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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:SEMA3C-CNTNAP2 (FusionGDB2 ID:80279)

Fusion Gene Summary for SEMA3C-CNTNAP2

check button Fusion gene summary
Fusion gene informationFusion gene name: SEMA3C-CNTNAP2
Fusion gene ID: 80279
HgeneTgene
Gene symbol

SEMA3C

CNTNAP2

Gene ID

10512

26047

Gene namesemaphorin 3Ccontactin associated protein 2
SynonymsSEMAE|SemEAUTS15|CASPR2|CDFE|NRXN4|PTHSL1
Cytomap

7q21.11

7q35-q36.1

Type of geneprotein-codingprotein-coding
Descriptionsemaphorin-3Csema Esema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3Csemaphorin Econtactin-associated protein-like 2cell recognition molecule Caspr2contactin associated protein like 2homolog of Drosophila neurexin IV
Modification date2020031320200313
UniProtAcc.

Q9UHC6

Ensembl transtripts involved in fusion geneENST00000265361, ENST00000419255, 
ENST00000536800, ENST00000544525, 
ENST00000487621, 		ENST00000463592, 
ENST00000361727, ENST00000538075, 
Fusion gene scores* DoF score7 X 5 X 5=17530 X 34 X 9=9180
# samples 836
** MAII scorelog2(8/175*10)=-1.12928301694497
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(36/9180*10)=-4.6724253419715
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SEMA3C [Title/Abstract] AND CNTNAP2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointSEMA3C(80545995)-CNTNAP2(148112509), # samples:3
Anticipated loss of major functional domain due to fusion event.SEMA3C-CNTNAP2 seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF.
SEMA3C-CNTNAP2 seems lost the major protein functional domain in Tgene partner, which is a tumor suppressor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across SEMA3C (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across CNTNAP2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-E2-A1LL-01ASEMA3Cchr7

80545995

-CNTNAP2chr7

148112509

+


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Fusion Gene ORF analysis for SEMA3C-CNTNAP2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000265361ENST00000463592SEMA3Cchr7

80545995

-CNTNAP2chr7

148112509

+
5CDS-3UTRENST00000419255ENST00000463592SEMA3Cchr7

80545995

-CNTNAP2chr7

148112509

+
5CDS-3UTRENST00000536800ENST00000463592SEMA3Cchr7

80545995

-CNTNAP2chr7

148112509

+
5CDS-3UTRENST00000544525ENST00000463592SEMA3Cchr7

80545995

-CNTNAP2chr7

148112509

+
5UTR-3CDSENST00000487621ENST00000361727SEMA3Cchr7

80545995

-CNTNAP2chr7

148112509

+
5UTR-3CDSENST00000487621ENST00000538075SEMA3Cchr7

80545995

-CNTNAP2chr7

148112509

+
5UTR-3UTRENST00000487621ENST00000463592SEMA3Cchr7

80545995

-CNTNAP2chr7

148112509

+
Frame-shiftENST00000419255ENST00000361727SEMA3Cchr7

80545995

-CNTNAP2chr7

148112509

+
Frame-shiftENST00000419255ENST00000538075SEMA3Cchr7

80545995

-CNTNAP2chr7

148112509

+
Frame-shiftENST00000536800ENST00000361727SEMA3Cchr7

80545995

-CNTNAP2chr7

148112509

+
Frame-shiftENST00000536800ENST00000538075SEMA3Cchr7

80545995

-CNTNAP2chr7

148112509

+
Frame-shiftENST00000544525ENST00000361727SEMA3Cchr7

80545995

-CNTNAP2chr7

148112509

+
Frame-shiftENST00000544525ENST00000538075SEMA3Cchr7

80545995

-CNTNAP2chr7

148112509

+
In-frameENST00000265361ENST00000361727SEMA3Cchr7

80545995

-CNTNAP2chr7

148112509

+
In-frameENST00000265361ENST00000538075SEMA3Cchr7

80545995

-CNTNAP2chr7

148112509

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000265361SEMA3Cchr780545995-ENST00000361727CNTNAP2chr7148112509+6247665505864119
ENST00000265361SEMA3Cchr780545995-ENST00000538075CNTNAP2chr7148112509+1189665505864119

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000265361ENST00000361727SEMA3Cchr780545995-CNTNAP2chr7148112509+0.044047190.95595276
ENST00000265361ENST00000538075SEMA3Cchr780545995-CNTNAP2chr7148112509+0.0448774470.95512253

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Fusion Genomic Features for SEMA3C-CNTNAP2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
SEMA3Cchr780545994-CNTNAP2chr7148112508+4.75E-091
SEMA3Cchr780545994-CNTNAP2chr7148112508+4.75E-091

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for SEMA3C-CNTNAP2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr7:80545995/chr7:148112509)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.CNTNAP2

Q9UHC6

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Required for gap junction formation (Probable). Required, with CNTNAP1, for radial and longitudinal organization of myelinated axons. Plays a role in the formation of functional distinct domains critical for saltatory conduction of nerve impulses in myelinated nerve fibers. Demarcates the juxtaparanodal region of the axo-glial junction. {ECO:0000250|UniProtKB:Q9CPW0, ECO:0000305|PubMed:33238150}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneCNTNAP2chr7:80545995chr7:148112509ENST0000036172722241284_133112651332.0Topological domainCytoplasmic
TgeneCNTNAP2chr7:80545995chr7:148112509ENST0000036172722241263_128312651332.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSEMA3Cchr7:80545995chr7:148112509ENST00000265361-218724_74534752.0Compositional biasNote=Arg/Lys-rich (basic)
HgeneSEMA3Cchr7:80545995chr7:148112509ENST00000419255-218724_74534752.0Compositional biasNote=Arg/Lys-rich (basic)
HgeneSEMA3Cchr7:80545995chr7:148112509ENST00000265361-21828_51134752.0DomainSema
HgeneSEMA3Cchr7:80545995chr7:148112509ENST00000265361-218571_65534752.0DomainNote=Ig-like C2-type
HgeneSEMA3Cchr7:80545995chr7:148112509ENST00000419255-21828_51134752.0DomainSema
HgeneSEMA3Cchr7:80545995chr7:148112509ENST00000419255-218571_65534752.0DomainNote=Ig-like C2-type
TgeneCNTNAP2chr7:80545995chr7:148112509ENST0000036172722241055_121412651332.0DomainLaminin G-like 4
TgeneCNTNAP2chr7:80545995chr7:148112509ENST000003617272224216_36812651332.0DomainLaminin G-like 1
TgeneCNTNAP2chr7:80545995chr7:148112509ENST000003617272224401_55212651332.0DomainLaminin G-like 2
TgeneCNTNAP2chr7:80545995chr7:148112509ENST000003617272224554_59112651332.0DomainEGF-like 1
TgeneCNTNAP2chr7:80545995chr7:148112509ENST000003617272224592_79812651332.0DomainFibrinogen C-terminal
TgeneCNTNAP2chr7:80545995chr7:148112509ENST000003617272224799_96312651332.0DomainLaminin G-like 3
TgeneCNTNAP2chr7:80545995chr7:148112509ENST000003617272224963_100212651332.0DomainEGF-like 2
TgeneCNTNAP2chr7:80545995chr7:148112509ENST00000361727222428_126212651332.0Topological domainExtracellular


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Fusion Gene Sequence for SEMA3C-CNTNAP2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>80279_80279_1_SEMA3C-CNTNAP2_SEMA3C_chr7_80545995_ENST00000265361_CNTNAP2_chr7_148112509_ENST00000361727_length(transcript)=6247nt_BP=665nt
GGACTGCGAAAGGAGCAGGGTTGCGGAGCTAGGGCTCCAGCCTGCGGCCGCGCATTCTTGCGTCTGGCCAGCCGCGAGCTCTAAGGGTCG
GCCCCGCCCGGTCCGCCCCCGCGGCTCCCTGCCAGGCTCTCGCGGGCGCGCTCGGGGTGGGGCCTCGCGGCTGGCGGAGATGCGGCCGGG
GCTGCGCGGTGGTGATGCGAGCCTGCAGGGCGGCGCGCCGGGGCAGCCGGAGCCGCGCGCCGCGGCGCTGTAATCGGACACCAAGAGCGC
TCGCCCCCGGCCTCCGGCCACTTTCCATTCACTCCGAGGTGCTTGATTGAGCGACGCGGAGAAGAGCTCCGGGTGCCGCGGCACTGCAGC
GCTGAGATTCCTTTACAAAGAAACTCAGAGGACCGGGAAGAAAGAATTTCACCTTTGCGACGTGCTAGAAAATAAGGTCGTCTGGGAAAA
GGACTGGAGACACAAGCGCATCCAACCCCGGTAGCAAACTGATGACTTTTCCGTGCTGATTTCTTTCAACCTCGGTATTTTCCCTTGGAT
ATTAACTTGCATATCTGAAGAAATGGCATTCCGGACAATTTGCGTGTTGGTTGGAGTATTTATTTGTTCTATCTGTGTGAAAGGATCTTC
CCAGCCCCAAGCAAGAGTTTATTTAACATTTGATGGCGTCATTGCTGTGGTGATTTTCACCATCCTGTGCACCCTGGTCTTCCTGATCCG
GTACATGTTCCGCCACAAGGGCACCTACCATACCAACGAAGCAAAGGGGGCGGAGTCGGCAGAGAGCGCGGACGCCGCCATCATGAACAA
CGACCCCAACTTCACAGAGACCATTGATGAAAGCAAAAAGGAATGGCTCATTTGAGGGGTGGCTACTTGGCTATGGGATAGGGAGGAGGG
AATTACTAGGGAGGAGAGAAAGGGACAAAAGCACCCTGCTTCATACTCTTGAGCACATCCTTAAAATATCAGCACAAGTTGGGGGAGGCA
GGCAATGGAATATAATGGAATATTCTTGAGACTGATCACAAAAAAAAAAACCTTTTTAATATTTCTTTATAGCTGAGTTTTCCCTTCTGT
ATCAAAACAAAATAATACAAAAAATGCTTTTAGAGTTTAAGCAATGGTTGAAATTTGTAGGTACTATCTGTCTTATTTTGTGTGTGTTTA
GAGGTGTTCTAAAGACCCGTGGTAACAGGGCAAGTTTTCTACGTTTTTAAGAGCCCTTAGAACGTGGGTATTTTTTTTCTTGAGAAAAGC
TAATGCACCTACAGATGGCCCCCAACATTCTCTTCCTTTTGCTTCTAGTCAACCTTAATGGGCTGTTACAGAAACTAGTTCGTGTTTATA
TACTATTTCCTTTGATGTCCTATAAGTCGGAAAAGAAAGGGGCAAAGAGAACCTATTATTTGCCAGTTTTTAAGCAGAGCTCAATCTATG
CCAGCTCTCTGGCATCTGGGGTTCCTGACTGATACCAGCAGTTGAAGGAAGAGAGTGCATGGCACCTGGTGTGTAACGACACAATCAGCA
CAACTGGAGAGAGGCATTAAAGAACCAGGGAAGGTAGTTTGATTTTTCATTGAATTCTACAAGCTAATATTGTTCCACGTATGTAGTCTT
AGACCAATAGCTGTAACTATCAGCTGCAATACCATGGTGACCAGCTGTTACAAAAGATTTTTTCCTGTTTTATCTGAAACATACTGGATT
TATATATGTATAAGCGCCTCAATGGGGAATTAGAGCCAGATGTTATGATTTGTTTGCTCTTTTTCTTTTATAGTTTAGTTATAGCAAAAA
TATGGATAATTTCTAGTGAATGCATAAATTAGGTTGCGTTTCTTATTTTGCTTTAAATCTCTGGTAGTTTTTCCACCCCTGTGACACAAT
CCTAATAGACAGTGTCCTGTAAATGGACACAACACAATAAAGTCAAGTTATTATTGCTGTTACTCTGGATGATATGGAAAACACTGCCAT
ATTTTAAATCAACTACTCCACGTGTTTTTCCATCCAATCACACTGCTGTGATTCAGGGATCTTTCTTCTAAGACGGACACATTTGAACCT
CAGGTTCATCACAAACCTGGTACCTGTTGCTTCCCAGAGGATGGAGAAGTGTAGTTAATCACACCTCTTAGTTTAATCTGAAATCTTGAC
CCAGTTATTTAACAAATAAATACCTCATTGATTATATTTAAAAGTAATACACTTCCTGTAAACAAATGGGGACAATGCATCCAAAAAATC
TTTTTAAACAGATTACACAAAAATTATTTCCAGAAAGGCTACCATTTATCATCATTATATTTCAAGCCTCTTATACTTAATAAGCACTTT
CTAAAAAGTCTTGAGATCCCACCATTCTGAGGAATTCAATATGATCACTTTTTCCTTCTTTGCCTGGGAGAGGTTAAGAGGAGGTTTCGA
AGGTATAGATGCTATTGTTCTGATGGCCCGGCTGAATAAAATGGAAATTCTAGTTTGTTAGAATTATGCATTCTTTTTCAAGATTCTCAG
TGTGCCTAACTTATTGGAGCACATCAGTTTCTTGGGTAATGGAAAACATTACCTAGAGTTGCCAGTGGCACATTACACCAGTACAGAGCA
CATTCCAAAGGAGACATTGGACCAGTTAATTCCCATACAAGTCAAGGTAACAGAACAAAAGGGAATCCTGATGCCCTTTTACCATTGCTG
GTTGAGCTCAGGCACTGTCATGGACACCCTTAATTTTAAAAGGTTTTAATCATTCTTCTATAAAATACATTTAAAATGGAAAAATACTTA
ATATCACTAAATATCAGAACAATGTAACATTTACAAATGACATATTGAAAGCAAAGGCTGTTTTATTTAGCCAAGATGATTACCATTAGG
AGTTACTTTATGTATTGTTGAAAGCAAATTTTAAACATGATGTTTTAGAAGTGTTTCTGATTTTTAAACCTGGTTTACAGGTATTACTTC
TGCACTTACCAAATAATGCCAGATGGAAATTTATTATTTCTTGCAATTCCCATGATAGCTCTGTTCTTTATGCATTGTCTCAACACTTTC
CCTTTTTTCCCAAAATGAGTAGAGAATTAAAGCCACCCAAAACAGCTTCTGCTACTAAAATGTTCTCATCCTTTCTCCTCCCTCTCCTTT
TCCTGCCACAAAAGGTGAAAAATGAGATCCAATCCTCTCACCAAAATTTCAAACCTAGGACACTGGAATGACTGCAGGGATCAGTGGTTC
TCCCATATCACCATCAATTAAGACATATAGGACACTGTCTTCCTTCAAGAGGGTTACAATGTGGCCATCAGACAGGAAACCAAACGGTGG
ATAAAGTATTAAGTAACTAAGTGCCAAATAAATGCTGGAAATCTTGACCTCTCCTTGGGATTATGGGTGTAACAAAAATCCCTACATCTG
TTTATGAAGGCCATATTCAGTACATTTTAAATGGTAAATAATCTGTTTATGTGAAGAAAAAGAATTAAGTCTTTCTTCCAACTCTCTCCT
TGGATAGCCTAGCACAGTGCAGCCTCCATAACCATGACATTCCCGCCCAAGCTCTCAGTGCCTAATCCTGCTTTGTCATTCACATCTCAC
AAAATCTTGACATCTTACATTCCAATACATTATCAAGCAAGCACAAGTATGCTGGTAGTAGCCTCTTTAAATAATATGTATAGACAACAA
CAACGACAAAAAATAGACTGTTTTAAAGTTTCAGGGAAAGTTGGTGGCTGATTTAAAGTTGTGCAGGAAACATCTTCTGTGTATGAAGCA
AATGTCGATGTTTTGAAAAAAGCTAGGAGATGACTTTGAATGAATGCAAGGTTAGTGAGATCCTAAGCTCTCAAAATAGCATATTCCCTA
GAGCTCAAGAAAGCTGGTCCAGGAGGTTGAAAAAGCTATTTTGTTGTTAAATTATTTTCTGGCCCTTCTTAATATTTAAAAATGTATTTC
CCCTTGTGGCTTTCAACCACCTGCTCAAAAAAAGAGACTTGTTACATGAAAGTTTTCATTAAAGAGCTGAAAACAAGAATTTAGAGAGCC
ATTCCTAGAAAATGTCCTACTGCCCTGCATTTGACAAACAAGCATCCTTTACTAACAAGAGCAGGAATTCAGAGGCACAAGAAAAAGCAT
TGGCATGAGCCAAAGAGTCTGTCTTAATGTTACTTTTGAAAATCTGCTGAGCGGCCACCATATGCAGGCTGAGAGCTGGGCACAGGCGAA
GCCATTGGAAGCACTTCAGGAACAAGCACACAGCTGTGGGACTTGAACATGCAAGTGTTCAGGTTGTGTCAAGAAGCTTTTCTTTCCTTC
TATGATGGAATCTGTTCTTTTCTATCCTACTTTTTTCTCTCTTCCTCTCCTCACCACATTATACCCTGCTCTTACGCAGTAAACGTTTTA
ATGGCCCGTTTATGTCTCATGCCTCCAAACAACACTGAATTTGAAACCCCCCATTTTTTCTTTTCACCACCCTGTTGAGCAATTTTCCCA
AAAAAAGGGCAGCAATTATTAAATTGAATTCAAGTAAGCCAGCCAAAGATAGGTCCTAAATTGCTAGTCCCAGTAGAACCACCTGATCCT
AAACCAGTGCGAAACAAACAGTAACAATGTCCCCAGCTGACTTCAGCTAAGAACCAATGGCTCCTACCCCCGCCCCGCTTTTTTTTGTTG
TTTTTTGTTTTGTTTTGAGACGGAGTCTTGCTCTGTCCCCCAGGCTGGAGTGCACTGGCGCAATCTCGGGCTCACTGCAACCTCCTCCTC
CTCCCACATTGAGGCGATTCTCCTGCCTCAGCCTCCCAAGTAGCTGGGATTACAGGCACCCGCCATCACACCCAGCTAATTTTTTTTTTT
TTTTGTATTATTAGTAGAAGCCAGGTTTCACCATGTTGGCCAGGGTGGTCTCGAACTCCTGACCTCAAGTGATCCGTCCACCTCGGCCTT
GCAAATTGCTGGGATTACAGGTGTGAGCCACCGTGCCGAGCCAGCCCCATTTTTTAAATGATGTTTTGGTTAAGAGTGGACCATGAGAAT
TAGCTGACAGCATCCCCTTTCTCTCTCCCTGCCTTGGTGGGACCCTCCCTGTGTGACCTTGGTCAAGTCCTCGAACTTTTGTCCCGTATT
TAAGATGGAGCTGTTTTACCTACTTCATAAGACAGTTGCGAGGTGCCATTGATTCTTGACTGCAAAATACCTTGAAACCCTTATATAAAG
ACTGAAGTCAACGGAGCCTAGTGAAAGACTTACTTTGTGGCTTGTGGTTGAAAGTCACATCAAAAGACAAATGTGGCCACGTTCAGGAAT
TGGAGACTTACTGGCATGGCTCTACAGCTGCTCAGTTATTAATCATGCAGACTAACCTGTCAACACTGGGAGATGCAACATAGCAAAAGG
ACAGAGAAATTAGAATTTTTTGTGCAGAAAGCCCTAAATTCCCACCTGAATGTAACTTACAGCTCCCTTACCTACTCTCACACATGCCCT
CAAACATGCTAGATTGGCTTATACATAGGCCAACACAAAATACAAACGTGACGTGTTCATGTAGCCTAGTGGCTATATGCCTATTCTCCA
TGTACCCTGCATGGTAGTGCTGCAAACTTTAAAGTACATTTCTTTCACAGCAGTATTTTTTTTCATAAGTGGCATATAAATGTCATTCAA
TGAAATGGGGAAATCACGTTGAGAAGTTGGTCTGTCATCTCCCATTGAGCAAAGACTGGCAGGAGATAATAAAAATAAATATGGGCACAC
ATGTATTAATATACAGCACGCATTTACAAGTTTATTTTCCAGATAAAATTGTGCTATAAGAACAGCTCTACCAAGACAGTCTGCACCATT
TCCAAGTCTCAGTTAATTTACAGCAACTGCTGCTTTCGGAGATGGCTGTGAAAATATGGAAGTTCCTCTCAAGTAGGCCAAGAAACAGTT
CTAGATTTTACTAAGTTTTATTTTGTCAGGTTTTTTAAATTTTTTCAGTGAGCGTGGTGACTGCAGAGGTTAGTGCTGTGAAAAGCTGGG
CTAAATATTCTTTCTGTAAAGTCAAACAGGATTCCATCCCCTGTGAAATAACACAAAATTTCACTCTCTAAAAGCAACAGCATGTAAACT
AGAATGAAAGAAGGAAATTATGTACGTATGCCTAATATTCTTTGTGAATGTCTTTCATTTAACTAAAATTATATTAGAAACCAGATTGAT

>80279_80279_1_SEMA3C-CNTNAP2_SEMA3C_chr7_80545995_ENST00000265361_CNTNAP2_chr7_148112509_ENST00000361727_length(amino acids)=119AA_BP=53
MISFNLGIFPWILTCISEEMAFRTICVLVGVFICSICVKGSSQPQARVYLTFDGVIAVVIFTILCTLVFLIRYMFRHKGTYHTNEAKGAE

--------------------------------------------------------------
>80279_80279_2_SEMA3C-CNTNAP2_SEMA3C_chr7_80545995_ENST00000265361_CNTNAP2_chr7_148112509_ENST00000538075_length(transcript)=1189nt_BP=665nt
GGACTGCGAAAGGAGCAGGGTTGCGGAGCTAGGGCTCCAGCCTGCGGCCGCGCATTCTTGCGTCTGGCCAGCCGCGAGCTCTAAGGGTCG
GCCCCGCCCGGTCCGCCCCCGCGGCTCCCTGCCAGGCTCTCGCGGGCGCGCTCGGGGTGGGGCCTCGCGGCTGGCGGAGATGCGGCCGGG
GCTGCGCGGTGGTGATGCGAGCCTGCAGGGCGGCGCGCCGGGGCAGCCGGAGCCGCGCGCCGCGGCGCTGTAATCGGACACCAAGAGCGC
TCGCCCCCGGCCTCCGGCCACTTTCCATTCACTCCGAGGTGCTTGATTGAGCGACGCGGAGAAGAGCTCCGGGTGCCGCGGCACTGCAGC
GCTGAGATTCCTTTACAAAGAAACTCAGAGGACCGGGAAGAAAGAATTTCACCTTTGCGACGTGCTAGAAAATAAGGTCGTCTGGGAAAA
GGACTGGAGACACAAGCGCATCCAACCCCGGTAGCAAACTGATGACTTTTCCGTGCTGATTTCTTTCAACCTCGGTATTTTCCCTTGGAT
ATTAACTTGCATATCTGAAGAAATGGCATTCCGGACAATTTGCGTGTTGGTTGGAGTATTTATTTGTTCTATCTGTGTGAAAGGATCTTC
CCAGCCCCAAGCAAGAGTTTATTTAACATTTGATGGCGTCATTGCTGTGGTGATTTTCACCATCCTGTGCACCCTGGTCTTCCTGATCCG
GTACATGTTCCGCCACAAGGGCACCTACCATACCAACGAAGCAAAGGGGGCGGAGTCGGCAGAGAGCGCGGACGCCGCCATCATGAACAA
CGACCCCAACTTCACAGAGACCATTGATGAAAGCAAAAAGGAATGGCTCATTTGAGGGGTGGCTACTTGGCTATGGGATAGGGAGGAGGG
AATTACTAGGGAGGAGAGAAAGGGACAAAAGCACCCTGCTTCATACTCTTGAGCACATCCTTAAAATATCAGCACAAGTTGGGGGAGGCA
GGCAATGGAATATAATGGAATATTCTTGAGACTGATCACAAAAAAAAAAACCTTTTTAATATTTCTTTATAGCTGAGTTTTCCCTTCTGT
ATCAAAACAAAATAATACAAAAAATGCTTTTAGAGTTTAAGCAATGGTTGAAATTTGTAGGTACTATCTGTCTTATTTTGTGTGTGTTTA

>80279_80279_2_SEMA3C-CNTNAP2_SEMA3C_chr7_80545995_ENST00000265361_CNTNAP2_chr7_148112509_ENST00000538075_length(amino acids)=119AA_BP=53
MISFNLGIFPWILTCISEEMAFRTICVLVGVFICSICVKGSSQPQARVYLTFDGVIAVVIFTILCTLVFLIRYMFRHKGTYHTNEAKGAE

--------------------------------------------------------------

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Fusion Gene PPI Analysis for SEMA3C-CNTNAP2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for SEMA3C-CNTNAP2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for SEMA3C-CNTNAP2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource