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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:SENP2-LIPH (FusionGDB2 ID:80378)

Fusion Gene Summary for SENP2-LIPH

check button Fusion gene summary
Fusion gene informationFusion gene name: SENP2-LIPH
Fusion gene ID: 80378
HgeneTgene
Gene symbol

SENP2

LIPH

Gene ID

59343

200879

Gene nameSUMO specific peptidase 2lipase H
SynonymsAXAM2|SMT3IP2AH|ARWH2|HYPT7|LAH2|LPDLR|PLA1B|mPA-PLA1
Cytomap

3q27.2

3q27.2

Type of geneprotein-codingprotein-coding
Descriptionsentrin-specific protease 2SMT3-specific isopeptidase 2SUMO1/sentrin/SMT3 specific peptidase 2SUMO1/sentrin/SMT3 specific protease 2sentrin (SUMO1) specific peptidase 2sentrin/SUMO-specific protease SENP2lipase member HLPD lipase-related proteinlipase, member HmPA-PLA1 alphamembrane-associated phosphatidic acid-selective phospholipase A1-alphamembrane-bound phosphatidic acid-selective phospholipase A1phospholipase A(1)phospholipase A1 member B
Modification date2020031320200313
UniProtAcc.

Q8WWY8

Ensembl transtripts involved in fusion geneENST00000296257, ENST00000427465, 
ENST00000545472, ENST00000465201, 
ENST00000424591, ENST00000296252, 
Fusion gene scores* DoF score13 X 12 X 10=15607 X 7 X 5=245
# samples 167
** MAII scorelog2(16/1560*10)=-3.28540221886225
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(7/245*10)=-1.8073549220576
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SENP2 [Title/Abstract] AND LIPH [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointSENP2(185341870)-LIPH(185226665), # samples:1
Anticipated loss of major functional domain due to fusion event.SENP2-LIPH seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneSENP2

GO:0016926

protein desumoylation

20194620

HgeneSENP2

GO:0031397

negative regulation of protein ubiquitination

22028379

TgeneLIPH

GO:0016042

lipid catabolic process

12963729


check buttonFusion gene breakpoints across SENP2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across LIPH (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LGGTCGA-HT-A5RA-01ASENP2chr3

185341870

+LIPHchr3

185226665

-


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Fusion Gene ORF analysis for SENP2-LIPH

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000296257ENST00000424591SENP2chr3

185341870

+LIPHchr3

185226665

-
Frame-shiftENST00000427465ENST00000424591SENP2chr3

185341870

+LIPHchr3

185226665

-
Frame-shiftENST00000545472ENST00000424591SENP2chr3

185341870

+LIPHchr3

185226665

-
In-frameENST00000296257ENST00000296252SENP2chr3

185341870

+LIPHchr3

185226665

-
In-frameENST00000427465ENST00000296252SENP2chr3

185341870

+LIPHchr3

185226665

-
In-frameENST00000545472ENST00000296252SENP2chr3

185341870

+LIPHchr3

185226665

-
intron-3CDSENST00000465201ENST00000296252SENP2chr3

185341870

+LIPHchr3

185226665

-
intron-3CDSENST00000465201ENST00000424591SENP2chr3

185341870

+LIPHchr3

185226665

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000545472SENP2chr3185341870+ENST00000296252LIPHchr3185226665-42251609281629533
ENST00000296257SENP2chr3185341870+ENST00000296252LIPHchr3185226665-4467185191871620
ENST00000427465SENP2chr3185341870+ENST00000296252LIPHchr3185226665-427916634871683398

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000545472ENST00000296252SENP2chr3185341870+LIPHchr3185226665-0.001053120.99894685
ENST00000296257ENST00000296252SENP2chr3185341870+LIPHchr3185226665-0.0039273460.99607265
ENST00000427465ENST00000296252SENP2chr3185341870+LIPHchr3185226665-0.0007823350.9992176

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Fusion Genomic Features for SENP2-LIPH


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for SENP2-LIPH


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:185341870/chr3:185226665)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.LIPH

Q8WWY8

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Hydrolyzes specifically phosphatidic acid (PA) to produce 2-acyl lysophosphatidic acid (LPA; a potent bioactive lipid mediator) and fatty acid. Does not hydrolyze other phospholipids, like phosphatidylserine (PS), phosphatidylcholine (PC) and phosphatidylethanolamine (PE) or triacylglycerol (TG). {ECO:0000269|PubMed:12063250, ECO:0000269|PubMed:12963729}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSENP2chr3:185341870chr3:185226665ENST00000296257+151728_31537590.0MotifNuclear localization signal
HgeneSENP2chr3:185341870chr3:185226665ENST00000296257+1517317_332537590.0MotifNote=Nuclear export signal
HgeneSENP2chr3:185341870chr3:185226665ENST00000296257+151746_51537590.0MotifNuclear localization signal

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSENP2chr3:185341870chr3:185226665ENST00000296257+1517396_560537590.0RegionNote=Protease


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Fusion Gene Sequence for SENP2-LIPH


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>80378_80378_1_SENP2-LIPH_SENP2_chr3_185341870_ENST00000296257_LIPH_chr3_185226665_ENST00000296252_length(transcript)=4467nt_BP=1851nt
GTGCGCAGATTGAGAATGGAGCTTTCCGGTCGGGCGGGAGGAGGTGACGTCAGGAGTGGTGGCGGGCGGGGGCCTCTGGTAGCCCTGGGG
ACGCTGTATCTGTGGGCTCTTGAATCGCGTCACAAATCAGCGACCGAACTCTGGCGGTGGTGGTTAAGACGGCGAAGGCGGCAGCGGCGG
CGACAGCTCTGGGGTTTGCGTCTCGGGGTGTGTCGGCCGCCGCTGCTGCTTGGGCCTGGTATGTACAGATGGCTGGTTAGGATTCTCGGC
ACCATTTTCCGTTTCTGCGACCGGTCGGTGCCCCCTGCCCGGGCCCTCCTGAAGAGGCGGCGCTCAGACAGCACTCTGTTTTCTACAGTG
GACACTGATGAAATACCAGCCAAAAGACCAAGATTAGATTGCTTTATTCACCAAGTGAAAAACAGTCTCTACAATGCTGCCAGCTTATTT
GGATTCCCATTCCAGCTGACCACAAAGCCCATGGTAACTTCTGCTTGTAATGGAACACGGAATGTGGCCCCTTCAGGAGAGGTATTTTCG
AACTCTTCATCTTGTGAACTGACAGGTTCTGGATCCTGGAACAACATGCTGAAACTGGGTAATAAATCTCCTAATGGAATAAGTGACTAT
CCAAAGATCAGAGTGACAGTTACCCGAGATCAGCCACGCAGAGTCCTGCCTTCCTTTGGTTTTACTTTGAACTCAGAAGGCTGTAATAGA
AGACCAGGTGGCCGTCGCCATAGCAAAGGTAATCCAGAGAGTTCTTTAATGTGGAAACCTCAGGAACAGGCTGTAACAGAGATGATTTCT
GAAGAGAGTGGCAAGGGTCTGAGGCGTCCCCATTGTACTGTGGAGGAGGGTGTTCAAAAAGAGGAAAGAGAGAAGTACCGAAAGTTATTG
GAACGACTTAAAGAAAGTGGTCATGGAAACTCTGTCTGTCCTGTAACTTCAAATTATCACAGTTCTCAAAGAAGTCAGATGGACACATTA
AAGACCAAAGGCTGGGGGGAAGAGCAAAATCACGGAGTCAAAACAACTCAGTTTGTTCCAAAACAATATAGACTTGTTGAAACAAGGGGA
CCTCTATGTTCATTGAGAAGTGAAAAGAGGTGTTCAAAGGGGAAAATTACTGATACAGAGACGATGGTCGGAATCAGATTTGAAAATGAA
AGTAGGAGGGGATACCAACTGGAGCCTGACCTATCAGAAGAAGTGTCGGCCCGACTCCGCCTGGGCAGTGGAAGCAATGGCTTACTCAGG
AGGAAAGTGTCAATAATTGAGACAAAGGAAAAGAATTGCTCAGGCAAAGAGAGGGACAGAAGAACGGACGATCTCCTTGAACTTACAGAG
GACATGGAAAAGGAAATCAGTAATGCCCTAGGCCATGGCCCACAGGATGAAATCCTAAGTAGTGCTTTCAAATTGCGAATTACTCGAGGA
GATATTCAGACATTAAAGAACTATCACTGGCTCAATGATGAAGTCATTAATTTTTACATGAATCTTCTGGTGGAAAGAAATAAAAAGCAA
GGCTATCCAGCACTTCATGTATTCAGTACTTTCTTCTATCCTAAATTAAAGTCTGGGGGTTACCAAGCAGTGAAACGATGGACCAAAGGG
GTAAATCTCTTTGAACAAGAAATTATTCTGGTGCCTATTCATCGGAAGGTACATTGGAGCCTGGTGGTGATTGACCTAAGAAAAAAGTGT
CTTAAATATCTGGATTCTATGGGACAAAAGGGCCACAGGATCTGTGAGATTCTCCTTCAGTATTTACAGGATGAAAGTAAGACCAAAAGA
AATAGTGATCTGAATCTTTTAGAGTGGACCCATCACAGCATGAAACCACACGCCTCAGCTGTGTCGGTATGATCTTGTCCTGATGGAAAA
CGTTGAAACAGTCTTCCAACCTATTCTTTGCCCAGAGTTGCAGTTGTAACTGTTGCCAGGACACATGGCCATAAATAATAGAAAGAAAGC
TACAACCACAGGCTGTTTGAAAGCTTCACCTCACCTTTCTGCAAGGCAGAAAAAGTATGAAAAAAACCAAGGCTTTTTTCAGTAGCGTCC
TATGGATGTCACATTGTACATCAAACAACCTTGTGATTATAAAACGATCCTGGGAAGGAGCCCCTAACTAGGGCAAGTCAGAAATAGCCA
GGCTCGCAGCAGCGCAGCGCTGTGTCTGCTGTGTCCTGGGGCCTCCCTTGTTCCGACCTGTCAATTCTGCTGCCTGTCACGCGGGTGGTT
CTGCCCATCGCGGCTGCGGGTCAAGCATCTTCAAGGGAAGGACGGACTGGAGGCCTCACCGTGGACTCAACTCTGCATTCTCCGTGCCAC
ATTCCTCCAGTTCCCACACGTAGAAGGGAACGAAACTGACGTCTACCTCATGGGGCTGCTGTGTGGGTTTGGGAGGCAAAAATCTATGAA
GGGTTTTTTGAAATCCCATAGGTGCCACATCTATGAGATGTTTGATAAATGTGAATATGCTTTTACATTTGGGCTTATCTAATTTGCAAT
AAGAGAGCCTCTCTCTATCAACACCAGCTTCTCTCTCGGGCTGTTTGCTCAGGGAAGGCAAGAAAGCCACGTGCTGGCCCTCTGCCTTCT
CTAAAGTGCTGTTGGAGCATGGAGGAGCTGGAGGAGATGGGGATGGACTGACAGCTAAGAGGGCGGCTGCTGGGACTAGATAGTGGATGA
AGAAAGAAGGACGAGGAAGCCGTGGGGCAGCCTCTTCACATGGGGACAGGGGATGGAGCATGAGGCAAGGGAAGGAAAAGCAGAGCTTAT
TTTTCACCTAAGGTGGAGAAGGATCACTTTACAGGCAACGCTCATTTTAAGCAACCCTTAAGAAATGTTTATGTTTCTTTATTACCAATG
TAATCTATGATTATTGAAGGAAATTTAGAAAATGCGTAGATACAAAATTAAAAAAAAATACTGTCCACGATCCTATTAGAGGTAATTAAT
GTTAGCCTTTTGGAACAAGGCTGTCACCTATTTTGCCAACACGTGAATTCAAAACATGAACCGGTTTGCTTTTGGAGAATCTGAAGACTC
CAGTTTGAGGAATCCTTTGCTTCCCTGGAGGTAGATGCTGTCTGCAAATCTAGAATGACAGCAGGAGTCCAGTCAAGAGGTCCTGTCAGG
CCAAGGCCAGAAAGAAGGGAGGACAATCCCTGGGGCCAGATGCCCAGTGTGAGGGGAGGCATGATCTGTCCCATGGCTGTGGCCACTGCA
GGAAGGTCTGTGAAAAGGAGGTGACAGGCCCAGTCACCTCCTCTTCACCCAAGTGATTGCTCCTTCAACTGCTATCTGTGAAAATAGCCT
TTGTTATGAAGAAATTGACTCTCTCTCTCTTTTTTTTTTTTTGGAGTTGCCTAGGCTGGAGTGCAATGGTACGATCTCAGCTCACTGCAA
CCTCCACCTCCCAGGTTCAATTGATTCTCCTGCCTCAGCCTCCTGAGTAGCTGGGATTACAGGCATGTGCCACCACACCCGGCTAATTTT
TGTATTTTTATTAGAGACAGGGTTTCACCACGTTAGCCAGGCTCGTCTCGAACTCCTGTCCTCAGGTGACTACCCGTCTCGGCCTCCCAA
AGTGCTGGGATTACAGGCATGAGCCACCACACCCGGCCAAAAATGGATTCTCTATGTCATAAATTAAAGAAATCTATAAATGTATTCCTG
TGTGGCACATCTTCTTACAGATTTACATTTGCAGCAAATACAGAGTCTGTTTTATTTAAGTGAGGGATGACTGAACTCTGAGTGGAACAA
GCTCTTGGACATGTTACCATCCTTCCTCCTCCTTCTCACATTTCCTCAGCAATTGTGGATAGAGAGATCAGTGTGCTGTAGGCCCTGGTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTAGATGGAGTCTCCTTCTGTTACCCAGGCTGGAGTGCAGTGGCACGATCTTGGCTCACTGCAA
CCTCTGCCTCCCGGGTTCAAGCAATTCTCTGCCTCAGCCTCCCAAGTAGCTGGGATTACAGGCGCCCCCACCATGCCTGGCTAATTTTTG
TATTTTTAGTAGAGACCTGGTTTCACCATCTTGGCCTTGAACTCCTGACCTTGTGATCCACTGGCCTTGGCCTCTCAAAGTTCTGGGATT
ACAGGTGTGAGCCATCGTACCCGGCAGCCCTGGTTTCTTCTTAGTTTTATTGGTCTGTGTTTTGATCAGCACAGTCACTTTTTTGTTCTC
TTTCCTGGTAAGCAGGGAGTCAAAACAATAGCAAGAAAATGCCAGAAATAGAATTTCTACTACTTTGTAAACTCTAGGCTCGTGGGTCTC
CTAGCTCTCAGTACCTGGCTCACTGTAGGATGGGTAGATGGGTGAATGAATGGATAAAGAAAGGAAGTTTGTTCACCGGAGAGGAGATGA

>80378_80378_1_SENP2-LIPH_SENP2_chr3_185341870_ENST00000296257_LIPH_chr3_185226665_ENST00000296252_length(amino acids)=620AA_BP=
MRMELSGRAGGGDVRSGGGRGPLVALGTLYLWALESRHKSATELWRWWLRRRRRQRRRQLWGLRLGVCRPPLLLGPGMYRWLVRILGTIF
RFCDRSVPPARALLKRRRSDSTLFSTVDTDEIPAKRPRLDCFIHQVKNSLYNAASLFGFPFQLTTKPMVTSACNGTRNVAPSGEVFSNSS
SCELTGSGSWNNMLKLGNKSPNGISDYPKIRVTVTRDQPRRVLPSFGFTLNSEGCNRRPGGRRHSKGNPESSLMWKPQEQAVTEMISEES
GKGLRRPHCTVEEGVQKEEREKYRKLLERLKESGHGNSVCPVTSNYHSSQRSQMDTLKTKGWGEEQNHGVKTTQFVPKQYRLVETRGPLC
SLRSEKRCSKGKITDTETMVGIRFENESRRGYQLEPDLSEEVSARLRLGSGSNGLLRRKVSIIETKEKNCSGKERDRRTDDLLELTEDME
KEISNALGHGPQDEILSSAFKLRITRGDIQTLKNYHWLNDEVINFYMNLLVERNKKQGYPALHVFSTFFYPKLKSGGYQAVKRWTKGVNL

--------------------------------------------------------------
>80378_80378_2_SENP2-LIPH_SENP2_chr3_185341870_ENST00000427465_LIPH_chr3_185226665_ENST00000296252_length(transcript)=4279nt_BP=1663nt
ACAAATCAGCGACCGAACTCTGGCGGTGGTGGTTAAGACGGCGAAGGCGGCAGCGGCGGCGACAGCTCTGGGGTTTGCGTCTCGGGGTGT
GTCGGCCGCCGCTGCTGCTTGGGCCTGGTATGTACAGATGGCTGGTTAGGATTCTCGGCACCATTTTCCGTTTCTGCGACCGGTCGGTGC
CCCCTGCCCGGGCCCTCCTGAAGAGGCGGCGCTCAGACAGCACTCTGTTTTCTACAGTGGACACTGATGAAATACCAGCCAAAAGACCAA
GATTAGATTGCTTTATTCACCAAGTGAAAAACAGTCTCTACAATGCTGCCAGCTTATTTGGATTCCCATTCCAGCTGACCACAAAGCCCA
TGGTAACTTCTGCTTGTAATGGAACACGGAATGTGGCCCCTTCAGGAGAGGTAATAAATCTCCTAATGGAATAAGTGACTATCCAAAGAT
CAGAGTGACAGTTACCCGAGATCAGCCACGCAGAGTCCTGCCTTCCTTTGGTTTTACTTTGAACTCAGAAGGCTGTAATAGAAGACCAGG
TGGCCGTCGCCATAGCAAAGGTAATCCAGAGAGTTCTTTAATGTGGAAACCTCAGGAACAGGCTGTAACAGAGATGATTTCTGAAGAGAG
TGGCAAGGGTCTGAGGCGTCCCCATTGTACTGTGGAGGAGGGTGTTCAAAAAGAGGAAAGAGAGAAGTACCGAAAGTTATTGGAACGACT
TAAAGAAAGTGGTCATGGAAACTCTGTCTGTCCTGTAACTTCAAATTATCACAGTTCTCAAAGAAGTCAGATGGACACATTAAAGACCAA
AGGCTGGGGGGAAGAGCAAAATCACGGAGTCAAAACAACTCAGTTTGTTCCAAAACAATATAGACTTGTTGAAACAAGGGGACCTCTATG
TTCATTGAGAAGTGAAAAGAGGTGTTCAAAGGGGAAAATTACTGATACAGAGACGATGGTCGGAATCAGATTTGAAAATGAAAGTAGGAG
GGGATACCAACTGGAGCCTGACCTATCAGAAGAAGTGTCGGCCCGACTCCGCCTGGGCAGTGGAAGCAATGGCTTACTCAGGAGGAAAGT
GTCAATAATTGAGACAAAGGAAAAGAATTGCTCAGGCAAAGAGAGGGACAGAAGAACGGACGATCTCCTTGAACTTACAGAGGACATGGA
AAAGGAAATCAGTAATGCCCTAGGCCATGGCCCACAGGATGAAATCCTAAGTAGTGCTTTCAAATTGCGAATTACTCGAGGAGATATTCA
GACATTAAAGAACTATCACTGGCTCAATGATGAAGTCATTAATTTTTACATGAATCTTCTGGTGGAAAGAAATAAAAAGCAAGGCTATCC
AGCACTTCATGTATTCAGTACTTTCTTCTATCCTAAATTAAAGTCTGGGGGTTACCAAGCAGTGAAACGATGGACCAAAGGGGTAAATCT
CTTTGAACAAGAAATTATTCTGGTGCCTATTCATCGGAAGGTACATTGGAGCCTGGTGGTGATTGACCTAAGAAAAAAGTGTCTTAAATA
TCTGGATTCTATGGGACAAAAGGGCCACAGGATCTGTGAGATTCTCCTTCAGTATTTACAGGATGAAAGTAAGACCAAAAGAAATAGTGA
TCTGAATCTTTTAGAGTGGACCCATCACAGCATGAAACCACACGCCTCAGCTGTGTCGGTATGATCTTGTCCTGATGGAAAACGTTGAAA
CAGTCTTCCAACCTATTCTTTGCCCAGAGTTGCAGTTGTAACTGTTGCCAGGACACATGGCCATAAATAATAGAAAGAAAGCTACAACCA
CAGGCTGTTTGAAAGCTTCACCTCACCTTTCTGCAAGGCAGAAAAAGTATGAAAAAAACCAAGGCTTTTTTCAGTAGCGTCCTATGGATG
TCACATTGTACATCAAACAACCTTGTGATTATAAAACGATCCTGGGAAGGAGCCCCTAACTAGGGCAAGTCAGAAATAGCCAGGCTCGCA
GCAGCGCAGCGCTGTGTCTGCTGTGTCCTGGGGCCTCCCTTGTTCCGACCTGTCAATTCTGCTGCCTGTCACGCGGGTGGTTCTGCCCAT
CGCGGCTGCGGGTCAAGCATCTTCAAGGGAAGGACGGACTGGAGGCCTCACCGTGGACTCAACTCTGCATTCTCCGTGCCACATTCCTCC
AGTTCCCACACGTAGAAGGGAACGAAACTGACGTCTACCTCATGGGGCTGCTGTGTGGGTTTGGGAGGCAAAAATCTATGAAGGGTTTTT
TGAAATCCCATAGGTGCCACATCTATGAGATGTTTGATAAATGTGAATATGCTTTTACATTTGGGCTTATCTAATTTGCAATAAGAGAGC
CTCTCTCTATCAACACCAGCTTCTCTCTCGGGCTGTTTGCTCAGGGAAGGCAAGAAAGCCACGTGCTGGCCCTCTGCCTTCTCTAAAGTG
CTGTTGGAGCATGGAGGAGCTGGAGGAGATGGGGATGGACTGACAGCTAAGAGGGCGGCTGCTGGGACTAGATAGTGGATGAAGAAAGAA
GGACGAGGAAGCCGTGGGGCAGCCTCTTCACATGGGGACAGGGGATGGAGCATGAGGCAAGGGAAGGAAAAGCAGAGCTTATTTTTCACC
TAAGGTGGAGAAGGATCACTTTACAGGCAACGCTCATTTTAAGCAACCCTTAAGAAATGTTTATGTTTCTTTATTACCAATGTAATCTAT
GATTATTGAAGGAAATTTAGAAAATGCGTAGATACAAAATTAAAAAAAAATACTGTCCACGATCCTATTAGAGGTAATTAATGTTAGCCT
TTTGGAACAAGGCTGTCACCTATTTTGCCAACACGTGAATTCAAAACATGAACCGGTTTGCTTTTGGAGAATCTGAAGACTCCAGTTTGA
GGAATCCTTTGCTTCCCTGGAGGTAGATGCTGTCTGCAAATCTAGAATGACAGCAGGAGTCCAGTCAAGAGGTCCTGTCAGGCCAAGGCC
AGAAAGAAGGGAGGACAATCCCTGGGGCCAGATGCCCAGTGTGAGGGGAGGCATGATCTGTCCCATGGCTGTGGCCACTGCAGGAAGGTC
TGTGAAAAGGAGGTGACAGGCCCAGTCACCTCCTCTTCACCCAAGTGATTGCTCCTTCAACTGCTATCTGTGAAAATAGCCTTTGTTATG
AAGAAATTGACTCTCTCTCTCTTTTTTTTTTTTTGGAGTTGCCTAGGCTGGAGTGCAATGGTACGATCTCAGCTCACTGCAACCTCCACC
TCCCAGGTTCAATTGATTCTCCTGCCTCAGCCTCCTGAGTAGCTGGGATTACAGGCATGTGCCACCACACCCGGCTAATTTTTGTATTTT
TATTAGAGACAGGGTTTCACCACGTTAGCCAGGCTCGTCTCGAACTCCTGTCCTCAGGTGACTACCCGTCTCGGCCTCCCAAAGTGCTGG
GATTACAGGCATGAGCCACCACACCCGGCCAAAAATGGATTCTCTATGTCATAAATTAAAGAAATCTATAAATGTATTCCTGTGTGGCAC
ATCTTCTTACAGATTTACATTTGCAGCAAATACAGAGTCTGTTTTATTTAAGTGAGGGATGACTGAACTCTGAGTGGAACAAGCTCTTGG
ACATGTTACCATCCTTCCTCCTCCTTCTCACATTTCCTCAGCAATTGTGGATAGAGAGATCAGTGTGCTGTAGGCCCTGGTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTAGATGGAGTCTCCTTCTGTTACCCAGGCTGGAGTGCAGTGGCACGATCTTGGCTCACTGCAACCTCTGCC
TCCCGGGTTCAAGCAATTCTCTGCCTCAGCCTCCCAAGTAGCTGGGATTACAGGCGCCCCCACCATGCCTGGCTAATTTTTGTATTTTTA
GTAGAGACCTGGTTTCACCATCTTGGCCTTGAACTCCTGACCTTGTGATCCACTGGCCTTGGCCTCTCAAAGTTCTGGGATTACAGGTGT
GAGCCATCGTACCCGGCAGCCCTGGTTTCTTCTTAGTTTTATTGGTCTGTGTTTTGATCAGCACAGTCACTTTTTTGTTCTCTTTCCTGG
TAAGCAGGGAGTCAAAACAATAGCAAGAAAATGCCAGAAATAGAATTTCTACTACTTTGTAAACTCTAGGCTCGTGGGTCTCCTAGCTCT
CAGTACCTGGCTCACTGTAGGATGGGTAGATGGGTGAATGAATGGATAAAGAAAGGAAGTTTGTTCACCGGAGAGGAGATGAATTTCAGT

>80378_80378_2_SENP2-LIPH_SENP2_chr3_185341870_ENST00000427465_LIPH_chr3_185226665_ENST00000296252_length(amino acids)=398AA_BP=
MPSFGFTLNSEGCNRRPGGRRHSKGNPESSLMWKPQEQAVTEMISEESGKGLRRPHCTVEEGVQKEEREKYRKLLERLKESGHGNSVCPV
TSNYHSSQRSQMDTLKTKGWGEEQNHGVKTTQFVPKQYRLVETRGPLCSLRSEKRCSKGKITDTETMVGIRFENESRRGYQLEPDLSEEV
SARLRLGSGSNGLLRRKVSIIETKEKNCSGKERDRRTDDLLELTEDMEKEISNALGHGPQDEILSSAFKLRITRGDIQTLKNYHWLNDEV
INFYMNLLVERNKKQGYPALHVFSTFFYPKLKSGGYQAVKRWTKGVNLFEQEIILVPIHRKVHWSLVVIDLRKKCLKYLDSMGQKGHRIC

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>80378_80378_3_SENP2-LIPH_SENP2_chr3_185341870_ENST00000545472_LIPH_chr3_185226665_ENST00000296252_length(transcript)=4225nt_BP=1609nt
AAGGATAATCCCACTCCTTGGCCAGTGGATGGACAGTCACCCATGTCTCTACTGTGGACCACAGGACAGCGAAGGCACCAACTGGCAGAC
AAGTCCCAGCACTCTGTTTTCTACAGTGGACACTGATGAAATACCAGCCAAAAGACCAAGATTAGATTGCTTTATTCACCAAGTGAAAAA
CAGTCTCTACAATGCTGCCAGCTTATTTGGATTCCCATTCCAGCTGACCACAAAGCCCATGGTAACTTCTGCTTGTAATGGAACACGGAA
TGTGGCCCCTTCAGGAGAGGTATTTTCGAACTCTTCATCTTGTGAACTGACAGGTTCTGGATCCTGGAACAACATGCTGAAACTGGGTAA
TAAATCTCCTAATGGAATAAGTGACTATCCAAAGATCAGAGTGACAGTTACCCGAGATCAGCCACGCAGAGTCCTGCCTTCCTTTGGTTT
TACTTTGAACTCAGAAGGCTGTAATAGAAGACCAGGTGGCCGTCGCCATAGCAAAGGTAATCCAGAGAGTTCTTTAATGTGGAAACCTCA
GGAACAGGCTGTAACAGAGATGATTTCTGAAGAGAGTGGCAAGGGTCTGAGGCGTCCCCATTGTACTGTGGAGGAGGGTGTTCAAAAAGA
GGAAAGAGAGAAGTACCGAAAGTTATTGGAACGACTTAAAGAAAGTGGTCATGGAAACTCTGTCTGTCCTGTAACTTCAAATTATCACAG
TTCTCAAAGAAGTCAGATGGACACATTAAAGACCAAAGGCTGGGGGGAAGAGCAAAATCACGGAGTCAAAACAACTCAGTTTGTTCCAAA
ACAATATAGACTTGTTGAAACAAGGGGACCTCTATGTTCATTGAGAAGTGAAAAGAGGTGTTCAAAGGGGAAAATTACTGATACAGAGAC
GATGGTCGGAATCAGATTTGAAAATGAAAGTAGGAGGGGATACCAACTGGAGCCTGACCTATCAGAAGAAGTGTCGGCCCGACTCCGCCT
GGGCAGTGGAAGCAATGGCTTACTCAGGAGGAAAGTGTCAATAATTGAGACAAAGGAAAAGAATTGCTCAGGCAAAGAGAGGGACAGAAG
AACGGACGATCTCCTTGAACTTACAGAGGACATGGAAAAGGAAATCAGTAATGCCCTAGGCCATGGCCCACAGGATGAAATCCTAAGTAG
TGCTTTCAAATTGCGAATTACTCGAGGAGATATTCAGACATTAAAGAACTATCACTGGCTCAATGATGAAGTCATTAATTTTTACATGAA
TCTTCTGGTGGAAAGAAATAAAAAGCAAGGCTATCCAGCACTTCATGTATTCAGTACTTTCTTCTATCCTAAATTAAAGTCTGGGGGTTA
CCAAGCAGTGAAACGATGGACCAAAGGGGTAAATCTCTTTGAACAAGAAATTATTCTGGTGCCTATTCATCGGAAGGTACATTGGAGCCT
GGTGGTGATTGACCTAAGAAAAAAGTGTCTTAAATATCTGGATTCTATGGGACAAAAGGGCCACAGGATCTGTGAGATTCTCCTTCAGTA
TTTACAGGATGAAAGTAAGACCAAAAGAAATAGTGATCTGAATCTTTTAGAGTGGACCCATCACAGCATGAAACCACACGCCTCAGCTGT
GTCGGTATGATCTTGTCCTGATGGAAAACGTTGAAACAGTCTTCCAACCTATTCTTTGCCCAGAGTTGCAGTTGTAACTGTTGCCAGGAC
ACATGGCCATAAATAATAGAAAGAAAGCTACAACCACAGGCTGTTTGAAAGCTTCACCTCACCTTTCTGCAAGGCAGAAAAAGTATGAAA
AAAACCAAGGCTTTTTTCAGTAGCGTCCTATGGATGTCACATTGTACATCAAACAACCTTGTGATTATAAAACGATCCTGGGAAGGAGCC
CCTAACTAGGGCAAGTCAGAAATAGCCAGGCTCGCAGCAGCGCAGCGCTGTGTCTGCTGTGTCCTGGGGCCTCCCTTGTTCCGACCTGTC
AATTCTGCTGCCTGTCACGCGGGTGGTTCTGCCCATCGCGGCTGCGGGTCAAGCATCTTCAAGGGAAGGACGGACTGGAGGCCTCACCGT
GGACTCAACTCTGCATTCTCCGTGCCACATTCCTCCAGTTCCCACACGTAGAAGGGAACGAAACTGACGTCTACCTCATGGGGCTGCTGT
GTGGGTTTGGGAGGCAAAAATCTATGAAGGGTTTTTTGAAATCCCATAGGTGCCACATCTATGAGATGTTTGATAAATGTGAATATGCTT
TTACATTTGGGCTTATCTAATTTGCAATAAGAGAGCCTCTCTCTATCAACACCAGCTTCTCTCTCGGGCTGTTTGCTCAGGGAAGGCAAG
AAAGCCACGTGCTGGCCCTCTGCCTTCTCTAAAGTGCTGTTGGAGCATGGAGGAGCTGGAGGAGATGGGGATGGACTGACAGCTAAGAGG
GCGGCTGCTGGGACTAGATAGTGGATGAAGAAAGAAGGACGAGGAAGCCGTGGGGCAGCCTCTTCACATGGGGACAGGGGATGGAGCATG
AGGCAAGGGAAGGAAAAGCAGAGCTTATTTTTCACCTAAGGTGGAGAAGGATCACTTTACAGGCAACGCTCATTTTAAGCAACCCTTAAG
AAATGTTTATGTTTCTTTATTACCAATGTAATCTATGATTATTGAAGGAAATTTAGAAAATGCGTAGATACAAAATTAAAAAAAAATACT
GTCCACGATCCTATTAGAGGTAATTAATGTTAGCCTTTTGGAACAAGGCTGTCACCTATTTTGCCAACACGTGAATTCAAAACATGAACC
GGTTTGCTTTTGGAGAATCTGAAGACTCCAGTTTGAGGAATCCTTTGCTTCCCTGGAGGTAGATGCTGTCTGCAAATCTAGAATGACAGC
AGGAGTCCAGTCAAGAGGTCCTGTCAGGCCAAGGCCAGAAAGAAGGGAGGACAATCCCTGGGGCCAGATGCCCAGTGTGAGGGGAGGCAT
GATCTGTCCCATGGCTGTGGCCACTGCAGGAAGGTCTGTGAAAAGGAGGTGACAGGCCCAGTCACCTCCTCTTCACCCAAGTGATTGCTC
CTTCAACTGCTATCTGTGAAAATAGCCTTTGTTATGAAGAAATTGACTCTCTCTCTCTTTTTTTTTTTTTGGAGTTGCCTAGGCTGGAGT
GCAATGGTACGATCTCAGCTCACTGCAACCTCCACCTCCCAGGTTCAATTGATTCTCCTGCCTCAGCCTCCTGAGTAGCTGGGATTACAG
GCATGTGCCACCACACCCGGCTAATTTTTGTATTTTTATTAGAGACAGGGTTTCACCACGTTAGCCAGGCTCGTCTCGAACTCCTGTCCT
CAGGTGACTACCCGTCTCGGCCTCCCAAAGTGCTGGGATTACAGGCATGAGCCACCACACCCGGCCAAAAATGGATTCTCTATGTCATAA
ATTAAAGAAATCTATAAATGTATTCCTGTGTGGCACATCTTCTTACAGATTTACATTTGCAGCAAATACAGAGTCTGTTTTATTTAAGTG
AGGGATGACTGAACTCTGAGTGGAACAAGCTCTTGGACATGTTACCATCCTTCCTCCTCCTTCTCACATTTCCTCAGCAATTGTGGATAG
AGAGATCAGTGTGCTGTAGGCCCTGGTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTAGATGGAGTCTCCTTCTGTTACCCAGGCTGGAGT
GCAGTGGCACGATCTTGGCTCACTGCAACCTCTGCCTCCCGGGTTCAAGCAATTCTCTGCCTCAGCCTCCCAAGTAGCTGGGATTACAGG
CGCCCCCACCATGCCTGGCTAATTTTTGTATTTTTAGTAGAGACCTGGTTTCACCATCTTGGCCTTGAACTCCTGACCTTGTGATCCACT
GGCCTTGGCCTCTCAAAGTTCTGGGATTACAGGTGTGAGCCATCGTACCCGGCAGCCCTGGTTTCTTCTTAGTTTTATTGGTCTGTGTTT
TGATCAGCACAGTCACTTTTTTGTTCTCTTTCCTGGTAAGCAGGGAGTCAAAACAATAGCAAGAAAATGCCAGAAATAGAATTTCTACTA
CTTTGTAAACTCTAGGCTCGTGGGTCTCCTAGCTCTCAGTACCTGGCTCACTGTAGGATGGGTAGATGGGTGAATGAATGGATAAAGAAA

>80378_80378_3_SENP2-LIPH_SENP2_chr3_185341870_ENST00000545472_LIPH_chr3_185226665_ENST00000296252_length(amino acids)=533AA_BP=
MDSHPCLYCGPQDSEGTNWQTSPSTLFSTVDTDEIPAKRPRLDCFIHQVKNSLYNAASLFGFPFQLTTKPMVTSACNGTRNVAPSGEVFS
NSSSCELTGSGSWNNMLKLGNKSPNGISDYPKIRVTVTRDQPRRVLPSFGFTLNSEGCNRRPGGRRHSKGNPESSLMWKPQEQAVTEMIS
EESGKGLRRPHCTVEEGVQKEEREKYRKLLERLKESGHGNSVCPVTSNYHSSQRSQMDTLKTKGWGEEQNHGVKTTQFVPKQYRLVETRG
PLCSLRSEKRCSKGKITDTETMVGIRFENESRRGYQLEPDLSEEVSARLRLGSGSNGLLRRKVSIIETKEKNCSGKERDRRTDDLLELTE
DMEKEISNALGHGPQDEILSSAFKLRITRGDIQTLKNYHWLNDEVINFYMNLLVERNKKQGYPALHVFSTFFYPKLKSGGYQAVKRWTKG

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Fusion Gene PPI Analysis for SENP2-LIPH


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for SENP2-LIPH


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for SENP2-LIPH


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource