCAATGAACTGGCTGTGCAGAAAGCAAAGGCAGAAATCACCAGGCTCATAAAAGAAGAGCTGATCCGGCT
GCAAAATTCATACCAACCAACAAATAAAGGAAGATACAAAGTCTTATAGACATCCGGAAAAAAGATTTTTACCTGTGCTGGTCTATGATG
TATGTGGCAGTTGCTGTCTGCAGTTTACAATGTATTGTAAATGAAGATTTTTTAAATTCTATCTTGCTGATTTTTTTTAAATATAAGAAA
CTGGTACTTGGTAAAGAAATCTGTCCGTAAGTACCCCCACAATCAGTCAAACTATATTTAAAGCCAGCCTGTTTTCAGAGTATGATGTCC
TTTAATGTAAACTCAAATATCAATATTTTAAATGTCCGGATAATATTCTAGAGGTTTAAAAAATGGAAATATTTGAACTTTCTATTGAAG
ACAATAAAGTACACAAGTCGTTAAGGGGCTATTCACTTTATCCTGTACTTTCAATGAAATTGTGATCATTTCCTAAGAAAAGGTAAAATT
CACTATCATATTTTGTGTCCCCACCTTGATGTTACATGACTCTGGAACAATATGAACTGGATTTAAGAATGTTATAATAGAAGTCTTACA
AAATGGGTTGAGAGTTTTTGTTTCAATTTTTATCATCATAAATGGGCAAAAAGTAGTTGGACTAATTTCGGTTTTTATACAAGTAAAGAT

>80127_80127_1_SEC61A1-DDX46_SEC61A1_chr3_127775683_ENST00000243253_DDX46_chr5_134113264_ENST00000354283_length(amino acids)=944AA_BP=118
MAIKFLEVIKPFCVILPEIQKPERKIQFKEKVLWTAITLFIFLVCCQIPLFGIMSSDSADPFYWMRVILASNRGTLMELGISPIVTSGLI
MQLLAGAKIIEVGDTPKDRALFNGAQKYDEDDPAEAEKEGNEMEGEELDPLDAYMEEVKEEVKKFNMRSVKGGGGNEKKSGPTVTKVVTV
VTTKKAVVDSDKKKGELMENDQDAMEYSSEEEEVDLQTALTGYQTKQRKLLEPVDHGKIEYEPFRKNFYVEVPELAKMSQEEVNVFRLEM
EGITVKGKGCPKPIKSWVQCGISMKILNSLKKHGYEKPTPIQTQAIPAIMSGRDLIGIAKTGSGKTIAFLLPMFRHIMDQRSLEEGEGPI
AVIMTPTRELALQITKECKKFSKTLGLRVVCVYGGTGISEQIAELKRGAEIIVCTPGRMIDMLAANSGRVTNLRRVTYVVLDEADRMFDM
GFEPQVMRIVDNVRPDRQTVMFSATFPRAMEALARRILSKPIEVQVGGRSVVCSDVEQQVIVIEEEKKFLKLLELLGHYQESGSVIIFVD
KQEHADGLLKDLMRASYPCMSLHGGIDQYDRDSIINDFKNGTCKLLVATSVAARGLDVKHLILVVNYSCPNHYEDYVHRAGRTGRAGNKG
YAYTFITEDQARYAGDIIKALELSGTAVPPDLEKLWSDFKDQQKAEGKIIKKSSGFSGKGFKFDETEQALANERKKLQKAALGLQDSDDE
DAAVDIDEQIESMFNSKKRVKDMAAPGTSSVPAPTAGNAEKLEIAKRLALRINAQKNLGIESQDVMQQATNAILRGGTILAPTVSAKTIA
EQLAEKINAKLNYVPLEKQEEERQDGGQNESFKRYEEELEINDFPQTARWKVTSKEALQRISEYSEAAITIRGTYFPPGKEPKEGERKIY

--------------------------------------------------------------
>80127_80127_2_SEC61A1-DDX46_SEC61A1_chr3_127775683_ENST00000243253_DDX46_chr5_134113264_ENST00000452510_length(transcript)=5454nt_BP=536nt
AGCGATCCGAGGCCCGGCCCCGGCCCCGCCCCGCGCCGCGCCGCGCCGCTTGCCGCCGGGCTAGCACTGACGTGTCTCTCGGCGGAGCTG
CTGTGCAGTGGAACGCGCTGGGCCGCGGGCAGCGTCGCCTCACGCGGAGCAGAGCTGAGCTGAAGCGGGACCCGGAGCCCGAGCAGCCGC
CGCCATGGCAATCAAATTTCTGGAAGTCATCAAGCCCTTCTGTGTCATCCTGCCGGAAATTCAGAAGCCAGAGAGGAAGATTCAGTTTAA
GGAGAAAGTGCTGTGGACCGCTATCACCCTCTTTATCTTCTTAGTGTGCTGCCAGATTCCCCTGTTTGGGATCATGTCTTCAGATTCAGC
TGACCCTTTCTATTGGATGAGAGTGATTCTAGCCTCTAACAGAGGCACATTGATGGAGCTAGGGATCTCTCCTATTGTCACGTCTGGCCT
TATAATGCAACTCTTGGCTGGCGCCAAGATAATTGAAGTTGGTGACACCCCAAAAGACCGAGCTCTCTTCAACGGAGCCCAAAAGTATGA
CGAAGATGATCCTGCAGAAGCTGAAAAGGAGGGAAATGAAATGGAGGGTGAGGAGTTAGATCCATTAGATGCTTACATGGAAGAAGTGAA
AGAGGAAGTAAAAAAATTTAACATGAGAAGTGTAAAAGGTGGTGGGGGAAATGAAAAGAAGTCTGGGCCAACGGTCACAAAAGTTGTCAC
TGTTGTGACAACCAAAAAAGCAGTTGTGGATTCTGATAAGAAGAAAGGTGAGCTGATGGAGAATGACCAGGATGCCATGGAGTATTCTTC
AGAGGAGGAAGAAGTTGATCTTCAGACAGCCCTTACAGGGTATCAAACAAAACAGCGAAAGCTTCTAGAACCAGTTGATCATGGAAAAAT
TGAGTATGAGCCATTTAGGAAAAACTTCTATGTTGAAGTTCCAGAACTAGCAAAAATGTCTCAAGAAGAGGTAAATGTGTTTCGATTGGA
AATGGAGGGCATTACAGTTAAAGGAAAAGGTTGCCCCAAACCAATTAAATCCTGGGTCCAGTGTGGAATTTCCATGAAGATCTTAAATTC
CCTCAAGAAGCATGGCTATGAAAAGCCCACGCCCATCCAAACCCAAGCTATTCCTGCTATAATGTCTGGACGAGATTTGATTGGCATTGC
CAAAACAGGAAGTGGAAAGACCATTGCTTTTCTGTTGCCCATGTTTAGACACATCATGGATCAGAGGTCATTAGAGGAAGGAGAGGGGCC
AATAGCTGTCATCATGACTCCAACTCGAGAACTGGCTTTACAGATTACTAAAGAGTGTAAGAAGTTTTCCAAGACTTTGGGACTTAGAGT
GGTCTGTGTTTACGGAGGAACAGGAATCAGTGAGCAGATTGCTGAGCTGAAAAGAGGTGCTGAAATTATTGTTTGCACACCTGGTCGAAT
GATTGACATGTTAGCCGCTAACAGTGGTCGGGTCACAAATCTTCGAAGAGTGACATATGTTGTTTTAGATGAAGCAGACAGAATGTTTGA
CATGGGTTTTGAACCCCAGGTCATGCGCATCGTGGATAATGTTCGTCCTGATCGACAGACGGTTATGTTTTCAGCTACTTTCCCCAGAGC
TATGGAGGCTTTGGCTCGCAGGATCCTCAGTAAACCTATTGAAGTACAAGTTGGAGGCAGGAGTGTGGTTTGCTCAGATGTGGAGCAACA
AGTGATTGTGATTGAAGAAGAAAAGAAATTCTTGAAGTTACTTGAGCTTCTAGGCCATTATCAAGAGTCAGGATCTGTCATTATATTTGT
GGATAAGCAGGAACATGCTGATGGTCTTCTTAAGGATTTAATGAGAGCATCTTATCCTTGCATGTCTCTTCATGGAGGCATTGATCAATA
TGACAGAGATAGCATCATAAATGACTTTAAGAATGGGACCTGCAAACTTCTTGTGGCTACCTCTGTTGCTGCCCGAGGTCTAGATGTGAA
ACATCTGATTCTTGTAGTAAATTATAGCTGCCCCAACCATTATGAGGATTATGTACACAGAGCAGGGCGGACTGGAAGAGCAGGAAACAA
GGGTTATGCTTATACTTTTATCACAGAGGATCAAGCTCGCTATGCTGGTGACATAATTAAAGCTCTTGAATTGTCAGGGACTGCAGTACC
TCCTGATTTAGAGAAACTGTGGAGTGATTTCAAAGATCAGCAGAAAGCTGAGGGGAAAATAATTAAAAAGAGTAGTGGGTTCTCTGGTAA
GGGATTCAAGTTTGATGAAACAGAACAAGCTTTGGCTAATGAGAGGAAGAAGTTACAAAAAGCAGCTCTTGGTCTACAAGATTCAGATGA
TGAGGATGCTGCAGTTGATATTGATGAGCAAATTGAAAGCATGTTTAATTCAAAGAAGAGAGTAAAGGATATGGCTGCTCCTGGAACATC
AAGTGTTCCTGCTCCAACTGCAGGAAATGCTGAGAAATTAGAAATTGCTAAGAGATTGGCTCTTAGAATCAATGCCCAGAAGAATTTGGG
CATCGAGTCTCAGGTAGATGTGATGCAGCAGGCCACCAATGCAATTCTTAGGGGTGGCACCATTCTGGCTCCCACTGTTTCTGCAAAAAC
CATTGCAGAACAACTTGCTGAAAAGATCAATGCCAAGCTCAATTATGTGCCGTTAGAGAAACAAGAAGAAGAGAGACAGGATGGTGGACA
GAATGAATCTTTTAAGAGATATGAAGAAGAATTAGAGATCAATGACTTCCCACAGACTGCTAGGTGGAAAGTTACCTCTAAGGAAGCTCT
GCAGAGAATCAGTGAATACTCTGAAGCCGCAATTACAATCAGAGGAACCTACTTCCCTCCTGGCAAAGAACCCAAGGAAGGCGAGCGGAA
GATTTACTTGGCAATTGAAAGTGCCAATGAACTGGCTGTGCAGAAAGCAAAGGCAGAAATCACCAGGCTCATAAAAGAAGAGCTGATCCG
GCTGCAAAATTCATACCAACCAACAAATAAAGGAAGATACAAAGTCTTATAGACATCCGGAAAAAAGATTTTTACCTGTGCTGGTCTATG
ATGTATGTGGCAGTTGCTGTCTGCAGTTTACAATGTATTGTAAATGAAGATTTTTTAAATTCTATCTTGCTGATTTTTTTTAAATATAAG
AAACTGGTACTTGGTAAAGAAATCTGTCCGTAAGTACCCCCACAATCAGTCAAACTATATTTAAAGCCAGCCTGTTTTCAGAGTATGATG
TCCTTTAATGTAAACTCAAATATCAATATTTTAAATGTCCGGATAATATTCTAGAGGTTTAAAAAATGGAAATATTTGAACTTTCTATTG
AAGACAATAAAGTACACAAGTCGTTAAGGGGCTATTCACTTTATCCTGTACTTTCAATGAAATTGTGATCATTTCCTAAGAAAAGGTAAA
ATTCACTATCATATTTTGTGTCCCCACCTTGATGTTACATGACTCTGGAACAATATGAACTGGATTTAAGAATGTTATAATAGAAGTCTT
ACAAAATGGGTTGAGAGTTTTTGTTTCAATTTTTATCATCATAAATGGGCAAAAAGTAGTTGGACTAATTTCGGTTTTTATACAAGTAAA
GATTTAATAGTATAAGGATTTTTTTGCATTTCTTTACACTGAGTGTAAAACTCTACAAAGAGTTATAGTATTTACTACTTTGAGGTTTCC
CTCACAACTTCTGGCTCCATACCTAGCCCCTCTTTTATAATCTTCCTTAAAAGAAAGAGTGTAGCCTATAAATACTAAATATGATACCTT
TTCCTTCTAGAAAGTGTTTATTTATATATCTATACATGTTGTATGTACAAATATCCTACTACTTTTAATCTGATTTTTCTTCAGGATTAT
TGAGTAGGTTGTGAATTTTCTTTCTTAAAAATTGTAAAACATAATGGTACCCAAGTTTTAAACTTAGATGTGCTTCATCTTAGTGAAATT
TAATTCACAAGGAATCATAAATTGTGTTTTTGAGGCTGGGCGCAGTGACTCACACCTGTATCCCAGCAATTTGGGAGGCCGAGGTGGGCA
GATCACTTGAGGTCAGGAGTTCAAGACTAGCCTGGTCAACATGGTGAAACCCTGTCTCTACTAAAAATACAAAAATTAGTCGGCATGGTG
GTGGGTGGCTGTAATCCCAGCTACTCAGGAGGCTGAGGCAGAAGAATCTGAGCCAAGATAACACCATTGCACTCCAGCCTGGGCGACAGA
GTGAGACTATCTCAAAAATAAATAAATAAATAAATAAATAGTATTTTTGAGCCTTCAAGATACAGTTCCTGAATATTCTAATTTAAATTG
TTATAATTGGATTACCTAATATTCTTTTCAAGACTCCTGATGTATTAACTTCATGTTATTGTCACTTTTCAAAAAAGGAATTTTTTTCAG
GAGTTAAATAAAGTCAGTCTTTTATATCCAAGGGTTTCAAACCCACAGATTAAACCAACCACAGATCAAAAATAGAAAAAAAAAAAAAAA
GAAAAAAAGAATGTAAAATTTTAAAAATACAGTTTAACAGCTGTAAAAGTTTTACTATAACATTTACATTGTGTTAGGTATTTTAAGTAA
TTTAAAGGTTACAGTATACAGGCGGTTAAAGTATACAGGAGGATGTGCATCGGTTATATGCATATAGCAAGCCATTTCATATAAGAGGCT
TGAACATCCATGGATTTTGGTATAGAGGAGGGGTTTAAGGGGTGTCCTGCAATCAGTCCCCCTCTCATACCAAAGGATGACTGTATATTT
CTTAAATGAAGAGACTTTCATTCTTTAAATATTATTGACTTACAGTTTAAAAATAAATAAATAAAAGCATACTATAGTTGTAAAAACAAA
TAATTTTAATAGTATATTCAGTGGCTGAAGTGATAGGGAGTATTAATCATTATTTCTTCAGTATAAAGTTATTCTTCCTGAAAAAGTAAG
ATATACCTGGGAAATATTCTTGGATCCTTCACACATCCACTTAATTTCTTGAAGGAAGAAAACAGACAAAAGACATGTAACAACAGAAAC
AAATAAACCACTTACTGTAAAATTTCAGAAATTGTGGGCTCATTCCCTCCCTCTAGTTTATTTATTTGCTCATCTTTATCACCTAATGGT
AGTTTGTTTTCTTTGGTAGAGTATATGGCAGTCCCACATCGATGATAATTGGTGCTCCCTTCATCCAACTGGATCACTTTGAGATTCAGT
TTTACATCATTTTAGCATTTTGTTTGTATATCAGTTGTGATGAGCCACTGATAAAATTTTGTTCTAAAATGAAACATATTACTTTGTTAG
TACATTTTTTAGTGTCACACTGACTTTTAAAATTTGAATGATATATAGACTTTGTTTTTTTAATGCAATATGAATATTTGCTCATGTTTT

>80127_80127_2_SEC61A1-DDX46_SEC61A1_chr3_127775683_ENST00000243253_DDX46_chr5_134113264_ENST00000452510_length(amino acids)=945AA_BP=118
MAIKFLEVIKPFCVILPEIQKPERKIQFKEKVLWTAITLFIFLVCCQIPLFGIMSSDSADPFYWMRVILASNRGTLMELGISPIVTSGLI
MQLLAGAKIIEVGDTPKDRALFNGAQKYDEDDPAEAEKEGNEMEGEELDPLDAYMEEVKEEVKKFNMRSVKGGGGNEKKSGPTVTKVVTV
VTTKKAVVDSDKKKGELMENDQDAMEYSSEEEEVDLQTALTGYQTKQRKLLEPVDHGKIEYEPFRKNFYVEVPELAKMSQEEVNVFRLEM
EGITVKGKGCPKPIKSWVQCGISMKILNSLKKHGYEKPTPIQTQAIPAIMSGRDLIGIAKTGSGKTIAFLLPMFRHIMDQRSLEEGEGPI
AVIMTPTRELALQITKECKKFSKTLGLRVVCVYGGTGISEQIAELKRGAEIIVCTPGRMIDMLAANSGRVTNLRRVTYVVLDEADRMFDM
GFEPQVMRIVDNVRPDRQTVMFSATFPRAMEALARRILSKPIEVQVGGRSVVCSDVEQQVIVIEEEKKFLKLLELLGHYQESGSVIIFVD
KQEHADGLLKDLMRASYPCMSLHGGIDQYDRDSIINDFKNGTCKLLVATSVAARGLDVKHLILVVNYSCPNHYEDYVHRAGRTGRAGNKG
YAYTFITEDQARYAGDIIKALELSGTAVPPDLEKLWSDFKDQQKAEGKIIKKSSGFSGKGFKFDETEQALANERKKLQKAALGLQDSDDE
DAAVDIDEQIESMFNSKKRVKDMAAPGTSSVPAPTAGNAEKLEIAKRLALRINAQKNLGIESQVDVMQQATNAILRGGTILAPTVSAKTI
AEQLAEKINAKLNYVPLEKQEEERQDGGQNESFKRYEEELEINDFPQTARWKVTSKEALQRISEYSEAAITIRGTYFPPGKEPKEGERKI

--------------------------------------------------------------
>80127_80127_3_SEC61A1-DDX46_SEC61A1_chr3_127775683_ENST00000464451_DDX46_chr5_134113264_ENST00000354283_length(transcript)=3688nt_BP=615nt
AATCACACCGCCATGCTTTGCCCACAACAGTCTCCTCAACCTGTTCCCTCATTCCTTCTCGCCAGAATCTATCAAGGCTCGGCACAAAGG
TACTCTCCCAGGAGGCCTTCCTGAATTCTTCTGTGAGGCAGACTACTTCCCGAGCTGCCCCGGCCCTTCTCCGGCCAAGTCTCTCCAGAA
ACTCATCCCATTCGTTCTCAGATGGAAGGGGACCCACACCCACGACAAGCCTCCGGGTTTGCTTAATGACTCAGACAGCGAGGGTGCTCG
TCAAATTTCTGGAAGTCATCAAGCCCTTCTGTGTCATCCTGCCGGAAATTCAGAAGCCAGAGAGGAAGATTCAGTTTAAGGAGAAAGTGC
TGTGGACCGCTATCACCCTCTTTATCTTCTTAGTGTGCTGCCAGATTCCCCTGTTTGGGATCATGTCTTCAGATTCAGCTGACCCTTTCT
ATTGGATGAGAGTGATTCTAGCCTCTAACAGAGGCACATTGATGGAGCTAGGGATCTCTCCTATTGTCACGTCTGGCCTTATAATGCAAC
TCTTGGCTGGCGCCAAGATAATTGAAGTTGGTGACACCCCAAAAGACCGAGCTCTCTTCAACGGAGCCCAAAAGTATGACGAAGATGATC
CTGCAGAAGCTGAAAAGGAGGGAAATGAAATGGAGGGTGAGGAGTTAGATCCATTAGATGCTTACATGGAAGAAGTGAAAGAGGAAGTAA
AAAAATTTAACATGAGAAGTGTAAAAGGTGGTGGGGGAAATGAAAAGAAGTCTGGGCCAACGGTCACAAAAGTTGTCACTGTTGTGACAA
CCAAAAAAGCAGTTGTGGATTCTGATAAGAAGAAAGGTGAGCTGATGGAGAATGACCAGGATGCCATGGAGTATTCTTCAGAGGAGGAAG
AAGTTGATCTTCAGACAGCCCTTACAGGGTATCAAACAAAACAGCGAAAGCTTCTAGAACCAGTTGATCATGGAAAAATTGAGTATGAGC
CATTTAGGAAAAACTTCTATGTTGAAGTTCCAGAACTAGCAAAAATGTCTCAAGAAGAGGTAAATGTGTTTCGATTGGAAATGGAGGGCA
TTACAGTTAAAGGAAAAGGTTGCCCCAAACCAATTAAATCCTGGGTCCAGTGTGGAATTTCCATGAAGATCTTAAATTCCCTCAAGAAGC
ATGGCTATGAAAAGCCCACGCCCATCCAAACCCAAGCTATTCCTGCTATAATGTCTGGACGAGATTTGATTGGCATTGCCAAAACAGGAA
GTGGAAAGACCATTGCTTTTCTGTTGCCCATGTTTAGACACATCATGGATCAGAGGTCATTAGAGGAAGGAGAGGGGCCAATAGCTGTCA
TCATGACTCCAACTCGAGAACTGGCTTTACAGATTACTAAAGAGTGTAAGAAGTTTTCCAAGACTTTGGGACTTAGAGTGGTCTGTGTTT
ACGGAGGAACAGGAATCAGTGAGCAGATTGCTGAGCTGAAAAGAGGTGCTGAAATTATTGTTTGCACACCTGGTCGAATGATTGACATGT
TAGCCGCTAACAGTGGTCGGGTCACAAATCTTCGAAGAGTGACATATGTTGTTTTAGATGAAGCAGACAGAATGTTTGACATGGGTTTTG
AACCCCAGGTCATGCGCATCGTGGATAATGTTCGTCCTGATCGACAGACGGTTATGTTTTCAGCTACTTTCCCCAGAGCTATGGAGGCTT
TGGCTCGCAGGATCCTCAGTAAACCTATTGAAGTACAAGTTGGAGGCAGGAGTGTGGTTTGCTCAGATGTGGAGCAACAAGTGATTGTGA
TTGAAGAAGAAAAGAAATTCTTGAAGTTACTTGAGCTTCTAGGCCATTATCAAGAGTCAGGATCTGTCATTATATTTGTGGATAAGCAGG
AACATGCTGATGGTCTTCTTAAGGATTTAATGAGAGCATCTTATCCTTGCATGTCTCTTCATGGAGGCATTGATCAATATGACAGAGATA
GCATCATAAATGACTTTAAGAATGGGACCTGCAAACTTCTTGTGGCTACCTCTGTTGCTGCCCGAGGTCTAGATGTGAAACATCTGATTC
TTGTAGTAAATTATAGCTGCCCCAACCATTATGAGGATTATGTACACAGAGCAGGGCGGACTGGAAGAGCAGGAAACAAGGGTTATGCTT
ATACTTTTATCACAGAGGATCAAGCTCGCTATGCTGGTGACATAATTAAAGCTCTTGAATTGTCAGGGACTGCAGTACCTCCTGATTTAG
AGAAACTGTGGAGTGATTTCAAAGATCAGCAGAAAGCTGAGGGGAAAATAATTAAAAAGAGTAGTGGGTTCTCTGGTAAGGGATTCAAGT
TTGATGAAACAGAACAAGCTTTGGCTAATGAGAGGAAGAAGTTACAAAAAGCAGCTCTTGGTCTACAAGATTCAGATGATGAGGATGCTG
CAGTTGATATTGATGAGCAAATTGAAAGCATGTTTAATTCAAAGAAGAGAGTAAAGGATATGGCTGCTCCTGGAACATCAAGTGTTCCTG
CTCCAACTGCAGGAAATGCTGAGAAATTAGAAATTGCTAAGAGATTGGCTCTTAGAATCAATGCCCAGAAGAATTTGGGCATCGAGTCTC
AGGATGTGATGCAGCAGGCCACCAATGCAATTCTTAGGGGTGGCACCATTCTGGCTCCCACTGTTTCTGCAAAAACCATTGCAGAACAAC
TTGCTGAAAAGATCAATGCCAAGCTCAATTATGTGCCGTTAGAGAAACAAGAAGAAGAGAGACAGGATGGTGGACAGAATGAATCTTTTA
AGAGATATGAAGAAGAATTAGAGATCAATGACTTCCCACAGACTGCTAGGTGGAAAGTTACCTCTAAGGAAGCTCTGCAGAGAATCAGTG
AATACTCTGAAGCCGCAATTACAATCAGAGGAACCTACTTCCCTCCTGGCAAAGAACCCAAGGAAGGCGAGCGGAAGATTTACTTGGCAA
TTGAAAGTGCCAATGAACTGGCTGTGCAGAAAGCAAAGGCAGAAATCACCAGGCTCATAAAAGAAGAGCTGATCCGGCTGCAAAATTCAT
ACCAACCAACAAATAAAGGAAGATACAAAGTCTTATAGACATCCGGAAAAAAGATTTTTACCTGTGCTGGTCTATGATGTATGTGGCAGT
TGCTGTCTGCAGTTTACAATGTATTGTAAATGAAGATTTTTTAAATTCTATCTTGCTGATTTTTTTTAAATATAAGAAACTGGTACTTGG
TAAAGAAATCTGTCCGTAAGTACCCCCACAATCAGTCAAACTATATTTAAAGCCAGCCTGTTTTCAGAGTATGATGTCCTTTAATGTAAA
CTCAAATATCAATATTTTAAATGTCCGGATAATATTCTAGAGGTTTAAAAAATGGAAATATTTGAACTTTCTATTGAAGACAATAAAGTA
CACAAGTCGTTAAGGGGCTATTCACTTTATCCTGTACTTTCAATGAAATTGTGATCATTTCCTAAGAAAAGGTAAAATTCACTATCATAT
TTTGTGTCCCCACCTTGATGTTACATGACTCTGGAACAATATGAACTGGATTTAAGAATGTTATAATAGAAGTCTTACAAAATGGGTTGA

>80127_80127_3_SEC61A1-DDX46_SEC61A1_chr3_127775683_ENST00000464451_DDX46_chr5_134113264_ENST00000354283_length(amino acids)=1026AA_BP=200
MPTTVSSTCSLIPSRQNLSRLGTKVLSQEAFLNSSVRQTTSRAAPALLRPSLSRNSSHSFSDGRGPTPTTSLRVCLMTQTARVLVKFLEV
IKPFCVILPEIQKPERKIQFKEKVLWTAITLFIFLVCCQIPLFGIMSSDSADPFYWMRVILASNRGTLMELGISPIVTSGLIMQLLAGAK
IIEVGDTPKDRALFNGAQKYDEDDPAEAEKEGNEMEGEELDPLDAYMEEVKEEVKKFNMRSVKGGGGNEKKSGPTVTKVVTVVTTKKAVV
DSDKKKGELMENDQDAMEYSSEEEEVDLQTALTGYQTKQRKLLEPVDHGKIEYEPFRKNFYVEVPELAKMSQEEVNVFRLEMEGITVKGK
GCPKPIKSWVQCGISMKILNSLKKHGYEKPTPIQTQAIPAIMSGRDLIGIAKTGSGKTIAFLLPMFRHIMDQRSLEEGEGPIAVIMTPTR
ELALQITKECKKFSKTLGLRVVCVYGGTGISEQIAELKRGAEIIVCTPGRMIDMLAANSGRVTNLRRVTYVVLDEADRMFDMGFEPQVMR
IVDNVRPDRQTVMFSATFPRAMEALARRILSKPIEVQVGGRSVVCSDVEQQVIVIEEEKKFLKLLELLGHYQESGSVIIFVDKQEHADGL
LKDLMRASYPCMSLHGGIDQYDRDSIINDFKNGTCKLLVATSVAARGLDVKHLILVVNYSCPNHYEDYVHRAGRTGRAGNKGYAYTFITE
DQARYAGDIIKALELSGTAVPPDLEKLWSDFKDQQKAEGKIIKKSSGFSGKGFKFDETEQALANERKKLQKAALGLQDSDDEDAAVDIDE
QIESMFNSKKRVKDMAAPGTSSVPAPTAGNAEKLEIAKRLALRINAQKNLGIESQDVMQQATNAILRGGTILAPTVSAKTIAEQLAEKIN
AKLNYVPLEKQEEERQDGGQNESFKRYEEELEINDFPQTARWKVTSKEALQRISEYSEAAITIRGTYFPPGKEPKEGERKIYLAIESANE

--------------------------------------------------------------
>80127_80127_4_SEC61A1-DDX46_SEC61A1_chr3_127775683_ENST00000464451_DDX46_chr5_134113264_ENST00000452510_length(transcript)=5533nt_BP=615nt
AATCACACCGCCATGCTTTGCCCACAACAGTCTCCTCAACCTGTTCCCTCATTCCTTCTCGCCAGAATCTATCAAGGCTCGGCACAAAGG
TACTCTCCCAGGAGGCCTTCCTGAATTCTTCTGTGAGGCAGACTACTTCCCGAGCTGCCCCGGCCCTTCTCCGGCCAAGTCTCTCCAGAA
ACTCATCCCATTCGTTCTCAGATGGAAGGGGACCCACACCCACGACAAGCCTCCGGGTTTGCTTAATGACTCAGACAGCGAGGGTGCTCG
TCAAATTTCTGGAAGTCATCAAGCCCTTCTGTGTCATCCTGCCGGAAATTCAGAAGCCAGAGAGGAAGATTCAGTTTAAGGAGAAAGTGC
TGTGGACCGCTATCACCCTCTTTATCTTCTTAGTGTGCTGCCAGATTCCCCTGTTTGGGATCATGTCTTCAGATTCAGCTGACCCTTTCT
ATTGGATGAGAGTGATTCTAGCCTCTAACAGAGGCACATTGATGGAGCTAGGGATCTCTCCTATTGTCACGTCTGGCCTTATAATGCAAC
TCTTGGCTGGCGCCAAGATAATTGAAGTTGGTGACACCCCAAAAGACCGAGCTCTCTTCAACGGAGCCCAAAAGTATGACGAAGATGATC
CTGCAGAAGCTGAAAAGGAGGGAAATGAAATGGAGGGTGAGGAGTTAGATCCATTAGATGCTTACATGGAAGAAGTGAAAGAGGAAGTAA
AAAAATTTAACATGAGAAGTGTAAAAGGTGGTGGGGGAAATGAAAAGAAGTCTGGGCCAACGGTCACAAAAGTTGTCACTGTTGTGACAA
CCAAAAAAGCAGTTGTGGATTCTGATAAGAAGAAAGGTGAGCTGATGGAGAATGACCAGGATGCCATGGAGTATTCTTCAGAGGAGGAAG
AAGTTGATCTTCAGACAGCCCTTACAGGGTATCAAACAAAACAGCGAAAGCTTCTAGAACCAGTTGATCATGGAAAAATTGAGTATGAGC
CATTTAGGAAAAACTTCTATGTTGAAGTTCCAGAACTAGCAAAAATGTCTCAAGAAGAGGTAAATGTGTTTCGATTGGAAATGGAGGGCA
TTACAGTTAAAGGAAAAGGTTGCCCCAAACCAATTAAATCCTGGGTCCAGTGTGGAATTTCCATGAAGATCTTAAATTCCCTCAAGAAGC
ATGGCTATGAAAAGCCCACGCCCATCCAAACCCAAGCTATTCCTGCTATAATGTCTGGACGAGATTTGATTGGCATTGCCAAAACAGGAA
GTGGAAAGACCATTGCTTTTCTGTTGCCCATGTTTAGACACATCATGGATCAGAGGTCATTAGAGGAAGGAGAGGGGCCAATAGCTGTCA
TCATGACTCCAACTCGAGAACTGGCTTTACAGATTACTAAAGAGTGTAAGAAGTTTTCCAAGACTTTGGGACTTAGAGTGGTCTGTGTTT
ACGGAGGAACAGGAATCAGTGAGCAGATTGCTGAGCTGAAAAGAGGTGCTGAAATTATTGTTTGCACACCTGGTCGAATGATTGACATGT
TAGCCGCTAACAGTGGTCGGGTCACAAATCTTCGAAGAGTGACATATGTTGTTTTAGATGAAGCAGACAGAATGTTTGACATGGGTTTTG
AACCCCAGGTCATGCGCATCGTGGATAATGTTCGTCCTGATCGACAGACGGTTATGTTTTCAGCTACTTTCCCCAGAGCTATGGAGGCTT
TGGCTCGCAGGATCCTCAGTAAACCTATTGAAGTACAAGTTGGAGGCAGGAGTGTGGTTTGCTCAGATGTGGAGCAACAAGTGATTGTGA
TTGAAGAAGAAAAGAAATTCTTGAAGTTACTTGAGCTTCTAGGCCATTATCAAGAGTCAGGATCTGTCATTATATTTGTGGATAAGCAGG
AACATGCTGATGGTCTTCTTAAGGATTTAATGAGAGCATCTTATCCTTGCATGTCTCTTCATGGAGGCATTGATCAATATGACAGAGATA
GCATCATAAATGACTTTAAGAATGGGACCTGCAAACTTCTTGTGGCTACCTCTGTTGCTGCCCGAGGTCTAGATGTGAAACATCTGATTC
TTGTAGTAAATTATAGCTGCCCCAACCATTATGAGGATTATGTACACAGAGCAGGGCGGACTGGAAGAGCAGGAAACAAGGGTTATGCTT
ATACTTTTATCACAGAGGATCAAGCTCGCTATGCTGGTGACATAATTAAAGCTCTTGAATTGTCAGGGACTGCAGTACCTCCTGATTTAG
AGAAACTGTGGAGTGATTTCAAAGATCAGCAGAAAGCTGAGGGGAAAATAATTAAAAAGAGTAGTGGGTTCTCTGGTAAGGGATTCAAGT
TTGATGAAACAGAACAAGCTTTGGCTAATGAGAGGAAGAAGTTACAAAAAGCAGCTCTTGGTCTACAAGATTCAGATGATGAGGATGCTG
CAGTTGATATTGATGAGCAAATTGAAAGCATGTTTAATTCAAAGAAGAGAGTAAAGGATATGGCTGCTCCTGGAACATCAAGTGTTCCTG
CTCCAACTGCAGGAAATGCTGAGAAATTAGAAATTGCTAAGAGATTGGCTCTTAGAATCAATGCCCAGAAGAATTTGGGCATCGAGTCTC
AGGTAGATGTGATGCAGCAGGCCACCAATGCAATTCTTAGGGGTGGCACCATTCTGGCTCCCACTGTTTCTGCAAAAACCATTGCAGAAC
AACTTGCTGAAAAGATCAATGCCAAGCTCAATTATGTGCCGTTAGAGAAACAAGAAGAAGAGAGACAGGATGGTGGACAGAATGAATCTT
TTAAGAGATATGAAGAAGAATTAGAGATCAATGACTTCCCACAGACTGCTAGGTGGAAAGTTACCTCTAAGGAAGCTCTGCAGAGAATCA
GTGAATACTCTGAAGCCGCAATTACAATCAGAGGAACCTACTTCCCTCCTGGCAAAGAACCCAAGGAAGGCGAGCGGAAGATTTACTTGG
CAATTGAAAGTGCCAATGAACTGGCTGTGCAGAAAGCAAAGGCAGAAATCACCAGGCTCATAAAAGAAGAGCTGATCCGGCTGCAAAATT
CATACCAACCAACAAATAAAGGAAGATACAAAGTCTTATAGACATCCGGAAAAAAGATTTTTACCTGTGCTGGTCTATGATGTATGTGGC
AGTTGCTGTCTGCAGTTTACAATGTATTGTAAATGAAGATTTTTTAAATTCTATCTTGCTGATTTTTTTTAAATATAAGAAACTGGTACT
TGGTAAAGAAATCTGTCCGTAAGTACCCCCACAATCAGTCAAACTATATTTAAAGCCAGCCTGTTTTCAGAGTATGATGTCCTTTAATGT
AAACTCAAATATCAATATTTTAAATGTCCGGATAATATTCTAGAGGTTTAAAAAATGGAAATATTTGAACTTTCTATTGAAGACAATAAA
GTACACAAGTCGTTAAGGGGCTATTCACTTTATCCTGTACTTTCAATGAAATTGTGATCATTTCCTAAGAAAAGGTAAAATTCACTATCA
TATTTTGTGTCCCCACCTTGATGTTACATGACTCTGGAACAATATGAACTGGATTTAAGAATGTTATAATAGAAGTCTTACAAAATGGGT
TGAGAGTTTTTGTTTCAATTTTTATCATCATAAATGGGCAAAAAGTAGTTGGACTAATTTCGGTTTTTATACAAGTAAAGATTTAATAGT
ATAAGGATTTTTTTGCATTTCTTTACACTGAGTGTAAAACTCTACAAAGAGTTATAGTATTTACTACTTTGAGGTTTCCCTCACAACTTC
TGGCTCCATACCTAGCCCCTCTTTTATAATCTTCCTTAAAAGAAAGAGTGTAGCCTATAAATACTAAATATGATACCTTTTCCTTCTAGA
AAGTGTTTATTTATATATCTATACATGTTGTATGTACAAATATCCTACTACTTTTAATCTGATTTTTCTTCAGGATTATTGAGTAGGTTG
TGAATTTTCTTTCTTAAAAATTGTAAAACATAATGGTACCCAAGTTTTAAACTTAGATGTGCTTCATCTTAGTGAAATTTAATTCACAAG
GAATCATAAATTGTGTTTTTGAGGCTGGGCGCAGTGACTCACACCTGTATCCCAGCAATTTGGGAGGCCGAGGTGGGCAGATCACTTGAG
GTCAGGAGTTCAAGACTAGCCTGGTCAACATGGTGAAACCCTGTCTCTACTAAAAATACAAAAATTAGTCGGCATGGTGGTGGGTGGCTG
TAATCCCAGCTACTCAGGAGGCTGAGGCAGAAGAATCTGAGCCAAGATAACACCATTGCACTCCAGCCTGGGCGACAGAGTGAGACTATC
TCAAAAATAAATAAATAAATAAATAAATAGTATTTTTGAGCCTTCAAGATACAGTTCCTGAATATTCTAATTTAAATTGTTATAATTGGA
TTACCTAATATTCTTTTCAAGACTCCTGATGTATTAACTTCATGTTATTGTCACTTTTCAAAAAAGGAATTTTTTTCAGGAGTTAAATAA
AGTCAGTCTTTTATATCCAAGGGTTTCAAACCCACAGATTAAACCAACCACAGATCAAAAATAGAAAAAAAAAAAAAAAGAAAAAAAGAA
TGTAAAATTTTAAAAATACAGTTTAACAGCTGTAAAAGTTTTACTATAACATTTACATTGTGTTAGGTATTTTAAGTAATTTAAAGGTTA
CAGTATACAGGCGGTTAAAGTATACAGGAGGATGTGCATCGGTTATATGCATATAGCAAGCCATTTCATATAAGAGGCTTGAACATCCAT
GGATTTTGGTATAGAGGAGGGGTTTAAGGGGTGTCCTGCAATCAGTCCCCCTCTCATACCAAAGGATGACTGTATATTTCTTAAATGAAG
AGACTTTCATTCTTTAAATATTATTGACTTACAGTTTAAAAATAAATAAATAAAAGCATACTATAGTTGTAAAAACAAATAATTTTAATA
GTATATTCAGTGGCTGAAGTGATAGGGAGTATTAATCATTATTTCTTCAGTATAAAGTTATTCTTCCTGAAAAAGTAAGATATACCTGGG
AAATATTCTTGGATCCTTCACACATCCACTTAATTTCTTGAAGGAAGAAAACAGACAAAAGACATGTAACAACAGAAACAAATAAACCAC
TTACTGTAAAATTTCAGAAATTGTGGGCTCATTCCCTCCCTCTAGTTTATTTATTTGCTCATCTTTATCACCTAATGGTAGTTTGTTTTC
TTTGGTAGAGTATATGGCAGTCCCACATCGATGATAATTGGTGCTCCCTTCATCCAACTGGATCACTTTGAGATTCAGTTTTACATCATT
TTAGCATTTTGTTTGTATATCAGTTGTGATGAGCCACTGATAAAATTTTGTTCTAAAATGAAACATATTACTTTGTTAGTACATTTTTTA
GTGTCACACTGACTTTTAAAATTTGAATGATATATAGACTTTGTTTTTTTAATGCAATATGAATATTTGCTCATGTTTTCTAAATTCCTT

>80127_80127_4_SEC61A1-DDX46_SEC61A1_chr3_127775683_ENST00000464451_DDX46_chr5_134113264_ENST00000452510_length(amino acids)=1027AA_BP=200
MPTTVSSTCSLIPSRQNLSRLGTKVLSQEAFLNSSVRQTTSRAAPALLRPSLSRNSSHSFSDGRGPTPTTSLRVCLMTQTARVLVKFLEV
IKPFCVILPEIQKPERKIQFKEKVLWTAITLFIFLVCCQIPLFGIMSSDSADPFYWMRVILASNRGTLMELGISPIVTSGLIMQLLAGAK
IIEVGDTPKDRALFNGAQKYDEDDPAEAEKEGNEMEGEELDPLDAYMEEVKEEVKKFNMRSVKGGGGNEKKSGPTVTKVVTVVTTKKAVV
DSDKKKGELMENDQDAMEYSSEEEEVDLQTALTGYQTKQRKLLEPVDHGKIEYEPFRKNFYVEVPELAKMSQEEVNVFRLEMEGITVKGK
GCPKPIKSWVQCGISMKILNSLKKHGYEKPTPIQTQAIPAIMSGRDLIGIAKTGSGKTIAFLLPMFRHIMDQRSLEEGEGPIAVIMTPTR
ELALQITKECKKFSKTLGLRVVCVYGGTGISEQIAELKRGAEIIVCTPGRMIDMLAANSGRVTNLRRVTYVVLDEADRMFDMGFEPQVMR
IVDNVRPDRQTVMFSATFPRAMEALARRILSKPIEVQVGGRSVVCSDVEQQVIVIEEEKKFLKLLELLGHYQESGSVIIFVDKQEHADGL
LKDLMRASYPCMSLHGGIDQYDRDSIINDFKNGTCKLLVATSVAARGLDVKHLILVVNYSCPNHYEDYVHRAGRTGRAGNKGYAYTFITE
DQARYAGDIIKALELSGTAVPPDLEKLWSDFKDQQKAEGKIIKKSSGFSGKGFKFDETEQALANERKKLQKAALGLQDSDDEDAAVDIDE
QIESMFNSKKRVKDMAAPGTSSVPAPTAGNAEKLEIAKRLALRINAQKNLGIESQVDVMQQATNAILRGGTILAPTVSAKTIAEQLAEKI
NAKLNYVPLEKQEEERQDGGQNESFKRYEEELEINDFPQTARWKVTSKEALQRISEYSEAAITIRGTYFPPGKEPKEGERKIYLAIESAN

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Fusion Gene PPI Analysis for SEC61A1-DDX46


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for SEC61A1-DDX46


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for SEC61A1-DDX46


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource