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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:SEMA4B-GLUD1 (FusionGDB2 ID:80311)

Fusion Gene Summary for SEMA4B-GLUD1

check button Fusion gene summary
Fusion gene informationFusion gene name: SEMA4B-GLUD1
Fusion gene ID: 80311
HgeneTgene
Gene symbol

SEMA4B

GLUD1

Gene ID

10509

2746

Gene namesemaphorin 4Bglutamate dehydrogenase 1
SynonymsSEMAC|SemCGDH|GDH1|GLUD
Cytomap

15q26.1

10q23.2

Type of geneprotein-codingprotein-coding
Descriptionsemaphorin-4Bsema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4Bsema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, 4Bsemaphorin-Cglutamate dehydrogenase 1, mitochondrialepididymis secretory sperm binding proteinepididymis tissue sperm binding protein Li 18mPglutamate dehydrogenase (NAD(P)+)
Modification date2020031320200329
UniProtAcc.

P00367

Ensembl transtripts involved in fusion geneENST00000332496, ENST00000379122, 
ENST00000411539, ENST00000560263, 
ENST00000465164, ENST00000277865, 
ENST00000537649, ENST00000544149, 
Fusion gene scores* DoF score16 X 9 X 11=158410 X 7 X 8=560
# samples 2111
** MAII scorelog2(21/1584*10)=-2.91511110241349
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(11/560*10)=-2.34792330342031
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SEMA4B [Title/Abstract] AND GLUD1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointSEMA4B(90744967)-GLUD1(88827914), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneGLUD1

GO:0006537

glutamate biosynthetic process

11032875

TgeneGLUD1

GO:0006538

glutamate catabolic process

6121377|11032875


check buttonFusion gene breakpoints across SEMA4B (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across GLUD1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4ESCATCGA-IG-A5B8SEMA4Bchr15

90744967

+GLUD1chr10

88827914

-


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Fusion Gene ORF analysis for SEMA4B-GLUD1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000332496ENST00000465164SEMA4Bchr15

90744967

+GLUD1chr10

88827914

-
5CDS-intronENST00000379122ENST00000465164SEMA4Bchr15

90744967

+GLUD1chr10

88827914

-
5CDS-intronENST00000411539ENST00000465164SEMA4Bchr15

90744967

+GLUD1chr10

88827914

-
In-frameENST00000332496ENST00000277865SEMA4Bchr15

90744967

+GLUD1chr10

88827914

-
In-frameENST00000332496ENST00000537649SEMA4Bchr15

90744967

+GLUD1chr10

88827914

-
In-frameENST00000332496ENST00000544149SEMA4Bchr15

90744967

+GLUD1chr10

88827914

-
In-frameENST00000379122ENST00000277865SEMA4Bchr15

90744967

+GLUD1chr10

88827914

-
In-frameENST00000379122ENST00000537649SEMA4Bchr15

90744967

+GLUD1chr10

88827914

-
In-frameENST00000379122ENST00000544149SEMA4Bchr15

90744967

+GLUD1chr10

88827914

-
In-frameENST00000411539ENST00000277865SEMA4Bchr15

90744967

+GLUD1chr10

88827914

-
In-frameENST00000411539ENST00000537649SEMA4Bchr15

90744967

+GLUD1chr10

88827914

-
In-frameENST00000411539ENST00000544149SEMA4Bchr15

90744967

+GLUD1chr10

88827914

-
intron-3CDSENST00000560263ENST00000277865SEMA4Bchr15

90744967

+GLUD1chr10

88827914

-
intron-3CDSENST00000560263ENST00000537649SEMA4Bchr15

90744967

+GLUD1chr10

88827914

-
intron-3CDSENST00000560263ENST00000544149SEMA4Bchr15

90744967

+GLUD1chr10

88827914

-
intron-intronENST00000560263ENST00000465164SEMA4Bchr15

90744967

+GLUD1chr10

88827914

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000379122SEMA4Bchr1590744967+ENST00000277865GLUD1chr1088827914-27364401421470442
ENST00000379122SEMA4Bchr1590744967+ENST00000537649GLUD1chr1088827914-27324401421470442
ENST00000379122SEMA4Bchr1590744967+ENST00000544149GLUD1chr1088827914-16214401421470442
ENST00000332496SEMA4Bchr1590744967+ENST00000277865GLUD1chr1088827914-2693397991427442
ENST00000332496SEMA4Bchr1590744967+ENST00000537649GLUD1chr1088827914-2689397991427442
ENST00000332496SEMA4Bchr1590744967+ENST00000544149GLUD1chr1088827914-1578397991427442
ENST00000411539SEMA4Bchr1590744967+ENST00000277865GLUD1chr1088827914-27134171911447418
ENST00000411539SEMA4Bchr1590744967+ENST00000537649GLUD1chr1088827914-27094171911447418
ENST00000411539SEMA4Bchr1590744967+ENST00000544149GLUD1chr1088827914-15984171911447418

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000379122ENST00000277865SEMA4Bchr1590744967+GLUD1chr1088827914-0.0008056870.9991943
ENST00000379122ENST00000537649SEMA4Bchr1590744967+GLUD1chr1088827914-0.0008116040.99918836
ENST00000379122ENST00000544149SEMA4Bchr1590744967+GLUD1chr1088827914-0.0022928690.9977071
ENST00000332496ENST00000277865SEMA4Bchr1590744967+GLUD1chr1088827914-0.0007845350.9992155
ENST00000332496ENST00000537649SEMA4Bchr1590744967+GLUD1chr1088827914-0.0007897330.99921024
ENST00000332496ENST00000544149SEMA4Bchr1590744967+GLUD1chr1088827914-0.002301560.9976985
ENST00000411539ENST00000277865SEMA4Bchr1590744967+GLUD1chr1088827914-0.0008338560.99916613
ENST00000411539ENST00000537649SEMA4Bchr1590744967+GLUD1chr1088827914-0.0008413420.9991586
ENST00000411539ENST00000544149SEMA4Bchr1590744967+GLUD1chr1088827914-0.002523410.99747664

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Fusion Genomic Features for SEMA4B-GLUD1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for SEMA4B-GLUD1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr15:90744967/chr10:88827914)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.GLUD1

P00367

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Mitochondrial glutamate dehydrogenase that catalyzes the conversion of L-glutamate into alpha-ketoglutarate. Plays a key role in glutamine anaplerosis by producing alpha-ketoglutarate, an important intermediate in the tricarboxylic acid cycle (PubMed:11032875, PubMed:16959573, PubMed:11254391, PubMed:16023112). Plays a role in insulin homeostasis (PubMed:9571255, PubMed:11297618). May be involved in learning and memory reactions by increasing the turnover of the excitatory neurotransmitter glutamate (By similarity). {ECO:0000250|UniProtKB:P10860, ECO:0000269|PubMed:11032875, ECO:0000269|PubMed:11254391, ECO:0000269|PubMed:11297618, ECO:0000269|PubMed:16023112, ECO:0000269|PubMed:16959573, ECO:0000269|PubMed:9571255}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSEMA4Bchr15:90744967chr10:88827914ENST00000379122+216758_78147738.0Compositional biasNote=Pro-rich
HgeneSEMA4Bchr15:90744967chr10:88827914ENST00000379122+21647_52347738.0DomainSema
HgeneSEMA4Bchr15:90744967chr10:88827914ENST00000379122+216525_57947738.0DomainNote=PSI
HgeneSEMA4Bchr15:90744967chr10:88827914ENST00000379122+216604_66347738.0DomainNote=Ig-like C2-type
HgeneSEMA4Bchr15:90744967chr10:88827914ENST00000379122+21644_71747738.0Topological domainExtracellular
HgeneSEMA4Bchr15:90744967chr10:88827914ENST00000379122+216739_83747738.0Topological domainCytoplasmic
HgeneSEMA4Bchr15:90744967chr10:88827914ENST00000379122+216718_73847738.0TransmembraneHelical
TgeneGLUD1chr15:90744967chr10:88827914ENST00000277865313141_143215559.0Nucleotide bindingNAD


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Fusion Gene Sequence for SEMA4B-GLUD1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>80311_80311_1_SEMA4B-GLUD1_SEMA4B_chr15_90744967_ENST00000332496_GLUD1_chr10_88827914_ENST00000277865_length(transcript)=2693nt_BP=397nt
CTCCGGGTCCCCAGGGGCTGCGCCGGGCCGGCCTGGCAAGGGGGACGAGTCAGTGGACACTCCAGGAAGAGCGGCCCCGCGGGGGGCGAT
GACCGTGCGCTGACCCTGACTCACTCCAGGTCCGGAGGCGGGGGCCCCCGGGGCGACTCGGGGGCGGACCGCGGGGCGGAGCTGCCGCCC
GTGAGTCCGGCCGAGCCACCTGAGCCCGAGCCGCGGGACACCGTCGCTCCTGCTCTCCGAATGCTGCGCACCGCGATGGGCCTGAGGAGC
TGGCTCGCCGCCCCATGGGGCGCGCTGCCGCCTCGGCCACCGCTGCTGCTGCTCCTGCTGCTGCTGCTCCTGCTGCAGCCGCCGCCTCCG
ACCTGGGCGCTCAGCCCCCGGATCAGCCTGCCTCTGGGTCCTGGCATTGATGTGCCTGCTCCAGACATGAGCACAGGTGAGCGGGAGATG
TCCTGGATCGCTGATACCTATGCCAGCACCATAGGGCACTATGATATTAATGCACACGCCTGTGTTACTGGTAAACCCATCAGCCAAGGG
GGAATCCATGGACGCATCTCTGCTACTGGCCGTGGTGTCTTCCATGGGATTGAAAATTTCATCAATGAAGCTTCTTACATGAGCATTTTA
GGAATGACACCAGGGTTTGGAGATAAAACATTTGTTGTTCAGGGATTTGGTAATGTGGGCCTACACTCTATGAGATATTTACATCGTTTT
GGTGCTAAATGTATTGCTGTTGGTGAGTCTGATGGGAGTATATGGAATCCAGATGGTATTGACCCAAAGGAACTGGAAGACTTCAAATTG
CAACATGGGTCCATTCTGGGCTTCCCCAAGGCAAAGCCCTATGAAGGAAGCATCTTGGAGGCCGACTGTGACATACTGATCCCAGCTGCC
AGTGAGAAGCAGTTGACCAAATCCAACGCACCCAGAGTCAAAGCCAAGATCATTGCTGAAGGTGCCAATGGGCCAACAACTCCAGAAGCT
GACAAGATCTTCCTGGAGAGAAACATTATGGTTATTCCAGATCTCTACTTGAATGCTGGAGGAGTGACAGTATCTTACTTTGAGTGGCTG
AAGAATCTAAATCATGTCAGCTATGGCCGTTTGACCTTCAAATATGAAAGGGATTCTAACTACCACTTGCTCATGTCTGTTCAAGAGAGT
TTAGAAAGAAAATTTGGAAAGCATGGTGGAACTATTCCCATTGTACCCACGGCAGAGTTCCAAGACAGGATATCGGGTGCATCTGAGAAA
GACATCGTGCACTCTGGCTTGGCATACACAATGGAGCGTTCTGCCAGGCAAATTATGCGCACAGCCATGAAGTATAACCTGGGATTGGAC
CTGAGAACAGCTGCCTATGTTAATGCCATTGAGAAAGTCTTCAAAGTGTACAATGAAGCTGGTGTGACCTTCACATAGATGGATCATGGC
TGACTTCCTCACTATCCTCTTCACATGTAACTTCTGCAGACCTATCACAAGTTTACATGTAACCACAGAAATCCCTTTCTCTCCTGACTC
ATTAATAATGGATACCATTCTCAACAAGTCAATCCAAGTCAGCCCGTTAAGGAGAAAGAAATTAAGGTTAGCGGATCATGTACAAGCTGA
GTGTGAAAGTAGAAATCACCTACACCAGAGAGCCATTTTGGTATTTTGCCTTTAAATAAAAAGCCTCCTTTATCTGGCTGTGCAGCCTTG
CTCTGTGGCTTTTCCCAACACAATCAGTGCTAGTGCTGGGGAGGAACAGTCAAGAGCAGTCAGTTGCTTGCTTATTTTTTCTGGATGAGT
CTGGGACACACTGTAACTTTAACACATTTAAGAAGTAGGTGTGTGGCCTTTTCAGAAGGTGGCATGGTCCTCAAGTGAGTTCTTAGTATT
TTATATCAGCAAAATAATTCAATTTTGCAGGTTGCAAACAAATATAAAACCTGTTTCTGTTTATGAATATTATTCTTTTAGAATAGAATA
AGTACATGCTGCTGTAATAAAATTGCCTTTAATCACTTAACAAGCCTAACCTTGACTCAAACAGTGAATGCCTATAGAAATAATAAATGA
AAAAAACTAGTATTTTTATATCATAAAACAATGTCATTTATAGCTTATCATTCATGTATTGTCCAGCAGACATTAAAAGCCCTGTGGATA
ATTAAGTTATCTTCATACCTGCAAAATGGTGGAGGCTATTTTCATTAAAACTGTCAGAATTTGCTTACTATAATTATGATACAGTCCAAA
GAATGCAGTCACTTTTTATCATGTTAACTAATTGTTCTCTTTTGAAGATCTATGGTTGACTAATTAAACAATAATTCAAGTAGAGTGTCC
CAGAAAAAAACCACTTGGGCTCCCTGTTTGGAGTCTGGCTGGCTCTGAGCATTGCCAATGGCCCCTACTCACCTGACTTTGTATCCTCTC
CTTTTAGAGGCTTTGCATTCTGCACCCAGCTTCACTAACAGTGGGCTGAAAACATCCTTGGGTTGAGTGTTTCATTTGGGAGTTATTTGG
CCAGGGCCTTTTGAACAGTAGTGTCCCCATGAAGTGCTAGATAATATATGTGTAAGAGTCAGCTTTTTTTTTTTTTTTAACTCTAACACC

>80311_80311_1_SEMA4B-GLUD1_SEMA4B_chr15_90744967_ENST00000332496_GLUD1_chr10_88827914_ENST00000277865_length(amino acids)=442AA_BP=97
MTLTHSRSGGGGPRGDSGADRGAELPPVSPAEPPEPEPRDTVAPALRMLRTAMGLRSWLAAPWGALPPRPPLLLLLLLLLLLQPPPPTWA
LSPRISLPLGPGIDVPAPDMSTGEREMSWIADTYASTIGHYDINAHACVTGKPISQGGIHGRISATGRGVFHGIENFINEASYMSILGMT
PGFGDKTFVVQGFGNVGLHSMRYLHRFGAKCIAVGESDGSIWNPDGIDPKELEDFKLQHGSILGFPKAKPYEGSILEADCDILIPAASEK
QLTKSNAPRVKAKIIAEGANGPTTPEADKIFLERNIMVIPDLYLNAGGVTVSYFEWLKNLNHVSYGRLTFKYERDSNYHLLMSVQESLER

--------------------------------------------------------------
>80311_80311_2_SEMA4B-GLUD1_SEMA4B_chr15_90744967_ENST00000332496_GLUD1_chr10_88827914_ENST00000537649_length(transcript)=2689nt_BP=397nt
CTCCGGGTCCCCAGGGGCTGCGCCGGGCCGGCCTGGCAAGGGGGACGAGTCAGTGGACACTCCAGGAAGAGCGGCCCCGCGGGGGGCGAT
GACCGTGCGCTGACCCTGACTCACTCCAGGTCCGGAGGCGGGGGCCCCCGGGGCGACTCGGGGGCGGACCGCGGGGCGGAGCTGCCGCCC
GTGAGTCCGGCCGAGCCACCTGAGCCCGAGCCGCGGGACACCGTCGCTCCTGCTCTCCGAATGCTGCGCACCGCGATGGGCCTGAGGAGC
TGGCTCGCCGCCCCATGGGGCGCGCTGCCGCCTCGGCCACCGCTGCTGCTGCTCCTGCTGCTGCTGCTCCTGCTGCAGCCGCCGCCTCCG
ACCTGGGCGCTCAGCCCCCGGATCAGCCTGCCTCTGGGTCCTGGCATTGATGTGCCTGCTCCAGACATGAGCACAGGTGAGCGGGAGATG
TCCTGGATCGCTGATACCTATGCCAGCACCATAGGGCACTATGATATTAATGCACACGCCTGTGTTACTGGTAAACCCATCAGCCAAGGG
GGAATCCATGGACGCATCTCTGCTACTGGCCGTGGTGTCTTCCATGGGATTGAAAATTTCATCAATGAAGCTTCTTACATGAGCATTTTA
GGAATGACACCAGGGTTTGGAGATAAAACATTTGTTGTTCAGGGATTTGGTAATGTGGGCCTACACTCTATGAGATATTTACATCGTTTT
GGTGCTAAATGTATTGCTGTTGGTGAGTCTGATGGGAGTATATGGAATCCAGATGGTATTGACCCAAAGGAACTGGAAGACTTCAAATTG
CAACATGGGTCCATTCTGGGCTTCCCCAAGGCAAAGCCCTATGAAGGAAGCATCTTGGAGGCCGACTGTGACATACTGATCCCAGCTGCC
AGTGAGAAGCAGTTGACCAAATCCAACGCACCCAGAGTCAAAGCCAAGATCATTGCTGAAGGTGCCAATGGGCCAACAACTCCAGAAGCT
GACAAGATCTTCCTGGAGAGAAACATTATGGTTATTCCAGATCTCTACTTGAATGCTGGAGGAGTGACAGTATCTTACTTTGAGTGGCTG
AAGAATCTAAATCATGTCAGCTATGGCCGTTTGACCTTCAAATATGAAAGGGATTCTAACTACCACTTGCTCATGTCTGTTCAAGAGAGT
TTAGAAAGAAAATTTGGAAAGCATGGTGGAACTATTCCCATTGTACCCACGGCAGAGTTCCAAGACAGGATATCGGGTGCATCTGAGAAA
GACATCGTGCACTCTGGCTTGGCATACACAATGGAGCGTTCTGCCAGGCAAATTATGCGCACAGCCATGAAGTATAACCTGGGATTGGAC
CTGAGAACAGCTGCCTATGTTAATGCCATTGAGAAAGTCTTCAAAGTGTACAATGAAGCTGGTGTGACCTTCACATAGATGGATCATGGC
TGACTTCCTCACTATCCTCTTCACATGTAACTTCTGCAGACCTATCACAAGTTTACATGTAACCACAGAAATCCCTTTCTCTCCTGACTC
ATTAATAATGGATACCATTCTCAACAAGTCAATCCAAGTCAGCCCGTTAAGGAGAAAGAAATTAAGGTTAGCGGATCATGTACAAGCTGA
GTGTGAAAGTAGAAATCACCTACACCAGAGAGCCATTTTGGTATTTTGCCTTTAAATAAAAAGCCTCCTTTATCTGGCTGTGCAGCCTTG
CTCTGTGGCTTTTCCCAACACAATCAGTGCTAGTGCTGGGGAGGAACAGTCAAGAGCAGTCAGTTGCTTGCTTATTTTTTCTGGATGAGT
CTGGGACACACTGTAACTTTAACACATTTAAGAAGTAGGTGTGTGGCCTTTTCAGAAGGTGGCATGGTCCTCAAGTGAGTTCTTAGTATT
TTATATCAGCAAAATAATTCAATTTTGCAGGTTGCAAACAAATATAAAACCTGTTTCTGTTTATGAATATTATTCTTTTAGAATAGAATA
AGTACATGCTGCTGTAATAAAATTGCCTTTAATCACTTAACAAGCCTAACCTTGACTCAAACAGTGAATGCCTATAGAAATAATAAATGA
AAAAAACTAGTATTTTTATATCATAAAACAATGTCATTTATAGCTTATCATTCATGTATTGTCCAGCAGACATTAAAAGCCCTGTGGATA
ATTAAGTTATCTTCATACCTGCAAAATGGTGGAGGCTATTTTCATTAAAACTGTCAGAATTTGCTTACTATAATTATGATACAGTCCAAA
GAATGCAGTCACTTTTTATCATGTTAACTAATTGTTCTCTTTTGAAGATCTATGGTTGACTAATTAAACAATAATTCAAGTAGAGTGTCC
CAGAAAAAAACCACTTGGGCTCCCTGTTTGGAGTCTGGCTGGCTCTGAGCATTGCCAATGGCCCCTACTCACCTGACTTTGTATCCTCTC
CTTTTAGAGGCTTTGCATTCTGCACCCAGCTTCACTAACAGTGGGCTGAAAACATCCTTGGGTTGAGTGTTTCATTTGGGAGTTATTTGG
CCAGGGCCTTTTGAACAGTAGTGTCCCCATGAAGTGCTAGATAATATATGTGTAAGAGTCAGCTTTTTTTTTTTTTTTAACTCTAACACC

>80311_80311_2_SEMA4B-GLUD1_SEMA4B_chr15_90744967_ENST00000332496_GLUD1_chr10_88827914_ENST00000537649_length(amino acids)=442AA_BP=97
MTLTHSRSGGGGPRGDSGADRGAELPPVSPAEPPEPEPRDTVAPALRMLRTAMGLRSWLAAPWGALPPRPPLLLLLLLLLLLQPPPPTWA
LSPRISLPLGPGIDVPAPDMSTGEREMSWIADTYASTIGHYDINAHACVTGKPISQGGIHGRISATGRGVFHGIENFINEASYMSILGMT
PGFGDKTFVVQGFGNVGLHSMRYLHRFGAKCIAVGESDGSIWNPDGIDPKELEDFKLQHGSILGFPKAKPYEGSILEADCDILIPAASEK
QLTKSNAPRVKAKIIAEGANGPTTPEADKIFLERNIMVIPDLYLNAGGVTVSYFEWLKNLNHVSYGRLTFKYERDSNYHLLMSVQESLER

--------------------------------------------------------------
>80311_80311_3_SEMA4B-GLUD1_SEMA4B_chr15_90744967_ENST00000332496_GLUD1_chr10_88827914_ENST00000544149_length(transcript)=1578nt_BP=397nt
CTCCGGGTCCCCAGGGGCTGCGCCGGGCCGGCCTGGCAAGGGGGACGAGTCAGTGGACACTCCAGGAAGAGCGGCCCCGCGGGGGGCGAT
GACCGTGCGCTGACCCTGACTCACTCCAGGTCCGGAGGCGGGGGCCCCCGGGGCGACTCGGGGGCGGACCGCGGGGCGGAGCTGCCGCCC
GTGAGTCCGGCCGAGCCACCTGAGCCCGAGCCGCGGGACACCGTCGCTCCTGCTCTCCGAATGCTGCGCACCGCGATGGGCCTGAGGAGC
TGGCTCGCCGCCCCATGGGGCGCGCTGCCGCCTCGGCCACCGCTGCTGCTGCTCCTGCTGCTGCTGCTCCTGCTGCAGCCGCCGCCTCCG
ACCTGGGCGCTCAGCCCCCGGATCAGCCTGCCTCTGGGTCCTGGCATTGATGTGCCTGCTCCAGACATGAGCACAGGTGAGCGGGAGATG
TCCTGGATCGCTGATACCTATGCCAGCACCATAGGGCACTATGATATTAATGCACACGCCTGTGTTACTGGTAAACCCATCAGCCAAGGG
GGAATCCATGGACGCATCTCTGCTACTGGCCGTGGTGTCTTCCATGGGATTGAAAATTTCATCAATGAAGCTTCTTACATGAGCATTTTA
GGAATGACACCAGGGTTTGGAGATAAAACATTTGTTGTTCAGGGATTTGGTAATGTGGGCCTACACTCTATGAGATATTTACATCGTTTT
GGTGCTAAATGTATTGCTGTTGGTGAGTCTGATGGGAGTATATGGAATCCAGATGGTATTGACCCAAAGGAACTGGAAGACTTCAAATTG
CAACATGGGTCCATTCTGGGCTTCCCCAAGGCAAAGCCCTATGAAGGAAGCATCTTGGAGGCCGACTGTGACATACTGATCCCAGCTGCC
AGTGAGAAGCAGTTGACCAAATCCAACGCACCCAGAGTCAAAGCCAAGATCATTGCTGAAGGTGCCAATGGGCCAACAACTCCAGAAGCT
GACAAGATCTTCCTGGAGAGAAACATTATGGTTATTCCAGATCTCTACTTGAATGCTGGAGGAGTGACAGTATCTTACTTTGAGTGGCTG
AAGAATCTAAATCATGTCAGCTATGGCCGTTTGACCTTCAAATATGAAAGGGATTCTAACTACCACTTGCTCATGTCTGTTCAAGAGAGT
TTAGAAAGAAAATTTGGAAAGCATGGTGGAACTATTCCCATTGTACCCACGGCAGAGTTCCAAGACAGGATATCGGGTGCATCTGAGAAA
GACATCGTGCACTCTGGCTTGGCATACACAATGGAGCGTTCTGCCAGGCAAATTATGCGCACAGCCATGAAGTATAACCTGGGATTGGAC
CTGAGAACAGCTGCCTATGTTAATGCCATTGAGAAAGTCTTCAAAGTGTACAATGAAGCTGGTGTGACCTTCACATAGATGGATCATGGC
TGACTTCCTCACTATCCTCTTCACATGTAACTTCTGCAGACCTATCACAAGTTTACATGTAACCACAGAAATCCCTTTCTCTCCTGACTC

>80311_80311_3_SEMA4B-GLUD1_SEMA4B_chr15_90744967_ENST00000332496_GLUD1_chr10_88827914_ENST00000544149_length(amino acids)=442AA_BP=97
MTLTHSRSGGGGPRGDSGADRGAELPPVSPAEPPEPEPRDTVAPALRMLRTAMGLRSWLAAPWGALPPRPPLLLLLLLLLLLQPPPPTWA
LSPRISLPLGPGIDVPAPDMSTGEREMSWIADTYASTIGHYDINAHACVTGKPISQGGIHGRISATGRGVFHGIENFINEASYMSILGMT
PGFGDKTFVVQGFGNVGLHSMRYLHRFGAKCIAVGESDGSIWNPDGIDPKELEDFKLQHGSILGFPKAKPYEGSILEADCDILIPAASEK
QLTKSNAPRVKAKIIAEGANGPTTPEADKIFLERNIMVIPDLYLNAGGVTVSYFEWLKNLNHVSYGRLTFKYERDSNYHLLMSVQESLER

--------------------------------------------------------------
>80311_80311_4_SEMA4B-GLUD1_SEMA4B_chr15_90744967_ENST00000379122_GLUD1_chr10_88827914_ENST00000277865_length(transcript)=2736nt_BP=440nt
ATTTCCGGGGACGCCGCGCCGGACTGAGGCTGTGCGCCCGAGACTCCGGGTCCCCAGGGGCTGCGCCGGGCCGGCCTGGCAAGGGGGACG
AGTCAGTGGACACTCCAGGAAGAGCGGCCCCGCGGGGGGCGATGACCGTGCGCTGACCCTGACTCACTCCAGGTCCGGAGGCGGGGGCCC
CCGGGGCGACTCGGGGGCGGACCGCGGGGCGGAGCTGCCGCCCGTGAGTCCGGCCGAGCCACCTGAGCCCGAGCCGCGGGACACCGTCGC
TCCTGCTCTCCGAATGCTGCGCACCGCGATGGGCCTGAGGAGCTGGCTCGCCGCCCCATGGGGCGCGCTGCCGCCTCGGCCACCGCTGCT
GCTGCTCCTGCTGCTGCTGCTCCTGCTGCAGCCGCCGCCTCCGACCTGGGCGCTCAGCCCCCGGATCAGCCTGCCTCTGGGTCCTGGCAT
TGATGTGCCTGCTCCAGACATGAGCACAGGTGAGCGGGAGATGTCCTGGATCGCTGATACCTATGCCAGCACCATAGGGCACTATGATAT
TAATGCACACGCCTGTGTTACTGGTAAACCCATCAGCCAAGGGGGAATCCATGGACGCATCTCTGCTACTGGCCGTGGTGTCTTCCATGG
GATTGAAAATTTCATCAATGAAGCTTCTTACATGAGCATTTTAGGAATGACACCAGGGTTTGGAGATAAAACATTTGTTGTTCAGGGATT
TGGTAATGTGGGCCTACACTCTATGAGATATTTACATCGTTTTGGTGCTAAATGTATTGCTGTTGGTGAGTCTGATGGGAGTATATGGAA
TCCAGATGGTATTGACCCAAAGGAACTGGAAGACTTCAAATTGCAACATGGGTCCATTCTGGGCTTCCCCAAGGCAAAGCCCTATGAAGG
AAGCATCTTGGAGGCCGACTGTGACATACTGATCCCAGCTGCCAGTGAGAAGCAGTTGACCAAATCCAACGCACCCAGAGTCAAAGCCAA
GATCATTGCTGAAGGTGCCAATGGGCCAACAACTCCAGAAGCTGACAAGATCTTCCTGGAGAGAAACATTATGGTTATTCCAGATCTCTA
CTTGAATGCTGGAGGAGTGACAGTATCTTACTTTGAGTGGCTGAAGAATCTAAATCATGTCAGCTATGGCCGTTTGACCTTCAAATATGA
AAGGGATTCTAACTACCACTTGCTCATGTCTGTTCAAGAGAGTTTAGAAAGAAAATTTGGAAAGCATGGTGGAACTATTCCCATTGTACC
CACGGCAGAGTTCCAAGACAGGATATCGGGTGCATCTGAGAAAGACATCGTGCACTCTGGCTTGGCATACACAATGGAGCGTTCTGCCAG
GCAAATTATGCGCACAGCCATGAAGTATAACCTGGGATTGGACCTGAGAACAGCTGCCTATGTTAATGCCATTGAGAAAGTCTTCAAAGT
GTACAATGAAGCTGGTGTGACCTTCACATAGATGGATCATGGCTGACTTCCTCACTATCCTCTTCACATGTAACTTCTGCAGACCTATCA
CAAGTTTACATGTAACCACAGAAATCCCTTTCTCTCCTGACTCATTAATAATGGATACCATTCTCAACAAGTCAATCCAAGTCAGCCCGT
TAAGGAGAAAGAAATTAAGGTTAGCGGATCATGTACAAGCTGAGTGTGAAAGTAGAAATCACCTACACCAGAGAGCCATTTTGGTATTTT
GCCTTTAAATAAAAAGCCTCCTTTATCTGGCTGTGCAGCCTTGCTCTGTGGCTTTTCCCAACACAATCAGTGCTAGTGCTGGGGAGGAAC
AGTCAAGAGCAGTCAGTTGCTTGCTTATTTTTTCTGGATGAGTCTGGGACACACTGTAACTTTAACACATTTAAGAAGTAGGTGTGTGGC
CTTTTCAGAAGGTGGCATGGTCCTCAAGTGAGTTCTTAGTATTTTATATCAGCAAAATAATTCAATTTTGCAGGTTGCAAACAAATATAA
AACCTGTTTCTGTTTATGAATATTATTCTTTTAGAATAGAATAAGTACATGCTGCTGTAATAAAATTGCCTTTAATCACTTAACAAGCCT
AACCTTGACTCAAACAGTGAATGCCTATAGAAATAATAAATGAAAAAAACTAGTATTTTTATATCATAAAACAATGTCATTTATAGCTTA
TCATTCATGTATTGTCCAGCAGACATTAAAAGCCCTGTGGATAATTAAGTTATCTTCATACCTGCAAAATGGTGGAGGCTATTTTCATTA
AAACTGTCAGAATTTGCTTACTATAATTATGATACAGTCCAAAGAATGCAGTCACTTTTTATCATGTTAACTAATTGTTCTCTTTTGAAG
ATCTATGGTTGACTAATTAAACAATAATTCAAGTAGAGTGTCCCAGAAAAAAACCACTTGGGCTCCCTGTTTGGAGTCTGGCTGGCTCTG
AGCATTGCCAATGGCCCCTACTCACCTGACTTTGTATCCTCTCCTTTTAGAGGCTTTGCATTCTGCACCCAGCTTCACTAACAGTGGGCT
GAAAACATCCTTGGGTTGAGTGTTTCATTTGGGAGTTATTTGGCCAGGGCCTTTTGAACAGTAGTGTCCCCATGAAGTGCTAGATAATAT
ATGTGTAAGAGTCAGCTTTTTTTTTTTTTTTAACTCTAACACCCTTCAGAAATTTCTAACTACTTTGTAACTGCATGGCTTAACCTGGTG

>80311_80311_4_SEMA4B-GLUD1_SEMA4B_chr15_90744967_ENST00000379122_GLUD1_chr10_88827914_ENST00000277865_length(amino acids)=442AA_BP=97
MTLTHSRSGGGGPRGDSGADRGAELPPVSPAEPPEPEPRDTVAPALRMLRTAMGLRSWLAAPWGALPPRPPLLLLLLLLLLLQPPPPTWA
LSPRISLPLGPGIDVPAPDMSTGEREMSWIADTYASTIGHYDINAHACVTGKPISQGGIHGRISATGRGVFHGIENFINEASYMSILGMT
PGFGDKTFVVQGFGNVGLHSMRYLHRFGAKCIAVGESDGSIWNPDGIDPKELEDFKLQHGSILGFPKAKPYEGSILEADCDILIPAASEK
QLTKSNAPRVKAKIIAEGANGPTTPEADKIFLERNIMVIPDLYLNAGGVTVSYFEWLKNLNHVSYGRLTFKYERDSNYHLLMSVQESLER

--------------------------------------------------------------
>80311_80311_5_SEMA4B-GLUD1_SEMA4B_chr15_90744967_ENST00000379122_GLUD1_chr10_88827914_ENST00000537649_length(transcript)=2732nt_BP=440nt
ATTTCCGGGGACGCCGCGCCGGACTGAGGCTGTGCGCCCGAGACTCCGGGTCCCCAGGGGCTGCGCCGGGCCGGCCTGGCAAGGGGGACG
AGTCAGTGGACACTCCAGGAAGAGCGGCCCCGCGGGGGGCGATGACCGTGCGCTGACCCTGACTCACTCCAGGTCCGGAGGCGGGGGCCC
CCGGGGCGACTCGGGGGCGGACCGCGGGGCGGAGCTGCCGCCCGTGAGTCCGGCCGAGCCACCTGAGCCCGAGCCGCGGGACACCGTCGC
TCCTGCTCTCCGAATGCTGCGCACCGCGATGGGCCTGAGGAGCTGGCTCGCCGCCCCATGGGGCGCGCTGCCGCCTCGGCCACCGCTGCT
GCTGCTCCTGCTGCTGCTGCTCCTGCTGCAGCCGCCGCCTCCGACCTGGGCGCTCAGCCCCCGGATCAGCCTGCCTCTGGGTCCTGGCAT
TGATGTGCCTGCTCCAGACATGAGCACAGGTGAGCGGGAGATGTCCTGGATCGCTGATACCTATGCCAGCACCATAGGGCACTATGATAT
TAATGCACACGCCTGTGTTACTGGTAAACCCATCAGCCAAGGGGGAATCCATGGACGCATCTCTGCTACTGGCCGTGGTGTCTTCCATGG
GATTGAAAATTTCATCAATGAAGCTTCTTACATGAGCATTTTAGGAATGACACCAGGGTTTGGAGATAAAACATTTGTTGTTCAGGGATT
TGGTAATGTGGGCCTACACTCTATGAGATATTTACATCGTTTTGGTGCTAAATGTATTGCTGTTGGTGAGTCTGATGGGAGTATATGGAA
TCCAGATGGTATTGACCCAAAGGAACTGGAAGACTTCAAATTGCAACATGGGTCCATTCTGGGCTTCCCCAAGGCAAAGCCCTATGAAGG
AAGCATCTTGGAGGCCGACTGTGACATACTGATCCCAGCTGCCAGTGAGAAGCAGTTGACCAAATCCAACGCACCCAGAGTCAAAGCCAA
GATCATTGCTGAAGGTGCCAATGGGCCAACAACTCCAGAAGCTGACAAGATCTTCCTGGAGAGAAACATTATGGTTATTCCAGATCTCTA
CTTGAATGCTGGAGGAGTGACAGTATCTTACTTTGAGTGGCTGAAGAATCTAAATCATGTCAGCTATGGCCGTTTGACCTTCAAATATGA
AAGGGATTCTAACTACCACTTGCTCATGTCTGTTCAAGAGAGTTTAGAAAGAAAATTTGGAAAGCATGGTGGAACTATTCCCATTGTACC
CACGGCAGAGTTCCAAGACAGGATATCGGGTGCATCTGAGAAAGACATCGTGCACTCTGGCTTGGCATACACAATGGAGCGTTCTGCCAG
GCAAATTATGCGCACAGCCATGAAGTATAACCTGGGATTGGACCTGAGAACAGCTGCCTATGTTAATGCCATTGAGAAAGTCTTCAAAGT
GTACAATGAAGCTGGTGTGACCTTCACATAGATGGATCATGGCTGACTTCCTCACTATCCTCTTCACATGTAACTTCTGCAGACCTATCA
CAAGTTTACATGTAACCACAGAAATCCCTTTCTCTCCTGACTCATTAATAATGGATACCATTCTCAACAAGTCAATCCAAGTCAGCCCGT
TAAGGAGAAAGAAATTAAGGTTAGCGGATCATGTACAAGCTGAGTGTGAAAGTAGAAATCACCTACACCAGAGAGCCATTTTGGTATTTT
GCCTTTAAATAAAAAGCCTCCTTTATCTGGCTGTGCAGCCTTGCTCTGTGGCTTTTCCCAACACAATCAGTGCTAGTGCTGGGGAGGAAC
AGTCAAGAGCAGTCAGTTGCTTGCTTATTTTTTCTGGATGAGTCTGGGACACACTGTAACTTTAACACATTTAAGAAGTAGGTGTGTGGC
CTTTTCAGAAGGTGGCATGGTCCTCAAGTGAGTTCTTAGTATTTTATATCAGCAAAATAATTCAATTTTGCAGGTTGCAAACAAATATAA
AACCTGTTTCTGTTTATGAATATTATTCTTTTAGAATAGAATAAGTACATGCTGCTGTAATAAAATTGCCTTTAATCACTTAACAAGCCT
AACCTTGACTCAAACAGTGAATGCCTATAGAAATAATAAATGAAAAAAACTAGTATTTTTATATCATAAAACAATGTCATTTATAGCTTA
TCATTCATGTATTGTCCAGCAGACATTAAAAGCCCTGTGGATAATTAAGTTATCTTCATACCTGCAAAATGGTGGAGGCTATTTTCATTA
AAACTGTCAGAATTTGCTTACTATAATTATGATACAGTCCAAAGAATGCAGTCACTTTTTATCATGTTAACTAATTGTTCTCTTTTGAAG
ATCTATGGTTGACTAATTAAACAATAATTCAAGTAGAGTGTCCCAGAAAAAAACCACTTGGGCTCCCTGTTTGGAGTCTGGCTGGCTCTG
AGCATTGCCAATGGCCCCTACTCACCTGACTTTGTATCCTCTCCTTTTAGAGGCTTTGCATTCTGCACCCAGCTTCACTAACAGTGGGCT
GAAAACATCCTTGGGTTGAGTGTTTCATTTGGGAGTTATTTGGCCAGGGCCTTTTGAACAGTAGTGTCCCCATGAAGTGCTAGATAATAT
ATGTGTAAGAGTCAGCTTTTTTTTTTTTTTTAACTCTAACACCCTTCAGAAATTTCTAACTACTTTGTAACTGCATGGCTTAACCTGGTG

>80311_80311_5_SEMA4B-GLUD1_SEMA4B_chr15_90744967_ENST00000379122_GLUD1_chr10_88827914_ENST00000537649_length(amino acids)=442AA_BP=97
MTLTHSRSGGGGPRGDSGADRGAELPPVSPAEPPEPEPRDTVAPALRMLRTAMGLRSWLAAPWGALPPRPPLLLLLLLLLLLQPPPPTWA
LSPRISLPLGPGIDVPAPDMSTGEREMSWIADTYASTIGHYDINAHACVTGKPISQGGIHGRISATGRGVFHGIENFINEASYMSILGMT
PGFGDKTFVVQGFGNVGLHSMRYLHRFGAKCIAVGESDGSIWNPDGIDPKELEDFKLQHGSILGFPKAKPYEGSILEADCDILIPAASEK
QLTKSNAPRVKAKIIAEGANGPTTPEADKIFLERNIMVIPDLYLNAGGVTVSYFEWLKNLNHVSYGRLTFKYERDSNYHLLMSVQESLER

--------------------------------------------------------------
>80311_80311_6_SEMA4B-GLUD1_SEMA4B_chr15_90744967_ENST00000379122_GLUD1_chr10_88827914_ENST00000544149_length(transcript)=1621nt_BP=440nt
ATTTCCGGGGACGCCGCGCCGGACTGAGGCTGTGCGCCCGAGACTCCGGGTCCCCAGGGGCTGCGCCGGGCCGGCCTGGCAAGGGGGACG
AGTCAGTGGACACTCCAGGAAGAGCGGCCCCGCGGGGGGCGATGACCGTGCGCTGACCCTGACTCACTCCAGGTCCGGAGGCGGGGGCCC
CCGGGGCGACTCGGGGGCGGACCGCGGGGCGGAGCTGCCGCCCGTGAGTCCGGCCGAGCCACCTGAGCCCGAGCCGCGGGACACCGTCGC
TCCTGCTCTCCGAATGCTGCGCACCGCGATGGGCCTGAGGAGCTGGCTCGCCGCCCCATGGGGCGCGCTGCCGCCTCGGCCACCGCTGCT
GCTGCTCCTGCTGCTGCTGCTCCTGCTGCAGCCGCCGCCTCCGACCTGGGCGCTCAGCCCCCGGATCAGCCTGCCTCTGGGTCCTGGCAT
TGATGTGCCTGCTCCAGACATGAGCACAGGTGAGCGGGAGATGTCCTGGATCGCTGATACCTATGCCAGCACCATAGGGCACTATGATAT
TAATGCACACGCCTGTGTTACTGGTAAACCCATCAGCCAAGGGGGAATCCATGGACGCATCTCTGCTACTGGCCGTGGTGTCTTCCATGG
GATTGAAAATTTCATCAATGAAGCTTCTTACATGAGCATTTTAGGAATGACACCAGGGTTTGGAGATAAAACATTTGTTGTTCAGGGATT
TGGTAATGTGGGCCTACACTCTATGAGATATTTACATCGTTTTGGTGCTAAATGTATTGCTGTTGGTGAGTCTGATGGGAGTATATGGAA
TCCAGATGGTATTGACCCAAAGGAACTGGAAGACTTCAAATTGCAACATGGGTCCATTCTGGGCTTCCCCAAGGCAAAGCCCTATGAAGG
AAGCATCTTGGAGGCCGACTGTGACATACTGATCCCAGCTGCCAGTGAGAAGCAGTTGACCAAATCCAACGCACCCAGAGTCAAAGCCAA
GATCATTGCTGAAGGTGCCAATGGGCCAACAACTCCAGAAGCTGACAAGATCTTCCTGGAGAGAAACATTATGGTTATTCCAGATCTCTA
CTTGAATGCTGGAGGAGTGACAGTATCTTACTTTGAGTGGCTGAAGAATCTAAATCATGTCAGCTATGGCCGTTTGACCTTCAAATATGA
AAGGGATTCTAACTACCACTTGCTCATGTCTGTTCAAGAGAGTTTAGAAAGAAAATTTGGAAAGCATGGTGGAACTATTCCCATTGTACC
CACGGCAGAGTTCCAAGACAGGATATCGGGTGCATCTGAGAAAGACATCGTGCACTCTGGCTTGGCATACACAATGGAGCGTTCTGCCAG
GCAAATTATGCGCACAGCCATGAAGTATAACCTGGGATTGGACCTGAGAACAGCTGCCTATGTTAATGCCATTGAGAAAGTCTTCAAAGT
GTACAATGAAGCTGGTGTGACCTTCACATAGATGGATCATGGCTGACTTCCTCACTATCCTCTTCACATGTAACTTCTGCAGACCTATCA
CAAGTTTACATGTAACCACAGAAATCCCTTTCTCTCCTGACTCATTAATAATGGATACCATTCTCAACAAGTCAATCCAAGTCAGCCCGT

>80311_80311_6_SEMA4B-GLUD1_SEMA4B_chr15_90744967_ENST00000379122_GLUD1_chr10_88827914_ENST00000544149_length(amino acids)=442AA_BP=97
MTLTHSRSGGGGPRGDSGADRGAELPPVSPAEPPEPEPRDTVAPALRMLRTAMGLRSWLAAPWGALPPRPPLLLLLLLLLLLQPPPPTWA
LSPRISLPLGPGIDVPAPDMSTGEREMSWIADTYASTIGHYDINAHACVTGKPISQGGIHGRISATGRGVFHGIENFINEASYMSILGMT
PGFGDKTFVVQGFGNVGLHSMRYLHRFGAKCIAVGESDGSIWNPDGIDPKELEDFKLQHGSILGFPKAKPYEGSILEADCDILIPAASEK
QLTKSNAPRVKAKIIAEGANGPTTPEADKIFLERNIMVIPDLYLNAGGVTVSYFEWLKNLNHVSYGRLTFKYERDSNYHLLMSVQESLER

--------------------------------------------------------------
>80311_80311_7_SEMA4B-GLUD1_SEMA4B_chr15_90744967_ENST00000411539_GLUD1_chr10_88827914_ENST00000277865_length(transcript)=2713nt_BP=417nt
CGCCCTCCGCCGCTTGCGGGTGAGCTCTGCCCAAGCCGAGGCTGCGGGGCCGGCGCCGGCGGGAGGACTGCGGTGCCCCGCGGAGGGGCT
GAGTTTGCCAGGGCCCACTTGACCCTGTTTCCCACCTCCCGCCCCCCAGGTCCGGAGGCGGGGGCCCCCGGGGCGACTCGGGGGCGGACC
GCGGGGCGGAGCTGCCGCCCGTGAGTCCGGCCGAGCCACCTGAGCCCGAGCCGCGGGACACCGTCGCTCCTGCTCTCCGAATGCTGCGCA
CCGCGATGGGCCTGAGGAGCTGGCTCGCCGCCCCATGGGGCGCGCTGCCGCCTCGGCCACCGCTGCTGCTGCTCCTGCTGCTGCTGCTCC
TGCTGCAGCCGCCGCCTCCGACCTGGGCGCTCAGCCCCCGGATCAGCCTGCCTCTGGGTCCTGGCATTGATGTGCCTGCTCCAGACATGA
GCACAGGTGAGCGGGAGATGTCCTGGATCGCTGATACCTATGCCAGCACCATAGGGCACTATGATATTAATGCACACGCCTGTGTTACTG
GTAAACCCATCAGCCAAGGGGGAATCCATGGACGCATCTCTGCTACTGGCCGTGGTGTCTTCCATGGGATTGAAAATTTCATCAATGAAG
CTTCTTACATGAGCATTTTAGGAATGACACCAGGGTTTGGAGATAAAACATTTGTTGTTCAGGGATTTGGTAATGTGGGCCTACACTCTA
TGAGATATTTACATCGTTTTGGTGCTAAATGTATTGCTGTTGGTGAGTCTGATGGGAGTATATGGAATCCAGATGGTATTGACCCAAAGG
AACTGGAAGACTTCAAATTGCAACATGGGTCCATTCTGGGCTTCCCCAAGGCAAAGCCCTATGAAGGAAGCATCTTGGAGGCCGACTGTG
ACATACTGATCCCAGCTGCCAGTGAGAAGCAGTTGACCAAATCCAACGCACCCAGAGTCAAAGCCAAGATCATTGCTGAAGGTGCCAATG
GGCCAACAACTCCAGAAGCTGACAAGATCTTCCTGGAGAGAAACATTATGGTTATTCCAGATCTCTACTTGAATGCTGGAGGAGTGACAG
TATCTTACTTTGAGTGGCTGAAGAATCTAAATCATGTCAGCTATGGCCGTTTGACCTTCAAATATGAAAGGGATTCTAACTACCACTTGC
TCATGTCTGTTCAAGAGAGTTTAGAAAGAAAATTTGGAAAGCATGGTGGAACTATTCCCATTGTACCCACGGCAGAGTTCCAAGACAGGA
TATCGGGTGCATCTGAGAAAGACATCGTGCACTCTGGCTTGGCATACACAATGGAGCGTTCTGCCAGGCAAATTATGCGCACAGCCATGA
AGTATAACCTGGGATTGGACCTGAGAACAGCTGCCTATGTTAATGCCATTGAGAAAGTCTTCAAAGTGTACAATGAAGCTGGTGTGACCT
TCACATAGATGGATCATGGCTGACTTCCTCACTATCCTCTTCACATGTAACTTCTGCAGACCTATCACAAGTTTACATGTAACCACAGAA
ATCCCTTTCTCTCCTGACTCATTAATAATGGATACCATTCTCAACAAGTCAATCCAAGTCAGCCCGTTAAGGAGAAAGAAATTAAGGTTA
GCGGATCATGTACAAGCTGAGTGTGAAAGTAGAAATCACCTACACCAGAGAGCCATTTTGGTATTTTGCCTTTAAATAAAAAGCCTCCTT
TATCTGGCTGTGCAGCCTTGCTCTGTGGCTTTTCCCAACACAATCAGTGCTAGTGCTGGGGAGGAACAGTCAAGAGCAGTCAGTTGCTTG
CTTATTTTTTCTGGATGAGTCTGGGACACACTGTAACTTTAACACATTTAAGAAGTAGGTGTGTGGCCTTTTCAGAAGGTGGCATGGTCC
TCAAGTGAGTTCTTAGTATTTTATATCAGCAAAATAATTCAATTTTGCAGGTTGCAAACAAATATAAAACCTGTTTCTGTTTATGAATAT
TATTCTTTTAGAATAGAATAAGTACATGCTGCTGTAATAAAATTGCCTTTAATCACTTAACAAGCCTAACCTTGACTCAAACAGTGAATG
CCTATAGAAATAATAAATGAAAAAAACTAGTATTTTTATATCATAAAACAATGTCATTTATAGCTTATCATTCATGTATTGTCCAGCAGA
CATTAAAAGCCCTGTGGATAATTAAGTTATCTTCATACCTGCAAAATGGTGGAGGCTATTTTCATTAAAACTGTCAGAATTTGCTTACTA
TAATTATGATACAGTCCAAAGAATGCAGTCACTTTTTATCATGTTAACTAATTGTTCTCTTTTGAAGATCTATGGTTGACTAATTAAACA
ATAATTCAAGTAGAGTGTCCCAGAAAAAAACCACTTGGGCTCCCTGTTTGGAGTCTGGCTGGCTCTGAGCATTGCCAATGGCCCCTACTC
ACCTGACTTTGTATCCTCTCCTTTTAGAGGCTTTGCATTCTGCACCCAGCTTCACTAACAGTGGGCTGAAAACATCCTTGGGTTGAGTGT
TTCATTTGGGAGTTATTTGGCCAGGGCCTTTTGAACAGTAGTGTCCCCATGAAGTGCTAGATAATATATGTGTAAGAGTCAGCTTTTTTT
TTTTTTTTAACTCTAACACCCTTCAGAAATTTCTAACTACTTTGTAACTGCATGGCTTAACCTGGTGATAAAAGCAGTTATTAAAAGTCT

>80311_80311_7_SEMA4B-GLUD1_SEMA4B_chr15_90744967_ENST00000411539_GLUD1_chr10_88827914_ENST00000277865_length(amino acids)=418AA_BP=73
MPPVSPAEPPEPEPRDTVAPALRMLRTAMGLRSWLAAPWGALPPRPPLLLLLLLLLLLQPPPPTWALSPRISLPLGPGIDVPAPDMSTGE
REMSWIADTYASTIGHYDINAHACVTGKPISQGGIHGRISATGRGVFHGIENFINEASYMSILGMTPGFGDKTFVVQGFGNVGLHSMRYL
HRFGAKCIAVGESDGSIWNPDGIDPKELEDFKLQHGSILGFPKAKPYEGSILEADCDILIPAASEKQLTKSNAPRVKAKIIAEGANGPTT
PEADKIFLERNIMVIPDLYLNAGGVTVSYFEWLKNLNHVSYGRLTFKYERDSNYHLLMSVQESLERKFGKHGGTIPIVPTAEFQDRISGA

--------------------------------------------------------------
>80311_80311_8_SEMA4B-GLUD1_SEMA4B_chr15_90744967_ENST00000411539_GLUD1_chr10_88827914_ENST00000537649_length(transcript)=2709nt_BP=417nt
CGCCCTCCGCCGCTTGCGGGTGAGCTCTGCCCAAGCCGAGGCTGCGGGGCCGGCGCCGGCGGGAGGACTGCGGTGCCCCGCGGAGGGGCT
GAGTTTGCCAGGGCCCACTTGACCCTGTTTCCCACCTCCCGCCCCCCAGGTCCGGAGGCGGGGGCCCCCGGGGCGACTCGGGGGCGGACC
GCGGGGCGGAGCTGCCGCCCGTGAGTCCGGCCGAGCCACCTGAGCCCGAGCCGCGGGACACCGTCGCTCCTGCTCTCCGAATGCTGCGCA
CCGCGATGGGCCTGAGGAGCTGGCTCGCCGCCCCATGGGGCGCGCTGCCGCCTCGGCCACCGCTGCTGCTGCTCCTGCTGCTGCTGCTCC
TGCTGCAGCCGCCGCCTCCGACCTGGGCGCTCAGCCCCCGGATCAGCCTGCCTCTGGGTCCTGGCATTGATGTGCCTGCTCCAGACATGA
GCACAGGTGAGCGGGAGATGTCCTGGATCGCTGATACCTATGCCAGCACCATAGGGCACTATGATATTAATGCACACGCCTGTGTTACTG
GTAAACCCATCAGCCAAGGGGGAATCCATGGACGCATCTCTGCTACTGGCCGTGGTGTCTTCCATGGGATTGAAAATTTCATCAATGAAG
CTTCTTACATGAGCATTTTAGGAATGACACCAGGGTTTGGAGATAAAACATTTGTTGTTCAGGGATTTGGTAATGTGGGCCTACACTCTA
TGAGATATTTACATCGTTTTGGTGCTAAATGTATTGCTGTTGGTGAGTCTGATGGGAGTATATGGAATCCAGATGGTATTGACCCAAAGG
AACTGGAAGACTTCAAATTGCAACATGGGTCCATTCTGGGCTTCCCCAAGGCAAAGCCCTATGAAGGAAGCATCTTGGAGGCCGACTGTG
ACATACTGATCCCAGCTGCCAGTGAGAAGCAGTTGACCAAATCCAACGCACCCAGAGTCAAAGCCAAGATCATTGCTGAAGGTGCCAATG
GGCCAACAACTCCAGAAGCTGACAAGATCTTCCTGGAGAGAAACATTATGGTTATTCCAGATCTCTACTTGAATGCTGGAGGAGTGACAG
TATCTTACTTTGAGTGGCTGAAGAATCTAAATCATGTCAGCTATGGCCGTTTGACCTTCAAATATGAAAGGGATTCTAACTACCACTTGC
TCATGTCTGTTCAAGAGAGTTTAGAAAGAAAATTTGGAAAGCATGGTGGAACTATTCCCATTGTACCCACGGCAGAGTTCCAAGACAGGA
TATCGGGTGCATCTGAGAAAGACATCGTGCACTCTGGCTTGGCATACACAATGGAGCGTTCTGCCAGGCAAATTATGCGCACAGCCATGA
AGTATAACCTGGGATTGGACCTGAGAACAGCTGCCTATGTTAATGCCATTGAGAAAGTCTTCAAAGTGTACAATGAAGCTGGTGTGACCT
TCACATAGATGGATCATGGCTGACTTCCTCACTATCCTCTTCACATGTAACTTCTGCAGACCTATCACAAGTTTACATGTAACCACAGAA
ATCCCTTTCTCTCCTGACTCATTAATAATGGATACCATTCTCAACAAGTCAATCCAAGTCAGCCCGTTAAGGAGAAAGAAATTAAGGTTA
GCGGATCATGTACAAGCTGAGTGTGAAAGTAGAAATCACCTACACCAGAGAGCCATTTTGGTATTTTGCCTTTAAATAAAAAGCCTCCTT
TATCTGGCTGTGCAGCCTTGCTCTGTGGCTTTTCCCAACACAATCAGTGCTAGTGCTGGGGAGGAACAGTCAAGAGCAGTCAGTTGCTTG
CTTATTTTTTCTGGATGAGTCTGGGACACACTGTAACTTTAACACATTTAAGAAGTAGGTGTGTGGCCTTTTCAGAAGGTGGCATGGTCC
TCAAGTGAGTTCTTAGTATTTTATATCAGCAAAATAATTCAATTTTGCAGGTTGCAAACAAATATAAAACCTGTTTCTGTTTATGAATAT
TATTCTTTTAGAATAGAATAAGTACATGCTGCTGTAATAAAATTGCCTTTAATCACTTAACAAGCCTAACCTTGACTCAAACAGTGAATG
CCTATAGAAATAATAAATGAAAAAAACTAGTATTTTTATATCATAAAACAATGTCATTTATAGCTTATCATTCATGTATTGTCCAGCAGA
CATTAAAAGCCCTGTGGATAATTAAGTTATCTTCATACCTGCAAAATGGTGGAGGCTATTTTCATTAAAACTGTCAGAATTTGCTTACTA
TAATTATGATACAGTCCAAAGAATGCAGTCACTTTTTATCATGTTAACTAATTGTTCTCTTTTGAAGATCTATGGTTGACTAATTAAACA
ATAATTCAAGTAGAGTGTCCCAGAAAAAAACCACTTGGGCTCCCTGTTTGGAGTCTGGCTGGCTCTGAGCATTGCCAATGGCCCCTACTC
ACCTGACTTTGTATCCTCTCCTTTTAGAGGCTTTGCATTCTGCACCCAGCTTCACTAACAGTGGGCTGAAAACATCCTTGGGTTGAGTGT
TTCATTTGGGAGTTATTTGGCCAGGGCCTTTTGAACAGTAGTGTCCCCATGAAGTGCTAGATAATATATGTGTAAGAGTCAGCTTTTTTT
TTTTTTTTAACTCTAACACCCTTCAGAAATTTCTAACTACTTTGTAACTGCATGGCTTAACCTGGTGATAAAAGCAGTTATTAAAAGTCT

>80311_80311_8_SEMA4B-GLUD1_SEMA4B_chr15_90744967_ENST00000411539_GLUD1_chr10_88827914_ENST00000537649_length(amino acids)=418AA_BP=73
MPPVSPAEPPEPEPRDTVAPALRMLRTAMGLRSWLAAPWGALPPRPPLLLLLLLLLLLQPPPPTWALSPRISLPLGPGIDVPAPDMSTGE
REMSWIADTYASTIGHYDINAHACVTGKPISQGGIHGRISATGRGVFHGIENFINEASYMSILGMTPGFGDKTFVVQGFGNVGLHSMRYL
HRFGAKCIAVGESDGSIWNPDGIDPKELEDFKLQHGSILGFPKAKPYEGSILEADCDILIPAASEKQLTKSNAPRVKAKIIAEGANGPTT
PEADKIFLERNIMVIPDLYLNAGGVTVSYFEWLKNLNHVSYGRLTFKYERDSNYHLLMSVQESLERKFGKHGGTIPIVPTAEFQDRISGA

--------------------------------------------------------------
>80311_80311_9_SEMA4B-GLUD1_SEMA4B_chr15_90744967_ENST00000411539_GLUD1_chr10_88827914_ENST00000544149_length(transcript)=1598nt_BP=417nt
CGCCCTCCGCCGCTTGCGGGTGAGCTCTGCCCAAGCCGAGGCTGCGGGGCCGGCGCCGGCGGGAGGACTGCGGTGCCCCGCGGAGGGGCT
GAGTTTGCCAGGGCCCACTTGACCCTGTTTCCCACCTCCCGCCCCCCAGGTCCGGAGGCGGGGGCCCCCGGGGCGACTCGGGGGCGGACC
GCGGGGCGGAGCTGCCGCCCGTGAGTCCGGCCGAGCCACCTGAGCCCGAGCCGCGGGACACCGTCGCTCCTGCTCTCCGAATGCTGCGCA
CCGCGATGGGCCTGAGGAGCTGGCTCGCCGCCCCATGGGGCGCGCTGCCGCCTCGGCCACCGCTGCTGCTGCTCCTGCTGCTGCTGCTCC
TGCTGCAGCCGCCGCCTCCGACCTGGGCGCTCAGCCCCCGGATCAGCCTGCCTCTGGGTCCTGGCATTGATGTGCCTGCTCCAGACATGA
GCACAGGTGAGCGGGAGATGTCCTGGATCGCTGATACCTATGCCAGCACCATAGGGCACTATGATATTAATGCACACGCCTGTGTTACTG
GTAAACCCATCAGCCAAGGGGGAATCCATGGACGCATCTCTGCTACTGGCCGTGGTGTCTTCCATGGGATTGAAAATTTCATCAATGAAG
CTTCTTACATGAGCATTTTAGGAATGACACCAGGGTTTGGAGATAAAACATTTGTTGTTCAGGGATTTGGTAATGTGGGCCTACACTCTA
TGAGATATTTACATCGTTTTGGTGCTAAATGTATTGCTGTTGGTGAGTCTGATGGGAGTATATGGAATCCAGATGGTATTGACCCAAAGG
AACTGGAAGACTTCAAATTGCAACATGGGTCCATTCTGGGCTTCCCCAAGGCAAAGCCCTATGAAGGAAGCATCTTGGAGGCCGACTGTG
ACATACTGATCCCAGCTGCCAGTGAGAAGCAGTTGACCAAATCCAACGCACCCAGAGTCAAAGCCAAGATCATTGCTGAAGGTGCCAATG
GGCCAACAACTCCAGAAGCTGACAAGATCTTCCTGGAGAGAAACATTATGGTTATTCCAGATCTCTACTTGAATGCTGGAGGAGTGACAG
TATCTTACTTTGAGTGGCTGAAGAATCTAAATCATGTCAGCTATGGCCGTTTGACCTTCAAATATGAAAGGGATTCTAACTACCACTTGC
TCATGTCTGTTCAAGAGAGTTTAGAAAGAAAATTTGGAAAGCATGGTGGAACTATTCCCATTGTACCCACGGCAGAGTTCCAAGACAGGA
TATCGGGTGCATCTGAGAAAGACATCGTGCACTCTGGCTTGGCATACACAATGGAGCGTTCTGCCAGGCAAATTATGCGCACAGCCATGA
AGTATAACCTGGGATTGGACCTGAGAACAGCTGCCTATGTTAATGCCATTGAGAAAGTCTTCAAAGTGTACAATGAAGCTGGTGTGACCT
TCACATAGATGGATCATGGCTGACTTCCTCACTATCCTCTTCACATGTAACTTCTGCAGACCTATCACAAGTTTACATGTAACCACAGAA

>80311_80311_9_SEMA4B-GLUD1_SEMA4B_chr15_90744967_ENST00000411539_GLUD1_chr10_88827914_ENST00000544149_length(amino acids)=418AA_BP=73
MPPVSPAEPPEPEPRDTVAPALRMLRTAMGLRSWLAAPWGALPPRPPLLLLLLLLLLLQPPPPTWALSPRISLPLGPGIDVPAPDMSTGE
REMSWIADTYASTIGHYDINAHACVTGKPISQGGIHGRISATGRGVFHGIENFINEASYMSILGMTPGFGDKTFVVQGFGNVGLHSMRYL
HRFGAKCIAVGESDGSIWNPDGIDPKELEDFKLQHGSILGFPKAKPYEGSILEADCDILIPAASEKQLTKSNAPRVKAKIIAEGANGPTT
PEADKIFLERNIMVIPDLYLNAGGVTVSYFEWLKNLNHVSYGRLTFKYERDSNYHLLMSVQESLERKFGKHGGTIPIVPTAEFQDRISGA

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Fusion Gene PPI Analysis for SEMA4B-GLUD1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for SEMA4B-GLUD1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for SEMA4B-GLUD1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource