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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:SEMA3C-CD36 (FusionGDB2 ID:80278)

Fusion Gene Summary for SEMA3C-CD36

check button Fusion gene summary
Fusion gene informationFusion gene name: SEMA3C-CD36
Fusion gene ID: 80278
HgeneTgene
Gene symbol

SEMA3C

CD36

Gene ID

10512

948

Gene namesemaphorin 3CCD36 molecule
SynonymsSEMAE|SemEBDPLT10|CHDS7|FAT|GP3B|GP4|GPIV|PASIV|SCARB3
Cytomap

7q21.11

7q21.11

Type of geneprotein-codingprotein-coding
Descriptionsemaphorin-3Csema Esema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3Csemaphorin Eplatelet glycoprotein 4CD36 antigen (collagen type I receptor, thrombospondin receptor)CD36 molecule (thrombospondin receptor)GPIIIBPAS IVPAS-4 proteincluster determinant 36fatty acid translocaseglycoprotein IIIbleukocyte differentiation antigen
Modification date2020031320200322
UniProtAcc.

P16671

Ensembl transtripts involved in fusion geneENST00000265361, ENST00000419255, 
ENST00000536800, ENST00000544525, 
ENST00000487621, 		ENST00000435819, 
ENST00000309881, ENST00000394788, 
ENST00000432207, ENST00000433696, 
ENST00000441109, ENST00000447544, 
ENST00000534394, ENST00000538969, 
ENST00000544133, 
Fusion gene scores* DoF score7 X 5 X 5=1755 X 6 X 4=120
# samples 86
** MAII scorelog2(8/175*10)=-1.12928301694497
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(6/120*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SEMA3C [Title/Abstract] AND CD36 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointSEMA3C(80545995)-CD36(80115783), # samples:2
Anticipated loss of major functional domain due to fusion event.SEMA3C-CD36 seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
SEMA3C-CD36 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneCD36

GO:0001954

positive regulation of cell-matrix adhesion

17416590

TgeneCD36

GO:0007263

nitric oxide mediated signal transduction

17416590

TgeneCD36

GO:0019934

cGMP-mediated signaling

17416590

TgeneCD36

GO:0044539

long-chain fatty acid import

17416590|22022213

TgeneCD36

GO:0071726

cellular response to diacyl bacterial lipopeptide

16880211


check buttonFusion gene breakpoints across SEMA3C (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across CD36 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BLCATCGA-GV-A3QF-01ASEMA3Cchr7

80545995

-CD36chr7

80293722

+
ChimerDB4LUSCTCGA-22-5492-01ASEMA3Cchr7

80545995

-CD36chr7

80115783

+


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Fusion Gene ORF analysis for SEMA3C-CD36

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000265361ENST00000435819SEMA3Cchr7

80545995

-CD36chr7

80115783

+
5CDS-5UTRENST00000419255ENST00000435819SEMA3Cchr7

80545995

-CD36chr7

80115783

+
5CDS-5UTRENST00000536800ENST00000435819SEMA3Cchr7

80545995

-CD36chr7

80115783

+
5CDS-5UTRENST00000544525ENST00000435819SEMA3Cchr7

80545995

-CD36chr7

80115783

+
5CDS-intronENST00000265361ENST00000309881SEMA3Cchr7

80545995

-CD36chr7

80115783

+
5CDS-intronENST00000265361ENST00000394788SEMA3Cchr7

80545995

-CD36chr7

80293722

+
5CDS-intronENST00000265361ENST00000394788SEMA3Cchr7

80545995

-CD36chr7

80115783

+
5CDS-intronENST00000265361ENST00000432207SEMA3Cchr7

80545995

-CD36chr7

80293722

+
5CDS-intronENST00000265361ENST00000432207SEMA3Cchr7

80545995

-CD36chr7

80115783

+
5CDS-intronENST00000265361ENST00000433696SEMA3Cchr7

80545995

-CD36chr7

80293722

+
5CDS-intronENST00000265361ENST00000433696SEMA3Cchr7

80545995

-CD36chr7

80115783

+
5CDS-intronENST00000265361ENST00000441109SEMA3Cchr7

80545995

-CD36chr7

80293722

+
5CDS-intronENST00000265361ENST00000441109SEMA3Cchr7

80545995

-CD36chr7

80115783

+
5CDS-intronENST00000265361ENST00000447544SEMA3Cchr7

80545995

-CD36chr7

80293722

+
5CDS-intronENST00000265361ENST00000447544SEMA3Cchr7

80545995

-CD36chr7

80115783

+
5CDS-intronENST00000265361ENST00000534394SEMA3Cchr7

80545995

-CD36chr7

80115783

+
5CDS-intronENST00000265361ENST00000538969SEMA3Cchr7

80545995

-CD36chr7

80293722

+
5CDS-intronENST00000265361ENST00000538969SEMA3Cchr7

80545995

-CD36chr7

80115783

+
5CDS-intronENST00000265361ENST00000544133SEMA3Cchr7

80545995

-CD36chr7

80293722

+
5CDS-intronENST00000265361ENST00000544133SEMA3Cchr7

80545995

-CD36chr7

80115783

+
5CDS-intronENST00000419255ENST00000309881SEMA3Cchr7

80545995

-CD36chr7

80115783

+
5CDS-intronENST00000419255ENST00000394788SEMA3Cchr7

80545995

-CD36chr7

80293722

+
5CDS-intronENST00000419255ENST00000394788SEMA3Cchr7

80545995

-CD36chr7

80115783

+
5CDS-intronENST00000419255ENST00000432207SEMA3Cchr7

80545995

-CD36chr7

80293722

+
5CDS-intronENST00000419255ENST00000432207SEMA3Cchr7

80545995

-CD36chr7

80115783

+
5CDS-intronENST00000419255ENST00000433696SEMA3Cchr7

80545995

-CD36chr7

80293722

+
5CDS-intronENST00000419255ENST00000433696SEMA3Cchr7

80545995

-CD36chr7

80115783

+
5CDS-intronENST00000419255ENST00000441109SEMA3Cchr7

80545995

-CD36chr7

80293722

+
5CDS-intronENST00000419255ENST00000441109SEMA3Cchr7

80545995

-CD36chr7

80115783

+
5CDS-intronENST00000419255ENST00000447544SEMA3Cchr7

80545995

-CD36chr7

80293722

+
5CDS-intronENST00000419255ENST00000447544SEMA3Cchr7

80545995

-CD36chr7

80115783

+
5CDS-intronENST00000419255ENST00000534394SEMA3Cchr7

80545995

-CD36chr7

80115783

+
5CDS-intronENST00000419255ENST00000538969SEMA3Cchr7

80545995

-CD36chr7

80293722

+
5CDS-intronENST00000419255ENST00000538969SEMA3Cchr7

80545995

-CD36chr7

80115783

+
5CDS-intronENST00000419255ENST00000544133SEMA3Cchr7

80545995

-CD36chr7

80293722

+
5CDS-intronENST00000419255ENST00000544133SEMA3Cchr7

80545995

-CD36chr7

80115783

+
5CDS-intronENST00000536800ENST00000309881SEMA3Cchr7

80545995

-CD36chr7

80115783

+
5CDS-intronENST00000536800ENST00000394788SEMA3Cchr7

80545995

-CD36chr7

80293722

+
5CDS-intronENST00000536800ENST00000394788SEMA3Cchr7

80545995

-CD36chr7

80115783

+
5CDS-intronENST00000536800ENST00000432207SEMA3Cchr7

80545995

-CD36chr7

80293722

+
5CDS-intronENST00000536800ENST00000432207SEMA3Cchr7

80545995

-CD36chr7

80115783

+
5CDS-intronENST00000536800ENST00000433696SEMA3Cchr7

80545995

-CD36chr7

80293722

+
5CDS-intronENST00000536800ENST00000433696SEMA3Cchr7

80545995

-CD36chr7

80115783

+
5CDS-intronENST00000536800ENST00000441109SEMA3Cchr7

80545995

-CD36chr7

80293722

+
5CDS-intronENST00000536800ENST00000441109SEMA3Cchr7

80545995

-CD36chr7

80115783

+
5CDS-intronENST00000536800ENST00000447544SEMA3Cchr7

80545995

-CD36chr7

80293722

+
5CDS-intronENST00000536800ENST00000447544SEMA3Cchr7

80545995

-CD36chr7

80115783

+
5CDS-intronENST00000536800ENST00000534394SEMA3Cchr7

80545995

-CD36chr7

80115783

+
5CDS-intronENST00000536800ENST00000538969SEMA3Cchr7

80545995

-CD36chr7

80293722

+
5CDS-intronENST00000536800ENST00000538969SEMA3Cchr7

80545995

-CD36chr7

80115783

+
5CDS-intronENST00000536800ENST00000544133SEMA3Cchr7

80545995

-CD36chr7

80293722

+
5CDS-intronENST00000536800ENST00000544133SEMA3Cchr7

80545995

-CD36chr7

80115783

+
5CDS-intronENST00000544525ENST00000309881SEMA3Cchr7

80545995

-CD36chr7

80115783

+
5CDS-intronENST00000544525ENST00000394788SEMA3Cchr7

80545995

-CD36chr7

80293722

+
5CDS-intronENST00000544525ENST00000394788SEMA3Cchr7

80545995

-CD36chr7

80115783

+
5CDS-intronENST00000544525ENST00000432207SEMA3Cchr7

80545995

-CD36chr7

80293722

+
5CDS-intronENST00000544525ENST00000432207SEMA3Cchr7

80545995

-CD36chr7

80115783

+
5CDS-intronENST00000544525ENST00000433696SEMA3Cchr7

80545995

-CD36chr7

80293722

+
5CDS-intronENST00000544525ENST00000433696SEMA3Cchr7

80545995

-CD36chr7

80115783

+
5CDS-intronENST00000544525ENST00000441109SEMA3Cchr7

80545995

-CD36chr7

80293722

+
5CDS-intronENST00000544525ENST00000441109SEMA3Cchr7

80545995

-CD36chr7

80115783

+
5CDS-intronENST00000544525ENST00000447544SEMA3Cchr7

80545995

-CD36chr7

80293722

+
5CDS-intronENST00000544525ENST00000447544SEMA3Cchr7

80545995

-CD36chr7

80115783

+
5CDS-intronENST00000544525ENST00000534394SEMA3Cchr7

80545995

-CD36chr7

80115783

+
5CDS-intronENST00000544525ENST00000538969SEMA3Cchr7

80545995

-CD36chr7

80293722

+
5CDS-intronENST00000544525ENST00000538969SEMA3Cchr7

80545995

-CD36chr7

80115783

+
5CDS-intronENST00000544525ENST00000544133SEMA3Cchr7

80545995

-CD36chr7

80293722

+
5CDS-intronENST00000544525ENST00000544133SEMA3Cchr7

80545995

-CD36chr7

80115783

+
5UTR-3CDSENST00000487621ENST00000309881SEMA3Cchr7

80545995

-CD36chr7

80293722

+
5UTR-3CDSENST00000487621ENST00000435819SEMA3Cchr7

80545995

-CD36chr7

80293722

+
5UTR-3CDSENST00000487621ENST00000534394SEMA3Cchr7

80545995

-CD36chr7

80293722

+
5UTR-5UTRENST00000487621ENST00000435819SEMA3Cchr7

80545995

-CD36chr7

80115783

+
5UTR-intronENST00000487621ENST00000309881SEMA3Cchr7

80545995

-CD36chr7

80115783

+
5UTR-intronENST00000487621ENST00000394788SEMA3Cchr7

80545995

-CD36chr7

80293722

+
5UTR-intronENST00000487621ENST00000394788SEMA3Cchr7

80545995

-CD36chr7

80115783

+
5UTR-intronENST00000487621ENST00000432207SEMA3Cchr7

80545995

-CD36chr7

80293722

+
5UTR-intronENST00000487621ENST00000432207SEMA3Cchr7

80545995

-CD36chr7

80115783

+
5UTR-intronENST00000487621ENST00000433696SEMA3Cchr7

80545995

-CD36chr7

80293722

+
5UTR-intronENST00000487621ENST00000433696SEMA3Cchr7

80545995

-CD36chr7

80115783

+
5UTR-intronENST00000487621ENST00000441109SEMA3Cchr7

80545995

-CD36chr7

80293722

+
5UTR-intronENST00000487621ENST00000441109SEMA3Cchr7

80545995

-CD36chr7

80115783

+
5UTR-intronENST00000487621ENST00000447544SEMA3Cchr7

80545995

-CD36chr7

80293722

+
5UTR-intronENST00000487621ENST00000447544SEMA3Cchr7

80545995

-CD36chr7

80115783

+
5UTR-intronENST00000487621ENST00000534394SEMA3Cchr7

80545995

-CD36chr7

80115783

+
5UTR-intronENST00000487621ENST00000538969SEMA3Cchr7

80545995

-CD36chr7

80293722

+
5UTR-intronENST00000487621ENST00000538969SEMA3Cchr7

80545995

-CD36chr7

80115783

+
5UTR-intronENST00000487621ENST00000544133SEMA3Cchr7

80545995

-CD36chr7

80293722

+
5UTR-intronENST00000487621ENST00000544133SEMA3Cchr7

80545995

-CD36chr7

80115783

+
Frame-shiftENST00000419255ENST00000309881SEMA3Cchr7

80545995

-CD36chr7

80293722

+
Frame-shiftENST00000419255ENST00000435819SEMA3Cchr7

80545995

-CD36chr7

80293722

+
Frame-shiftENST00000419255ENST00000534394SEMA3Cchr7

80545995

-CD36chr7

80293722

+
Frame-shiftENST00000536800ENST00000309881SEMA3Cchr7

80545995

-CD36chr7

80293722

+
Frame-shiftENST00000536800ENST00000435819SEMA3Cchr7

80545995

-CD36chr7

80293722

+
Frame-shiftENST00000536800ENST00000534394SEMA3Cchr7

80545995

-CD36chr7

80293722

+
Frame-shiftENST00000544525ENST00000309881SEMA3Cchr7

80545995

-CD36chr7

80293722

+
Frame-shiftENST00000544525ENST00000435819SEMA3Cchr7

80545995

-CD36chr7

80293722

+
Frame-shiftENST00000544525ENST00000534394SEMA3Cchr7

80545995

-CD36chr7

80293722

+
In-frameENST00000265361ENST00000309881SEMA3Cchr7

80545995

-CD36chr7

80293722

+
In-frameENST00000265361ENST00000435819SEMA3Cchr7

80545995

-CD36chr7

80293722

+
In-frameENST00000265361ENST00000534394SEMA3Cchr7

80545995

-CD36chr7

80293722

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000265361SEMA3Cchr780545995-ENST00000435819CD36chr780293722+17376656591474271
ENST00000265361SEMA3Cchr780545995-ENST00000309881CD36chr780293722+17376656591474271
ENST00000265361SEMA3Cchr780545995-ENST00000534394CD36chr780293722+17446656591474271

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000265361ENST00000435819SEMA3Cchr780545995-CD36chr780293722+0.0009691410.9990308
ENST00000265361ENST00000309881SEMA3Cchr780545995-CD36chr780293722+0.0009691410.9990308
ENST00000265361ENST00000534394SEMA3Cchr780545995-CD36chr780293722+0.0009557870.99904424

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Fusion Genomic Features for SEMA3C-CD36


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
SEMA3Cchr780545994-CD36chr780115782+0.0803912650.9196087
SEMA3Cchr780545994-CD36chr780293721+0.038754560.9612454
SEMA3Cchr780545994-CD36chr780115782+0.0803912650.9196087
SEMA3Cchr780545994-CD36chr780293721+0.038754560.9612454

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for SEMA3C-CD36


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr7:80545995/chr7:80115783)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.CD36

P16671

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Multifunctional glycoprotein that acts as receptor for a broad range of ligands. Ligands can be of proteinaceous nature like thrombospondin, fibronectin, collagen or amyloid-beta as well as of lipidic nature such as oxidized low-density lipoprotein (oxLDL), anionic phospholipids, long-chain fatty acids and bacterial diacylated lipopeptides. They are generally multivalent and can therefore engage multiple receptors simultaneously, the resulting formation of CD36 clusters initiates signal transduction and internalization of receptor-ligand complexes. The dependency on coreceptor signaling is strongly ligand specific. Cellular responses to these ligands are involved in angiogenesis, inflammatory response, fatty acid metabolism, taste and dietary fat processing in the intestine (Probable). Binds long-chain fatty acids and facilitates their transport into cells, thus participating in muscle lipid utilization, adipose energy storage, and gut fat absorption (By similarity) (PubMed:18353783, PubMed:21610069). In the small intestine, plays a role in proximal absorption of dietary fatty acid and cholesterol for optimal chylomicron formation, possibly through the activation of MAPK1/3 (ERK1/2) signaling pathway (By similarity) (PubMed:18753675). Involved in oral fat perception and preferences (PubMed:22240721, PubMed:25822988). Detection into the tongue of long-chain fatty acids leads to a rapid and sustained rise in flux and protein content of pancreatobiliary secretions (By similarity). In taste receptor cells, mediates the induction of an increase in intracellular calcium levels by long-chain fatty acids, leading to the activation of the gustatory neurons in the nucleus of the solitary tract (By similarity). Important factor in both ventromedial hypothalamus neuronal sensing of long-chain fatty acid and the regulation of energy and glucose homeostasis (By similarity). Receptor for thombospondins, THBS1 and THBS2, mediating their antiangiogenic effects (By similarity). As a coreceptor for TLR4:TLR6 heterodimer, promotes inflammation in monocytes/macrophages. Upon ligand binding, such as oxLDL or amyloid-beta 42, interacts with the heterodimer TLR4:TLR6, the complex is internalized and triggers inflammatory response, leading to NF-kappa-B-dependent production of CXCL1, CXCL2 and CCL9 cytokines, via MYD88 signaling pathway, and CCL5 cytokine, via TICAM1 signaling pathway, as well as IL1B secretion, through the priming and activation of the NLRP3 inflammasome (By similarity) (PubMed:20037584). Selective and nonredundant sensor of microbial diacylated lipopeptide that signal via TLR2:TLR6 heterodimer, this cluster triggers signaling from the cell surface, leading to the NF-kappa-B-dependent production of TNF, via MYD88 signaling pathway and subsequently is targeted to the Golgi in a lipid-raft dependent pathway (By similarity) (PubMed:16880211). {ECO:0000250|UniProtKB:Q07969, ECO:0000250|UniProtKB:Q08857, ECO:0000269|PubMed:16880211, ECO:0000269|PubMed:18353783, ECO:0000269|PubMed:18753675, ECO:0000269|PubMed:20037584, ECO:0000269|PubMed:21395585, ECO:0000269|PubMed:21610069, ECO:0000269|PubMed:22240721, ECO:0000269|PubMed:25822988, ECO:0000305|PubMed:19471024}.; FUNCTION: (Microbial infection) Directly mediates cytoadherence of Plasmodium falciparum parasitized erythrocytes and the internalization of particles independently of TLR signaling. {ECO:0000269|PubMed:10890433, ECO:0000269|PubMed:12506336, ECO:0000269|PubMed:19864601}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneCD36chr7:80545995chr7:80293722ENST00000309881514440_461203473.0TransmembraneHelical
TgeneCD36chr7:80545995chr7:80293722ENST00000394788514440_461203473.0TransmembraneHelical
TgeneCD36chr7:80545995chr7:80293722ENST00000432207413440_461203473.0TransmembraneHelical
TgeneCD36chr7:80545995chr7:80293722ENST00000435819817440_461203473.0TransmembraneHelical
TgeneCD36chr7:80545995chr7:80293722ENST00000447544515440_461203657.6666666666666TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSEMA3Cchr7:80545995chr7:80293722ENST00000265361-218724_74534752.0Compositional biasNote=Arg/Lys-rich (basic)
HgeneSEMA3Cchr7:80545995chr7:80293722ENST00000419255-218724_74534752.0Compositional biasNote=Arg/Lys-rich (basic)
HgeneSEMA3Cchr7:80545995chr7:80293722ENST00000265361-21828_51134752.0DomainSema
HgeneSEMA3Cchr7:80545995chr7:80293722ENST00000265361-218571_65534752.0DomainNote=Ig-like C2-type
HgeneSEMA3Cchr7:80545995chr7:80293722ENST00000419255-21828_51134752.0DomainSema
HgeneSEMA3Cchr7:80545995chr7:80293722ENST00000419255-218571_65534752.0DomainNote=Ig-like C2-type
TgeneCD36chr7:80545995chr7:80293722ENST000003098815142_7203473.0Topological domainCytoplasmic
TgeneCD36chr7:80545995chr7:80293722ENST0000030988151430_439203473.0Topological domainExtracellular
TgeneCD36chr7:80545995chr7:80293722ENST000003947885142_7203473.0Topological domainCytoplasmic
TgeneCD36chr7:80545995chr7:80293722ENST0000039478851430_439203473.0Topological domainExtracellular
TgeneCD36chr7:80545995chr7:80293722ENST000004322074132_7203473.0Topological domainCytoplasmic
TgeneCD36chr7:80545995chr7:80293722ENST0000043220741330_439203473.0Topological domainExtracellular
TgeneCD36chr7:80545995chr7:80293722ENST000004358198172_7203473.0Topological domainCytoplasmic
TgeneCD36chr7:80545995chr7:80293722ENST0000043581981730_439203473.0Topological domainExtracellular
TgeneCD36chr7:80545995chr7:80293722ENST000004475445152_7203657.6666666666666Topological domainCytoplasmic
TgeneCD36chr7:80545995chr7:80293722ENST0000044754451530_439203657.6666666666666Topological domainExtracellular
TgeneCD36chr7:80545995chr7:80293722ENST000003098815148_29203473.0TransmembraneHelical
TgeneCD36chr7:80545995chr7:80293722ENST000003947885148_29203473.0TransmembraneHelical
TgeneCD36chr7:80545995chr7:80293722ENST000004322074138_29203473.0TransmembraneHelical
TgeneCD36chr7:80545995chr7:80293722ENST000004358198178_29203473.0TransmembraneHelical
TgeneCD36chr7:80545995chr7:80293722ENST000004475445158_29203657.6666666666666TransmembraneHelical


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Fusion Gene Sequence for SEMA3C-CD36


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>80278_80278_1_SEMA3C-CD36_SEMA3C_chr7_80545995_ENST00000265361_CD36_chr7_80293722_ENST00000309881_length(transcript)=1737nt_BP=665nt
GGACTGCGAAAGGAGCAGGGTTGCGGAGCTAGGGCTCCAGCCTGCGGCCGCGCATTCTTGCGTCTGGCCAGCCGCGAGCTCTAAGGGTCG
GCCCCGCCCGGTCCGCCCCCGCGGCTCCCTGCCAGGCTCTCGCGGGCGCGCTCGGGGTGGGGCCTCGCGGCTGGCGGAGATGCGGCCGGG
GCTGCGCGGTGGTGATGCGAGCCTGCAGGGCGGCGCGCCGGGGCAGCCGGAGCCGCGCGCCGCGGCGCTGTAATCGGACACCAAGAGCGC
TCGCCCCCGGCCTCCGGCCACTTTCCATTCACTCCGAGGTGCTTGATTGAGCGACGCGGAGAAGAGCTCCGGGTGCCGCGGCACTGCAGC
GCTGAGATTCCTTTACAAAGAAACTCAGAGGACCGGGAAGAAAGAATTTCACCTTTGCGACGTGCTAGAAAATAAGGTCGTCTGGGAAAA
GGACTGGAGACACAAGCGCATCCAACCCCGGTAGCAAACTGATGACTTTTCCGTGCTGATTTCTTTCAACCTCGGTATTTTCCCTTGGAT
ATTAACTTGCATATCTGAAGAAATGGCATTCCGGACAATTTGCGTGTTGGTTGGAGTATTTATTTGTTCTATCTGTGTGAAAGGATCTTC
CCAGCCCCAAGCAAGAGTTTATTTAACATTTGATGTACAACAATACTGCAGATGGAGTTTATAAAGTTTTCAATGGAAAAGATAACATAA
GTAAAGTTGCCATAATCGACACATATAAAGGTAAAAGGAATCTGTCCTATTGGGAAAGTCACTGCGACATGATTAATGGTACAGATGCAG
CCTCATTTCCACCTTTTGTTGAGAAAAGCCAGGTATTGCAGTTCTTTTCTTCTGATATTTGCAGGTCAATCTATGCTGTATTTGAATCCG
ACGTTAATCTGAAAGGAATCCCTGTGTATAGATTTGTTCTTCCATCCAAGGCCTTTGCCTCTCCAGTTGAAAACCCAGACAACTATTGTT
TCTGCACAGAAAAAATTATCTCAAAAAATTGTACATCATATGGTGTGCTAGACATCAGCAAATGCAAAGAAGGGAGACCTGTGTACATTT
CACTTCCTCATTTTCTGTATGCAAGTCCTGATGTTTCAGAACCTATTGATGGATTAAACCCAAATGAAGAAGAACATAGGACATACTTGG
ATATTGAACCTATAACTGGATTCACTTTACAATTTGCAAAACGGCTGCAGGTCAACCTATTGGTCAAGCCATCAGAAAAAATTCAAGTAT
TAAAGAATCTGAAGAGGAACTATATTGTGCCTATTCTTTGGCTTAATGAGACTGGGACCATTGGTGATGAGAAGGCAAACATGTTCAGAA
GTCAAGTAACTGGAAAAATAAACCTCCTTGGCCTGATAGAAATGATCTTACTCAGTGTTGGTGTGGTGATGTTTGTTGCTTTTATGATTT
CATATTGTGCATGCAGATCGAAAACAATAAAATAAGTAAGTATGTACCAAAAAATATTGCTTCAATAATATTAGCTTATATATTACTTGT
TTTCACTTTATCAAAGAGAAGTTACATATTAGGCCATATATATTTCTAGACATGTCTAGCCACTGATCATTTTTAAATATAGGTAAATAA
ACCTATAAATATTATCACGCAGATCACTAAAGTATATCTTTAATTCTGGGAGAAATGAGATAAAAGATGTACTTGTGACCATTGTAACAA

>80278_80278_1_SEMA3C-CD36_SEMA3C_chr7_80545995_ENST00000265361_CD36_chr7_80293722_ENST00000309881_length(amino acids)=271AA_BP=2
MMYNNTADGVYKVFNGKDNISKVAIIDTYKGKRNLSYWESHCDMINGTDAASFPPFVEKSQVLQFFSSDICRSIYAVFESDVNLKGIPVY
RFVLPSKAFASPVENPDNYCFCTEKIISKNCTSYGVLDISKCKEGRPVYISLPHFLYASPDVSEPIDGLNPNEEEHRTYLDIEPITGFTL
QFAKRLQVNLLVKPSEKIQVLKNLKRNYIVPILWLNETGTIGDEKANMFRSQVTGKINLLGLIEMILLSVGVVMFVAFMISYCACRSKTI

--------------------------------------------------------------
>80278_80278_2_SEMA3C-CD36_SEMA3C_chr7_80545995_ENST00000265361_CD36_chr7_80293722_ENST00000435819_length(transcript)=1737nt_BP=665nt
GGACTGCGAAAGGAGCAGGGTTGCGGAGCTAGGGCTCCAGCCTGCGGCCGCGCATTCTTGCGTCTGGCCAGCCGCGAGCTCTAAGGGTCG
GCCCCGCCCGGTCCGCCCCCGCGGCTCCCTGCCAGGCTCTCGCGGGCGCGCTCGGGGTGGGGCCTCGCGGCTGGCGGAGATGCGGCCGGG
GCTGCGCGGTGGTGATGCGAGCCTGCAGGGCGGCGCGCCGGGGCAGCCGGAGCCGCGCGCCGCGGCGCTGTAATCGGACACCAAGAGCGC
TCGCCCCCGGCCTCCGGCCACTTTCCATTCACTCCGAGGTGCTTGATTGAGCGACGCGGAGAAGAGCTCCGGGTGCCGCGGCACTGCAGC
GCTGAGATTCCTTTACAAAGAAACTCAGAGGACCGGGAAGAAAGAATTTCACCTTTGCGACGTGCTAGAAAATAAGGTCGTCTGGGAAAA
GGACTGGAGACACAAGCGCATCCAACCCCGGTAGCAAACTGATGACTTTTCCGTGCTGATTTCTTTCAACCTCGGTATTTTCCCTTGGAT
ATTAACTTGCATATCTGAAGAAATGGCATTCCGGACAATTTGCGTGTTGGTTGGAGTATTTATTTGTTCTATCTGTGTGAAAGGATCTTC
CCAGCCCCAAGCAAGAGTTTATTTAACATTTGATGTACAACAATACTGCAGATGGAGTTTATAAAGTTTTCAATGGAAAAGATAACATAA
GTAAAGTTGCCATAATCGACACATATAAAGGTAAAAGGAATCTGTCCTATTGGGAAAGTCACTGCGACATGATTAATGGTACAGATGCAG
CCTCATTTCCACCTTTTGTTGAGAAAAGCCAGGTATTGCAGTTCTTTTCTTCTGATATTTGCAGGTCAATCTATGCTGTATTTGAATCCG
ACGTTAATCTGAAAGGAATCCCTGTGTATAGATTTGTTCTTCCATCCAAGGCCTTTGCCTCTCCAGTTGAAAACCCAGACAACTATTGTT
TCTGCACAGAAAAAATTATCTCAAAAAATTGTACATCATATGGTGTGCTAGACATCAGCAAATGCAAAGAAGGGAGACCTGTGTACATTT
CACTTCCTCATTTTCTGTATGCAAGTCCTGATGTTTCAGAACCTATTGATGGATTAAACCCAAATGAAGAAGAACATAGGACATACTTGG
ATATTGAACCTATAACTGGATTCACTTTACAATTTGCAAAACGGCTGCAGGTCAACCTATTGGTCAAGCCATCAGAAAAAATTCAAGTAT
TAAAGAATCTGAAGAGGAACTATATTGTGCCTATTCTTTGGCTTAATGAGACTGGGACCATTGGTGATGAGAAGGCAAACATGTTCAGAA
GTCAAGTAACTGGAAAAATAAACCTCCTTGGCCTGATAGAAATGATCTTACTCAGTGTTGGTGTGGTGATGTTTGTTGCTTTTATGATTT
CATATTGTGCATGCAGATCGAAAACAATAAAATAAGTAAGTATGTACCAAAAAATATTGCTTCAATAATATTAGCTTATATATTACTTGT
TTTCACTTTATCAAAGAGAAGTTACATATTAGGCCATATATATTTCTAGACATGTCTAGCCACTGATCATTTTTAAATATAGGTAAATAA
ACCTATAAATATTATCACGCAGATCACTAAAGTATATCTTTAATTCTGGGAGAAATGAGATAAAAGATGTACTTGTGACCATTGTAACAA

>80278_80278_2_SEMA3C-CD36_SEMA3C_chr7_80545995_ENST00000265361_CD36_chr7_80293722_ENST00000435819_length(amino acids)=271AA_BP=2
MMYNNTADGVYKVFNGKDNISKVAIIDTYKGKRNLSYWESHCDMINGTDAASFPPFVEKSQVLQFFSSDICRSIYAVFESDVNLKGIPVY
RFVLPSKAFASPVENPDNYCFCTEKIISKNCTSYGVLDISKCKEGRPVYISLPHFLYASPDVSEPIDGLNPNEEEHRTYLDIEPITGFTL
QFAKRLQVNLLVKPSEKIQVLKNLKRNYIVPILWLNETGTIGDEKANMFRSQVTGKINLLGLIEMILLSVGVVMFVAFMISYCACRSKTI

--------------------------------------------------------------
>80278_80278_3_SEMA3C-CD36_SEMA3C_chr7_80545995_ENST00000265361_CD36_chr7_80293722_ENST00000534394_length(transcript)=1744nt_BP=665nt
GGACTGCGAAAGGAGCAGGGTTGCGGAGCTAGGGCTCCAGCCTGCGGCCGCGCATTCTTGCGTCTGGCCAGCCGCGAGCTCTAAGGGTCG
GCCCCGCCCGGTCCGCCCCCGCGGCTCCCTGCCAGGCTCTCGCGGGCGCGCTCGGGGTGGGGCCTCGCGGCTGGCGGAGATGCGGCCGGG
GCTGCGCGGTGGTGATGCGAGCCTGCAGGGCGGCGCGCCGGGGCAGCCGGAGCCGCGCGCCGCGGCGCTGTAATCGGACACCAAGAGCGC
TCGCCCCCGGCCTCCGGCCACTTTCCATTCACTCCGAGGTGCTTGATTGAGCGACGCGGAGAAGAGCTCCGGGTGCCGCGGCACTGCAGC
GCTGAGATTCCTTTACAAAGAAACTCAGAGGACCGGGAAGAAAGAATTTCACCTTTGCGACGTGCTAGAAAATAAGGTCGTCTGGGAAAA
GGACTGGAGACACAAGCGCATCCAACCCCGGTAGCAAACTGATGACTTTTCCGTGCTGATTTCTTTCAACCTCGGTATTTTCCCTTGGAT
ATTAACTTGCATATCTGAAGAAATGGCATTCCGGACAATTTGCGTGTTGGTTGGAGTATTTATTTGTTCTATCTGTGTGAAAGGATCTTC
CCAGCCCCAAGCAAGAGTTTATTTAACATTTGATGTACAACAATACTGCAGATGGAGTTTATAAAGTTTTCAATGGAAAAGATAACATAA
GTAAAGTTGCCATAATCGACACATATAAAGGTAAAAGGAATCTGTCCTATTGGGAAAGTCACTGCGACATGATTAATGGTACAGATGCAG
CCTCATTTCCACCTTTTGTTGAGAAAAGCCAGGTATTGCAGTTCTTTTCTTCTGATATTTGCAGGTCAATCTATGCTGTATTTGAATCCG
ACGTTAATCTGAAAGGAATCCCTGTGTATAGATTTGTTCTTCCATCCAAGGCCTTTGCCTCTCCAGTTGAAAACCCAGACAACTATTGTT
TCTGCACAGAAAAAATTATCTCAAAAAATTGTACATCATATGGTGTGCTAGACATCAGCAAATGCAAAGAAGGGAGACCTGTGTACATTT
CACTTCCTCATTTTCTGTATGCAAGTCCTGATGTTTCAGAACCTATTGATGGATTAAACCCAAATGAAGAAGAACATAGGACATACTTGG
ATATTGAACCTATAACTGGATTCACTTTACAATTTGCAAAACGGCTGCAGGTCAACCTATTGGTCAAGCCATCAGAAAAAATTCAAGTAT
TAAAGAATCTGAAGAGGAACTATATTGTGCCTATTCTTTGGCTTAATGAGACTGGGACCATTGGTGATGAGAAGGCAAACATGTTCAGAA
GTCAAGTAACTGGAAAAATAAACCTCCTTGGCCTGATAGAAATGATCTTACTCAGTGTTGGTGTGGTGATGTTTGTTGCTTTTATGATTT
CATATTGTGCATGCAGATCGAAAACAATAAAATAAGTAAGTATGTACCAAAAAATATTGCTTCAATAATATTAGCTTATATATTACTTGT
TTTCACTTTATCAAAGAGAAGTTACATATTAGGCCATATATATTTCTAGACATGTCTAGCCACTGATCATTTTTAAATATAGGTAAATAA
ACCTATAAATATTATCACGCAGATCACTAAAGTATATCTTTAATTCTGGGAGAAATGAGATAAAAGATGTACTTGTGACCATTGTAACAA

>80278_80278_3_SEMA3C-CD36_SEMA3C_chr7_80545995_ENST00000265361_CD36_chr7_80293722_ENST00000534394_length(amino acids)=271AA_BP=2
MMYNNTADGVYKVFNGKDNISKVAIIDTYKGKRNLSYWESHCDMINGTDAASFPPFVEKSQVLQFFSSDICRSIYAVFESDVNLKGIPVY
RFVLPSKAFASPVENPDNYCFCTEKIISKNCTSYGVLDISKCKEGRPVYISLPHFLYASPDVSEPIDGLNPNEEEHRTYLDIEPITGFTL
QFAKRLQVNLLVKPSEKIQVLKNLKRNYIVPILWLNETGTIGDEKANMFRSQVTGKINLLGLIEMILLSVGVVMFVAFMISYCACRSKTI

--------------------------------------------------------------

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Fusion Gene PPI Analysis for SEMA3C-CD36


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
TgeneCD36chr7:80545995chr7:80293722ENST00000309881514460_472203.0473.0PTK2%2C PXN and LYN
TgeneCD36chr7:80545995chr7:80293722ENST00000394788514460_472203.0473.0PTK2%2C PXN and LYN
TgeneCD36chr7:80545995chr7:80293722ENST00000432207413460_472203.0473.0PTK2%2C PXN and LYN
TgeneCD36chr7:80545995chr7:80293722ENST00000435819817460_472203.0473.0PTK2%2C PXN and LYN
TgeneCD36chr7:80545995chr7:80293722ENST00000447544515460_472203.0657.6666666666666PTK2%2C PXN and LYN


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for SEMA3C-CD36


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for SEMA3C-CD36


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource