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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:SEMA4B-CERS3 (FusionGDB2 ID:80308)

Fusion Gene Summary for SEMA4B-CERS3

check button Fusion gene summary
Fusion gene informationFusion gene name: SEMA4B-CERS3
Fusion gene ID: 80308
HgeneTgene
Gene symbol

SEMA4B

CERS3

Gene ID

10509

204219

Gene namesemaphorin 4Bceramide synthase 3
SynonymsSEMAC|SemCARCI9|LASS3
Cytomap

15q26.1

15q26.3

Type of geneprotein-codingprotein-coding
Descriptionsemaphorin-4Bsema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4Bsema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, 4Bsemaphorin-Cceramide synthase 3LAG1 homolog, ceramide synthase 3LAG1 longevity assurance homolog 3dihydroceramide synthase 3sphingosine N-acyltransferase CERS3
Modification date2020031320200313
UniProtAcc.

Q8IU89

Ensembl transtripts involved in fusion geneENST00000332496, ENST00000379122, 
ENST00000411539, ENST00000560263, 
ENST00000560944, ENST00000284382, 
ENST00000394113, ENST00000538112, 
Fusion gene scores* DoF score16 X 9 X 11=15848 X 7 X 7=392
# samples 2111
** MAII scorelog2(21/1584*10)=-2.91511110241349
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(11/392*10)=-1.83335013059055
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SEMA4B [Title/Abstract] AND CERS3 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointSEMA4B(90744967)-CERS3(100943070), # samples:1
SEMA4B(90761061)-CERS3(100943070), # samples:1
Anticipated loss of major functional domain due to fusion event.SEMA4B-CERS3 seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
SEMA4B-CERS3 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneCERS3

GO:0046513

ceramide biosynthetic process

17977534|22038835


check buttonFusion gene breakpoints across SEMA4B (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across CERS3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUADTCGA-J2-A4AD-01ASEMA4Bchr15

90744967

+CERS3chr15

100943070

-
ChimerDB4LUADTCGA-J2-A4AD-01ASEMA4Bchr15

90761061

-CERS3chr15

100943070

-


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Fusion Gene ORF analysis for SEMA4B-CERS3

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000332496ENST00000560944SEMA4Bchr15

90744967

+CERS3chr15

100943070

-
5CDS-5UTRENST00000332496ENST00000560944SEMA4Bchr15

90761061

-CERS3chr15

100943070

-
5CDS-5UTRENST00000379122ENST00000560944SEMA4Bchr15

90744967

+CERS3chr15

100943070

-
5CDS-5UTRENST00000379122ENST00000560944SEMA4Bchr15

90761061

-CERS3chr15

100943070

-
5CDS-5UTRENST00000411539ENST00000560944SEMA4Bchr15

90744967

+CERS3chr15

100943070

-
5CDS-5UTRENST00000411539ENST00000560944SEMA4Bchr15

90761061

-CERS3chr15

100943070

-
Frame-shiftENST00000332496ENST00000284382SEMA4Bchr15

90744967

+CERS3chr15

100943070

-
Frame-shiftENST00000332496ENST00000394113SEMA4Bchr15

90761061

-CERS3chr15

100943070

-
Frame-shiftENST00000332496ENST00000538112SEMA4Bchr15

90744967

+CERS3chr15

100943070

-
Frame-shiftENST00000332496ENST00000538112SEMA4Bchr15

90761061

-CERS3chr15

100943070

-
Frame-shiftENST00000379122ENST00000284382SEMA4Bchr15

90744967

+CERS3chr15

100943070

-
Frame-shiftENST00000379122ENST00000394113SEMA4Bchr15

90761061

-CERS3chr15

100943070

-
Frame-shiftENST00000379122ENST00000538112SEMA4Bchr15

90744967

+CERS3chr15

100943070

-
Frame-shiftENST00000379122ENST00000538112SEMA4Bchr15

90761061

-CERS3chr15

100943070

-
Frame-shiftENST00000411539ENST00000284382SEMA4Bchr15

90744967

+CERS3chr15

100943070

-
Frame-shiftENST00000411539ENST00000394113SEMA4Bchr15

90761061

-CERS3chr15

100943070

-
Frame-shiftENST00000411539ENST00000538112SEMA4Bchr15

90744967

+CERS3chr15

100943070

-
Frame-shiftENST00000411539ENST00000538112SEMA4Bchr15

90761061

-CERS3chr15

100943070

-
In-frameENST00000332496ENST00000284382SEMA4Bchr15

90761061

-CERS3chr15

100943070

-
In-frameENST00000332496ENST00000394113SEMA4Bchr15

90744967

+CERS3chr15

100943070

-
In-frameENST00000379122ENST00000284382SEMA4Bchr15

90761061

-CERS3chr15

100943070

-
In-frameENST00000379122ENST00000394113SEMA4Bchr15

90744967

+CERS3chr15

100943070

-
In-frameENST00000411539ENST00000284382SEMA4Bchr15

90761061

-CERS3chr15

100943070

-
In-frameENST00000411539ENST00000394113SEMA4Bchr15

90744967

+CERS3chr15

100943070

-
intron-3CDSENST00000560263ENST00000284382SEMA4Bchr15

90744967

+CERS3chr15

100943070

-
intron-3CDSENST00000560263ENST00000284382SEMA4Bchr15

90761061

-CERS3chr15

100943070

-
intron-3CDSENST00000560263ENST00000394113SEMA4Bchr15

90744967

+CERS3chr15

100943070

-
intron-3CDSENST00000560263ENST00000394113SEMA4Bchr15

90761061

-CERS3chr15

100943070

-
intron-3CDSENST00000560263ENST00000538112SEMA4Bchr15

90744967

+CERS3chr15

100943070

-
intron-3CDSENST00000560263ENST00000538112SEMA4Bchr15

90761061

-CERS3chr15

100943070

-
intron-5UTRENST00000560263ENST00000560944SEMA4Bchr15

90744967

+CERS3chr15

100943070

-
intron-5UTRENST00000560263ENST00000560944SEMA4Bchr15

90761061

-CERS3chr15

100943070

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000379122SEMA4Bchr1590744967+ENST00000394113CERS3chr15100943070-795440142462106
ENST00000332496SEMA4Bchr1590744967+ENST00000394113CERS3chr15100943070-75239799419106
ENST00000411539SEMA4Bchr1590744967+ENST00000394113CERS3chr15100943070-7724174051135
ENST00000379122SEMA4Bchr1590761061-ENST00000284382CERS3chr15100943070-3138667142819225
ENST00000332496SEMA4Bchr1590761061-ENST00000284382CERS3chr15100943070-309562499776225
ENST00000411539SEMA4Bchr1590761061-ENST00000284382CERS3chr15100943070-3115644191796201

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000379122ENST00000394113SEMA4Bchr1590744967+CERS3chr15100943070-0.599441050.40055895
ENST00000332496ENST00000394113SEMA4Bchr1590744967+CERS3chr15100943070-0.669695850.33030415
ENST00000411539ENST00000394113SEMA4Bchr1590744967+CERS3chr15100943070-0.602303450.3976965
ENST00000379122ENST00000284382SEMA4Bchr1590761061-CERS3chr15100943070-0.007624980.9923751
ENST00000332496ENST00000284382SEMA4Bchr1590761061-CERS3chr15100943070-0.0076690670.9923309
ENST00000411539ENST00000284382SEMA4Bchr1590761061-CERS3chr15100943070-0.0076222490.99237776

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Fusion Genomic Features for SEMA4B-CERS3


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for SEMA4B-CERS3


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr15:90744967/chr15:100943070)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.CERS3

Q8IU89

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Ceramide synthase that catalyzes formation of ceramide from sphinganine and acyl-CoA substrates, with high selectivity toward very-long (C22:0-C24:0) and ultra long chain (more than C26:0) as acyl donor (PubMed:17977534, PubMed:22038835, PubMed:26887952). It is crucial for the synthesis of ultra long-chain ceramides in the epidermis, to maintain epidermal lipid homeostasis and terminal differentiation (PubMed:23754960). {ECO:0000269|PubMed:17977534, ECO:0000269|PubMed:22038835, ECO:0000269|PubMed:23754960, ECO:0000269|PubMed:26887952}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneCERS3chr15:90744967chr15:100943070ENST000002843821113346_355333384.0Compositional biasNote=Poly-Glu
TgeneCERS3chr15:90744967chr15:100943070ENST000003941131214346_355333384.0Compositional biasNote=Poly-Glu
TgeneCERS3chr15:90744967chr15:100943070ENST000005381121113346_355333384.0Compositional biasNote=Poly-Glu
TgeneCERS3chr15:90761061chr15:100943070ENST000002843821113346_355333384.0Compositional biasNote=Poly-Glu
TgeneCERS3chr15:90761061chr15:100943070ENST000003941131214346_355333384.0Compositional biasNote=Poly-Glu
TgeneCERS3chr15:90761061chr15:100943070ENST000005381121113346_355333384.0Compositional biasNote=Poly-Glu

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSEMA4Bchr15:90744967chr15:100943070ENST00000379122+216758_78147738.0Compositional biasNote=Pro-rich
HgeneSEMA4Bchr15:90761061chr15:100943070ENST00000379122-416758_781123738.0Compositional biasNote=Pro-rich
HgeneSEMA4Bchr15:90744967chr15:100943070ENST00000379122+21647_52347738.0DomainSema
HgeneSEMA4Bchr15:90744967chr15:100943070ENST00000379122+216525_57947738.0DomainNote=PSI
HgeneSEMA4Bchr15:90744967chr15:100943070ENST00000379122+216604_66347738.0DomainNote=Ig-like C2-type
HgeneSEMA4Bchr15:90761061chr15:100943070ENST00000379122-41647_523123738.0DomainSema
HgeneSEMA4Bchr15:90761061chr15:100943070ENST00000379122-416525_579123738.0DomainNote=PSI
HgeneSEMA4Bchr15:90761061chr15:100943070ENST00000379122-416604_663123738.0DomainNote=Ig-like C2-type
HgeneSEMA4Bchr15:90744967chr15:100943070ENST00000379122+21644_71747738.0Topological domainExtracellular
HgeneSEMA4Bchr15:90744967chr15:100943070ENST00000379122+216739_83747738.0Topological domainCytoplasmic
HgeneSEMA4Bchr15:90761061chr15:100943070ENST00000379122-41644_717123738.0Topological domainExtracellular
HgeneSEMA4Bchr15:90761061chr15:100943070ENST00000379122-416739_837123738.0Topological domainCytoplasmic
HgeneSEMA4Bchr15:90744967chr15:100943070ENST00000379122+216718_73847738.0TransmembraneHelical
HgeneSEMA4Bchr15:90761061chr15:100943070ENST00000379122-416718_738123738.0TransmembraneHelical
TgeneCERS3chr15:90744967chr15:100943070ENST000002843821113130_331333384.0DomainTLC
TgeneCERS3chr15:90744967chr15:100943070ENST000003941131214130_331333384.0DomainTLC
TgeneCERS3chr15:90744967chr15:100943070ENST000005381121113130_331333384.0DomainTLC
TgeneCERS3chr15:90761061chr15:100943070ENST000002843821113130_331333384.0DomainTLC
TgeneCERS3chr15:90761061chr15:100943070ENST000003941131214130_331333384.0DomainTLC
TgeneCERS3chr15:90761061chr15:100943070ENST000005381121113130_331333384.0DomainTLC
TgeneCERS3chr15:90744967chr15:100943070ENST00000284382111366_127333384.0RegionHomeobox-like
TgeneCERS3chr15:90744967chr15:100943070ENST00000394113121466_127333384.0RegionHomeobox-like
TgeneCERS3chr15:90744967chr15:100943070ENST00000538112111366_127333384.0RegionHomeobox-like
TgeneCERS3chr15:90761061chr15:100943070ENST00000284382111366_127333384.0RegionHomeobox-like
TgeneCERS3chr15:90761061chr15:100943070ENST00000394113121466_127333384.0RegionHomeobox-like
TgeneCERS3chr15:90761061chr15:100943070ENST00000538112111366_127333384.0RegionHomeobox-like
TgeneCERS3chr15:90744967chr15:100943070ENST000002843821113319_383333384.0Topological domainCytoplasmic
TgeneCERS3chr15:90744967chr15:100943070ENST000003941131214319_383333384.0Topological domainCytoplasmic
TgeneCERS3chr15:90744967chr15:100943070ENST000005381121113319_383333384.0Topological domainCytoplasmic
TgeneCERS3chr15:90761061chr15:100943070ENST000002843821113319_383333384.0Topological domainCytoplasmic
TgeneCERS3chr15:90761061chr15:100943070ENST000003941131214319_383333384.0Topological domainCytoplasmic
TgeneCERS3chr15:90761061chr15:100943070ENST000005381121113319_383333384.0Topological domainCytoplasmic
TgeneCERS3chr15:90744967chr15:100943070ENST000002843821113139_159333384.0TransmembraneHelical
TgeneCERS3chr15:90744967chr15:100943070ENST000002843821113174_194333384.0TransmembraneHelical
TgeneCERS3chr15:90744967chr15:100943070ENST000002843821113205_225333384.0TransmembraneHelical
TgeneCERS3chr15:90744967chr15:100943070ENST000002843821113264_284333384.0TransmembraneHelical
TgeneCERS3chr15:90744967chr15:100943070ENST000002843821113298_318333384.0TransmembraneHelical
TgeneCERS3chr15:90744967chr15:100943070ENST00000284382111332_52333384.0TransmembraneHelical
TgeneCERS3chr15:90744967chr15:100943070ENST000003941131214139_159333384.0TransmembraneHelical
TgeneCERS3chr15:90744967chr15:100943070ENST000003941131214174_194333384.0TransmembraneHelical
TgeneCERS3chr15:90744967chr15:100943070ENST000003941131214205_225333384.0TransmembraneHelical
TgeneCERS3chr15:90744967chr15:100943070ENST000003941131214264_284333384.0TransmembraneHelical
TgeneCERS3chr15:90744967chr15:100943070ENST000003941131214298_318333384.0TransmembraneHelical
TgeneCERS3chr15:90744967chr15:100943070ENST00000394113121432_52333384.0TransmembraneHelical
TgeneCERS3chr15:90744967chr15:100943070ENST000005381121113139_159333384.0TransmembraneHelical
TgeneCERS3chr15:90744967chr15:100943070ENST000005381121113174_194333384.0TransmembraneHelical
TgeneCERS3chr15:90744967chr15:100943070ENST000005381121113205_225333384.0TransmembraneHelical
TgeneCERS3chr15:90744967chr15:100943070ENST000005381121113264_284333384.0TransmembraneHelical
TgeneCERS3chr15:90744967chr15:100943070ENST000005381121113298_318333384.0TransmembraneHelical
TgeneCERS3chr15:90744967chr15:100943070ENST00000538112111332_52333384.0TransmembraneHelical
TgeneCERS3chr15:90761061chr15:100943070ENST000002843821113139_159333384.0TransmembraneHelical
TgeneCERS3chr15:90761061chr15:100943070ENST000002843821113174_194333384.0TransmembraneHelical
TgeneCERS3chr15:90761061chr15:100943070ENST000002843821113205_225333384.0TransmembraneHelical
TgeneCERS3chr15:90761061chr15:100943070ENST000002843821113264_284333384.0TransmembraneHelical
TgeneCERS3chr15:90761061chr15:100943070ENST000002843821113298_318333384.0TransmembraneHelical
TgeneCERS3chr15:90761061chr15:100943070ENST00000284382111332_52333384.0TransmembraneHelical
TgeneCERS3chr15:90761061chr15:100943070ENST000003941131214139_159333384.0TransmembraneHelical
TgeneCERS3chr15:90761061chr15:100943070ENST000003941131214174_194333384.0TransmembraneHelical
TgeneCERS3chr15:90761061chr15:100943070ENST000003941131214205_225333384.0TransmembraneHelical
TgeneCERS3chr15:90761061chr15:100943070ENST000003941131214264_284333384.0TransmembraneHelical
TgeneCERS3chr15:90761061chr15:100943070ENST000003941131214298_318333384.0TransmembraneHelical
TgeneCERS3chr15:90761061chr15:100943070ENST00000394113121432_52333384.0TransmembraneHelical
TgeneCERS3chr15:90761061chr15:100943070ENST000005381121113139_159333384.0TransmembraneHelical
TgeneCERS3chr15:90761061chr15:100943070ENST000005381121113174_194333384.0TransmembraneHelical
TgeneCERS3chr15:90761061chr15:100943070ENST000005381121113205_225333384.0TransmembraneHelical
TgeneCERS3chr15:90761061chr15:100943070ENST000005381121113264_284333384.0TransmembraneHelical
TgeneCERS3chr15:90761061chr15:100943070ENST000005381121113298_318333384.0TransmembraneHelical
TgeneCERS3chr15:90761061chr15:100943070ENST00000538112111332_52333384.0TransmembraneHelical


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Fusion Gene Sequence for SEMA4B-CERS3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>80308_80308_1_SEMA4B-CERS3_SEMA4B_chr15_90744967_ENST00000332496_CERS3_chr15_100943070_ENST00000394113_length(transcript)=752nt_BP=397nt
CTCCGGGTCCCCAGGGGCTGCGCCGGGCCGGCCTGGCAAGGGGGACGAGTCAGTGGACACTCCAGGAAGAGCGGCCCCGCGGGGGGCGAT
GACCGTGCGCTGACCCTGACTCACTCCAGGTCCGGAGGCGGGGGCCCCCGGGGCGACTCGGGGGCGGACCGCGGGGCGGAGCTGCCGCCC
GTGAGTCCGGCCGAGCCACCTGAGCCCGAGCCGCGGGACACCGTCGCTCCTGCTCTCCGAATGCTGCGCACCGCGATGGGCCTGAGGAGC
TGGCTCGCCGCCCCATGGGGCGCGCTGCCGCCTCGGCCACCGCTGCTGCTGCTCCTGCTGCTGCTGCTCCTGCTGCAGCCGCCGCCTCCG
ACCTGGGCGCTCAGCCCCCGGATCAGCCTGCCTCTGGAGCATCCAGGATGTGAGGAGTGATGACGAGGATTATGAAGAGGAAGAGGAAGA
GGAAGAAGAAGAGGCTACCAAAGGCAAAGAGATGGATTGTTTAAAGAACGGCCTCAGGGCTGAGAGGCACCTCATTCCCAATGGCCAGCA
TGGCCATTAGCTGGAAGCCTACAGGACTCCCATGGCACAGCATGCTGCAAGTACTGTTGGCAGCCTGGCTTCCAGGCCCCACACCGACCC
CACATTCTGCCCTTCCCTCTTTCTCACCACCGCCTTCCCTCCCACCTAAGATGTGTTTACCAAAATGTTGTTAACTTGTGTTAAAATGTT

>80308_80308_1_SEMA4B-CERS3_SEMA4B_chr15_90744967_ENST00000332496_CERS3_chr15_100943070_ENST00000394113_length(amino acids)=106AA_BP=
MTLTHSRSGGGGPRGDSGADRGAELPPVSPAEPPEPEPRDTVAPALRMLRTAMGLRSWLAAPWGALPPRPPLLLLLLLLLLLQPPPPTWA

--------------------------------------------------------------
>80308_80308_2_SEMA4B-CERS3_SEMA4B_chr15_90744967_ENST00000379122_CERS3_chr15_100943070_ENST00000394113_length(transcript)=795nt_BP=440nt
ATTTCCGGGGACGCCGCGCCGGACTGAGGCTGTGCGCCCGAGACTCCGGGTCCCCAGGGGCTGCGCCGGGCCGGCCTGGCAAGGGGGACG
AGTCAGTGGACACTCCAGGAAGAGCGGCCCCGCGGGGGGCGATGACCGTGCGCTGACCCTGACTCACTCCAGGTCCGGAGGCGGGGGCCC
CCGGGGCGACTCGGGGGCGGACCGCGGGGCGGAGCTGCCGCCCGTGAGTCCGGCCGAGCCACCTGAGCCCGAGCCGCGGGACACCGTCGC
TCCTGCTCTCCGAATGCTGCGCACCGCGATGGGCCTGAGGAGCTGGCTCGCCGCCCCATGGGGCGCGCTGCCGCCTCGGCCACCGCTGCT
GCTGCTCCTGCTGCTGCTGCTCCTGCTGCAGCCGCCGCCTCCGACCTGGGCGCTCAGCCCCCGGATCAGCCTGCCTCTGGAGCATCCAGG
ATGTGAGGAGTGATGACGAGGATTATGAAGAGGAAGAGGAAGAGGAAGAAGAAGAGGCTACCAAAGGCAAAGAGATGGATTGTTTAAAGA
ACGGCCTCAGGGCTGAGAGGCACCTCATTCCCAATGGCCAGCATGGCCATTAGCTGGAAGCCTACAGGACTCCCATGGCACAGCATGCTG
CAAGTACTGTTGGCAGCCTGGCTTCCAGGCCCCACACCGACCCCACATTCTGCCCTTCCCTCTTTCTCACCACCGCCTTCCCTCCCACCT

>80308_80308_2_SEMA4B-CERS3_SEMA4B_chr15_90744967_ENST00000379122_CERS3_chr15_100943070_ENST00000394113_length(amino acids)=106AA_BP=
MTLTHSRSGGGGPRGDSGADRGAELPPVSPAEPPEPEPRDTVAPALRMLRTAMGLRSWLAAPWGALPPRPPLLLLLLLLLLLQPPPPTWA

--------------------------------------------------------------
>80308_80308_3_SEMA4B-CERS3_SEMA4B_chr15_90744967_ENST00000411539_CERS3_chr15_100943070_ENST00000394113_length(transcript)=772nt_BP=417nt
CGCCCTCCGCCGCTTGCGGGTGAGCTCTGCCCAAGCCGAGGCTGCGGGGCCGGCGCCGGCGGGAGGACTGCGGTGCCCCGCGGAGGGGCT
GAGTTTGCCAGGGCCCACTTGACCCTGTTTCCCACCTCCCGCCCCCCAGGTCCGGAGGCGGGGGCCCCCGGGGCGACTCGGGGGCGGACC
GCGGGGCGGAGCTGCCGCCCGTGAGTCCGGCCGAGCCACCTGAGCCCGAGCCGCGGGACACCGTCGCTCCTGCTCTCCGAATGCTGCGCA
CCGCGATGGGCCTGAGGAGCTGGCTCGCCGCCCCATGGGGCGCGCTGCCGCCTCGGCCACCGCTGCTGCTGCTCCTGCTGCTGCTGCTCC
TGCTGCAGCCGCCGCCTCCGACCTGGGCGCTCAGCCCCCGGATCAGCCTGCCTCTGGAGCATCCAGGATGTGAGGAGTGATGACGAGGAT
TATGAAGAGGAAGAGGAAGAGGAAGAAGAAGAGGCTACCAAAGGCAAAGAGATGGATTGTTTAAAGAACGGCCTCAGGGCTGAGAGGCAC
CTCATTCCCAATGGCCAGCATGGCCATTAGCTGGAAGCCTACAGGACTCCCATGGCACAGCATGCTGCAAGTACTGTTGGCAGCCTGGCT
TCCAGGCCCCACACCGACCCCACATTCTGCCCTTCCCTCTTTCTCACCACCGCCTTCCCTCCCACCTAAGATGTGTTTACCAAAATGTTG

>80308_80308_3_SEMA4B-CERS3_SEMA4B_chr15_90744967_ENST00000411539_CERS3_chr15_100943070_ENST00000394113_length(amino acids)=135AA_BP=
MIRGLSAQVGGGGCSRSSSSRSSSSGGRGGSAPHGAASQLLRPIAVRSIRRAGATVSRGSGSGGSAGLTGGSSAPRSAPESPRGPPPPDL

--------------------------------------------------------------
>80308_80308_4_SEMA4B-CERS3_SEMA4B_chr15_90761061_ENST00000332496_CERS3_chr15_100943070_ENST00000284382_length(transcript)=3095nt_BP=624nt
CTCCGGGTCCCCAGGGGCTGCGCCGGGCCGGCCTGGCAAGGGGGACGAGTCAGTGGACACTCCAGGAAGAGCGGCCCCGCGGGGGGCGAT
GACCGTGCGCTGACCCTGACTCACTCCAGGTCCGGAGGCGGGGGCCCCCGGGGCGACTCGGGGGCGGACCGCGGGGCGGAGCTGCCGCCC
GTGAGTCCGGCCGAGCCACCTGAGCCCGAGCCGCGGGACACCGTCGCTCCTGCTCTCCGAATGCTGCGCACCGCGATGGGCCTGAGGAGC
TGGCTCGCCGCCCCATGGGGCGCGCTGCCGCCTCGGCCACCGCTGCTGCTGCTCCTGCTGCTGCTGCTCCTGCTGCAGCCGCCGCCTCCG
ACCTGGGCGCTCAGCCCCCGGATCAGCCTGCCTCTGGGCTCTGAAGAGCGGCCATTCCTCAGATTCGAAGCTGAACACATCTCCAACTAC
ACAGCCCTTCTGCTGAGCAGGGATGGCAGGACCCTGTACGTGGGTGCTCGAGAGGCCCTCTTTGCACTCAGTAGCAACCTCAGCTTCCTG
CCAGGCGGGGAGTACCAGGAGCTGCTTTGGGGTGCAGACGCAGAGAAGAAACAGCAGTGCAGCTTCAAGGGCAAGGACCCACAGAGCATC
CAGGATGTGAGGAGTGATGACGAGGATTATGAAGAGGAAGAGGAAGAGGAAGAAGAAGAGGCTACCAAAGGCAAAGAGATGGATTGTTTA
AAGAACGGCCTCAGGGCTGAGAGGCACCTCATTCCCAATGGCCAGCATGGCCATTAGCTGGAAGCCTACAGGACTCCCATGGCACAGCAT
GCTGCAAGTACTGTTGGCAGCCTGGCTTCCAGGCCCCACACCGACCCCACATTCTGCCCTTCCCTCTTTCTCACCACCGCCTTCCCTCCC
ACCTAAGATGTGTTTACCAAAATGTTGTTAACTTGTGTTAAAATGTTAAATATAAGCATGCCCATGGATTTTTACTGCAGTTAGGACTCA
GACTGGTCAAAGATTTCAAAGATTTCTCCACAGAACCGTCTCAGTTCTAATTGCACTCCCTCATGCATGTCACTTTCTCAGGGGCTCGCT
TTGTTATAGACCCTTTCGCCTCGCCACCTTGCCTGTCCTCAGGACGCTTTCACAGGTGCTAAGTGATCTCATTTTTCCCAGGTGTGTTTG
GCCACAAAGAGCAGCTTCTTTCTCAAAATGAGTTAGAAGTGGCAGTGGGACAGGAGCGGAAGGACCACACCAGGAGACACTTCCATCCTG
AAGCTTAGGTGCCTCATCTCCACAGGGCGGTGGCAGTCCCTGCCTGCCACCCCACAGGGTTACAGCAAGGATTAAGTGAGATCACAGAAG
TTTAAGTACACACTGTCAACCGTGGGGTCATCGTGAACCAACCCACTTTGCACTGTTTGGGAGACAGAAACCTGGCTAAACATGGCACTG
CAATGGGCCTGAACAAAAGGCAGAATCTTTAAAAATTCCTCTTAAATGACTCTGGAGATACCTGGAAATGAAAGTGCCAAGAAAGGTGTT
CCATTTTATTTGCTAACTATTTATGCATTAGCTCCCCAAGGGTCATTCTCAGATTCTCCTGGAATTCTTCTCCCTCAGGACCCATGGTTC
AAGGAAGGAAGCTTAGGCCCTGTTCCTTCCTGTCCTTTGCTGGTCTTTCCCTTTTTTCCTTTCTAGGAGGGAAGCTTCTGTGCTGCTGCC
CTGAGCCCTTCCTTCAGGCCAGCACAGTACCTGGGGACCTCCACGGGGGAATGGGATCCAGGCCAGGTTGCTTGCTGAGCCTCATCACCC
AGGAGGCCTGAGCCTCTGGGGAGGGCACGCATGTACACTGCCAGACCCAGGGGAGATCTTGGGAACAGAGGATGCTACGTGATTTCCTCT
GGCTTCCAACCCAATCAGCCTGCATCACAGTGAAACACAACACAAAAGGCCATAAAAGGCATACCCCTGAGAAATGTTTAAGGGCAGGTG
CTAGAGTCAGTGCCAGCTCCCTGGGAGGAGGGATAGGGACGGGCAGATCAGTAGCCAGCTTGTCCTCACCCTCCGGAAGGGAGCACCGGA
GAAGACTTGCACACGTCCCTGCCTCCCTTGCGGCCTTGTCACCAGAGGGACACATCTCCTGGGCACAATGTGCAGGGCTGACCTGGGAGA
CTTCTCAGGTGGCTGCTGGCTGAGGAGAGGCCAGGCCTTCCCAAGGAAGACCCTGAGTAAAATCTGCATCTGTCCTCACCACCTGGCACA
GTCTCTCATAACGGTCAGATTTTGTATGTTCATCCTATTTATTCAGGGGCTCGTACTAGAAAGCCACAGGAGAGGTCGGCTTGTAGGGAC
TGGAAAATCAGCCCCAAGCAGAGCAGCTGCAGGGCCCCTGGAGCCGGAAGGACACTGCACAGAACAGACTGCGTTATTGTTATTTTTAAA
TAAAAATATACATTTGAAACCTTAAGGCTAAACAAAAATAAACAAAAAATCCTTTAGAATTCTTTCCACAACAATATCTCTTTCTGAGAA
ATTGTTACAAACAAGGTCAGATTTTCTCTGTATAACATTTGCTTTTATGAGGACAATATCATATGCATTATATGCATAATATGATATTAT
AAATCAAAATGCCTGCACCCACTTTAGGGTATAGCTATTGACTTATTATTAATATTATATTATTATTATTTTGCTGGAAGAAGGTCACAC
TAAGATATAATTTTTTATGTTTTCAGTTAACGGTATGCTTTCTTCTTTGCTTATTTGGTTTTTGTCTCTGTACCAAATATCTTCTTGCTT
AAGGTAGAAAAGTATTTGTTTACCTCTATCTCCAGTTTTTTTTCTTATTTGAATGTTGAAGGTAAAATTGATATACCAATTTTAACTATT
TCTGATACAGCTGAAAGCACTAAACTACTTCATAAGAAGTAGATACTCATTTTTGTAACACTATTTAGGGCTTTTGTGGTTAATTTTAAA
GGAAACCACTCTTTCTACAGGAAACAAGGGCTCAGGATTCTTCAGATGACCTTATAAAAATGCAGTCCACAGTGCTATCAATATTGTAAC

>80308_80308_4_SEMA4B-CERS3_SEMA4B_chr15_90761061_ENST00000332496_CERS3_chr15_100943070_ENST00000284382_length(amino acids)=225AA_BP=175
MTLTHSRSGGGGPRGDSGADRGAELPPVSPAEPPEPEPRDTVAPALRMLRTAMGLRSWLAAPWGALPPRPPLLLLLLLLLLLQPPPPTWA
LSPRISLPLGSEERPFLRFEAEHISNYTALLLSRDGRTLYVGAREALFALSSNLSFLPGGEYQELLWGADAEKKQQCSFKGKDPQSIQDV

--------------------------------------------------------------
>80308_80308_5_SEMA4B-CERS3_SEMA4B_chr15_90761061_ENST00000379122_CERS3_chr15_100943070_ENST00000284382_length(transcript)=3138nt_BP=667nt
ATTTCCGGGGACGCCGCGCCGGACTGAGGCTGTGCGCCCGAGACTCCGGGTCCCCAGGGGCTGCGCCGGGCCGGCCTGGCAAGGGGGACG
AGTCAGTGGACACTCCAGGAAGAGCGGCCCCGCGGGGGGCGATGACCGTGCGCTGACCCTGACTCACTCCAGGTCCGGAGGCGGGGGCCC
CCGGGGCGACTCGGGGGCGGACCGCGGGGCGGAGCTGCCGCCCGTGAGTCCGGCCGAGCCACCTGAGCCCGAGCCGCGGGACACCGTCGC
TCCTGCTCTCCGAATGCTGCGCACCGCGATGGGCCTGAGGAGCTGGCTCGCCGCCCCATGGGGCGCGCTGCCGCCTCGGCCACCGCTGCT
GCTGCTCCTGCTGCTGCTGCTCCTGCTGCAGCCGCCGCCTCCGACCTGGGCGCTCAGCCCCCGGATCAGCCTGCCTCTGGGCTCTGAAGA
GCGGCCATTCCTCAGATTCGAAGCTGAACACATCTCCAACTACACAGCCCTTCTGCTGAGCAGGGATGGCAGGACCCTGTACGTGGGTGC
TCGAGAGGCCCTCTTTGCACTCAGTAGCAACCTCAGCTTCCTGCCAGGCGGGGAGTACCAGGAGCTGCTTTGGGGTGCAGACGCAGAGAA
GAAACAGCAGTGCAGCTTCAAGGGCAAGGACCCACAGAGCATCCAGGATGTGAGGAGTGATGACGAGGATTATGAAGAGGAAGAGGAAGA
GGAAGAAGAAGAGGCTACCAAAGGCAAAGAGATGGATTGTTTAAAGAACGGCCTCAGGGCTGAGAGGCACCTCATTCCCAATGGCCAGCA
TGGCCATTAGCTGGAAGCCTACAGGACTCCCATGGCACAGCATGCTGCAAGTACTGTTGGCAGCCTGGCTTCCAGGCCCCACACCGACCC
CACATTCTGCCCTTCCCTCTTTCTCACCACCGCCTTCCCTCCCACCTAAGATGTGTTTACCAAAATGTTGTTAACTTGTGTTAAAATGTT
AAATATAAGCATGCCCATGGATTTTTACTGCAGTTAGGACTCAGACTGGTCAAAGATTTCAAAGATTTCTCCACAGAACCGTCTCAGTTC
TAATTGCACTCCCTCATGCATGTCACTTTCTCAGGGGCTCGCTTTGTTATAGACCCTTTCGCCTCGCCACCTTGCCTGTCCTCAGGACGC
TTTCACAGGTGCTAAGTGATCTCATTTTTCCCAGGTGTGTTTGGCCACAAAGAGCAGCTTCTTTCTCAAAATGAGTTAGAAGTGGCAGTG
GGACAGGAGCGGAAGGACCACACCAGGAGACACTTCCATCCTGAAGCTTAGGTGCCTCATCTCCACAGGGCGGTGGCAGTCCCTGCCTGC
CACCCCACAGGGTTACAGCAAGGATTAAGTGAGATCACAGAAGTTTAAGTACACACTGTCAACCGTGGGGTCATCGTGAACCAACCCACT
TTGCACTGTTTGGGAGACAGAAACCTGGCTAAACATGGCACTGCAATGGGCCTGAACAAAAGGCAGAATCTTTAAAAATTCCTCTTAAAT
GACTCTGGAGATACCTGGAAATGAAAGTGCCAAGAAAGGTGTTCCATTTTATTTGCTAACTATTTATGCATTAGCTCCCCAAGGGTCATT
CTCAGATTCTCCTGGAATTCTTCTCCCTCAGGACCCATGGTTCAAGGAAGGAAGCTTAGGCCCTGTTCCTTCCTGTCCTTTGCTGGTCTT
TCCCTTTTTTCCTTTCTAGGAGGGAAGCTTCTGTGCTGCTGCCCTGAGCCCTTCCTTCAGGCCAGCACAGTACCTGGGGACCTCCACGGG
GGAATGGGATCCAGGCCAGGTTGCTTGCTGAGCCTCATCACCCAGGAGGCCTGAGCCTCTGGGGAGGGCACGCATGTACACTGCCAGACC
CAGGGGAGATCTTGGGAACAGAGGATGCTACGTGATTTCCTCTGGCTTCCAACCCAATCAGCCTGCATCACAGTGAAACACAACACAAAA
GGCCATAAAAGGCATACCCCTGAGAAATGTTTAAGGGCAGGTGCTAGAGTCAGTGCCAGCTCCCTGGGAGGAGGGATAGGGACGGGCAGA
TCAGTAGCCAGCTTGTCCTCACCCTCCGGAAGGGAGCACCGGAGAAGACTTGCACACGTCCCTGCCTCCCTTGCGGCCTTGTCACCAGAG
GGACACATCTCCTGGGCACAATGTGCAGGGCTGACCTGGGAGACTTCTCAGGTGGCTGCTGGCTGAGGAGAGGCCAGGCCTTCCCAAGGA
AGACCCTGAGTAAAATCTGCATCTGTCCTCACCACCTGGCACAGTCTCTCATAACGGTCAGATTTTGTATGTTCATCCTATTTATTCAGG
GGCTCGTACTAGAAAGCCACAGGAGAGGTCGGCTTGTAGGGACTGGAAAATCAGCCCCAAGCAGAGCAGCTGCAGGGCCCCTGGAGCCGG
AAGGACACTGCACAGAACAGACTGCGTTATTGTTATTTTTAAATAAAAATATACATTTGAAACCTTAAGGCTAAACAAAAATAAACAAAA
AATCCTTTAGAATTCTTTCCACAACAATATCTCTTTCTGAGAAATTGTTACAAACAAGGTCAGATTTTCTCTGTATAACATTTGCTTTTA
TGAGGACAATATCATATGCATTATATGCATAATATGATATTATAAATCAAAATGCCTGCACCCACTTTAGGGTATAGCTATTGACTTATT
ATTAATATTATATTATTATTATTTTGCTGGAAGAAGGTCACACTAAGATATAATTTTTTATGTTTTCAGTTAACGGTATGCTTTCTTCTT
TGCTTATTTGGTTTTTGTCTCTGTACCAAATATCTTCTTGCTTAAGGTAGAAAAGTATTTGTTTACCTCTATCTCCAGTTTTTTTTCTTA
TTTGAATGTTGAAGGTAAAATTGATATACCAATTTTAACTATTTCTGATACAGCTGAAAGCACTAAACTACTTCATAAGAAGTAGATACT
CATTTTTGTAACACTATTTAGGGCTTTTGTGGTTAATTTTAAAGGAAACCACTCTTTCTACAGGAAACAAGGGCTCAGGATTCTTCAGAT

>80308_80308_5_SEMA4B-CERS3_SEMA4B_chr15_90761061_ENST00000379122_CERS3_chr15_100943070_ENST00000284382_length(amino acids)=225AA_BP=175
MTLTHSRSGGGGPRGDSGADRGAELPPVSPAEPPEPEPRDTVAPALRMLRTAMGLRSWLAAPWGALPPRPPLLLLLLLLLLLQPPPPTWA
LSPRISLPLGSEERPFLRFEAEHISNYTALLLSRDGRTLYVGAREALFALSSNLSFLPGGEYQELLWGADAEKKQQCSFKGKDPQSIQDV

--------------------------------------------------------------
>80308_80308_6_SEMA4B-CERS3_SEMA4B_chr15_90761061_ENST00000411539_CERS3_chr15_100943070_ENST00000284382_length(transcript)=3115nt_BP=644nt
CGCCCTCCGCCGCTTGCGGGTGAGCTCTGCCCAAGCCGAGGCTGCGGGGCCGGCGCCGGCGGGAGGACTGCGGTGCCCCGCGGAGGGGCT
GAGTTTGCCAGGGCCCACTTGACCCTGTTTCCCACCTCCCGCCCCCCAGGTCCGGAGGCGGGGGCCCCCGGGGCGACTCGGGGGCGGACC
GCGGGGCGGAGCTGCCGCCCGTGAGTCCGGCCGAGCCACCTGAGCCCGAGCCGCGGGACACCGTCGCTCCTGCTCTCCGAATGCTGCGCA
CCGCGATGGGCCTGAGGAGCTGGCTCGCCGCCCCATGGGGCGCGCTGCCGCCTCGGCCACCGCTGCTGCTGCTCCTGCTGCTGCTGCTCC
TGCTGCAGCCGCCGCCTCCGACCTGGGCGCTCAGCCCCCGGATCAGCCTGCCTCTGGGCTCTGAAGAGCGGCCATTCCTCAGATTCGAAG
CTGAACACATCTCCAACTACACAGCCCTTCTGCTGAGCAGGGATGGCAGGACCCTGTACGTGGGTGCTCGAGAGGCCCTCTTTGCACTCA
GTAGCAACCTCAGCTTCCTGCCAGGCGGGGAGTACCAGGAGCTGCTTTGGGGTGCAGACGCAGAGAAGAAACAGCAGTGCAGCTTCAAGG
GCAAGGACCCACAGAGCATCCAGGATGTGAGGAGTGATGACGAGGATTATGAAGAGGAAGAGGAAGAGGAAGAAGAAGAGGCTACCAAAG
GCAAAGAGATGGATTGTTTAAAGAACGGCCTCAGGGCTGAGAGGCACCTCATTCCCAATGGCCAGCATGGCCATTAGCTGGAAGCCTACA
GGACTCCCATGGCACAGCATGCTGCAAGTACTGTTGGCAGCCTGGCTTCCAGGCCCCACACCGACCCCACATTCTGCCCTTCCCTCTTTC
TCACCACCGCCTTCCCTCCCACCTAAGATGTGTTTACCAAAATGTTGTTAACTTGTGTTAAAATGTTAAATATAAGCATGCCCATGGATT
TTTACTGCAGTTAGGACTCAGACTGGTCAAAGATTTCAAAGATTTCTCCACAGAACCGTCTCAGTTCTAATTGCACTCCCTCATGCATGT
CACTTTCTCAGGGGCTCGCTTTGTTATAGACCCTTTCGCCTCGCCACCTTGCCTGTCCTCAGGACGCTTTCACAGGTGCTAAGTGATCTC
ATTTTTCCCAGGTGTGTTTGGCCACAAAGAGCAGCTTCTTTCTCAAAATGAGTTAGAAGTGGCAGTGGGACAGGAGCGGAAGGACCACAC
CAGGAGACACTTCCATCCTGAAGCTTAGGTGCCTCATCTCCACAGGGCGGTGGCAGTCCCTGCCTGCCACCCCACAGGGTTACAGCAAGG
ATTAAGTGAGATCACAGAAGTTTAAGTACACACTGTCAACCGTGGGGTCATCGTGAACCAACCCACTTTGCACTGTTTGGGAGACAGAAA
CCTGGCTAAACATGGCACTGCAATGGGCCTGAACAAAAGGCAGAATCTTTAAAAATTCCTCTTAAATGACTCTGGAGATACCTGGAAATG
AAAGTGCCAAGAAAGGTGTTCCATTTTATTTGCTAACTATTTATGCATTAGCTCCCCAAGGGTCATTCTCAGATTCTCCTGGAATTCTTC
TCCCTCAGGACCCATGGTTCAAGGAAGGAAGCTTAGGCCCTGTTCCTTCCTGTCCTTTGCTGGTCTTTCCCTTTTTTCCTTTCTAGGAGG
GAAGCTTCTGTGCTGCTGCCCTGAGCCCTTCCTTCAGGCCAGCACAGTACCTGGGGACCTCCACGGGGGAATGGGATCCAGGCCAGGTTG
CTTGCTGAGCCTCATCACCCAGGAGGCCTGAGCCTCTGGGGAGGGCACGCATGTACACTGCCAGACCCAGGGGAGATCTTGGGAACAGAG
GATGCTACGTGATTTCCTCTGGCTTCCAACCCAATCAGCCTGCATCACAGTGAAACACAACACAAAAGGCCATAAAAGGCATACCCCTGA
GAAATGTTTAAGGGCAGGTGCTAGAGTCAGTGCCAGCTCCCTGGGAGGAGGGATAGGGACGGGCAGATCAGTAGCCAGCTTGTCCTCACC
CTCCGGAAGGGAGCACCGGAGAAGACTTGCACACGTCCCTGCCTCCCTTGCGGCCTTGTCACCAGAGGGACACATCTCCTGGGCACAATG
TGCAGGGCTGACCTGGGAGACTTCTCAGGTGGCTGCTGGCTGAGGAGAGGCCAGGCCTTCCCAAGGAAGACCCTGAGTAAAATCTGCATC
TGTCCTCACCACCTGGCACAGTCTCTCATAACGGTCAGATTTTGTATGTTCATCCTATTTATTCAGGGGCTCGTACTAGAAAGCCACAGG
AGAGGTCGGCTTGTAGGGACTGGAAAATCAGCCCCAAGCAGAGCAGCTGCAGGGCCCCTGGAGCCGGAAGGACACTGCACAGAACAGACT
GCGTTATTGTTATTTTTAAATAAAAATATACATTTGAAACCTTAAGGCTAAACAAAAATAAACAAAAAATCCTTTAGAATTCTTTCCACA
ACAATATCTCTTTCTGAGAAATTGTTACAAACAAGGTCAGATTTTCTCTGTATAACATTTGCTTTTATGAGGACAATATCATATGCATTA
TATGCATAATATGATATTATAAATCAAAATGCCTGCACCCACTTTAGGGTATAGCTATTGACTTATTATTAATATTATATTATTATTATT
TTGCTGGAAGAAGGTCACACTAAGATATAATTTTTTATGTTTTCAGTTAACGGTATGCTTTCTTCTTTGCTTATTTGGTTTTTGTCTCTG
TACCAAATATCTTCTTGCTTAAGGTAGAAAAGTATTTGTTTACCTCTATCTCCAGTTTTTTTTCTTATTTGAATGTTGAAGGTAAAATTG
ATATACCAATTTTAACTATTTCTGATACAGCTGAAAGCACTAAACTACTTCATAAGAAGTAGATACTCATTTTTGTAACACTATTTAGGG
CTTTTGTGGTTAATTTTAAAGGAAACCACTCTTTCTACAGGAAACAAGGGCTCAGGATTCTTCAGATGACCTTATAAAAATGCAGTCCAC

>80308_80308_6_SEMA4B-CERS3_SEMA4B_chr15_90761061_ENST00000411539_CERS3_chr15_100943070_ENST00000284382_length(amino acids)=201AA_BP=151
MPPVSPAEPPEPEPRDTVAPALRMLRTAMGLRSWLAAPWGALPPRPPLLLLLLLLLLLQPPPPTWALSPRISLPLGSEERPFLRFEAEHI
SNYTALLLSRDGRTLYVGAREALFALSSNLSFLPGGEYQELLWGADAEKKQQCSFKGKDPQSIQDVRSDDEDYEEEEEEEEEEATKGKEM

--------------------------------------------------------------

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Fusion Gene PPI Analysis for SEMA4B-CERS3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for SEMA4B-CERS3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for SEMA4B-CERS3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource