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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:SENP2-ANKRD27 (FusionGDB2 ID:80372)

Fusion Gene Summary for SENP2-ANKRD27

Fusion gene summary

Fusion gene information	Fusion gene name: SENP2-ANKRD27
	Fusion gene ID: 80372
		Hgene	Tgene
	Gene symbol	SENP2	ANKRD27
	Gene ID	59343	84079
	Gene name	SUMO specific peptidase 2	ankyrin repeat domain 27
	Synonyms	AXAM2\|SMT3IP2	PP12899\|VARP
	Cytomap	3q27.2	19q13.11
	Type of gene	protein-coding	protein-coding
	Description	sentrin-specific protease 2SMT3-specific isopeptidase 2SUMO1/sentrin/SMT3 specific peptidase 2SUMO1/sentrin/SMT3 specific protease 2sentrin (SUMO1) specific peptidase 2sentrin/SUMO-specific protease SENP2	ankyrin repeat domain-containing protein 27VPS9 domain-containing proteinVPS9-ankyrin-repeat proteinVps9 domain and ankyrin-repeat-containing proteinankyrin repeat domain 27 (VPS9 domain)
	Modification date	20200313	20200313
	UniProtAcc	.	Q96NW4
	Ensembl transtripts involved in fusion gene	ENST00000427465, ENST00000296257, ENST00000465201, ENST00000545472,	ENST00000306065, ENST00000587352,
Fusion gene scores	* DoF score	13 X 12 X 10=1560	5 X 7 X 3=105
	# samples	16	7
	** MAII score	log2(16/1560*10)=-3.28540221886225 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(7/105*10)=-0.584962500721156 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: SENP2 [Title/Abstract] AND ANKRD27 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	SENP2(185304302)-ANKRD27(33133051), # samples:3
Anticipated loss of major functional domain due to fusion event.	SENP2-ANKRD27 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	SENP2	GO:0016926	protein desumoylation	20194620
Hgene	SENP2	GO:0031397	negative regulation of protein ubiquitination	22028379
Tgene	ANKRD27	GO:0035544	negative regulation of SNARE complex assembly	24856514
Tgene	ANKRD27	GO:0045022	early endosome to late endosome transport	16525121

Fusion gene breakpoints across SENP2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across ANKRD27 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	LUSC	TCGA-21-1071-01A	SENP2	chr3	185304302	-	ANKRD27	chr19	33133051	-
ChimerDB4	LUSC	TCGA-21-1071-01A	SENP2	chr3	185304302	+	ANKRD27	chr19	33133051	-
ChimerDB4	LUSC	TCGA-21-1071	SENP2	chr3	185304302	+	ANKRD27	chr19	33133051	-
ChimerDB4	LUSC	TCGA-21-1071	SENP2	chr3	185304302	+	ANKRD27	chr19	33134105	-

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Fusion Gene ORF analysis for SENP2-ANKRD27

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5UTR-3CDS	ENST00000427465	ENST00000306065	SENP2	chr3	185304302	+	ANKRD27	chr19	33133051	-
5UTR-3CDS	ENST00000427465	ENST00000306065	SENP2	chr3	185304302	+	ANKRD27	chr19	33134105	-
5UTR-3CDS	ENST00000427465	ENST00000587352	SENP2	chr3	185304302	+	ANKRD27	chr19	33133051	-
5UTR-3CDS	ENST00000427465	ENST00000587352	SENP2	chr3	185304302	+	ANKRD27	chr19	33134105	-
Frame-shift	ENST00000296257	ENST00000306065	SENP2	chr3	185304302	+	ANKRD27	chr19	33134105	-
Frame-shift	ENST00000296257	ENST00000587352	SENP2	chr3	185304302	+	ANKRD27	chr19	33134105	-
In-frame	ENST00000296257	ENST00000306065	SENP2	chr3	185304302	+	ANKRD27	chr19	33133051	-
In-frame	ENST00000296257	ENST00000587352	SENP2	chr3	185304302	+	ANKRD27	chr19	33133051	-
intron-3CDS	ENST00000465201	ENST00000306065	SENP2	chr3	185304302	+	ANKRD27	chr19	33133051	-
intron-3CDS	ENST00000465201	ENST00000306065	SENP2	chr3	185304302	+	ANKRD27	chr19	33134105	-
intron-3CDS	ENST00000465201	ENST00000587352	SENP2	chr3	185304302	+	ANKRD27	chr19	33133051	-
intron-3CDS	ENST00000465201	ENST00000587352	SENP2	chr3	185304302	+	ANKRD27	chr19	33134105	-
intron-3CDS	ENST00000545472	ENST00000306065	SENP2	chr3	185304302	+	ANKRD27	chr19	33133051	-
intron-3CDS	ENST00000545472	ENST00000306065	SENP2	chr3	185304302	+	ANKRD27	chr19	33134105	-
intron-3CDS	ENST00000545472	ENST00000587352	SENP2	chr3	185304302	+	ANKRD27	chr19	33133051	-
intron-3CDS	ENST00000545472	ENST00000587352	SENP2	chr3	185304302	+	ANKRD27	chr19	33134105	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000296257

SENP2

chr3

185304302

ENST00000306065

ANKRD27

chr19

33133051

3850

341

2711

900

ENST00000296257

SENP2

chr3

185304302

ENST00000587352

ANKRD27

chr19

33133051

2731

341

728

239

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000296257	ENST00000306065	SENP2	chr3	185304302	+	ANKRD27	chr19	33133051	-	0.001970235	0.99802977
ENST00000296257	ENST00000587352	SENP2	chr3	185304302	+	ANKRD27	chr19	33133051	-	0.24143964	0.75856036

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Fusion Genomic Features for SENP2-ANKRD27

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for SENP2-ANKRD27

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:185304302/chr19:33133051)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	ANKRD27 Q96NW4
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: May be a guanine exchange factor (GEF) for Rab21, Rab32 and Rab38 and regulate endosome dynamics (PubMed:16525121, PubMed:18477474). May regulate the participation of VAMP7 in membrane fusion events; in vitro inhibits VAMP7-mediated SNARE complex formation by trapping VAMP7 in a closed, fusogenically inactive conformation (PubMed:23104059). Involved in peripheral melanosomal distribution of TYRP1 in melanocytes; the function, which probably is implicating vesicle-trafficking, includes cooperation with Rab32, Rab38 and VAMP7 (By similarity). Involved in the regulation of neurite growth; the function seems to require its GEF activity, probably towards Rab21, and VAMP7 but not Rab32/38 (By similarity). Proposed to be involved in Golgi sorting of VAMP7 and transport of VAMP7 vesicles to the cell surface; the function seems to implicate kinesin heavy chain isoform 5 proteins, GOLGA4, RAB21 and MACF1 (PubMed:22705394). Required for the colocalization of VAMP7 and Rab21, probably on TGN sites (PubMed:19745841). Involved in GLUT1 endosome-to-plasma membrane trafficking; the function is dependent of association with VPS29 (PubMed:24856514). Regulates the proper trafficking of melanogenic enzymes TYR, TYRP1 and DCT/TYRP2 to melanosomes in melanocytes (By similarity). {ECO:0000250\|UniProtKB:Q3UMR0, ECO:0000269\|PubMed:23104059, ECO:0000269\|PubMed:24856514, ECO:0000305\|PubMed:16525121, ECO:0000305\|PubMed:18477474, ECO:0000305\|PubMed:22705394}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

SENP2

chr3:185304302

chr19:33133051

ENST00000296257

28_31

590.0

Motif

Nuclear localization signal

Tgene

ANKRD27

chr3:185304302

chr19:33133051

ENST00000306065

396_426

260

1051.0

Repeat

Note=ANK 1

Tgene

ANKRD27

chr3:185304302

chr19:33133051

ENST00000306065

462_491

260

1051.0

Repeat

Note=ANK 2

Tgene

ANKRD27

chr3:185304302

chr19:33133051

ENST00000306065

495_524

260

1051.0

Repeat

Note=ANK 3

Tgene

ANKRD27

chr3:185304302

chr19:33133051

ENST00000306065

528_560

260

1051.0

Repeat

Note=ANK 4

Tgene

ANKRD27

chr3:185304302

chr19:33133051

ENST00000306065

564_593

260

1051.0

Repeat

Note=ANK 5

Tgene

ANKRD27

chr3:185304302

chr19:33133051

ENST00000306065

597_627

260

1051.0

Repeat

Note=ANK 6

Tgene

ANKRD27

chr3:185304302

chr19:33133051

ENST00000306065

668_698

260

1051.0

Repeat

Note=ANK 7

Tgene

ANKRD27

chr3:185304302

chr19:33133051

ENST00000306065

743_772

260

1051.0

Repeat

Note=ANK 8

Tgene

ANKRD27

chr3:185304302

chr19:33133051

ENST00000306065

776_805

260

1051.0

Repeat

Note=ANK 9

Tgene

ANKRD27

chr3:185304302

chr19:33133051

ENST00000306065

809_838

260

1051.0

Repeat

Note=ANK 10

Tgene

ANKRD27

chr3:185304302

chr19:33133051

ENST00000306065

842_871

260

1051.0

Repeat

Note=ANK 11

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

SENP2

chr3:185304302

chr19:33133051

ENST00000296257

317_332

590.0

Motif

Note=Nuclear export signal

Hgene

SENP2

chr3:185304302

chr19:33133051

ENST00000296257

46_51

590.0

Motif

Nuclear localization signal

Hgene

SENP2

chr3:185304302

chr19:33133051

ENST00000296257

396_560

590.0

Region

Note=Protease

Tgene

ANKRD27

chr3:185304302

chr19:33133051

ENST00000306065

233_371

260

1051.0

Domain

VPS9

Tgene

ANKRD27

chr3:185304302

chr19:33133051

ENST00000306065

1_372

260

1051.0

Region

Sufficient for GEF activity towards RAB21

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Fusion Gene Sequence for SENP2-ANKRD27

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>80372_80372_1_SENP2-ANKRD27_SENP2_chr3_185304302_ENST00000296257_ANKRD27_chr19_33133051_ENST00000306065_length(transcript)=3850nt_BP=341nt
GTGCGCAGATTGAGAATGGAGCTTTCCGGTCGGGCGGGAGGAGGTGACGTCAGGAGTGGTGGCGGGCGGGGGCCTCTGGTAGCCCTGGGG
ACGCTGTATCTGTGGGCTCTTGAATCGCGTCACAAATCAGCGACCGAACTCTGGCGGTGGTGGTTAAGACGGCGAAGGCGGCAGCGGCGG
CGACAGCTCTGGGGTTTGCGTCTCGGGGTGTGTCGGCCGCCGCTGCTGCTTGGGCCTGGTATGTACAGATGGCTGGTTAGGATTCTCGGC
ACCATTTTCCGTTTCTGCGACCGGTCGGTGCCCCCTGCCCGGGCCCTCCTGAAGAGGCGGCGCTCAGACAGCTTTAACATACCTCGTGCC
AAAAGAGAGCTGGCTCAGCTGAACAAATGCACCTCCCCACAGCAGAAGCTTGTCTGCTTGCGAAAAGTGGTGCAGCTCATTACACAGTCT
CCAAGCCAGAGAGTGAACCTGGAGACCATGTGTGCTGATGATCTGCTATCAGTCCTGTTATACTTGCTTGTGAAAACGGAGATCCCTAAT
TGGATGGCAAATTTGAGTTACATCAAAAACTTCAGGTTTAGCAGCTTGGCAAAGGATGAACTGGGATACTGCCTGACCTCATTCGAAGCT
GCCATTGAATATATTCGGCAAGGAAGCCTCTCTGCTAAACCCCCTGAGTCTGAGGGATTTGGAGACAGGCTGTTCCTTAAGCAGAGAATG
AGCTTACTCTCTCAGATGACTTCGTCTCCCACCGACTGCCTGTTTAAGCACATTGCATCAGGTAACCAGAAAGAAGTGGAGAGACTTCTG
AGCCAAGAGGACCATGATAAAGATACCGTCCAAAAGATGTGTCACCCTCTCTGCTTCTGCGATGACTGTGAGAAACTCGTCTCTGGGAGG
TTGAATGATCCCTCAGTTGTCACTCCATTCTCCAGAGACGACAGGGGGCACACCCCTCTCCATGTGGCTGCTGTCTGTGGGCAGGCATCC
CTCATCGACCTCCTGGTTTCCAAGGGCGCCATGGTAAATGCCACAGACTACCATGGAGCCACTCCGCTCCACCTGGCCTGTCAGAAGGGC
TACCAGAGCGTGACGCTGCTGCTGCTGCACTACAAGGCCAGCGCGGAAGTGCAGGACAACAATGGGAATACGCCACTCCACCTGGCCTGC
ACCTACGGCCACGAGGACTGTGTGAAGGCTCTGGTTTACTACGACGTGGAGTCGTGCAGACTTGACATTGGCAATGAGAAAGGAGACACC
CCTCTACACATTGCTGCCCGCTGGGGCTACCAAGGCGTCATAGAGACATTGCTGCAGAACGGAGCGTCCACCGAGATCCAGAACAGACTG
AAGGAGACGCCCCTCAAGTGTGCATTAAACTCAAAGATTCTGTCTGTAATGGAAGCCTATCACCTGTCCTTCGAGAGGAGGCAGAAGTCG
TCCGAGGCCCCTGTGCAGTCCCCGCAGCGCTCCGTGGACTCCATCAGCCAAGAGTCCTCCACTTCCAGCTTCTCCTCCATGTCAGCCAGC
TCAAGGCAGGAGGAGACCAAGAAGGACTACAGAGAGGTAGAAAAACTTTTGAGAGCAGTTGCTGATGGAGATCTAGAAATGGTGCGTTAC
CTGTTGGAATGGACAGAGGAGGACCTGGAGGATGCGGAGGACACTGTCAGTGCAGCGGACCCCGAATTCTGTCACCCGTTGTGCCAGTGC
CCCAAGTGTGCCCCAGCTCAGAAGAGGCTGGCGAAGGTTCCTGCCAGTGGGCTTGGTGTGAACGTGACCAGCCAGGACGGCTCCTCCCCG
CTGCATGTCGCCGCCCTGCACGGCCGGGCGGACCTCATCCCCCTCCTGCTGAAGCACGGGGCCAACGCAGGTGCCAGGAACGCAGACCAA
GCCGTCCCGCTCCACCTGGCCTGCCAGCAGGGCCACTTTCAGGTGGTGAAGTGTCTGTTAGATTCGAATGCAAAACCCAATAAGAAGGAC
CTCAGTGGAAACACGCCCCTCATTTACGCCTGCTCCGGTGGCCATCACGAGCTTGTGGCACTGCTGCTACAGCACGGGGCCTCCATTAAC
GCTTCTAACAATAAGGGCAACACAGCGCTGCACGAGGCTGTGATTGAAAAGCACGTCTTCGTGGTAGAGCTGCTTCTGCTCCACGGAGCG
TCAGTTCAGGTGCTGAACAAGCGGCAGCGCACGGCTGTAGACTGTGCTGAACAGAATTCAAAAATAATGGAATTGCTTCAGGTGGTACCA
AGCTGTGTTGCTTCATTAGATGATGTGGCTGAAACTGACCGCAAGGAGTATGTCACTGTTAAGATCAGGAAAAAATGGAACTCAAAACTG
TATGATCTACCAGATGAGCCTTTTACAAGACAGTTTTACTTTGTCCACTCAGCTGGTCAGTTTAAGGGAAAGACTTCAAGGGAGATTATG
GCAAGAGATAGAAGTGTCCCTAATTTAACCGAAGGTTCTTTGCATGAGCCAGGGAGGCAAAGTGTCACACTGAGACAGAATAACCTGCCA
GCTCAGAGTGGATCTCATGCTGCTGAGAAAGGCAACAGCGACTGGCCAGAGAGGCCTGGACTGACACAGACTGGCCCTGGACACAGACGG
ATGCTGCGGAGACACACGGTAGAGGATGCGGTCGTGTCCCAGGGCCCGGAGGCTGCTGGCCCCCTCTCCACTCCCCAAGAGGTTAGTGCT
TCCCGGTCCTAACAGGAATGAGGAGTTGTTGAACCCACTGCTAGGAAGCAAGGATGCAACAAGATGATGCTGAGCGTGAACACATCTGAG
AACTAAATGTGCTTCCATGAGACTGGCTTGAGAAGTCTTCAGCACCAAGTTCCTGAAAGCTTTTCTGTGGCAGGAAAGAATGCAACAAAA
AAGTTAACCACCACCATCTCTCTCCTCTTCAAAGCTAATGAATACAATTGAAACAGACAAAAATTCCAGTAGCATCCAGATCCTTAAGCC
AGAGGTGCATGCTTCTTTTTAAGTATGAGGGTTTGTTGGTCACAGTGGGAGAGGTTTCACCACCGCATTCTGACCTCCTCCTCCCAAAAG
GTGCTAAACCTCTCTGACCTGTGTACATTCACAAACCACAGCTAGAATTCCTCCACCTAGGATTAAGCTGGAGAGAAGTAAGTAATTTAG
GTTTCATGGTACTGTAGAGGCCAGGCTGAAATGTCATATCTGAAGGAAGAAAGCAGCAGCTGGACAATGTTTCTTTGCAAAGCAACACTC
GAACCAAAAGATGCCTCAATCCCATTTTGATATTCATTTTAGTGAAAGGATGCATCAGACCTGTTCCACATCATGCACATGGGAAAGGGT
GGTTATCATTTTCCTTCTAACAAGTAGGTACAGATATTCGGTTACTACACGTGCACCTGTAGCAGTATTTCTAGAAACATCCCTTTTTGT
TGAGAACCTCCCTTGAATGTCTGTCACACTCACACCTGACGGGATGGTTACTGGATTAGAGAGTAGATTTGGCACATCTTTTCTTAGTCT
TTTGATTCAAATTCAAAACTTAACAGCACAAACCAGGTCAGAGTTACTTTCGGTTAGAATTTATTGCCATTTATTCCTTTTTATAAATTT
CTATAGATTATACTGTTATTTTTATGTTATTGGCCTAGAGCTACACGTATATGGGTTTGTCCTGAGTCCGTTTTCAAATGACCTTGTGAT
AGGGAAATGGTTTTGTCCATGTTCTTGGAAATACTTGTGTATGTACAGAAGGAAGGGAGGGATTATTTTTCTACAAAGTAATTTATGATT

>80372_80372_1_SENP2-ANKRD27_SENP2_chr3_185304302_ENST00000296257_ANKRD27_chr19_33133051_ENST00000306065_length(amino acids)=900AA_BP=110
MRMELSGRAGGGDVRSGGGRGPLVALGTLYLWALESRHKSATELWRWWLRRRRRQRRRQLWGLRLGVCRPPLLLGPGMYRWLVRILGTIF
RFCDRSVPPARALLKRRRSDSFNIPRAKRELAQLNKCTSPQQKLVCLRKVVQLITQSPSQRVNLETMCADDLLSVLLYLLVKTEIPNWMA
NLSYIKNFRFSSLAKDELGYCLTSFEAAIEYIRQGSLSAKPPESEGFGDRLFLKQRMSLLSQMTSSPTDCLFKHIASGNQKEVERLLSQE
DHDKDTVQKMCHPLCFCDDCEKLVSGRLNDPSVVTPFSRDDRGHTPLHVAAVCGQASLIDLLVSKGAMVNATDYHGATPLHLACQKGYQS
VTLLLLHYKASAEVQDNNGNTPLHLACTYGHEDCVKALVYYDVESCRLDIGNEKGDTPLHIAARWGYQGVIETLLQNGASTEIQNRLKET
PLKCALNSKILSVMEAYHLSFERRQKSSEAPVQSPQRSVDSISQESSTSSFSSMSASSRQEETKKDYREVEKLLRAVADGDLEMVRYLLE
WTEEDLEDAEDTVSAADPEFCHPLCQCPKCAPAQKRLAKVPASGLGVNVTSQDGSSPLHVAALHGRADLIPLLLKHGANAGARNADQAVP
LHLACQQGHFQVVKCLLDSNAKPNKKDLSGNTPLIYACSGGHHELVALLLQHGASINASNNKGNTALHEAVIEKHVFVVELLLLHGASVQ
VLNKRQRTAVDCAEQNSKIMELLQVVPSCVASLDDVAETDRKEYVTVKIRKKWNSKLYDLPDEPFTRQFYFVHSAGQFKGKTSREIMARD
RSVPNLTEGSLHEPGRQSVTLRQNNLPAQSGSHAAEKGNSDWPERPGLTQTGPGHRRMLRRHTVEDAVVSQGPEAAGPLSTPQEVSASRS

--------------------------------------------------------------
>80372_80372_2_SENP2-ANKRD27_SENP2_chr3_185304302_ENST00000296257_ANKRD27_chr19_33133051_ENST00000587352_length(transcript)=2731nt_BP=341nt
GTGCGCAGATTGAGAATGGAGCTTTCCGGTCGGGCGGGAGGAGGTGACGTCAGGAGTGGTGGCGGGCGGGGGCCTCTGGTAGCCCTGGGG
ACGCTGTATCTGTGGGCTCTTGAATCGCGTCACAAATCAGCGACCGAACTCTGGCGGTGGTGGTTAAGACGGCGAAGGCGGCAGCGGCGG
CGACAGCTCTGGGGTTTGCGTCTCGGGGTGTGTCGGCCGCCGCTGCTGCTTGGGCCTGGTATGTACAGATGGCTGGTTAGGATTCTCGGC
ACCATTTTCCGTTTCTGCGACCGGTCGGTGCCCCCTGCCCGGGCCCTCCTGAAGAGGCGGCGCTCAGACAGCTTTAACATACCTCGTGCC
AAAAGAGAGCTGGCTCAGCTGAACAAATGCACCTCCCCACAGCAGAAGCTTGTCTGCTTGCGAAAAGTGGTGCAGCTCATTACACAGTCT
CCAAGCCAGAGAGTGAACCTGGAGACCATGTGTGCTGATGATCTGCTATCAGTCCTGTTATACTTGCTTGTGAAAACGGAGATCCCTAAT
TGGATGGCAAATTTGAGTTACATCAAAAACTTCAGGTTTAGCAGCTTGGCAAAGGATGAACTGGGATACTGCCTGACCTCATTCGAAGCT
GCCATTGAATATATTCGGCAAGGAAGCCTCTCTGCTAAACCCCCTGTAAGATCTCACCCCTGCCCTGGCCTTCCTTTGTGGGCATCATGG
TTCCCTTGATAGGGTGCTGGGGTTGGTATGTGGGCAGACGGATTCTTAAATTGCCTCCCAGGAATGGGGCCTCAGCTGTTTGAGGGCTGT
GAGTCTTAAAAATCACTCAGTGAAGAGAACACCAAGCCCTCAATTGGTGGTAAAAATTGGTGGGTTATCATTGGGATTTACATTGTTAAT
ATCCTACTTCATTAGTCCCCATCCTCTCCAAAGACATGTGGGTGCAAAGGGAAGCCAGAAGTAGGGAATTTGGATTTCTTGACCTTGATA
GTCAAGAAGTGATGTCACGGGATCCCTGGACTGTCGCTTTTCCAGCCGGAAACCTCTGTGGCTGGTGGCTCCTTTGCCTGAGTTTTGTTC
GGGCCTGCTGGGCTCATTTCACGCTCTTGGCCTGGCAGGCTGCGCTCGGCTTGTGCTACTGGCCTGGATCCCATGCCTGCCAAGGGCGAG
CCAGGTGTGGAGTGGCGAGGGGTATGTGAGCAAGTGCAGGGTCTGGCCACTGCACACAACCAGGTGTGCCGACTGAGGTGGGGTGGGCAG
CTCCAAGTTGCTTGTACAGGGTCCTGCTCCATGCAAGGCTGCAGCTAGAGCAGGCGTACTGTAGGCCGCTTCCACGGTGGGCACTGGGGA
ACACAGTGGGGCCTGGAAGCTTGGAGACACCAGGAACTGCAGAGCCCCAAAGAGGGTGTCATAGCCCTGGCTCGGGGAACTCCTAGGTTG
GGCTCCCTGAAGGGCCAGAGCTCTTCTCTCCTCTCGTCACCTGCAATGTAGTGAGTCGGGAGCATGTTTTAGCTCTCTTTATGTTACAGC
TCTTTCAGTCCTGCCATTTGGTGGGTCCCGAGTTCTTGTCCCATGTCGAGGAAGAATGAGGTACGTAGACTAGTGGAGGGTGAGCAAGGC
AGAGAGGAGCTTTACTGAACGGCAGAATAGCTCTCAGGAGACCCACAGTGGGCAGCTTCTTTCCACAGGCAGGTCGTCCTGACGAGTTAA
AGAGGCCTGACGTAGGTAGCTCCTTCCTGCAGTTGGTAGTCCCGACATCTGTCTGAGTCTGGCTGAGTCCGGGGTTTTTTATGGCTCAGA
AGGGAGGGAGTATGTGCTGATTGGTCCATAGGTGGGCCTGGAGAAAGCACCATGAGTTCTCAGTCTGGGTCGTGGACTCCACTTGGGACT
GACAGCCCGGCCCCCAGGCTTTAGGCTGTCCCTGTCTTGAAGGTGGGGCTTCACTGGGCACCTGCACCTTTCCACCCAGAAGCGTGTCTG
CCTTCTGCCACCATCAACATGCTGGCCAGTGCATCCAGGCTGTTTGTGCCAAGGGGCATCTGCAGGCCTGCACTGAGCTGCCCTCAGCCC
CTACCTTGACTACTCTCCCATGCTCATCAGCGCCCAAAATCTTGGAGGGGTCTGAGGCATCAGGAGGCTGGTGTGTCAGTGTCACACCAA
GCATGTGCACACATGGCTGGGTTGCAACAGTACCCGGGCTTGGCCTCAGCTTTGCTCTGAAATTGAAGTCGGTGCCAGGAGTGGGGAGGA
GCGGGAGCAGGCACTTACGAGCCTGCGGCGGCAGGGATGCTTCCTGGGCCCCTGAGAGTGCAGAGATTCCTGGATCCAGAGCTGCGGCTG
GGCGGCTGCAGCTGCGCCTGGGAGTGCAGGGCTCCCGCCCTGCCAGCTCAGTAGGAGATGGGGGCTCCTGCCTGTTCCTGGCTCCTGTTG
GCCCTGCAGAGTGCACAAACCTGGCCGCGCTTCCTCCACTGCAGCTTACGTCTTTGCAGCAGCCACTCCCGATGGGCTGCCACTGCCATC
TGTGAGACCATTAATGTGTGCAATTTGAGGACTCAGTGGCCTTGCCATTGTTTCCTTGGTTTTTATTGAGCATTGGCTGGGGTCGGCGAG
GGGATGTGATTATATTTCTATGTGAATCGTGAGAATCTTGAACCATGGTTGTCCTGCTGGCCTGTTTTACTACATACCAATGAGTAAAAT

>80372_80372_2_SENP2-ANKRD27_SENP2_chr3_185304302_ENST00000296257_ANKRD27_chr19_33133051_ENST00000587352_length(amino acids)=239AA_BP=110
MRMELSGRAGGGDVRSGGGRGPLVALGTLYLWALESRHKSATELWRWWLRRRRRQRRRQLWGLRLGVCRPPLLLGPGMYRWLVRILGTIF
RFCDRSVPPARALLKRRRSDSFNIPRAKRELAQLNKCTSPQQKLVCLRKVVQLITQSPSQRVNLETMCADDLLSVLLYLLVKTEIPNWMA

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Fusion Gene PPI Analysis for SENP2-ANKRD27

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Still interaction with
Tgene	ANKRD27	chr3:185304302	chr19:33133051	ENST00000306065		8	29	451_730	260.6666666666667	1051.0	RAB32
Tgene	ANKRD27	chr3:185304302	chr19:33133051	ENST00000306065		8	29	451_600	260.6666666666667	1051.0	RAB38

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for SENP2-ANKRD27

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for SENP2-ANKRD27

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source